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Saas, William J. "SFIC update". Metal Finishing 102, n.º 10 (outubro de 2004): 65. http://dx.doi.org/10.1016/s0026-0576(04)84663-4.
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Plassart, Mathilde, e Richard Shearmur. "SFIC et innovation : Les dynamiques géographiques de l'innovation à Québec". Canadian Geographer / Le Géographe canadien 58, n.º 2 (4 de março de 2014): 244–62. http://dx.doi.org/10.1111/cag.12068.
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Zou, Yangyuxin, Adam Frank, Zhuo Chen, Thomas Reichardt, Orsola De Marco, Eric G. Blackman, Jason Nordhaus et al. "Bipolar planetary nebulae from outflow collimation by common envelope evolution". Monthly Notices of the Royal Astronomical Society 497, n.º 3 (24 de julho de 2020): 2855–69. http://dx.doi.org/10.1093/mnras/staa2145.
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ABSTRACT The morphology of bipolar planetary nebulae (PNe) can be attributed to interactions between a fast wind from the central engine and the dense toroidal-shaped ejecta left over from common envelope (CE) evolution. Here we use the 3D hydrodynamic adaptive mesh refinement (AMR) code AstroBEAR to study the possibility that bipolar PN outflows can emerge collimated even from an uncollimated spherical wind in the aftermath of a CE event. The output of a single CE simulation via the smoothed particle hydrodynamics (SPH) code phantom serves as the initial conditions. Four cases of winds, all with high enough momenta to account for observed high momenta pre-PN outflows, are injected spherically from the region of the CE binary remnant into the ejecta. We compare cases with two different momenta and cases with no radiative cooling versus application of optically thin emission via a cooling curve to the outflow. Our simulations show that in all cases highly collimated bipolar outflows result from deflection of the spherical wind via the interaction with the CE ejecta. Significant asymmetries between the top and bottom lobes are seen in all cases. The asymmetry is strongest for the lower momentum case with radiative cooling. While real post-CE winds may be aspherical, our models show that collimation via ‘inertial confinement’ will be strong enough to create jet-like outflows even beginning with maximally uncollimated drivers. Our simulations reveal detailed shock structures in the shock-focused inertial confinement (SFIC) model and develop a lens-shaped inner shock that is a new feature of SFIC-driven bipolar lobes.
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Zhou, Cuifang. "A Dual Collaborative Governance based on SFIC Model: a Case Study of the Chinese Film and Television Industry". BCP Business & Management 26 (19 de setembro de 2022): 431–36. http://dx.doi.org/10.54691/bcpbm.v26i.1993.
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The Chinese film and television industry is witnessing the changing relationships of its governance between government and other stakeholders. Understanding the stakeholders and their interactions is critical to an improvement in the performance of collaborative governance regimes. This paper proposes an institutional framework which emphasizes the important role of industry associations as an aid to the government in terms of improving media governance performance. Based on the SFIC collaborative model, we develop a model for a better media governance in the Chinese film and television industry with a design of the five dimensions: starting conditions, catalytic leadership, system design, synergistic process and synergistic effect. By analyzing the governance patterns in the Chinese film and television industry, this paper provides valuable insights into the regulations on Chinese media industries.
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李, 玉冰. "Research on Collaborative Provision of Home-Based Community Care for the Elderly Based on SFIC". Aging Research 10, n.º 04 (2023): 1410–16. http://dx.doi.org/10.12677/ar.2023.104184.
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Boulland, Paul, e Julian Mischi. "« Une nécessaire opération de reclassement ». Sociobiographie du Comité directeur de la SFIC (1920-1925)". Le Mouvement Social 272, n.º 3 (2020): 17. http://dx.doi.org/10.3917/lms.272.0017.
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KOKUBU, Takao, Kenzou KAMIYAMA e Junichi HAMANO. "Application of Sequential Function Chart to the Tire Industry". Transactions of the Society of Instrument and Control Engineers 30, n.º 7 (1994): 853–60. http://dx.doi.org/10.9746/sicetr1965.30.853.
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Maguin, E., H. Brody, C. W. Hill e R. D'Ari. "SOS-associated division inhibition gene sfiC is part of excisable element e14 in Escherichia coli." Journal of Bacteriology 168, n.º 1 (1986): 464–66. http://dx.doi.org/10.1128/jb.168.1.464-466.1986.
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Czapliński, Mariusz, Paweł Sokólski, Kazimierz Duzinkiewicz, Robert Piotrowski e Tomasz Rutkowski. "Comparison of state feedback and PID control of pressurizer water level in nuclear power plant". Archives of Control Sciences 23, n.º 4 (1 de dezembro de 2013): 455–71. http://dx.doi.org/10.2478/acsc-2013-0028.
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Abstract The pressurizer water level control system in nuclear power plant with pressurized water reactor (PWR) is responsible for coolant mass balance. The main control goal is to stabilize the water level at a reference value and to suppress the effect of time-varying disturbances (e.g. coolant leakage in primary circuit pipeline system). In the process of PWR power plant operation incorrect water level may disturb pressure control or may cause damage to electric heaters which could threaten plant security and stability. In modern reactors standard PID controllers are used to control water level in a pressurizer. This paper describes the performance of state feedback integral controller (SFIC) with reduced-order Luenberger state observer designed for water level control in a pressurizer and compares it to the standard PID controller. All steps from modeling of a pressurizer through control design to implementation and simulation testing in Matlab/Simulink environment are detailed in the paper.
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Carrincazeaux, Christophe, David Doloreux e Richard Shearmur. "Une analyse régionale comparative de la géographie de l'innovation : le cas des Sfic en France et au Canada". Revue d’Économie Régionale & Urbaine Décmbr, n.º 5 (2016): 1043. http://dx.doi.org/10.3917/reru.165.1043.
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Ju, Jin-yong, Wei Li, Yufei Liu e Chunrui Zhang. "Master-Slave Integrated Control for the Transverse Vibration of a Translational Flexible Manipulator Based on Input Shaping and State Feedback". Shock and Vibration 2019 (4 de junho de 2019): 1–13. http://dx.doi.org/10.1155/2019/8419591.
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The problem of the elastic vibration control for a translational flexible manipulator system (TFMS) under variable load conditions is studied. The input shaper can effectively filter out the vibration excitation components for the flexible manipulator in the driving signals, but the adaptability and rapidity of the conventional input shaper are poor because it is essentially an open-loop control mode and there are time-lag links inevitably. Thus, by combining the state feedback with the input shaping, a master-slave integrated controller of the TFMS is proposed. Moreover, in order to solve the time-lag effect of the conventional input shaper, based on the optimal algorithm, a two-mode vibration cascade shaper for the TFMS is designed. Then, under variable load conditions, the control effects of the conventional input shapers, the two-mode vibration cascade shaper, and the combination of the state feedback integral controller (SFIC) with the above shapers are investigated. The results show that the designed master-slave integrated controller has high robustness under variable load conditions and takes good account of the requirements of system response time and overshoot for achieving the goal of nonovershoot under fast response speed. Simulation experiment results verify the effectiveness of the designed controller.
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Xu, Zhu, e Li Jiaqi. "Global collaborative implementation of Kunming-Montreal Global Biodiversity Framework: An analysis of challenge and solutions based on the SFIC model". Biodiversity Science 31, n.º 8 (2023): 23167. http://dx.doi.org/10.17520/biods.2023167.
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Mathorne, Ole, Natalia Stambulova, Rob Book, Louise Kamuk Storm e Kristoffer Henriksen. "Shared Features of Successful Interorganizational Collaboration to Promote Local Talent Development Environments in Denmark". Scandinavian Journal of Sport and Exercise Psychology 3 (25 de abril de 2021): 2–12. http://dx.doi.org/10.7146/sjsep.v3i.121379.
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The aim of this study was to explore 11 case examples of successful talent development collaborations between sport federations, municipalities, and local clubs in Denmark in order to identify potential shared features of successful collaborations. We hypothesized that each case example would be unique, but that they would also share features that could be organized to provide practitioners with a model to guide the improvement of their practice. Grounded in the holistic ecological approach, the study was designed as a multiple case study to facilitate a cross-case analysis. Three Danish sport federations (handball, ice hockey, and swimming), nine municipalities, and eleven local clubs participated in the study, and the data was generated from 23 semi-structured interviews with stakeholders. Analysis led to the construction of six shared features of successful interorganizational collaboration organized into: (1) a list of features (SFIC-TD) with positive and opposite pole descriptors and three categories: collaborative philosophy, collaborative decisions, and collaborative actions, and (2) an applied framework termed the pyramid model for optimization of interorganizational collaboration in talent development (PIC-TD) which illustrates how the abovementioned categories lead to collaborative outcomes. Developing a shared philosophy of talent development was found to be a foundational starting point for successful collaboration between relevant organizations on the micro- and macro-level to improve the local athletic talent development environment.
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Oliazadeh, S., M. R. Khoram e M. Abbasi. "Design and development of a web GIS for management and performance evaluation of agricultural farms of sahar food industries company (SFIC)". Journal of Physics: Conference Series 1918, n.º 4 (1 de junho de 2021): 042017. http://dx.doi.org/10.1088/1742-6596/1918/4/042017.
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Chung, Lee, Cho, Park, Baik, Lee e Kang. "Changes in Body Composition During Adjuvant FOLFOX Chemotherapy and Overall Survival in Non-Metastatic Colon Cancer". Cancers 12, n.º 1 (24 de dezembro de 2019): 60. http://dx.doi.org/10.3390/cancers12010060.
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The impact of longitudinal anthropometric changes during adjuvant chemotherapy on long-term survival in non-metastatic colon cancer is unclear. Herein, we analyzed the prognostic significance of computed tomography (CT)-measured body composition changes in colon cancer patients who underwent surgery followed by adjuvant FOLFOX (folinic acid, 5-fluorouracil, oxaliplatin) chemotherapy. Data of 167 patients with stage III or high-risk stage II colon cancer were analyzed. Skeletal muscle index (SMI), skeletal muscle radiodensity (SMR), visceral fat index (VFI), subcutaneous fat index (SFI), and total fat index (TFI) changes during chemotherapy were calculated using preoperative and postchemotherapy CT image data. The Cox proportional hazard model was used to determine the correlation between changes in anthropometric values and overall survival (OS). The median changes (%) in SMI, SMR, VFI, SFI, and TFI over 210 days during chemotherapy were 8.7% (p < 0.001), 3.4% (p = 0.001), −19% (p < 0.001), −3.4% (p = 0.936), and −11.9% (p < 0.001), respectively. Cut-off values of changes in SMI (skeletal muscle index change, SMIC) and SMR (skeletal muscle radiodensity change, SMRC) were defined at −2% and −2 Hounsfield units (HU) respectively, whereas those of changes in VFI (visceral fat index change, VFIC), SFI (subcutaneous fat index change, SFIC), and TFI (total fat index change, TFIC) were based on values that provided the largest χ2 on the Mantel–Cox test. Multivariable analysis revealed that low SMR measured on a postchemotherapy CT scan (hazard ratio, HR: 0.32, 95% confidence interval, CI: 0.15–0.70, p = 0.004) and visceral fat loss of at least 46.57% (HR: 0.31, 95% CI: 0.14–0.69, p = 0.004) were independent poor prognostic factors for OS. Severe visceral fat loss during FOLFOX chemotherapy and low skeletal muscle radiodensity measured on postchemotherapy CT scans are associated with poor OS in stage III and high-risk stage II colon cancer patients.
