Literatura científica selecionada sobre o tema "Sisters – death"
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Artigos de revistas sobre o assunto "Sisters – death"
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Scarcella, A., A. De Lucia, M. B. Pasquariello, and P. Gambardella. "Early death in two sisters with Hennekam syndrome." American Journal of Medical Genetics 93, no. 3 (2000): 181–83. http://dx.doi.org/10.1002/1096-8628(20000731)93:3<181::aid-ajmg3>3.0.co;2-b.
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Ellis, R. E., and H. R. Horvitz. "Two C. elegans genes control the programmed deaths of specific cells in the pharynx." Development 112, no. 2 (1991): 591–603. http://dx.doi.org/10.1242/dev.112.2.591.
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The genes ces-1 and ces-2 control the decisions of two cells in the nematode Caenorhabditis elegans to undergo programmed cell death. Mutations that cause a gain of ces-1 function or a reduction of ces-2 function prevent these cells, the sisters of the two pharyngeal NSM neurons, from dying. These mutations do not affect most other cell deaths. Genetic studies indicate that ces-1 and ces-2 affect the fates of the NSM sisters by regulating the genes required for all programmed cell deaths to occur.
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Moss, Miriam S., and Sidney Z. Moss. "Meaning of the Death of an Elderly Father: Two Sisters' Perspectives." OMEGA - Journal of Death and Dying 66, no. 3 (2013): 195–213. http://dx.doi.org/10.2190/om.66.3.a.
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Multiple bereaved adult children, as siblings, have rarely been studied. We expand the paradigm of bereavement research to explore the ways that two sisters describe the experience and meaning of the death of their elderly father. The two sisters each participated in two separate qualitative ethnographic interviews, followed by standard qualitative analyses of the transcribed narratives. The findings yield contrasting perspectives of the sisters' disparate views of their family, of their father, and their views of each other, that provide insight into the complexity of the sharp differences in their reactions to their father's death. Their views of their father's death reflected their particular relationship with their father, their non-shared experiences over the life course, and their personal world views. Differences and contradictions in the views of multiple siblings can broaden our understanding of bereavement and of the processes central to parent-child ties at the end of life.
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Hellman, Jesse M. "Mourning Agnes: The Hidden Impact on Bernard Shaw of the Death of His Sister." Shaw 42, no. 2 (2022): 327–55. http://dx.doi.org/10.5325/shaw.42.2.0327.
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ABSTRACT We know very little about Bernard Shaw’s sister Elinor Agnes beyond that she died from consumption just shy of twenty-two years of age. Shaw spoke so little of her, revealing so little of his feelings for her, that we might wonder how important Agnes was to him and how her death affected him. Searching for what is known of Agnes led to a number of clues suggesting a close bond existed between Shaw and his sister. Shaw’s silence regarding the dates of the deaths of his sisters Lucy and Agnes speaks of unresolved mourning and complicated grief. What led Shaw to so protect himself from the emotional pain it appears he experienced from death and loss? Importantly, it appears that Shaw’s memories of Agnes and his wishes for her contributed to the creation of his iconic young heroines.
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Bogatova, S. M. "The linguistic sensorium of death in “The sisters” by James Joyce." Science of the Person: Humanitarian Researches 14, no. 2 (2020): 23–30. http://dx.doi.org/10.17238/issn1998-5320.2020.14.2.4.
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Houlston, Richard S., Jayne Hampson, William P. Collins, Malcolm I. Whitehead, Stuart Campbell, and Joan Slack. "Correlation in ages at death from familial ovarian cancer among sisters." Gynecologic Oncology 47, no. 2 (1992): 253–54. http://dx.doi.org/10.1016/0090-8258(92)90115-y.
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Jiao, Xinbo. "Representation and Rhizome: A Brief Analysis on the Priest’s Death in Sisters." Journal of Education and Educational Research 9, no. 1 (2024): 255–58. http://dx.doi.org/10.54097/3n316j78.
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The cause of death of the priest in Sisters, as an imagery factor, affects the readers’ understanding on the text. This paper discusses the cause of death of the priest by analyzing the representations of the text, the reality and the author, and studying the literary text, the reality and the author's experience under the equal discourse. This paper finds that all kinds of appearances caused by the death of priests points to the direction- the reality of the collapse of Irish traditional values in the early 20th century and the arduous task of reviving Irish traditional morality.
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Rakocevic, Selena. "The Jankovic sisters and kinetography Laban." Muzikologija, no. 24 (2018): 151–72. http://dx.doi.org/10.2298/muz1824151r.
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Based on the archival material from the Legacy of Sisters Jankovic, which is stored in the National Library of Serbia, this article critically examines Ljubica and Danica Jankovic?s relation to today?s world-renowned dance notation, kinetography Laban. The analyzed archival material includes the transcript of the first edition of Laban?s notation called Schrifttanz in German, as well as several unpublished manuscripts by Ljubica Jankovic. Even though the Jankovic sisters were familiar with kinetography Laban, they (especially Ljubica) were its great opponents. Instead of learning and using kinetography Laban, they developed their own dance notation system in early 1930s and used it until Ljubica?s death in 1974. In this article, the relationship of the Jankovic sisters? dance notation to Rudolf Laban?s kinetography is considered in the context of the wider processes of development of ethnochoreology, traditional dance notations, as well as the history of kinetography Laban in Europe in the first half and mid-20th century.
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Doctor, Henry V., Sally E. Findley, and Godwin Y. Afenyadu. "Estimating Maternal Mortality Level in Rural Northern Nigeria by the Sisterhood Method." International Journal of Population Research 2012 (September 12, 2012): 1–5. http://dx.doi.org/10.1155/2012/464657.
