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Artigos de revistas sobre o assunto "Respiratory organs Diseases Etiology"
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Lazic, Sava, Tamas Petrovic, Ivan Pusic e Maja Velhner. "Most frequent calf diseases in industrial breeding". Veterinarski glasnik 58, n.º 1-2 (2004): 67–76. http://dx.doi.org/10.2298/vetgl0402067l.
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It is possible to conduct an analysis of the incidence of viral diseases in calves if these diseases are divided into two basic groups. One group comprises diseases of respiratory organs which are manifested by symptoms of a respiratory syndrome, and the second group comprises diseases of digestive tract organs in the form of a gastrointestinal syndrome. It is considered that viruses have the dominant role in the complex etiology of the respiratory syndrome, primarily the IBR virus or the Bovine Herpes Virus-1 (BHV-1), followed by the parainfluenza 3 virus (RSV), the Bovine Viral Diahrrea Virus (BVDV), the bovine Respiratory Syncytial Virus (RSV), but also other viruses, such as adenoviruses, rhinoviruses, coronaviruses, can also influence the appearance of the respiratory syndrome. The respiratory syndrome is rarely caused by a single viral agent, but most frequently by mixed viruses, but also by bacterial infections. Mixed viral infections often have a lethal outcome. Investigations of the etiology of the gastrointestinal syndrome so far indicate that, in addition to bacteria, viruses can also be a significant etiological factor. Rotaviruses, coronaviruses, adenoviruses parvoviruses, herpesviruses (the IBR virus), pestiviruses (BVDV), can be the causes of a gastrointestinal syndrome. It is believed that viruses can be the cause in about 10% cases in the ethiopathogenesis of this syndrome. The paper describes the etiopathogenesis of calf diseases of viral etiology which are most often found in the local conditions of industrial breeding of calves.
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Koteneva, S. V., A. V. Nefedchenko, T. I. Glotova e A. G. Glotov. "Role of bovine respiratory syncytial virus in etiology of respiratory diseases on milk farms". Veterinary Science Today 1, n.º 1 (29 de março de 2021): 38–43. http://dx.doi.org/10.29326/2304-196x-2021-1-36-38-43.
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Bovine respiratory syncytial virus (BRSV) is one of the etiological agents of respiratory diseases. The agent spreads widely in all the countries with intensive livestock farming and can cause pathologic changes in respiratory system either alone or in combination with other viruses and bacteria. It is a matter of crucial importance to study spread of the agent on large milk farms, to detect it in the internal organs of infected animals, and to quantify virus accumulation in them. The purpose of the research was to study peculiarities of RS infection spread, frequency of the virus detection in biomaterial samples (both alone and in associations with infectious bovine rhinotracheitis (IBR) and bovine viral diarrhea/mucosal disease viruses (BVDV) and with Pasteurellaceae bacteria) on large milk farms affected by respiratory animal diseases; and to determine virus concentration in the respiratory organs. BRSV alone was reported in 9.2% of the tested biomaterial samples, as associated with IBR and BVDV it was reported in 1.4% and 5.2% of samples, correspondingly. The number of samples containing simultaneously BRSV and Pasteurellaceae bacteria was 10.8%. The virus was reported in a maximum of 26.6% of the tested samples. With the help of real-time PCR the virus genome was detected in lungs (13.1%), in exudate from trachea, bronchi and nasal sinuses (6.0%), in nasal discharge (4.0%) and in bronchi (1.7%). The virus was seldom detected in trachea and bronchial mucosa (1.1%) and in pulmonary lymph nodes (0.8%). Quantification of BRSV RNA demonstrated that maximum virus accumulation was observed in lungs and nasal charges and it confirms data on its tropism to pulmonary interstitium.
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Stogova, N. A. "Bilateral pleural effusion: etiology, diagnostics". PULMONOLOGIYA 32, n.º 6 (11 de dezembro de 2022): 885–90. http://dx.doi.org/10.18093/0869-0189-2022-32-6-885-890.
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The problem of etiologic diagnosis of bilateral pleural effusions is important because of the relatively large number and variety of diseases accompanied by this syndrome, the complexity of diagnosis verification, and the frequent diagnostic errors. The aim of this review is to describe the spectrum of diseases causing bilateral pleural effusion and to consider a set of diagnostic measures to clarify the etiology of the process. Analysis of 60 literature sources showed that the most common causes of bilateral transudative pleural effusions are cardiac, hepatic, and renal insufficiency. Exudative bilateral pleural effusions are found in inflammatory processes in the pleura, including tuberculosis, and develop when inflammation is transmitted by contact or lymphohematogenous routes from the lungs or other organs. Bilateral localization of pleural effusion in tumor processes is observed in 5.7% of cases. Bilateral pleural effusion is seen in pulmonary embolism, diffuse connective tissue diseases, acute idiopathic pericarditis, postinfarction Dressler syndrome, after pericardotomy, and after pacemaker placement. It may be observed in such rare diseases as sarcoidosis, yellow nail syndrome, and Meigs syndrome, and may be induced by some drugs. Conclusion. The choice of therapeutic measures for bilateral pleural effusion is determined by an accurate etiological diagnosis of the underlying disease. The diagnosis should be based on the patient's clinical data and cytologic, microbiologic, and biochemical analysis of pleural fluid obtained by pleural puncture. In some cases, additional examination methods such as pleural biopsy, bronchoscopy, ultrasound, computed, magnetic resonance imaging of the chest and abdomen, and positron emission tomography are required.
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Garipova, R. V., e Z. M. Berkheeva. "Occupational pathology of respiratory organs in health care workers: issues of timely diagnosis". Russian Journal of Occupational Health and Industrial Ecology, n.º 2 (21 de fevereiro de 2020): 89–92. http://dx.doi.org/10.31089/1026-9428-2020-60-2-89-92.
