Literatura científica selecionada sobre o tema "Spectroscopie RMN in vivo"
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Artigos de revistas sobre o assunto "Spectroscopie RMN in vivo"
Bloch, G. "Etude par spectroscopie RMN in vivo du transport du glucose dans le muscle humain." médecine/sciences 14, n.º 10 (1998): 1083. http://dx.doi.org/10.4267/10608/914.
Texto completo da fonteRoby, C., R. Bligny e R. Douce. "Exploration de la cellule végétale par spectroscopie RMN". Journal de Chimie Physique 89 (1992): 253–70. http://dx.doi.org/10.1051/jcp/1992890253.
Texto completo da fonteImperiale, A. "La spectroscopie RMN dans le diagnostic du phéochromocytome". Annales d'Endocrinologie 78, n.º 4 (setembro de 2017): 203. http://dx.doi.org/10.1016/j.ando.2017.07.748.
Texto completo da fonteDuchemann, B., M. Triba, D. Guez, H. Nunes, D. Valeyre, J. F. Bernaudin e L. Le Moyec. "Étude par spectroscopie RMN du métabolisme salivaire dans la sarcoïdose". Revue des Maladies Respiratoires 29 (janeiro de 2012): A96—A97. http://dx.doi.org/10.1016/j.rmr.2011.10.313.
Texto completo da fontePayen, J.-F., G. Francony, B. Fauvage e J.-F. Le Bas. "Apport de la spectroscopie RMN à l'évaluation du traumatisme crânien". Annales Françaises d'Anesthésie et de Réanimation 24, n.º 5 (maio de 2005): 522–27. http://dx.doi.org/10.1016/j.annfar.2005.03.005.
Texto completo da fonteLe Botlan, D. J. "Etude par spectroscopie rmn 13C de la solution aqueuse formaldehyde-methanol". Journal de Chimie Physique 84 (1987): 115–23. http://dx.doi.org/10.1051/jcp/1987840115.
Texto completo da fonteLagarde, D., M. Pérès, B. Barrère, CY Guézennec e C. Piérard. "Modafinil et aminoacides neurotransmetteurs cérébraux: étude par spectroscopie RMN et microdialyse". Neurophysiologie Clinique/Clinical Neurophysiology 26, n.º 6 (janeiro de 1996): 435. http://dx.doi.org/10.1016/s0987-7053(97)89184-8.
Texto completo da fonteGariod, L., A. Favre-Juvin, V. Novel, H. Reutenauer, H. Majean e A. Rossi. "Évaluation du profil énergétique des judokas par spectroscopie RMN du P31". Science & Sports 10, n.º 4 (janeiro de 1995): 201–7. http://dx.doi.org/10.1016/0765-1597(96)89370-1.
Texto completo da fonteKozak-Reiss, G. "Nouvelles explorations de la fonction musculaire : spectroscopie RMN. Application à l'hyperthermie maligne". Annales Françaises d'Anesthésie et de Réanimation 8, n.º 5 (janeiro de 1989): 400–405. http://dx.doi.org/10.1016/s0750-7658(89)80005-x.
Texto completo da fonteTouré, Assane, Cheikh Abdoul Khadir Diop, Libasse Diop e Bernard Mahieu. "Synthèse et étude par spectroscopie Mössbauer, infrarouge et RMN de nouveaux complexes carboxylato organostanniques". Comptes Rendus Chimie 10, n.º 6 (junho de 2007): 493–97. http://dx.doi.org/10.1016/j.crci.2006.06.014.
Texto completo da fonteTeses / dissertações sobre o assunto "Spectroscopie RMN in vivo"
Blondet, Pascal. "Spectroscopie RMN localisée haute résolution du proton "in vivo"". Grenoble 1, 1988. http://www.theses.fr/1988GRE10002.
Texto completo da fonteBlondet, Pascal. "Spectroscopie RMN localisée haute résolution du proton "in vivo"". Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37612005s.
Texto completo da fonteDesal, Hubert-Armand. "Développements méthodologiques en spectroscopie RMN in vivo pour l'étude des tumeurs cérébrales". Nantes, 2008. https://archive.bu.univ-nantes.fr/pollux/show/show?id=5ae4877d-3eb7-4e08-8246-57b355a34c3d.