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Maternal mortality is one of the major challenges to health systems in sub Saharan Africa. This paper estimates the lifetime risk of maternal death and maternal mortality ratio (MMR) in four states of Northern Nigeria. Data from a household survey conducted in 2011 were utilized by applying the “sisterhood method” for estimating maternal mortality. Female respondents (15–49 years) were interviewed thereby creating a retrospective cohort of their sisters who reached the reproductive age of 15 years. A total of 3,080 respondents reported 7,731 maternal sisters of which 593 were reported dead and 298 of those dead were maternal-related deaths. This corresponded to a lifetime risk of maternal death of 9% (referring to a period about 10.5 years prior to the survey) and an MMR of 1,271 maternal deaths per 100,000 live births; 95% CI was 1,152–1,445 maternal deaths per 100,000 live births. The study calls for improvement of the health system focusing on strategies that will accelerate reduction in MMR such as availability of skilled birth attendants, access to emergency obstetrics care, promotion of facility delivery, availability of antenatal care, and family planning. An accelerated reduction in MMR in the region will contribute towards the attainment of the Millennium Development Goal of maternal mortality reduction in Nigeria.
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Luo, Jia. "Multimodal Discourse Analysis, audiovisual translation, The Broke Sisters." Frontiers in Humanities and Social Sciences 4, no. 7 (2024): 60–67. http://dx.doi.org/10.54691/1byq4m72.
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China's Insurance Law defines "workers who have a labor relationship with the insured" for pure economic interests. According to the current law, when an employer purchases insurance for its employees, the transfer of the insurance claim right can be effective. In this case, should the share of the income of the employer, as a non-natural person, when receiving the employee's death insurance be restricted? This issue is not explicitly stipulated in the law and needs to be discussed. In light of social reality, this article believes that the employer's share of benefits in group accident insurance should be restricted by amending the Insurance Law or supplementing judicial interpretations. If necessary, content that favors the insured and their families can be added. This will save losses and prevent the employer from using the employment relationship to infringe on the legitimate interests of employees.
Teses / dissertações sobre o assunto "Sisters – death"
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Forward, Debbie. "The search for new meaning : adolescent bereavement after the sudden death of a sibling: a grounded theory study /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ62385.pdf.
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Woodrow, Eleferia. "The experience of the loss of a sibling : A phenomenological study /." Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-04252007-134513.
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Legg, Susan C. "The developmental implications of childhood bereavement." CSUSB ScholarWorks, 1994. https://scholarworks.lib.csusb.edu/etd-project/487.
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Burner, Colleen. "Sister Golden Calf: Stories, Dissections, & A Novella." PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/2081.
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Children find decomposing bodies on a beach. A girl becomes a ghost and finds someone. A dog dies but its owner is out of his mind and eating waffles. Sheep are a perfect species. A woman experiences a pregnancy that is out of this world! A raccoon dies and you watch its body break down. A father does his best fathering.
You take a textual road-trip tour of America’s oldest hobby. A trauma is slowed down, picked apart. A soupfin shark is dissected and you watch. A homestead becomesa ghost town in rural Oregon. Joseph Beuys is an artist.
A sister falls in love with an object, has a difference of opinion with her sister.
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Roche, Rosa M. "Death of a Brother or Sister: Siblings' Perception of their Health, Treatments and the Associated Health Care Costs." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1519.
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Death of a child is a very painful experience for parents and remaining siblings who experience physiological and emotional symptoms as described by the parents. There are few reports from the remaining siblings on their physical and emotional health and even less data on their treatments and associated health care costs after sibling loss. The purpose of this study in children who have lost a sibling in the NICU/PICU, ER or those who have been sent home on technology dependent equipment to die, is to compare parents’ and children’s perceptions of the surviving sibling’s health, identify factors related to these perceptions, and describe treatments for the sibling’s physical and mental health at 2 and 4 months after a sibling’s death. Sixty four surviving siblings and their parents reported on the siblings’ mental and overall health. Available treatment charges (visits to the emergency room, physician office, hospitalization, and any health services (mental & physical) since the sibling death were collected from bills and insurance receipts. Cause of child death (acute or chronic) was collected from the deceased child’s hospital record. The relationship between parent and sibling’s perception of the surviving sibling’s health, and anxiety and depression at 2 and 4 months post the death were measured using the Children’s Depression Inventory and the Spence Anxiety Scales. Data were analyzed using: T-Tests, ANOVA, Pearson correlations, frequencies and descriptive statistics. Findings indicated that at 2 and 4 months parent’s perceived their surviving siblings’ health to be better than the child perceived his/her health to be. At 4 months fathers rated the siblings’ health compared to their peers lower than the siblings. Greater child anxiety was related to lower father’s ratings of the child’s health now and compared to peers. Treatments and charges increased from 2 months to 4 months with males having more treatments than females. The majority of the treatments consisted of routine physician visits, non-routine physician visits, emergency room/urgent care visits and counseling. Study findings can help guide healthcare providers and educators in identifying those children that are at high risk for negative health effects after the death of a sibling.
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Moraes, Marina Frolini [UNESP]. "Avaliação de sistema de vigilância de óbitos perinatais em hospital terciário do interior paulista, 2014/2015." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/143965.
