Siga este link para ver outros tipos de publicações sobre o tema: Strong Lead.

Teses / dissertações sobre o tema "Strong Lead"

Crie uma referência precisa em APA, MLA, Chicago, Harvard, e outros estilos

Selecione um tipo de fonte:

Veja os 34 melhores trabalhos (teses / dissertações) para estudos sobre o assunto "Strong Lead".

Ao lado de cada fonte na lista de referências, há um botão "Adicionar à bibliografia". Clique e geraremos automaticamente a citação bibliográfica do trabalho escolhido no estilo de citação de que você precisa: APA, MLA, Harvard, Chicago, Vancouver, etc.

Você também pode baixar o texto completo da publicação científica em formato .pdf e ler o resumo do trabalho online se estiver presente nos metadados.

Veja as teses / dissertações das mais diversas áreas científicas e compile uma bibliografia correta.

1

Hluchan, Sarah Kathleen. "Smart growth for strong communities which existing smart growth features lead to highly desirable neighborhoods? /". Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/444620211/viewonline.

Texto completo da fonte
Estilos ABNT, Harvard, Vancouver, APA, etc.
2

D'Amico, Samantha. "HMHS Royal Comfort". Digital Commons at Loyola Marymount University and Loyola Law School, 2021. https://digitalcommons.lmu.edu/etd/979.

Texto completo da fonte
Resumo:
HMHS Royal Comfort is a one-hour drama about a young Army nurse named Eleanor Allen who gets assigned to the newly commissioned hospital ship, HMHS Royal Comfort, during the beginning of World War 1. Eleanor, along with the other Army nurses, volunteers, and Royal Army Medical Corp officers must treat, care for, and save the wounded soldiers who board their ship as they push aside their own personal secrets amidst the growing conflict.
Estilos ABNT, Harvard, Vancouver, APA, etc.
3

Blad, Eleonor, e Lykke Paulsson. "Lean implementering ur ett medarbetarperspektiv : En kvalitativ fallstudie om faktorer som påverkar medarbetares arbetsmiljö vid implementering av lean". Thesis, Högskolan i Gävle, Avdelningen för ekonomi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-36404.

Texto completo da fonte
Resumo:
Syfte: Syftet är att skapa förståelse för den påverkan som implementering av lean har på arbetsmiljön ur ett medarbetarperspektiv. Metod: Studien genomförs som en kvalitativ fallstudie enligt hermeneutiskt tolkningsperspektiv där primärdata samlas in genom semistrukturerade intervjuer. Sekundärdata har huvudsakligen samlats in genom vetenskapliga artiklar och litteratur på området. Resultat & slutsats: Studien visar att implementering av lean påverkar medarbetarnas arbetsmiljö och att faktorer som delaktighet, kommunikation, utbildning och inte minst ledarskapet är viktiga faktorer för en god arbetsmiljö. En initial motvilja har efterhand som konceptet inarbetats bytts ut mot en positiv inställning och ett nytt sätt att arbeta. Examensarbetets bidrag: Studien bidrar till att skapa förståelse för hur implementering av lean påverkar arbetsmiljön. Genom förståelse för hur externa strukturer påverkar interna strukturer och därigenom medarbetarnas agerande vill vi belysa vilka faktorer som företag bör rikta fokus mot för att bibehålla en god arbetsmiljö under implementering av lean. Studiens resultat kan inte direkt generaliseras till andra arbetsplatser, men erbjuder en möjlighet att testa samma metod för att se hur arbetsmiljön påverkas. Förslag till fortsatt forskning: Studien är relativt liten och medarbetarna har arbetat tillsammans under lång tid, därför kan framtida studier med fördel utföras på företag med större personalomsättning, annat företag i servicebranschen eller som en jämförande studie mellan två olika företag för att se påverkan på arbetsmiljön.
Aim: The aim of the study is to create understanding of the implications of lean implementation on the work environment seen from the coworker perspective Method: Qualitative case study with primary data collected by interviews of managers and employees at ICA Maxi Special in two different cities. Secondary data was collected from scientific articles and relevant literature regarding previous research in the field. Result & Conclusions: The study reveals that implementation of lean affects the coworkers' perceived work environment and that factors such as participation, meaningfulness, autonomy, communication and education are important factors for a good work environment. The initial reluctance experienced by coworkers when implementing the concept was later exchanged for a positive attitude and a new way of work, which consequently led to a better working environment in general. Contribution of the thesis: The findings of this study contribute to research by understanding and highlighting the factors that influence the employees work environment. By understanding the effect of external structures, such as lean and how it affects internal structures, and such as the actions and reactions of coworkers, companies can mitigate the impact on the work environment when implementing lean. Suggestions for future research: The study is rather small and conducted at a workplace where most of the employees have worked together for several years. Therefore, we suggest that future studies can be conducted at companies with a larger employee turnover, or at a different type of company in the service industry, or as a comparative study between
Estilos ABNT, Harvard, Vancouver, APA, etc.
4

Claeson, Mikael. "Mixing strings of Lithium-Ion and Lead-Acid in parallel". Thesis, Mittuniversitetet, Institutionen för elektronikkonstruktion, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-39400.