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Introduction. In the structure of occupational diseases of medical workers, respiratory pathology occupies a leading place, accounting for 60% in the Republic of Tatarstan. The most common are diseases from exposure to infectious agents in the form of various forms of respiratory tuberculosis. Most often, an infiltrative form is diagnosed, accompanied in 48.6% of cases by bacilli discharge.The aim of the study is to explore the structure of occupational respiratory diseases in workers of the healthcare industry of the Republic of Tatarstan, to identify factors that affect their early diagnosis during medical examinations.Materials and methods. A retrospective analysis of cases of occupational respiratory diseases in health care workers according to the office of Rospotrebnadzor of the Republic of Tatarstan and the register of patients of the Republican Center of Occupational Pathology.Results. In the structure of occupational diseases of the respiratory system, the leading place is occupied by pulmonary tuberculosis, amounting to 86%, followed by bronchial asthma–8%, chronic toxic bronchitis–4% and subatrophic rhinopharyngolaryngitis–2%. Analysis of cases of occupational respiratory pathology showed that only tuberculosis was detected during periodic medical examinations. Other respiratory diseases were diagnosed by applying for medical care, when there was a pronounced negative trend and when the disease was initially associated with the profession, we had to talk about sending it to the Bureau of medical and social expertise.Conclusions. Early diagnosis of occupational respiratory diseases of allergic etiology and toxic respiratory lesions in medical workers at periodic medical examinations can be achieved by the quality of a special assessment of working conditions due to the mandatory assessment of the chemical factor-contact with allergens, antitumor drugs, hormones, enzymes of microbial origin, narcotic analgesics, regardless of the concentration of harmful substances in the air of the working area. It is also necessary to take into account the presence of substances with an acute irritant effect.
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Kosenko, I., e E. Ormanzhi. "ANALYSIS OF THE RESULTS OF A SURVEY OF SENIOR STUDENTS OF THE MEDICAL UNIVERSITY ON RATIONAL ANTIBIOTIC THERAPY OF UPPER RESPIRATORY TRACT AND ENT ORGANS INFECTIONS IN CHILDREN". Tavricheskiy Mediko-Biologicheskiy Vestnik 23, n.º 1 (18 de outubro de 2022): 47–53. http://dx.doi.org/10.29039/2070-8092-2020-23-1-47-53.
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Despite the availability of clinical guidelines, the issues of choosing the optimal first-line antibiotic therapy in the treatment of infections of the upper respiratory tract and ENT organs in children still remain relevant. Knowledge of the etiology of infections and the rational apply of systemic antibiotics are formed in senior medical students. Therefore, the purpose of this study is to analyze the knowledge of 6th year students of a medical university on the etiology and antibiotic therapy of upper respiratory tract infections and ENT organs in children, as well as comparing the results with knowledge on these issues of pediatricians. The article presents the results of a survey among the 350 volunteer students of the 6th year of the pediatric faculty on the etiology and antibacterial treatment of upper respiratory tract infections and ENT organs in children. These data have been compaired with the results of the large-scale multicenter study «PATRIOT» (2011-2013) among the pediatricians from 18 cities of Russia. It was revealed that most students overestimate the role of Staphylococcus aureus as the main pathogen in acute otitis media and acute tonsillopharyngitis (tonsillitis) in children. The main group of empirical antibiotic therapy were called aminopenicillins, often inhibitor-protected, whereas the role of natural penicillins in streptococcal tonsillopharyngitis and amoxicillin in acute otitis media and acute sinusitis was underestimated. Among district pediatricians, the frequency of correct answers to questions regarding the etiology and antibiotic therapy of these diseases was significantly higher than among students. It was found that only 9.4% of students and 6.1% of doctors would prescribe antibiotics for uncomplicated acute respiratory infection (ARI), but in real clinical practice they were prescribed in 59.6% of cases. These data indicate a different level of knowledge between students and doctors, as well as the difference in approaches to rational antibiotic therapy in theory and in real practice.
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Korotenko, O. Yu, N. I. Panev, Yu S. Korchagina, R. N. Panev e I. P. Danilov. "Formation of pathology of internal organs in miners with vibration disease". Russian Journal of Occupational Health and Industrial Ecology, n.º 6 (10 de julho de 2020): 399–403. http://dx.doi.org/10.31089/1026-9428-2020-60-6-399-403.
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Introduction. Adverse working conditions can contribute to the development of not only occupational pathology, but also diseases with complex multifactorial etiology, such as hypertension, coronary heart disease, disorders of the musculoskeletal system, chronic non-specifi c respiratory diseases, as well as the formation of combined pathology, which worsens the course of these diseases and leads to the development of complications.The aim of the study is to study the manifestations of somatic pathology in coal industry workers with vibration disease.Materials and methods. We examined 144 coal mine workers with vibration disease caused by local vibration, and 161 control group miners who have been working in contact with local vibration for a long time (15 years or more) and do not have professional pathology.It was found that employees of coal mines with vibration disease more often (70,8%) than workers of the control group (27,3%) (p<0,001), there is a pathology of internal organs: diseases of the cardiovascular system (mainly arterial hypertension), diseases of the digestive system (functional disorders of the biliary tract and non-alcoholic fatt y liver disease), kidney diseases (mainly chronic pyelonephritis), as well as a combination of these diseases. With a more severe course of vibration disease (II degree), pathology of internal organs is more common (81.2%) than in patients with vibration disease of I degree (46.5%) (p<0.001). Conclusions. In miners with vibration disease, more oft en than in the control group, there is a pathology of internal organs: the cardiovascular system, digestive organs, kidneys, as well as a combination of several somatic diseases. In individuals with grade II vibration disease, internal organ pathology is more common than in patients with grade I vibration disease. Th e results obtained should be considered when developing treatment and rehabilitation measures for medical examinations and conducting preventive medical examinations of coal industry workers.
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Volgareva, Alfiya D., E. R. Shaikhlislamova, A. B. Bakirov, E. R. Abdrakhmanova, G. G. Gimranova e L. K. Karimova. "THE ROLE OF INDUSTRIAL AEROSOLS IN THE DEVELOPMENT OF ALLERGIC RESPIRATORY DISEASES AND MEASURES TO REDUCE THEM". Hygiene and sanitation 98, n.º 9 (28 de outubro de 2019): 930–35. http://dx.doi.org/10.18821/0016-9900-2019-98-9-930-935.
