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Teses / dissertações sobre o tema "Screening mechanisms"

Autor: Grafiati

Publicado: 23 de novembro de 2024

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1

Ruiz, Carmona Sergio. "Virtual screening for novel mechanisms of action: applications and methodological developments." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/400297.

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The main motivation of this thesis has been to validate, improve and develop new methods with respect to the ones available nowadays in the area of drug discovery, in order to be able to study more challenging targets in the near future that currently are out of our reach. As the productivity of the pharmaceutical industry is decreasing year after year over the last decades, the improvement of such methods would be a step forward. As we are mostly a computational lab, this thesis has focused on different computational approaches such as docking, molecular dynamics or chemoinformatics. O

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Jaworek, Karolina. "Screening for novel brain tumour initiation mechanisms at single cell resolution." Thesis, Bangor University, 2016. https://research.bangor.ac.uk/portal/en/theses/screening-for-novel-brain-tumour-initiation-mechanisms-at-single-cell-resolution(3bb44859-bc78-4fce-a7df-0f47d2dd6b4e).html.

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Despite progress in our understanding of origin and development of brain tumours, more efficient therapeutic approaches addressing the high recurrence rate and poor prognosis of brain tumours remain urgently needed, in particular for the most aggressive glioblastomas (GBMs). In this work, I used the Drosophila brain tumour (brat) mutant as an in vivo model to identify potential mechanisms of brain tumour initiation. The human brat orthologue, Trim3, has a conserved tumour suppressor function in GBMs. I applied a single cell transcriptome microarray technique to compare intermediate neural prog

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3

Wang, An Qi. "Screening of hepatoprotective constituents from herbal medicines and investigation on the underlying mechanisms." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3690819.

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Ibaraki, Alicia. "Mechanisms that perpetuate health disparities: physician stereotypes & bias." Thesis, University of Oregon, 2018. http://hdl.handle.net/1794/23088.

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Purpose: Although Asian Americans are the only racial group for whom cancer is the leading cause of death, colorectal cancer screening is consistently lower than that of White Americans. Physicians also recommend colorectal cancer screening to Asian Americans at nearly half the rate as White Americans. This study tests a mechanism that may underlie low recommendation rates. I based my hypothesis on a conceptual model that integrates the literature on information processing and decision making with Asian American stereotypes. Methods: I conducted an online study of primary care physici

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Thistlethwaite, Rebecca Janette. "Identification of genetic variation in heat stress, genotype screening for and mechanisms of tolerance in wheat." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17339.

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Increasing global climatic variability will most likely increase temperatures and reduce annual rainfall in many cropping regions in the coming years. Changes in seasonal conditions are likely to have a significant impact on all food crops including wheat. This thesis aims to (1) identify genetic diversity for high temperature tolerance in bread wheat by evaluating a large number of genotypes across years and sowing dates, (2) evaluate a subset of germplasm was using different screening methods for heat tolerance (in-field controlled environment chambers and glasshouses) and (3) compare diffe

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Niegowski, Damian. "Structural biology of integral membrane proteins from methods to molecular mechanisms /." Doctoral thesis, Stockholm : Department of Biochemistry and Biophysics, Stockholm Univeristy, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-30069.

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7

Tsipa, Anastasia Isavella. "Understanding the factors and mechanisms that influence colorectal cancer screening uptake among socially deprived and non-deprived populations." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22226/.

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Colorectal cancer (CRC) is the second most common cause of cancer death in the UK. Since the introduction of the NHS Bowel Cancer Screening Programme CRC incidence and mortality rates have reduced, however, screening uptake in the overall population remains suboptimal and is disproportionately low among populations with low socioeconomic status (SES) and Black and Minority Ethnic populations. This thesis aimed to critically assess the available evidence of public health interventions to improve CRC screening and to examine the possible mechanisms of socioeconomic inequalities in CRC screening

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8

Piotrowska, Barbara. "Investigating the performance and underlying mechanisms of a novel screening measure for developmental dyslexia : implications for early identification." Thesis, Edinburgh Napier University, 2018. http://researchrepository.napier.ac.uk/Output/1253563.