Texto completo da fonte
Resumo:
The purpose of this survey has been to test and analyse the behaviour of battery systems mixing parallel strings of lithium and lead acid. The underlying theory of why batteries of different chemistries behaves together was investigated in order to understand the resulting tests. Several tests were made with different products, loads and chargers in order to confirm this theory and to discover cases where the system works good and where it works bad. Based on this understanding a script was made in order to find a point of the least annual cost. Annual cost was then compared with systems of Lead acid only and Lithium only. The final goal for the script was so that a salesman can input known parameters for a backup site. Script is then adding a small Lithium battery in parallel with a fixed Lead acid battery and, increasing Lithium in size and estimating depth of discharge for Lithium and Lead acid at each step, until desired breakpoint. A point of minimum system cost together with Li size is then represented together with the recommended current limits.
Avsikten med detta exjobb har varit att testa och analysera beteendet av batteri-system där man blandar litium och bly parallellt. Den underliggande teorin om varför batterier av olika kemier beter sig på ett visst sätt tillsammans undersöktes för att få en förståelse för testresultaten. Ett flertal tester gjordes med olika batterier, laster och laddare för att verifiera teorin och för att upptäcka fall där systemet funkar bra och där det funkar dåligt. Baserat på denna förståelse gjordes ett script med avsikten att hitta en punkt med en lägsta årlig kostnad. Denna kostnad jämfördes sedan med system bestående av enbart bly samt enbart litium. Det slutgiltiga målet med scriptet var att en säljare ska kunna fylla i kända parametrar för en viss telekom-anläggning. Scriptet lägger sedan till ett litet Litium-batteri parallellt med ett konstant bly-batteri. För att sedan öka på Litium i storlek och uppskatta urladdningsdjupet för Litium och bly vid varje steg, tills dess att Li har samma storlek som bly. En punkt för minsta kostnaden presenteras sedan tillsammans med optimal storlek av Litium samt rekommenderade max-strömmar.
Estilos ABNT, Harvard, Vancouver, APA, etc.
5

Gilliom, Michael B. "Use of SIMO Converstion for Optimizing LED Light Drivers". Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/76876.

Texto completo da fonte
Resumo:
As a growth industry, tremendous cost pressures are pushing the LED lighting market away from traditional power electronics converters and towards solutions that are more unconventional. Lower quality LED lights use simple low-cost converters, whereas high end product may add complexity in order to achieve a more dramatic energy savings. SIMO technology represents an opportunity in LED lighting to combine the low cost of single-stage converters with the energy saving capability of a two-stage, multiple string solution. This paper describes the modeling, analysis, design, and testing of a Multiple Independently Regulated Output Flyback (MIROF) converter, used in LED lighting for the purpose of multiple string control. This converter is based upon SIMO technology applied to a PFC Flyback converter. The result was the development of a novel control method and an operational demonstration unit. A cost comparison of the MIROF and a conventional two-stage driver shows a promising cost reduction benefit for the former, and comparative testing shows favorable performance of the MIROF converter compared to the two-stage approach.
Master of Science
Estilos ABNT, Harvard, Vancouver, APA, etc.
6

Antonakakis, Nikolaos, Mina Dragouni e George Filis. "How Strong is the Linkage between Tourism and Economic Growth in Europe?" Elsevier, 2015. http://dx.doi.org/10.1016/j.econmod.2014.10.018.

Texto completo da fonte
Resumo:
In this study, we examine the dynamic relationship between tourism growth and economic growth, using a newly introduced spillover index approach. Based on monthly data for 10 European countries over the period 1995-2012, our analysis reveals the following empirical regularities. First, the tourism-economic growth relationship is not stable over time in terms of both magnitude and direction, indicating that the tourism-led economic growth (TLEG) and the economic-driven tourism growth (EDTG) hypotheses are time-dependent. Second, the aforementioned relationship is also highly economic event-dependent, as it is influenced by the Great Recession of 2007 and the ongoing Eurozone debt crisis that began in 2010. Finally, the impact of these economic events is more pronounced in Cyprus, Greece, Portugal and Spain, which are the European countries that have witnessed the greatest economic downturn since 2009. Plausible explanations of these results are provided and policy implications are drawn. (authors' abstract)
Estilos ABNT, Harvard, Vancouver, APA, etc.
7

Barton, Robert Allan. "Multi-strange hyperon production in relativistic heavy -ion collisions". Thesis, University of Birmingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367744.

Texto completo da fonte
Estilos ABNT, Harvard, Vancouver, APA, etc.
8

Villalva, Nicholas E. "Design, construction and analysis of an LED strobe controller". Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/85515.

Texto completo da fonte
Resumo:
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (page 51).
In this thesis, I describe an LED strobe controller that I designed and built. With the advent of much brighter LEDs, it is possible to create stroboscopes with both high intensity output and high maximum flash rates. Additionally, the proliferation of Wi-Fi enabled devices provokes the idea of a next-generation interface for tools in Strobe Lab. The initial goal was to produce an LED-based strobe that has sufficient light to replace existing flash tube stroboscopes. The final product combines three high powered LEDs with a microcontroller and Wi-Fi card. Users can adjust settings through a web based interface accessible from both laptops and mobile devices. In addition to the simple user interface, the controller is compatible with other equipment in Strobe Lab as it can be triggered by the commonly used methods. Established techniques, such as sync and delay, and newer techniques, such as color-encoded multi-flash images, are possible with this device.
by Nicholas E. Villalva.
M. Eng.
Estilos ABNT, Harvard, Vancouver, APA, etc.
9

Sperry, Robert George. "DEVELOPMENT OF A SEMI-AUTOMATED TOBACCO STRIPPING MACHINE UTILIZING STRING TRIMMERS". UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_theses/89.

Texto completo da fonte
Resumo:
Conventional stripping of burley tobacco is labor intensive and typically requires 50 to 75 worker hours per acre (wkr•hr/ac). The goal of the project was to reduce labor by optimizing leaf removal by string trimmer heads using combinations of strings lengths and motor speeds. In tests conducted on a single grade, all leaves outside the grade were removed by hand. Plants were run through the machine for sting lengths of 5, 7 and 9 inches and associated motor speeds which were monitored and recorded. Stripping efficiencies were calculated for each plant and collectively for each set of four plants. The machine was then tested for three grade stripping efficiency. Particle size analysis tests were run to determine potential losses due to leaf shredding. Efficiencies for single grade testing ranged from 93 to 96% for optimal string length and speed combinations. Stripping three grades by machine resulted in an average of 97% efficiency. Potential losses due to shredding accounted for 5.6% of the total weight mechanically removed. It is believed that this stripping concept, implemented on a full scale four grade basis, could result in savings of at least 18 wkr •hr/ac [45 wkr•hr/ha].
Estilos ABNT, Harvard, Vancouver, APA, etc.
10

Pickering, Mary Theresa. "Rb Inactivation Leads to E2F1-mediated DNA Double Strand Break Accumulation: A Dissertation". eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/26.