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Introduction. Industrial aerosols remain one of the main sources of development of occupational respiratory diseases of allergic etiology, leading to the early and permanent disability of qualified industrial workers. Material and methods. A retrospective analysis of the prevalence of occupational diseases of the respiratory tract from exposure to industrial aerosols according to statistical records and the first time established occupational diseases registration logs in the clinic for the period from 2008 to 2017 was carried out. Results. According to the analysis of occupational respiratory diseases in the Republic of Bashkortostan and the sanitary and hygienic characteristics of working conditions, the development of occupational allergic diseases of the respiratory organs was established in 54% of cases to be associated with exposure to aerosols of complex chemical composition exceeding the maximum permissible concentrations. Discussion. The working conditions of employees in a number of industries are characterized by the predominant effect of industrial aerosols of complex composition influenced the formation of occupational allergic diseases of the respiratory system. Adverse microclimatic conditions at the workplace in combination with a chemical factor are aggravating factors. The largest number of cases of occupational respiratory diseases is registered in the manufacturing sectors of the economy, mining companies, and the construction industry. Conclusion. Based on the studies conducted, measures have been developed to reduce the levels of exposure to industrial aerosols and to maintain workers’ health.
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Churina, E. G., A. V. Sitnikova, O. I. Urazova, S. P. Chumakova, M. V. Vins, A. E. Beresneva e V. V. Novitskii. "Macrophages in bacterial lung diseases: phenotype and functions (review)". Bulletin of Siberian Medicine 18, n.º 1 (16 de maio de 2019): 142–54. http://dx.doi.org/10.20538/1682-0363-2019-1-142-154.
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This literature review is devoted to the analysis of the role of macrophages in the immunopathogenesis of infectious lung diseases of bacterial etiology. The article summarizes information about the origin of macrophages, their phenotypic and functional heterogeneity. The mechanisms of impaired protective function of innate immunity are associated with the polarization of the program of maturation and activation of macrophages in the direction to tolerogenic or immunoregulatory cells with phenotype of M2. Alveolar macrophages perform a variety of functions (from pro-inflammatory to regenerative) in the development of inflammation in the respiratory organs. Their inherent plasticity suggests that the same macrophages can change their phenotype and function depending on the microenvironment in the inflammatory focus at different stages of the disease. Understanding the mechanisms that regulate macrophage plasticity will be an important step towards realizing the potential of personalized immunomodulatory therapy.
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Popova, L. A. "Dynamics of mortality of the Russian population from the main classes of diseases of exogenous etiology". Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences 2 (2021): 39–51. http://dx.doi.org/10.19110/1994-5655-2021-2-39-51.
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The paper investigates the dynamics of mortality of the Russian population from infectious and parasitic diseases, dis-eases of the respiratory and digestive organs. The relevance of the research is determined by a global pandemic, record-ed for the first time after the completion of the first stage of the epidemiological transition in developed countries. The main provisions of the concept of epidemiological transition and the specifics of the transition in Russia are considered. The situation for the thirty-year period 1990–2019, characterized by multidirectional dynamics of life expectancy of the Russian population, for which annual statistics are available, is analyzed in more detail, in order to identify the situation with exogenous mortality in the run-up to the pandemic. Among the six main classes of causes of death, the most significant increase over the period under review was for diseases of the digestive system and infectious and parasitic diseases. In the conditions of the "reverse epidemiological transition", there was a twofold decrease in the ratio of mortality from infectious diseases and diseases of the circulatory system: from 1:51.8 in 1991 to 1:25.6 in 2019. The share of deaths from infections in the structure of deaths from causes increased to 1.8%. Even more significantly, the ratio of deaths from cardiovascular diseases to deaths from diseases of the digestive system decreased by two and a half times: from 1:21.6 in 1990 to 1:8.6 in 2019. The share of these diseases in the structure of mortality increased to 5.5%. Since 2006 diseases of the digestive system occupy the fourth position in the structure of Russian mortality by causes, pushing respiratory diseases to the fifth place. Mortality from respiratory diseases, which trends over the 30 years under review repeat the vector of the total mortality of the Russian population, and which is characterized by the maximum decrease among the maingroups of causes of death, increased the gap with the level of mortality from diseases of the circulatory system from 1:11.1 to 1: 14.2 in 1991–2019. Its share in the structure of mortality decreased to 3.3%.
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Sinitsyn, M. V., M. N. Reshetnikov, B. G. Barskiy, T. I. Abu Arqoub, E. I. Pozdnyakova e D. V. Plotkin. "DIAGNOSTIC SURGERY IN HIVINFECTED PATIENTS WITH DAMAGE OF CHEST ORGANS". HIV Infection and Immunosuppressive Disorders 10, n.º 2 (8 de julho de 2018): 96–102. http://dx.doi.org/10.22328/2077-9828-2018-10-2-96-102.
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The current epidemiological situation in the world, characterized by a constant increase in the number of HIV-infected. The steady progression of HIV infection, even in the presence of antiretroviral therapy (ART), is accompanied by the development of opportunistic diseases. Tubercolosis most often affects patients with HIV infection, as the risk of their illness is 20–37 times higher. Basically, radiation tests and immunological tests are used for the diagnostic of tuberculosis. The main diagnostic criterion for establishing the diagnosis of tuberculosis is detection of the causative agent (Mycobacterium tuberculosis by bacteriological or molecular genetic method. Other diseases with respiratory organs, pleura, and hilar lymph nodes may also occur In patients with HIV infection, which requires differential diagnostic, including surgical methods. It is often necessary to resort to a biopsy of pulmonary tissue, pleura, and hilar lymph nodes to establish a diagnosis. Among surgical methods, the use of minimally invasive operations using endoscopic techniques is most justified. Purpose of the study. Study of safety and effectiveness of the use of surgical methods in the diagnostic of chest diseases in patients with HIV infection. Materials and methods. The results of 105 diagnostic thoracic surgeries in patients with HIV infection which were performed in Moscow Research andClinicalCenterfor Tuberculosis Control of Moscow city Department in period between 2014–2017 were studied. All patients underwent diagnostic surgical interventions. Minimally invasive methods were predominantly used. The obtained diagnostic material was subjected to morphological, molecular-genetic and bacteriological analysis. Results of the research. After surgical interventions in patients with HIV infection with pathological changes in chest organs, unclear etiology, diagnosis of tuberculosis was established in 74 (70,5%) patients, nontuberculous etiology of the disease was detected in 31 (29,5%). Differential diagnosis of chest diseases in patients with HIV infection is an integral part of the work of phthisiatrician, pulmonologist and infectiologist. Surgical interventions in HIV-infected patients do not create a significant risk of changes in the immune status, respectively, their performance is independent of the level of lymphocytes and produced even with severe immunodeficiency. The use of surgical methods in diagnostic of chest diseases is safe, effective and does not lead to a significant number of complications and mortality in patients with HIV infection, regardless of the initial immune status. In addition, in number of patients, the operation is not only diagnostic, but also therapeutic, allowing significantly shortening the duration of treatment, avoiding the appointment of trial therapy. The conclusion. In case of tuberculosis, morphological verification of pathological changes in combination with bacteriological and molecular genetic research of the operation material makes it possible to assign an adequate regime of antituberculous chemotherapy in accordance with the sensitivity of the pathogen. The establishment of non-tuberculous etiology of the identified changes, changes the routing of an HIV-infected patient from an anti-tuberculosis institution to a specialized medical organization of the appropriate profile.