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Previous issue date: 2016-08-22<br>A vigilância epidemiológica é essencial para o planejamento, implementação e avaliação das práticas de saúde pública. O monitoramento da mortalidade perinatal, dentro do sistema de vigilância epidemiológica, depende da qualidade dos dados dos sistemas de informação. Objetivo: Avaliar o sistema de vigilância de óbitos perinatais de Núcleo Hospitalar de Epidemiologia (NHE) de hospital terciário do interior paulista. Métodos: Trata-se de estudo transversal, realizado a partir dos 80 óbitos ocorridos entre abril de 2014 e abril de 2015 em NHE de hospital terciário do interior paulista. O referencial de avaliação utilizado foi proposto pelo Center for Disease Control americano para uso em saúde pública. Foram abordados os seguintes atributos: utilidade, simplicidade, qualidade dos dados, aceitabilidade, sensibilidade, representatividade, oportunidade, flexibilidade, valor preditivo positivo, estabilidade. Este estudo foi aprovado por Comitê de Ética em Pesquisa local. Resultados: Utilidade: o sistema é pouco utilizado, os dados não são devolvidos aos profissionais, não são utilizados na proposição de ações para evitar a ocorrência de novos casos nem na gestão em saúde. Qualidade dos dados: 6,2% das variáveis estavam em branco nas investigações; a taxa de concordância entre as investigações originais e as realizadas para o estudo foi de 79,1%, sendo que a categoria com maior discordância/ausência de dados foi assistência ao parto (35,8%). Simplicidade: a grande maioria (91,2%) das investigações foi realizada a partir de apenas uma fonte de dados e o tempo médio gasto na investigação de óbitos infantis foi 63,4 minutos com intervalo interquartil de 29,2 minutos e de óbito fetal, 27,3 minutos com intervalo interquartil de 12,5 minutos. Aceitabilidade: nenhum caso de óbito foi notificado pelos atores envolvidos. Sensibilidade: há problemas a serem superados pelo NHE e Núcleo de Vigilância Epidemiológica. Representatividade: 96,8% dos óbitos do município ocorreram no Hospital do estudo. Oportunidade: o tempo entre a ocorrência do óbito e o encaminhamento ao município da investigação completa foi de 15,7 dias. Flexibilidade: o sistema foi considerado flexível. Valor preditivo positivo: todas as investigações de 2015 foram realizadas a partir da Declaração de Óbito e eram compatíveis com os casos. Estabilidade: alguns problemas eventuais foram apontados, tecnológicos ou por deficiências de recursos humanos. Conclusões: Para aprimorar o sistema de vigilância de óbitos perinatais será necessário: implementar ações voltadas aos diferentes profissionais atuantes na área materno infantil do hospital, para que passem a informar os casos ao NHE e para aprimorar a qualidade dos registros de dados nos prontuários; implementar busca ativa de óbitos perinatais em todas as unidades hospitalares que atendem gestantes e recém-nascidos e buscar mecanismos que permitam identificar, além dos óbitos infantis, os óbitos fetais pelo sistema de informática do hospital.<br>Epidemiological surveillance is essential for the planning, implementation and evaluation of public health practices. The monitoring of perinatal mortality, within the system of epidemiological surveillance, depends on quality of data in information systems. Object: To evaluate the perinatal deaths surveillance system of the Hospital Nucleus of Epidemiology (HNE) of a tertiary referral hospital in the interior of São Paulo state. Methods: A transversal study was conducted based on 80 deaths between April 2014 and April 2015 at the HNE of a tertiary referral hospital in the interior of São Paulo state. Our evaluation references were proposed by the American Center for Disease Control to be used in public health. The following attributes were addressed: utility, simplicity, data quality, acceptability, sensitivity, representativeness, timeliness, flexibility, predictive value positive, and stability. This study was approved by the local Research Ethics Committee. Results: Utility: the system is little used, the data are not returned to professionals, they are used neither in action proposals in order to avoid the emergence of new cases, nor in health management. Data quality: 6.2% of variables were blank in investigations; the agreement rate between original investigations and the ones conducted for the study was 79.1%, of which the category with the greatest disagreement/lack of data was birth assistance (35.8%). Simplicity: the vast majority (91.2%) of investigations was conducted on a single source of data, and the average time spent on investigating infant deaths was 63.4 minutes, with interquartile range of 29.2 minutes and 27.3 minutes with interquartile range of 12.5 minutes on fetal deaths. Acceptability: no death was reported by the individuals involved. Sensitivity: there are issues to be overcome by the NHE and the Epidemiological Surveillance Nucleus. Representativeness: 96.8% of deaths in the municipality occurred in the hospital under study. timeliness: the time span between death and referring the complete investigation to the municipality was 15.7 days. Flexibility: the system was considered flexible. Predictive value positive: all investigations in 2015 were conducted based on the date of death and were compatible with the cases. Stability: some possible problems (of a technological nature or due to lack of staff) were highlighted. Conclusions: To have a better surveillance system for perinatal deaths, it will be necessary to: implement actions geared at different professionals working at the maternity and child ward of the hospital so that they begin to report cases to the HNE and improve the quality of records in patients’ files; to implement an active search of perinatal deaths in all hospital units dealing with pregnant women and newborns and to search for mechanisms that make it possible to identify, besides infant deaths, fetal deaths by means of the hospital’s IT system.
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Moraes, Marina Frolini. "Avaliação de sistema de vigilância de óbitos perinatais em hospital terciário do interior paulista, 2014/2015." Botucatu, 2016. http://hdl.handle.net/11449/143965.
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Orientador: Cristina Maria de Lima Parada<br>Resumo: A vigilância epidemiológica é essencial para o planejamento, implementação e avaliação das práticas de saúde pública. O monitoramento da mortalidade perinatal, dentro do sistema de vigilância epidemiológica, depende da qualidade dos dados dos sistemas de informação. Objetivo: Avaliar o sistema de vigilância de óbitos perinatais de Núcleo Hospitalar de Epidemiologia (NHE) de hospital terciário do interior paulista. Métodos: Trata-se de estudo transversal, realizado a partir dos 80 óbitos ocorridos entre abril de 2014 e abril de 2015 em NHE de hospital terciário do interior paulista. O referencial de avaliação utilizado foi proposto pelo Center for Disease Control americano para uso em saúde pública. Foram abordados os seguintes atributos: utilidade, simplicidade, qualidade dos dados, aceitabilidade, sensibilidade, representatividade, oportunidade, flexibilidade, valor preditivo positivo, estabilidade. Este estudo foi aprovado por Comitê de Ética em Pesquisa local. Resultados: Utilidade: o sistema é pouco utilizado, os dados não são devolvidos aos profissionais, não são utilizados na proposição de ações para evitar a ocorrência de novos casos nem na gestão em saúde. Qualidade dos dados: 6,2% das variáveis estavam em branco nas investigações; a taxa de concordância entre as investigações originais e as realizadas para o estudo foi de 79,1%, sendo que a categoria com maior discordância/ausência de dados foi assistência ao parto (35,8%). Simplicidade: a grande maioria (91,2%) das ... (Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: Epidemiological surveillance is essential for the planning, implementation and evaluation of public health practices. The monitoring of perinatal mortality, within the system of epidemiological surveillance, depends on quality of data in information systems. Object: To evaluate the perinatal deaths surveillance system of the Hospital Nucleus of Epidemiology (HNE) of a tertiary referral hospital in the interior of São Paulo state. Methods: A transversal study was conducted based on 80 deaths between April 2014 and April 2015 at the HNE of a tertiary referral hospital in the interior of São Paulo state. Our evaluation references were proposed by the American Center for Disease Control to be used in public health. The following attributes were addressed: utility, simplicity, data quality, acceptability, sensitivity, representativeness, timeliness, flexibility, predictive value positive, and stability. This study was approved by the local Research Ethics Committee. Results: Utility: the system is little used, the data are not returned to professionals, they are used neither in action proposals in order to avoid the emergence of new cases, nor in health management. Data quality: 6.2% of variables were blank in investigations; the agreement rate between original investigations and the ones conducted for the study was 79.1%, of which the category with the greatest disagreement/lack of data was birth assistance (35.8%). Simplicity: the vast majority (91.2%) of investigations was cond... (Complete abstract click electronic access below)<br>Mestre
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Marqués, Fernández Fernando. "Activation of survival pathways triggered by death receptors in the nervous system." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/116312.
