Artigos de revistas: "Regulation no 883"

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Pennings, Frans. "Conclusion: Simplification, Modernisation and Regulation 883/2004". European Journal of Social Security 11, n.º 1-2 (março de 2009): 235–41. http://dx.doi.org/10.1177/138826270901100112.

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Golynker, Oxana. "Guest Editor’s overview of the Special Issue". European Journal of Social Security 22, n.º 2 (junho de 2020): 103–9. http://dx.doi.org/10.1177/1388262720936375.

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The aim of this Special Issue is to present a critical analysis of the reform of the coordination of social security in the light of the 2016-2019 revision of the EU Regulations on the coordination of social security. The articles scrutinise all areas of the Commission’s proposal for amending Regulation (EC) No 883/2004 on the coordination of social security systems and Regulation (EC) No 987/2009, which lays down the procedure for implementing Regulation (EC) No 883/2004. The introduction provides an overview of the negotiation of the Commission’s proposal and outlines the aims and the structure of the Special Issue.

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Pennings, Frans. "Introduction: Regulation 883/2004 – The Third Coordination Regulation in a Row". European Journal of Social Security 11, n.º 1-2 (março de 2009): 3–7. http://dx.doi.org/10.1177/138826270901100101.

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Jorens, Yves, e Filip van Overmeiren. "General Principles of Coordination in Regulation 883/2004". European Journal of Social Security 11, n.º 1-2 (março de 2009): 47–79. http://dx.doi.org/10.1177/138826270901100103.

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Pennings, Frans. "Coordination of Unemployment Benefits under Regulation 883/2004". European Journal of Social Security 11, n.º 1-2 (março de 2009): 177–203. http://dx.doi.org/10.1177/138826270901100109.

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García de Cortázar Nebreda, Carlos. "PRINCIPIO DE ASIMILACION EN EL REGLAMENTO 883/04". E-REVISTA INTERNACIONAL DE LA PROTECCION SOCIAL 3, n.º 1 (2018): 3–18. http://dx.doi.org/10.12795/e-rips.2018.i02.02.

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Verschueren, Herwig. "Regulation 883/2004 and Invalidity and Old-Age Pensions". European Journal of Social Security 11, n.º 1-2 (março de 2009): 143–62. http://dx.doi.org/10.1177/138826270901100107.

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Devetzi, Stamatia. "The Coordination of Family Benefits by Regulation 883/2004". European Journal of Social Security 11, n.º 1-2 (março de 2009): 205–16. http://dx.doi.org/10.1177/138826270901100110.

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Vonk, Gijsbert. "The EU (non) co-ordination of minimum subsistence benefits: What went wrong and what ways forward?" European Journal of Social Security 22, n.º 2 (29 de maio de 2020): 138–47. http://dx.doi.org/10.1177/1388262720928772.

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This contribution deals with the co-ordination of minimum subsistence benefits in EU law. It is argued that the distinction between social assistance schemes and non-contributory benefits in EU social security law is becoming increasingly redundant. This is recognised in the case law of the CJEU, although paradoxically not in a way that strengthens the rights of mobile citizens, but in an adverse manner that undermines the co-ordination efforts of non-contributory benefits under Regulation 883/2004. In order to overcome this problem, it is argued that social assistance should be included in the material scope of application of Regulation 883/2004. This regulation should abandon the concept of special non-contributory benefits and introduce a new category of minimum subsistence benefits, which would also include social assistance schemes. Such a change could be accompanied by a single, coherent principle to govern the relationship between the right to benefits (Regulation 883/2004) and residence rights (Directive 2004/38), if necessary supported by a cost sharing mechanism for minimum substance benefits under Regulation 883/2004 and, preferably, by a recognition of minimum protection standards for economically non-active EU citizens without a legal right of residence.

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Schoukens, Paul, e Danny Pieters. "The Rules within Regulation 883/2004 for Determining the Applicable Legislation". European Journal of Social Security 11, n.º 1-2 (março de 2009): 81–117. http://dx.doi.org/10.1177/138826270901100104.

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Cornelissen, Rob. "The New EU Coordination System for Workers Who Become Unemployed". European Journal of Social Security 9, n.º 3 (setembro de 2007): 187–219. http://dx.doi.org/10.1177/138826270700900301.

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The aim of this article is to discuss the chapter on unemployment benefits in Regulation (EC) 883/04 of the European Parliament and of the Council of 29 April 2004 on the coordination of social security schemes. This regulation is part of the ongoing simplification and modernisation of the coordination of Member States' social security schemes and will probably become applicable in 2009. The article illustrates the principal differences between the unemployment chapter of this new regulation and the existing provisions in Regulation 1408/71, and explains some of the difficulties encountered in the attempt to modernise and simplify these rules. It also shows why the extensive case-law of the Court on the provisions in the unemployment chapter of Regulation 1408/71 continues to be useful in the interpretation of the unemployment chapter of the new Regulation 883/04, since this chapter is, to a large extent, based on the provisions of the first Regulation.

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Hahn, Erik. "Basic Principles of European Social Security Coordination based on Regulation (EC) 883/2004". SOCRATES. Rīgas Stradiņa universitātes Juridiskās fakultātes elektroniskais juridisko zinātnisko rakstu žurnāls / SOCRATES. Rīga Stradiņš University Faculty of Law Electronic Scientific Journal of Law 2, n.º 26 (outubro de 2023): 35–42. http://dx.doi.org/10.25143/socr.26.2023.2.35-42.

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This article discusses the importance of free movement and the coordinating social law of the European Union (EU) inensuring that people who move between EU Member States are not left without social security coverage. The articleexplains that the EU does not have a uniform or common social law and that the responsibility for social policy primar-ily lies with the Member States. The coordinating social law of the EU is limited to the coordination of the various socialsecurity systems of the Member States. The article further explains that the coordination of social security systems isessential for the success of European integration and emphasises that the EU Member States are bound by both thebasic Regulation (EC) No 883/2004 and the implementing Regulation (EC) No 987/2009. After a primary law derivationof the social law coordination, the article explains the scope of application and the key principles of Regulation (EC)883/2004. This is followed by a discussion of the Regulation’s conflict-of-law rules, which take precedence over nationalprovisions.