Teses / dissertações sobre o assunto "Respiratory organs Diseases Etiology"
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Reynolds, Paul N. "The role of tachykinins in airway inflammation and bronchial hyper-responsiveness /". Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phr464.pdf.
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Zhao, Hanjun, e 赵旵军. "A study of antiviral peptides with broad activity against respiratory viruses". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/205838.
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A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging viral respiratory diseases such as avian influenza H5N1 and H7N9, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). Previous studies carried out by PhD students in our lab found that mouse β-defenisn 4 (mBD4) shows highly antiviral activity in vitro. However, the recombinant mBD4 (rmBD4) expressed by E.coli is limited to very small scale of production and is very expensive.
Thus, in this study, we firstly screened 16 short peptides derived from mBD4 and other mouse and human β-defensins for identifying their antiviral effects. One short peptide P9 (30 amino acids), derived from mBD4, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses, including influenza A viruses H1N1, H3N2, H5N1, H7N7 and H7N9, SARS coronavirus (SARS-CoV)and MERS coronavirus (MERS-CoV). This P9 showed very high selectivity index (970), which was higher than that of the full-length peptide of synthetic mBD4 (smBD4) and rmBD4 in vitro. Secondly, the prophylactic and therapeutic effects of P9 against the infection of H1N1 virus were further detected in animal model. The survival rate of P9-pretreated mice challenged by lethal dose of H1N1 virus was 100%. The therapeutic effects of P9 protecting mice from lethal challenge of H1N1 virus were also statistically significant. The survival rate of mice could reach up to 67% by intranasal inoculation and 56% by intraperitoneal injection, respectively.
To investigate the antiviral mechanism, we firstly elucidated that P9 could inhibit viral infection but not viral replication or release. Secondly, we detected whether P9 inhibited viral infection by binding to the surface of target cells or viral particles. The results showed that P9 only bound to viral particles but not to the cell surface. It was further identified that P9 bound to viral surface glycoprotein HA but not NA. Thirdly, we demonstrated that P9 did not inhibit virus binding to its receptor and block the virus entry into cells by endocytosis. Instead, P9 inhibited the acidification in late endosomes and thusP9 blocked virus-membrane fusion and subsequent viral disassembly and viral RNA release. Finally, we elucidated that the antiviral activity of P9 was attributed to its high binding affinity to viral HA and the abundance of basic amino acids in its composition.
In this study, we have demonstrated that a short peptide P9, which is derived from mBD4, showed potent antiviral activity against multiple respiratory viruses. This peptide can be developed to a new promising prophylactic and therapeutic agent with broad-spectrum antiviral activity and low possibility to cause drug resistance. Moreover, this study has also revealed a novel antiviral mechanism for P9 and paved a path for the development of new antiviral agents with broad-spectrum antiviral activity against emerging respiratory viruses, such as avian influenza H5N1 and H7N9, as well as SARS-CoV and MERS-CoV.published_or_final_version
Microbiology
Doctoral
Doctor of Philosophy
3
Yip, Ming-shum, e 葉名琛. "Immune responses of human respiratory epithelial cells to respiratory syncytial virus and human metapneumovirus". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3955725X.
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Chaturvedi, Rakesh K. "Reasoning about therapeutic and patient management plans in respiratory medicine by physicians & medical students". Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41562.
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Recently, there has been extensive research in the area of diagnostic expertise. The model of diagnostic reasoning and clinical expertise has been well documented (Patel et al., in press). This study attempts to extend this research in order to include therapeutic reasoning. Using the expert-novice paradigm, this study attempts to investigate the use of knowledge, specifically, both biomedical and clinical sciences, and the directionality of reasoning during decision making about patient management and therapeutic planning in respiratory medicine.Subjects at four levels of expertise were given two clinical problems with the diagnosis and asked (a) to provide therapeutic plans, and (b) describe the underlying pathophysiological explanations of the diseases. Think-aloud protocols were audio-taped and analyzed using methods of protocol analysis. The results showed that the use of basic medical sciences increased as a function of expertise in the procedure-oriented decision-making tasks. The novices generated rule-based prototypical textbook descriptions based on the clinical information, and the diagnosis given in the task. In contrast, the experts' therapeutic responses showed a predominance of causal-level inferences, reflecting more backward-directed inferences than novices. Although both the novices and experts generated forward-directed inferences, the novices were unable to provide accurate and adequate explanations for their decisions. Finally, the pathophysiological explanations of the disease were generated from a different knowledge source than that used to develop therapeutic decisions.
The implications of these findings for development of theory of expertise and for education in the medical domain are discussed.
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Paudyal, Priyamvada. "Respiratory symptoms and lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal". Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=166944.
