Artigos de revistas sobre o tema "Small inhibitory compounds"
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Alvarez-Gonzalez, Juan Antonio, Robert Maul, Rahul M. Kohli e Patricia J. Gearhart. "Small molecule inhibitors of Activation-Induced Deaminase". Journal of Immunology 200, n.º 1_Supplement (1 de maio de 2018): 48.18. http://dx.doi.org/10.4049/jimmunol.200.supp.48.18.
Texto completo da fonteYan, Hua, Tomoko Chiba Mizutani, Nobuhiko Nomura, Tadakazu Takakura, Yoshihiro Kitamura, Hideka Miura, Masako Nishizawa, Masashi Tatsumi, Naoki Yamamoto e Wataru Sugiura. "A Novel Small Molecular Weight Compound with a Carbazole Structure That Demonstrates Potent Human Immunodeficiency Virus Type-1 Integrase Inhibitory Activity". Antiviral Chemistry and Chemotherapy 16, n.º 6 (dezembro de 2005): 363–73. http://dx.doi.org/10.1177/095632020501600603.
Texto completo da fonteAsai, Takashi, Tsutomu Takeuchi, Jeff Diffenderfer e L. David Sibley. "Identification of Small-Molecule Inhibitors of Nucleoside Triphosphate Hydrolase in Toxoplasma gondii". Antimicrobial Agents and Chemotherapy 46, n.º 8 (agosto de 2002): 2393–99. http://dx.doi.org/10.1128/aac.46.8.2393-2399.2002.
Texto completo da fontePatkar, Chinmay G., Martha Larsen, Michael Owston, Janet L. Smith e Richard J. Kuhn. "Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay". Antimicrobial Agents and Chemotherapy 53, n.º 10 (3 de agosto de 2009): 4103–14. http://dx.doi.org/10.1128/aac.00074-09.
Texto completo da fonteHan, Chun, Jiahong Ren, Feng Su, Xiaoqin Hu, Mengyao Li, Zhijun Wang e Lintao Wu. "Hybrids of Quinoline and Anilinopyrimidine: Novel EGFRT790M Inhibitors with Antiproliferative Activity against Non-Small Cell Lung Cancer Cell Lines". Anti-Cancer Agents in Medicinal Chemistry 20, n.º 6 (14 de junho de 2020): 724–33. http://dx.doi.org/10.2174/1871520620666200302113206.
Texto completo da fonteAbramić, Marija, e Dejan Agić. "Survey of Dipeptidyl Peptidase III Inhibitors: From Small Molecules of Microbial or Synthetic Origin to Aprotinin". Molecules 27, n.º 9 (7 de maio de 2022): 3006. http://dx.doi.org/10.3390/molecules27093006.
Texto completo da fonteNoueiry, Amine O., Paul D. Olivo, Urszula Slomczynska, Yi Zhou, Ben Buscher, Brian Geiss, Michael Engle et al. "Identification of Novel Small-Molecule Inhibitors of West Nile Virus Infection". Journal of Virology 81, n.º 21 (22 de agosto de 2007): 11992–2004. http://dx.doi.org/10.1128/jvi.01358-07.
Texto completo da fonteLefas, Georgia, e George Chaconas. "High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete". Antimicrobial Agents and Chemotherapy 53, n.º 10 (13 de julho de 2009): 4441–49. http://dx.doi.org/10.1128/aac.00529-09.
Texto completo da fonteErcan-Fang, Nacide, Miriam R. Taylor, Judith L. Treadway, Carolyn B. Levy, Paul E. Genereux, E. Michael Gibbs, Virginia L. Rath, Younggil Kwon, Mary C. Gannon e Frank Q. Nuttall. "Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors". American Journal of Physiology-Endocrinology and Metabolism 289, n.º 3 (setembro de 2005): E366—E372. http://dx.doi.org/10.1152/ajpendo.00264.2004.