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Grigoryev, Viсtor, Alexander Sukhodolov, Sergey Ovanesyan, Marina Spasennikova e Vladislav Tyunkov. "Digital Information Platforms as an Object of Normative Legal Regulation in the Sphere of Criminal Proceedings". Russian Journal of Criminology 13, n.º 6 (26 de dezembro de 2019): 873–83. http://dx.doi.org/10.17150/2500-4255.2019.13(6).873-883.

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While noting the general trend for the regulation of digital relations in the sphere of criminal court proceedings, the authors draw attention to the absence of a common approach to this work, or of a universal understanding of criminal procedure norms regarding digital relations, as well as to the drawbacks in preparing new norms that regulate digital relations. Problems connected with the regulation of electronic processes are not specific for Russia only. Laws of some countries do not recognize evidence obtained electronically, and view it as secondary. The results of implementing the road map of digital economy and the approaches to the definition and typification of digital platforms are the basis for laying the foundations of the criminal proceedings’ digitization in Russia. Large-scale growth of innovations for the platforms and an increasing complexity of their architecture enable the solution of a new research task — the spread of digital platforms to various sectors, in this case, to the sphere of criminal proceedings. The authors use the definition of a digital platform approved by the Russian Governmental Commission on Digital Development to formulate their own definition of a digital information platform as an object of normative legal regulation in the sphere of criminal proceedings and prove that it should belong to sectoral digital platforms. The value of the transition to the normative legal regulation of digital information systems in the sphere of court proceedings lies in the reduction of costs and the elimination of the subjective factor by using a package of digital technologies of data processing and changing the system of the division of labor while reaching the purpose of criminal justice. The authors also stress the inappropriateness of simplification and primitivism, when a criminal procedure system is mechanically viewed as a system of distributed registers (blockchain), or when digitization is used as an excuse for suggesting the abolishment of investigative departments as parasites in the digital reality where crime investigation and solution become a job for ordinary internet users.

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García de Cortázar Nebreda, Carlos. "ACCIDENTES DE TRABAJO Y ENFERMEDADES PROFESIONALES EN EL REGLAMENTO 883/04. UN EJEMPLO DE COORDINACIÓN MÍNIMA." E-REVISTA INTERNACIONAL DE LA PROTECCION SOCIAL 1, n.º 6 (2021): 13–51. http://dx.doi.org/10.12795/e-rips.2021.i01.02.

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El autor examina la regulación del capítulo de Accidentes de Trabajo y Enfermedades Profesionales contenida en el Reglamento 883/04. Incide en los aspectos más importantes de la coordinación de las prestaciones de estas ramas de seguro. Hace hincapié, fundamentalmente, en la problemática de los trabajadores desplazados que sufren un accidente de trabajo o contraen una enfermedad profesional en un Estado distinto del Estado de aseguramiento (Estado competente). Analiza el principio de asimilación de hechos y acontecimientos, contemplada en el artículo 5 del Reglamento 883/04, en relación con los accidentes de trabajo. Pone en duda la jurisprudencia española al respecto y cuestiona los argumentos jurídicos esgrimidos por el Tribunal Supremo. Ofrece una panorámica general de la jurisprudencia del Tribunal de Justicia sobre accidentes de trabajo y enfermedades profesionales, así como sobre el principio de asimilación de hechos y acontecimientos.

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Guindo Morales, Sara. "LAS PRESTACIONES POR DESEMPLEO EN LA PROPUESTA DE REGLAMENTO POR EL QUE SE MODIFICAN LOS REGLAMENTOS (CE) NÚM. 883/2004 Y NÚM. 987/2009". E-REVISTA INTERNACIONAL DE LA PROTECCION SOCIAL 3, n.º 1 (2018): 19–44. http://dx.doi.org/10.12795/e-rips.2018.i02.03.

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Verschueren, Herwig. "Free Movement or Benefit Tourism: The Unreasonable Burden of Brey". European Journal of Migration and Law 16, n.º 2 (23 de maio de 2014): 147–79. http://dx.doi.org/10.1163/15718166-12342052.

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Abstract This article analyses the Brey judgment of the eu Court of Justice, in which the cj had to rule on a claim for a social assistance benefit in a host Member State by an economically inactive migrant person. The legal context within which the Court had to deal with these questions differs from other cases regarding the politically highly sensitive question of the right to access to social benefits for economically inactive migrant Union citizens. It had to deal with the interpretation of the provisions in Social Security Coordination Regulation 883/2004 on the so-called ‘special non-contributory cash benefits’. This article examines the judgment in the light of previous political compromises and agreements on the relationship between Regulation 883/2004 and Citizens Directive 2004/38. It also looks into the consequences of the judgment for the concept of ‘social assistance’ in both these instruments and for the concept of ‘conflict rule’ in Regulation 883/2004. The issue of what claim should be considered as an ‘unreasonable burden’ on the host State’s social assistance system under Directive 2004/38 is assessed in more detail. The conclusion of the article is that this judgment has not only overruled previous political compromises but has also created more confusion than ever on the entitlement to social minimum benefits for economically inactive eu migrants.

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Salas Porras, María. "RECIENTES INTERPRETACIONES JURISPRUDENCIALES DEL REGLAMENTO 883/2004 SOBRE COORDINACIÓN EUROPEA DE LOS SISTEMAS NACIONALES DE SEGURIDAD SOCIAL." E-REVISTA INTERNACIONAL DE LA PROTECCION SOCIAL 5, n.º 2 (2020): 146–72. http://dx.doi.org/10.12795/e-rips.2020.i02.08.

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The study of the European jurisprudence is essential to understand the legal dynamics underlying the application of European regulations. This is not only due to the complementary role that such pronouncements play, but especially because the legal-political reality that is Europe makes the Court of Justice one of the key pillars for continuing to advance its construction. Based on this idea, our essay abounds in the review of the most recent pronouncements made by the CJEU on coordination of national Social Security systems based on Regulation 883/2004, which allows us to present results that, without neglecting the economic sphere, increasingly seem to point more to the social.