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Flores, A., e J. Casadesús. "Suppression of the pleiotropic effects of HisH and HisF overproduction identifies four novel loci on the Salmonella typhimurium chromosome: osmH, sfiW, sfiX, and sfiY." Journal of bacteriology 177, n.º 17 (1995): 4841–50. http://dx.doi.org/10.1128/jb.177.17.4841-4850.1995.
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Phan, Hoang Cong, Thang Thanh Phan, Toan Trong Ho, Thu Bich Tran, Thanh Thanh MCB e Son Truong Nguyen. "ID: 1075 Concentration and κ/λ ratio of serum free light chain in multiple myeloma patients at Cho Ray Hospital". Biomedical Research and Therapy 4, S (5 de setembro de 2017): 159. http://dx.doi.org/10.15419/bmrat.v4is.349.
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Introduction: multiple myeloma (MM) is a B cell malignancy which characterized by accumulation of plasmocyte in bone marrow, immunoglobulins and free light chain in serum (sFLC). According to IMMWG (International multiple myeloma working group), sFLC is a criterion in diagnosis of MM. In this study, we investigate the concentration and κ/λ ratio of sFLC in newly diagnosed MM patients at Cho Ray hospital. Methods: cross-sectional study. Serum samples of 36 newly diagnosed MM patients were analyzed by Binding Site Freelite method to measure the amount of κ and λ sFLC.
Results: the median age of 36 MM patients was 61 yrs (41 – 88 yrs), with the male/female ratio was 1.2/1. MM stage III, stage II and stage I accounting for 63.9% (23/36), 27.8% (10/36), and 8.3% (3/36), respectively. Clonal IgG, IgA and IgE MM accounting for 61.1% (22/36), 30.6% (11/36), and 8.3% (3/36), respectively. We reported the median of plasmocyte in 36 cases was 35.4% (95%CI: 27.6 – 43.3). The median of concentration of κ sFLC, λ sFLC, and involved/uninvolved sFLC ratio were 1601.8 mg/L (95%CI: 104.9 – 3098.7), 900.1 mg/L (95%CI: 10.7 – 1789.5), and 191.0 (95%CI: 87.6 – 294.4), respectively. The abnormally high in sFLC concentration was reported in 97.2% MM cases (35/36), in which 55.6% cases (20/36) had increased κ sFLC, 19.4% cases (7/36) had increased λ sFLC, and 22.2% cases (8/36) had increased both κ+λ sFLC concentration. Increased involved/uninvolved sFLC ratio was found in 94.4% MM cases (34/36), in which 36.1% cases (13/36) had sFLC ratio > 100, with all involved sFLC concentration > 100 mg/L. In 3 cases of MM with kidney failure, 2 cases had increased both κ+λ sFLC, 1 case had increased κ sFLC concentration; and all of 3 cases had involved sFLC level > 5300 mg/L with sFLC ratio > 100. No significant difference of sFLC concentration and sFLC ratio among gender, stage of disease, Ig clone, or plasmocyte percent in bone marrow of MM patients. Conclusions: due to the abnormally high of sFLC concentration and sFLC ratio in MM, it is necessary to monitor frequently these parameters during treatment to prevent the risk of kidney failure for patients.
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Clavijo, Gabriel, Trevor Williams, Oihane Simón, Delia Muñoz, Martine Cerutti, Miguel López-Ferber e Primitivo Caballero. "Mixtures of Complete and pif1- and pif2-Deficient Genotypes Are Required for Increased Potency of an Insect Nucleopolyhedrovirus". Journal of Virology 83, n.º 10 (4 de março de 2009): 5127–36. http://dx.doi.org/10.1128/jvi.02020-08.
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ABSTRACT The insecticidal potency of a nucleopolyhedrovirus population (SfNIC) that infects Spodoptera frugiperda (Lepidoptera) is greater than the potency of any of the component genotypes alone. Occlusion bodies (OBs) produced in mixed infections comprising the complete genotype and a deletion genotype are as pathogenic as the natural population of genotypes from the field. To test whether this increased potency was due to the deletion or to some other characteristic of the deletion variant genome, we used the SfNIC-B genome to construct a recombinant virus (SfNIC-BΔ16K) with the same 16.4-kb deletion as that observed in SfNIC-C and another recombinant (SfNIC-BΔpifs) with a deletion encompassing two adjacent genes (pif1 and pif2) that are essential for transmission per os. Mixtures comprising SfNIC-B and SfNIC-BΔ16K in OB ratios that varied between 10:90 and 90:10 were injected into insects, and the progeny OBs were fed to larvae in an insecticidal potency assay. A densitometric analysis of PCR products indicated that SfNIC-B was generally more abundant than expected in mixtures based on the proportions of OBs used to produce the inocula. Mixtures derived from OB ratios of 10, 25, or 50% of SfNIC-BΔ16K and the corresponding SfNIC-B proportions showed a significant increase in potency compared to SfNIC-B alone. The results of potency assays with mixtures comprising various proportions of SfNIC-B plus SfNIC-BΔpifs were almost identical to the results observed with SfNIC-BΔ16K, indicating that deletion of the pif gene region was responsible for the increased potency observed in mixtures of SfNIC-B and each deletion recombinant virus. Subsequently, mixtures produced from OB ratios involving 10 or 90% of SfNIC-BΔ16K with the corresponding proportions of SfNIC-B were subjected to four rounds of per os transmission in larvae. The composition of each experimental mixture rapidly converged to a common equilibrium with a genotypic composition of ∼85% SfNIC-B plus ∼15% SfNIC-BΔ16K. Nearly identical results were observed in peroral-passage experiments involving mixtures of SfNIC-B plus SfNIC-BΔpifs. We conclude that (i) the deletion of the pif1 and pif2 region is necessary and sufficient to explain the increased potency observed in mixtures of complete and deletion genotypes and (ii) viral populations with decreased ratios of pif1- and pif2-deficient genotypes in the virus population increase the potency of genotypic mixtures and are likely to positively influence the transmission of this pathogen.
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Hong, Pan, Xiaojian Meng, Jingsong He, Wenjun Wu, Yi Li, Xiaoyan Han, Gaofeng Zheng et al. "Clinical Significance of Serum Free Light Chain Test in the First Onset of Multiple Myeloma". Blood 120, n.º 21 (16 de novembro de 2012): 4999. http://dx.doi.org/10.1182/blood.v120.21.4999.4999.
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Abstract Abstract 4999 Objective: Clinical significance of serum free light chain (sFLC) test in the diagnosis, efficacy evaluation, prognosis judgment of first onset of multiple myeloma (MM). Method: Medical records of 39 cases of first-onset MM were gathered in our hospital from 1/2010 to 2/2012, including 25 male and 14 female patients with the median age being 63 years old. sFLC-kappa and sFLC-lambda were determined by immune turbidimetric assay, sFLC-kappa/lambda were calculated and the results were compared with that of immunofixation electrophoresis (IFE) as well as serum protein electrophoresis (SPE) for sensitivity assessment. All patients were treated with chemotherapy followed by sFLC detection and efficacy assessment. Patients with a sFLC results higher than median were marked as high-sFLC, the rest were marked as low-sFLC, and survival analysis were made comparing the two groups. Results: Of the 39 first-onset MM patients, 38 were detected as sFLC- kappa/lambda positive, that's a sensitivity of 97. 4%, higher than IFE (79. 5%), SPE (53. 8%), and uPE (38. 5%). As condition improves after treatment, sFLC gradually decline and sFLC- kappa/lambda level falls back to normal. Evaluation of efficacy by sFLC results has an accuracy of 77. 27%, significantly higher than that of corresponding M protein test£̈ P=0. 009£©. Follow-up survival analysis showed that the OS time and TTP time of low-sFLC group are significantly higher than those of high-sFLC group (P=0. 037, 0. 009 respectively). Conclusion: sFLC detection is a highly sensitive quantitative method, can help the diagnosis of MM, gives a quicker assessment of treatment efficacy, and can predict disease recurrence. When it's the first onset, sFLC level can also roughly forecast the prognosis. Disclosures: No relevant conflicts of interest to declare.
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Lee, I.-Ju, Ning Wang, Wen Hu, Kersey Schott, Jürg Bähler, Thomas H. Giddings, John R. Pringle, Li-Lin Du e Jian-Qiu Wu. "Regulation of spindle pole body assembly and cytokinesis by the centrin-binding protein Sfi1 in fission yeast". Molecular Biology of the Cell 25, n.º 18 (15 de setembro de 2014): 2735–49. http://dx.doi.org/10.1091/mbc.e13-11-0699.
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Centrosomes play critical roles in the cell division cycle and ciliogenesis. Sfi1 is a centrin-binding protein conserved from yeast to humans. Budding yeast Sfi1 is essential for the initiation of spindle pole body (SPB; yeast centrosome) duplication. However, the recruitment and partitioning of Sfi1 to centrosomal structures have never been fully investigated in any organism, and the presumed importance of the conserved tryptophans in the internal repeats of Sfi1 remains untested. Here we report that in fission yeast, instead of doubling abruptly at the initiation of SPB duplication and remaining at a constant level thereafter, Sfi1 is gradually recruited to SPBs throughout the cell cycle. Like an sfi1Δ mutant, a Trp-to-Arg mutant (sfi1-M46) forms monopolar spindles and exhibits mitosis and cytokinesis defects. Sfi1-M46 protein associates preferentially with one of the two daughter SPBs during mitosis, resulting in a failure of new SPB assembly in the SPB receiving insufficient Sfi1. Although all five conserved tryptophans tested are involved in Sfi1 partitioning, the importance of the individual repeats in Sfi1 differs. In summary, our results reveal a link between the conserved tryptophans and Sfi1 partitioning and suggest a revision of the model for SPB assembly.