Texto completo da fonteYoo, Jihye, Darong Kim, Jiyoung Park, Young-Kook Kim, Hea-Young Park Choo e Hyun Ae Woo. "Novel Small Molecule Inhibitors Targeting the IL-6/STAT3 Pathway or IL-1β". Molecules 27, n.º 9 (22 de abril de 2022): 2696. http://dx.doi.org/10.3390/molecules27092696.
Texto completo da fonteRamesh, Priyanka, e Shanthi Veerappapillai. "Designing Novel Compounds for the Treatment and Management of RET-Positive Non-Small Cell Lung Cancer—Fragment Based Drug Design Strategy". Molecules 27, n.º 5 (28 de fevereiro de 2022): 1590. http://dx.doi.org/10.3390/molecules27051590.
Texto completo da fonteGong, Mengdie, Mingyan Tu, Hongxia Sun, Lu Li, Lili Zhu, Honglin Li, Zhenjiang Zhao e Shiliang Li. "Design, Synthesis, and Structure–Activity Relationship Study of Potent MAPK11 Inhibitors". Molecules 27, n.º 1 (29 de dezembro de 2021): 203. http://dx.doi.org/10.3390/molecules27010203.
Texto completo da fonteTian, Tao, Guo-Ying Chen, Hao Zhang e Feng-Qing Yang. "Personal Glucose Meter for α-Glucosidase Inhibitor Screening Based on the Hydrolysis of Maltose". Molecules 26, n.º 15 (30 de julho de 2021): 4638. http://dx.doi.org/10.3390/molecules26154638.
Texto completo da fonteFlaumenhaft, Robert, Lynn VerPlank, James R. Dilks, Price S. Blair, Albert Mairuhu, Joseph Negri, Jason Burbank et al. "A Chemical Genetic Analysis of Platelet Activation." Blood 114, n.º 22 (20 de novembro de 2009): 4009. http://dx.doi.org/10.1182/blood.v114.22.4009.4009.
Texto completo da fonteChoi, Ryan, Mowei Zhou, Roger Shek, Jesse W. Wilson, Logan Tillery, Justin K. Craig, Indraneel A. Salukhe et al. "High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity". PLOS ONE 16, n.º 4 (22 de abril de 2021): e0250019. http://dx.doi.org/10.1371/journal.pone.0250019.
Texto completo da fonteRuseva, Nina, Hristina Sbirkova-Dimitrova, Mariyana Atanasova, Ana Marković, Žaklina Šmelcerović, Andrija Šmelcerović, Adriana Bakalova e Emiliya Cherneva. "Synthesis and DNase I Inhibitory Properties of New Squaramides". Molecules 28, n.º 2 (5 de janeiro de 2023): 538. http://dx.doi.org/10.3390/molecules28020538.
Texto completo da fonteHuang, Yuting, Zhaoxing Li, Yuan Ma, Qianqian Wu, Jianping Kong, Lijuan Zhao, Shunxiang Li e Juan Li. "Screening for Active Compounds of Acorus calamus against SARS-CoV-2 Viral Protease and Mechanism Prediction". Pharmaceuticals 17, n.º 3 (1 de março de 2024): 325. http://dx.doi.org/10.3390/ph17030325.
Texto completo da fonteSato, Yoshiaki, Ikuo Kashiwakura, Masaru Yamaguchi, Hironori Yoshino, Takeshi Tanaka, Ken Ikeda, Zhengmao Ye, Hirotsugu Komatsu, Takao Matsuzaki e Masato Hosoda. "Discovery of a Novel Small-molecule Interleukin-6 Inhibitor Through Virtual Screening Using Artificial Intelligence". Medicinal Chemistry 18, n.º 6 (julho de 2022): 694–700. http://dx.doi.org/10.2174/1573406418666211116144243.
Texto completo da fontePaiboonrungruang, chorlada. "Abstract 6237: Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 6237. http://dx.doi.org/10.1158/1538-7445.am2023-6237.
