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1

(Firm), Bantam Books, e Copyright Paperback Collection (Library of Congress), eds. Stroke by stroke. New York: Bantam Books, 1993.

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2

Lee, Seung-Hoon, ed. Stroke Revisited: Hemorrhagic Stroke. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-1427-7.

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3

Warlow, Charles. Stroke. Rickmansworth, Herts: Barbara Woodhouse, 1987.

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4

Warlow, C., J. van Gijn, M. Dennis, J. Wardlaw, J. Bamford, G. Hankey, P. Sandercock et al., eds. Stroke. Oxford, UK: Blackwell Publishing Ltd, 2008. http://dx.doi.org/10.1002/9780470696361.

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5

Steiner, Thorsten, Werner Hacke e Daniel F. Hanley, eds. Stroke. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-60264-1.

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6

Barrett, Kevin M., e James F. Meschia, eds. Stroke. Oxford: John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118560730.

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7

J, Wityk Robert, e Llinas Rafael H, eds. Stroke. Philadelphia: American College of Physicians, 2007.

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8

1949-, Fisher Mark, ed. Stroke. Amsterdam: Elsevier, 2008.

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9

1949-, Fisher Mark, ed. Stroke. Edinburgh: Elsevier, 2009.

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10

R, Caplan Louis, ed. Stroke. New York: Oxford University Press, 2011.

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11

Caplan, Louis R. Stroke. New York: Demos, 2006.

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12

Yatsu, Frank M. Stroke. London: Arnold, 1992.

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13

Aging, National Institute on, ed. Stroke. [Bethesda, Md.]: National Institute on Aging, U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 2004.

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14

Executive, NHS, ed. Stroke. [London]: Department of Health, 1995.

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15

Lindley, Richard Iain. Stroke. Oxford: Oxford University Press, 2008.

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16

Association of the British Pharmaceutical Industry. Office of Health Economics. Stroke. London: Office of Health Economics, 1988.

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17

Dale, Sarah. Stroke. London: Office of Health Economics, 1988.

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18

A, Banks Moira, ed. Stroke. Edinburgh: Churchill Livingstone, 1986.

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19

Lindley, Richard Iain. Stroke. Oxford: Oxford University Press, 2008.

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20

Hennerici, M. Stroke. London: Mosby, 2004.

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21

B, Morgenstern Lewis, ed. Stroke. Philadelphia: W.B. Saunders, 2000.

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22

A, Banks Moira, ed. Stroke. Edinburgh: Churchill Livingstone, 1986.

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23

Great Britain. Department of Health. e NHS Executive, eds. Stroke. [U.K.]: NHS Executive, 1994.

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24

Hankey, Graeme J. Stroke. Edinburgh: Churchill Livingstone, 2002.

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25

1923-, McDowell Fletcher H., e Easton J. Donald, eds. Stroke. Philadelphia, PA: Lea & Febiger, 1987.

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26

Lee, Seung-Hoon, e Min Kyoung Kang, eds. Stroke Revisited: Dyslipidemia in Stroke. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-3923-4.

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27

Lee, Seung-Hoon, e Dong-Wan Kang, eds. Stroke Revisited: Diabetes in Stroke. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-5123-6.

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28

Lee, Seung-Hoon, ed. Stroke Revisited: Pathophysiology of Stroke. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-10-1430-7.

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29

Bennett, Jamie. Stroke by Stroke. Independently Published, 2018.

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30

(Translator), Richard Sieburth, ed. Stroke by Stroke. Absolute Classics, 2006.

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31

Stroke Hope Stroke Awareness: Stroke awareness. CreateSpace Independent Publishing Platform, 2017.

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32

Calligraphy - Stroke by Stroke. Bounty Books, 1999.

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33

Lee, Seung-Hoon. Stroke Revisited: Hemorrhagic Stroke. Springer London, Limited, 2018.

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34

Lee, Seung-Hoon. Stroke Revisited: Hemorrhagic Stroke. Springer, 2019.

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35

Lee, Seung-Hoon. Stroke Revisited: Hemorrhagic Stroke. Springer, 2018.

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36

Calligraphy Stroke-by-stroke. Headline Book Publishing, 1995.