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Jia, Yan Dong, Zheng Wei Zhou, Yan Dong Qu e Ao Shuang Tian. "Experimental Research on the Fracture Properties of Roller Compacted Steel Fiber Recycled Concrete". Advanced Materials Research 299-300 (julho de 2011): 135–38. http://dx.doi.org/10.4028/www.scientific.net/amr.299-300.135.
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Comparative experiments on the ordinary steel fiber recycled concrete (SFRC) and roller compacted SFRC were carried out to research the fracture properties of roller compacted SFRC. The results show that compressive strength, fracture toughness and fracture energy of roller compacted SFRC increase with the increase of fiber volume fraction. Compressive strength increase with the increase of recycled aggregate replacement rate and fracture toughness decrease, however, Crack tip opening displacement has little changes and fracture energy features fluctuation with the replacement ratio of recycled coarse aggregates increasing. The rolled formed layers have significant influence on the fracture properties of SFRC. The fracture toughness of roller compacted SFRC is generally lower than ordinary SFRC and compressive strength is higher than ordinary steel fiber concrete for the same aggregate replacement ratio and fiber volume fraction. Fracture energy of roller compacted SFRC is higher than ordinary SFRC for the higher steel fiber volume ratio.
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Rüthnick, Diana, e Elmar Schiebel. "Duplication of the Yeast Spindle Pole Body Once per Cell Cycle". Molecular and Cellular Biology 36, n.º 9 (7 de março de 2016): 1324–31. http://dx.doi.org/10.1128/mcb.00048-16.
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The yeast spindle pole body (SPB) is the functional equivalent of the mammalian centrosome. Centrosomes and SPBs duplicate exactly once per cell cycle by mechanisms that use the mother structure as a platform for the assembly of the daughter. The conserved Sfi1 and centrin proteins are essential components of the SPB duplication process. Sfi1 is an elongated molecule that has, in its center, 20 to 23 binding sites for the Ca2+-binding protein centrin. In the yeastSaccharomyces cerevisiae, all Sfi1 N termini are in contact with the mother SPB whereas the free C termini are distal to it. During S phase and early mitosis, cyclin-dependent kinase 1 (Cdk1) phosphorylation of mainly serine residues in the Sfi1 C termini blocks the initiation of SPB duplication (“off” state). Upon anaphase onset, the phosphatase Cdc14 dephosphorylates Sfi1 (“on” state) to promote antiparallel and shifted incorporation of cytoplasmic Sfi1 molecules into the half-bridge layer, which thereby elongates into the bridge. The Sfi1 C termini of the two Sfi1 layers localize in the bridge center, whereas the N termini of the newly assembled Sfi1 molecules are distal to the mother SPB. These free Sfi1 N termini then assemble the new SPB in G1phase. Recruitment of Sfi1 molecules into the anaphase SPB and bridge formation were also observed inSchizosaccharomyces pombe, suggesting that the Sfi1 bridge cycle is conserved between the two organisms. Thus, restricting SPB duplication to one event per cell cycle requires only an oscillation between Cdk1 kinase and Cdc14 phosphatase activities. This clockwork regulates the “on”/“off” state of the Sfi1-centrin receiver.
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Le, Anh Thang, Manh Tuan Nguyen e Van Phuc Le. "The Effect of Spent Fluid Catalytic Cracking Filler on Performance Testing of Asphalt Concrete Mixture". Advances in Materials Science and Engineering 2021 (31 de julho de 2021): 1–17. http://dx.doi.org/10.1155/2021/8577021.
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The spent fluid catalytic cracking (SFCC), waste from the petroleum industry, is nonstop increasing and causing environmental pollution in Vietnam. This study is an attempt to recycle SFCC in pavement construction. The study investigated the effect of SFCC, as a filler material in the hot-mix asphalt (HMA), on the essential characteristics of the asphalt concrete mix. First, the optimum percentages of bitumen and SFCC rate were investigated based on the Marshall design method. The HMA with SFCC showed more enhanced stability, flow, and other Marshall properties than the asphalt concrete mixture with the optimum limestone filler of 5%. Besides, the effects of SFCC rates on Marshall characteristics were explored. Second, performance tests were conducted to compare the mix with the different optimum content fillers of SFCC, limestone, and Portland cement. The tests include wheel tracking, indirect tensile, fatigue, and dynamic modulus tests to evaluate the performance of HMA with SFCC. It was found that the asphalt mixture with the optimum SFCC filler content can enhance pavement performance and improve the rutting and cracking resistance of the asphalt pavement.
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Seybold, Christian, Menattallah Elserafy, Diana Rüthnick, Musa Ozboyaci, Annett Neuner, Benjamin Flottmann, Mike Heilemann, Rebecca C. Wade e Elmar Schiebel. "Kar1 binding to Sfi1 C-terminal regions anchors the SPB bridge to the nuclear envelope". Journal of Cell Biology 209, n.º 6 (15 de junho de 2015): 843–61. http://dx.doi.org/10.1083/jcb.201412050.
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The yeast spindle pole body (SPB) is the functional equivalent of the mammalian centrosome. The half bridge is a SPB substructure on the nuclear envelope (NE), playing a key role in SPB duplication. Its cytoplasmic components are the membrane-anchored Kar1, the yeast centrin Cdc31, and the Cdc31-binding protein Sfi1. In G1, the half bridge expands into the bridge through Sfi1 C-terminal (Sfi1-CT) dimerization, the licensing step for SPB duplication. We exploited photo-activated localization microscopy (PALM) to show that Kar1 localizes in the bridge center. Binding assays revealed direct interaction between Kar1 and C-terminal Sfi1 fragments. kar1Δ cells whose viability was maintained by the dominant CDC31-16 showed an arched bridge, indicating Kar1’s function in tethering Sfi1 to the NE. Cdc31-16 enhanced Cdc31–Cdc31 interactions between Sfi1–Cdc31 layers, as suggested by binding free energy calculations. In our model, Kar1 binding is restricted to Sfi1-CT and Sfi1 C-terminal centrin-binding repeats, and centrin and Kar1 provide cross-links, while Sfi1-CT stabilizes the bridge and ensures timely SPB separation.
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DIGAMBAR PATIL, BHUPESH, SOPAN NAMDEV NANGARE e LAXMIKANT RAMVALLABH ZAWAR. "PREPARATION OF CRYSTALLINITY TAILORED SILK FIBROIN-SODIUM ALGINATE BASED FLOATING MICROBEADS FOR NEVIRAPINE DELIVERY". Cellulose Chemistry and Technology 57, n.º 5-6 (20 de julho de 2023): 527–39. http://dx.doi.org/10.35812/cellulosechemtechnol.2023.57.47.
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The present work anticipated crystallinity-tuned silk fibroin (SFIB)-sodium alginate floating microbeads (MB) as a candidate for nevirapine (NEV) sustained release. Briefly, crystallinity tuning was accomplished using solvent annealing. The changes in structural conformation of SFIB were validated using FTIR spectroscopy. Here, the tangent baseline method revealed changes in crystallinity of floating NEV-loaded SFIB-MB. Importantly, solvent annealing offers conversion of amorphous ‘α-helix’ to crystalline ‘β-sheet’ of SFIB, helping to modify drug release from the matrix of SFIB-sodium alginate. As well, NEV-loaded SFIB-MB demonstrated good floating profile. The NEV-loaded SFIB-MB with ethanol (ETH-6) annealing for 6 hours shows 25.853% drug release at 12 hours (pH = 1.2), compared to untreated NEV-loaded SFIB-MB (65.132%, 12 hours, log p < 0.0001). The release kinetics of batch ETH-6 revealed first-order release kinetics and Fickian diffusion (n = 0.468) was found to be the drug diffusion mechanism. Therefore, crystallinity-modified floating NEV-loaded SFIB-based MB will open a new door for modified drug delivery.
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Atika, Amelia, e Hastiani Hastiani. "Penerapan Solution-Focus Brief Counseling (SFBC) Untuk Meningkatkan Kemampuan Kerjasama Pada Mahasiswa". Nusantara of Research : Jurnal Hasil-hasil Penelitian Universitas Nusantara PGRI Kediri 9, n.º 2 (31 de julho de 2022): 125–36. http://dx.doi.org/10.29407/nor.v9i2.16611.
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Tujuan penelitian yaitu menghasilkan panduan solution focus brief counseling (SFBC) untuk meningkatkan kemampuan kerja sama mahasiswa bimbingan dan konseling. Fokus masalah dalam penelitian ini adalah meningkatkan kemampuan kerjasama mahasiswa IKIP-PGRI Pontianak. Pendekatan menggunakan Penelitian Tindakan Kelas (PTK) melalui dua siklus. Penilaian aspek kerjasama mahasiswa dalam penerapan panduan SFBC untuk meningkatkan kemampuan kerjasama mahasiswa. Penilaian aspek kerjasama mahasiswa dalam dalam penerapan panduan SFBC menggunakan pedoman observasi adapun indikator mencangkup komunikasi, koordinasi, kontribusi, toleransi, tanggung jawab, dan motivasi. Hasil penelitian menunjukkan bahwa panduan SFBC dapat meningkatkan keterampilan kerjasama mahasiswa. Adapun perolehan indikator kerjasama pada setiap siklus tergolong “Baik” dan “Sangat Baik”, untuk perolehan rerata setiap siklus. Panduan SFBC untuk meningkatkan kemampuan kerjasama mahasiswa, yang terdiri dari: Rasional, tujuan pelaksanaan, pelaksanaan, teknik-teknik terapi SFBC, evaluasi, dan tindak lanjut. Setelah penerapan panduan SFBC maka dapat disimpulkan bahwa panduan SFBC dapat digunakan untuk meningkatkan kemampuan kerjasama mahasiswa.
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Allen, S., E. Vickrey, J. Mehta e S. Singhal. "The Relationship Between Serum Free Light Chain Levels and Serum Immunofixation Electrophoresis: Implications for the Definition of “Stringent CR” in Myeloma". Blood 112, n.º 11 (16 de novembro de 2008): 2724. http://dx.doi.org/10.1182/blood.v112.11.2724.2724.
