Bibliografias temáticas / Tertiary lymphoid structure (TLS)

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Literatura científica selecionada sobre o tema "Tertiary lymphoid structure (TLS)"

Autor: Grafiati
Publicado: 23 de novembro de 2024
Última modificação: 31 de julho de 2025

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Artigos de revistas sobre o assunto "Tertiary lymphoid structure (TLS)"

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Gorecki, Grace, Lan Gardner Coffman, Sarah E. Taylor, and Tullia C. Bruno. "Tertiary lymphoid structure prevalence and prognostic value in cervical cancer." Journal of Clinical Oncology 41, no. 16_suppl (2023): e17521-e17521. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e17521.

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e17521 Background: Recurrent or progressive cervical cancer have limited second-line treatment options. Response rates are often poor to second-line therapy (average response rate of 15%). Identification of factors which predict response to immunotherapy and targets to enhance the immune response are critically needed in cervical cancer. Chronic inflammation can initiate an immune response in non-secondary lymphoid organs (SLO) and form a Tertiary Lymphoid Structure (TLS). TLS is composed of immune cells clustered and organized and responsible for immune cell chemotaxis, which impacts cancer t
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Amwas, Nour, Darya Alizadeh, Christine Brown, et al. "Abstract A038: Inducing tumor associated tertiary lymphoid structures using cellular therapy." Cancer Immunology Research 13, no. 2_Supplement (2025): A038. https://doi.org/10.1158/2326-6074.io2025-a038.

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Abstract Targeting the tumor microenvironment (TME) to be more immune permissive is a potential strategy for enhancing immunotherapies, such as chimeric antigen receptor T cell (CAR-T) therapy, providing a promising avenue for treating aggressive tumors such as glioblastoma multiforme (GBM). Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that arise in response to chronic inflammation and mimic the structure and function of secondary lymphoid organs. The spontaneous presence of TLS in some solid tumors, including GBM, is associated with improved clinical outcome and responsi
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Zou, Ji’an, Yingzhe Zhang, Yue Zeng, et al. "Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy." Cancers 14, no. 23 (2022): 5968. http://dx.doi.org/10.3390/cancers14235968.

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A tertiary lymphoid structure (TLS) is a special component in the immune microenvironment that is mainly composed of tumor-infiltrating lymphocytes (TILs), including T cells, B cells, DC cells, and high endothelial venules (HEVs). For cancer patients, evaluation of the immune microenvironment has a predictive effect on tumor biological behavior, treatment methods, and prognosis. As a result, TLSs have begun to attract the attention of researchers as a new potential biomarker. However, the composition and mechanisms of TLSs are still unclear, and clinical detection methods are still being explo
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Lynch, Kevin T., Samuel J. Young, Max O. Meneveau, et al. "Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma." Journal for ImmunoTherapy of Cancer 9, no. 6 (2021): e002273. http://dx.doi.org/10.1136/jitc-2020-002273.

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BackgroundTertiary lymphoid structures (TLSs) are immune aggregates in peripheral tissues that may support adaptive immune responses. Their presence has been associated with clinical response to checkpoint blockade therapy (CBT), but it is unknown whether TLS have prognostic significance independent of CBT in melanoma. We hypothesized that TLS in melanoma metastases would be associated with increased intratumoral lymphocyte infiltration, but that the intra-TLS immunological milieu would be distinct from the intratumoral immunological milieu. We also hypothesized that the presence of TLS would
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Nayar, Saba, Joana Campos, Charlotte G. Smith, et al. "Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology." Proceedings of the National Academy of Sciences 116, no. 27 (2019): 13490–97. http://dx.doi.org/10.1073/pnas.1905301116.

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Resident fibroblasts at sites of infection, chronic inflammation, or cancer undergo phenotypic and functional changes to support leukocyte migration and, in some cases, aggregation into tertiary lymphoid structures (TLS). The molecular programming that shapes these changes and the functional requirements of this population in TLS development are unclear. Here, we demonstrate that external triggers at mucosal sites are able to induce the progressive differentiation of a population of podoplanin (pdpn)-positive stromal cells into a network of immunofibroblasts that are able to support the earlie
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Yu, Jinglu, Yabin Gong, Xiaowei Huang, and Yufang Bao. "Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer." PeerJ 12 (October 31, 2024): e18401. http://dx.doi.org/10.7717/peerj.18401.