Texto completo da fonteJiang, Suping, Sean T. Prigge, Lan Wei, Yu-e. Gao, Thomas H. Hudson, Lucia Gerena, John B. Dame e Dennis E. Kyle. "New Class of Small Nonpeptidyl Compounds BlocksPlasmodium falciparum Development In Vitro by Inhibiting Plasmepsins". Antimicrobial Agents and Chemotherapy 45, n.º 9 (1 de setembro de 2001): 2577–84. http://dx.doi.org/10.1128/aac.45.9.2577-2584.2001.
Texto completo da fonteMoi, Davide, Alessandro Deplano, Andrea Angeli, Gianfranco Balboni, Claudiu T. Supuran e Valentina Onnis. "Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity". Molecules 27, n.º 17 (23 de agosto de 2022): 5370. http://dx.doi.org/10.3390/molecules27175370.
Texto completo da fonteAl-Sanea, Mohammad M. "Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold". PeerJ 8 (13 de março de 2020): e8649. http://dx.doi.org/10.7717/peerj.8649.
Texto completo da fonteGao, Yinghong, Stephen P. Davies, Martin Augustin, Anna Woodward, Umesh A. Patel, Robert Kovelman e Kevin J. Harvey. "A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery". Biochemical Journal 451, n.º 2 (28 de março de 2013): 313–28. http://dx.doi.org/10.1042/bj20121418.
Texto completo da fonteCruz-Migoni, Abimael, Peter Canning, Camilo E. Quevedo, Carole J. R. Bataille, Nicolas Bery, Ami Miller, Angela J. Russell, Simon E. V. Phillips, Stephen B. Carr e Terence H. Rabbitts. "Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds". Proceedings of the National Academy of Sciences 116, n.º 7 (25 de janeiro de 2019): 2545–50. http://dx.doi.org/10.1073/pnas.1811360116.
Texto completo da fonteRamshini, Hassan, Reza Tayebee, Alessandra Bigi, Francesco Bemporad, Cristina Cecchi e Fabrizio Chiti. "Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation". International Journal of Molecular Sciences 20, n.º 22 (7 de novembro de 2019): 5558. http://dx.doi.org/10.3390/ijms20225558.
Texto completo da fonteMinhas, Richa, e Yogita Bansal. "iNOS inhibitors: Benzimidazole-coumarin derivatives to combat inflammation". European Journal of Chemistry 13, n.º 3 (30 de setembro de 2022): 307–18. http://dx.doi.org/10.5155/eurjchem.13.3.307-318.2282.
Texto completo da fonteChattopadhyay, Shrikanta, Alison L. Stewart, Siddhartha Mukherjee, Cherrie Huang, Kimberly A. Hartwell, Peter G. Miller, Leigh Carmody et al. "Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma". Blood 120, n.º 21 (16 de novembro de 2012): 571. http://dx.doi.org/10.1182/blood.v120.21.571.571.
Texto completo da fonteAdachi, Ryutaro, Tsuyoshi Ishii, Shinichi Matsumoto, Takuya Satou, Junichi Sakamoto e Tomohiro Kawamoto. "Discovery of Human Intestinal MGAT Inhibitors Using High-Throughput Mass Spectrometry". SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, n.º 4 (8 de outubro de 2016): 360–65. http://dx.doi.org/10.1177/1087057116673181.
Texto completo da fonteMavridis, Evangelos, Eleftherios Bermperoglou, Eleni Pontiki e Dimitra Hadjipavlou-Litina. "5-(4H)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules". Molecules 25, n.º 14 (11 de julho de 2020): 3173. http://dx.doi.org/10.3390/molecules25143173.
Texto completo da fonteTrenholme, Katharine, Linda Marek, Sandra Duffy, Gabriele Pradel, Gillian Fisher, Finn K. Hansen, Tina S. Skinner-Adams et al. "Lysine Acetylation in Sexual Stage Malaria Parasites Is a Target for Antimalarial Small Molecules". Antimicrobial Agents and Chemotherapy 58, n.º 7 (14 de abril de 2014): 3666–78. http://dx.doi.org/10.1128/aac.02721-13.