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Abstract The serum free light chain (SFLC) assay enables detection of an abnormal protein in patients with plasma cell dyscrasias who secrete no or small quantities of monoclonal protein in the serum. Thus, the SFLC ratio may be abnormal (normal range; 0.26–1.65) in patients who have no M protein on serum immunofixation electrophoresis (SIFE). However, the relationship between the SFLC ratio and abnormal SIFE in patients who do secrete detectable M protein has not been studied. The new international response criteria for myeloma define an entity called stringent complete remission (CR) based on negative SIFE and normal SFLC ratio (with absent clonal plasmacytosis). “CR” is distinguished from “stringent CR” by lack of requirement of normal SFLC ratio in these new criteria. The old criteria did not use SFLC. The new criteria have not been validated prospectively whereas the old criteria have been used in multiple clinical trials. The obvious implication of using normalization of SFLC ratio to define “stringent CR” is that the SFLC ratio is the most sensitive indicator of residual disease. Thus, one would expect to see abnormal SFLC ratio when SIFE is normal but not vice versa. We explored the relationship between SIFE and SFLC ratio in 122 patients with secretory IgG or IgA myeloma. 2648 samples through the continuum of therapy that fulfilled the following criteria were studied: availability of concomitant SFLC and SIFE, and lack of oligoclonal bands on SIFE and UIFE. SIFE showed the original M protein in 2342 samples (88%). SFLC ratio was normal (0.26–1.65) in 1012 (38%). The abnormal ratio was concordant in 1536 and discordant in 100. SFLC ratios were considered concordant if <0.26 for lambda disease and >1.65 for kappa disease, and discordant if <0.26 for kappa disease and >1.65 for lambda disease. Discordant ratios were grouped with normal because they did not reflect an excess of the abnormal light chain associated with the original M protein. If the 95% CI values for SFLC ratio were used (0.3–1.2), 810 (31%) results were normal. With the 95% CI values, the abnormal ratio was concordant in 1702 and discordant in 136. The SFLC ratio was normal in 34% of cases with positive SIFE and abnormal in 66%. On the contrary, the SFLC ratio was normal in 69% of cases with negative SIFE and abnormal in 31%. As the table below shows, the proportion of cases with positive SIFE and normal SFLC ratio was much higher than those with an abnormal SFLC ratio and negative SIFE. SIFE SFLC ratio SFLC ratio Normal Abnormal Normal or discordant abnormal Concordant abnormal Positive 802 (30%) 1540 (58%) 874 (33%) 1468 (55%) Negative 210 (8%) 96 (4%) 238 (9%) 68 (3%) SIFE is currently considered to be the standard indicator of the presence of an M protein. When evaluated against that, the sensitivity of SFLC is 66% and its specificity is 69%. The sensitivity drops to 63% but specificity improves to 77% if discordant abnormal ratios are considered normal. What if either positive SIFE or a concordant abnormal SFLC ratio were considered to indicate residual disease (2410; 91%) and a negative SIFE as well as a normal or discordant abnormal SFLC ratio were required to rule out residual M protein (238; 9%)? In this case, the sensitivity of SIFE is 97% and that of an abnormal concordant SFLC ratio 62%. The assumptions do not allow calculation of specificity. Our data indicate that a normal SFLC ratio cannot rule out the presence of residual disease as conventionally defined by a positive SIFE, and that a normal SFLC ratio is significantly more likely to be seen in the presence of a positive SIFE than is a negative SIFE in the presence of an abnormal SFLC ratio. Additional prospective work is required before SFLC estimation and ratio can be incorporated into assessment of response in myeloma, and to see if the “stringent CR” entity truly defines a more robust disease response than “non-stringent CR.”
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Lim, Won Gyun, Su Won Kang e Hyun Do Yun. "Shear Behavior of Squat Steel Fiber Reinforced Concrete (SFRC) Shear Walls with Vertical Slits". Applied Mechanics and Materials 372 (agosto de 2013): 207–10. http://dx.doi.org/10.4028/www.scientific.net/amm.372.207.
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Three 1/3-scale squat steel fiber reinforced concrete (SFRC) shear walls with height-to-length ratio of 0.55 were manufactured and tested up to failure. Two walls (SFRC-SS and-LS) are similar to each other except the height (230 and 460mm) of vertical slits with the width of 40mm. For comparison, solid wall (SFRC-NS) was made. All specimens had the same rectangular cross-section of 1,100mm x 50mm, with wall panel height of 600mm. The experimental results showed that squat SFRC shear walls with vertical slits exhibited more stable hysteretic behavior than a solid SFRC shear wall. Vertical slits on the squat SFRC shear walls improve the ductility and energy dissipation capacity but decrease the load-carrying capacity and stiffness of squat SFRC walls.
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Ráček, Václav, e Jan Vodička. "Technology of Production of SFRC at Concrete Plants". Advanced Materials Research 1000 (agosto de 2014): 273–76. http://dx.doi.org/10.4028/www.scientific.net/amr.1000.273.
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Currently, manufacture of steel fibre reinforced concrete (SFRC) takes place in concrete mixer truck for floors mostly of industrial halls. This technology is suitable for low dosages of fibres (about 20kg/m3), which is determined by uncrossable price of deposited concrete (400 – 600 crowns/m2 for the floor in thickness from 150 to 200 mm). Totally realistic premise in future is, that SFRC will be used for load-bearing SFRC structures of aboveground objects. In this case, production of SFRC must take place in concrete plants at higher weight doses than 40 kg/m3 of fibres, to achieve the characteristics of SFRC, which bring effects to SFRC structures. In the paper, there are presented two examples of the production of SFRC in concrete plants. There is specified manufacturing process of production of SFRC in mixers with forced circulation, which is necessary to comply, in order to achieve a homogenous fresh fibre concrete and to minimize wear of machinery.
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Lebovic, Daniel, Tara Kendall, Christine Brozo, Amanda McAllister, Malathi Hari, Sairah Alvi, Ewan J. D. Robson e Andrzej J. Jakubowiak. "Serum Free Light Chain Analysis Improves Monitoring of Multiple Myeloma Patients Receiving First-Line Therapy with the Combination of Velcade, Doxil, and Dexamethasone (VDD)." Blood 110, n.º 11 (16 de novembro de 2007): 2736. http://dx.doi.org/10.1182/blood.v110.11.2736.2736.
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Abstract Introduction: Serum free light chains (sFLC) have a short 2–6hr serum half-life compared with up to 3 weeks for intact immunoglobulins (Ig). sFLC analysis (Freelite™, The Binding Site Inc) therefore provides earlier therapeutic information for Intact Ig Multiple Myeloma (IIMM) patients producing monoclonal FLC. Also, it may be a more sensitive method than urinary Bence Jones protein (BJP) analysis for monitoring light chain MM (LCMM) patients. We assessed the benefits of monitoring sFLC in addition to serum and urine M-protein in previously untreated MM patients receiving combination therapy with Velcade, Doxil, and Dexamethasone (VDD). Methods: 38/40 patients enrolled in a Phase II clinical trial received up to six 3-week VDD cycles (Velcade: 1.3 mg/m2IV; Days 1, 4, 8, 11, Doxil: 30 mg/m2 IV; Day 4, and Dexamethasone: 20 mg PO; Days 1, 2, 4, 5, 8, 9, 11, 12. During the first cycle, Dexamethasone was given at 40 mg per dose, with the first 10 patients receiving Dexamethasone at 40 mg PO on Days 1 – 4). Responses were determined based on uniform response criteria (URC, Durie et al. (2006) Leukemia20, 1467). 31/38 patients had IIMM (16 IgGκ, 8 IgGλ, 5 IgAκ, 2 IgAλ). 7/38 patients had LCMM (3 κFLC, 4 λFLC). 8/31 IIMM and 2/7 LCMM patients had sFLC levels <10mg/dL at baseline, too low to define measurable disease according to the URC. Results: sFLC and intact Ig response was similar in 16/31 IIMM patients (at least partial response (PR), 4/16 had baseline sFLC levels <10mg/dL). In 7/31, the difference between involved and uninvolved sFLC levels fell to <50% of baseline one cycle or more earlier than intact Ig levels indicated at least PR (for 3/7, intact Ig levels indicated stable disease). In 1 patient, intact Ig levels fell to <50% of baseline before sFLC. 2/31 patients displayed probable light chain escape during treatment, with a third patient’s disease progression indicated earlier by sFLC than intact Ig. In 4/31 patients, sFLC analysis provided no useful information. sFLC ratios normalised in 6/31 IIMM patients, supportive of a stringent complete response. 16/31 IIMM patients had no significant BJP; in 15/31 with BJP, changes in sFLC and BJP levels were similar. Changes in sFLC and BJP levels agreed in 5/7 LCMM patients. 2/7 became negative for BJP while continuing abnormal sFLC levels suggested residual disease (in both these patients, baseline sFLC levels were <10mg/dL). Conclusion: Analysing sFLC in addition to intact Ig generated clinically relevant detail in 10/31 (32%) IIMM patients, with earlier response identified in 7 patients and probable disease progression in 3 patients. sFLC analysis provided a more sensitive means of monitoring response to therapy and identifying residual disease in 2/7 (29%) LCMM patients. No clinical information would have been lost by replacing BJP with sFLC analysis when monitoring either IIMM or LCMM. Our data suggests that the URC 10mg/dL baseline sFLC cut-off may not always be appropriate, as sFLC analysis of some patients with <10mg/dL was informative. Furthermore, sFLC analysis can be used in assessing stringent complete response. This analysis of data from a controlled clinical trial shows that sFLC can be used not only as a useful tool to monitor initial therapy of multiple myeloma, but also as a possible replacement for 24-hr BJP analysis.
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Bradwell, Arthur R., Neil D. Evans, Mike J. Chappell, Paul Cockwell, Steven D. Reid, John Harrison, Colin Hutchison e Graham P. Mead. "Rapid Removal of Free Light Chains from Serum by Hemodialysis for Patients with Myeloma Kidney." Blood 106, n.º 11 (16 de novembro de 2005): 3482. http://dx.doi.org/10.1182/blood.v106.11.3482.3482.
