Teses / dissertações sobre o tema "Samarium – Composés – Synthèse (chimie)"
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Visseaux, Marc. "Chimie organométallique des Lanthanides : synthèse de complexes hétéronucléaires Néodyme ou Samarium-métal d". Dijon, 1992. http://www.theses.fr/1992DIJOS027.
Texto completo da fonteFernández, Gutiérrez Zil. "Dépôt et caractérisation de solutions solides R’1-xRxNiO₃ comme couches sélectives thermorégulées pour le solaire thermique". Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0211.
Texto completo da fonteRare-earth nickelates (RNiO₃) are an intriguing system to study the structural changes correlated to the physical properties. They belong to the perovskite family and exhibit a fascinating and unusual property: the metal-insulator transition (MIT). It allows a change in the material behavior by varying the size of the rare-earth (R) or the temperature. Therefore, they are a promising candidate for solar thermal applications, where a thermochromic absorber layer is crucial for passive thermal regulation. However, nickelates are complex to synthesize, and a simple way to elaborate them would make possible their use on an industrial scale. In this work, we provided for the first time a soft-synthesis route to obtain thermochromic samarium nickelate (SmNiO₃) thin films. The optimization of a two-step procedure based on reactive magnetron sputtering and air-annealing achieve the elaboration of such challenging material in a soft-synthesis way. The detailed structural, electrical, optical, and electronic characterization are presented, showing a reversible behavior with a transition temperature (TMI) between 128 and 138 °C and a transmittance change at 8 µm of up to 32%. Furthermore, the understanding of the mechanisms involved in our synthesis process is also investigated. Mainly, a thermo-kinetic approach to the crystallization progression was developed, as well as the analysis of the Ni³⁺ stabilization with the annealing time. Besides that, the thickness impact on the internal stress state before and after annealing was evidenced. Finally, the MIT control was corroborated through Nd1-xSmxNiO₃ solid solutions, lowering the TMI from 138 to 60 °C for various chemical compositions. The combination of 20 at.% Nd and 80 at.% Sm was characterized in depth, and its crystallization on aluminum substrates was also evaluated
Dittoo, Aurélia. "Synthèse de composés hétérocycliques oxygénés et aminés". Paris 6, 2010. http://www.theses.fr/2010PA066747.
Texto completo da fonteNyffenegger, Coralie. "Synthèse de tricycles énergétiques : nouvelles structures azahétérocycliques condensées". Orléans, 2008. http://www.theses.fr/2008ORLE2033.
Texto completo da fonteFélix, Caroline. "Synthèse et réactivité de composés trifluorométhyles". Lyon 1, 1991. http://www.theses.fr/1991LYO10224.
Texto completo da fonteAnies, Claude. "Synthèse de trans-décalines polyoxygénées : synthèse formelle de la forskoline". Palaiseau, Ecole polytechnique, 1995. http://www.theses.fr/1995EPXX0036.
Texto completo da fonteGarcia, Chantal Arminjon. "Synthèse et réactivité des diylures de diphényldiaminophosphoniums : application à la synthèse d'amines secondaires". Montpellier 2, 1989. http://www.theses.fr/1989MON20150.
Texto completo da fontePetta, Myriam Perrot. "Réactivité des organosilanes pentavalents et applications en synthèse organique". Montpellier 2, 1989. http://www.theses.fr/1989MON20221.
Texto completo da fonteCren-Olivé, Cécile. "Synthèse, physico-chimie et analyse de flavan-3-ols". Lille 1, 2001. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2001/50376-2001-67.pdf.
Texto completo da fonteHenry, Laurence. "Synthèse et activité pharmacologique d'indoloquinolizinones". Montpellier 1, 1997. http://www.theses.fr/1997MON13515.
Texto completo da fonteChèze, Catherine. "Synthèse et réactivité d'azépino et azocino-indoles : une synthèse totale trés courte de la tubotai͏̈wine". Bordeaux 2, 1993. http://www.theses.fr/1993BOR2E001.
Texto completo da fonteGobé, Valérian. "Cyclisations métallo-catalysées pour la synthèse de composés indoliques polycycliques". Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS057/document.