Texto completo da fonte
Resumo:
Although it is unclear which cellular factor(s) is responsible for the genetic instability associated with initiating and sustaining cell transformation, it is known that most, if not all, cancers have mutations that inactivate the Rb-mediated growth control pathway. We show here that acute inactivation of Rb by RNA interference or expression of the E7 viral oncoprotein from human papillomavirus (HPV), and the resultant deregulation of one E2F family member, E2F1, leads to DNA double strand break (DSB) accumulation. These DSBs occur independent of apoptosis induction, and activation of ATM, NBS1, p53, or MAD2, and generation of reactive oxygen species (ROS). Although ROS accumulation is associated with DSBs generated from the mis-expression of another nuclear oncoprotein, c-MYC, we find that E2F1 does not contribute to c-MYC associated DSBs, indicating that the DSBs associated with these oncoproteins arise through distinct pathways. However, we find that small changes in E2F1 levels by inhibition of c-MYC transactivated microRNAs known to limit E2F1 protein expression, lead to DSB accumulation. These results suggest that despite the DSBs arising by different mechanisms, c-MYC assists in the regulation of E2F1-associated DSBs. We also find elevated levels of E2F1-associated DSBs in Rb mutated cancer cell lines in the absence of an exogenous DSB stimulus. These basal, E2F1-associated DSBs are substantially lower in Rb wildtype cancer cell lines that have p16ink4 inactivated or express HPV E7. However, we show that we can manipulate DSB levels in these cancer cell lines by modulating Rb and E2F1 activity and suggest that these results may be extended to breast tumor organ culture. Thus, Rb status is key to regulating both the proliferation promoting functions associated with E2F and for preventing DNA damage accumulation if E2F1 becomes deregulated. Taken together, these data suggest that loss of Rb creates strong selective pressure, via DSB accumulation, for inactivating p53 mutations and that E2F1 might contribute to the genetic instability associated with transformation and tumorigenesis.
Estilos ABNT, Harvard, Vancouver, APA, etc.
11

Strong, Austin Michael. "Lean Six Sigma's Impact on Firm Innovation Performance". BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/6877.

Texto completo da fonte
Resumo:
Following Toyota's dramatic rise to prominence within the automotive industry in the late 1980's, firms around the globe have widely sought to adopt Lean Six Sigma (LSS) as a means of reducing costs, improving quality, and gaining an overall competitive advantage. While the operational benefits of LSS are largely undisputed, there are criticisms of the movement with regards to its effect on firm innovation capability. Prior academic studies investigating the relationship between LSS and innovation are largely conceptual in nature, rely heavily on qualitative data, and display a high degree of variability in results. The objective of this work was to empirically confirm whether LSS adoption had a positive, negative, or neutral impact on firm innovation performance.Financial data was collected for 151 publicly traded firms over the period from 1985 to 2018. The year of company-wide adoption of LSS was identified for each sample firm. Firms were paired with industry rivals using Coarsened Exact Matching (CEM), and statistical regressions were performed to show correlations between LSS implementation (as measured by inventory turns) and innovation performance (as measured by Total Factor Productivity, Research Quotient, and Tobin's Quotient). Regression results indicated that LSS implementation had a positive correlation with firm process innovation performance and the overall market perception of firm innovation and value, and a negative-to-neutral correlation with firm product innovation performance. Additional regressions performed at the industry-sector level revealed that the LSS-innovation relationship varies greatly by industry environment and is subject to unique industry effects and management implementation decisions.
Estilos ABNT, Harvard, Vancouver, APA, etc.
12

SWAMINATHAN, MOHAN. "CONTRIBUTIONS TO ENHANCE PRACTICAL IMPLEMENTATION OF LEAN MANUFACTURING IN INDUSTRIAL ENVIRONMENTS". UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_theses/368.

Texto completo da fonte
Resumo:
Traditionally manufacturing job shops either have a process layout or a product layout. The advantages of one type of layout tend to be a disadvantage for the other. Hybrid cellular constructs represents a novel fusion of process and product layouts. In this thesis, hybrid cellular constructs specifically Hybrid Flow Shops and Reoriented andamp; Reshaped Cells are clearly described in terms of their structure, key features, and modes of operation. An engineering procedure is illustrated by cases and particular manufacturing circumstances where each concept would be most useful are identified. This thesis then defines the lean practices that are compatible with the structure in question and identifies what practices are incompatible. It suggests how to modify lean practices to fit and at least obtain some benefits for the incompatible ones. Finally, a procedure for design of logistics management systems for assembly cells and lines is presented.
Estilos ABNT, Harvard, Vancouver, APA, etc.
13

Xie, Hong. "Misrepair of Particulate Chromium(VI)-Induced DNA Double Strand Breaks Leads to Neoplastic Transformation". Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/XieH2007.pdf.

Texto completo da fonte
Estilos ABNT, Harvard, Vancouver, APA, etc.
14

Bentley, Danielle Sarah. "Restrung new chamber festival : an exploration of contemporary string practice". Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/49582/1/Danielle_Bentley_Thesis.pdf.

Texto completo da fonte
Resumo:
The Restrung New Chamber Festival was a practice-led research project which explored the intricacies of musical relationships. Specifically, it investigated the nature of contemporary string practice, with "New music" at its core. For the purposes of this project, "New music" will be defined in terms of representing a "global sonorous space" (Nancy 2007:12), which Hulse describes as "a spectacular comingling of styles and an unprecedented explosion of creative possibilities" (Hulse n.d.:2). Approaches to staging such an event are contextualised through a comparative analysis with relevant Australian and European festivals. The Restrung model derived inspiration from both art music and popular music festival models, in several aspects. One strategy was to engage audiences through combinations of musical, visual and spatial features. Another strategy was to encourage interaction by audiences with installations, workshops and forums. Restrung represents a new and distinctive model which presented art music within an immersive environment. This exegesis presents an evaluation framework which investigates the relationship between curatorial input and the experiential qualities of the festival. The context of an overview of trends in arts festival curation informs the discussion, as well as approaches to identifying new and receptive audiences. It is expected that the evaluation framework will provide a useful and practical guide for curators working in contemporary string practice, hybrid arts, experimental and cross-art form festival design.
Estilos ABNT, Harvard, Vancouver, APA, etc.
15

Hamon, Julien. "Etude de la production des mésons charmés-étranges dans les collisions proton-proton et proton-plomb avec l'expérience ALICE au LHC". Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAE012/document.