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Abstract Introduction. Acute renal failure (ARF) develops in 10–15% of patients with multiple myeloma (MM). Typically, complexes of serum free light chains (sFLC) and Tamm-Horsfall protein form casts in the distal tubules that block urine flow. Many patients, subsequently, require long-term hemodialysis (HD) and may have reduced survival. In an attempt to minimise renal damage, plasma exchange (PE) has been used to reduce the pre-renal load of sFLC. Zucchelli et al., (Kidney Int1988; 33:1175–1180) showed that PE reduced HD requirements but subsequent controlled trials showed no benefit (Johnson WJ et al., Arch Intern Med1990; 150:863–869: Clarke WF et al., Haematologica2005; 90(s1) p117). The availability of sFLC immunoassays now allows an informed evaluation of the role of PE and/or HD in treating these patients. Methods. sFLC were measured in 1: 100 patients with chronic renal failure (CRF), GFR< 15ml/min and not on dialysis; 2: 38 at the beginning and end of HD (dialyzer A) and 3: 25 on chronic ambulatory peritoneal dialysis (CAPD). sFLC hemofiltration efficiency was assessed, in-vitro, for three different dialyzers, using standard pump pressures and flow rates. Sera containing approximately 1,000 mg/L of monoclonal kappa (κ ) (NR < 20mg/L) and lambda (λ ) FLC (NR < 27mg/L) were recycled for ~45 minutes through the dialyzers and clearance rates assessed. A two-compartment, mathematical model was constructed to assess sFLC removal by HD and PE from hypothetical patients. The following parameters were considered:- sFLC concentrations in MM at clinical presentation; monomeric κ or dimeric λ clearance differences; partition of sFLC between vascular and extravascular compartments; flow of FLC between compartments; half-life of sFLC in ARF; sFLC production and tumour killing rates with chemotherapy. The model was interrogated for various dialysis times, different dialyzers and a PE protocol of 3L, x6 over 2 weeks. Results. Mean sFLC concentrations in severe CRF were: κ 93 mg/L (range 43–207); λ 64 mg/L (range 43–134). Mean sFLC before and after HD: κ 130 mg/L (range 40–567) to 49 (range 20–234); λ 100 mg/L (range 31–225) to 61 (range 24–159). Mean sFLC in CAPD patients: κ 118 mg/L (range 31–266); λ 114 mg/L (range 36–263). Clearances of sFLC by the 3 dialyzers were: A: BBraun high flux polyethersulfone 1.8sqm (HI PeS) (the dialyzer in routine use); κ 46%: λ 39%, B: Idmesa high flux polyethersulphone 2.0sqm (200MHP); κ 67%: λ 59%, C: Asahi high flux polysulphone 2.1sqm (APS 1050); κ 71%: λ 65%. Model calculations showed that sFLC reduced from a starting value of 14g/L (typical of light chain MM) to less than 0.5g/L in 14 days using PE. Membrane A, used for four hours, x3/week, was approximately 20% more efficient than PE and reduced κ sFLC approximately 50% faster than the natural clearance rate of patients in ARF. Dialyzers B and C were approximately twice as efficient. Performing initial, 16-hour dialyses daily for 3 days, with dialyzer C reduced sFLC to less than 0.5g/L in 2–3 days with ~95% of the sFLC being removed. Dimeric λ sFLC were removed ~50% more slowly. Conclusion. PE was less efficient at removing sFLC than routine HD. Prolonged HD with high-flux dialyzers removed monoclonal sFLC quickly and should be assessed in a clinical trial for patients with acute myeloma kidney. CAPD was inefficient at removing sFLC.
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You, Peibo, Jie Zhang, Binyu Wang, Yi Wang, Qingjie Yang e Li Li. "Shear Bearing Capacity of Steel-Fiber-Reinforced Concrete Shear Wall under Low-Cycle Repeated Loading Based on the Softened Strut-and-Tie Model". Buildings 14, n.º 1 (20 de dezembro de 2023): 12. http://dx.doi.org/10.3390/buildings14010012.
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In this paper, the loading mechanism of steel-fiber-reinforced concrete (SFRC) shear wall (SW) under low-cycle repeated loading is analyzed, and the softened strut-and-tie model (SSTM) of SFRC SW composed of horizontal and vertical resistant members and diagonal strut is proposed, in which the contributions of distributed web reinforcement, concrete, and steel fiber (SF) to the shear bearing capacity (SBC) of SFRC SW is identified. Furthermore, a new algorithm to obtain the SBC of SFRC SW is established, and then it is validated by using the test results of steel-fiber-reinforced high-strength concrete (SFHSC) SW and SFRC SW under low-cycle repeated loading. The results show that the calculated values are in good agreement with the experimental values for the 11 SFRC SWs, and the average strength ratio between calculated and experimental values (Vjh,t/Vjh,c) is 0.958. Therefore, the proposed calculation method is scientific and accurate for analyzing and predicting the SBC of SFRC SW. In addition, the proposed calculation method can scientifically and accurately analyze and predict the SBC of SFRC SW.
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Jang, Seok Joon, Gwon Young Jeong, Mi Hwa Lee, Keitetsu Rokugo e Hyun Do Yun. "Compressive Strength Effects on Flexural Behavior of Steel Fiber Reinforced Concrete". Key Engineering Materials 709 (setembro de 2016): 101–4. http://dx.doi.org/10.4028/www.scientific.net/kem.709.101.
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This paper presents results of experimental investigation to evaluation the effects of compressive strength on flexural behavior of steel fiber-reinforced concrete (SFRC). For this purpose, normal and high strength SFRCs with two different fiber volume fractions of 0.5 and 1.0% were prepared. Compressive strength, modulus of elasticity, flexural strength and toughness were measured with tests on SFRC cylinders and prisms. Test results indicated that steel fiber volume fraction significantly affects the flexural strength and toughness of SFRC. However, the high strength SFRC showed reduction in flexural toughness compared with the normal strength SFRC. It can be concluded that flexural behavior of SFRC depends on both compressive strength and fiber volume fraction.
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Jiang, Demin, Penghui An, Suping Cui, Shiguo Sun, Jingzong Zhang e Tianfu Tuo. "Effect of Straw Fiber Modification Methods on Compatibility between Straw Fibers and Cement-Based Materials". Advances in Civil Engineering 2020 (31 de janeiro de 2020): 1–16. http://dx.doi.org/10.1155/2020/8392935.
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To improve the utilization of crop straws as a resource and the compatibility between straw fibers and cement-based materials, the hydration of modified straw fiber cement-based composite (SFCC) was studied. The structural characteristic of SFCC was investigated by FTIR, SEM, and XRD. The results show that the setting time of several modified straw fiber SFCC pastes was shorter than that of the unmodified straw fiber SFCC paste, and the best method of fiber modification to improve the setting time of the SFCC paste is Na2O·nSiO2 treatment. The recommended fiber modification method for improving the compatibility between straw fibers and cement-based materials is alkali modification, followed by pure acrylic emulsion modification and Na2O·nSiO2 modification. To improve the strength of SFCC, the straw fiber should be modified by alkali, followed by pure acrylic emulsion and Na2O·nSiO2 modification and the method of water modification is also recommended. The phase types and relative contents of crystalline hydration products mixed with the modified straw fiber SFCC are significantly higher than those of the unmodified fiber SFCC. The fiber treatment method that was most helpful to increase the structural density of hydrates of SFCC was alkali treatment and pure acrylic emulsion treatment, followed by Na2O·nSiO2 treatment.
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Sandfeld-Paulsen, Birgitte, Ninna Aggerholm-Pedersen, Mie Hessellund Samson e Holger Jon Møller. "A Cohort Study of Free Light Chain Ratio in Combination with Serum Protein Electrophoresis as a First-Line Test in General Practice". Cancers 14, n.º 12 (14 de junho de 2022): 2930. http://dx.doi.org/10.3390/cancers14122930.
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Multiple Myeloma (MM) often present with unspecific symptoms, which can lead to diagnostic delay. Serum-free light chain (sFLC) ratio is suggested to replace urine protein electrophoresis (UPE) in the diagnostic work-up of myeloma. We aimed to investigate the performance of the sFLC-ratio in general practice (GP) compared to UPE, just as we explored different sFLC-ratio cut-offs’ influence on diagnostic values. In a cohort of 13,210 patients from GP measures of sFLC-ratio, serum protein electrophoresis (SPE), or UPE were compared to diagnoses of incident M-component related diseases acquired from Danish health registers. UPE and sFLC-ratio equally improved diagnostic values when combined with SPE (sensitivity: SPE and UPE: 95.6 (90.6–98.4); SPE and sFLC-ratio: 95.1 (90.2–98.0)). The addition of the sFLC-ratio to SPE resulted in the identification of 13 patients with MGUS, light chain disease and amyloidosis, which was in line with the addition of UPE to SPE. The number of false-positive tests was UPE and SPE: 364 (11%) and sFLC-ratio and SPE: 677(19%). Expanding sFLC-ratio reference range to 0.26–4.32 resulted in a significant reduction in false positives n = 226 (6%) without loss of patients with clinical plasma cell dyscrasias. sFLC-ratio improves the diagnostic value of SPE in GP. However, due to low specificity and a large number of false positives, expanded cut-off values should be considered.
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Tacchetti, Paola, Serena Rocchi, Annalisa Pezzi, Elena Zamagni, Lucia Pantani, Beatrice Anna Zannetti, Katia Mancuso, Annamaria Brioli, Giovanni Martinelli e Michele Cavo. "Prognostic Impact Of Serum Free Light Chain (sFLC) Assay In Newly Diagnosed Multiple Myeloma (MM) Treated With Bortezomib". Blood 122, n.º 21 (15 de novembro de 2013): 1859. http://dx.doi.org/10.1182/blood.v122.21.1859.1859.