Texto completo da fonteThe indole ring is one of the most prominent heterocycle in natural products or bioactive compounds. The access to complex structures featuring several cycles, stereogenic centers, is one of the main challenge en route to the discovery of new potentially bioactive structures. During this PhD work, we developed metallo-catalyzed cyclizations of tetrahydro-β-carbolines presenting an unsaturated function to access to complex chiral, polycyclic compounds. The asymmetric organocatalyzed Pictet-Spengler reaction was used as a key step for the control of the asymmetry, starting from N-allyl tryptamines and allenaldehydes. The corresponding tetrahydro-β-carbolines were obtained in excellent yields and enantiomeric excesses.Several cyclization reactions were developed using these substrates, catalyzed by Pd(0) or Au(I) complexes, furnishing the targeted chiral tetracyclic derivatives. The mechanisms of these reactions, the regio-, chem- and diastereoselectivity of these reactions was studied. The large numbers of compounds that have been obtained via these routes present a large structural diversity that will hopefully lead to important findings in the field of bioactivity determination
Liu, Zhibo. "Application de la chimie radicalaire par Xanthates: Synthèse des composés hétéroaromatiques". Phd thesis, Ecole Polytechnique X, 2014. http://pastel.archives-ouvertes.fr/pastel-00980912.
Texto completo da fonteHinschberger, Jean. "Nouveaux macrocycles complexants photoluminescents et photoréactifs synthèse-radiocristallographie-photophysique". Bordeaux 1, 1988. http://www.theses.fr/1988BOR10540.
Texto completo da fonteDarcy-Perraud, Anne. "Nouvelles utilisations du diylure de diméthyldiphénylphosphonium en synthèse organique". Montpellier 2, 1991. http://www.theses.fr/1991MON20142.
Texto completo da fonteFayn, Joël. "Synthèse d'hétérocycles f-alkyles par cyclo addition dipolaire-1,3". Nice, 1986. http://www.theses.fr/1986NICE4042.
Texto completo da fonteMaaliki, Carine. "Nouveaux ligands phospho-carbonés : synthèse et chimie de coordination". Toulouse 3, 2012. http://thesesups.ups-tlse.fr/1721/.
Texto completo da fonteThe project developed during this PhD thesis aims at the elaboration of novel ligands with extreme donor character for applications in catalysis. The first part of this work, reports on the synthesis of electron-poor phosphorus ligands especially imidazoliophosphines. The positive charge of the imidazolium moiety of these ligands is conjugated with the phosphorus atom. Thereby, two synthesis methods were developed; while the first consists on the modification of the substituents at the phosphorus atom, the second aims to introduce an additional cationic charge. Both methods have yielded three types of electron-poor ligands, namely the amidiniophosphonites, the di-amidiniophosphines and the cationic hydroxyphosphines. The limits of the coordination of these ligands have been evidenced by the preparation of a series of rhodium (I) complexes. By marked contrast, the second part of this project, concerns the synthesis of electron-rich phosphonium ylide ligands, more particularly the diphosphonium bis-ylides. These ligands were elaborated from the 1,2- or 1,3-diphenylphosphinobenzene bridge, prior to complexation. Preparation of chiral phosphonium ylides were also considered. Finally, the third part of this work focuses on the elaboration of hybrid "rich-poor" ligands having a carbene (NHC) and an amidiniophosphine coordinating extremities. These hybrid bidente ligands were developed for catalytic but also for photo-physic (charge transfer) applications. These new ligands with extreme donating character, electron-poor for the amidiniophosphines, and electron-rich for phosphonium ylides, open interesting perspectives in catalysis
Geffroy, Guillaume. "Synthèse d'analogues de produits naturels par réactions de Diels-Adler hétéroatomiques". Mulhouse, 1987. http://www.theses.fr/1987MULH0060.
Texto completo da fonteBédoui, Ahmed. "Synthèse de spirocylohexylbenzodihydropyranes diversement fonctionnalisès". Paris 11, 1991. http://www.theses.fr/1991PA114834.
Texto completo da fonteVoisin-Chiret, Anne-Sophie. "Synthèse de nouveaux dérivés pyridiniques à visée cholinergique nicotinique". Caen, 2005. http://www.theses.fr/2005CAEN4066.