Texto completo da fonte
Resumo:
L'étude de la production des quarks charmés dans les collisions de hautes énergies de noyaux atomiques offre une approche inédite pour l'étude du plasma de quarks et de gluons. La compréhension et la caractérisation de cet état de la matière déconfinée, de prime abord retrouvé dans les systèmes les plus lourds, nécessitent une connaissance fine des systèmes les plus légers, telles que les collisions proton-proton (pp) et proton-plomb (p-Pb). Dans ce manuscrit, nous présentons la mesure de la production des mésons charmés-étranges Ds+, à rapidité centrale, avec les données du run 2 du LHC, recueillies en 2016 par l'expérience ALICE. Deux systèmes sont étudiés : les collisions pp à √s=13 TeV et p-Pb à √sNN=5,02 TeV. La section efficace de production des Ds+, leur abondance relative et leur facteur de modification nucléaire sont mesurés puis comparés à d'autres mesures et à diverses prédictions théoriques. Le résultat p-Pb établit une nouvelle référence pour l'étude des collisions Pb-Pb
The study of the production of charm quarks in high-energy atomic-nucleus collisions offers an genuine approach for the study of the quark-gluon plasma. The understanding and characterisation of this state of deconfined-matter, at first sight created in heaviest systems, require a fine knowledge of lightest systems, such as proton-proton (pp) and proton-lead (p-Pb) collisions. In this manuscript, we present the measurement of the charm-strange mesons Ds+ production, at central rapidity, with the LHC run 2 data, collected in 2016 with the ALICE experiment. Two systems are studied: pp collisions at √s=13 TeV and p-Pb collisions at √sNN=5.02 TeV. The production cross-section of Ds+, their relative abundance and their nuclear modification factor are measured then compared to other measurements and to various theoretical predictions. The p-Pb result establishes a new reference for the study of Pb-Pb collisions
Estilos ABNT, Harvard, Vancouver, APA, etc.
16

Moussa, Angela. "Altering the level of lamin B1 leads to double-strand break repair defects and replicative stress". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS011.

Texto completo da fonte
Resumo:
La surexpression de la lamine B1, un composant majeur de l'enveloppe nucléaire, a été rapportée dans diverses tumeurs. Cependant, les causes et les conséquences de cette augmentation sur la stabilité du génome n'ont pas été étudiées à ce jour. En effet, l'instabilité du génome est considérée comme une caractéristique majeure des cellules cancéreuses. Pour assurer le maintien de la stabilité du génome, les cellules ont développé de multiples et complexes mécanismes parmi lesquels les voies de réparation de l'ADN et la gestion du stress réplicatif sont essentielles. Au cours de ma thèse, l'impact de l'augmentation de niveau de lamine B1 sur la stabilité du génome, en particulier sur la réparation de cassure double-brin (CDB) et sur le contrôle du stress réplicatif a été étudié. En effet, nous montrons qu'une augmentation de la lamine B1 entraîne une accumulation de CDB et leur persistance en réponse à l'irradiation (foyers γH2AX), en plus d'une sensibilité accrue à l'irradiation (formation de colonies et cassures chromosomiques). Les cellules surexprimant la lamine B1 montrent également des défauts de recrutement de 53BP1 aux sites de dommages d’ADN, couplés à une diminution de l'efficacité de la réparation de CDB par NHEJ (Non-Homologous End-Joining). De plus, nous avons identifié une interaction directe entre la lamine B1 et 53BP1 régulant le recrutement de ce dernier aux CDB. Nos résultats supportent un modèle dans lequel l'augmentation de la lamine B1 conduit à la séquestration de 53BP1, modifiant ainsi son recrutement aux CDBs. En parallèle, nous montrons que les cellules surexprimant la lamine B1 présentent des signes accrus de stress réplicatif tels que l'accumulation de foyers spontanés de p-RPA, l'augmentation des figures radiales lors du traitement par mitomycine C, et une sensibilité accrue au traitement par camptothécine. Nous avons en outre cherché à identifier les causes de l'augmentation du stress réplicatif dans ces cellules, et les conséquences potentielles, en particulier sur l'induction de phénotypes inflammatoires. En fait, nous montrons que la surexpression de la lamine B1 conduit à une diminution de l'efficacité de la réparation de CDB par la recombinaison homologue, couplée à un défaut de formation de foyers BRCA1 après irradiation. De plus, nous avons obtenu des données préliminaires suggérant une induction de l'inflammation lors de la surexpression de la lamine B1. En résumé, ce travail de Thèse a permis d’identifier un nouveau mécanisme régulant le recrutement de 53BP1 aux CDB par son interaction avec la lamine B1, et souligne le rôle de l'augmentation de la lamine B1 dans la promotion de l'instabilité génomique au moins partiellement par des défauts de réparation de CDB et une augmentation de stress réplicatif. Après confirmation de l'induction de phénotypes inflammatoires, nous aurions identifié des rôles de l'augmentation de la lamine B1 dans la promotion de deux caractéristiques majeures du cancer - l'instabilité génomique et l'inflammation - favorisant ainsi le rôle de la lamine B1 dans le développement tumoral et proposant cette dernière comme une cible thérapeutique antitumorale potentielle
The overexpression of lamin B1, a major component of nuclear envelope, has been reported in various tumors. However, the causes and consequences of this increase on the genome stability have not been studied to date. Indeed, genome instability is considered a major hallmark of cancer cells. To ensure the maintenance of genome stability, cells have developed multiple complex mechanisms among which pathways of DNA repair and replication stress management are essential. Therefore, during my thesis the impact of an increased lamin B1 level on genome stability, in particular on double-strand break (DSB) repair and on the control of replication stress was studied. Indeed, we show that increased lamin B1 leads to an accumulation of DSBs and their persistence in response to irradiation (γH2AX foci), in addition to an increased sensitivity to irradiation (colony formation and chromosomal breaks). Lamin B1 overexpressing cells also show defects in the recruitment of 53BP1 to damage sites, coupled to a decreased efficiency of DSB repair by Non-Homologous End-Joining. Moreover, we identified a direct interaction between lamin B1 and 53BP1 regulating the latter’s recruitment to DSBs. Our results support a model where increased lamin B1 leads to the sequestration of 53BP1, thereby altering its recruitment to DSBs. In parallel, we show that cells overexpressing lamin B1 display increased signs of replication stress such as accumulation of spontaneous p-RPA foci, increased radial chromosomes upon mitomycin C treatment, and enhanced sensitivity to treatment with camptothecin. We further aimed to identify the causes of the increased replication stress in these cells, in addition to the potential consequences, in particular on the induction of inflammatory phenotypes. In fact, we show that lamin B1 overexpression leads to a decreased efficiency of DSB repair by Homologous Recombination, coupled to a defect in irradiation-induced BRCA1 foci formation. In addition, we obtained preliminary data suggesting a possible induction of inflammation upon lamin B1 overexpression. Altogether, this work identifies a novel mechanism regulating the recruitment of 53BP1 to damage sites through its interaction with lamin B1, and highlights the role of increased lamin B1 in promoting genome instability at least partially through defective DSB repair and increased replication stress. Upon confirming the induction of inflammatory phenotypes, we would have identified roles of increased lamin B1 in promoting two major hallmarks of cancer – genomic instability and inflammation - thereby favorizing a role for lamin B1 in tumor development and proposing the latter as a potential anti-tumor therapeutic target
Estilos ABNT, Harvard, Vancouver, APA, etc.
17