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La activación del Receptor del Factor de Necrosis Tumoral de tipo 1 (TNFR1) por parte de su
ligando específico, TNFα, induce la muerte celular mediante la formación de un complejo de
señalización inductor de muerte (DISC) que contiene caspasa-8 junto con las proteína
adaptadoras FADD, TRADD, TRAF2, y RIP. Este complejo provoca la activación de caspasa-8
que lleva a la apoptosis. Sin embargo, TNFR1 también puede iniciar la activació de vías de
señalización relacionadas con la superviviencia celular y la diferenciación, tales como el factor
de transcripción NF-kB o la vía MAPK/ERK. De hecho, en la mayoría de tipos celulares se ha
demostrado que la señalización de supervivencia iniciada por TNFα debe ser bloqueada para
inducir la muerte celular apoptótica. Esto se ha conseguido clásicamente mediante el cotratamento
con inhibidores de la síntesis proteíca como Actinomicina D o Cicloheximida, o
mediante la inhibición directa de la vía de NF-kB a través de inhibidores químicos o la sobreexpresión
de una forma no degradable de IkBα. Un trabajo previo de nuestro própio laboratorio
reveló que la Actinomicina D sensibiliza las células PC12 y las neuronas corticales a la
apoptosis inducida por TNFα a través de una disminución en la expression de la proteína
antiapoptótica Bcl-XL. No obstante, les resultados demostraron que este efecto era
independiente de NF-kB o de otras proteínas antiapoptóticas como FLIP-L o las IAPs. En esta
tesis se analiza la activación de vías de supervivencia por parte de TNFα. En particular, he
establecido una relación entre la activació de NF-kB y la vía de MAPK/ERK. He utilizado la
línea celular PC12, un modelo bien establecido de células neuronales. La inhibición de la vía de
NF-kB en estas células indujo la reducción de la expression de FLIP-L. Mis resultados indican
que la activación de la vía MAPK/ERK depende de FLIP-L. Además, esta cascada de
señalización no implica la clásica activación de Ras, la proteina efectora que actúa por encima
en la vía. Sin embargo, la MAPKKK Raf-1 es necesaria para inducir la fosforilación de ERK1/2,
lo que sugiere que FLIP-L podria substituir a Ras en su función. Los resultados de esta tesis
también demuestran que la vía MAPK/ERK protege a las células de la apoptosis inducida por
TNFα, dado que la inhibición de esta señalización sensibiliza las células PC12 a la muerte
celular inducida por TNFα de forma similar a la sensibilización conseguida mediante la
inhibición de NF-kB. La caracterización de esta señalización apoptótica muestra la implicación
de JNK, que es necesaria para inducer la muerte celular cuando NF-kB está bloqueado y
cuando se inhibe MAPK/ERK. Es más, JNK induce un aumento en la expresión de Bim, una
proteina BH3-only relacionada clásicamente con la apotosis.
En resumen, esta tesis establece la relevancia de la vía MAPK/ERK como regulador
negativo de la apoptosis inducida por TNFα. Es importante destacar que los resultados
obtenidos revelan que NF-kB es crucial para la inducción de la fosforilación de ERK1/2 por
TNFα, y que estas vías de señalización estan relacionadas a través de la proteína
antiapoptótica FLIP-L.<br>Activation of the Tumor Necrosis Factor Receptor 1 (TNFR1) by its ligand TNFα
induces cell death through recruitment of a Death Inducing Signaling Complex (DISC)
containing caspase-8 and the adaptor proteins FADD, TRADD, TRAF2 and RIP. This
complex causes the cleavage and activation of caspase-8 that leads to apoptosis.
However, TNFR1 can also trigger activation of signaling pathways related to cell
survival and differentiation, such as the transcription factor NF-kB or MAPK/ERK. In
fact, in most cell types it has been shown that survival signaling by TNFα needs to be
abrogated in order to induce apoptotic cell death. This has been classically achieved
by co-treatment with protein synthesis inhibitors such as Actinomycin D or
Cycloheximide, or by direct inhibition of the NF-kB pathway through chemical inhibitors
or overexpression of a non-degradable form of IkBα. A previous report in our lab
revealed that Actinomycin D sensitizes PC12 cells and cortical neurons to TNFα-
induced apoptosis through down-regulation of the antiapoptotic protein Bcl-XL.