Texto completo da fonteThe present study describes, on the one hand, the synthesis, the physicochemical study and the biological evaluation of novel pyridylethers as potential nicotinic cholinergic receptor ligands. On the other hand, the Petasis reaction, a multicomponent reaction, is used in the pyridine series to synthesize novel complexes. In the first part, after a general review about nicotinic cholinergic receptors, their localization, their structure and their function as well as a description of different technologies used in parallel chemistry, the chemical study is developed. Various synthetic approaches to prepare pyridylethers were used, along with studies on stability and reactivity. A small but diverse chemical library was accomplished. The first biological results are reported. Further tests are currently under investigation. In the second part, after a general review about multicomponent reactions, the Petasis reaction was studied with an emphasis parallelization. The implementation of this reaction allowed us to obtain original compounds whose structure was investigated and determined as complex (1:1) of dioxaborolanone and an amine. The experimental part of this document describes the procedures and the physicochemical characteristics of the compounds presented. Finally, more than 270 bibliographical references replace this study in its chemical and biological context
Yvorra, Thomas. "Synthèse et étude de composés susceptibles d'activer les cellules MAIT". Thesis, Université Paris sciences et lettres, 2020. https://tel.archives-ouvertes.fr/tel-03200069.
Texto completo da fonteMAIT cells are innate-like T lymphocytes that recognize a series of microbial antigens derived from the riboflavin (vitamin B2) biosynthesis pathway, which are exclusively present in bacteria and some yeasts. The TCR dependent activation of MAIT cells requires an antigenic presentation mediated by MR1 (MHC-class I related protein) expressed mostly by antigen presenting cells (APCs). Once activated, MAIT cells can exert antimicrobial functions notably by killing pathogen-infected cells. This antimicrobial activity suggest a strong therapeutic interest in targeting MAIT cells in innovative antimicrobial immunotherapies. Unfortunately, the most active antigen discovered yet named 5-OP-RU suffers from a high chemical instability, thus making difficult the study of MAIT cell biology. 5-OP-RU is produced from a condensation reaction between its chemical precursor 5-A-RU (also unstable) and endogenous methylglyoxal. To overcome the stability issues, we designed and synthetized stable analogues of MAIT cells trying to maintain a strong potency of MAIT cells activation. We also synthetized prodrugs of 5-A-RU that were able of releasing the molecule in situ to form 5-OP-RU directly in APCs. Finally, we developed a new clickable analogue of 5-OP-RU that can be used to track and visualize MAIT cell antigens in biological tissues and cells by fluorescence microscopy
Turgis, Raphaël. "Synthèse en phase aqueuse : de l’utilisation du poly(éthylène glycol), à la synthèse d’un support de capacité de charge élevée". Paris 11, 2009. http://www.theses.fr/2009PA112141.
Texto completo da fonteAqueous phase organic synthesis is an alternative to the widely developed processes using organic solvents. Although reactions can usually be done under mild conditions increasing yields and selectivity in water compared to the organic solvents, this media remains a marginal solvent in organic synthesis for two main reasons: the poor solubility of the organic compounds, which are often hydrophobic and the difficulty to recover the products at the end of reaction. To overcome these limitations, we have proposed the development of a supported chemistry in aqueous phase using poly(ethylene glycol) (PEG) on which reactive molecules are temporarily fixed. This support has already been used with success for transformations in organic solvents or without solvent but rarely in water. Our approach allows an easy isolation of the product and recycling the support has been validated by our results concerning the Baylis – Hillman reaction. One limitation of the use of PEG as support is his low loading capacity. We have prepared new dendritic PEGs having 6 or 18 fixation sites. Their multistep synthesis has been realized in green solvents (aqueous phase or recyclable solvent). We have illustrated their utilization with the Baylis – Hillman reaction
Blanchard, Stéphanie. "Synthèse d'hétérocycles via les hétarynes : fonctionnalisation et pharmacomodulation des dihydrodipyridopyrazines". Orléans, 2001. http://www.theses.fr/2001ORLE2008.