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The role of tertiary lymphoid structures (TLS) in oncology is gaining interest, particularly in colorectal carcinoma, yet a thorough analysis remains elusive. This study pioneered a novel TLS quantification system for prognostic and therapeutic response prediction in colorectal carcinoma, alongside a comprehensive depiction of the TLS landscape. Utilizing single-cell sequencing, we established a TLS score within the Tumor Immune Microenvironment (TIME). Analysis of tertiary lymphoid structure-related genes (TLSRGs) in 1,184 patients with colon adenocarcinoma/rectum adenocarcinoma (COADREAD) fr
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Boulat, Victoire, Elena Alberts, Carin Andrea Brundin, Dinis P. Calado, and Anita Grigoriadis. "Abstract 1375: Active inhibition of chemokine-mediated migration impairs tertiary lymphoid structure formation." Cancer Research 85, no. 8_Supplement_1 (2025): 1375. https://doi.org/10.1158/1538-7445.am2025-1375.

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Abstract The presence of tumor-infiltrating B cells (TIL-B) and tertiary lymphoid structures (TLS) in the primary tumor microenvironment carries prognostic value across cancer types. We have shown that triple-negative breast cancer (TNBC) patients with robust germinal center (GC) responses in their lymph nodes (LN) exhibit higher levels of TILs and more TLS. In this study, we investigated human and mouse immune-cold TNBCs to uncover mechanisms by which tumor-LN crosstalk may be impaired. In orthotopic TNBC mouse models, we observed robust GC responses in tumor-draining LNs. However, minimal TI
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Tang, Weilong, Chaiyaporn Kuwentrai, Matthew J. Webber, Zhou Ye, and Jiandong Huang. "Abstract 862: Dynamic hydrogel drug delivery systems for enhancing tertiary lymphoid structure formation and maturation." Cancer Research 85, no. 8_Supplement_1 (2025): 862. https://doi.org/10.1158/1538-7445.am2025-862.

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Introduction: Tertiary lymphoid structures (TLSs), also known as ectopic lymphoid structures, are organized lymphoid-like aggregates that can form within the tumor microenvironment. TLSs exhibit similar structural and functional characteristics to secondary lymphoid organs, such as lymph nodes, and are associated with improved cancer prognosis and enhanced immune responses, including immune checkpoint blockade (ICB) therapies. However, inducing mature TLSs remains a significant challenge. Our study aims to develop a dynamic hydrogel drug delivery system that stimulates the formation and matura
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Gonzalez, Ricardo A. Chaurio, Kyle K. Payne, Carmen Maria Anadon Galindo, et al. "Satb1 deficiency licenses TFH-differentiation and Tertiary Lymphoid Structure formation in cancer." Journal of Immunology 204, no. 1_Supplement (2020): 89.2. http://dx.doi.org/10.4049/jimmunol.204.supp.89.2.

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Abstract Tertiary Lymphoid Structures (TLS) are commonly identified in human tumors with improved outcome, but how they are orchestrated remains elusive. Here we show that silencing of the master genomic organizer Satb1 results in enhanced antigen-specific T Follicular Helper (TFH) differentiation. Increased TFH thereby promoted antigen-specific intra-tumoral CD19+B220+ B cell responses and spontaneous TLS assembly upon ovarian tumor challenge. Mechanistically, Satb1 deficiency drives increased TFH formation through de-repression of ICOS and PD-1. Accordingly, TGF-β1-driven downregulation of S
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Chung, Shin-Yi, Yi-Chen Yeh, Chien-Jung Huang, et al. "Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma." Journal for ImmunoTherapy of Cancer 13, no. 1 (2025): e010173. https://doi.org/10.1136/jitc-2024-010173.

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BackgroundCholangiocarcinoma is a challenging malignancy with limited responses to conventional therapies, particularly immune checkpoint inhibitor therapy. Tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) are key components of the tumor microenvironment (TME) and have been implicated in the immune response to cancer. However, the role and difference of TLSs and TILs in patients with cholangiocarcinoma remains unclear. This study elucidates their contributions to the TME.MethodsWe examined 16 tumor samples from a single-arm, phase II trial of nivolumab plus modifie
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Teses / dissertações sobre o assunto "Tertiary lymphoid structure (TLS)"

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Houel, Ana. "Étude de l’induction de structures lymphoïdes tertiaires, par virothérapie oncolytique, pour stimuler l’immunité antitumorale endogène." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS232.