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Developmental dyslexia is a common disorder affecting around 10% of the British population characterized by difficulties with reading despite adequate intelligence and education (IDA, 2007). Although most researchers and practitioners would agree that early identification is key in limiting negative consequences of reading problems, this is still difficult to achieve due to theoretical and practical inconsistencies in the field. This thesis focuses on investigating a novel, computer and tablet-based “dot-to-dot” (DtD) task that may aid the process of identification particularly in pre-reading

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9

Theodorou, Andria Soteri. "Screening and delineation of molecular mechanisms of action of HbF inducing agents for the treatment of β-thalassaemia". Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/screening-and-delineation-of-molecular-mechanisms-of-action-of-hbf-inducing-agents-for-the-treatment-of-thalassaemia(fbad43de-f2b2-49a1-980b-b6dfcc1a25c5).html.

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Current agents used for pharmacological reactivation of foetal haemoglobin (HbF) have limited application due to moderate therapeutic properties, variable patient response and potential cytotoxic effects. Therefore, identification of novel HbF inducing agents is still a major research goal to this day. Identification of new potential HbF inducers has been mainly based on screening of drug libraries. However, this approach has not been very successful in generating new promising agents. In the current project, I employed two approaches for identifying potential HbF inducers: 1) screening of age

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10

White, Rose. "Cyclin dependent kinase like 5 (CDKL5) mutation screening in Rett Syndrome and related clinical disorders." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28108.

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Rett Syndrome (RTT) is a severe neurodevelopmental disorder affecting almost exclusively females, with an incidence of 1 in 8,000 by 15 yrs of age. The disorder encompasses a wide spectrum of clinical phenotypes. Up to 95% of classical RTT and a lesser proportion (20%-60%) of those with atypical forms of RTT patients carry mutations in the X-linked MECP2 gene (Methyl-CpG binding protein 2), the first gene discovered to be associated with this disorder. Mutations in the X-Iinked CDKL5 gene (cyclin-dependent kinase-like 5) have also been found to cause atypical RTT (in particular, the ea

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11

Meier, Dieter [Verfasser], Rainer [Akademischer Betreuer] Kalscheuer, and Peter [Gutachter] Proksch. "Screening for novel antimicrobial agents and elucidation of the corresponding mechanisms / Dieter Meier ; Gutachter: Peter Proksch ; Betreuer: Rainer Kalscheuer." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1216330239/34.

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12

Lévy, Hugo. "Towards well-posed and versatile numerical solutions of scalar-tensor theories of gravity with screening mechanisms : applications at sub-Solar system scales." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASP119.

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Les théories tenseur-scalaires de la gravité font partie des alternatives à la Relativité Générale les plus convaincantes, résilientes, et riches en termes de phénoménologie. Les modèles encore viables aujourd'hui reposent sur des mécanismes d'écrantage afin d'être compatibles avec les tests locaux de la gravité, tout en conservant une certaine pertinence physique. La recherche de ces champs scalaires hypothétiques dépend alors de notre capacité à concevoir des expériences adaptées à leur phénoménologie. Hélas, cette tâche est grandement entravée par la difficulté de modéliser suffisamment pré

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13

Veeranki, Sreenivas P., and Shimin Zheng. "Trends and Determinants of Up-to-date Status with Colorectal Cancer Screening in Tennessee, 2002-2008." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/49.

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BACKGROUND: Screening rates for colorectal cancer (CRC) are increasing nationwide including Tennessee (TN); however, their up-to-date status is unknown. The objective of this study is to determine the trends and characteristics of TN adults who are up-to-date status with CRC screening during 2002-2008. METHODS: We examined data from the TN Behavioral Risk Factor Surveillance System for 2002, 2004, 2006 and 2008 to estimate the proportion of respondents aged 50 years and above who were up-to-date status with CRC screening, defined as an annual home fecal occult blood test and/or sigmoidoscopy o

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14

L'hôte, Valentin. "Senolytic drug discovery and mechanisms of action in BRAF-V600E oncogene-induced senescence." Thesis, université Paris-Saclay, 2022. http://www.theses.fr/2022UPASL042.