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van Ooij, Eva. "Highly mobile workers challenging Regulation 883/2004: Pushing borders or opening Pandora’s box?" Maastricht Journal of European and Comparative Law 27, n.º 5 (21 de setembro de 2020): 573–97. http://dx.doi.org/10.1177/1023263x20940137.

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This research paper aims to highlight hurdles that EU citizens may encounter when exercising their social security rights while working across borders. With the focus on the worker who is highly mobile in the sense of performing various work activities in two or more Member States, the paper analyses how the current system of coordination copes with the increasing mobility in the European labour market. On the basis of an illustrative case, it demonstrates where and explains why high mobility leads to legal and practical ambiguities due to the different interpretations of the rules determining the applicable law, particularly Article 13 of Regulation 883/2004.

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Melin, Pauline, e Susanne Sivonen. "Overview of recent cases before the Court of Justice of the European Union (September 2021-December 2021)". European Journal of Social Security 24, n.º 1 (19 de fevereiro de 2022): 58–67. http://dx.doi.org/10.1177/13882627221076869.

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The concept of ‘working time’ for a period of stand-by time according to a stand-by system applicable to firefighters was interpreted by the Court in MG (C-214/20). In the Y case (C-636/19), the Court interpreted the concept of ‘insured person’ for the purpose of reimbursement of healthcare costs under Directive 2011/24. In the TS case (C-538/19), the Court dealt with another cross-border healthcare case. This time the question was whether a Member State can require an authorisation for cross-border healthcare to be subject to the submission of a medical report drawn up by a doctor from its national public health insurance system in light of Article 20 of Regulation 883/2004 and Article 56 TFEU. In ASGI and APN (C-462/20), the exclusion of third-country nationals from the eligibility to the Italian family card was under scrutiny. In SC (C-866/19), the Court clarified that the principle of aggregation applies to the calculation of the theoretical amount of benefit but not to the calculation of the actual amount of benefit under Article 52(1)(b) of Regulation 883/2004. In K (C-285/20), the Court held that being on sick leave and receiving sickness benefits can be considered as equivalent to the pursuit of an economic activity for the purpose of applying the rules on unemployment benefits for wholly unemployed frontier workers under Article 65(2) and (5) of Regulation 883/2004.

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Verschueren, Herwig. "Special Non-Contributory Benefits in Regulation 1408/71, Regulation 883/2004 and the Case Law of the ECJ". European Journal of Social Security 11, n.º 1-2 (março de 2009): 217–34. http://dx.doi.org/10.1177/138826270901100111.

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Paskalia, Vicki. "The (IN)Visibility of Gender in the New Regulation". European Journal of Social Security 7, n.º 3 (setembro de 2005): 197–226. http://dx.doi.org/10.1177/138826270500700302.

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This article looks at the new co-ordination Regulation 883/04 from a gender perspective. The focus is on the provisions of the Regulation concerning its personal scope and some of its fundamental principles. The article considers whether these provisions function satisfactorily with regard to workers (often female) who have interrupted work because of child-rearing; as well as with regard to former spouses, who are covered by the Regulation in their capacity as family members of a Community worker, after the termination of their marriage. The article argues that, although the Reg. 883/03 provides some improvement with regard to the first category, namely workers interrupting work because of child-rearing, a great deal remains to be done. It also notes that no attention at all has been paid to the issue of marriage dissolution, qnd that this makes the situation of former spouses very uncertain and vulnerable. Finally, the article argues that the development of a gender dimension within the framework of the law of co-ordination is necessary in order to adjust the Regulation to new situations and for the satisfactory protection of a considerable number of persons, mainly women, who find themselves in situations such as those above.

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Singla, Amika, Ali Esmaili, Nikhil Bansal, Seema Saksena, Ravinder K. Gill, Waddah A. Alrefai, Krishnamurthy Ramaswamy e Pradeep K. Dudeja. "883 Transcriptional Regulation of Intestinal Apical Cl−/OH− Exchanger DRA By Lysophosphatidic Acid (LPA)". Gastroenterology 136, n.º 5 (maio de 2009): A—136. http://dx.doi.org/10.1016/s0016-5085(09)60612-0.

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Ning, W., A. Muroyama e T. Lechler. "883 Mechanical regulation of stem cell proliferation and fate decisions by their differentiated daughters". Journal of Investigative Dermatology 139, n.º 5 (maio de 2019): S153. http://dx.doi.org/10.1016/j.jid.2019.03.959.

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Melin, Pauline. "Overview of recent cases before the Court of Justice of the European Union (October 2019-January 2020)". European Journal of Social Security 22, n.º 1 (março de 2020): 64–70. http://dx.doi.org/10.1177/1388262720911530.

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During the period of reporting (1 October 2019-31 January 2020), six judgments are worth noting in the area of EU social security law. In Safeway, the Court had to decide whether Article 119 of the EC Treaty on equal treatment precluded a measure ending discrimination through the fixing, with retroactive effect, of a uniform normal pension age equal to that of the members within the previously disadvantaged category. In Bocero Torrico, the question related to the obligation on Member States, under Regulation 883/2004, to take into account equivalent benefits acquired in other Member States for the purpose of calculating an early retirement pension. WA concerned a discriminatory law that granted a pension supplement solely to women. UB was about a discriminatory law that granted additional benefits for sportspersons based on their citizenship. In ZP, the question concerned Article 62 of Regulation 883/2004 dealing with the calculation of unemployment benefits. Finally, in Pensions-Sicherungs-Verein, the Court had to interpret Article 8 of Directive 2008/94 in the context of a reduction of pension benefits following the insolvency of the employer.

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Guerrero Padrón, Thais. "INGRESO MÍNIMO VITAL Y NACIONALES BRITÁNICOS EN ESPAÑA EN TIEMPOS DEL BREXIT." E-REVISTA INTERNACIONAL DE LA PROTECCION SOCIAL 5, n.º 2 (2020): 60–76. http://dx.doi.org/10.12795/e-rips.2020.i02.04.