However, the results showed that this effect was independent of NF-kB or other
antiapoptotic proteins such as FLIP-L or IAPs. This thesis analyses the activation of
survival pathways by TNFα. In particular, I have established a link between the
activation of NF-kB and the MAPK/ERK pathway. I have used PC12 cells, a wellknown
model of neuronal cells. Inhibition of the NF-kB pathway in these cells induced a
downregulation of the antiapoptotic FLIP-L. My results indicate that TNFα-induced
activation of the MAPK/ERK pathway depends on FLIP-L. Furthermore, this signaling
cascade does not involve the classical activation of the upstream effector Ras.
However, the MAPKKK Raf-1 is necessary to induce ERK1/2 phosphorylation, thus
suggesting that FLIP-L subtitutes Ras in this function. The results of this thesis also
demonstrate that the MAPK/ERK pathway affords protection from TNFα-induced
apoptosis, since abrogation of this signaling cascade renders PC12 sensitive to cell
death induced by TNFα in a manner similar to sensitization achieved by NF-kB
inhibition. Characterization of the apoptotic pathway shows the implication of JNK,
which is necessary to induce cell death when NF-kB is blocked and when MAPK/ERK
is inhibited. Moreover, JNK induces the upregulation of Bim, a BH3-only protein
classically linked tot the induction of apoptosis.
Altogether, this thesis establishes the relevance of the MAPK/ERK pathway as
a negative regulator of TNFα-induced apoptosis. Importantly, the results obtained
reveal that NF-kB is crucial for the induction of ERK1/2 phosphorylation by TNFα, and
that this pathways are linked through the antiapoptotic protein FLIP-L.
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Braganholi, Danilo Faustino [UNESP]. "Uso da farmacogenética cardiovascular na análise e prevenção de doenças cardiovasculares e classificação em haplogrupos pelo cromossomo Y e DNA mitocondrial." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/88001.
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000694394.pdf: 608461 bytes, checksum: dceff09293ceb64124b8735297fa48e3 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Morte súbita cardíaca (MSC) é um dos maiores problemas de saúde pública no mundo, afetando cerca de 335 mil pessoas por ano nos EUA e aproximadamente 712 pessoas por dia no Brasil, predominantemente na faixa etária mais produtiva. Principalmente em jovens, as causas são desordens cardíacas com anormalidades estruturais e arritmogênicas de origens genéticas; além disso, alguns medicamentos podem influenciar na susceptibilidade a MSC ou a doenças cardiovasculares. Como a morte pode ocorrer num período máximo de uma hora após o início dos sintomas e não ser decorrente de trauma ou violência, o diagnóstico da causa de morte pode ser dificultado. A análise genética nestes casos é muito útil para ajudar a identificá-la e informar aos parentes próximos sobre um possível fator genético de risco pré-existente. Este trabalho propôs padronizar as reações de PCR e SNaPshot em multiplex para analisar 11 SNPs (single nucleotide polymorphisms) relacionados à MSC (NEWTON-CHEH et al. 2009) em grupos de familiares brasileiros com histórico de insuficiência cardíaca para uma futura utilização na Genética Forense e Médica, entretanto, o multiplex contendo 8 SNPs mostrou ser mais eficiente . Para tanto, amostras foram coletadas de indivíduos com histórico familiar de: coronariopatia, cardiomiopatia hipertrófica ou familiar próximo que sofreu ataque cardíaco e, indivíduos sem este histórico utilizados como controles. As análises não apresentaram diferenças significativas entre o grupo de indivíduos com histórico e controle, mas, os dados são compatíveis com as freqüências conhecidas dos SNPs. Também identificou-se um provável fator hereditário para o SNP rs4725982 em uma das famílias<br>Sudden cardiac death (SCD) is a major public health problems worldwide, affeting about 335,000 people per year in the U.S. and approximately 712 people per day in Brazil, predominantly in the most productive age group. Especially in young people, the causes are structural abnormalities of cardiac disorders and genetic origins of arrhythmogenic, in addition, some medications may influence susceptibility to SCD or cardiovascular disease. As death can occur whitin a maximum of one hour after onset of symptoms and not be due to trauma or violence, the diagnosis of the cause of the death can be difficult. Genetic analysis in these cases is very useful to help identify them and inform close relatives about a possible genetic risk factor pre-existing. This work proposed to standardize the PCR and SNaPshot multiplex to analyze 11 SNPs (single nucleotide polymorphisms) related to the SCD (NEWTON-CHEH et al. 2009) in Brazilian familial groups with a history of heart failure for future use in Forensic Genetics and Medical. For this, samples were collected from individuals with a family history of heart disease, hypertrophic cardiomyophathy or close relative who suffered a heart attack, and individuals without this history used as controls. The analysis showed no siginificant differences between the group of the individuals with a history and control, but the data are compatible with the frequencies of known SNPs. It also identified a probable hereditary factor for the SNP rs4725982 in one of the studied families
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Braganholi, Danilo Faustino. "Uso da farmacogenética cardiovascular na análise e prevenção de doenças cardiovasculares e classificação em haplogrupos pelo cromossomo Y e DNA mitocondrial /." Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/88001.