Texto completo da fonteDagoneau, Christelle. "Chimie des nitrones : application à la synthèse de composés bio-actifs". Université Joseph Fourier (Grenoble), 2001. http://www.theses.fr/2001GRE10102.
Texto completo da fonteOrtega, Esteban. "Synthèse, comportement dynamique et réactivité de nouveaux thiazirconacycles". Dijon, 2003. http://www.theses.fr/2003DIJOS050.
Texto completo da fonteBoisnard, Sabine. "Synthèse asymétrique de l'acide actinoi͏̈dique; vers la synthèse totale de RP66453 : synthèse à haut débit d'aryl triflates et d'aryl nonaflates". Paris 11, 2001. http://www.theses.fr/2001PA112275.
Texto completo da fonteThe complex molecular architecture of Vancomycin and the recent emergence of the vancomycin-resistance phenomenon have rendered it an attractive synthetic target for chemists. In connection with our work aimed at developing a new strategy towards the construction of the ABCOD ring, an efficient synthesis of actinoidic acid common to all the antibiotics belonging to the vancomycin family was required. The first part of this report deals with the synthesis of actinoidic acid, which applies the Meyer's reaction to build the aryl-aryl bond. The other key step is the Strecker reaction based on the use of a sulfinimine as a chiral auxiliary in order to introduce a chiral amino acid. In the second part, we have studied the synthesis of RP66453, a neurotensin antagonist, it could be useful in the treatment of nervous diseases such as Alzheimer's and Parkinson's. Its structure is similar to that of vancomicyne and the main stuctural feature if this natural product is the presence of two macrocycles with an aryl-aryl and an aryl-aryl bond. .
Guinchard, Xavier. "Chimie des nitrones : applications en synthèse organique et à la synthèse de composés bio-actifs". Phd thesis, Grenoble 1, 2006. http://www.theses.fr/2006GRE10104.
Texto completo da fonteThe chemistry of nitrones is a powerful tool for organic chemists to prepare amino or N-hydroxyamino compounds. By virtue of their inherent electrophilic nature, they undergo a range of nucleophilic additions to afford N-hydroxylamines. Reactions of α amino N benzylnitrones with indolic cores gives indolic N-hydroxylamines in good yields. These are key intermediates in the synthesis of indolic alkaloids containing the 1 (indol 3' yl) 1,2 diaminoethane moiety such as discodermindole, topsentins, nortopsentins and hamacanthins. We have developed synthetic strategies to obtain these alkaloids from indolic N-hydroxylamines. However, the difficulty of deprotection of the benzyl group in the presence of other chemical functionalities prone for cleavage under similar conditions, led us to prepare a new class of tert butylcarbamate protected nitrones. These N-Boc protected nitrones undergo a wide range of nucleophilic additions with organometallic reagents affording N-Boc-N-hydroxylamines, whose N-Boc group is easily removed. This method provided a variety of different organic synthons, which we have demonstrated to be powerful in organic synthesis. We engaged them in the synthesis of zileuton, a 5-lipoxygenase inhibitor, and to the synthesis of indolic 1,2-diamines including the 1-(indol-3'-yl)-1,2-diaminoethane moiety, key-intermediate in the syntheses of the targeted alkaloids. We then tried to prepare N-sulfinyl nitrones, whose chiral electron withdrawing protecting group would easily be removed in acidic media and could induce diastereoselectivity during nucleophilic additions. Finally, the results of several biological assays are presented. We evaluated their cytotoxicity, their inhibitory activity on the kinase CK2, the antibiotic activity on Staphylococcus aureus and the inhibitory activity on the efflux pump NorA
Galy, Nicolas. "Synthèse de 13-aryl stéroïdes et études de diverses réactions de synthèse". Aix-Marseille 3, 2010. http://www.theses.fr/2010AIX30053.