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As from 1 January 2021, after the end of the transitional period imposed by the EU-UK Withdrawal Agreement, the UK will be for all purposes a third State and its nationals considered as “foreigners”. The change of status of the UK raises interesting questions regarding the social security rights of EU citizens and UK nationals. This paper deals with the possibility of access to the Minimum Living Income benefit for British nationals residing in Spain, either under the Spanish immigration laws or within the framework of the EU Regulations on the Coordination of Social Security systems. As a core issue, the identification of the Minimum Life Income benefit with the special non-contributory benefits of Article 70 of Regulation 883/2004 is argued. To this respect, the lack of inclusion of the Spanish benefit in Annex X can be considered as a serious oversight, possibly rectifiable by regulation and very necessary to avoid the conflict that this lack of clarification could generate

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van der Mei, Anne Pieter. "Overview of recent cases before the court of justice of the European Union (April−September 2017)". European Journal of Social Security 19, n.º 4 (dezembro de 2017): 353–62. http://dx.doi.org/10.1177/1388262717745741.

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This contribution presents an overview of the case law of the Court of Justice of the European Union in the period April–September 2017 on social security matters. The relevant rulings concern first and foremost the rules determining the applicable legislation as enshrined in Regulation 883/2004 and Regulation 1408/71. In addition, the Court of Justice has delivered important rulings concerning posted worker and the binding effect of A1 certificates, the social security rights of third country nationals holding a single-permit and the protection of social rights in the context of financial crisis and austerity measures.

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Chelakova, Yulia A., e Natalya A. Nikonoshina. "Features of immune regulation in working at the enterprise for the production of phthalic anhydride". Russian Journal of Occupational Health and Industrial Ecology 60, n.º 11 (3 de dezembro de 2020): 881–83. http://dx.doi.org/10.31089/1026-9428-2020-60-11-881-883.

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Introduction. Employees of the chemical industry engaged in the production of phthalic anhydride are characterized by multi-level morphofunctional disorders of the health profile, characterized by an imbalance in the regulation of metabolism, sensitization of the body, membranotoxic effects, and the formation of secondary immunodeficiency. The aim of study was to assess the immune status of workers engaged in the production of phthalic anhydride. Materials and methods. The observation group included workers in contact with phthalic anhydride (31 persons). The comparison group consisted of administrative employees who were not in contact with phthalic anhydride (23 persons). Chemical exposure in the workplace is associated with the presence of phthalic anhydride - a harmful substance of hazard class 2. The full lymphocytes was performed on a flow cytometer FACSCalibur company "Becton Dickinson". The expression level of p53 and TNFR was determined using the corresponding MCAT. Cancer markers (CA 19-9, CEA, PSA) were determined by enzyme immunoassay. Changes in the content of phthalic anhydride-specific IgE were determined in an allergosorbent test with an enzyme label. The statistical analysis was performed using the software package Statistica 6.0. The reliability of differences between the groups were considered significant at p<0.05. Results. A significant deficiency in the content of the CD95+ cell death receptor relative to the reference level was established (p<0.05). There is a significant overexpression of the TNFR receptor in relation to the norm and the comparison group (2.5 times) (p<0.05). The level of p53 expression was significantly increased in relation to the comparison group (p<0.05). The observation group had an increased level of cancer markers CA 19-9, CEA, and PSA relative to the comparison group (p<0.05). There was a significantly increased content of IgE specific to phthalic anhydride (by its metabolite phthalic acid) in relation to the reference level (in 61.6%) and the comparison group (p<0.05). The results obtained verify the information in the scientific literature about the nature of the effect of phthalic anhydride on the immune system, its ability to cause allergic reactions (IgE specific to phthalic anhydride). Conclusions. Thus, the employees employed at the phthalic anhydride production facility had significantly reduced CD95+ levels, overexpression of TNFR, p53, CA 19-9, CEA, PSA, as well as hyperproduction of phthalic anhydride-specific reagins, which indicates insufficient immune control over the duration of the cell life cycle, and does not exclude the development of allergic, autoimmune, and oncoproliferative scenarios of production-related pathology.

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Sánchez-Rodas Navarro, Cristina. "EDITORIAL: (IN)SUFFICIENT LEGAL BASIS FOR THE PROPOSAL FOR REFORM OF REGULATION 883/2004 PRESENTED BY THE EUROPEAN COMMISSION ON 13.12.2016". E-REVISTA INTERNACIONAL DE LA PROTECCION SOCIAL 2, n.º 2 (2017): 3. http://dx.doi.org/10.12795/e-rips.2017.i02.02.

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Weber, Helmut. "CRITICAL VIEW ON SOME ISSUES OF THE EU-COMMISSION’S PROPOSAL FOR A REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL AMENDING REGULATION (EC) NO 883/2004 ON THE COORDINATION OF SOCIAL SECURITY SYSTEMS AND REGULATION (EC) NO 987/2009 LAYING DOWN THE PROCEDURE FOR IMPLEMENTING REGULATION (EC) NO 883/2004". E-REVISTA INTERNACIONAL DE LA PROTECCION SOCIAL 2, n.º 2 (2017): 4–17. http://dx.doi.org/10.12795/e-rips.2017.i02.03.

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Lazarova, Nikoleta. "Conditions for the Acquisition of the Right to Compensation under the Bulgarian Legislation and Compliance with the Terms of Regulation (EC) № 883/2004". International conference KNOWLEDGE-BASED ORGANIZATION 22, n.º 2 (1 de junho de 2016): 349–52. http://dx.doi.org/10.1515/kbo-2016-0059.

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Abstract This article is dedicated to the legal framework of the conditions for the acquisition of the right to compensation due to unemployment under the Social Security Code of the Republic of Bulgaria. Unemployment is one of the main problems of labour, making it the current object of study not only in the legal, but also in the economic theory and practice. In relation to the intended subject, Regulation (EC) № 883/2004 has also been scrutinized, as it presents rules for coordination of the national social security systems of the EU Member States.

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Verschueren, Herwig. "The Renewed EU Social Security Coordination in Regulation No. 883/2004 and Its Link with Bilateral Tax Agreements". EC Tax Review 21, Issue 2 (1 de abril de 2012): 98–111. http://dx.doi.org/10.54648/ecta2012010.

