Teses / dissertações: "Schizophrenia"

1

Aguilera, Adrian. "Acculturation and family factors in the course of schizophrenia". Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1872911411&sid=4&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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2

Beedie, Sara A. "Atypical viewing behaviour in schizophrenia". Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=26092.

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3

Marschinke, Kathleen. "Family interventions in the treatment of schizophrenia". Online version, 1999. http://www.uwstout.edu/lib/thesis/1999/1999marschinkek.pdf.

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4

Chan, Wing-leung. "Caregiving for people with schizophrenia in Guangzhou : coping, adaptation and quality of life /". Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B2337326x.

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5

Flexer, Michael James. "The Schizophrenic Sign : a dialectic of semiotics and schizophrenia". Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15282/.

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This thesis posits as its central argument that placing semiotic theory in dialectic with the discourses of and about ‘schizophrenia’ will produce novel insights into both. Simultaneously, this thesis develops a semiological sign system for ‘schizophrenia’, mapping and critiquing its central narratives, organising ethics, aesthetics and thematics, whilst also offering a practical model as exemplar for a semiotic method of cultural, textual, medical, psychological and social critical analysis. In so doing, this thesis presents and develops the concept of ‘schizomimesis’, a term to describe the process by which the discourse and semiological sign system of ‘schizophrenia’ adopts formal qualities that mimetically embody the ‘disease’ symptomatology. The thesis explores this idea, placing different ‘symptoms’ in dialectic with different discourses: thought insertion, influence and the instability of signs in relation to diagnostics and aetiology; ‘psychotic’ speech and so-called thought disorder; distrubances of ipseity and magical thinking in narrative medicine and illness memoirs; hallucinations and delusions of reference in popular cinematic and televisual representations; deictic crises in the person, in the therapeutic process, and across popular culture and society. Throughout, the thesis constructs a de-psychologised and socialised, inter-subjective model of the self, inseparable from the dynamic of indivisible sign relations, and strives to understand ‘schizophrenia’ within this conceptual context. This thesis thereby offers a model of how medical humanities research can contribute evenly to the discplines from which it draws its materials and methodologies. At the same time, it hopes to offer humane and thoughtful observations on the personal, cultural, medical and social disadvantages and difficulties, and highly idiosyncratic experiences, endured by those with lived experience of ‘schizophrenia’.

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6

Breitborde, Nicholas Joseph Kachagian. "Family factors and schizophrenia measurement, mechanisms, and consequences for caregivers /". Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1472131481&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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7

Seher, Marizita. ""Victimless" behavioral management of schizophrenia within the family environment". View full text, 2003.

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8

Hogh, Theresa. "Psychotrope Arzneimitteltherapie und deren Kosten für schizophren erkrankte Menschen in Frankreich, Deutschland und Großbritannien". Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-100278.

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Schizophrenie ist eine schwere und zumeist chronisch verlaufende psychiatrische Erkrankung und stellt eine enorme finanzielle Belastung für das Gesundheitssystem dar. Daten zu den medikamentösen Kosten liefern Hinweise zur Verbesserung der Kosteneffektivität innerhalb der Patientenversorgung. In der vorliegenden Arbeit erfolgt eine Analyse der internationalen Unterschiede im Arzneimittelverbrauch und der Kosten der psychotropen Medikation im Rahmen der Behandlung von schizophren Erkrankten. Die Analyse basiert auf Daten aus einer naturalistischen, prospektiven Längsschnittstudie über einen Zeitraum von zweieinhalb Jahren (European Schizophrenia Cohort) in den Ländern Frankreich, Deutschland und Großbritannien. Ausgangspunkt der multivariaten Regressionsanalyse ist die Vermutung, dass die Höhe der Kosten in der medikamentösen Therapie von folgenden soziodemografischen Eigenschaften schizophren Erkrankter beeinflusst werden: dem Alter, klinischen Status, Geschlecht und der Zahl der vorangegangenen stationären Aufenthalte. Es ist festzustellen, dass es internationale Unterschiede im Medikamentenverbrauch gibt. Unterschiede in der Erstattungsfähigkeit, vorhandene Arzneimittelbudgets, verschiedene Behandlungsleitlinien und Verschreibungspraxen sind mögliche Erklärungen. Es wird gezeigt, dass ein an Schizophrenie erkrankter Patient in Deutschland signifikant höhere Arzneimittelkosten bei gleicher Therapie verursacht. Das ist möglicherweise durch die unterschiedlichen Gesundheitssysteme mit den unterschiedlichen Einflussnahmen des Staates auf die Pharmaindustrie zu erklären. Die Variablen Herkunftsland, Alter und Krankheitsschwere beeinflussen die Höhe der Kosten der medikamentösen Therapie.

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9

Niehaus, Daniel Jan Hendrik. "Subtyping schizophrenia". Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86221.