Velehradský, Petr. "KVANTIFIKACE PŘESNOSTI MĚŘENÍ TLAKOVÝCH ZTRÁT PŘI HODNOCENÍ PÓROVITOSTI HLINÍKOVÝCH ODLITKŮ". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228020.

Texto completo da fonte
Resumo:
The diploma thesis deals with a matter of a leak testingo of the Schreiner devices in the company Kovolis Hedvikov a.s. The tested components are the heat exchangers made from alloy of aluminium used for automobiles. Due to the impact of porosity texture created during the components casting there is leaking. The analysis was accomplished to find out the most problematic parts of these components. Subsequently the testing and measuring were performed in order to classify the testing and detect its accuracy. The summary and suggested solutions of how to improve the accuracy of measuring of the aluminium components leaking are presented in the conclusion.
Estilos ABNT, Harvard, Vancouver, APA, etc.
18

Maikowski, Lea Friederike [Verfasser], e Karin [Akademischer Betreuer] Meißner. "Neuronal and behavioural pain processing : a comparison between a strong brand and a generic medication placebo using the example of Aspirin vs. 1A Pharma / Lea Friederike Maikowski ; Betreuer: Karin Meißner". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1153338416/34.

Texto completo da fonte
Estilos ABNT, Harvard, Vancouver, APA, etc.
19

Smeliková, Lenka. "Kontrola kvality pájeného spoje a Design of Experiments u strojního pájení vlnou". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220991.

Texto completo da fonte
Resumo:
This master´s thesis deals with problems of wave soldering and application methods Design of Experiments for the new product production. Summarizes the basic knowledge of soldering technology, of solder alloys and Design of Experiments methods. Design of Experiments method has been applied to product to find the optimal for wave soldering setting.
Estilos ABNT, Harvard, Vancouver, APA, etc.
20

Ben, Chaabane Faten. "Couplage entre émetteurs organiques et antennes optiques : perspectives pour l'éclairage et la signalisation automobile". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASP078.

Texto completo da fonte
Resumo:
Cette thèse est la première étape dans la conception d’une source de lumière visible cohérente mais non lasante pour des applications d’éclairage et de signalisation automobiles. Dans ce travail, différents aspects théoriques, numériques et expérimentaux ont été abordés. Ainsi, des structures combinant différents émetteurs organiques et des nanoantennes (NP) ont été réalisées et ont permis de démontrer d’une part une exaltation de la luminescence grâce aux résonances plasmons des antennes, et d’autre part, une signature de couplage fort. Aucune suppression d’émission de lumière (quenching) n’a été observée dans nos structures où les NP métalliques sont en contact direct avec la couche organique. Ces résultats sont prédits par la loi de Kirchhoff locale où les molécules de la couche organique sont dans le régime de thermalisation.Un outil de simulation numérique aux éléments finis a été développé pour étudier le couplage entre un milieu dipolaire actif et des nanoantennes plasmoniques dans une structure LED (Light Emitting Diode). Le modèle, dont la validité dépasse le cadre de cette thèse, permet d'inclure la réponse nonlinéaire du milieu dipolaire dans les simulations électromagnétiques effectuées dans le domaine fréquentiel. Enfin, un premier dispositif OLED (Organic LED) a été développé, comme étape préliminaire et incontournable vers une source cohérente étendue. Une suite possible à ces travaux serait d’optimiser l’OLED fabriquée et d’y insérer des nanoantennes, en contact avec la couche organique émettrice, pour la transformer en dispositif émettant de la lumière dans le régime du couplage fort et en présence d’un état collectif
This thesis is a first step to develop a novel class of coherent but non-lasing light sources in the visible range for automotive lighting and signaling applications. Several theoretical, numerical and experimental aspects have been addressed. Structures combining organic emitters and optical nanoantennas (NPs) have been fabricated to demonstrate, on the one hand, a luminescence enhancement due to the plasmonic resonances of the antennas, and, on the other hand, a signature of strong coupling. Our structures do not suffer from emission quenching despite the fact that the metallic NPs are in direct contact with the organic layer. These results are consistent with the local Kirchhoff law that applies when the molecules of theorganic layer are in the thermalization regime. A finite element model has been developed to study the coupling between an active dipolar medium and plasmonic nanoantennas in a Light Emitting Diode (LED) structure. This model makes it possible to include the nonlinear response of a two-level dipolar active medium in electromagnetic simulations in the frequency domain. Finally, a first OLED (Organic LED) device was also developed, as a preliminary and essential step towards an extended coherent source. A possible follow-up to this work will be to optimize the OLED and insert nanoantennas in its design, so as to transform the structure into a device emitting light in the strong coupling regime and in the presence of a collective state
Estilos ABNT, Harvard, Vancouver, APA, etc.
21