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This article gives a general outline of the new European coordination rules regarding social security in Regulation No. 883/2004 that came into effect on 1 May 2010. These rules have not been fundamentally changed compared to the previous rules in Regulation No. 1408/71. However, there are some important innovations, and the provisions have been simplified, rewritten, and adapted. As for the rules on the determination of the applicable legislation, the State of employment principle has been confirmed and even strengthened. In actual practice, the new rules and agreements on a better administrative collaboration between the Member States, inter alia, via electronic exchange of data, will be of the utmost importance. Yet, this new European social security coordination has not changed anything with regard to the lack of coordination with the rules on the determination of the applicable legislation in bilateral tax agreements. This can lead to situations in which a migrating person contributes in more than one State to the funding of social security that is sometimes considered to be an obstacle to the free movement of persons. However, both from the political and legal analyses in this article, it follows that a better coordination between the rules to determine the applicable legislation in social security and in tax matters will not come about easily and probable only on a case-by-case basis.

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TAKAHASHI, Hidetoshi, Kazuhiro ASANO, Satoshi NAKAMURA, Akemi ISHIDA-YAMAMOTO e Hajime IIZUKA. "Interferon-γ-dependent stimulation of human involucrin gene expression: STAT1 (signal transduction and activators of transcription 1) protein activates involucrin promoter activity". Biochemical Journal 344, n.º 3 (8 de dezembro de 1999): 797–802. http://dx.doi.org/10.1042/bj3440797.

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Involucrin is one of the precursor proteins of the cornified cell envelope of keratinocytes, and is expressed during the later stages of keratinocyte differentiation. Interferon-γ (IFN-γ), a pleiotropic cytokine with anti-proliferative and immunomodulatory activities, is also a potent inducer of squamous differentiation. Using cultured normal human keratinocytes (NHK cells) and simian virus 40-transformed human keratinocytes (SVHK cells), we investigated the effects of IFN-γ on involucrin gene expression. Expression of involucrin was increased by about 3-fold after treating NHK cells with IFN-γ (100 units/ml). Northern blot analyses revealed that IFN-γ increased the expression of involucrin mRNA. The fragment +42 to -2463 in the 5ʹ-flanking region of the human involucrin gene was subcloned into a luciferase reporter vector and the construct (p2463Luc) was transfected into SVHK cells. p2463Luc produced a 3-fold increase in luciferase activity after IFN-γ treatment. Sequence analysis detected two putative IFN-γ-responsive regions [G1 (positions -883 to -874) and G2 (-784 to -775)]. Deletion analyses of the p2463Luc vector revealed that the G1 region is critical for the IFN-γ-dependent up-regulation of the involucrin gene. Gel-shift analyses revealed that STAT1 (signal transduction and activators of transcription 1) protein bound to the G1 region and that involucrin promoter activity was augmented by transfection of a STAT1 expression vector in the presence of IFN-γ. In contrast, transfection of a STAT1 dominant-negative expression vector suppressed the IFN-γ-dependent up-regulation of involucrin promoter activity. These results indicate that IFN-γ stimulates expression of the human involucrin gene via the G1 (-883 to -874) region of the involucrin gene promoter.

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Schoukens, Paul, e Greta Gorissen. "Internal coordination of social security in federal Belgium". European Journal of Social Security 21, n.º 2 (31 de maio de 2019): 100–118. http://dx.doi.org/10.1177/1388262719845315.

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This article depicts the internal coordination of social security schemes, covered by EU Regulation no. 883/2004 in the federal state of Belgium. Since the first state reform in 1970, Belgium gradually evolved from a unitary into a federal state. Next to the federal level, there are two additional levels, the Communities and the Regions. Family allowances and long-term care insurance are, for instance, within the competence of the Communities. The article outlines the extent of federalism and decentralisation, the adjudication of competence between the federated entities and the financial arrangements between the federal state and the federated entities as well as the financial arrangements between the federated entities.

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Bologna, Silvio. "Internal coordination of social security in Italy". European Journal of Social Security 21, n.º 2 (31 de maio de 2019): 141–52. http://dx.doi.org/10.1177/1388262719847808.

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This contribution deals with the internal coordination of health care, long-term social care and social assistance schemes – covered by EU regulation no. 883/2004 – in Italy after the constitutional reform enacted in 2001, which significantly decentralised legislative and administrative machinery by strengthening the prerogatives of the Regions, especially in terms of organisation and funding of the services. This article seeks to demonstrate that, although the decentralisation of health care and long-term social care has been accompanied by mechanisms of internal coordination among the Regions (particularly in the field of inter-regional mobility), regional social assistance schemes providing money transfers lack any form of coordination.

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van der Mei, Anne Pieter, e Pauline Melin. "Overview of recent cases before the court of justice of the European Union (February 2019-June 2019)". European Journal of Social Security 21, n.º 3 (25 de agosto de 2019): 272–80. http://dx.doi.org/10.1177/1388262719870756.

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In the reporting period (February 2019-June 2019), the Court of Justice of the European Union did not deliver any ground breaking rulings that really altered existing coordination rules on social security. Nonetheless, the Court did rule in various interesting cases. These include the material scope of Regulation 883/2004 ( Dreyer), the rules determining the applicable legislation ( SF), invalidity benefits ( Vester), and family benefits ( Bogatu). In addition, the Court brought about clarification of the possibility of retaining worker status (and thus claiming social benefits as a worker) under Directive 2004/38 ( Tarola) and the right of Turkish nationals to export benefits under Decision 3/80 when returning to Turkey ( Coban).

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Sánchez-Rodas Navarro, Cristina. "TRIBUNA: (IN)SUFICIENTE FUNDAMENTO LEGAL PARA LA PROPUESTA DE REFORMA DEL REGLAMENTO 883/2004 PRESENTADA POR LA COMISÓN EUROPEA EL 13.12.2016". E-REVISTA INTERNACIONAL DE LA PROTECCION SOCIAL 2, n.º 2 (2017): 1–2. http://dx.doi.org/10.12795/e-rips.2017.i02.01.

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Golynker, Oxana. "EU coordination of social security from the point of view of EU integration theory". European Journal of Social Security 22, n.º 2 (junho de 2020): 110–37. http://dx.doi.org/10.1177/1388262720938154.