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Thesis (PhD)-- Stellenbosch University, 2014.
ENGLISH ABSTRACT: Schizophrenia is a phenotypically heterogeneous disorder believed to have a strong genetic component. Limiting its clinical heterogeneity by means of subtyping may help to shed light on some of the genetic underpinnings of the disease. This study describes the application of factor analysis (FA), latent class analysis (LCA) and factor mixture modeling in a sample of 734 Xhosa-speaking schizophrenic subjects using factor analytically derived variables previously identified in an independent sample of this population. LCA was performed on the following 8 SANS and SAPS items identified by preliminary exploration of the data: eye contact, auditory hallucinations, global hallucinations score, global delusions score, grooming, affective non-responsiveness, spontaneous movement, and commenting voices. A four class model provided the best fit. Classes 1 and 2 were characterized by predominantly positive and predominantly negative symptoms, respectively, class 3 by both positive and negative symptoms and class 4 by few or absent symptoms. A history of cannabis use or abuse increased the probability of a subject being allocated to class 1, while being male made a person more likely to be included in class 2. Factor mixture modelling was performed by first using latent class analysis, then factor analysis and then the factor mixture analysis were done. The fit among these three types were then investigated. The results show that factor mixture modelling uncovered a heterogeneous latent variable structure that fits the data well with the latent classes capturing distinct positive symptom/behaviours and factors capturing severity variations. This study, the first to report on the latent class structure of schizophrenia in a sample of patients from a sub-Saharan African population, supports the universality of specific latent classes across ethnic boundaries. The results further support reports that gender, sibpair status and cannabis use may influence the phenomenology of schizophrenia. The identification of subgroups may represent an intermediate step in the search for endophenotypes of schizophrenia.
AFRIKAANSE OPSOMMING: Skisofrenie is „n psigiatriese steuring met „n heterogene fenotipe en „n vermoedelik sterk genetiese vatbaarheid. Ten einde die lig te werp op die genetiese onderbou van skisofrenie word gepoog om die kliniese heterogenisiteit te beperk deur middel van subgroepering. Hierdie studie beskryf die gebruik van latente klas analise (LKA) in „n groep van 734 Xhosa-sprekendes met skisofrenie. Die LKA word baseer op die gebruik van veranderlikes wat deur middel van faktor analise op simptome in „n onafhanklike studiegroep van Xhosa-sprekendes met skisofrenie verkry is. Die LKA is gedoen op die volgende 8 “SAPS” en “SANS” veranderlikes wat deur voorlopige ondersoek van die data ge-indentifiseer is: oogkontak, gehoorshallusinasies, globale hallusinasie telling, globale waantelling, selfversorging, affektiewe nie-responsiwiteit, spontane beweging en stemme wat kommentaar lewer. „n Vierklas oplossing het die beste passing getoon. Klas 1 en 2 is gekenmerk deur oorwegend positiewe en negatiewe simptome onderskeidelik, klas 3 het beide positiewe en negatiewe simptome gehad en klas 4 het baie min of geen simptome getoon nie. „n Geskiedenis van kannabis gebruik of misbruik het die kans verhoog dat die individue in klas 1 gevind sou word, terwyl manlike geslag as veranderlike die kanse verhoog het vir allokasie in klas 2. Faktor mengsel modelering is gedoen deur eers „n latent klas analise te voltooi, gevolg deur „n faktor analise, en laastens „n factor mengsel analise. Die passing tussen die drie analises is daarna evalueer. Faktor mengsel modelering toon „n heterogene latente klas struktuur wat voldoen aan die passingsvereistes. Die latente klasse blyk spesifieke positiewe simptome/gedrag te verteenwoordig, terwyl die factor grad van erns variasie aandui. Hierdie studie is die eerste om die latente klas struktuur van skisofrenie in „n subsahara-Afrika populasie, die Xhosa, te beskryf. Die resultate onderstreep die universialiteit van die latente struktuur van skisofrenie se simptome oor etniese grense heen. Verder ondersteun die resultate die moontlike rol van geslag, aangetaste sibstatus en kannabis gebruik in skisofrenie se fenomenologie. Die identifisering van die subgroepe mag „n intermediêre stap in die soektog vir endofenotipes van skisofrenie verteenwoordig.

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10

Schock, Sandra Lynn. "Difficulties in psychotherapy with a residual schizophrenic". Thesis, Rhodes University, 1991. http://hdl.handle.net/10962/d1007457.

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This work addresses some of the difficulties encountered while working in psychotherapy with a residual schizophrenic. While there is an abundance of literature on psychotherapy for schizophrenia, both supporting and also refuting its merit, what the literature fails to reveal is that there appears to be a class of schizophrenic who, while apsychotic and able to communicate in the everyday sense of the word, is in a psychic space which speaks of a break with the basic relational elements of the human order. The quality of the patient's psychic life is such that almost nothing of what the literature describes as useful and appropriate in working with schizophrenics seems to help in the psychotherapeutic work with this type of patient. This study describes these issues with relevance to a particular residual schizophrenic. The Illustrative-didactic case-study method was used to discuss the four-and- a-half month psychotherapy with this patient. The patient's early developmental history, premorbid personality functioning, family and interpersonal relationships, mental state, diagnosis and a rationale for psychotherapy were presented and considered in detail. The structure of the psychotherapeutic process was reviewed in depth. The hermeneutic guidelines to understanding the case were drawn from Object-Relations Psychoanalytic theory, particularly Balint, Khan, Karon & VandenBos, Bollas, Romanyshyn, Perry, Symington, Fordham and others. Various psychic and personality features, as unveiled through the psychotherapeutic process, were elaborated and the implications of these for the therapeutic endeavour were considered as follows: Firstly, the psychic space of the patient, which precluded mirroring, symbolization find object-relationship - and which made psychotherapy untenable, was discussed. Secondly, therapeutic ambivalence and other counter-transference issues were reviewed. Thirdly, the shadow sides of both therapeutic optimism and of psychotherapeutic change were considered. Fourthly, the issues of therapeutic failure and of other treatment possibilities for a residual schizophrenic patient were examined. It was concluded that there needs to be an important countertransference shift with regard to the psychotherapeutic goals for those patients whose condition may be chronic, and for whom it appears that psychotherapy is not going to be of any therapeutic benefit - find where an 'empathic accompaniment' might be as much as it is possible to hope for or achieve.