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37

Callilgrqphy, Stroke-by-Stroke. Quantum Publishing, 2006.

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38

Hennerici, Michael G., Kristina Szabo, Rolf Kern e Johannes Binder. Stroke. Oxford University Press, 2012.

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39

Fadeyev, P. A. Stroke. Book on Demand Ltd., 2018.

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40

Haunton, Victoria, Aung Sett, Amit Mistri e Martin Fotherby. Stroke. Editado por Patrick Davey e David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0227.

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The World Health Organization defines stroke as ‘a clinical syndrome consisting of rapidly developing clinical signs of focal (at times global) disturbance of cerebral function lasting greater than 24 hours (or leading to death) with no apparent cause other than that of vascular origin’. Transient ischaemic attack (TIA) is defined as a rapid presentation of neurological deficit with complete recovery within 24 hours of the onset of symptoms. However, the 24-hour cut-off is arbitrary, has no biological basis, and is of limited use clinically. A shorter duration is now regarded as more appropriate, although it has yet to be universally accepted. In clinical practice, stroke and TIA are best thought of as comprising a continuum, as they have similar pathological mechanisms, etiologies, and management strategies. While subarachnoid haemorrhage is a type of stroke based on the above definition, it is not covered in this chapter, as its pathophysiology, clinical manifestations, and management are distinct from those for ischaemic stroke and haemorrhagic stroke.
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41

Bowker, Lesley K., James D. Price, Ku Shah e Sarah C. Smith. Stroke. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198738381.003.0008.

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This chapter provides information on definition and classification, predisposing factors, acute assessment, investigations, acute management, stroke units, thrombolysis, intra-arterial therapies, ongoing management, complications, longer-term issues, and transient ischaemic attack clinics.
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42

Stroke. Elsevier, 2022. http://dx.doi.org/10.1016/c2018-0-02267-7.

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43

Dehkharghani, Seena, ed. Stroke. Exon Publications, 2021. http://dx.doi.org/10.36255/exonpublications.stroke.2021.

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44

Stroke. Elsevier, 2011. http://dx.doi.org/10.1016/c2009-0-40556-7.

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45

Stroke. Elsevier, 2004. http://dx.doi.org/10.1016/b0-443-06600-0/x5001-9.

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46

Stroke. Elsevier, 2016. http://dx.doi.org/10.1016/c2012-0-02756-1.

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47

Stroke. Elsevier, 2008. http://dx.doi.org/10.1016/s0072-9752(08)x0011-9.

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48

Leys, Didier, Charlotte Cordonnier e Valeria Caso. Stroke. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0067.

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Stroke is a major public health issue. Many are treatable in the acute stage, provided patients are admitted soon enough. The overall incidence of stroke in Western countries is approximately 2400 per year per million inhabitants, and 80% are due to cerebral ischaemia. The prevalence is approximately 12 000 per million inhabitants. Stroke is associated with increased long-term mortality, handicap, cognitive and behavioural impairments, recurrence, and an increased risk of other types of vascular events. It is of major interest to take the heterogeneity of stroke into account, because of differences in the acute management, secondary prevention, and outcomes, according to the subtype and cause of stroke. In all types of stroke, early epileptic seizures, delirium, increased intracranial pressure, and non-specific complications are frequent. In ischaemic strokes, specific complications, such as malignant infarcts, spontaneous haemorrhagic transformation, early recurrence, and a new ischaemic event in another vascular territory, are frequent. In haemorrhagic strokes, the major complication is the subsequent increased volume of bleeding. There is strong evidence that stroke patients should be treated in dedicated stroke units; each time 24 patients are treated in a stroke unit, instead of a conventional ward, one death and one dependence are prevented. This effect does not depend on age, severity, and the stroke subtype. For this reason, stroke unit care is the cornerstone of the treatment of stroke, aiming at the detection and management of life-threatening emergencies, stabilization of most physiological parameters, and prevention of early complications. In ischaemic strokes, besides this general management, specific therapies include intravenous recombinant tissue plasminogen activator, given as soon as possible and before 4.5 hours, otherwise aspirin 300 mg, immediately or after 24 hours in case of thrombolysis, and, in a few patients, decompressive surgery. In intracerebral haemorrhages, blood pressure lowering and haemostatic therapy, when needed, are the two targets, but surgery does not seem effective to reduce death and disability.
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49

Leys, Didier, Charlotte Cordonnier e Valeria Caso. Stroke. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199687039.003.0067_update_001.