Texto completo da fonteOur work is divided in 6 chapters. The first chapter is a bibliographical introduction concerning the biological activity of steroids, their total synthesis, the previous results of the laboratory, the presence of natural steroids with a 17-vinyl group. In the second chapter are shown results concerning the total synthesis of 13-p-bromophenyl-11,11-di(methoxycarbonyl)-3-methoxy-17b-vinylgonatrienes and of derivatives resulting from modifications of their side chain. In the third chapter, we show results about the condensation of ketals of ethylene glycol and catechol with the allylsilane and we show that the diallylation of catechol ketals leads to 4,4-dialkylhepta-1,6-dienes which should later be cyclised in 4,4-dialkylcyclopentenes. Various 1,1-dialkyl-2,5-divinylcyclopentanes are obtained by condensation with the 1,8-bis(trimethylsilyl)octa-2,6 diène (Bislro). Some compounds obtained by condensation of diallylsilanes on anhydrides undergo a metathesis reaction. The results, which constitutes chapter fourth, vary with the catalyst precursor used. The fifth chapter shows the results of ab initio calculalions which were carried out to solve the structure of cationic intermediates of the homoallenic transposition. They are supported by the hydrolysis of deuterated b-allenic tosylates. The sixth chapter is about the synthesis and the reactivity of the C2 molecule
Cénac, Nathalie. "Le zirconium, un outil de synthèse en chimie organique et en hétérochimie". Toulouse 3, 1996. http://www.theses.fr/1996TOU30106.
Texto completo da fonteHénault, Christelle. "Synthèse de récepteurs (poly)cyclo-bis-intercalants dérivés d'acridine". Aix-Marseille 3, 2001. http://www.theses.fr/2001AIX30076.
Texto completo da fonteThe molecular recognition of planar substrates needs the preparation of receptors molecules built on planar bubunits. Heterocyclic dye molecules interact with planar substrates by stacking, or with double stranded nucleic acids by intercalation. In the previous work, our goal was to incorporate two subunits-type into macropolycyclic systems called (poly)cyclo-bis-intercalands. For this purpose, symmetrical diazoted and dioxygenated acridinone and acridine derivatives have been choosed as moieties units. We report here the preparation of several series of these tricyclic planar compounds and their use as monomeric synthons for building artificial (poly)cyclo-bis-intercalands receptors of large size. In the first part of this work, we describe a general synthesis of several members of a novel class of cyclo-bis-intercalands resulting from the double bridging of two acridinone-type subunits. Macrocyclic dimeric structures were readily obtained via the efficient [2-2] condensation between diazoted and dioxygenated derivatives acridinone and various linear polymethylenic and oxopolyethylenic a,w-dichlorides acids
Mwande-Maguene, Gabin. "Conception, synthèse et activité antiplasmodiale de nouveaux composés ferrocéniques". Thesis, Lille 1, 2011. http://www.theses.fr/2011LIL10055/document.
Texto completo da fontePharmacomodulation of biologically active drugs by the introduction of an organometallic entity such as ferrocene constitutes a very interesting alternative to compensate the problematic increase of antimalarial drug resistances. This PhD work is focused on the design, the synthesis and the study of antiplasmodial activity of new ferrocenyl compounds. For this purpose, four families of drugs containing a ferrocenyl entity were synthesized and studied for the first time. Thus, several aminohydroxynaphthoquinones (Atovaquone analog), quinolinyl- and acridinylhydrazones, 4-aminoquinolines (Chloroquine analog) and benzodiazepines (Flurazepam analog) were designed and obtained in good conditions. The ferrocenyl derivatives were evaluated for their antimalarial activity in vitro upon Plasmodium falciparum strains and gabonese clinical isolates. Some of these synthesized compounds have displayed very promising results, in particular for the ferrocenyl 4-aminoquinolines derivatives. The cytotoxic activity and the selectivity index of these compounds have indicated some of them as promising candidates for further development
Salem, Bahaâ. "Cyclocarbopalladation 4-exo-dig : une méthodologie expéditive pour la synthèse de composés polycycliques". Strasbourg 1, 2003. http://www.theses.fr/2003STR13206.