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11

Franco, Michelle E. "A behavioral treatment program for chronic schizophrenics". Scholarly Commons, 1997. https://scholarlycommons.pacific.edu/uop_etds/2305.

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I examined the effects of a residential treatment program on symptoms and mental health service use in 14 chronic schizophrenics. The clients chosen for this study were the most difficult clients in this population due to continued high service usage (i.e., time spent in locked facilities). All 14 clients had been in a locked facility at least 1 year immediately prior to treatment. The program included skills training, reinforcement for incompatible behavior, and a token economy. The clients' symptomology was recorded twice a day. My hypotheses were that symptoms would decrease due to the program, and clients mental health service use would also decrease in a 1 year follow-up. Mental health service use (time spent in a locked facility) did decrease dramatically after treatment. All 14 clients had a decrease in the amount of time spent in locked facilities after treatment. The total cost for these clients in locked facilities the year immediately prior to treatment was conservatively estimated at $776,500. The annualized figure of the total cost of these 14 clients after treatment was estimated at $44,775, saving San Joaquin County approximately $721,725 in 1 year. The results did not support the hypothesis that the program reliably decreases schizophrenic symptomology as we measured it.

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12

Wade, Tracey. "Factors contributing toward vulnerability to relapse for people with a diagnosis of schizophrenia". Thesis, Canberra, ACT : The Australian National University, 1992. http://hdl.handle.net/1885/141362.

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13

Lee, Heeyoung. "Protective and risk factors in adolescents with schizophrenia /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7263.

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14

Nichols, Fiona Erica. "Inside Schizophrenia: Mending the Internal Conflict; And, The Historical, Cultural and Social Aspects of Schizophrenia". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/548.

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This thesis comprises a memoir and essay on schizophrenia. It is estimated that 285,000 people suffer some form of schizophrenia in Australia. This means, on average, one in seventy people in Australia suffer from the disorder. For males, schizophrenia often develops in early adulthood. For females, it has later onset. There are about five types of schizophrenia: paranoid, catatonic, disorganised, undifferentiated, and residual. The focus of this thesis is on the diagnosis of Paranoid Schizophrenia. There is no cure, but it is treatable. However, people with a treatment resistant schizophrenia can find life difficult. The aim of the thesis is to inform people that it is not a condition to fear, and to dispel the stigma often associated with mental illness. Many people shy away from schizophrenics, as the impression given by media is that schizophrenics are dangerous. Another common myth is that schizophrenics have ‘split personality’, which is not the case. The symptoms do not involve multiple personalities. Schizophrenia derives from the Greek, meaning ‘split mind’, and this is where the myth has originated. The focus of the essay is on the historical, cultural and social aspects of schizophrenia. The term schizophrenia was coined in the early twentieth century. The essay looks at ancient texts, where schizophrenia possibly originated in early forms of psychosis. It also considers other cultures, in many of which schizophrenia is stigmatized. Through demystification, the thesis aims to show that it is a medical complaint, rather than a spiritual one. Social aspects include the need for more community support for schizophrenics. This thesis will, hopefully, help to facilitate greater understanding of the condition by providing a personal perspective.

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15

Chin, Sammantha. "The Conceptualization of Schizophrenia by Siblings of Individuals with Schizophrenia". Thesis, Roosevelt University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10750967.

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The purpose of this qualitative study was to understand how siblings of individuals with schizophrenia understand the symptoms and problems that an individual diagnosed with schizophrenia experiences. Although there is, as of yet, no consensual model of normalcy or of psychopathology, models are important because they have implications for clinical practice. In regards to schizophrenia specifically, clinicians and researchers have asserted the importance of the family in the development and course of the disorder. Siblings may offer a unique viewpoint as they may experience or have experienced sub-clinical schizophrenia-related symptoms themselves.

Five individuals who have a sibling diagnosed with schizophrenia were interviewed about how they conceptualize their siblings’ experiences and problems. The interviews were analyzed with Interpretative Phenomenological Analysis. A total of sixteen emergent themes from the interviews are discussed, some of which include very different, still the same; struggle to understand; “that thing;” “vigilant, careful, cautious;” still love and care; and alienation from self and others. Several components of the themes indicate that participants had both a categorical and a dimensional model of their siblings’ problems. Future research regarding gaining a greater understanding of how people conceptualize the problems and experiences of those diagnosed with schizophrenia and clinical applications are also discussed.

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16

Martin, Jean-Remy. "Schizophrenia and metacognition". Phd thesis, Université Pierre et Marie Curie - Paris VI, 2014. http://tel.archives-ouvertes.fr/tel-01020826.