Texto completo da fonteZhao, Hongchuan, Pu Sun, Wei Guo, Yi Wang, Ao Zhang, Linghua Meng e Chunyong Ding. "Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product". Molecules 24, n.º 6 (18 de março de 2019): 1059. http://dx.doi.org/10.3390/molecules24061059.
Texto completo da fonteFurbish, Amelia B., Ahmed S. Alford, Pieter Burger, Yuri K. Peterson, Tracy Murray-Stewart, Robert A. Casero e Patrick M. Woster. "Identification and Characterization of Novel Small-Molecule SMOX Inhibitors". Medical Sciences 10, n.º 3 (30 de agosto de 2022): 47. http://dx.doi.org/10.3390/medsci10030047.
Texto completo da fonteVENÄLÄINEN, Jarkko I., Risto O. JUVONEN, J. Arturo GARCIA-HORSMAN, Erik A. A. WALLÉN, Johannes A. M. CHRISTIAANS, Elina M. JARHO, Jukka GYNTHER e Pekka T. MÄNNISTÖ. "Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site". Biochemical Journal 382, n.º 3 (7 de setembro de 2004): 1003–8. http://dx.doi.org/10.1042/bj20040992.
Texto completo da fonteKollár, Levente, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry et al. "Fragment-Sized and Bidentate (Immuno)Proteasome Inhibitors Derived from Cysteine and Threonine Targeting Warheads". Cells 10, n.º 12 (6 de dezembro de 2021): 3431. http://dx.doi.org/10.3390/cells10123431.
Texto completo da fonteNordio, Giulia, Francesco Piazzola, Giorgio Cozza, Monica Rossetto, Manuela Cervelli, Anna Minarini, Filippo Basagni et al. "From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs". Molecules 28, n.º 17 (29 de agosto de 2023): 6329. http://dx.doi.org/10.3390/molecules28176329.
Texto completo da fonteMoon, Sungho, Seon Yeon Cho, Minhye Kim, Soojeong Beak, Jinhyuk Kim, Yongchan Kim, Sungil Park et al. "Abstract B142: Discovery of novel and potent TEAD inhibitors, orally available small molecules with anti-tumor activity in hippo pathway- dysregulated cancers". Molecular Cancer Therapeutics 22, n.º 12_Supplement (1 de dezembro de 2023): B142. http://dx.doi.org/10.1158/1535-7163.targ-23-b142.
Texto completo da fonteRusina, Polina, Erik Gandalipov, Yana Abdusheva, Maria Panova, Alexandra Burdenkova, Vasiliy Chaliy, Maria Brachs et al. "Imidazole-4-N-acetamide Derivatives as a Novel Scaffold for Selective Targeting of Cyclin Dependent Kinases". Cancers 15, n.º 15 (25 de julho de 2023): 3766. http://dx.doi.org/10.3390/cancers15153766.
Texto completo da fonteFrancini, Cinzia, Francesca Musumeci, Anna Fallacara, Lorenzo Botta, Alessio Molinari, Roberto Artusi, Laura Mennuni, Adriano Angelucci e Silvia Schenone. "Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors". Molecules 23, n.º 9 (17 de setembro de 2018): 2369. http://dx.doi.org/10.3390/molecules23092369.
Texto completo da fonteKulkarni, Amol A., Ayyiliath M. Sajith, Changwen Zhang, Jiukuan Hao e J. Phillip Bowen. "Small molecule prevents inflammation in microglia by targeting the NLRP3 inflammasome". Journal of Immunology 204, n.º 1_Supplement (1 de maio de 2020): 160.15. http://dx.doi.org/10.4049/jimmunol.204.supp.160.15.
Texto completo da fonteRampogu, Shailima, Ayoung Baek, Chanin Park, Shraddha Parate, Saravanan Parameswaran, Yohan Park, Baji Shaik, Ju Hyun Kim, Seok Ju Park e Keun Woo Lee. "Discovery of Small Molecules that Target Vascular Endothelial Growth Factor Receptor-2 Signalling Pathway Employing Molecular Modelling Studies". Cells 8, n.º 3 (21 de março de 2019): 269. http://dx.doi.org/10.3390/cells8030269.