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Background: Cotton workers are highly exposed to organic dust. Inhalation of cotton based particulate has been associated with various respiratory symptoms and impaired lung function. This study investigates the respiratory health profile of textile mill workers in Nepal in relation to dust and endotoxin exposure. Methods: This study was conducted in four sectors (garment, carpet, weaving and recycling) of the textile industry in Kathmandu, Nepal. A total of 938 individuals completed a health questionnaire and performed spirometry. A subset of 384 workers performed cross-shift spirometry. Personal exposure to inhalable dust and airborne endotoxin was measured during a full-shift for a 114 workers. Results: Geometric mean concentrations of personal exposure to cotton dust and endotoxin were 0.81 mg/m3 and 2160 EU/m3 respectively. Overall prevalence of persistent cough, persistent phlegm, wheeze, breathlessness and chest tightness were 8.5%, 12.5%, 3.2%, 6.5%and 3.6% respectively. Symptoms were most common among the recyclers and less in the garment sector. Exposure to inhalable dust significantly predicted the symptoms of persistent cough and chest tightness. Significant cross-shift reduction in FEV1, FVC, and FEF25_75 were measured in the textile workers (p<0.001 for all); reductions being greater in the recyclers (-143 ml) and smallest in the garment workers (-38 ml) (p=0.012). Cross-shift reduction in FEV1 was significantly predicated by exposure to inhalable dust. Exposure to endotoxin did not correlate with any of the respiratory symptoms nor to lung function. Conclusion: The measured association between exposure to inhalable dust and reporting of respiratory symptoms and lung function suggests that despite high levels of endotoxin exposures, inhalable dust is the driver for these effects and attention should turn to what might be the toxic component in this dust other than endotoxin.
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Wai, Chi-wan, e 衛至韻. "Development of shell vial culture assay for the rapid diagnosis of respiratory viruses using the human colorectal adenocarcinoma (CaCo2) cells". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193551.
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Background: Respiratory diseases are common worldwide, which are caused by various respiratory viruses. As symptoms caused by these viruses are similar, laboratory diagnosis is essential to distinguish the virus. Conventionally, respiratory viruses are isolated by cell culture with a panel of cell lines. However, handling of several cell lines is labour intensive, and the turnaround time of conventional culture is long. In previous study, the use of human colon adeno-carcinoma (Caco-2) in conventional culture was investigated. The study has proven that Caco-2 is generally susceptible to the eight common respiratory viruses, i.e. Adenovirus, Influenza A and B, Respiratory Syncytial virus, Parainfluenza virus 1, 2,3 and 4. As turnaround time of conventional culture is long; therefore, in this study, rapid shell vial culture using Caco-2 cells were evaluated. Moreover, the application of Caco-2 shell vial culture on recovering human metapneumovirus (hMPV) was also investigated.
Materials and methods: This study consisted of four stages. First, recovery of viruses by conventional culture and shell vial culture of Caco-2 were compared. Specimens were added to conventional culture and shell vial simultaneously. For conventional culture, formation of CPE was examined daily and IF staining was performed when CPE was indicated; meanwhile, shell vial culture were incubated for seven days and stained with IF to detect infected cells. In stage two, the effect of incubating shell vial culture in rolling drum was investigated. Shell vials inoculated with the same specimen in duplicate were incubated in rolling drum and without rolling drum simultaneously. IF staining was performed in day 2, and results were obtained. For those which are IF negative in day 2, second shell vial was further incubated to seven days before harvest. In the next stage, a large batch of samples was used to evaluate on the use of Caco-2 shell vial culture in day 2 and day 7. Lastly, Caco-2 shell vial and conventional culture and LLC-MK2 conventional culture were tested for isolation of hMPV.
Results: Compared to Caco-2 conventional culture, recovery rate of shell vial culture was elevated slightly. When experimenting on the effect of incubation in rolling drum, results showed that recovery rate was raised in shell vial with rolling drum in day 2, moreover, the percentage of positive cells were increased significantly (p value < 0.05). Furthermore, in the evaluation of Caco-2 shell vial in day 2 and day 7, 75% of samples were isolated in day 2 while 85% were recovered in day 7. Lastly, in the investigation on recovery of hMPV, 53%, 42% and 17% hMPV positive cases were isolated by Caco-2 shell vial, Caco-2 conventional culture and LLC-MK2 conventional culture respectively.
Conclusion: First, although recovery rate by shell vial and conventional culture were similar, turnaround time was reduced from a week to a few days by shell vial culture. Therefore, Caco-2 shell vial culture is a more efficient than Caco-2 conventional culture in isolating respiratory viruses. The study also showed that incubation of shell vial in rolling drum able to increase the number of positive cells. Furthermore, in this study, Caco-2 cells were also shown to be more efficient in isolating hMPV when compare to LLC-MK2 cells.published_or_final_version
Microbiology
Master
Master of Medical Sciences
7
岑海音 e Hoi-yum Irma Shum. "Interactions of pseudomonas aeruginosa toxins with respiratory mucosa in vitro". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31244725.
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Soh, Kim Lam. "Knowledge about nosocomial pneumonia prevention among critical care nurses in New Zealand a thesis presented in partial fulfillment of the requirement for the degree of Master of Health Science, Auckland University of Technology, September 2003 /". Full thesis. Abstract, 2003. http://puka2.aut.ac.nz/ait/theses/SohK.pdf.
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Thesis (MHSc--Health Science) -- Auckland University of Technology, 2003.Appendix B not included in e-thesis. Also held in print (128 leaves, 30 cm.) in Akoranga Theses Collection. (T 610.7361 SOH)
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Jónsson, Baldvin. "Chronic lung disease of prematurity : a study of selected causative factors and preventive measures /". Stockholm, 1998. http://diss.kib.ki.se/1998/19981204jons/.
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胡慧明 e Huie-ming Hou. "Long-term study of sleep apnoea patients treated with MAD". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45012222.
Texto completo da fonteLivros sobre o assunto "Respiratory organs Diseases Etiology"
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Albert, Hirsch, ed. Prevention of respiratory diseases. New York: M. Dekker, 1993.
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L, Johnston Sebastian, e Papadopoulos Nikolaos G, eds. Respiratory infections in allergy and asthma. New York: Marcel Dekker, Inc., 2003.
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1943-, Stein Mark R., ed. Gastroesophageal reflux disease and airway disease. New York: Marcel Dekker, 1999.
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George, Thomassen David, e Nettesheim Paul, eds. Biology, toxicology, and carcinogenesis of respiratory epithelium. New York: Hemisphere Pub. Corp., 1990.