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Over the course of my PhD I have investigated issues related to two main areas of investigation in cognitive science, namely Schizophrenia and Metacognition. My dissertation is divided in two parts: the first part includes three experimental studies (two studies in healthy subjects and one study in people with schizophrenia) and two theoretical studies addressing specific aspects of schizophrenia; the second part includes four theoretical studies addressing the role of metacognition in specific debates in philosophy and cognitive science of perception. I have explored two symptomatic expressions of schizophrenia, thought insertion and experiences of activity, as well as a potential cognitive bias, namely the potential presence of perceptual persistence biases. With respect to metacognition, I have investigated ways in which consideration of the role of metacognitive feelings (the experiential output of metacognitive processes) could shed new light on important current debates in analytical philosophy and cognitive science. The issues I have focused on are: the problem of hallucinations, the debate about cognitive penetrability (i.e., whether or not higher-order cognitive states may influence perceptual processes), the perception of absences and sensory substitution.

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17

Grinko, Natalia. "PSYCHOEDUCATION FOR SCHIZOPHRENIA". Thesis, Вищий державний навчальний заклад України «Буковинський державний медичний університет», 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/15611.

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18

Ericksen, Glenda Joy. "Schizophrenia in childhood". Master's thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/25850.

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The diagnosis of Schizophrenia in children has historically been the source of much psychiatric controversy, especially with regard to classification, treatment and prognosis. This was further complicated by the broad category for the diagnosis of psychotic disorders in childhood in the Diagnostic and Statistical Manual of Mental Disorders (DSM 11).This included Schizophrenia in childhood, autism, and other psychotic conditions. The work of Kolvin (1971 a-f) and Rutter (1972), have been instrumental in separating autism and Schizophrenia into distinct categories. This review is not aimed at being an exhaustive coverage of all the literature on Schizophrenia in childhood, but is focused on classification, phenomenology, epidemiology, differential diagnosis, etiology, course, cross-cultural factors, and treatment. The adult literature has been referred to, when there is no appropriate reference in the literature on children with Schizophrenia, in certain focused areas. Specific research questions will be discussed in depth in the appropriate sections. These are: 1) Is Schizophrenia with childhood onset a discretely homogenous entity or is the condition on a continuum with adult Schizophrenia? 2) Are the current classification systems diagnostically valid in children with Schizophrenia? 3) Do phenomenological descriptions of the condition assist the clinician diagnostically, given the financial constraints limiting the extent of special investigations, in the South African context? 4) The evidence concerning the etiology of Schizophrenia in childhood will be critically evaluated. 5) Do current treatment models have any relevance to clinical practice in South Africa, especially with regard to the need for cost-effective solutions? 6) Two cases obtained from the in-patient Unit of the Red Cross Hospital's Child and Family Unit will also be examined, in the light of the literature. As much of the literature prior to DSM III generally did not clearly differentiate between childhood Schizophrenia, autism and other heterogeneous conditions (Rutter, 1972), they have not been included, except for seminal papers. In addition the age groups in the papers do not always mention the pubertal status of the children, thus for the purpose of the review, primarily studies focusing on samples with onset prior to 13 years are included. These have lately been characterized in the literature as 'VEOS' (Very Early Onset Schizophrenia). In one of the few longitudinal studies of children with Schizophrenia, Werry, McClellan and Chard (1991), reported that more than half the sample (55%) which had been diagnosed as schizophrenic at first presentation, was found to have Bipolar Disorder at follow-up. It is possible that the papers reviewed may also reflect this once longitudinal follow-up has been completed. The results of longitudinal studies are awaited.

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19

Kalathil, Mohammed Shakeel. "Confabulations in Schizophrenia". Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1413301224.

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20

Ferriter, Michael Charles. "Parenting and schizophrenia". Thesis, Swansea University, 1997. https://cronfa.swan.ac.uk/Record/cronfa42329.

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The first part of this study reviews the evidence for biological, vulnerability-stress and psycho-social models of Schizophrenia focusing on the latter, particularly on pathogenic parenting models. The reasons why, despite lack of evidence, pathogenic parenting models gained the popularity they did are explored, including mental disorder as a disorder of mind rather than body, the claims of non medical professions to treat mental disorder, issues of therapeutic optimism and pessimism and political and social factors, including the status and societal view of women in general, and mothers in particular. In the second part of the thesis the existing literature on the plight of the parents of people with Schizophrenia is reviewed. The author conducted in depth interviews with parents of thirty persons with Schizophrenia (patients in a forensic or a community setting) looking at three main areas: subjects' views on the aetiology of Schizophrenia, burden and stress, and encounters with mental health care professionals. The subjects discounted pathogenic parenting models. However, significant levels of feelings of "guilt" for causing the disorder were recorded. High levels of stress and burden were found. Levels of contact with professionals were low and professionals were poor at information giving. However, levels of blaming by professionals were lower than expected with almost as many instances of professionals counselling parents not to blame themselves. The seemingly paradoxical results of discounting pathogenic parenting models, low levels of professionals blaming and nearly equal levels of overtly non-blaming, yet high levels of guilt are best explained by Attribution Theory. The author concludes that this may also explain more recent, disappointing, findings on the impact of family psychoeducational programmes and argues that the lessons of Attribution Theory in other contexts should be taken into account when designing such interventions.