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Les structures lymphoïdes tertiaires (TLS) sont des agrégats organisés de cellules immunitaires qui se développent dans les tissus non-lymphoïdes à la suite d'une inflammation chronique. Les TLS matures, dont l'organisation est proche de celle d'un ganglion, sont associées à un bon pronostic dans les cancers à tumeurs solides et servent de prédicteur efficace de la réponse des patients traités par immunothérapie. Notre objectif a été d'étudier la virothérapie oncolytique comme stratégie pour induire des TLS dans le microenvironnement tumoral (TME) afin d'intensifier les réponses antitumorales.
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Devi, Priyanka. "Role and prognostic importance of regulatory T cells in lung cancer patients, according to the presence of tertiary lymphoid structures." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066345/document.

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Une tumeur est un environnement complexe comprenant à la fois des composants immunitaires et non immunitaires. Dans notre équipe, nous avons démontré précédemment le rôle des structures lymphoïdes tertiaires (TLS) dans les cancers du poumon, dans la génération de réponses anti-tumorales protectrices. Cependant, les tumeurs peuvent se développer en utilisant des mécanismes d’immunosuppression tels que l’infiltration des cellules T régulatrices (Tregs) dans le microenvironnement tumoral. Cette thèse a étudié le mécanisme présumé des Tregs dans la régulation des réponses immunitaires dans le canc
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Kaplon, Hélène. "Rôle des lymphocytes B associés aux structures lymphoïdes tertiaires dans la réponse clinique des patients atteints d’un cancer pulmonaire Cancer-Associated Tertiary Lymphoid Structures, from Basic Knowledge Toward Therapeutic Target in Clinic Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS565.

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Le microenvironnement tumoral est un acteur majeur du contrôle immunitaire du développement tumoral. Ce contrôle commence à distance des cellules tumorales, dans le stroma tumoral, au sein de structures appelées structures lymphoïdes tertiaires (TLS), composées d'une zone de lymphocytes B (LB) où se trouvent principalement des lymphocytes B (LB) adjacents à une zone T. Nos précédents résultats ont mis en évidence que la zone B des TLS peut être un site de différenciation des LB en LB mémoires et plasmocytes (PC), sécrétant principalement des IgA et IgG chez les patients atteints de cancer du p
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Le, Rochais Marion. "Cancer colorectal : apport pronostique de l’étude pathomique du microenvironnement tumoral. Focus sur les structures lymphoïdes tertiaires." Electronic Thesis or Diss., Brest, 2024. http://www.theses.fr/2024BRES0044.

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Le cancer colorectal est devenu un défi majeur pour les systèmes de santé en raison de sa prévalence croissante et de son impact sur la qualité de vie des patients. L'analyse anatomopathologique des prélèvements de cancer colorectal, désormais enrichie de données de pathologie moléculaire, est cruciale pour orienter le traitement des patients. Malgré les avancées dans les outils pronostiques et les traitements, les interactions entre les cellules tumorales et immunitaires du microenvironnement tumoral ne sont souvent pas évaluées de manière exhaustive en pratique diagnostique quotidienne. Cett
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Capítulos de livros sobre o assunto "Tertiary lymphoid structure (TLS)"

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Klein, Christophe, Priyanka Devi-Marulkar, Marie-Caroline Dieu-Nosjean, and Claire Germain. "Development of Tools for the Selective Visualization and Quantification of TLS-Immune Cells on Tissue Sections." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_4.

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Louveau, Antoine. "Meningeal Immunity, Drainage, and Tertiary Lymphoid Structure Formation." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_3.

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Devi-Marulkar, Priyanka, Hélène Kaplon, Marie-Caroline Dieu-Nosjean, and Myriam Lawand. "Designed Methods for the Sorting of Tertiary Lymphoid Structure-Immune Cell Populations." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_11.

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Gu-Trantien, Chunyan, Soizic Garaud, Edoardo Migliori, Cinzia Solinas, Jean-Nicolas Lodewyckx, and Karen Willard-Gallo. "Quantifying Tertiary Lymphoid Structure-Associated Genes in Formalin-Fixed Paraffin-Embedded Breast Cancer Tissues." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_9.

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Couillault, Coline, Claire Germain, Bertrand Dubois, and Hélène Kaplon. "Identification of Tertiary Lymphoid Structure-Associated Follicular Helper T Cells in Human Tumors and Tissues." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_12.

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Gutierrez-Chavez, Claudia, Samantha Knockaert, Marie-Caroline Dieu-Nosjean, and Jérémy Goc. "Development of Methods for Selective Gene Expression Profiling in Tertiary Lymphoid Structure Using Laser Capture Microdissection." In Tertiary Lymphoid Structures. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8709-2_8.