Texto completo da fonteThe first step of our work was the evaluation of the reproducibility and the reliability of different methodological development of localized spectroscopy sequences (PRESS & STEAM) and parameters (TE &TR) on normal volunteers. We have proposed a “home-made” post-processing protocol, which is easily and directly available on the MRI unit. The second step was the application of this protocol to patients with glial brain tumors. We were now able to assess the better methodology using Principal Components Analysis (PCA). PCA has showed to be simple and efficient to visually determine the aggressiveness of the tumor in a graph. Two further preliminary studies were conducted, one evaluating a new strategy to determine the best echo time based on simulated intensity and PCA, the second considering a new and original method (ERETIC) for absolute quantification on a commercial MR unit
Malaquin, Sophie. "Spectroscopie RMN in vivo pondérée en diffusion pour l'étude de la compartimentation du lactate cérébral". Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPAST196.
Texto completo da fonteIn the gray matter of the brain, lactate is a metabolite known for its role in brain function and metabolism. The main proposed mechanism, the astrocyte-to-neuron shuttle, plays a crucial role in brain metabolism, and disruptions are likely involved in Alzheimer's disease. In the absence of non-invasive tools for measuring lactate compartmentalization, this mechanism remains a subject of controversy. The idea behind this thesis is that diffusion-weighted NMR spectroscopy could enable the non-invasive measurement of lactate compartmentalization: it is possible to obtain information about diffusion properties induced by different cellular microstructures, and since lactate is present in astrocytes, neurons, and the extracellular space, it would suffice to measure its diffusion properties and compare them to the specific signatures of intraneuronal, intra-astrocytic, and extracellular diffusions to obtain information about its compartmentalization. These measurements were conducted in murine models where a change in compartmentalization was suspected, specifically an astrocytic reactivity model with hypertrophied astrocytes and a pathological model of Alzheimer's disease. These results were compared to reference optical and electrochemical measurements that allow for the 'direct' measurement of lactate in different compartments
Izquierdo, Marguerite. "Caractérisation spectrale en spectroscopie RMN in vivo : contribution au développement de méthodes physiques d'investigation". Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE10153.
Texto completo da fonteLigneul, Clémence. "Développements méthodologiques en spectroscopie RMN in vivo pondérée en diffusion pour l'exploration du milieu intracellulaire dans le cerveau de rongeur". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS244/document.
Texto completo da fonteIn vivo diffusion-weighted NMR spectroscopy is sensitive to the motion of cerebral metabolites (glutamate, creatine, choline, NAA, myo-inositol, taurine…), allowing the measurement of their apparent diffusion coefficient (ADC). Since these metabolites are purely intracellular, their ADC only depends on the intracellular medium, in particular cytosol viscosity, density of intracellular structures, and the shape and size of cells. In general, metabolite ADC is measured for a single diffusion time Td, equal to a few dozens milliseconds, leaving them time to explore a few micrometers and to interact repeatedly with intracellular structures. Their ADC then potentially depends on all intracellular parameters mentioned above, in a poorly defined way. This thesis presents new spectroscopy methods in the rodent brain to measure ADC over an unprecedented range of Td, from approximately 0.2 milliseconds up to 2 seconds. A first set of measurements has been modeled to extract key morphological brain cell parameters. The sensitivity of these methods to morphological changes in brain cell morphology has first been studied on mice injected with CNTF (ciliary neurotrophic factor), that causes a strong hypertrophy of a specific cell type, astrocytes. Diffusion properties of some metabolites are indeed sensitive to this massive cell morphological change. The last part presents the application to a transgenic mouse model of Huntington’s disease
Baxan, Nicoleta. "Mise en oeuvre de microantennes RMN en perspective d'étude in vivo de métabolites par spectroscopie". Lyon 1, 2008. http://www.theses.fr/2008LYO10001.
Texto completo da fonteConsidering the need to explore by MR spectroscopy small quantities of tissue, it is possible to create probes with a working volume compatible with such limitations. This work is centred on the research of efficient solutions to create implantable microsensors by microelectronic techniques especially for in vivo application in preclinical purposes. The first chapter of the theses is an overview on the MR microcoil utilisation on the international context. In the second chapter we describe the microcoil development, its spatial sensitivity estimated by simulation and further correlated by MRI enabling us to estimate the active volume close to 2 μl when the microcoil is used as receiver only. The third chapter is dedicated to the evaluation of microcoil performances in tremes of limit of detection. The presented results made possible to validate the use of microcoils associated with MR spectroscopy sequences based on monovoxel techniques and to measure the sensivity of the technique. The last chapter describes a possible pathway to the microcoil implantation on living tissues and also identifying the difficulties of this approach. The example presented here covers the rat brain explorarion. This study presents the concept and the performances of a new generation of microcoils making possible to validate their performances in MR spectroscopy and largely opening innovative possibilities of highly spatial resolved explorations
Tiret, Brice. "Développements méthodologiques en RMN des noyaux X pour l’étude in vivo du métabolisme cérébral pendant la neurodégénérescence". Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS221.