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En réponse à l'expression d'oncogène (tel que BRAF-V600E), à des traitements génotoxiques ou à d'autres stress, les cellules eucaryotes peuvent éviter l'apoptose et déclencher la sénescence. La sénescence est un destin cellulaire caractérisé par un arrêt prolifératif quasi-irréversible et une reprogrammation transcriptionnelle profonde, conduisant notamment à une sécrétion importante de facteurs inflammatoires collectivement appelés phénotype sécrétoire associé à la sénescence (SASP). En raison de l'augmentation de la demande sécrétoire et de stress chroniques, la protéostase peut être perturb

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15

AMADORI, LETIZIA. "IDENTIFICATION OF MOLECULAR MECHANISMS RESPONSIBLE FOR DEGRADATION OF THE TUMOR SUPPRESSOR PROTEIN NUMB IN CANCER." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/234136.

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ABSTRACT NUMB was initially described as a cell fate determinant involved in neurogenesis. More recently, NUMB has been implicated in different types of human cancers, in which it has a tumor suppressor role. In particular, data from our laboratory revealed that loss of NUMB protein occurred in approximately 50% of breast cancers and 30% of non-small cell lung cancers, and leads to increased oncogenic NOTCH activity and decreased p53 tumor suppressor function. Mechanistically, loss of NUMB in human breast cancers is due to its deregulated ubiquitination and ensuing proteasomal degradation

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16

Jayol, Aurélie. "Résistance à la colistine chez les bacilles Gram négatif." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0179/document.

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Les entérobactéries productrices de carbapénèmases peuvent être responsables d’impasses thérapeutiques puisque ces souches sont multirésistantes aux antibiotiques. La colistine, un antibiotique de la famille des polymyxines, fait partie des molécules de derniers recours potentiellement utilisables pour le traitement des patients infectés par ces souches. Son utilisation est ainsi en augmentation constante mais des résistances émergent.Ce travail a contribué à l’amélioration du diagnostic de la résistance à la colistine par le développement de deux nouveaux outils diagnostiques : un test rapide

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17

Kramm, Anneke. "Identification and characterisation of epigenetic mechanisms in osteoblast differentiation of human mesenchymal stem cells." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:b6f7a356-b20f-4988-8770-8bebc233bf4b.

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A major therapeutic challenge in musculoskeletal regenerative medicine is how to effectively replenish bone tissue lost due to pathological conditions such as fracture, osteoporosis, or rheumatoid arthritis. Mesenchymal stem cells are currently investigated for applications in bone-tissue engineering and human bone marrow-derived mesenchymal stem cells (hMSCs) could be a promising source for generation of tissue-engineered bone. However, the therapeutic potential of MSCs has not been fully exploited due to a lack of knowledge regarding the identity, nature, and differentiation of hMSCs. Epigen

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18

Sleigh, James Nicholas. "Model systems for exploring new therapeutic interventions and disease mechanisms in spinal muscular atrophies (SMAs)." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:378416c5-a586-4a2a-980c-81dfff6803df.

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Spinal muscular atrophy (SMA) and Charcot-Marie-Tooth disease type 2D (CMT2D)/distal SMA type V (dSMAV) are two incurable neuromuscular disorders that predominantly manifest during childhood and adolescence. Both conditions are caused by mutations in widely and constitutively expressed genes that encode proteins with essential housekeeping functions, yet display specific lower motor neuron pathology. SMA results from recessive inactivating mutations in the survival motor neuron 1 (SMN1) gene, while CMT2D/dSMAV manifests due to dominant point mutations in the glycyl-tRNA synthetase (GlyRS) gene

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19

Lundkvist, Jonas. "The role of economic evaluations in health care decision making /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-423-6/.

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20

Sardari, Lodriche Soroush. "Natural antifungals, screening, isolation, synthesis, and mechanism of action." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0006/NQ29103.pdf.

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21

Ishii, Takafumi. "Novel antitumor microbial metabolites obtained through the mechanism-oriented screening." Kyoto University, 2000. http://hdl.handle.net/2433/151634.

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22

Soroush, Fariborz. "A Novel Microfluidic System for Screening Anti-inflammatory Therapeutics." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/500666.