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This article comprises a study of the negotiation of the Commission’s proposal for amending Regulation (EC) No 883/2004 on the coordination of social security systems and Regulation (EC) No 987/2009 in the context of EU integration theories. This analysis is used to argue that the current integration stage in the coordination of social security is a complex phenomenon which displays elements of intergovernmentalism, neo-functionalism and post-functionalism. The negotiation process highlights the disagreements between the key players which may have important consequences for the future of EU regulation in the area of coordination of social security. The article concludes that the signs of intergovernmentalism are prevalent, as evident in the attention the Commission has given to the concerns of the Member States, the negotiating position of the Council, and the vote of the European Parliament which failed to approve the proposal at the first reading. This prevalence has led to a pause in the reform of the coordination regulations and may eventually lead to compromises that will weaken the progress of integration in the future. At the same time, the article argues that the theory of post-functionalism is important in explaining the phenomenon of Brexit with regard to the UK’s position in the negotiation of the Commission’s proposal and its future relevance for UK and EU citizens affected by the UK’s departure from the EU. The article concludes that disintegration along the lines of post-functionalism should not prevent the reintegration of the UK into the EU coordination of social security schemes, but may reinforce the prevalence of intergovernmentalism.

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Paju, Jaan. "Case C-181/19, Jobcenter Krefeld: The End of the Union Citizenship as Previously Understood?" Review of European Administrative Law 14, n.º 4 (17 de dezembro de 2021): 47–64. http://dx.doi.org/10.7590/187479821x16364535488046.

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The European Court of Justice has taken a restrictive approach vis-à-vis economically inactive Union citizens ever since its rulings Brey and Dano. In a recent preliminary ruling, Case C-181/19 Jobcenter Krefeld, the Court confirms this approach with regard to social security benefits that resemble social assistance. Such benefits fall, just as the Court in held in Brey and Dano, under the Citizenship Directive and can be made dependent upon a right to reside. Thereby, the Court holds that the Citizenship Directive overrule Regulation 883/2004, that coordinates social security benefits, and its equal treatment principle which rule out additional residence requirements. However, the Court clarifies that if there is a right to reside on basis of Regulation 492/2011, such a right overrides the more restrictive right to reside that follows from the Citizenship Directive. Different standards seem to apply to economically active Union citizens and economically inactive Union citizens. Challenges lie ahead for the Member States' administrations as different authorities apply the respective Union law instruments.

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Devetzi, Stamatia, e Jean McHale. "Health and long-term care benefits and the proposed revised coordination regulation: A brave new world or much ado about nothing?" European Journal of Social Security 22, n.º 2 (junho de 2020): 180–95. http://dx.doi.org/10.1177/1388262720931229.

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This article examines the implications of the proposed Revised Coordination Regulation for long-term care benefits. First, it explores what is meant by ‘long-term care’. This sets the debate around access to long-term care in the context of developments regarding the safeguarding of fundamental human rights for those with disabilities and increasing international concern regarding the human rights of older persons. Secondly, it charts the response at the EU level to calls for safeguards in long-term care. It contrasts this with the disparate approaches taken at the Member State level. Thirdly, it examines the development of CJEU jurisprudence in this area. Fourthly, it considers the proposals for amending Regulation 883/2004 and its inclusion of long-term care. It concludes by questioning the extent to which these proposed developments will provide a radical change of approach, one which may indeed impact on expectations of long-term care at the individual Member State level and asks whether the drafting of an approach taken in relation to the proposals suggests that, ultimately, this may be little more than ‘much ado about nothing’.

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Bekkedal, Tarjei. "The Internal, Systemic and Constitutional Integrity of EU Regulation 883/2004 on the Coordination of Social Security Systems: Lessons from a Scandal". Oslo Law Review 7, n.º 03 (17 de dezembro de 2020): 145–67. http://dx.doi.org/10.18261/issn.2387-3299-2020-03-02.

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Madzharov, Ivan. "Reports and the their annexes prepared by the European anti-fraud office in the pre-trial criminal proceedings". Law Journal of New Bulgarian University 18, n.º 1 (6 de julho de 2022): 23–31. http://dx.doi.org/10.33919/ljnbu.22.1.2.

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The article is related to а specific procedure – the inclusion and application of the reports and their annexes prepared by the European anti-fraud office (OLAF) in the Bulgarian pre-trial proceedings. The reports and their annexes are prepared according to Regulation 883/2013 which regulates all the activities of OLAF in the EU and third countries. The reports and their annexes are a specific tool for our legislation and they can be used in the pre-trial proceedings as written proof tools according to the Bulgarian Criminal Procedure Code. This article explains the OLAF’s structure and the practical application of the OLAF’s reports and their annexes during the pre-trial investigation and focuses on the main problems which are encountered in the investigation practice related to their application as well.

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van der Mei, Anne Pieter. "Overview of recent cases before the Court of Justice of the European Union (July – October 2018)". European Journal of Social Security 20, n.º 4 (dezembro de 2018): 364–73. http://dx.doi.org/10.1177/1388262718822554.

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In the reporting period July-October 2018, the Court of Justice of the European Union (CJEU) delivered three rulings ( Alpenrind, Walltopia, and Commission v Belgium) concerning the conflict rule for posted workers as contained in Article 12 of Regulation 883/2004. The CJEU clarified the meaning of the `non-replacement condition', the legal status of workers who are recruited for the sole purpose of being posted to another Member State as well as procedural aspects relating to A1 certificates. In addition, the CJEU delivered judgments on the portability of personal care benefits (A), the application of the prohibition of discrimination on grounds of disability to social security provisions contained in collective agreements ( Bedi) and the protection of supplementary pension claims in the event of insolvency of the employer ( Grenville Hampshire).

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Mukhametzaripov, I. А., R. M. Nurgaleev e M. M. Mardanshin. "The role of the Qadiyat of the Muslim Religious Board in the modern Muslim Community of Tatarstan". Minbar. Islamic Studies 15, n.º 4 (11 de janeiro de 2023): 869–83. http://dx.doi.org/10.31162/2618-9569-2022-15-4-869-883.