Texto completo da fonteMultistep sequential metallocatalyzed transformations allow considerable increase of molecular complexity, generally associated with new structural changes. In particular, the potential of the palladium catalyzed process has not yet been fully explored. This thesis was focused on the study of an unprecedented domino reaction involving a rare 4-exo-dig cyclocarbopalladation followed by a Stille cross-coupling, for the synthesis of the bicyclic systems including a cyclobutan-1,2-diol. Preliminary encouraging results have been obtained from the tandem reaction of cyclocarbopalladation 5-exo-dig / Stille cross coupling with b-bromopropargylic diols. Then, we have developed the tandem reaction of cyclocarbopalladation 4-exo-dig / Stille cross coupling with a-bromopropargylic diols. A mechanistic study as well as an optimization of the reaction conditions have been undertaken. Depending on the stannylated reagents used, a 6p-disrotatory electrocyclization can occur leading to the formation of a new 6-membered ring. We have also shown that this original methodology can significatively increase the structural complexity of the final products, by extending the tandem reaction to a 8p-conrotatory electrocyclization. This enables us to synthesize polycyclic compounds of the 5-8-5 and 6-4-8-5 type, including a cyclooctatriene, and the structures of which are close to natural biologically active products
Guy, Alexandre. "Synthèse biomimétique de la 15-F2t-IsoP. Synthèse de l'ent 5,6-dihydro-2,3-dinor-15-F2t-IsoP". Montpellier 2, 1998. http://www.theses.fr/1998MON20183.
Texto completo da fonteZill, Nicolas. "Synthèse d’aza-hétérocycles par hydroformylation". Strasbourg, 2011. http://www.theses.fr/2011STRA6202.
Texto completo da fonteIn response to environmental problems due to chemistry, different concepts rised up like atom and step economy and the domino reaction. The objective of this thesis was the development of new synthetic routes towards natural or synthetic products of therapeutic interest respecting at the same time the previous notions. Hydroformylation, one of the most important reactions of homogeneous catalysis, matches the atom economy criterion but it especially allows the realization of chemical constructions initiated by a domino reaction which is a natural way to decrease the number of steps of a reactive pathway. This reaction is a conversion of an olefin into an aldehyde in the presence of a transition metal under a pressure of carbon monoxide and hydrogen. Firstly, hydroformylation allowed the synthesis of oxazolo-pyrrolidine, -piperidine and –azepine patterns by a domino reaction involving amino-alcohols and halogeno-alkenes. These nitrogen bicycles are precious for the preparation of chiral heterocycles after simple chemical transformations onto an aminal function. Another method to prepare in a stereoselective manner these compounds was to use functionalized homoallylamine derivatives using a metallic allylation on oxazolidines followed by a hydroformylation. To prove the efficiency of our strategy, natural products like coniine and solenopsine were synthesized. Finally, hydroformylation of 1,2-disubstituted olefins was under investigation in order to open a route to highly stereoselective C-3 pyrrolidines and piperidines which are excellent drug precursors. The elaboration of functionalized nitrogen heterocycles by domino reaction initiated by hydroformylation seems to be a promising and quick method to synthesize chemical entities of biological interest
Briffaud, Thierry. "Synthèse et caractérisation de polyoxadiazoles-1,3,4". Lyon 1, 1993. http://www.theses.fr/1993LYO10017.
Texto completo da fonteNormand, Mickaël. "Group 13 organometallic chemistry and macromolecular catalytic engineering for polymers issued from bioresources". Rennes 1, 2012. http://www.theses.fr/2012REN1S091.
