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Livros sobre o tema "Signalling"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 6 de julho de 2024

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1

Telecommunications signalling. London: Institution of Electrical Engineers, 1999.

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2

Cell signalling. 3^a ed. Oxford: Oxford University Press, 2010.

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3

Cell signalling. 2^a ed. Oxford: Oxford University Press, 2005.

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4

Khan, Mohd Tanveer Alam, Mohammad Yusuf, Fariduddin Qazi e Aqeel Ahmad, eds. Brassinosteroids Signalling. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5743-6.

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5

Raffaello, Anna, e Denis Vecellio Reane, eds. Calcium Signalling. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9018-4.

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6

Kaestner, Lars. Calcium signalling. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34617-0.

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7

Hancock, John T. Cell signalling. 3^a ed. Oxford: Oxford University Press, 2010.

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8

Cell Signalling. London: Portland Press, 1998.

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9

1954-, Parker Peter J., e Pawson T, eds. Cell signalling. Plainview, NY: Cold Spring Harbor Laboratory Press, 1996.

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10

Cell signalling. Harlow: Longman, 1997.

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11

Hancock, John T. Cell signalling. 3^a ed. Oxford: Oxford University Press, 2010.

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12

Morgan, Noel G. Cell signalling. Milton Keynes [England]: Open University Press, 1989.

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13

Colin, Bailey, e Institution of Railway Signal Engineers., eds. European railway signalling. London: A & C Black, 1995.

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14

Dick, Knight, ed. Broadband signalling explained. Chichester: Wiley, 2000.

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15

Harvey, Amanda. Cancer cell signalling. Chichester, West Sussex: John Wiley & Sons, Inc., 2013.

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16

Nicholson, Sandra E., e Nicos A. Nicola, eds. JAK-STAT Signalling. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-242-1.

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17

Wang, Zhi-Yong, e Zhenbiao Yang, eds. Plant Signalling Networks. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-809-2.

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18

Knight, Dick, ed. Broadband Signalling Explained. Chichester, UK: John Wiley & Sons, Ltd, 2000. http://dx.doi.org/10.1002/0470841575.

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19

Drudi, Francesco. Signalling debt sustainability. London: Centre for Economic Policy Research, 1993.

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20

Engineers, Institution of Electrical, ed. Common-channel signalling. London, U.K: P. Peregrinus Ltd. on behalf of the Institution of Electrical Engineers, 1991.

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21

Nicholson, Mick. Semaphore signals: Constructing and operating. Nottingham: Booklaw Publications, 2004.

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22

Calcium signalling in cancer. Boca Raton: CRC, 2001.

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23

Batschauer, Alfred, ed. Photoreceptors and Light Signalling. Cambridge: Royal Society of Chemistry, 2007. http://dx.doi.org/10.1039/9781847551665.

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24

Dupont, Geneviève, Martin Falcke, Vivien Kirk e James Sneyd. Models of Calcium Signalling. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-29647-0.

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25

Carafoli, Ernesto, e Marisa Brini, eds. Calcium Signalling and Disease. Dordrecht: Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-6191-2.

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26

1922-, Reid Eric, Cook, G. M. W. 1938- e Luzio J. P, eds. Cell signalling: Experimental strategies. Cambridge: Royal Society of Chemistry, 1991.

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27

O, Pickens Charles, ed. Cell apoptotic signalling pathways. New York: Nova Biomedical Books, 2007.

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28

Horton, Mark. Step-by-step signalling. London: Batsford, 1994.

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29

Digby, Nigel. Signalling. Ian Allan Publishing, 2011.

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30

British Railway Signalling Practice - Signalling Instruments. Peter Kay, 2001.

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31

Hapke, Christian, e Hartmut Brandt. ATM Signalling. Wiley & Sons, Incorporated, John, 2000.

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32

Morgan, N. G. Cell Signalling. John Wiley and Sons Ltd, 1991.

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33

Morgan, Noel G. Cell Signalling. The Guilford Press, 1990.

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34

Cell Signalling. Oxford University Press, 2017.

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35

Hancock, John. Cell Signalling. Oxford University Press, 2021.

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36

Okkenhaug, Klaus, Martin Turner e Michael R. Gold, eds. PI3K signalling. Frontiers SA Media, 2015. http://dx.doi.org/10.3389/978-2-88919-419-3.

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37

Conn, P. Michael, e Saurabh Jha. Endosome Signalling. Elsevier Science & Technology Books, 2014.

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38

Taylor, Derek. Signalling Revenge. Lulu Press, Inc., 2012.

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39

Signalling Revenge. Lulu Press, Inc., 2013.

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40

Cell Signalling. John Wiley and Sons Ltd, 1991.

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41

Gasson, Harold. Signalling Days. OPC Railprint, 1989.

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42

Railway Signalling. A & C Black Publishers Ltd, 1993.

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43

Hancock, John. Cell Signalling. Prentice Hall, 1997.

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44

Conn, P. Michael, e Saurabh Jha. Endosome Signalling. Elsevier Science & Technology Books, 2014.

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45

Rath, Pramod C. Cell Signalling. Anshan Ltd, 2007.

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46

Costly signalling. London: Routledge, 2017.

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47

Allen, D., e Woostenholmes. Railway Signalling. Ian Allan Publishing Ltd, 1991.

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48

Signalling Success. National Institute of Adult Continuing Education, 2006.

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49

(Editor), Colin Bailey, ed. European Railway Signalling (Miscellaneous). A & C Black Publishers Ltd, 1995.

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50

Fleischmann, Roy. Signalling pathway inhibitors. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0081.

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Resumo:

Oral, small-molecule signalling pathway inhibitors, including ones that inhibit the JAK and SyK pathways, are currently in development for the treatment of rheumatoid arthritis (RA). Tofacitinib is an orally administered small-molecule inhibitor that targets the intracellular Janus kinase 3 and 1 (JAK1/3) molecules to a greater extent than JAK2 while baricitinib (formerly INCB028050) predominantly inhibits JAK1/2. Many of the proinflammatory cytokines implicated in the pathogenesis of RA utilize cell signalling that involves the JAK-STAT pathways and therefore inhibition of JAK-STAT signalling, by targeting multiple RA-associated cytokine pathways, has the potential to simultaneously reduce inflammation, cellular activation, and proliferation of key immune cells. Fostamatinib disodium is an orally available inhibitor of spleen tyrosine kinase (SyK), which is a cytoplasmic tyrosine kinase that is an important mediator of immunoreceptor signalling in mast cells, macrophages, neutrophils, and B cells. Interruption of SyK signalling may interrupt production of tumour necrosis factor (TNF) and metalloproteinase and therefore affect RA disease activity. Tofacitinib has been investigated in multiple phase 2 and phase 3 trials which have investigated its efficacy (clinical, functional, and radiographic) and safety in patients who have failed disease-modifying anti-inflammatory drugs (DMARDs) as monotherapy or in combination with DMARDs, compared to an inhibitor of tumour necrosis factor alpha (TNFα‎) and in patients who have failed TNFα‎ inhibitors. The efficacy of fostamatinib and baricitinib has been investigated in phase 2 trials; both are in large phase 3 clinical programmes. Each of these medications has demonstrated efficacy; their safety profile has been shown to be different from each other and from currently approved biological agents. This chapter discusses what is currently known and understood about their efficacy and safety.

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