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The study of the activities of Muslim institutions in the field of regulation of social relations in a secular state is of particular interest in terms of religious associations’ adaptation. The authors explore the structure of the Qadiyat of the Muslim Religious Board of the Republic of Tatarstan, the powers of qadis, the main directions of their activities and give examples of the consideration of cases by Muslim judges, analyzing regulations and publications within the framework of the structural-functional approach. Tatarstan qadis as members of the Qadis Council and as regional Muslim judges perform control, advisory, mediation and arbitration functions. Qadis deal with marriage and family matters, inheritance disputes, settle conflicts in the business sphere, consult on Sharia issues and are engaged in the preservation and strengthening of Tatar traditions. One of the promising directions for the development of the institution of Qadiyat as an instrument for pre-trial settlement of disputes is the creation of a mediation and arbitration body on its basis that can help a wide range of believers to resolve conflicts according to the norms of Islam and Russian laws.

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Bian, Jin-Song, Anna Kagan e Thomas V. McDonald. "Molecular analysis of PIP2 regulation of HERG and IKr". American Journal of Physiology-Heart and Circulatory Physiology 287, n.º 5 (novembro de 2004): H2154—H2163. http://dx.doi.org/10.1152/ajpheart.00120.2004.

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We previously reported that cloned human ether-à-go-go-related gene (HERG) K+ channels are regulated by changes in phosphatidylinositol 4,5-bisphosphate (PIP2) concentration. Here we investigated the molecular determinants of PIP2 interactions with HERG channel protein. To establish the molecular nature of the PIP2-HERG interaction, we examined a segment of the HERG COOH terminus with a high concentration of positively charged amino acids (nos. 883–894) as a possible site of interaction with negatively charged PIP2. When we excised deletion-HERG (D-HERG) or mutated methionine-substituted-HERG (M-HERG) this segment of HERG to neutralize the amino acid charge, the mutant channels produced current that was indistinguishable from wild-type HERG. Elevating internal PIP2, however, no longer accelerated the activation kinetics of the mutant HERG. Moreover, PIP2-dependent hyperpolarizing shifts in the voltage dependence of activation were abolished with both mutants. PIP2 effects on channel-inactivation kinetics remained intact, which suggests an uncoupling of inactivation and activation regulation by PIP2. The specific binding of radiolabeled PIP2 to both mutant channel proteins was nearly abolished. Stimulation of α1A-adrenergic receptors produced a reduction in current amplitude of the rapidly activating delayed rectifier K+ current (the current carried by ERG protein) from rabbit ventricular myocytes. The α-adrenergic-induced current reduction was accentuated by PKC blockers and also unmasked a depolarizing shift in the voltage dependence of activation, which supports the conclusion that receptor activation of PLC results in PIP2 consumption that alters channel activity. These results support a physiological role for PIP2 regulation of the rapidly activating delayed rectifier K+ current during autonomic stimulation and localize a site of interaction to the COOH-terminal tail of the HERG K+ channel.

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Zavando Cerda, Daniela, e Laura Gómez Urquijo. "Improving the protection of migrant workers with work histories in the European Union and Ibero‐America: Enhancing the coordination of international social security instruments". International Social Security Review 76, n.º 3 (julho de 2023): 25–45. http://dx.doi.org/10.1111/issr.12338.

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AbstractMigration affects almost every nation, emphasizing the need to guarantee social security rights for all migrants and their families. This article focuses on the rights of workers who migrate between the countries of the European Union (EU) and the Ibero‐American community. In the EU, social security systems are increasingly coordinated through Regulation No. 883/2004 and its Implementing Regulation No. 987/2009. In the Ibero‐American community, coordination is sought through the Ibero‐American Social Security Convention. Despite convergence between these two international instruments, coordination is still lacking between them. This article presents a comparative analysis to articulate the necessary mechanisms to guarantee coordination, to respect the social security rights of migrant workers. We focus on the cooperation and coordination between regional as well as national systems, specifically looking at the need for and aims of a rapprochement between these two major international coordination instruments to provide greater EU‐Ibero‐American cooperation. Finally, the importance of promoting greater international cooperation in social security policy and administration is highlighted, to engender the adequate protection of the rights as well as the free movement of migrant workers.

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Gupta, Ashish K., e Bruce C. Kone. "USF-1 and USF-2 trans-repress IL-1β-induced iNOS transcription in mesangial cells". American Journal of Physiology-Cell Physiology 283, n.º 4 (1 de outubro de 2002): C1065—C1072. http://dx.doi.org/10.1152/ajpcell.00100.2002.

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Transcriptional activation of the inducible nitric oxide synthase (iNOS) gene requires multiple interactions of cis elements and trans-acting factors. Previous in vivo footprinting studies (Goldring CE, Reveneau S, Algarte M, and Jeannin JF. Nucleic Acids Res 24: 1682–1687, 1996) of the murine iNOS gene demonstrated lipopolysaccharide-inducible protection of guanines in the region −904/−883, which includes an E-box motif. In this report, by using site-directed mutagenesis of the −893/−888 E-box and correlating functional assays of the mutated iNOS promoter with upstream stimulatory factor (USF) DNA-binding activities, we demonstrate that the −893/−888 E-box motif is functionally required for iNOS regulation in murine mesangial cells and that USFs are in vivo components of the iNOS transcriptional response complex. Mutation of the E-box sequence augmented the iNOS response to interleukin-1β (IL-1β) in transiently transfected mesangial cells. Gel mobility shift assays demonstrated that USFs cannot bind to the −893/−888 E-box promoter region when the E-box is mutated. Cotransfection of USF-1 and USF-2 expression vectors with iNOS promoter-luciferase reporter constructs suppressed IL-1β-simulated iNOS promoter activity. Cotransfection of dominant-negative USF-2 mutants lacking the DNA binding domain or cis-element decoys containing concatamers of the −904/−883 region augmented IL-1β stimulation of iNOS promoter activity. Gel mobility shift assays showed that only USF-1 and USF-2 supershifted the USF protein-DNA complexes. These results demonstrated that USF binding to the E-box at −893/−888 serves to trans-repress basal expression and IL-1β induction of the iNOS promoter.