Schaerström, Fredrik. "Icke-fysiska fiskledare : En laborationsstudie för att utvärdera tre fiskledare av bubblor och strobeljus och deras funktion i att leda laxsmolt vid nedströmsvandring". Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140407.

Texto completo da fonte
Resumo:
Fiskars passager genom vattenkraftverk är förenat med hög dödlighet. För att minska vattenkraftens påverkan på fiskbestånd har olika fiskledare utvecklats. I denna laboratoriestudie utvärderades tre typer av icke-fysiska fiskledare och deras effektivitet i att leda odlade smolt av Atlantlax (Salmo salar L.) till en önskad passage. Målet med denna studie var att undersöka om det var möjligt att leda odlade laxsmolt till en önskad passage med hjälp av bubblor, strobeljus eller en kombination av bubblor och strobeljus. Med relativt enkla medel och låg kostnad konstruerades fiskledare som bestod av en perforerad slang driven av en luftkompressor samt en ljusramp med fyra LED-lampor vilka blinkade simultant med 480 bpm. Fem replikat genomfördes för vardera behandling, bubblor, strobeljus och bubblor/strobeljus, samt sex replikat i kontrollen. Under en timmes behandling fick tio laxsmolt, märkta med PIT-tag, passera en av två antenner, varav den ena var utrustad med en fiskledare, under vandring i nedströms riktning i ett strömakvarium. Denna studie visade att fiskledare av samtliga tre metoder ledde smolt till en önskad passage under behandlingens första femton minuter. Vidare visade fiskledaren bestående av bubblor en fortsatt ledande förmåga över hela behandlingsperioden (60 minuter), medan fiskledarna av strobeljus- och bubbel/strobeljus inte visade en sådan effekt.
Passages by fish through hydropower plants are associated with high mortality. In order to reduce the impact of hydropower plants on fish stocks, a variety of fish guiding systems have evolved. In this laboratory study, three types of non-physical fish guiding systems were evaluated by their efficiency in leading cultivated smolt of Atlantic salmon (Salmo salar L.) to a desired passage. This study aimed to answer if it is possible to guide salmon smolt to a desired safe passage by using bubbles, strobe light or a combination of bubbles and strobe light. With relatively simple means and low cost, fish-guides were constructed consisting of a perforated tube driven by an air compressor and a light ramp with four LED lights, which simultaneously flashed at 480 bpm. Five replicates were performed for each treatment; bubbles, strobe light and bubbles / strobe light, as well as six replicates for the controls. During one hour of treatment, ten salmon smolt, marked with PIT tag, could pass one of two antennas, where one had a fish-guide in front of the antenna, while migrating downstream in a stream aquarium. This study showed that fish-guides of all three methods led smolt to a desired passage during the first fifteen minutes of treatment. Furthermore, the bubble method showed a continuous guiding capacity throughout the treatment period (60 minutes), while the strobe light and bubble/strobe light did not show such an effect.
Estilos ABNT, Harvard, Vancouver, APA, etc.
22

Bartl, Jan. "Příprava realizace multifunkčniho objektu Technologického parku v Brně". Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-409915.

Texto completo da fonte
Resumo:
The theme of my diploma thesis is a preparation of realization of administrative building, The Czech Technological park Brno. Thesis contains a technical report of the technological project, a mechanical assembly, a technological specification of monolithic structure contains a included inspection and test plan and a calculation of the formwork time. It also includes the project of construction zone solution, a time schedule, a time and financial plan, an itemized budget and bill of quantities, a calculation of buildings according to THU, a transport routes. Part of the thesis are also selected a LEED certification credits and safety and a health protection during work plan.
Estilos ABNT, Harvard, Vancouver, APA, etc.
23

Dvořák, Radim. "Zvýšení efektivity montážního pracoviště". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318827.

Texto completo da fonte
Resumo:
This diploma thesis deals with increasing the efficiency of the assembly workplace (production line). Thesis gradually discusses with lean production, their basic methods and the EURO VI emission standard, which is closely related to the produced product. In the main part, an analysis of the current state is performed with the help of the above-mentioned methods and a proposal of solutions to ensure efficiency. On the base of these findings, the automation of the test station is proposed, including a 3D model, drawing documentation, phases of implementation and real cost calculations with a final assessment of efficiency, return of investments and risk analysis. The second elaborated complementary variant deals with the ergonomics of the production line and includes a 3D model of newly designed tables, real calculations and final economic evaluation.
Estilos ABNT, Harvard, Vancouver, APA, etc.
24

Hořínková, Dita. "Stavebně technologický projekt výstavby komplexu RD SLAVKOV - Pod Zlatou horou". Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-409928.

Texto completo da fonte
Resumo:
The subject of the diploma thesis is the solution of chosen parts of the construction technology project of the 1st phase of the construction „Komplex RD Slavkov, Pod Zlatou horou“. These are 4 semi-detached houses, overall 8 family houses. The work deals with technological regulations for the superstructure including roof, study of the realization of the construction technology project, design of the main construction machines and mechanisms and control and test plan. For the whole construction is elaborated time and financial plan in two variants, namely the gradual and current method of construction, and a detailed schedule for one semi-detached house. The technical report of the building site equipment is completed with the drawings, itemized budget of the building part of the house, noise study and specialization focused on the photovoltaic system, with an alternative solution to use solar collectors. The thesis also includes a case study of construction methods focused on the gradual and current method of construction.
Estilos ABNT, Harvard, Vancouver, APA, etc.
25

Průcha, Aleš. "Příprava realizace dostavby klinické hematologie FN Brno". Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-409941.