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Abstract Introduction sFLC assay is an important advance in the diagnosis and monitoring of MM, however data on prognostic significance are still limited. Methods We performed a retrospective analysis aimed to investigate the role of sFLC assay as predictor of outcomes in newly diagnosed MM patients (pts) treated up-front with bortezomib based regimens. sFLC assay (Freelite; The Binding Site, Birmingham, UK) was performed by BN II nephelometer (Date Behring, Deerfield, IL, USA). sFLC-k, sFLC-l and sFLC k/l ratio were serially measured at baseline, during treatment and follow-up. sFLC k/l ratios were classified as normal (0.26-1.65) or abnormal (<0.26 or >1.65) according to the IMWG criteria. An involved sFLC level >=100 mg/L, defined by the IMWG criteria as the level to identify a sFLC evaluable disease, was categorized as high. Results We analyzed 110 pts who received first-line bortezomib-based treatments: 67% incorporated into autotransplantation and 33% combined with conventional chemoterapy. The median age was 63 years, 47 pts (43%) were female and 63 (57%) were male. Fifty-eight pts (53%) had IgG heavy chains, 25 (23%) IgA, 1 (1%) IgM and 1 (1%) IgD; 23 pts (21%) had light chain only disease, and 2 pts (2%) had nonsecretory MM. Overall, the involved light chain was kappa in 69 pts (64%), lambda in 36 (33%) and both in 2 (2%), whereas 3 pts (3%) had no detectable light chains. An abnormal sFLC k/l ratio was detected in 91 pts (83%) at baseline, whereas 76 pts (69%) had an involved sFLC >=100 mg/L. The median involved k and l concentrations were 720 and 479 mg/L, respectively. Baseline sFLC >=100 mg/L correlated with higher frequency of Bence Jones isotype (p=0.041), higher beta-2-microglobulin (b2M) (p=0.011), lower hemoglobin concentration (p=0.003) and higher frequency of del(13q) (p=0.016). No correlation was found between high baseline sFLC and other parameters including ISS stage, LDH, bone marrow infiltration, and presence of t(4;14) or del(17p). IMWG response was: 43% stringent complete response (sCR), 11% complete response (CR), 18% very good partial response (VGPR) and 15% partial response (PR). Overall, 83 pts (75%) achieved a normalization of sFLC k/l ratio during treatment. With a median follow-up of 26 months (mos), 36 pts progressed and 17 died. The median time to progression (TTP), progression free survival (PFS) and overall survival (OS) were 46, 46 and 75 mos, respectively. In comparison with a baseline sFLC <100 mg/L, sFLC >=100 mg/L was associated with a reduced rate of sCR/CR (71% vs 48%, p=0.028), a lower probability to normalize sFLC k/l ratio (94% vs 67%, p=0.002) and a shorter median TTP (not reached vs 36 mos, p=0.047) and PFS (not reached vs 35 mos, p=0.034), whereas the OS was similar in the two groups (65 vs 75 mos, p=0.16). By the opposite, pts who achieved a normalization of sFLC k/l ratio during treatment had an extended TTP (53 vs 20 mos, p<0.0001), PFS (53 vs 18 mos, p<0.0001) and OS (not reached vs 75 mos, p=0.0026) in comparison with those who failed this objective. Of the 36 pts who relapsed or progressed, 28 could be assessed for sFLC at relapse. Eleven pts (39%) showed a sFLC escape, defined as an increase of sFLC with no associated increase of intact M protein concentration, that preceded the conventional relapse by a median time of 4 mos. No difference was observed between pts with or without sFLC escape, in terms of time to start second line therapy (1 vs 2 mos, p=0.38) and OS post relapse (p=0.86), whereas sFLC >=100 mg/L at relapse was associated with earlier start of salvage therapy, compared with sFLC <100 mg/L (1 vs 4 mos, p=0.006). A multivariate analysis including age, treatment, b2M, albumin, ISS stage, sFLC and cytogenetic abnormalities identified non-transplant regiments (p<0.001), IIS 3 (p=0.032) and sFLC >=100 mg/L (p=0.047) as variables independently associated with a reduced probability to normalize sFLC k/l ratio. By Cox regression analysis, the normalization of sFLC k/l ratio was an independent factor predicting for extended TTP and PFS (p=0.022 and p=0.001) together with ISS 1-2 (p=0.042 and p=0.007). Conclusions High sFLC at baseline was associated with more aggressive disease characterized by a lower probability to achieve sCR/CR and shorter TTP and PFS. Moreover, high sFLC at relapse predicted for short-lasting asymptomatic phase. By opposite, the achievement of normal sFLC k/l ratio during treatment resulted a considerable prognostic indicator of longer TTP and PFS. Disclosures: Tacchetti: Janssen: Honoraria; Celgene: Honoraria. Zamagni:Janssen-Cilag: Honoraria; Celgene: Honoraria. Brioli:Celgene: Honoraria. Martinelli:Novartis: Consultancy, Speakers Bureau; BMS: Consultancy, Speakers Bureau; Pfizer: Consultancy; Ariad: Consultancy. Cavo:Bristol-Myers Squibb: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Onyx: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Millennium: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Janssen: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Celgene: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees.
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Leleu, Xavier, Evdoxia Hatjiharissi, Aldo M. Roccaro, Anne-Sophie Moreau, Renee Leduc, Marybeth Nelson, Mena Farag, Steven P. Treon e Irene M. Ghobrial. "Serum Immunoglobulin Free Light Chain (sFLC) Is a Sensitive Marker of Response in Waldenstrom Macroglobulinemia (WM)." Blood 110, n.º 11 (16 de novembro de 2007): 1486. http://dx.doi.org/10.1182/blood.v110.11.1486.1486.
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Abstract Background. WM is characterized by excess secretion of IgM in the serum. Response to therapy is assessed according to the Consensus panel recommendations with the use of IgM by serum protein electrophoresis (M spike). However, there are many limitations to the use of M-spike level, and new markers are needed. We, and others, have recently demonstrated that the measurement of involved sFLC values accurately identified patients with poor prognostic features of WM. We sought to determine whether involved sFLC level can be used as a reliable and sensitive marker to study response to therapy in WM. Methods. We prospectively studied M-spike and involved sFLC levels in 32 patients with relapse/refractory WM, treated on two phase II clinical trials, single agent perifosine (N=21; given 150mg oral daily for 28 days), or bortezomib-rituximab (N=13; given IV bortezomib 1.6mg/m2 at days 1, 8, 15 q28 days x 6 cycles and rituximab 375mg/m2 at days 1, 8, 15, 22 on cycles 1 and 4). Levels of sFLC and M spike were measured on day 1 of each cycle. In addition, sFLCs were measured weekly for the first month in the bortezomib-rituximab study (N=12). Responses were assessed after 2 cycles of therapy. Time to response was determined from initiation of therapy to the time of initial response. Results. Characteristics in the overall population were not different between the 2 groups treated, and median values were: beta-2 microglobulin (B2M) 2.7mg/L, hemoglobin level 11g/dL, serum IgM 40g/L, M-spike 2.4g/dL, and involved sFLC 111mg/L. The median follow-up was 5 months, and was not significantly different between the 2 trials. The overall response rate (ORR) of the bortezomib/rituximab clinical trial was 85% and the perifosine clinical trial was 33%. The ORR as calculated by the sFLC in the bortezomib-rituximab trial was 100% and in the perifosine trial was 39%. Eleven (34%) patients achieved better responses by sFLC compared to M spike. Of these, 7 were classified as minor response (MR) by M spike but achieved a partial response by sFLC, and 4 were classified as stable disease by M-spike, but achieved MR using involved sFLC. Only 2 patients (6%) had a better response using M spike compared to sFLC. The overall median time to response was 79 and 110 days using M-spike, and 68 and 41 days using sFLC, in bortezomib-rituximab and perifosine trials, respectively. We next found that neither M-spike nor involved sFLC measured prior to therapy could predict response. We then investigated whether sFLC could predict response to therapy using weekly sFLC for the first month. Among the 14 patients studied, 7 showed a decrease in sFLC within the first month, which predicted response by using M spike. On the other hand, the other 7 patients had an sFLC “flare” within the first 4 weeks of therapy, and these patients had a delayed response to therapy using M spike criteria. Conclusion. Involved sFLC is a sensitive marker for monitoring response to therapy in patients with WM. Using sFLC measurement, we showed a higher response rate in patients treated on 2 prospective clinical trials than using M-spike measurement. More importantly, we demonstrated that responses occurred earlier using sFLC compared to M-spike measurement. sFLC measurement could predict response to therapy within the first month of therapy.
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Mehta, J., E. Vickrey, D. Ramadurai, E. Voigt, C. Fitzpatrick e S. Singhal. "The Relationship Between Serum Free Light Chain Levels and Urine Protein in Patients with IgG or IgA Myeloma." Blood 114, n.º 22 (20 de novembro de 2009): 1810. http://dx.doi.org/10.1182/blood.v114.22.1810.1810.
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Abstract Abstract 1810 Poster Board I-836 The serum free light chain (SFLC) assay is often though to be a replacement for the cumbersome process of 24-hour urine collection for monoclonal protein estimation (http://www.freelite.co.uk/initialinvestigationpro-24.asp; accessed 16 July 2009) despite evidence suggesting that SFLC estimation cannot replace urine protein quantification (Singhal et al. Blood 2007; 109:3611-2). We studied results from patients with IgG or IgA myeloma if all the following criteria were satisfied: concomitant SFLC and 24-hour urine specimens analyzed, no oligoclonal proteins, no diminished free light chain levels (involved or uninvolved). The aim was to study the correlation between SFLC and 24-hour urine total protein (24UTP), 24-hour urine monoclonal protein (24UMP) and urine immunofixation electrophoresis (UIFE). Only concordant abnormal SFLC ratios were considered abnormal (Singhal et al. Blood 2009; 114:38-9). 558 samples in 114 patients were identified. SFLC ratio was abnormal in 242 and normal in 316 (including 2 discordant abnormal). UIFE (available in 540) was negative in 290. The proportion of samples with normal SFLC ratio decreased as 24UTP increased (P<0.001): ≤200 mg - 75% of 243, 200-500 mg 33% of 129, 501-1000 mg - 24% of 54, and >1000 mg - 6% of 32. Similarly, the proportion of samples with normal SFLC ratio declined as 24UMP increased (P=0.001): ≤200 mg (including negative) - 41% of 145, 200-500 mg 4% of 28, 501-1000 mg - 0% of 14, and >1000 mg - 0% of 15. SFLC ratio was normal in 84% of samples with negative UIFE and in 26% of samples with positive UIFE (P<0.0001). Among the 47 samples with abnormal SFLC ratio and negative UIFE, the 24UTP was 47-288 mg (median 112). 24UMP was 35 mg in 1, “faint” in 1, and no restricted bands were seen in ther remaining 45. The table shows the relationship between UPEP, UIFE and SFLC amongst the 540 samples where all 3 tests were available. The presence of any restricted band on UPEP, even if too small to quantify, was considered positive. n=540 Positive UPEP Negative UPEP Positive UIFE Negative UIFE Positive UIFE 222 28 Negative UIFE 17 273 Abnormal SFLC ratio 172 59 184 47 Normal SFLC ratio 67 242 66 243 If a positive UPEP is considered the “gold standard” evidence of the presence monoclonal light chains in the urine, the sensitivity of UIFE in detecting urine monoclonal protein is 93% and that of an abnormal SFLC ratio is 72%. On the other hand, if a positive UIFE is considered the “gold standard” evidence of monoclonal light chains in the urine, the sensitivity of an abnormal SFLC ratio in detecting urine monoclonal protein is 74%. These data, obtained from a much large number of homogeneous clinical samples, confirm our previous observations (Singhal et al. Blood 2007; 109:3611-2) that an abnormal SFLC ratio cannot consistently predict the presence of either non-specific or monoclonal proteinuria. Fortunately, the proportion of urine samples with large aounts of non-specific or monoclonal proteinuria that is associated with normal SFLC ratios is small. The sensitivity of the SFLC ratio in detecting urine monoclonal protein is less than that of UIFE. The SFLC assay cannot replace 24-hour urine collection in clinical practice without compromising patient care. Whether a less cumbersome technique such as a spot (random) urine protein-creatinine ratio - used in conjunction with the SFLC assay - can avert the need for 24-hour urine collections in myeloma patients remains to be investigated. Disclosures No relevant conflicts of interest to declare.