Texto completo da fonteLe poly(acide lactique) (PLA) est un polymère biocompatible et biodégradable dont les applications sont très diverses et qui est principalement produit par polymérisation par ouverture de cycle (ROP) du lactide (LA). Un grand nombre de catalyseurs/initiateurs particulièrement efficaces ont été synthétisés au cours des trente dernières années, tels que les dérivés alcoxy d'aluminium, de zinc et de métaux des terres rares. Par exemple, les catalyseurs/initiateurs à base d'aluminium furent largement exploités pour la ROP du lactide racémique (rac-LA) pour conduite à de remarquables contrôles des masses moléculaires et des distributions de masses ainsi qu'à un bon contrôle de la stéréochimie du polymère final. Encore aujourd'hui, en raison de voies de synthèses chimiques très spécifiques, les exemples de ROP du lactide impliquant des catalyseurs/initiateurs à base d'indium restent rares. Ainsi, nous reportons dans ce manuscrit de thèse cinq principaux chapitres traitant des sujets suivants : i) synthèse de nouveaux complexes d'indium supportés par des ligands dialcoxy-diimino fluorés de type hémi-salen and leur utilisation en ROP du rac-LA ; ii) préparation de nouveaux complexes {phenoxy-imine} d'aluminium et d'indium et leur propriétés catalytiques en ROP immortelle du lactide ; iii) synthèse de complexes bimétalliques d'aluminum et d'indium supportés par des ligands bis(phenoxy-imine) et leur utilisation en ROP du rac-LA ; iv) processus de réduction de type Meerwein-Pondorf-Verley dans des complexes isopropylate imino-phenolate d'aluminum et d'indium ; v) synthèse de polyesters centrés sur la béta-cyclodextrine par ROP contrôlée d'esters et de carbonate cycliques
Bouda, Hamilton. "Réactions en milieu hétérogène solide-liquide faiblement hydraté : généralisation de la synthèse d'époxydes : synthèse du furyl-2 thiirane et de ses homologues". Toulouse, INPT, 1987. http://www.theses.fr/1987INPT005G.
Texto completo da fonteRabemanatsoa, Amélie Marie. "Synthèse électrochimique d'alcools à partir d'halogènures organiques et de composés carbonyles". Paris 6, 1986. http://www.theses.fr/1986PA066302.
Texto completo da fonteJolivet, Agnès. "Dérivés diacétyléniques du bore, du phosphore et de l'étain en chimie des matériaux : synthèse et comportement thermique". Montpellier 2, 1996. http://www.theses.fr/1996MON20233.
Texto completo da fonteOrtin, Yannick. "Synthèse et réactivité de complexes manganèse-propynylidène dérivés du méthylcymantrène". Toulouse 3, 2002. http://www.theses.fr/2002TOU30036.
Texto completo da fonteArfan, Atef. "Synthèse et réactivité de liquides ioniques en synthèse organique : applications en catalyse et en chimie hétérocyclique". Rennes 1, 2006. http://www.theses.fr/2006REN1S028.
Texto completo da fonteBillet, Manuella. "Préparation d'amines homoallyliques par une réaction à trois composés : application à la synthèse d'hétérocycles azotés". Université Louis Pasteur (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR13074.
Texto completo da fonteBauer, Siegfried. "Généralisation de l'approche phospha-wittig pour la synthèse de phosphaalcenes". Palaiseau, Ecole polytechnique, 1991. http://www.theses.fr/1991EPXX0017.
Texto completo da fonteBeauchard, Anne. "Synthèse de composés hétérocycliques à visée anti-cancéreuse". La Rochelle, 2006. http://www.theses.fr/2006LAROS175.
Texto completo da fonteIn an effort to develope new inhibitors of kinases as anticancer agents, we synthetized original indirubins and azaindirubins substituted in position 5, 5’, 6 and 7. Because of the poor water solubility and low bioavailability, monoxime analogs were also prepared. The effect on cyclin dependant kinase, glycogene synthase kinase-3 and on the survival of human neuroblastoma SH-SY5Y cells were estimated. On the other hand, we synthetized thiazoloindolo[3,2-c]quinolin which are closed to natural alcaloid. We reinvestigated the Graebe-Ullmann condensation under micro-wave. A new scaffold 7H-4,5-diaza-benzo[de]anthracen which is structurally closed to dercitin, a marine alkaloid, was identified. The effect on breast cancers cells, potential DNA intercalating and topoisomerase inhibition were also discussed
Menant, Christine. "Métathèses et cyclisations radicalaires : nouvelle approche pour la synthèse de composés polycycliques azotés d'intérêt biologique". Lyon 1, 2005. http://www.theses.fr/2005LYO10226.
Texto completo da fonteBoughougal, Amina. "Synthèse et caractérisation de composés de coordination antimicrobiens". Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1260.