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Stroke is a major public health issue. Many are treatable in the acute stage, provided patients are admitted soon enough. The overall incidence of stroke in Western countries is approximately 2400 per year per million inhabitants, and 80% are due to cerebral ischaemia. The prevalence is approximately 12 000 per million inhabitants. Stroke is associated with increased long-term mortality, handicap, cognitive and behavioural impairments, recurrence, and an increased risk of other types of vascular events. It is of major interest to take the heterogeneity of stroke into account, because of differences in the acute management, secondary prevention, and outcomes, according to the subtype and cause of stroke. In all types of stroke, early epileptic seizures, delirium, increased intracranial pressure, and non-specific complications are frequent. In ischaemic strokes, specific complications, such as malignant infarcts, spontaneous haemorrhagic transformation, early recurrence, and a new ischaemic event in another vascular territory, are frequent. In haemorrhagic strokes, the major complication is the subsequent increased volume of bleeding. There is strong evidence that stroke patients should be treated in dedicated stroke units; each time 24 patients are treated in a stroke unit, instead of a conventional ward, one death and one dependence are prevented. This effect does not depend on age, severity, and the stroke subtype. For this reason, stroke unit care is the cornerstone of the treatment of stroke, aiming at the detection and management of life-threatening emergencies, stabilization of most physiological parameters, and prevention of early complications. In ischaemic strokes, besides this general management, specific therapies include intravenous recombinant tissue plasminogen activator, given as soon as possible and before 4.5 hours, otherwise aspirin 300 mg, immediately or after 24 hours in case of thrombolysis, and, in a few patients, decompressive surgery. In intracerebral haemorrhages, blood pressure lowering and haemostatic therapy, when needed, are the two targets, but surgery does not seem effective to reduce death and disability.
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50

Leys, Didier, Charlotte Cordonnier e Valeria Caso. Stroke. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199687039.003.0067_update_002.

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Stroke is a major public health issue. Many are treatable in the acute stage, provided patients are admitted soon enough. The overall incidence of stroke in Western countries is approximately 2400 per year per million inhabitants, and 80% are due to cerebral ischaemia. The prevalence is approximately 12 000 per million inhabitants. Stroke is associated with increased long-term mortality, handicap, cognitive and behavioural impairments, recurrence, and an increased risk of other types of vascular events. It is of major interest to take the heterogeneity of stroke into account, because of differences in the acute management, secondary prevention, and outcomes, according to the subtype and cause of stroke. In all types of stroke, early epileptic seizures, delirium, increased intracranial pressure, and non-specific complications are frequent. In ischaemic strokes, specific complications, such as malignant infarcts, spontaneous haemorrhagic transformation, early recurrence, and a new ischaemic event in another vascular territory, are frequent. In haemorrhagic strokes, the major complication is the subsequent increased volume of bleeding. There is strong evidence that stroke patients should be treated in dedicated stroke units; each time 24 patients are treated in a stroke unit, instead of a conventional ward, one death and one dependence are prevented. This effect does not depend on age, severity, and the stroke subtype. For this reason, stroke unit care is the cornerstone of the treatment of stroke, aiming at the detection and management of life-threatening emergencies, stabilization of most physiological parameters, and prevention of early complications. In ischaemic strokes, besides this general management, specific therapies include intravenous recombinant tissue plasminogen activator, given as soon as possible and before 4.5 hours, mechanical thrombectomy in case of proximal occlusion (middle cerebral artery, intracranial internal carotid artery, basilar artery), on top of thrombolysis in the absence of contraindication or alone otherwise, aspirin 300 mg, immediately or after 24 hours in case of thrombolysis, and, in a few patients, decompressive surgery. In intracerebral haemorrhages, blood pressure lowering and haemostatic therapy, when needed, are the two targets, while surgery does not seem effective to reduce death and disability.
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