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21

Ho, Wing Nan Winnie. "Recovery model among Chinese people with schizophrenia". HKBU Institutional Repository, 2008. http://repository.hkbu.edu.hk/etd_ra/987.

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22

Barker, Sarah C. "Narratives on the course of schizophrenia : client and family reflections on process and the impact on self". n.p, 1998. http://ethos.bl.uk/.

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23

Edwards, Kimberly. "Patterns of Change in Semantic Clustering in Schizophrenia Spectrum Disorders: What Can it Tell Us about the Nature of Clustering Deficits". Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc2906/.

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Semantic clustering has been used as a measure of learning strategies in a number of clinical populations and has been found to be deficient in individuals with Schizophrenia, but less attention has been paid to the dynamic use of this strategy over the course of fixed-order learning trials. In the current study, we examined this pattern of clustering use over trials in a sample of individuals with Schizophrenia, and explored whether the addition of this dynamic information would help us to better predict specific executive deficits. Results suggested that a decrease in semantic clustering across trials was associated with some executive deficits in the predicted manner. Nonetheless, the overall semantic clustering index generally proved more effective for the purposes, suggesting that in this population, the addition of dynamic information in strategy use is not likely to add considerably to clinical prediction and understanding.

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24

Martin, Jennifer Lynn. "Aging and sleep in schizophrenia patients and normal comparison subjects : subjective reports and objective findings /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3049676.

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25

Brown, Kerri J. "Beyond the P300 target and non-target ERP components in schizophrenia /". Access electronically, 2004. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20050218.140514/index.html.

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26

Hall, Janice Anne Crawford. "The Assessment of Cognitive Functioning of Persons with Schizophrenia: Identification of Neuropsychological Markers". Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc278218/.

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27

Reuter, Cora L. "Perceptions of schizophrenia and educational recommendations how to break the stigma /". Menomonie, WI : University of Wisconsin--Stout, 2007. http://www.uwstout.edu/lib/thesis/2007/2007reuterc.pdf.

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28

Cantor-Graae, Elizabeth. "Neurodevelopmental aspects of schizophrenia". Lund : Dept. of Psychology, Lund University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39749040.html.

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29

Green, Asha M. "Participant Perspectives: Investigating the Experience of Low-Income Schizophrenics in Clinical Research Trials". Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc799519/.

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The continued investigation into the experiences of individuals with schizophrenia who participate in biomedical research trials is necessary in order to understand participants’ perspectives, motivations, attitudes, values, and beliefs. As important stakeholders in the clinical research process, participant feedback is significant and can help shed light on, not only their experiences, but also deepen understandings when it comes to clinical trial participants’ perceptions of informed consent and personal autonomy. Conducting ethical research demands the exploration of these issues and specifically targeting this vulnerable group helped to address a gap in the literature. This study was conducted for InSite Clinical Research and gathered data in the form of in-depth semi-structured interviews and a short survey instrument with 20 low-income adults diagnosed with schizophrenia that participate in clinical research trials. Findings indicate overall positive research experiences, with motivations aligning with previous research when it comes to trial participation including: altruism, personal benefit, access to medications, financial incentives, and psychosocial treatment. Learning about their illness and themselves, autonomy, and debriefing were also particularly important within this group. Unique to this sample were findings of friendship. Trust in the research staff was identified as a major underlying value and shaping factor impacting informed consent decisions. These conclusions have implications for recruitment and informed consent practices at InSite Clinical Research.

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30

McGrath, John Joseph. "The epidemiology of schizophrenia /". [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17061.pdf.

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31

Åberg, Karolina. "Finding Genes for Schizophrenia". Doctoral thesis, Uppsala universitet, Evolutionsbiologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5894.

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Schizophrenia is one of our most common psychiatric diseases. It severely affects all aspects of psychological functions and results in loss of contact with reality. No cure exists and the treatments available today produce only partial relief for disease symptoms. The aim of this work is to better understand the etiology of schizophrenia by identification of candidate genes and gene pathways involved in the development of the disease. In a preliminarily study, the effects of medication and genetic factors were investigated in a candidate gene, serotonin 2C receptor. This study distinguished pharmacological effects, caused by neuroleptics, and/or genetic effects, caused by unique polymorphisms, from other effects responsible for mRNA expression changes on candidate genes. The core of the thesis describes a new candidate gene for schizophrenia, the quaking homolog, KH domain RNA binding (mouse) or QKI, located on chromosome 6q26-q27. The identification of QKI is supported by previous linkage studies, current association studies and mRNA expression studies using three different sample sets. The investigated samples included a 12-generation pedigree with 16 distantly related schizophrenic cases and their parents, 176 unrelated nuclear families with at least one affected child in each family and human brain autopsies from 55 schizophrenic cases and from 55 controls. Indirect evidence showing involvement of QKI in myelin regulation of central nervous system is presented. Myelin plays an important role in development of normal brains and disruption of QKI might lead to schizophrenia symptoms. In a forth sample set, including extended pedigrees originated from a geographically isolated area above the Arctic Circle, in northeast Sweden, two additional schizophrenia susceptibility loci were identified, 2q13 and 5q21. Both these regions have previously been highlighted as potential schizophrenia loci in several other investigations, including a large Finnish study. This suggests common schizophrenia susceptibility loci for Nordic populations. A pilot investigation including a genome wide haplotype analysis is presented. This statistical strategy could be further developed and applied to the artic Swedish families, including analysis of 900 microsatellites and 10,000 SNPs. These findings will facilitate the understanding of the schizophrenia etiology and may lead to development of more efficient treatments for patients that suffer from schizophrenia.