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Mechanical Engineering<br>Ph.D.<br>Inflammation is a crucial physiological protective response of body to infection or injury. However, in pathological conditions such as sepsis or radiation damage, the body may exhibit a strong inflammatory response and cause organ damage. Loss of barrier function and leukocyte dysfunction plays an important role during inflammation (e.g. sepsis, radiation exposure, etc.) and induces tissue injury through release of proteases and oxygen radicals. Currently, pharmacological therapies for inflammatory conditions are supportive and there is an urgent need for sp

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23

Hearn, Jessica M. "Integrating cell screening and mechanism of action data for organometallic anticancer agents." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/68071/.

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Both acquired and intrinsic drug resistance are established clinical problems in many areas of medicine. This is particularly evident with the growing resistance to platinum chemotherapy agents in cancer treatment programmes. New, alternative treatments for platinum-resistance patients are needed, with comparable potency, no platinum cross- resistance, better safety profiles and which target non-repairable areas of the cell, reducing acquired resistance. This thesis focuses on osmium- and iridium-based organometallic anticancer agents to fill this clinical need. Previous work has validated the

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24

Rickardson, Linda. "New Methods to Screen for Cancer Drugs and to Evaluate their Mechanism of Action." Doctoral thesis, Uppsala University, Clinical Pharmacology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8440.

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<p>Cancer is a common disease and due to problems with resistance against cancer drugs and the limited benefit from chemotherapy in many diagnoses, there is a need to develop new cancer drugs. In this thesis new methods to screen for cancer drugs and to evaluate their mechanism of action are discussed. </p><p>In Paper I, it was found that by studying the gene expression of a cell line panel and combining the data with sensitivity data of a number of cytotoxic drugs, it was possible to cluster compounds according to mechanism of action as well as identifying genes associated with chemosensitivi

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25

Khihon, Rokhas Maria. "Development of an assay for screening drug candidates for mechanism-based inhibition of human CYP3A4." Thesis, Södertörn University College, School of Life Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-1770.

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<p>Cytochrome P450 (CYP) constitutes a superfamily of heme- containing enzymes that catalyze the oxidative biotransformation of structurally diverse xenobiotics including pharmaceuticals and drugs. Cytochrome P450 3A4 is not only the most abundant isoform in human liver but is also responsible for metabolizing approximately 60% of therapeutic drugs. This feature makes CYP3A4 highly susceptible to both reversible and irreversible, such as mechanism-based, inhibition. Mechanism-based inhibition is characterized by being time dependent as well as NADPH and concentration dependent, when some drugs

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Méar, Loren. "Recherche de biomarqueurs de l’endométriose par des approches de protéomique et de génomique intégrative Endometriosis screening in patients attending an IVF clinic: a proof-of-concept retrospective cohort study. Polymorphisms and endometriosis: a systematic review and meta-analyses The eutopic endometrium proteome in endometriosis reveals candidate markers and molecular mechanisms of physiopathology Biomarqueurs de l’endométriose : où en sommes-nous ?" Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLV099.

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L'endométriose est une pathologie gynécologique oestrogèno-dépendante et inflammatoire caractérisée par le développement d’endomètre fonctionnel hors de la cavité utérine. Cette maladie est fréquente puisqu’il est estimé que 10% des femmes en activité génitale en seraient atteintes.Bien qu’il existe des formes asymptomatiques de l’endométriose, cette pathologie peut également entrainer des symptômes douloureux ainsi qu’une infertilité ; impactant fortement la qualité de vie des femmes atteintes d’endométriose.À ce jour, l’absence de test de dépistage non invasif fiable explique en partie que p

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Hunte, Cyril Kenrick. "Loan default and the efficacy of the screening mechanism : the case of the development bank in Guyana /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487843688957261.

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Zhu, Seng. "Study of the mechanism of Tunneling nanotubes formation and their role in aggregate proteins transfer between cells." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS377.

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Les Tunneling nanotubes (TNT) sont des protrusions cellulaires à base d'actine qui médient la communication cellulaire en transférant des cargos cellulaires. Les différents types de communication intercellulaires sont de plus en plus considérés comme des cibles potentielles pour le traitement de différentes maladies, telles que les maladies infectieuses liées aux virus et bactéries, les cancers ou les maladies neurodégénératives. Des études récentes ont mis en évidence un mécanisme de propagation d'agrégats protéiques ressemblant à la propagation du prion dans diverses maladies neurodégénérati

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Kitahara, Nao. "Study on screening of novel pathogenic factors of Candida albicans by proteome analysis and its putative virulent mechanism." Kyoto University, 2016. http://hdl.handle.net/2433/215600.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19774号<br>農博第2170号<br>新制||農||1040(附属図書館)<br>学位論文||H28||N4990(農学部図書室)<br>32810<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田充美, 教授栗原達夫, 教授矢﨑一史<br>学位規則第4条第1項該当

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Zeng, Chunxi. "Riboswitch-targeted Drug Discovery: Investigation of Factors that Affect the T Box Transcription Antitermination Mechanism." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1451943674.