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Romain, Pauwels, Postma D. S e Weiss Scott T, eds. Long-term intervention in chronic obstructive pulmonary disease. 2a ed. New York: Marcel Dekker, 2005.
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Holt, Paul F. Inhaled dust and disease. Chichester: Wiley, 1987.
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Difficult airway management. Oxford: Oxford University Press, 2009.
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Johnson, N. Mcl. Respiratory medicine. 2a ed. Oxford: Blackwell Scientific Publicatrions, 1990.
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Rush, Bonnie. Equine respiratory diseases. Oxford, UK: Blackwell Science, 2004.
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Respiratory medicine. Oxford: Blackwell Scientific, 1986.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Respiratory organs Diseases Etiology"
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Marchuk, Guri I. "Viral And Bacterial Infections of Respiratory Organs". In Mathematical Modelling of Immune Response in Infectious Diseases, 269–89. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-015-8798-3_9.
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TIDY, NOËL M. "DISEASES OF THE RESPIRATORY ORGANS". In Massage and Remedial Exercises, 342–72. Elsevier, 2013. http://dx.doi.org/10.1016/b978-1-4831-9740-1.50026-6.
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"Miscellaneous Diseases of Uncertain Etiology". In Non-Neoplastic Disorders of the Lower Respiratory Tract, 857–900. American Registry of Pathology and the Armed Forces Institute of PathologyWashington, DC, 2002. http://dx.doi.org/10.55418/1881041794-17.
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Sriram, Anitha, Balram Prajapati, Srushti Mahajan, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava e Pankaj Kumar Singh. "Etiology of COVID-19". In An Update on SARS-CoV-2: Damage-response Framework, Potential Therapeutic Avenues and the Impact of Nanotechnology on COVID-19 Therapy Volume 1, 91–112. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815039863122010008.
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Etiology means the causation of a disease, where one or more factors are combined to cause the illness. In the case of COVID-19, etiological studies are helpful to determine the factors causing illness and they are required to pave the way for advanced treatment options. The main etiology for COVID-19 is immunopathogenesis which can be explained in terms of different stages of infection. This book chapter summarizes the etiology of COVID-19, different stages of COVID-19 infection, and the innate and adaptive immune response of the host to 2019-nCoV. In the early stages of infection, mild viral infection targets the nasal epithelial cells, followed by bronchial epithelial cells, and alveolar pneumocytes. In the moderate type of infection, Type-II pneumocytes are induced by the associated viral pyroptosis that leads to the triggering of IL-1β inflammatory signals, which is regarded as a localized inflammatory response. In the severe type of infection, exuberant cytokine storm syndrome (CSS) causes inflammation of the lungs, enhanced vascular hyper-permeability, and diffuse alveolar damage (DAD). As a result of the above effects, the severe stage of infection is characterized by pneumonia, ARDS (acute respiratory distress syndrome), and ALI. The infection causes CSS hyper-inflammation which additionally causes SIRS (Systemic inflammatory response syndrome). This SIRS finally leads to septic shock and multiple organ damage. Organ dysfunction for the liver, heart, and kidney is another problem for patients.
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Krishnamurti, Chandrasekhar. "Historical Aspects of Hyperbaric Physiology and Medicine". In Respiratory Physiology. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.85216.
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The history of hyperbaric oxygen therapy (HBOT) makes for fascinating reading. From pneumatic chambers and compressed air baths to empirical therapeutic applications during the nineteenth century, the impetus to scientific application of HBOT began in seeking solution for decompression sickness during various construction ventures. French physiologist Paul Bert’s research was pathbreaking and provided a scientific explanation on the etiology of the “bends.” In 1908, JS Haldane’s experiments recommended staged decompression and made diving safe. In 1921, OJ Cunningham employed HBOT to treat hypoxia secondary to lung infections successfully. It was cardiac surgeon Ite Boerema who put HBOT on a solid footing with his open-heart surgery results in various pediatric cardiac conditions and rightly deserved the title of father of modern-day hyperbaric medicine. From 1937 onwards, HBOT research snowballed into treating a wide variety of diseases. In 1999, the Undersea and Hyperbaric Medical Society and Food and Drug Administration recognized the value of HBOT, and this led to its becoming a major tool in the armamentarium of clinicians, either as a primary or adjunctive therapy for a spectrum of diseases.
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Gibson, G. J. "Respiratory function tests". In Oxford Textbook of Medicine, editado por Pallav L. Shah, 3956–70. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0399.
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Respiratory function tests are used in diagnosis, assessment, and prognosis and in monitoring the effects of treatment of various respiratory conditions. In the diagnosis of specific diseases, respiratory function tests—like functional tests of other organs—inevitably have limitations. Their use as a diagnostic tool is in recognizing patterns of abnormality which characterize particular types of disease; more often they are used to quantify the severity of functional disturbance or to locate the likely anatomical site(s) of disease (airways, alveoli, or chest wall). The commonly applied tests are most conveniently classified as (1) tests of respiratory mechanics, (2) carbon monoxide uptake, (3) arterial blood gases and acid–base balance, and (4) exercise.
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Wolff, Julia G. B., Wellington P. dos Santos e Pedro Bertemes-Filho. "Absolute Images Reconstruction in Heart and Lungs for COVID-19 Patients using Multifrequencial Electrical Impedance Tomography System and D-Bar Method". In Intelligent Diagnosis of Lung Cancer and Respiratory Diseases, 130–225. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815050509122010010.
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Brazil is one of the countries most affected by the COVID-19 pandemic. Since the beginning of November 2020, Brazil has been experiencing an acute crisis of the disease, with an increase in cases, hospitalizations and deaths, including among the youngest. During the month of April 2021, as intensive care units they were working almost at full capacity throughout the country. Since the beginning of the pandemic, in March 2020, without total, Brazil has reported more than 14 million cases of COVID- 19 and more than 400 thousand deaths. Due to the rapid spread of the virus and due to the fact that the health systems of different countries are not prepared to serve the large number of patients affected by this disease, we have proposed the use of multifrequency electrical impedance tomography (MfEIT) in the management of pulmonary disease in ICU beds. There are several other forms of tomographic imaging that deliver better image resolution, however, MfEIT has some advantages over CT Scan and X-rays, which are: the absence of ionizing radiation, the portability of the equipment, the possibility of access remote control of the patient's clinical data by the medical team, the visualization of dynamic pulmonary and cardiac parameters that are not seen in computed tomography images, nor in ultrasound images. However, an application of the D-Bar algorithms developed by Siltanen and his team, from 2012 to 2020, at the University of Helsinki, Finland, for viewing images in patients with COVID-19 was evaluated. Various scenarios and criteria were proposed in the text and the results obtained promising evidence for imaging internal organs in the radio frequency range. As expected, codes cannot be considered in extremely low frequency situations, as reconstructions are not considered. In the future, we seek to work with deep neural networks to speed up the simulation of images and to compare results.