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Orientador: Regina Maria Barretto Cicarelli<br>Banca: Rogério Nogueira de Oliveira<br>Banca: Greiciane Gaburro Panetto<br>Resumo: Morte súbita cardíaca (MSC) é um dos maiores problemas de saúde pública no mundo, afetando cerca de 335 mil pessoas por ano nos EUA e aproximadamente 712 pessoas por dia no Brasil, predominantemente na faixa etária mais produtiva. Principalmente em jovens, as causas são desordens cardíacas com anormalidades estruturais e arritmogênicas de origens genéticas; além disso, alguns medicamentos podem influenciar na susceptibilidade a MSC ou a doenças cardiovasculares. Como a morte pode ocorrer num período máximo de uma hora após o início dos sintomas e não ser decorrente de trauma ou violência, o diagnóstico da causa de morte pode ser dificultado. A análise genética nestes casos é muito útil para ajudar a identificá-la e informar aos parentes próximos sobre um possível fator genético de risco pré-existente. Este trabalho propôs padronizar as reações de PCR e SNaPshot em multiplex para analisar 11 SNPs (single nucleotide polymorphisms) relacionados à MSC (NEWTON-CHEH et al. 2009) em grupos de familiares brasileiros com histórico de insuficiência cardíaca para uma futura utilização na Genética Forense e Médica, entretanto, o multiplex contendo 8 SNPs mostrou ser mais eficiente . Para tanto, amostras foram coletadas de indivíduos com histórico familiar de: coronariopatia, cardiomiopatia hipertrófica ou familiar próximo que sofreu ataque cardíaco e, indivíduos sem este histórico utilizados como controles. As análises não apresentaram diferenças significativas entre o grupo de indivíduos com histórico e controle, mas, os dados são compatíveis com as freqüências conhecidas dos SNPs. Também identificou-se um provável fator hereditário para o SNP rs4725982 em uma das famílias<br>Abstract: Sudden cardiac death (SCD) is a major public health problems worldwide, affeting about 335,000 people per year in the U.S. and approximately 712 people per day in Brazil, predominantly in the most productive age group. Especially in young people, the causes are structural abnormalities of cardiac disorders and genetic origins of arrhythmogenic, in addition, some medications may influence susceptibility to SCD or cardiovascular disease. As death can occur whitin a maximum of one hour after onset of symptoms and not be due to trauma or violence, the diagnosis of the cause of the death can be difficult. Genetic analysis in these cases is very useful to help identify them and inform close relatives about a possible genetic risk factor pre-existing. This work proposed to standardize the PCR and SNaPshot multiplex to analyze 11 SNPs (single nucleotide polymorphisms) related to the SCD (NEWTON-CHEH et al. 2009) in Brazilian familial groups with a history of heart failure for future use in Forensic Genetics and Medical. For this, samples were collected from individuals with a family history of heart disease, hypertrophic cardiomyophathy or close relative who suffered a heart attack, and individuals without this history used as controls. The analysis showed no siginificant differences between the group of the individuals with a history and control, but the data are compatible with the frequencies of known SNPs. It also identified a probable hereditary factor for the SNP rs4725982 in one of the studied families<br>Mestre
Livros sobre o assunto "Sisters – death"
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Handler, Jessica. Invisible sisters: A memoir. PublicAffairs, 2009.
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Belber, Stephen. The death of Frank. Dramatists Play Service, 2003.
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Loudon, Mary. Relative stranger: A sister's life after death. Canongate, 2007.
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Hutchinson, Vicki. Death by choice. Sid Harta Publishers, 2014.
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Alexander, Jeff. The sisters' tragedy: An anachronism in five acts. Paper Frog Productions, 2005.
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Martin, Nancy. A crazy little thing called death : a Blackbird Sisters mystery. Center Point Pub., 2009.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Sisters – death"
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Macleod, Joseph. "To the Death of Joachim." In The Sisters d' Aranyi. Routledge, 2021. http://dx.doi.org/10.4324/9781003228684-5.
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Prentis, Barbara. "Tragedy, Death and Eschatology." In The Brontë Sisters and George Eliot. Palgrave Macmillan UK, 1988. http://dx.doi.org/10.1007/978-1-349-08502-6_7.
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Lindsay, Mary, and Dermod MacCarthy. "Caring for the brothers and sisters of a dying child*." In Care of the Child Facing Death. Routledge, 2022. http://dx.doi.org/10.4324/9781003285434-16.
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Stone, Rachel. "Sisters Prepare Death for Sisters, Aunts for Nieces? The Missing Competition between Carolingian Women." In Haut Moyen Âge. Brepols Publishers, 2018. http://dx.doi.org/10.1484/m.hama-eb.5.114113.
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Fulford, Tim. "Death of Mrs. Wesley. Wesley's Sisters. Wesley at Epworth." In Robert Southey, The Life of Wesley; and the Rise and Progress of Methodism. Routledge, 2022. http://dx.doi.org/10.4324/9781032211114-1.
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Fernie, Ewan, and Simon Palfrey. "The Weird Sisters (from The Life and Death of the Brothers Macbeth)." In Reinventing the Renaissance. Palgrave Macmillan UK, 2013. http://dx.doi.org/10.1057/9781137319401_8.
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Moloney, Brian. "“My Sister Death”." In Francis of Assisi and His "Canticle of Brother Sun" Reassessed. Palgrave Macmillan US, 2013. http://dx.doi.org/10.1057/9781137361691_7.
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Jeune, Bernard, and Michel Poulain. "Emma Morano – 117 Years and 137 Days." In Demographic Research Monographs. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-49970-9_18.
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AbstractEmma Morano was born on 29 November 1899 in a small mountain village in Piemonte, and died on 15 April 2017 in Verbania on Lake Maggiore (100 km north of Milano). She was the daughter of Giovanni Morano, a miner; and Mathilde Bresciani, aged 24, a weaver. She was the first child in the family, and her arrival was followed by the births of seven siblings, four sisters and three brothers, all of whom she all survived. On 16 October 1926, Emma Morano married Giovanni Martinuzzi, but they separated a few years later after the death of their child. For more than 30 years, she worked in a jute factory. She then worked for about 20 years in the kitchen of a Marianist boarding school until she retired at the age of 75. After retirement, she lived in a small two-room apartment. In her final years, her hearing and sight were greatly reduced, but she could recognise faces and could communicate when spoken to loudly. She seemed to remember both past events and more recent ones. She had never been hospitalised, but had been treated for gastrointestinal bleeding and for urinary infections. She took no drugs regularly except laxatives. In the archives of four municipalities in the region, we obtained copies of the death certificates of her parents, the birth certificates of all of her siblings, her marriage certificate, and the birth and death certificates of her child. We found no inconsistences in the documents.
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Martin, Susan K., Caroline Daley, Elizabeth Dimock, Cheryl Cassidy, and Cecily Devereux. "Death of a Sister of Mercy." In Women and Empire, 1750–1939. Routledge, 2021. http://dx.doi.org/10.4324/9781003101857-44.