Texto completo da fonte
Resumo:
The aim of this diploma thesis is a solution of the extension of clinical hematology of the Faculty Hospital Brno. The thesis deals with the technological regulation for steel construction, coupled ceiling concrete slab with other topics including an inspection-check plan, a time schedule for carcass, time and financial schedule for structures and an item budget. In addition, this work includes the coordination site-layout of the construction with wider transport relations, mechanical assembly, the principles of the organization of site equipment and occupational safety and health risks. Finally this thesis contains several assessments for cranes, scheme of principles of fixing steel columns into structure, scheme of laying building envelope, LEED, site equipment financial assessment.
Estilos ABNT, Harvard, Vancouver, APA, etc.
26

Hoffmann, Stephen Reed. "Strong binding of copper, zinc, and lead to colloids and natural organic matter in rivers". 2002. http://www.library.wisc.edu/databases/connect/dissertations.html.

Texto completo da fonte
Estilos ABNT, Harvard, Vancouver, APA, etc.
27

Milkiewicz, Olga. "EasyJet Plc: lean, strong and determined". Master's thesis, 2015. http://hdl.handle.net/10362/15415.

Texto completo da fonte
Estilos ABNT, Harvard, Vancouver, APA, etc.
28

Yeh, Chung-lin, e 葉重麟. "STUDY OF LED CURRENT BALANCE FOR PARALLEL STRING CONFIGURATION". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/36754294906447267668.

Texto completo da fonte
Resumo:
碩士
大同大學
電機工程學系(所)
100
In this thesis, a simply current balance method of the light emitting diodes (LEDs) string via the connection of passive components is proposed to achieve current balance and current sharing between two serial LEDs strings. In recent years, the researches of LED are proposed due to the wide applications of LED in the lightings, backlight of monitor, street lights, vehicle lamps, and so on. However, a single LEDs string does not enough to provide illumination, and therefore, the multiple LEDs strings are developed. The most important issue by using the multiple LEDs strings is the unbalanced current of each LEDs string. It causes the uneven brightness as the unbalance of every LEDs string serial current occurs. Therefore, the passive component current balance method is proposed to improve the phenomenon of the unbalanced current of each LEDs string which is caused by the different forward voltages of LEDs. The advantages of the proposed method include fewer components, low complexity, cost saving, and easy to be implemented. Finally, the simulations and experimental results verify the effectiveness of the proposed method.
Estilos ABNT, Harvard, Vancouver, APA, etc.
29

Syu, Jhih-yao, e 許智堯. "Output-Cascoded Single-Stage Two-String LED Street Lamp Driver". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/81142462903183344788.

Texto completo da fonte
Resumo:
碩士
國立臺灣科技大學
電子工程系
101
This thesis studies a modular power supply for driving an LED streetlamp with multiple strings of LEDs. A 130-W topology is proposed and verified based on the single-stage flyback converter. Operation principles of the topology are discussed and design guidelines are provided. A 100-W constant-voltage single-stage AC-DC flyback converter, and two 15-W constant-current DC-DC counterparts are implemented. The presented modular LED streetlamp driver is thus fulfilled by combining these three converters with parallel-connected inputs and cascoded outputs. An input current shaping circiut is added to raise the power factor.
Estilos ABNT, Harvard, Vancouver, APA, etc.
30

Wang, Lih-Chiann, e 王儷蒨. "Induction of DNA strand break and 8-OHdG formation by lead acetate in vitro". Thesis, 1997. http://ndltd.ncl.edu.tw/handle/75978766146279957088.

Texto completo da fonte
Resumo:
碩士
國立清華大學
生命科學系
85
The mechanism of DNA damage induced by lead was explored in this study. Lead acetate could induce DNA strand breakage in Hepes buffer, pH 6.8, in a dose- and time-dependent manner as determined using the plasmid relaxationassay. When compared with lead, zinc acetate did not significantly induced DNA breakage. Singlet oxygen scavengers NaN3 and 2,2,6,6-tetramethyl-4- piperidone (TEMP) markedly inhibited lead-induced DNA breakage. D2O, low dosesof glutathione and 2-mercaptoethanol (singlet oxygen enhancers) could enhancelead-induced DNA breakage. Electron paramagnetic resonance (EPR) spectra showedthat singlet oxygen but not hydroxyl radical signal was detected in lead solution. Furthermore, lead-induced DNA breakage was markedly enhanced by ascorbate in a dose-dependent manner. Catalase, NaN3, and EDTA significantlyinhibited lead/ascorbate-induced DNA breakage, indicating the participation ofH2O2, singlet oxygen, and lead in this reaction. This result suggests that leadpromotes ascorbate autooxidation, enhances the reduction of O2 to H2O2 simultaneously, and catalyzes Haber-Weiss reaction. Additionally, lead-inducedDNA breakage was markedly enganced by H2O2, and this induction was inhibited byNaN3, TEMP, glutathione, BSA, EDTA, and catalase. The results have indicated that singlet oxygen, lead, and H2O2 are all involved in the reaction system.Lead could cause a small amount of 8-hydrodeoxyguanosine (8-OHdG) formation in calf thymus DNA, and dose-dependent induced the formation of this adduct in the presence of H2O2 using HPLC-UV-ECDmethod. Singlet oxygen scavengers were more effective than hydroxyl radical scavengers in protection from lead/H2O2-induced 8-OHdG adducts. EPR spectrashowed that singlet oxygen signal was additively induced by lead/H2O2, whereaslead inhibited the hydroxylll radical signal induced by H2O2 in a prolongedincubation time. Taken together, singlet oxygen is an important factor for leadinduced DNA breakage. The results were well correlated to that the observation of lead -induced specific mutational spectrum may due to singlet oxygen and 8-OHdG (Yang et al., Mol Carcinogenesis: 17:181-191, 1996). This study showed that lead could function as transition metao ions Cu2+ and Fe3+ to catalyzefree radical generation.
Estilos ABNT, Harvard, Vancouver, APA, etc.
31

Wu, Chu-Yen, e 吳居諺. "Design and Implementation of a Current Balance Driving System for Multi-string LED Backlight". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/sexzmf.