Texto completo da fonteDevelopment of novel coordination complexes with diverse biological activities (antimicrobial, anti-inflammatory, antifungal, antioxidant and anticancer) is a rapidly evolving field of inorganic chemistry with potential direct impact on quality of life. Metal–drug complexes are of increasing interest in bioinorganic chemistry, leveraging the synergistic effect to lead to compounds with improved pharmacological activity. The recognition of the role of metal ions in biological systems and in treatment of various diseases calls attention to the benefits of studying the interaction of metal ions with organic drug molecules. In continuation with previous works of team, we focus here on the synthesis of new families of metal-antibiotic complexes associating, on one single-molecule, the antiseptic activity of a metal ion with the bioactivity of one or two type of bioactive molecules. Their additive actions have a synergetic effect and lead to more effective and shorter treatments and should strongly minimize the risks for appearance of bacteria mutants. In this work, we succeeded to synthesis the first metal-antibiotic complex associating two types of different antibiotic as ligands with Zn(II). The structure in the solid state of this new complex was established together with the studies of the chemical-physical properties. Comparative studies show it has a better antibacterial activity against (E.Coli, E,Aureus, E.Feacalis ) than parent antibiotics and complexes with only one of the antibiotic. This open a new concept named as Multi-Active Biomolecule Assembly. Moreover, the synthesis and characterisation of new trifluorométhylated antimicrobial ligands are described
Bugaut, Xavier. "Vers la synthèse de l’aglycone des landomycines". Paris 11, 2009. http://www.theses.fr/2009PA112313.
Texto completo da fonteLandomycins are a class of natural products first isolated in 1990 from fermentation of actinobacteria Streptomyces cyanogenus. They consist in a partially aromatic fused tretracyclic aglycone, named landomycinone, and a glycosidic side chain. All members of the family, including the aglycone, exhibited a high antitumoral activity on a large number of cell lines, especially on multidrug resistant ones. We undertook the elaboration of an efficient synthesis of landomycinone. The main synthetic challenge is the construction of partially unsaturated cycle B, wich bears a very fragile alcohol functionality. Three distinct strategies have been studied. The first one relies on the closure of cycle B using an original domino Michael-aldolisation reaction, which has been efficiently performed. However, the construction of the rest of the molecule, notably via a Diels-alder reaction, is for the time not working. Two key-steps were planed within the second retrosynthesis : the construction of secondary alcohol by a Cr (II)-mediated chlorovinylation and then the construction of cycle B by ring-closing metathesis. Low yields and problems of reproducibility led us to give up this strategy. The last approach enabled the construction of the tretacyclic structure of landomycinone by the means of two metal-catalyzed key-steps : an intramolecular alkyne cyclomerisation and a ring-closure metathesis. A final functional transformation (conversion of cycle C into a quinone) is needed to complete the synthesis
Ouizem, Sabrina. "Synthèse de 2,3-méthanopyrrolidines à partir de N-(homoallyl)-α-aminonitriles". Paris 6, 2010. http://www.theses.fr/2010PA066081.
Texto completo da fonteMaurin, Philippe. "Synthèse totale de gonatriènes fonctionnalisés en positions 2,3,11,13 et 17 : Philippe Maurin". Aix-Marseille 3, 2001. http://www.theses.fr/2001AIX30097.
Texto completo da fonteCondensation of 1,8-bis(trimeythylsilyl)octa-2,6-diene with succinic anhydride led to a spirolactone that can be alkylated by diversely substituted iodobenzocyclobutenes. Thermolysis of the resulting product gave 2 or 3, 11, 13 substituted steroi͏̈ds and bearing a 17vinyl group. Those steroids have been submitted to a variety of reactions such as a Wacker-type oxydation of the vinyl group or a Birch reduction of the A ring. We have thus synthetized 50 non-natural steroids bearing a methoxy, hydroxy or a fluoro group in position 2 or 3 ; an ester or a a methoxycarbonyl group at position 11 ; an hydroxyle or a methyle group in position 13, and a carbonyl, vinyl or acetyl group in position 17. The arynes' structure and the key cycloaddition reaction of the aryne on a ketene ketal have been studied on a theorical point of view
Lemaire, Fabrice. "Contribution à la synthèse organique induite par laser : synthèse de composés soufrés : cycloadditions sur les énones". Nice, 1990. http://www.theses.fr/1990NICE4445.
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