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Cui, Wanting, Manuel Cabrera e Joseph Finkelstein. "Latent COVID-19 Clusters in Patients with Chronic Respiratory Conditions". In Studies in Health Technology and Informatics. IOS Press, 2020. http://dx.doi.org/10.3233/shti200689.
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The goal of this paper was to apply unsupervised machine learning techniques towards the discovery of latent COVID-19 clusters in patients with chronic lower respiratory diseases (CLRD). Patients who underwent testing for SARS-CoV-2 were identified from electronic medical records. The analytical dataset comprised 2,328 CLRD patients of whom 1,029 were tested COVID-19 positive. We used the factor analysis for mixed data method for preprocessing. It performed principle component analysis on numeric values and multiple correspondence analysis on categorical values which helped convert categorical data into numeric. Cluster analysis was an effective means to both distinguish subgroups of CLRD patients with COVID-19 as well as identify patient clusters which were adversely affected by the infection. Age, comorbidity index and race were important factors for cluster separations. Furthermore, diseases of the circulatory system, the nervous system and sense organs, digestive system, genitourinary system, metabolic diseases and immunity disorders were also important criteria in the resulting cluster analyses.
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Amin, Mohamed M. "Neurodegenerative Disorders". In Advances in Medical Diagnosis, Treatment, and Care, 195–216. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-5282-6.ch009.
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Neurodegenerative diseases (NDs) are characterized by specific dysfunction and damage of neurons related to pathologically changed proteins that deposit in the patient brain but also in peripheral organs. These proteins can be used for therapy or used as biomarkers. Except for a plethora of alterations revealed for dissimilar neurodegeneration-related proteins, amyloid-β, prion protein, TAR DNA-binding protein 43 (TDP-43, transactive response DNA binding protein 43 kDa), tau and α-synuclein, or fused in sarcoma protein (FUS), molecular classification of NDs depend on the full morphological assessment of protein deposits, their spreading in the brain, and their correspondence to clinical signs with specific genetic modifications. The current chapter represents the etiology of neurodegeneration, classification of NDs, concentrating on the maximum applicable biochemical and anatomical characteristics and most imperative NDs.
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Naser Moghadasi, Abdorreza. "Psychological Aspects of Neuroinflammatory Disorders in COVID-19 Era". In Anxiety, Uncertainty, and Resilience During the Pandemic Period - Anthropological and Psychological Perspectives [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97629.
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Although the COVID-19 pandemic was initially manifested as a contagious respiratory infection, its other aspects quickly became apparent. Accordingly, the disease could affect various organs such as skin, digestive system, and the central nervous system. Apart from these diverse manifestations, it was rapidly cleared that the virus could potentially play a role in causing a wide range of autoimmune diseases. Moreover, various anthropological aspects of COVID-19 and its effects on human life were considered. In this regard, one of the important issues is its psychological effects, not only on the population of healthy people, but also on people suffering from underlying diseases. Inflammatory diseases of the central nervous system are included as one group of these diseases. Since these diseases can cause many psychological problems in patients, it is very important to pay attention to them during the COVID-19 pandemic. In the following section, the psychological aspects of COVID-19 in patients with neuroinflammatory diseases are described.
Trabalhos de conferências sobre o assunto "Respiratory organs Diseases Etiology"
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Guarino, Maria, Marlene Lages, Ipek Suluova, Rui Fonseca Pinto e Nuno Lopes. "The CBmeter: designing innovative strategies for early diagnosis of metabolic diseases". In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1001410.
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Diabetes is a disease with high prevalence worldwide, however, about 44% of patients are asymptomatic, which leads to a later diagnosis of the disease and, consequently, increases the risk of developing complications. The development of new approaches for early diagnosis is imperative to allow proper adoption of preventive measures. From a motivational point of view, it is easier for patients to adopt healthy eating habits and lifestyles when there is an altered marker that indicates subclinical disease, particularly in a pathology that remains asymptomatic until advanced stages. Thus, timely diagnosis based on a measurable and monitorable indicator is extremely important so that such behaviors are implemented as early as possible, increasing effective health gains and reducing the costs related to this pathology. Pre-clinical studies in animal models have shown that the etiology of type 2 diabetes mellitus (T2DM) is related to alterations in the carotid bodies (CB), chemosensory organs located in the bifurcation of the carotid arteries. In animals with T2DM it has been observed that the CBs are overactivated causing an increased heart rate, respiratory rate, and blood glucose levels. In humans, this mechanism has been confirmed but is not yet well-characterized. This paper highlights the importance of developing a device that allows early detection of changes in CB activity correlating it with emerging diabetes. The design strategies to prototype the CBmeter were to model and characterize the features of interest for the diagnosis- respiratory rate, heart rate, peripheral oxygen saturation and glucose - in healthy people and people with diabetes using a combination of set commercial sensors pre-existent in the market that were integrated to collect real-time data. After determining health and disease patterns, the CBmeter development pipeline includes a co-design approach in which physiologists, endocrinologists, nurses, computer and electrical engineers, designers and patients are collaborating to develop an easy-to-use, portable, and minimally invasive medical device that associates CB function with endocrine dysregulation, with very small discomfort and risk for users. The definition and specification of the most appropriate architecture for the CBmeter, in order to allow its modularity, signal acquisition and consequently the communication between the sensor/device and the receiver/backend in the most efficient way is being allied to the selection of materials, tools and steps to create an innovative product, that will fill a technical gap in the market, designed for the early diagnosis of metabolic diseases, in a subclinical phase, with the potential to contribute with significant gains for public health in the medium/long term.