Texto completo da fonteGising, Johan, Saman Honarnejad, Maaike Bras, Gemma L. Baillie, Stuart P. McElroy, Philip S. Jones, Angus Morrison, Julia Beveridge, Mathias Hallberg e Mats Larhed. "The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds". International Journal of Molecular Sciences 25, n.º 7 (6 de abril de 2024): 4084. http://dx.doi.org/10.3390/ijms25074084.
Texto completo da fonteCurreli, Francesca, Shahad Ahmed, Sofia M. B. Victor, Aleksandra Drelich, Siva S. Panda, Andrea Altieri, Alexander V. Kurkin, Chien-Te K. Tseng, Christopher D. Hillyer e Asim K. Debnath. "Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays". Viruses 14, n.º 1 (31 de dezembro de 2021): 69. http://dx.doi.org/10.3390/v14010069.
Texto completo da fonteElsawi, Ahmed E., Mai I. Shahin, Hager A. Elbendary, Tarfah Al-Warhi, Fatma E. Hassan e Wagdy M. Eldehna. "1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking". Pharmaceuticals 17, n.º 1 (8 de janeiro de 2024): 81. http://dx.doi.org/10.3390/ph17010081.
Texto completo da fontePorubin, Diana. "Inhibition of in Vitro Nitrosation of Nornicotine". Chemistry Journal of Moldova 2, n.º 1 (dezembro de 2007): 78–82. http://dx.doi.org/10.19261/cjm.2007.02(1).11.
Texto completo da fonteMontanari, Floriane, Anna Cseke, Katrin Wlcek e Gerhard F. Ecker. "Virtual Screening of DrugBank Reveals Two Drugs as New BCRP Inhibitors". SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, n.º 1 (11 de julho de 2016): 86–93. http://dx.doi.org/10.1177/1087057116657513.
Texto completo da fonteZhang, Hao, Feng-Qing Yang e Jian-Li Gao. "A Simple and Portable Personal Glucose Meter Method Combined with Molecular Docking for Screening of Lipase Inhibitors". Evidence-Based Complementary and Alternative Medicine 2022 (22 de setembro de 2022): 1–9. http://dx.doi.org/10.1155/2022/4430050.
Texto completo da fonteAlkhashrom, Sewar, Jintawee Kicuntod, Sigrun Häge, Johannes Schweininger, Yves A. Muller, Peter Lischka, Manfred Marschall e Jutta Eichler. "Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors". Viruses 13, n.º 3 (12 de março de 2021): 471. http://dx.doi.org/10.3390/v13030471.
Texto completo da fonteYang, Cheng-Wei, Yung-Ning Yang, Po-Huang Liang, Chi-Min Chen, Wei-Liang Chen, Hwan-You Chang, Yu-Sheng Chao e Shiow-Ju Lee. "Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus". Antimicrobial Agents and Chemotherapy 51, n.º 11 (20 de agosto de 2007): 3924–31. http://dx.doi.org/10.1128/aac.00408-07.
Texto completo da fonteLiargkova, Thalia, Nikolaos Eleftheriadis, Frank Dekker, Efstathia Voulgari, Constantinos Avgoustakis, Marina Sagnou, Barbara Mavroidi, Maria Pelecanou e Dimitra Hadjipavlou-Litina. "Small Multitarget Molecules Incorporating the Enone Moiety". Molecules 24, n.º 1 (7 de janeiro de 2019): 199. http://dx.doi.org/10.3390/molecules24010199.
Texto completo da fonteZhang, Yan, e Niefang Yu. "Design, Synthesis and Biological Evaluation: 5-amino-1H-pyrazole-1- carbonyl derivatives as FGFR Inhibitors". Letters in Drug Design & Discovery 17, n.º 11 (23 de outubro de 2020): 1330–41. http://dx.doi.org/10.2174/1570180817999200608140628.
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