Texto completo da fonteThe aim of this thesis was to develop at MIRCen new capabilities to observe two key aspects of energy metabolism in rodent brains using X nuclei NMR spectroscopy: glucose consumption with 13C spectroscopy and adenosine triphosphate (ATP) synthesis with 31P measurements. These developments will be used to both expand general understanding of brain metabolism in healthy subjects but also provide technical tools to search for biomarkers in translational projects of drug development applied to neurodegenerative diseases. This work was done at very high field (11.7T) where signal to noise could be maximized. In the first part, we present the optimization of saturation transfer sequence to measure ATP synthesis rate as well as phosphocreatine (PCr) synthesis rate. With ISIS module, the signal was localized to a voxel containing only the brain, eliminating outside source of signal. With the higher spectral resolution offered by high fields, a second, extracellular pool of Pi was characterized which could prevent possible biases in flux quantification of ATP synthesis. This sequence was also applied to measure metabolic adaptation of BACHD rat models (models of Huntington’s disease, HD) where it was found that the 10% increase in PCr concentration could palliate the ATP synthase activity that is halved in this model. In the second part, we present how deeper analysis of 13C data using automatic differential equation writing script was used to better understand the bicompartmental model of glucose degradation to glutamate and glutamine, which accounts for TCA cycle in neurons and astrocytes. Two major corrections were made to the traditional model, to fit mid- and long-term unexplained dynamics. Looking at glutamate and glutamine isotopomer labeling dynamics, the necessity of adding a vesicular glutamate temporal buffer was made evident. The distinction between astrocytic and neuronal pyruvate dilution also showed that astrocytes use up to 6 times more pyruvate than neurons showing intricate metabolic coupling between the two cell types. These results have then been tested in vivo after optimization of the ISIS-DEPT sequence to observe 13C labeling in the rat brain. Finally, experiments combining 31P and 13C spectroscopy were performed on rats chronically intoxicated with 3-NP, a toxin inhibiting TCA cycle which is used as a model of HD
Kienlin, Markus von. "Instrumentation et méthodologie en spectroscopie RMN in vivo suppression de l'eau, édition de spectre et localisation spatiale /". Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37619193v.
Texto completo da fonteHERIGAULT, GWENAEL. "Spectroscopie rmn du proton in vivo a 1 ou 2 dimensions frequentielles. Application au cerveau de rat tumoral". Université Joseph Fourier (Grenoble), 2000. http://www.theses.fr/2000GRE10157.
Texto completo da fonteLivros sobre o assunto "Spectroscopie RMN in vivo"
Graaf, Robin A. De. In vivo NMR spectroscopy: Principles and techniques. Chichester: Wiley, 1998.
Encontre o texto completo da fonteGraaf, Robin A. De. In vivo NMR spectroscopy: Principles and techniques. 2a ed. Chichester, West Sussex, England: John Wiley & Sons, 2007.
Encontre o texto completo da fonteBreitmaier, E. Structure elucidation by NMR in organic chemistry: A practical guide. Chichester: Wiley, 1993.
Encontre o texto completo da fonteDiehl, P. In-vivo Magnetic Resonance Spectroscopy Ii. Editado por P. Diehl. Springer, 1992.
Encontre o texto completo da fonteGraaf, Robin A. De. In Vivo NMR Spectroscopy: Principles and Techniques. Wiley & Sons, Limited, John, 2007.
Encontre o texto completo da fonteBreitmaier, E. Structure Elucidation by NMR in Organic Chemistry. Wiley & Sons, Incorporated, John, 2002.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Spectroscopie RMN in vivo"
FLAMENT, Julien, Hélène RATINEY e Fawzi BOUMEZBEUR. "Spectroscopie RMN in vivo et imagerie métabolique". In Les enjeux de l’IRM, 243–84. ISTE Group, 2023. http://dx.doi.org/10.51926/iste.9113.ch9.
Texto completo da fonte"6. Expériences en RMN". In La spectroscopie à Résonance Magnétique Nucléaire, 97–122. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2368-0-008.
Texto completo da fonte"6. Expériences en RMN". In La spectroscopie à Résonance Magnétique Nucléaire, 97–122. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2368-0.c008.
Texto completo da fonteBorré, Leandro Bandeira, Rosane Aguiar da Silva San Gil, Anderson Thiago Vasconcelos Veiga e José Alberto Portela Bonapace. "RMN DE SÓLIDOS DE 13C COMO TÉCNICA DE PROSPECÇÃO DE DEPÓSITOS BILIARES EX VIVO". In Química e bioquímica: fundamentos e aplicações, 83–92. Atena Editora, 2023. http://dx.doi.org/10.22533/at.ed.2832328127.
Texto completo da fonte