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Bickel, Sharon E., and Terry L. Orr-Weaver. "Regulation of Sister-Chromatid Cohesion During Drosophila Meiosis." In Germ Cell Development, Division, Disruption and Death. Springer New York, 1998. http://dx.doi.org/10.1007/978-1-4612-2206-4_5.
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Heckler, Wesllei Felipe, Juliano Varella de Carvalho, and Jorge Luis Victória Barbosa. "Thoth: An intelligent model for assisting individuals with suicidal ideation." In Anais Estendidos do Simpósio Brasileiro de Sistemas Multimídia e Web. Sociedade Brasileira de Computação - SBC, 2023. http://dx.doi.org/10.5753/webmedia_estendido.2023.234461.
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Suicide causes approximately 800,000 deaths worldwide every year, which means one death by suicide every 40 seconds. Suicidal ideation is the first stage in the suicide risk scale, in which the individuals have thoughts regarding being dead. Thereby, suicide prevention strategies may focus on identifying and treating individuals with this severity level. Therefore, this article presents the summary of an Academic Master’s Dissertation that proposes Thoth, a computational model for assisting people suffering from suicidal ideation. The main scientific contribution of the Thoth is the personalized assistance for individuals at risk of suicidal ideation through the analysis of Context Information for anticipating the identification of future risks. The model gathers sensor, sociodemographic, and psychological data for future risk checking through Machine Learning models. Experiments showed that the models obtained F1-Score up to 94.12%. Based on the experiments, Thoth could act in a personalized manner, sending recommendations and alerts to patients and caregivers, respectively. Thus, this research provides an improvement in the assistance of individuals with suicidal ideation through the proposed model.
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Saldanha, Mário, Marcelo Porto, César Marcon, and Luciano Agostini. "Time Reduction on 3D-HEVC Depth Maps Coding using Static Decision Trees Built Through Data Mining." In XXV Simpósio Brasileiro de Sistemas Multimídia e Web. Sociedade Brasileira de Computação - SBC, 2019. http://dx.doi.org/10.5753/webmedia_estendido.2019.8132.
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This dissertation presents a fast depth map coding for 3D-High Efficiency Video Coding (3D-HEVC) based on static Coding Unit (CU) splitting decision trees. The proposed solution is based on our previous works and avoids the costly Rate-Distortion Optimization (RDO) process for depth maps coding, which evaluates several possibilities of block partitioning and encoding modes for choosing the best one. This coding approach uses data mining and machine learning to extract the correlation among the encoder context attributes and to build the static decision trees. Each decision tree defines if a depth map CU must be split into smaller blocks, considering the encoding context through the evaluation of the CU features and encoder attributes. The results demonstrated that this approach can halve the 3D-HEVC encoder processing time with negligible coding efficiency loss. Besides, the obtained results surpass all related works regarding processing time and coding efficiency. The results reported in this dissertation were published in three journals and two events, besides generate a patent deposit. These products have the master student as the first author.
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Gillman, Sarah Kathleen. "SEISMIC STUDIES OF THE DEPTH EXTENT OF THE NORTH SISTER ANDESITE INTRUSION, WEST EL PASO, TEXAS." In GSA Annual Meeting in Indianapolis, Indiana, USA - 2018. Geological Society of America, 2018. http://dx.doi.org/10.1130/abs/2018am-321926.
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Vevere, Velga. "FEMINIST AUTOTHANATOGRAPHIES: ALICE JAMES AND SIMONE DE BEAUVOIR." In NORDSCI International Conference Proceedings. Saima Consult Ltd, 2019. http://dx.doi.org/10.32008/nordsci2019/b1/v2/34.
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Feminist autobiography is a genre with long-standing literary and philosophical tradition, still some aspects, like, autobiography as “death writing” have come to scholarly attention as of relatively recent. The conceptual framework hinged on the concepts of “tanatography” (defined as an account of a person’s death) and “autotanatography” (defined as an account of one’s own death) makes it possible to take a fresh look into feminist writings from 19th and 20th centuries (Alice James and Simone de Beauvoir). Among the questions for the critical reflection we can mention the following ones: issues of memory and forgetting, of death of the significant other, of aging, of suicide, of literary death (ending the writing career path). Autothanatography is self-death-writing, instead of self-life-writing, even if death is an experience that cannot be had for oneself. The current article takes a look into the auto-death-writing of two women writers: Alice James (1848-1892) – a sister of William and Henry James and Simone de Beauvoir (1908-1986). Although both women’s lives are set almost a century apart and none of them define herself as a feminist writer, their memoirs are written from the vantage point of imminent death. In the first case (James’s) we can speak of her posthumously published diaries, especially their second part written after she was diagnosed with breast cancer. Whereas in the latter (Beauvoir’s) case the autothanatological vibe is felt throughout the whole series of her memoirs (“Memoirs of a dutiful daughter”, “The prime of life”, “Force of circumstance”, “A very easy death”), but especially in the oeuvre “All is said and done” – the writing in anticipation of one’s death. The aspect that is common to both writers is that their memoirs exhibit the strategy of recollection, of re-reading their life events anew in the wake of the end (physical and/or authorial).
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Guiziou, Jean Luc, Patrick Compte, Patrice Guillaume, Berend C. Scheffers, Michel Riepen, and Tiny T. Van der Werff. "SISTRE: A time‐to‐depth conversion tool applied to structually complex 3‐D media." In SEG Technical Program Expanded Abstracts 1990. Society of Exploration Geophysicists, 1990. http://dx.doi.org/10.1190/1.1889970.
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Paula, Bruna C. M., Gabriel P. Oliveira, and Mirella M. Moro. "Mood Analysis during the COVID-19 Pandemic in Brazil through Music." In Simpósio Brasileiro de Sistemas Multimídia e Web. Sociedade Brasileira de Computação - SBC, 2022. http://dx.doi.org/10.5753/webmedia_estendido.2022.227063.