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Zhao, Li Jun, Feng Peng Zhang, Xiao Zhi Hu e Bao Zong Huang. "Study on Interlaminar Shear and Damage Behavior of Carbon Fiber Composites with Short Fiber Interleaves: 1. The Comparative Test". Advanced Materials Research 41-42 (abril de 2008): 335–40. http://dx.doi.org/10.4028/www.scientific.net/amr.41-42.335.
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A special test setup was designed and used in compression shear test of unidirectional carbon fiber composites to study the effect of short fiber interleaves (SFIs) on the interlaminar shear behavior. The comparative tests for two kinds of double-notched compression specimens, with and without SFIs, were carried out to determine the interlaminar shear strength and modulus (ILSS and ILSM) and to examine the failure characteristics. To determine ILSM of the specimens with SFIs an inversion analysis method was proposed based on comparing compression displacement of specimens with and without SFIs. The experimental results show that SFIs makes ILSS decreasing due to lower interface strength, and the complex damage process of SFIs leads to a considerable increase of interlaminar shear compliance.
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Perceka, Wisena, Wen-Cheng Liao e Yung-Fu Wu. "Shear Strength Prediction Equations and Experimental Study of High Strength Steel Fiber-Reinforced Concrete Beams with Different Shear Span-to-Depth Ratios". Applied Sciences 9, n.º 22 (9 de novembro de 2019): 4790. http://dx.doi.org/10.3390/app9224790.
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Conducting research on steel fiber-reinforced concrete (SFRC) beams without stirrups, particularly the SFRC beams with high-strength concrete (HSC) and high-strength steel (HSS) reinforcing bars is essential due to the limitation of test results of high strength SFRC beams with high strength steel reinforcing bars. Eight shear strength prediction equations for analysis and design of the SFRC beam derived by different researchers are summarized. A database was constructed from 236 beams. Accordingly, the previous shear strength equations can be evaluated. Ten high-strength SFRC beams subjected to monotonic loading were prepared to verify the existing shear strength prediction equations. The equations for predicting shear strength of the SFRC beam are proposed on the basis of observations from the test results and evaluation results of the previous shear strength equations. The proposed shear strength equation possesses a reasonable result. For alternative analysis and design of the SFRC beams, ACI 318-19 shear strength equation is modified to consider steel fiber parameters.
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You, Peibo, Shuaiqi Song, Haiyang Zhang, Lijuan Zhang, Ke Shi e Yi Wang. "Shear Strength Prediction for SFRC Shear Wall with CFST Columns by Softened Strut and Tie Model". Advances in Civil Engineering 2020 (29 de julho de 2020): 1–16. http://dx.doi.org/10.1155/2020/8824308.
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The steel fiber reinforced concrete (SFRC) shear wall with concrete filled steel tube (CFST) columns is an innovative composite structure. In order to calculate the shear strength of SFRC shear wall with CFST columns, the softened strut and tie model (SSTM) of SFRC shear wall with CFST columns was proposed based on the analysis of shear mechanism of SFRC shear wall with CFST columns. The SSTM was composed of diagonal, horizontal, and vertical mechanisms, in which the contributions of concrete, reinforcement, and steel fiber to the shear strength of SFRC web of shear wall were identified. The shear capacities of 24 shear walls were calculated and compared with the available test results, and reasonable agreement was obtained. The results also showed that the steel fibers distributed randomly in concrete could be treated as longitudinal and transverse reinforcement in the shear strength analysis of SFRC web, and the SSTM was reasonable and useful to analyze and predict the shear strength of SFRC shear wall with CFST columns.
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Zhang, Peng, Luoyi Kang, Juan Wang, Jinjun Guo, Shaowei Hu e Yifeng Ling. "Mechanical Properties and Explosive Spalling Behavior of Steel-Fiber-Reinforced Concrete Exposed to High Temperature—A Review". Applied Sciences 10, n.º 7 (28 de março de 2020): 2324. http://dx.doi.org/10.3390/app10072324.
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Steel-fiber-reinforced concrete (SFRC) is being increasingly applied to various buildings and civil infrastructure as an advanced cementitious composite. In recent years, the requirements for SFRC in the construction industry have increased. Additionally, the fire resistance of SFRC has attracted attention; therefore, numerous investigations regarding the residual properties of SFRC have been conducted. This paper critically reviews the mechanical properties of SFRC subjected to elevated temperatures, including its residual compressive strength, flexural strength, tensile strength, elastic properties, fracture properties, and stress–strain relationships. The residual mechanical performance of SFRC and the action mechanism of steel fibers are reviewed in detail. Moreover, factors affecting the explosive spalling of concrete at high temperatures as well as the effect of steel fibers on the microstructure of heated concrete are discussed. It is demonstrated that, in general, SFRC exhibits better residual mechanical properties when exposed to elevated temperatures than plain concrete and can prevent the risk of explosive spalling more effectively. The purpose of this literature review is to provide an exhaustive insight into the feasibility of SFRC as a refractory building material; additionally, future research needs are identified.
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Ding, Xinxin, Minglei Zhao, Siyi Zhou, Yan Fu e Changyong Li. "Statistical Analysis and Preliminary Study on the Mix Proportion Design of Self-Compacting Steel Fiber Reinforced Concrete". Materials 12, n.º 4 (20 de fevereiro de 2019): 637. http://dx.doi.org/10.3390/ma12040637.
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With the sustainable development of green construction materials in civil engineering, self-compacting steel fiber reinforced concrete (SC-SFRC) has attracted widespread attention due to its superior self-compacting performance and excellent hardened properties. In this paper, 301 groups of test data from published literatures were collected to quantify the characteristics of the mix proportion of SC-SFRC. The type, aspect ratio and volume fraction of steel fiber commonly used in SC-SFRC are discussed and the effects of steel fiber on the workability and mechanical properties of SC-SFRC are statistically studied. The relationship of cubic compressive strength and water-to-binder ratio and that of the splitting tensile strengths between SC-SFRC and referenced self-compacting concrete (SCC) are also evaluated. Based on these analyses, the reasonable ranges of material components in the mix proportion design of SC-SFRC are determined. The results showed that with several adjusted parameters, the calculation model of the water-to-binder ratio for the mix proportion design of ordinary concrete is suitable for SC-SFRC. The calculation model of tensile strength is suggested for SC-SFRC with various types of steel fiber.
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Correa-Garcia, Sara, Vincenzo Corelli, Julien Tremblay, Jessica Ann Dozois, Eugenie Mukula, Armand Séguin e Etienne Yergeau. "Soil fauna-microbial interactions shifts fungal and bacterial communities under a contamination disturbance". PLOS ONE 18, n.º 10 (25 de outubro de 2023): e0292227. http://dx.doi.org/10.1371/journal.pone.0292227.
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The aim of this study was to determine whether the soil faunal-microbial interaction complexity (SFMIC) is a significant factor influencing the soil microbial communities and the willow growth in the context of PAH contamination. The SFMIC treatment had eight levels: just the microbial community, or the microbial community with nematodes, springtails, earthworms and all the possible combinations. SFMIC affected the height and biomass of willows after eight weeks or growth. SFMIC affected the structure and the composition of the bacterial, archaeal and fungal communities, with significant effects of SFMIC on the relative abundance of fungal genera such as Sphaerosporella, a known willow symbiont during phytoremediation, and bacterial phyla such as Actinobacteriota, containing many polycyclic aromatic hydrocarbons (PAH) degraders. These SFMIC effects on microbial communities were not clearly reflected in the community structure and abundance of PAH degraders, even though some degraders related to Actinobacteriota and the diversity of Gram-negative degraders were affected by the SFMIC treatments. Over 95% of PAH was degraded in all pots at the end of the experiment. Overall, our results suggest that, under our experimental conditions, SFMIC changes willow phytoremediation outcomes.
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Morabito, Fortunato, Rosaria De Filippi, Luca Laurenti, Katja Zirlik, Anna Grazia Recchia, Massimo Gentile, Emanuela Morelli et al. "The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia". Blood 118, n.º 24 (8 de dezembro de 2011): 6353–61. http://dx.doi.org/10.1182/blood-2011-04-345587.
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AbstractIdentification of patients at risk of early disease progression is the mainstay of tailored management in chronic lymphocytic leukemia (CLL). Although application of established biomarkers is limited by intrinsic detection/readout complexities, abnormality of κ and λ serum-free light chain ratio [sFLC (κ/λ)] was proposed as a straightforward prognosticator in CLL. By analyzing 449 therapy-naive patients, we show that an abnormal sFLC(κ/λ), along with CD38, ZAP-70, IGHV mutations, cytogenetics and stage, independently predicts treatment-free survival (TFS) but becomes prognostically irrelevant if the cumulative amount of clonal and nonclonal FLCs [sFLC(κ + λ)], a variable associated with cytogenetic risk, exceeds the threshold of 60.6 mg/mL. Patients with sFLC(κ + λ) above cut-off displayed a poorer TFS outcome, irrespective of sFLC(κ/λ). Only ZAP-70, cytogenetics, stage, and TFS remained associated with sFLC(κ + λ) in a multivariate model. By assigning 1 point each for these variables, the 3-year probability of TFS was 94.8%, 84.5%, 61.6%, and 21.1% for patients scoring 0, 1, 2, and 3 + 4, respectively (P < .0001). These data, and the demonstration that monoclonal and polyclonal B cells concur to FLC synthesis in tumor tissues, suggest that sFLC(κ/λ) and sFLC(κ + λ) mirror distinct biologic processes in CLL. sFLC(κ + λ) assessment represents a sensitive and cost-effective tool for identifying CLL patients requiring early treatment.
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Zhao, Yuling, Hao Shi, Xin Tang, Daihong Kuang, Jinlong Zhou e Fangyuan Yang. "Performance and Mechanism of As(III/V) Removal from Aqueous Solution by Fe3O4-Sunflower Straw Biochar". Toxics 10, n.º 9 (11 de setembro de 2022): 534. http://dx.doi.org/10.3390/toxics10090534.