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Malvezzi, Alberto. "Modelos de virtual Screening de inibidores da cruzaína: desenvolvimento e validação experimental." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-10082016-115529/.

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Com o objetivo de buscar e identificar novo(s) inibidor(es) da cruzaína uma cisteíno-protease do Trypanosoma cruzi, o agente etiológico da doença de Chagas foram propostos, validados e, a seguir, aplicados sobre a biblioteca de compostos ZINC (3.294.714 compostos), dois modelos de virtual screening (Modelos I e II). Os modelos de virtual screening propostos, contendo seqüências de filtros físicoquímicos, farmacofóricos, de docking e de seleção por inspeção visual, foram construídos a partir de informações de 13 complexos da cruzaína e de 20 complexos de outras cisteínoprotease, cujas estrutu

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32

Lôme, Vincent. "Des agents chimiosensibilisants pour lutter contre la résistance aux antibiotiques chez les bactéries Gram-négatif : criblage et caractérisation." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0063.

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Les bactéries Gram-négatif possèdent une structure d'enveloppe, ainsi que des pompes d'efflux (i.e., systèmes de transport actif permettant de détoxifier la cellule bactérienne) qui les rendent naturellement résistantes aux antibiotiques. Ces deux caractéristiques constituent de véritables barrières qui s'opposent à l'accumulation d'une grande variété d'antibiotiques près de leur cible, à l'intérieur de la bactérie. La perturbation des mécanismes s’opposant à l’accumulation d’antibiotiques par des agents chimiosensibilisants représente une stratégie prometteuse.L’objectif de cette thèse était

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Pérez, María del Carmen Marín. "Benchmarking and applications of a computational photobiology tool for design of novel and highly fluorescent rhodopsin proteins." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1070289.

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In recent years, world economy and technological advancement have been transformed by Genomics, which allows us to study, design and build biologically relevant molecules. Genomics is already deeply embedded in industries as diverse as pharmaceutical, food and agricultural, environmental and bio-tech in general. Fast and cheap tools for gene sequencing, protein expression and analysis are commonly used for high-throughput genomic-related studies. However, due to experimental difficulties and long time scales (e.g., protein crystallization), protein structure determination, and thus the fundam

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Mucs, Daniel. "Computational methods for prediction of protein-ligand interactions." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/computational-methods-for-prediction-of-proteinligand-interactions(33ad0b24-ef7b-4dff-8e28-597a2f34e079).html.

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This thesis contains three main sections. In the first section, we examine methodologies to discriminate Type II protein kinase inhibitors from the Type I inhibitors. We have studied the structure of 55 Type II kinase inhibitors and have notice specific descriptive geometric features. Using this information we have developed a pharmacophore and a shape based screening approach. We have found that these methods did not effectively discriminate between the two inhibitor types used independently, but when combined in a consecutive way – pharmacophore search first, then shape based screening, we h

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Hao, Yanwei. "Auxin-mediated fruit development and ripening : new insight on the role of ARFs and their action mechanism in tomato (S. lycopersicum)." Thesis, Toulouse, INPT, 2014. http://www.theses.fr/2014INPT0094/document.

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L'auxine est une hormone végétale qui coordonne plusieurs processus de développement des plantes à travers la régulation d'un ensemble spécifique de gènes. Les Auxin Response Factors (ARF) sont des régulateurs transcriptionnels qui modulent l'expression de gènes de réponse à l’auxine. Des données récentes montrent que les membres de la famille des ARF sont impliqués dans la régulation du développement des fruits de la nouaison à la maturation. L'objectif principal de la thèse est d’étudier la part qui revient aux ARF dans le contrôle du développement et de la maturation des fruits et d’en comp

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De, Veer Simon J. "Development of novel protease inhibitors for epidermal kallikrein proteases." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/114508/1/Simon_de%20Veer_Thesis.pdf.