Texto completo da fonte
Resumo:
碩士
國立臺北科技大學
電力電子產業研發碩士專班
102
This thesis develops a current balance driver system for multi-string LED backligh. The first stage uses boost power factor correction converter operating in critical conduction mode in which power factor correction and soft switching are introduced to achieve high power factor and high efficiency. The second stage combines a half-bridge resonant converter and a boost converter. The current balance driving system can be implemented as the driving multi-string LED backlight. The half-bridge resonant converter has zero voltage switching on primary side power switches and zero current switching on the secondary side rectifier diodes. The secondary side windings of the transformer are connected to each of the multiple LED strings. The boost LED driver feedback control is used to achieve current balance for multi-string LED backlight. This thesis features power factor correction, LED current balance, a more simplified circuit topology. Finally, the design specifications for three string LED backlight include output voltage 210V, output current 260mA and AC input voltage 90V~264V. Experimental results verify that this system can meet the LED backlight driver design requirements. Power supply has efficiency up to 86%, power factor up to 0.97.
Estilos ABNT, Harvard, Vancouver, APA, etc.
32

Chen, Yu-Wei, e 陳佑瑋. "Design of an AC-powered LED string adapted to the variation of the voltage applied". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/14108491769480982249.

Texto completo da fonte
Resumo:
碩士
崑山科技大學
光電工程研究所
105
This paper proposes a digital method to eliminate the conduction angle to turn on a LED string with an AC power. AC LED uses AC current directly without the need to convert it to DC current. However, AC LED flares with the vibration of the AC voltage, which might introduce an unsteady lighting effect to human eyes because of its conduction angle. Here, the proposed digital method is simple to implement and able to eliminate the conduction angle almost. In other words, the LED string driven by an AC power can light almost all the time just with its intensity following the variation of the AC voltage. In the end, the efforts having to be paid more than those using AC LED is discussed. The method proposed in this paper does help to reduce the conduction angle of the LED grain array, from the measurement results of the conduction angle is almost zero. In other words, the LED grain array can be turned on almost at any time, except that the strength of the light source exhibits a positive correlation with the magnitude of the voltage across the LED grain array. DC power supply directly to drive 38 LED crystal, according to LED (NSPW500CS, Nichia) data brochure, the need for output power 4.56W or more DC power supply; and in this article using the implementation of the circuit, the demand for DC power supply switch circuit (S1 to S14) and the operation of the microcontroller, the maximum required power consumption is about 0.536W. There is a significant difference in the volume of the transformer used inside the DC power supply, which can even use the transformer without the need for DC power supply. Although the circuit mentioned in this article is not as good as the AC LED streamlining, it can greatly improve the AC LED conduction angle problem, and the increase in circuit cost and volume is still far less than the original use of DC power supply driver LED grain way.
Estilos ABNT, Harvard, Vancouver, APA, etc.
33

ZENG, GUAN-CI, e 曾冠綺. "Study and Implementation of a High-Performance Driver for Multi-Parallel LED Strings". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/61217946129115913068.

Texto completo da fonte
Resumo:
碩士
國立臺灣科技大學
電子工程系
96
A high performance light-emitting diodes (LED) driver is proposed in this paper. The circuit of this driver consists of a voltage pre-regulator and multiple linear current regulators. We propose a kind of control method to keep the linear current regulator with highest performance. This method makes the surplus voltage of the linear current regulator close to zero, and drive the multi-parallel LED’s brightness the same. The tradition control method of the voltage pre-regulator is using the across voltage between drain gate and source gate of the linear current regulator’s MOSFET. The resistance between MOSFET’s drain and source (RDS(on)) changes with temperature. That is the problem why the voltage pre-regulator can’t operate in the best performance automatically. This paper proposed a control method with voltage pre-regulator using MOSFET’s gate voltage. This method has following advantages: simple design parameters, independent of temperature, and the ability to control the voltage pre-regulator immediately when the load changed. This paper analyzes the circuit in detail, and practices to prove it feasibility. The experiment results show that this method can increase the performance in the multi-parallel LED application effectively.
Estilos ABNT, Harvard, Vancouver, APA, etc.
34

Lin, Cheng-hsien, e 林政賢. "Study and Implementation of a Dimmable LED Driver with Multi-string Current Balance and Low Switch Voltage Stress". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/05305942816712179259.

Texto completo da fonte
Resumo:
碩士
國立臺灣科技大學
電子工程系
101
This thesis studies and implements a dimmable LED Driver with multi-channel current balance and low switch voltage stress. The front stage is a single-stage flyback power factor corrector (PFC) converter which features high conversion efficiency, high power factor (PF) and simple topology. It supplies the main output current and a constant output voltage to the LED module. The post-stage is a buck converter which outputs an accurate current to the LED module and fulfills the multi-channel current balance and dimming functions. The buck converter is of a floating ground configuration which features small volume and high conversion efficiency. The proposed LED driver is composed of a flyback PFC cascaded by a floating ground buck converter, resembling a voltage source in series with a current source. At most three LED strings can be driven. Within the designed voltage range, the number of LEDs in one string can be adjusted and various types of lamps can be adopted. The proposed dimmable driver with current balance can lower the switch voltage stress. Therefore, the power loss and circuit cost can be reduced.
Estilos ABNT, Harvard, Vancouver, APA, etc.
Oferecemos descontos em todos os planos premium para autores cujas obras estão incluídas em seleções literárias temáticas. Contate-nos para obter um código promocional único!

Vá para a bibliografia