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Humans and ecosystems are severely damaged by the existence of As(III/V) in the aquatic environment. Herein, an advanced Fe3O4@SFBC (Fe3O4-sunflower straw biochar) adsorbent was fabricated by co-precipitation method with sunflower straw biochar (SFBC) prepared at different calcination temperatures and different SFBC/Fe mass ratios as templates. The optimal pH for As(III/V) removal was investigated, and Fe3O4@SFBC shows removal efficiency of 86.43% and 95.94% for As(III) and As(V), respectively, at pH 6 and 4. The adsorption effect of calcining and casting the biochar-bound Fe3O4 obtained at different temperatures and different SFBC/Fe mass ratios were analyzed by batch experiments. The results show that when the SFBC biochar is calcined at 450 °C with an SFBC/Fe mass ratio of 1:5, the adsorption of As(III) and As(V) reaches the maximum, which are 121.347 and 188.753 mg/g, respectively. Fe3O4@SFBC morphology, structure, surface functional groups, magnetic moment, and internal morphology were observed by XRD, FTIR, SEM, TEM, and VSM under optimal working conditions. The material shows a small particle size in the range of 12–14 nm with better magnetic properties (54.52 emu/g), which is suitable for arsenic removal. The adsorption mechanism of As(III/V) by Fe3O4@SFBC indicates the presence of chemisorption, electrostatic, and complexation. Finally, the material was used for five consecutive cycles of adsorption–desorption experiments, and no significant decrease in removal efficiency was observed. Therefore, the new adsorbent Fe3O4@SFBC can be efficiently used for arsenic removal in the aqueous system.
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Setyawan, Eko, Mohd Agus Nashri Abdullah e M. Aman Yaman. "Efek Substitusi Kombinasi Tepung Maggot (Hermetia Illucens) Dan Sprouted Fodder For Chicken (Sf2c) Dalam Pakan Fermentasi Terhadap Kualitas Makroskopis Dan Mikroskopis Sperma Ayam Jantan Fi Hasil Persilangan Ayam Lokal Dan Ayam Brahma". Jurnal Ilmiah Mahasiswa Pertanian 7, n.º 2 (1 de maio de 2022): 279–92. http://dx.doi.org/10.17969/jimfp.v7i2.19943.
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Abstrak . Penelitian ini bertujuan untuk mengetahui kualitas sperma ayam dengan penambahan tepung maggot (Hermetia illucens) dan pakan kecambah untuk ayam (SF2C) pada taraf taraf yang berbeda. Materi penelitian merupakan 16 ekor pejantan ayam ALOBRA Penampungan sperma dilakukan dengan cara pengurutran . Semen yang diperoleh secara makroskopis meliputi volume, warna, konsitensi, bau, dan pH. Sementara evaluasi mikroskopis meliputi konsentrasi, gerakan massa, gerakan individu, viabilitas, dan abnormalitas.Pejantan ayam ALOBRA diberikan ransum dengan perlakuan, selanjutnya disubstitusi dengan tepung maggot dan SF2C dengan masing-masing 0%, 3%, 6%, dan 9% sesuai dengan tingkat pemberian tepung masing-masing dan SF2C. Hasil penelitian menunjukkan bahwa penggunaan tepung maggot dan SF2C dalam pakan sangat berpengaruh nyata (P0,01) terhadap konsentrasi, motilitas individu, dan abnormalitas. Penggunaan tepung maggot dan SF2C 9% pasti penggunaannya untuk meningkatkan konsentrasi dan menekan abnormalitas pada semen.Pengaruh Substitusi Pakan Fermentasi Mengandung Tepung Maggot (Hermetia Illucens) dan Pakan Kecambah Untuk Ayam (SF2C) Terhadap Kualitas Makroskopik dan Mikroskopis Sperma FI Persilangan Ayam Lokal dan Ayam BrahmaAbstrak. This study aims to determine the quality of chicken sperm with the addition of maggot flour (Hermetia illucens) and sprouted fodder for chicken (SF2C) at different levels. The research material was 16 male ALOBRA chickens. Sperm collection was carried out by massage. The obtained semen was evaluated macroscopically including volume, color, consistency, odor, and pH. While microscopic evaluation includes concentration, mass movement, individual movement, viability, and abnormalities. The male ALOBRA chickens were fed with treatment, then substituted with maggot flour and SF2C with 0%, 3%, 6%, and 9% respectively according to the level of treatment with maggot flour and SF2C. Hasil penelitian menunjukkan bahwa penggunaan tepung maggot dan SF2C dalam pakan berpengaruh nyata (P0,01) terhadap konsentrasi, motilitas individu, dan kelainan. Penggunaan tepung maggot dan SF2C 9% lebih disarankan untuk meningkatkan konsentrasi dan menekan gangguan pada semen.
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Itzykson, Raphael, Magali Le Garff-Tavernier, Sandrine Katsahian, Marie-Claude Diemert, Laurence Guis, Sylvain Choquet, Lucile Musset e Veronique Leblond. "Serum Free Light Chain (SFLC) Elevation Is Associated with High β2-Microglobulin and with a Shorter Time to Treatment in Waldenström Macroglobulinemia (WM)." Blood 108, n.º 11 (1 de novembro de 2006): 2419. http://dx.doi.org/10.1182/blood.v108.11.2419.2419.
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Abstract WM is a rare lymphoproliferative disorder caracterised by bone marrow lymphoplasmacytic infiltration with IgM monoclonal gammopathy. Assessing the tumor burden in WM is challenging and is not directly related to IgM level or bone marrow infiltration. Thus treatment criteria are based on clinical symptoms related to IgM or pancytopenia. SFLC quantification is a useful tool for the diagnosis and follow-up of gammopathies such as amyloidosis and light chain myeloma. So far its quantification has never been studied in WM. We investigated whether SFLC quantification was correlated with monoclonal component value and established prognostic factors, or was predictive of a shorter time to treatment. We analyzed 45 untreated WM patients (IgMκ: 37; IgMλ: 8) at the time of diagnosis (n=23) or during the follow-up (n=22). Patients were assessed for physical examination, body CT scan, serum protein electrophoresis with albumin (g/l) and monoclonal component (g/L) measurements, SFLC level (The Binding Site®, cut-off: SFLCκ 19.4 mg/L and SFLCλ 26.3 mg/L), peripheral blood count and β2-microglobulin (β2-m). Cut-off values of prognostic factors were those defined by the International Prognostic Index for WM (Morel ASH 2006) ie. β2-m > 3mg/L, Hb < 115 g/L, platelets < 100 G/L, albumin < 35 g/L. Treatment was initiated at diagnosis in 7 patients or during the follow-up in 23 patients. Median follow-up for the whole population was 15 months (1 – 74). Median SFLCκ value was 39 mg/L (1.73–399), median SFLCλ was 12.6 mg/L (1.93–19400). 75 % of patients had upper to normal SFLC value (34/45). Table 1 summarizes univariate analysis of (1) the relationship between high SFLC value (SFLC > N) and known biological prognostic factors, and (2) the impact of SFLC > N and other biological parameters on time to treatment. Our results showed that high SFLC correlated with β2-m but not with other biological prognostic factors or with monoclonal IgM value. (2) Patients with SFLC > N had a shorter time to treatment than patients with normal SFLC value. Furthermore, taking SFLC as a continuous variable in patients with SFLC > N, treatment time was strongly correlated to the SFLC quantification (κ: p=0.01; λ: p=0.01). SFLC could thus be used as a new marker of tumor burden in WM and its prognostic value must be tested in larger WM series. The correlation between SFLC variation and response to treatment is still under investigation. Table 1 SFLC > N (1) time to treatment (2) SFLC > N NA p=0.03 monoclonal IgM value p=0.08 p=0.001 β2-m > 3 mg/L p=0.03 p=0.44 Hb < 115 g/L p=0.43 p=0.009 Platelets < 100 G/L p=1 p=0.36 Albumin < 35 g/L p=0.3 p=0.011
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Zhu, Hai Tang, Xiang Qian Fan, Qiming Zhang e Jinzhang Li. "Experimental Study on the Damage of Steel Fiber Reinforced Concrete by Simulation Domestic Sewage". Advanced Materials Research 168-170 (dezembro de 2010): 1801–5. http://dx.doi.org/10.4028/www.scientific.net/amr.168-170.1801.
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Through the corrosion-damaged experiment of steel fiber reinforced concrete (SFRC) in simulation domestic sewage, the corrosion resistance of SFRC placed in domestic sewage were investigated. The results show that high concentration domestic sewage would cause the properties of SFRC to deteriorate, and the corrosion coefficients of compressive and flexural strength of SFRC decrease gradually with the increase of corroding age. The steel fiber can not inhibit obviously the degradation of concrete compressive and flexural strength unless the steel fiber volume fraction is more than 1.0%. The size effect on compressive and flexural strength of SFRC after corroding in domestic sewage is existent.
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Henriot, Basile, Emmanuel Rouger, Chloé Rousseau, Martine Escoffre, Martine Sébillot, Claude Bendavid, Stéphane Minvielle, Hervé Avet-Loiseau, Olivier Decaux e Caroline Moreau. "Prognostic value of involved/uninvolved free light chain ratio determined by Freelite and N Latex FLC assays for identification of high-risk smoldering myeloma patients". Clinical Chemistry and Laboratory Medicine (CCLM) 57, n.º 9 (27 de agosto de 2019): 1397–405. http://dx.doi.org/10.1515/cclm-2018-1369.
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Abstract Background Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder with a high risk of progression to symptomatic multiple myeloma (MM). The serum free light chain (sFLC) ratio is a powerful prognostic factor for SMM: an sFLC ratio ≥8 has been reported to be associated with a high risk of progression to MM, and an sFLC ratio ≥100 has been described as a criterion for ultra-high-risk SMM, and has been integrated into the definition criteria for MM since 2014. However, all recommendations were based on sFLC measured using the first commercialized assay, Freelite™, while other assays are now available. We aimed to evaluate the safety and accuracy of N-Latex sFLC to identify high-risk and ultra-high-risk SMM. Methods The sFLC ratio was measured at diagnosis with both Freelite and N-Latex assays in a cohort of 176 SMM patients on a BN Prospec nephelometer. Demographic, clinical, therapeutic and laboratory data were collected at the time of diagnosis and at follow-up. Results Sixty-two patients (35.2%) progressed to MM within 2 years. Compared to Freelite™ sFLC, N Latex sFLC ratios ≥8 and ≥100 provided similar performances for the identification of high-risk and ultra-high risk SMM patients. Conclusions Our results evidenced that the N-Latex assay could be used for SMM monitoring, like Freelite. However, an N-Latex sFLC ratio ≥70 appears to provide similar performances to a Freelite sFLC ratio ≥100, with a slightly better positive predictive value. Both assays provided accurate identification of high-risk and ultra-high risk SMM patients. These results should be confirmed in an independent study.