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Hasudungan, P., I. Irham e A. W. Utami. "The impact of el niño southern oscillation and covid-19 on the rice price dynamics in Indonesia: the vector error correction model approach". IOP Conference Series: Earth and Environmental Science 883, n.º 1 (1 de outubro de 2021): 012061. http://dx.doi.org/10.1088/1755-1315/883/1/012061.

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Abstract Half of the world's population makes rice a crop of focus because it has many opportunities in the future. However, there are disruptors for rice development in 2020, which are climate variability and COVID-19 Pandemics. El Nino-Southern Oscillation (ENSO) is a climate variability that can threaten the rice price dynamics. Besides that, COVID-19 also has implications for rice price dynamics. The objectives of this paper are: (1) to empirically study the impact of the El Nino-Southern Oscillation on rice price dynamics and (2) to analyze the effect of COVID-19 pandemics on rice price in Indonesia. The study utilized the vector error correction model (VECM) estimation method and the variables used were sea surface temperature (SST), COVID-19 daily cases, rice price, rice production, and rice price regulation. The result is that El Nino has a positive effect on rice prices, which can increase the price level. The opposite is true also for a La Nina shock. COVID-19 also has a positive impact on the daily cost of rice. The results of this study ought to be of interest to rice producers in Indonesia, as well as processors and intermediaries in the rice markets.

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Weerepas, Marjon J. G. A. M., e Anouk H. H. Bollen-Vandenboorn. "Enhancing Worker Mobility via the Mobility Directive: Arrange the Tax Consequences for Supplementary Pension Rights Now!" EC Tax Review 24, Issue 1 (1 de fevereiro de 2015): 34–42. http://dx.doi.org/10.54648/ecta2015004.

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On 21 May 2014 the Mobility Directive entered into force. The Directive stipulates minimum conditions for enhancing worker mobility between Member States by improving the acquisition and preservation of supplementary pension rights. The aim of the European Commission is to improve the mobility of workers between Member States. The goal of this Directive is to reduce the impediments created by supplementary pension scheme rules related to employment relationships. Coordination and guidance exist at the European level in the fields of social security and pension law. Without a change in tax law rules, however, labour mobility will continue to be hampered. Where it is clear in Regulation 883/2004, Council Directive (EC) No. 98/49/EC and the Mobility Directive what in general terms qualifies as a pension, such qualification for tax purposes remains complicated. Due to the fiscal sovereignty of Member States, each Member State is free to apply its own conditions and requirements before recognizing a supplementary pension scheme. This contribution will address the entry into force of the Mobility Directive, the coherence of coordination rules concerning statutory pension rights and directives relating to supplementary pension rights, and will explore the extent to which at the European level in particular a connection can be made to fiscal regulation in order to optimize labour mobility.

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Lach, Daniel Eryk. "O procedurze i skutkach wycofania zaświadczenia A1 raz jeszcze. Glosa do wyroku TSUE z 16 listopada 2023 r., C-422/22". Studia Prawa Publicznego, n.º 2 (46) (28 de junho de 2024): 145–59. http://dx.doi.org/10.14746/spp.2024.2.46.7.

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ZUS’s withdrawal of the A1 certificate regarding an employee delegated to work in the EU resulted in practical problems related to including this employee in the appropriate social security system of the place of work. As a result, in its jurisprudence the Supreme Court formulated a controversial requirement to precede the withdrawal of the A1 certificate by ZUS by agreeing with the institution of the place of work on retroactive subjection to the applicable legislation. This position, which is assessed critically in the literature, was rejected by the Court of Justice of the EU in its judgment of November 16, 2023, C-422/22. The Court found that Articles 5, 6 and 16 of Regulation (EC) No 987/2009 must be interpreted as meaning that the institution that issued an A1 certificate which, following a review on its own initiative of the evidence on which the issue of that certificate is based, finds that evidence to be incorrect, may withdraw that certificate without first initiating the dialogue and conciliation procedure laid down in Article 76(6) of Regulation (EC) No 883/2004 with the competent institutions of the Member States concerned with a view to determining the national legislation applicable. The subject of the gloss is an approving discussion of this judgement.

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Zhou, Yaqing, Rongli Jiang, Yali Jiang, Yahong Fu, Yerbolat Manafhan, Jinfu Zhu e Enzhi Jia. "Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis". Cells 11, n.º 19 (24 de setembro de 2022): 2980. http://dx.doi.org/10.3390/cells11192980.

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Objectives: N6-methylladenosine (m6A) modification has not been fully studied in atherosclerosis. The objectives of this study were to investigate differentially expressed m6A methylated peaks and mRNAs, along with the regulatory role of methyltransferase 3 (METTL3) in pathological processes of atherosclerosis. Methods: The pathological models of human coronary artery smooth muscle cells (HCASMCs) were induced in vitro. The differentially expressed mRNAs and m6A peaks were identified by RNA-Seq and meRIP-Seq. The potential mechanisms were analyzed via bioinformatic assays. Methylases expression was tested by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting (WB) in HCASMCs, and by immunohistochemical assays in 40 human coronary arteries. The knockdown of METTL3 expression in cells was performed by siRNA transfection, and cell proliferation and migration were detected after transfection. Results: We identified 5121 m6A peaks and 883 mRNAs that were expressed differentially in the pathological processes of HCASMCs. Bioinformatic analyses showed that the different m6A peaks were associated with cell growth and cell adhesion, and the 883 genes showed that the extracellular matrix and PI3K/AKT pathway regulate the processes of HCASMCs. Additionally, 10 hub genes and 351 mRNAs with differential methylation and expression levels were found. METTL3 was upregulated in the arteries with atherosclerotic lesions and in the proliferation and migration model of HCASMCs, and pathological processes of HCASMCs could be inhibited by the knockdown of METTL3. The mechanisms behind regulation of migration and proliferation reduced by siMETTL3 are concerned with protein synthesis and energy metabolism. Conclusions: These results revealed a new m6A epigenetic method to regulate the progress of atherosclerosis, which suggest approaches for potential therapeutic interventions that target METTL3 for the prevention and treatment of coronary artery diseases.

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