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32

Humphries, Clare Ruth. "Gene expression in schizophrenia". Thesis, Imperial College London, 1997. http://hdl.handle.net/10044/1/7770.

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Gasbarre, Lisa Maria. "Neurocognitive functioning in schizophrenia". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0023/MQ31348.pdf.

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Krupa, Teresa M. "Work recovery in schizophrenia". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ49899.pdf.

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Miscio, Gina. "Aging women with schizophrenia". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ55919.pdf.

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Åberg, Karolina. "Finding genes for schizophrenia /". Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5894.

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Hempel, Roelie Janneke. "Affect regulation in schizophrenia". [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/12620.

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Wood, Graham. "Neurodevelopmental models of Schizophrenia". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18659.

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Despite the obvious problems of modeling a disorder that is characterized by deficits in higher cognitive functions in lower animals, animal models of schizophrenia have aided in the advancement of the developmental hypothesis of schizophrenia. In fact, using three different animal models of schizophrenia, two of which we developed in our laboratory, we have been able to add support to the hypothesis. First, using NCAM knockout mice, which completely lack the neurodevelopmental molecule PSA-NCAM, we established the first genetic model of schizophrenia that not only presents with sensorimotor gating deficits but ventricular enlargement, both of which have been repeatedly demonstrated in schizophrenics. Next, we used neonatal Endo-N injections to enzymatically remove PSA from NCAM to demonstrate that only a brief disruption of neurodevelopment if sufficient to cause dopaminergic hyper-responsiveness. Finally, while trying to establish a genetic marker for the strain specific vulnerability to neonatal ventral hippocampal lesions (nVH) in Fisher and Lewis rat, we in fact discovered that the vulnerability is solely due to environmental factors, namely, the frequency of arched back nursing (ABN). Then making use of the variation in ABN in Sprague Dawley rats we established a new model in which nVH lesioned rats are separated into groups raised by dams with a High or Low frequency of ABN. Using this model, we demonstrated that the early environment is leading to disruption of the medial prefrontal cortex (MPFC), as characterized by working memory deficits, lack of MPFC control of locomotion and decreased anxiety, only in nVH lesioned rats raised by High ABN dams. Furthermore, we established that the early environment is not leading to sparing of function of the VH since nVH lesioned rats raised by both High and Low ABN dams have deficits on reference memory. Therefore, we have confirmed that genetic factors can lead to deficits in neurodevelopment that cause deficits pa
Malgré les difficultés apparentes liées à la modélisation d'un trouble mental caractérisé par une déficience au niveau des fonctions cognitives supérieures chez les espèces inférieures, la modélisation animale de la schizophrénie a permis des avancements quant aux hypothèses proposées sur le développement de la schizophrénie. En effet, en faisant appel à trois différents modèles animaux de schizophrénie, lesquels furent conçus dans nos laboratoires, nous avons su renforcer ces hypothèses. D'abord, en utilisant des souris mutantes N-CAM, lesquelles présentaient une absence totale de molécules neurodéveloppementales PSA-N-CAM, nous avons mis au point le premier modèle de schizophrénie présentant non seulement des déficiences de filtrage sensoriel, mais aussi une hypertrophie ventriculaire, deux éléments fréquemment observés chez les schizophrènes. Ensuite, nous avons fait appel à des injections Endo-N afin de scinder enzymatiquement l'isoforme PSA de la N-CAM, dans le but de démontrer qu'une simple perturbation même très brève du développement neurologique est suffisante pour engendrer une hyperréactivité dopaminergique. Enfin, en tentant d'établir un marqueur génétique pour la souche déterminée de vulnérabilité aux lésions néonatales de l'hippocampe ventral (nVH) chez les rat Fisher et Lewis, nous avons en fait constaté que la vulnérabilité était dû strictement à des facteurs environnementaux, à savoir, la fréquence d'allaitement avec le dos arqué (ABN). En faisant appel à la variation au niveau du ABN chez des rat Sprague Dawley, nous avons pu établir un nouveau modèle dans lequel des souris furent divisées en groupes de mères faisant souvent usage ou non de l'allaitement avec le dos arqué. Par le biais de ce modèle, nous avons pu démontrer que le premier environnement peut mener à une perturbation du cortex médial préfrontal (CMPF), caractérisée par la perte de mémoire opérationnel

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Archer, Jacqueline. "Face processing and schizophrenia". Thesis, Lancaster University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337662.

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Kennedy, Nigel Iain. "Susceptibility genes for schizophrenia". Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428488.

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Wong, Ting-ting Natalie. "Sustained attention in schizophrenia". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B29727686.

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Kalaitzaki, Argyroula E. "Schizophrenia and family relationships". Thesis, University of Sunderland, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416789.

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Boyle, Mary. "Schizophrenia : a scientific delusion?" Thesis, University of East London, 1988. http://roar.uel.ac.uk/1268/.