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In this paper, we investigate the oscillation in the general feelings of the Brazilian population during the Pandemic through the songs consumed. We analyze Brazilian streaming musical consumption between 2019 and 2021. In special, we focus on special dates that have changed history, such as the beginning of the pandemic in the country, the dates of increase in cases, milestone dates in deaths, the beginning of vaccination, among others. Data was collected through Spotify API and made publicly available. Our results show people have preferred more danceable and positive songs during the period analyzed.
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Meyer, João Vicente, Lucas Machado Palma, and Jean Everson Martina. "Document Validation using Blockchain: A validation scheme for natural persons documents." In XXXVIII Simpósio Brasileiro de Redes de Computadores e Sistemas Distribuídos. Sociedade Brasileira de Computação, 2020. http://dx.doi.org/10.5753/sbrc_estendido.2020.12426.
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The great extension of Brazil's territory, combined with its demographics of more than 200 million inhabitants, results in a complex, slow and expensive notary system. Blockchain technologies can be of huge help in this scenario. It provides a decentralized peer-to-peer way of storing and validating documents. In this article, we start the discussion about a blockchain-based national notary system with means to store and validate the natural person's public documents. We prototype a solution, comprising of birth, marriage, divorce, and death documents/certificates. In the end, we present a comparison between the operational costs of the implemented prototype and the current notary system.
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Batista, Matheus, Andréa Magdaleno, and Marcos Kalinowski. "A Survey on the use of Social BPM in Practice in Brazilian Organizations." In XIII Simpósio Brasileiro de Sistemas de Informação. Sociedade Brasileira de Computação, 2017. http://dx.doi.org/10.5753/sbsi.2017.6073.
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Social BPM is the combination of Business Process Management (BPM) with social and collaborative techniques for the purpose of exploring collaboration among stakeholders throughout the BPM lifecycle. Its goals are to reduce common problems in BPM by ensuring collaboration and transparency. To the best of our knowledge, there is no information on how Social BPM is being used in organizational environments and on its impacts. This study aims at showing how Brazilian organizations are using Social BPM practices and technologies. Therefore, a survey was conducted with employees from different companies in order to collect data on their usage of BPM collaborative practices. The survey received 31 replies and 3 of the respondents were also interviewed in order to provide depth to their answers and to enhance the overall understanding. The results show that collaboration happens predominantly in design, modeling, and improvement phases. Collaboration still happens mainly without formal planning and without tool support.
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Carbone, Martim d’Orey Posser de Andrade, and Paulo Lício de Geus. "Kernel Framework for an Immune-Based Security System: A Work-In-Progress Report." In Simpósio Brasileiro de Segurança da Informação e de Sistemas Computacionais. Sociedade Brasileira de Computação - SBC, 2005. http://dx.doi.org/10.5753/sbseg.2005.21547.
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This report informs on the current status of the project whose goal is to design, implement and integrate into the 2.6 version of the Linux kernel a generic framework to support a computer security system inspired in the principles of the human immune system. A brief introduction to the project is given, followed by a more in-depth discussion of the framework requirements and its overall architecture. It concludes by pointing out the future research and development stages.
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da Silva, Jaciana B., Jeferson G. de Freitas, José E. S. Moraes, et al. "APPonco - Um aplicativo móvel para acesso rápido e seguro à informação sobre o câncer infantojuvenil." In Anais Estendidos do Simpósio Brasileiro de Sistemas Multimídia e Web. Sociedade Brasileira de Computação - SBC, 2021. http://dx.doi.org/10.5753/webmedia_estendido.2021.17613.
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The Brazilian National Cancer Institute (INCA) estimates for each year of the 2020/2022 triennium 8,460 new cases of cancer in children and adolescents in the 1-19 age group. As the second cause of death in this age group in most regions of Brazil, childhood cancer is considered a serious public health problem. Fortunately, childhood cancer is a disease with a high probability of cure if diagnosed early and treated in specialized centers. Thus, early diagnosis is an important public health strategy for treatment and is directly related to patient survival. This paper presents APPonco, a mobile application for agile and safe access to information about childhood cancer for healthcare professionals (doctors, nurses, nutritionists, etc.) and the general public (patients, families and caregivers). APPonco was a demand from a reference center in the treatment of childhood cancer in Brazil. The paper details the requirements, architecture, and development process of the application. Since 2020, APPonco is available free for Android and iOS. The software is registered in the Brazilian National Institute of Industrial Property (INPI).
Relatórios de organizações sobre o assunto "Sisters – death"
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Sultana, Munawar. Two worlds under the same roof: A brief on gender difference in transitions to adulthood. Population Council, 2005. http://dx.doi.org/10.31899/pgy19.1008.
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Adolescence, a time of transition to adulthood, is different for young men and women in Pakistan; brothers and sisters living under the same roof have different opportunities available in all aspects of life. More young people aged 15–24 live in Pakistan now than at any other time in its history—an estimated 36 million in 2004. Recognizing the dearth of information on the situation of this large group of young people, the Population Council undertook a nationally representative survey from October 2001 to March 2002. The analysis presented in this brief comes from Adolescents and Youth in Pakistan 2001–02: A Nationally Representative Survey. The survey sought information from youth aged 15–24, responsible adults in the household, and other community members in 254 communities. A total of 6,585 households were visited and 8,074 young people were interviewed. This brief concludes that girls face disadvantages, especially in rural areas, and that parents, community, and policymakers need to work together to ensure that girls, like their brothers, are able to make a successful transition to adulthood.
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Study of Social Entrepreneurship and Innovation Ecosystems in the Latin American Pacific Alliance Countries: Case Study: Sistema Biobolsa, Mexico. Inter-American Development Bank, 2016. http://dx.doi.org/10.18235/0009332.
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This report sets out to present some of the highlights from a more in depth study carried out on social entrepreneurship and innovation ecosystems in Mexico, presenting the case study of Sistema Biobolsa. Sistema Biobolsa manufactures, installs and facilitates finance for high quality, affordable biodigester technologies, empowering farmers with long term sustainable resource management solutions.