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MacFawn, Ian P., and Tullia C. Bruno. "Tertiary Lymphoid Structure Formation and Function in the Tumor Microenvironment." In Handbook of Cancer and Immunology. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-030-80962-1_83-1.

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Gutierrez-Chavez, Claudia, Samantha Knockaert, Marie-Caroline Dieu-Nosjean, and Jeremy Goc. "Methods for Selective Gene Expression Profiling in Single Tertiary Lymphoid Structure Using Laser Capture Microdissection." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-4184-2_6.

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Klein, Christophe, Priyanka Devi-Marulkar, Marie-Caroline Dieu-Nosjean, and Claire Germain. "Advancement of Techniques for Precise Visualization and Quantification of Tertiary Lymphoid Structure-Associated Immune Cells in Tissue Samples." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-4184-2_10.

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Nicolini, Fabio, and Massimiliano Mazza. "The Immune System of Mesothelioma Patients: A Window of Opportunity for Novel Immunotherapies." In Rare Diseases [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98617.

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The interplay between the immune system and the pleural mesothelium is crucial both for the development of malignant pleural mesothelioma (MPM) and for the response of MPM patients to therapy. MPM is heavily infiltrated by several immune cell types which affect the progression of the disease. The presence of organized tertiary lymphoid structures (TLSs) witness the attempt to fight the disease in situ by adaptive immunity which is often suppressed by tumor expressed factors. In rare patients physiological, pharmacological or vaccine-induced immune response is efficient, rendering their plasma
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Trabalhos de conferências sobre o assunto "Tertiary lymphoid structure (TLS)"

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Sonntag, M., C. Brunner, and TK Hoffmann. "Analyses of germinal center B cells and tertiary lymphoid structures (TLS) in mouse and human HNSCC." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686078.

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Ukita, Masayo, Junzo Hamanishi, Tsukasa Baba, Ryusuke Murakami, Kaoru Abiko, and Masaki Mandai. "Abstract 1021: Clinical significance of tertiary lymphoid structures (TLS) and tumor-infiltrating plasma cells in ovarian cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1021.

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Iding, Jeff, Paul VanderLaan, Marcelo Jimenez, et al. "702 Tertiary lymphoid structures (TLS) observed in non-small cell lung cancer (NSCLC) tumors treated with pulsed electric fields." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0702.

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Hamanishi, Junzo, Haruka Suzuki, Akihiko Ueda, Ken Yamaguchi, and Masaki Mandai. "SO016/#846 Deep learning for spatial distribution of tertiary lymphoid structures (TLS) and efficacy of immunotherapy for endometrial cancer." In IGCS 2023 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/ijgc-2023-igcs.30.

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Downey, Kira Morgan, Bindu Hegde, Zinal Chheda, Jason Zhang, and Hideho Okada. "Abstract 74: Engineering tertiary lymphoid structures for glioblastoma: A novel gene combination promotes therapeutic TLS formation in an immune-competent mouse model of GBM." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-74.

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Srivastava, Minu K., Velimir Gayevskiy, Vy Ma, et al. "606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0606.

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Guo, Phoebe, Eshed Margalit, Daniel Bear, et al. "861 Multimodal foundation model of human lung tumors identifies tertiary lymphoid structures (TLS) and reveals novel therapeutic targets that promote anti-tumor immune response." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.0861.

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Fontaine, C., G. Van den Eynden, R. de Wind, et al. "Abstract P2-08-47: Evaluation of stromal tumor-infiltrating lymphocytes (sTIL) and tertiary lymphoid structures (TLS) in early breast cancer patients with triple negative breast cancer(TNBC) included in a prospective study of neoadjuvant chemotherapy (NAC) with Epirubicin and cyclophosphamide (EC) and carboplatin-paclitaxel (PC) (BSMO 2014-01)." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p2-08-47.

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Karapetyan, Lilit, Xi Yang, Hong Wang, et al. "Abstract 2683: Serum multiplex analysis of tertiary lymphoid structure-associated chemokines/cytokines in melanoma patients." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2683.

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Liu, Dongyan, Xiang Li, Rajesh Acharya, et al. "Abstract PO-083: Utilizing spatial transcriptomics to elucidate tertiary lymphoid structure heterogeneity in human cancer." In Abstracts: AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact; September 17-18, 2020. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.tumhet2020-po-083.

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Relatórios de organizações sobre o assunto "Tertiary lymphoid structure (TLS)"

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Lin, Liying, Min Li, Bo Fu, et al. Association between tertiary lymphoid structure and HNSCC: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.8.0031.

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