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The validity of claims made about 'schizophrenia' (that it is a scientific concept and that it refers to a syndrome) was assessed in three analyses: of the writings of those said first to have described schizophrenia; of the development of rules for inferring schizophrenia and of 'genetic' research said to be central to the concept's theoretical network. Four major conclusions were drawn: 1. That there was no evidence to support the original introduction of 'schizophrenia', but good evidence that some of the population from which it was derived were suffering from a later-identified neurological disorder. 2. That the rules for inferring schizophrenia have been developed in a manner quite different from the development of concepts in the empirical sciences and in medicine. 3. That there is no evidence that the rules set out in DSM-111 refer either to a syndrome or to any pattern of phenomena and 4. that 'genetic' research has been seriously misrepresented in secondary sources and does not support 'schizophrenia'. A number of factors were discussed as possibly important in explaining the continued use and influence of ‘schizophrenia'. These included the use of popular but fallacious types of argument to defend the concept, the functions it apparently serves for psychiatry and the public, the perceived primacy of biological or dispositional explanations of behaviour and the habits of 'seeing' patterns in unrelated phenomena, of inferring before describing, of reifying constructs and of confusing observation and inference. Finally, the implications of abandoning 'schizophrenia' were discussed and the weak foundations of the distinctions between 'normal, and abnormal' behaviour emphasised. An alternative framework, derived from the experimental analysis of behaviour was suggested and illustrated, both for the analysis of bizarre behaviour and of the conditions under which it is seen as symptomatic of schizophrenia.

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Yotis, Lambros. "Dramatherapy performance and schizophrenia". Thesis, University of Hertfordshire, 2002. http://hdl.handle.net/2299/14072.

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This research project examines the impact of therapeutic performance-making within Dramatherapy practice for clients with schizophrenia. 'Dramatherapy Performance', a specific model of therapeutic work which is defined and presented here, consists of the clients' construction of a performance through a therapeutic process and its presentation to an invited audience of their Significant Others. The context of existing evaluation methods in Dramatherapy concerns either the development of the clients' abilities within a group process, such as role-playing or dramatic involvement, or the change of the clients' symptoms after a groupwork as measured by existing psychometric scales. However, no specific method of evaluation of performance-making to be used within clinical practice has been constructed yet. For this reason a new instrument for evaluating this model of work was formulated, namely the 'Dramatherapy Performance Evaluation', which derives from a combination of psychiatric and theatre semiotics. This instrument is inspired by Aristotle's 'Poetics', used for the first time for assessment in Dramatherapy and analyses the structural elements of a performance in relation to the clients' schizophrenic psychopathology. Furthermore, this project examines the effect of a 'Dramatherapy Performance' on the clients' overall psychopathology, and their relationship to self and others. A clinical trial conducted in a Day Hospital for young adult clients with schizophrenia allowed a qualitative evaluation of the therapeutic process as well as quantitative measurements of the clients' symptom change. The outcomes of this project suggest that 'Dramatherapy Performance' has a significant effect on the clients' dramatic involvement within the group process, on the decrease of their overall 'negative symptomatology', on increasing their 'competence and efficacy' and on changing their perceived support from their significant others. The 'Dramatherapy Performance Evaluation' showed the importance of the performance's unifying cathartic structure as well as demonstrating how non-verbal therapeutic processes reinforce the impact of verbal processes. It also distinguished the usefulness of collective techniques - such as participation in a chorus - for the less functional clients as opposed to character work for the more functional clients. This research confirms the value of 'Dramatherapy Performance' as a treatment for specific schizophrenic symptoms, in addition to medication, and provides Dramatherapy practice with a new and useful instrument for the evaluation of both the therapeutic process and the progress of clients with schizophrenia.

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45

Broks, Paul. "Hemisphere asymmetries in schizophrenia". Thesis, University of Oxford, 1987. http://ora.ox.ac.uk/objects/uuid:d724a3b5-fce5-4ae0-9db7-a583b625754a.

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Previous research into everyday conception of personal relationships has been sparse and fragmented, and the various specialisms fail to deal with the broader issue of interpersonal understanding. Following review of the research and theoretical background, with particular reference to changing paradigms, a holistic approach is proposed for an exploration linking the content of explanation and reflection about relationships with the incidence of conceptualising. The methodology, employing content analysis, illustrative studies and a musical analogue, is outlined. Initially focusing on verbalised conception in the form of accounts, a procedure of 'simulated correspondence with a confidant' was employed to facilitate unrestricted disclosures in general descriptions of relationships. Three coding schemes were devised for content analysis of accounts (and for independent use in subsequent research). These pertained to: (1) specific concepts and themes; (2) explanation of interpersonal effect and significance; and (3) intersubjectivity in accounts. Overall indications from the content analyses are that accounts are characterised by superficiality of detail and insight, and concentrate more on basic viability, and on social and visible aspects of personal relationships than on intimate and psychological aspects. The limitations of content analysis, and the deficiencies disclosed, suggest attention should be given to omission in content as much as inclusion, and also to the prior issues of motivation and the extent of relationship "mindfulness". A musical analogy (with particular reference to representation, knowledge and appreciation) is employed to advance the exploration beyond the linguistic aspects of conception to a more general model of relationship awareness. A second set of studies turn to (1) the frequency and occasioning of reflection on relationships; (2) reappraisal over time; (3) interest in relationships compared with other subjects of general interest; and (4) factors which disincline conscious relationship deliberation and analysis. There are indications throughout of a sex difference, with men as less reflective, less inclined to participate in providing accounts, and less interested in personal relationships. Disincentives are suggested, and a theory of 'relationship mindlessness' is discussed, connecting impoverishment of content and incidence with the late emergence of 'personal relationships' as a subject of formal scholarly enquiry in psychology. It is proposed that such mindlessness, and associated disincentives, are implicated in relationship problems, and that extension of relationship education, knowledge and interest are indicated. The practicalities and possible form of learning about relationships and consciousness-raising were explored in a trial relationship understanding course. Counter-indicat ions for such consciousness-raising were evaluated by analogy with music appreciation.