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Preserving the integrity of the skin's outermost layer (the epidermis) is vital for humans to thrive in hostile surroundings. Covering the entire body, the epidermis forms a thin but impenetrable cellular cordon that repels external assaults and blocks the escape of water and electrolytes from within. This structure exists in a perpetual state of repair and regeneration where the production of new cellular subunits (keratinocytes) at the base of the epidermis is offset by the gradual release of terminally differentiated corneocytes from the surface. It is increasingly clear that proteinases (h

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Smith, Bryan Ronain. "Nanoparticulate platforms for molecular imaging of atherosclerosis and breast cancer." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1150309580.

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Ceng, Jia-Shao, and 曾嘉卲. "THE DEVELOPMENT OF NOVEL RICE SCREENING MECHANISMS." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/96584468748412361739.

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碩士<br>大同大學<br>機械工程學系(所)<br>98<br>The purpose of this thesis is to develop new modes use other than vibration screen, and its main function is testing for a small amount of rice. It also has the same function and performance with existing vibrating screen machine. Finally in order to combine automated inspection machine, developed a special rice elevator, aimed at connecting the test procedure and selection process in this thesis. In order to reach the function the new screen machine should be have, this thesis will try to experiment and discuss three aspects, namely, photoelectric, wind-type a

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PutraSetyawan, Rendy, and 希主望. "Comparison of Procurement Auction Alternative Mechanisms: Bidder Screening and Contract Incentive." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/234844.

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Hsu, Shuo-Chen, and 許碩辰. "Cytotoxic screening of 2,6-Disubstituted Amidoanthraquinones and Anticancer Molecular Mechanisms Studies." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/78181669452794934138.

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碩士<br>高雄醫學大學<br>藥理學研究所碩士班<br>94<br>In recent years, anthraquinones derivatives have been proved to possess various of biological activities including anticancer: antibacterial, anti-multiple sclerosis, vasodilatation and supperes intestine creeps effects. Our research team has reported that hundreds synthesized small-molecule disubstituted anthraquinones have cytotoxic effects on various cancer cell lines. We found the different of anthraquinone derivatives (1,4 1,5 1,8 and 2,6 disubstituted derivatives) have demonstrated different cytotoxic potency (Huang et al.2001-2006). For investigation

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Su, Chun-Ting, and 蘇峻霆. "Screening of Anti-HSV Agents and Study of Their Antiviral Mechanisms." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/60553137907608451482.

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碩士<br>國立臺灣大學<br>醫事技術學研究所<br>92<br>Herpes Simplex Virus (HSV) types 1 and 2 infections are the cause of cold sores and genital herpes as well as life-threatening or sight-impairing disease mainly in immunocompromized patients, pregnant women and newborns. After primary infections, HSV can establish persistent infection in nervous system and may reactivate intermittently upon appropriate stimuli. Because of the wide popularity, high ability to transmit and the difficulty to develop prophylactic vaccines, development of chemotherapy is comparatively important. To date, the most widely used and su

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Lee, Kao Yuan, and 李高源. "Screening of potential herbal medicines for life extension and investigation of their molecular mechanisms." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/97amgn.

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Lin, Shih-Chao, and 林士超. "Establish a Model for Screening Antiviral Compounds against High Contagious Viruses and Investigating the Underlying Mechanisms." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/kj88an.

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博士<br>國立中興大學<br>醫學生物科技博士學位學程<br>106<br>High contagious viruses can lead to rapid and robust outbreaks, causing heavy casualties worldwide. However, it usually lacks of available vaccine or antiviral drug against these high contagious infections, such as Middle East Respiratory Syndrome coronavirus (MERS-CoV), chikungunya virus, Zika virus, and Venezuelan equine encephalitis virus (VEEV). In contrast to the time-consuming process of discovering and developing new drugs, we attempted to adapt the current natural products, polyphenols, from plants for screening potential antiviral agents. Here, w

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Lai, Yi-Hua, and 賴怡樺. "Establishment of anti-cancer drug screening platforms for lung cancer: The identification of effective drugs and functional mechanisms." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/86hvd5.