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Evseeva, G., E. Knizhnikova, R. Telepneva, N. Kuderova, S. V. Suprun, E. Suprun, V. Kozlov e O. Lebed'ko. "Mitochondrial Dysfunction in Chronic Diseases of the Respiratory Organs". In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3453.
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Крумкачева А.Ю., Крумкачева А. Ю. "State of respiratory system and peripheral musculature in patients with dust diseases of respiratory organs". In The second international youth Forum "OCCUPATION AND HEALTH". PT "ARIAL", 2018. http://dx.doi.org/10.31089/978-5-907032-51-4-2018-1-141-148.
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Grigoreva, I., E. Volkova e I. Belikova. "IMPACT OF CARDIO TRAINING ON THE BODY". In Current issues and prospects for the development of modern science. FSBE Institution of Higher Education Voronezh State University of Forestry and Technologies named after G.F. Morozov, 2022. http://dx.doi.org/10.34220/cipdms2022_94-99.
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The article discusses the effectiveness and variety of cardio training and their benefits. Lack of physical activity in our lives can lead to a whole range of diseases. Cardio loads can strengthen our body and improve well-being. When using cardio loads, the activity of the circulatory system, heart, respiratory organs improves, endurance increases.
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Taebi, Amirtahà, e Fardin Khalili. "Advances in Noninvasive Diagnosis Based on Body Sounds and Vibrations – A Review". In ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-73815.
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Abstract This paper provides a brief overview of the advances in the area of early identification of different types of abnormalities and diseases, including respiratory illnesses and cardiovascular diseases, using noninvasive screening of biomedical acoustic signals. These signals include sounds and vibrations generated by different human body organs and systems that can be measured on the body surface using sensors such as stethoscopes and accelerometers. In this study, the measurement methods and signal processing algorithms for customized feature extraction and classification as well as clinical potentials, current limitations, and future directions are briefly reviewed and discussed.
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Aralovets, N. "Morbidity of Children in the RSFSR in the 1970s–1980s". In XIII Ural Demographic Forum. Global challenges to demographic development. Institute of Economics of the Ural Branch of RAS, 2022. http://dx.doi.org/10.17059/udf-2022-1-1.
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The paper examines the features and patterns of morbidity of children in the RSFSR in the 1970s-1980s. Using mainly archival sources, as well as statistical, demographic and historical methods, the study showed that the indicators of the health status of children were generally good in the 1970s and 1980s in the RSFSR. However, in the structure of morbidity of children, along with traditional diseases of the respiratory and digestive organs, infectious and parasitic diseases, new diseases of the circulatory system, cancer (including malignant) neoplasms, as well as accidents, poisoning and injuries, were noted. The appearance of new diseases in the RSFSR, previously unusual for children, confirmed the development of epidemiological transition. Since this phenomenon has not been sufficiently investigated in Russian and foreign historiography, the paper presents new scientific data.
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Bazarova, E. L., I. S. Osherov e N. A. Roslaya. "THE FEATURES OF FORMATION SOMATIC PATHOLOGIES AT INFLUENCE OF LOCAL VIBRATION IN THE CONDITIONS OF METALLURGICAL MANUFACTURE". In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-48-53.
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Abstract: Relevance. Local vibration is a significant factor in the production environment of metallurgical production, which affects health and efficiency. The aim of the study is to identify the exposure, gender and age features of the formation of general somatic morbidity associated with the impact of local vibration in the production of titanium alloys. Scope and methods. The prevalence of general somatic pathology was compared in 2596 workers who have contact with local vibration, with varying degrees of harmfulness of working conditions, and non-exposed persons according to the results of periodic medical examination using the methodology of occupational risk analysis of the Research Institute of Occupational Medicine. academician N. F. Izmerov. Results. At comparison of prevalence of a somatic pathology at workers in contact to local vibration to not exhibited persons according to medical inspection, and at different degree of harm of working conditions, are revealed the raised risks of formation of diseases nervous, kostno-muscular, endocrine systems, respiratory organs, digestion, an ear, a skin, an arterial hypertensia, the mental frustration, the raised weight of a body, gynecologic diseases with a tendency of growth of the majority of them at the big levels of vibration, more often at small, less often - average degree of communication with working conditions. The frequency of pathology in exposed workers was higher in all age groups. Average degree of communication with working conditions of a gynecologic pathology at the age of 18-25 years was marked. At men frequency of a pathology of respiratory organs, digestion is revealed authentically big, than at women; an ear; skin at the big relative risks 1,2-1,3, of the raised arterial pressure and hyperglycemia. Conclusion. A higher frequency of visceral pathology of a number of body systems under the influence of local vibration of high levels may justify the need to develop differentiated preventive programs to minimize its negative impact, taking into account the identified features in sex and age groups.
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Churanova, А. N. "MORBIDITY WITH TEMPORARY DISABILITY IN TWO INDUSTRIAL REGIONS OF RUSSIA". In The 4th «OCCUPATION and HEALTH» International Youth Forum (OHIYF-2022). FSBSI «IRIOH», 2022. http://dx.doi.org/10.31089/978-5-6042929-6-9-2022-1-199-203.
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Introduction: The study of morbidity with temporary disability (MTD) in industrial regions is an urgent task, since the loss of working time due to workers diseases adversely affects the volume of production and output, and accordingly, the welfare of entire subject population. The goal: To analyze the morbidity with temporary disability indicators in two industrial regions of Russia. Methods: The analysis of men and women MTD cases frequency in two industrial regions (Kemerovo and Chelyabinsk regions) and in all Russia for 2014-2018 to form 16-TD and to Rosstat data on the number of people employed in Russian economy. Also, in the studied territories, the 5-year averaged indicators for the leading classes of diseases, depending on gender, were calculated. Results: The performed analysis of quality management system for 2014-2018 period testified the worst health indicators among workers in Kemerovo and Chelyabinsk regions compared to Russia. In certain years, the frequency of cases of MTD in men in industrial regions was almost 30% higher than in the country. Higher MTD levels in the regions were also recorded from certain classes of diseases (diseases of circulatory system, musculoskeletal system and respiratory organs). Conclusion: The information about health indicators in the regions can be used in the development of medical and preventive programs of workers health preservation.