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Gaitonde, Emma Jane Louise. "Candidate genes in schizophrenia". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620185.

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Molefi, Stanley. "Families’ experiences with schizophrenia". Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2567.

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Thesis (MA (Psychology))--University of Stellenbosch, 2009.
ENGLISH ABSTRACT: Families of people with schizophrenia often experience difficult challenges when it comes to dealing with this illness. Contemporary researchers suggest that families often take on the task of caring for their ill relatives with limited resources and support. Mental health professionals often fail to include the families in the treatment of their relatives. Although psychoeducation has been shown to be an important process that helps not only the families but relatives as well, mental health professionals commonly do not involve families in such activities. This study explored the experiences of families of people with schizophrenia and their subsequent contact with mental health professionals, as well as their understanding of schizophrenia as a mental disorder. To this end, a small sample of 10 families (four Xhosa speaking families as well as six Coloured families) was drawn in the Western Cape area on a convenience basis. In each case a family caregiver was interviewed using a semi-structured questionnaire. Data were content analyzed. The findings of the study indicate that families find it difficult to deal with their ill relatives. Families often experience stigma-related incidents because of their relatives. They feel isolated and alone. Families often yearn to receive more information about the illness of their relatives. Also, the contact between mental health professionals and families was reported to be minimal at best. Family members reported that mental health professionals do not include them in the treatment process. Recommendations for further research and practice are made.
AFRIKAANSE OPSOMMING: Die families van mense met skisofrenie kom moeilike uitdagings teë op hul pad met hierdie versteuring. Hedendaagse navorsers vind dat die families gereeld die verantwoordelikheid aanneem om na die siek familielid om te sien met beperkte hulpbronne en ondersteuning. Geestesgesondheidswerkers sluit dikwels nie die families in by die behandeling van hul familielede nie. Alhoewel psigo-opvoeding as 'n belangrike proses erken word, wat nie net die families nie, maar ook die siek familielid help, word dit nie in die praktyk toegepas deur geestesgesondheidwerkers nie. Hierdie studie verken die ervaringe van die families van mense met skisofrenie en hul daaropvolgende kontak met geestesgesondheid werkers, asook hul begrip van skisofrenie as ’n versteuring. Heirvoor is ’n klein steekproef (vier Xhosa-sprekende asook ses Kleurling families) geneem in die Wes-Kaap op ’n gerieflikheidsbasis. In elke geval is ’n semigestruktureerde onderhoud gevoer met ’n familie versorger. Die data is geanaliseer volgens inhoud. Die bevindinge van die studie dui aan dat families dit moeilik vind om hul siek familielede te hanteer. Families ervaar dikwels stigma as gevolg van hul siek familielede. Hulle voel geïsoleerd en alleen. Families smag dikwels daarna om inligting te bekom oor die versteuring van hul familielede. Verder is die kontak tussen families en geestesgesondheidswerkers minimaal ten beste van tye. Families rapporteer dat geestesgesondheid werkers hulle as families nie by die behandelingsproses insluit nie. Voorstelle vir verdure navorsing en die praktyk word gemaak.

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Mar, Corinne Mei. "Selective attention in schizophrenia /". The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487945015617482.

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Sullivan, Courtney R. "Bioenergetic Abnormalities in Schizophrenia". University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1523629996205968.

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Lee, Grace. "Schizophrenia Candidate Genes Study". VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1879.

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Schizophrenia is a debilitating disorder caused by the interaction of genetic and environmental factors. In this study, we identified candidate genes and single nucleotide polymorphisms from two genome-wide association studies, GAIN and CATIE. Nine SNPs representing four candidate genes were selected for replication studies with our Irish samples: Irish Case-Control Study of Schizophrenia (ICCSS), the Irish Study of High-Density Schizophrenia Families (ISHDSF), and the Irish Trio Study of Schizophrenia (ITRIO). In the ITRIO sample, rs4704591 (CMYA5 gene) showed nominal significance (p = 0.0447947). Combining ICCSS, ISHDSF, and ITRIO samples for rs4704591 increased sample size and power and yielded a p-value of 0.00388. This marker remained significant after Bonferroni correction for 9 markers genotyped in this study. CMYA5 gene binds to dysbindin protein in muscle. The dysbindin gene may influence glutamatergic neurotransmission, which has been suspected of being a mechanism by which the pathophysiology of schizophrenia is manifest. Our data suggest CMYA5 gene may be associated with schizophrenia in Caucasian subjects.

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