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博士<br>國立中興大學<br>分子生物學研究所<br>101<br>High mortality lung cancer is the most frequent cause of cancer deaths worldwide,including Taiwan. Because of cancer cell metastasis, cancer patients have poor prognosis. The process of cancer metastasis, cancer cells via peripheral vascular or lymphatic move to other parts of the division and growth. The process not only regulate tumor suppressor gene or oncogene expression, cancer cells also secrete angiogenic factors to promote angiogenesis and accelerate cancer metastasis. A lot of pharmacologists try to find the answers from the traditional Chinese herb

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Chen, Ju-Ling, and 陳儒伶. "In vitro Constitutive Androstane Receptor (CAR) Activation Screening System Establishment and CAR-activation Mechanisms Study of Coumarin Derivatives." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/56n868.

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Jurke, Clinton J. "Evaluation of components of sclerotinia stem rot (Sclerotinia sclerotiorum) management in canola : seeding rates, avoidance mechanisms, and physiological resistance screening methodologies." 2003. http://hdl.handle.net/1993/19941.

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Chi, Chih-Wen, and 紀智文. "The screening of neuroprotective components against A-beta or glutamate-induced toxicity from Chinese medicine and elucidating the mechanisms of neuroprotection." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/54747542249812614207.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>88<br>英文摘要： For searching the neuroprotective agents against glutamate-induced neurotoxicity, ninety-one fractions of crude extracts from twenty-seven kinds of Chinese herbal medicine were screened by using cortical neurons as model system. The cell viability was determined by MTT reduction assay. The preliminary results showed that the water extraction of Panax ginseng C.A. Meyer and five fractions of water extraction of Origanum vulgare L. were the most effective to reduce the neurotoxicity induced by glutamate. The mechanisms of neuroprotective effect

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Wang, Shaoyu. "Structure-activity screening of platinum intercalators and molecular mechanisms for the cytotoxicity of 56MESS - [Pt(5,6-Dimethyl-Phen)(1S,2S-DACH)]²⁺." Thesis, 2011. http://handle.uws.edu.au:8081/1959.7/506756.

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Efficacy of existing clinical anticancer drugs including cisplatin and its analogues is greatly limited by drug resistance and side effects. Anticancer compounds with novel structures and different mechanisms of action have been sought to expand anticancer activity and to minimise these limitations. First part of this project evaluated the structure-activity relationships for a class of novel platinum metallointercalators using cytotoxicity screening against cancer cell lines, and subsequently identified lead compounds. Second part elucidated the biological mechanisms underlying the cytotoxic

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Li, Liao. "Chemical Forays of Fungal Metabolites." Phd thesis, 2018. http://hdl.handle.net/1885/148782.

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This thesis contains six chapters and the research presented within focuses on three parts. The first part (chapter one to three) was the isolation of antibacterial and antioxidant mushroom metabolites, and the synthesis towards analogues of discovered natural products. The following part (chapter four) was to assess antioxidant activities of synthetic compounds and investigate their SAR (structure-activity relationship), by use of a developed DPPH assay. The last part (chapter five to six) was the discovery of an abiotic halogenation reaction among a class of fungal metabolites, azaphilones.

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Yuan-ShuoHsueh and 薛元碩. "Establishment of a Drug Screening Platform to Study the Effects and Mechanisms of Tyrosine kinase Inhibitors and a Novel HSPAA1 Inhibitor (NVP-AUY922) on Mutant KIT-expression GIST." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/39080318730110331378.

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博士<br>國立成功大學<br>臨床藥學與藥物科技研究所<br>101<br>Background Advanced gastrointestinal stromal tumors (GIST), a KIT oncogene-driven tumor, on imatinib mesylate (IM) treatment may develop secondary KIT mutations to confer IM-resistant phenotype. Second-line sunitinib malate (SU) therapy is largely ineffective for IM-resistant GISTs with secondary exon 17 (activation-loop domain) mutations. Nowadays, several KIT tyrosine kinase inhibitors (TKIs) and heat shock protein 90 (HSP90AA1) inhibitors are under investigation for IM and/or SU-resistant GIST patients. However, there is no notable improvement. In this

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