Literatura científica selecionada sobre o tema "Recherche de ligands/substrats"
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Artigos de revistas sobre o assunto "Recherche de ligands/substrats"
De la SRLF, CRT, Peter Radermacher, Mehdi Oualha, Laure Stiel, Jolien Vandewalle, Youenn Jouan, Eric Fontaine et al. "Le métabolisme énergétique au cours des états critiques : actes du 8ème Séminaire de Recherche Translationnelle de la Société de Réanimation de Langue Française (Paris, 2 décembre 2022)". Médecine Intensive Réanimation 32, n.º 4 (22 de dezembro de 2023): 417–28. http://dx.doi.org/10.37051/mir-00184.
Texto completo da fonteMpadi, Nkwe Charles, e Daniel-Bienvenu Mada Bangala. "Utilisation du champignon Pleurotus sajor-caju pour la délignification d’un substrat à base des hampes florales de bananiers (Musa spp.) et la production des carpophores comestibles". International Journal of Biological and Chemical Sciences 13, n.º 7 (12 de fevereiro de 2020): 3164–76. http://dx.doi.org/10.4314/ijbcs.v13i7.16.
Texto completo da fonteGantrel, Martine. "Albertine ou l'étrangère : une nouvelle interprétation des « cris de Paris » dans La Prisonnière". Revue d'histoire littéraire de la France o 100, n.º 1 (1 de janeiro de 2000): 3–26. http://dx.doi.org/10.3917/rhlf.g2000.100n1.0003.
Texto completo da fonteGbian, Douweh Leyla, e Abdelwahab Omri. "Évaluation de l'activité antimicrobienne du Phénylalanine-arginine β-naphthylamide en combinaison avec des aminoglycosides et des macrolides sur des souches de Pseudomonas aeruginosa isolées de patients atteints de la Fibrose kystique". Actes de la Journée des Sciences et Savoirs, n.º 24 (22 de março de 2019): 41–55. http://dx.doi.org/10.28984/actes_acfas.v0i24.306.
Texto completo da fonteWoolschlager, J., e B. E. Rittmann. "Que mesurent les tests de CODB et de COA ?" Revue des sciences de l'eau 8, n.º 3 (12 de abril de 2005): 371–85. http://dx.doi.org/10.7202/705229ar.
Texto completo da fonteMorsli, Boutkhil, Mohammed Habi e Mohamed Meddi. "Dynamique de l’érosion en zone méditerranéenne algérienne : facteurs explicatifs de variation du ruissellement et de l’érosion sous différentes occupations du sol". Revue des sciences de l’eau 26, n.º 2 (3 de junho de 2013): 89–105. http://dx.doi.org/10.7202/1016061ar.
Texto completo da fonteBigot, J., E. Poucet, A. Moreau, C. Hennequin, L. Guillot, H. Corvol, T. Fontaine e V. Balloy. "Recherche des récepteurs cellulaires et des ligands fongiques impliqués dans la synthèse d’IL-8 par les cellules épithéliales bronchiques infectées par Aspergillus fumigatus". Revue des Maladies Respiratoires 41, n.º 3 (março de 2024): 208–9. http://dx.doi.org/10.1016/j.rmr.2024.01.056.
Texto completo da fonteSpalletta, Marica, e Lorenzo Ugolini. "La gouvernance du journalisme en Italie. Structures, faiblesses, anomalies." Sur le journalisme, About journalism, Sobre jornalismo 3, n.º 2 (15 de dezembro de 2014): 116–31. http://dx.doi.org/10.25200/slj.v3.n2.2014.187.
Texto completo da fonteBernard, Antoine, David Henault, Sandy Pelletier, Pamela Thebault, Benoit Barrette e Simon Turcotte. "302 Characterization of TIGIT and PVR expression in colorectal liver metastases". Journal for ImmunoTherapy of Cancer 9, Suppl 2 (novembro de 2021): A325. http://dx.doi.org/10.1136/jitc-2021-sitc2021.302.
Texto completo da fonteKhemis, Sabri Ben. "Mesure térahertz de faibles épaisseurs et détection de défauts aux interfaces pour les revêtements industriels : Avancées et applications". e-journal of nondestructive testing 28, n.º 9 (setembro de 2023). http://dx.doi.org/10.58286/28483.
Texto completo da fonteTeses / dissertações sobre o assunto "Recherche de ligands/substrats"
Perrot, Thomas. "Diversité fonctionnelle des systèmes de détoxication chez les champignons lignolytiques". Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0140/document.
Texto completo da fonteWood decaying fungi play an important role in the carbon cycle by participating in the recycling of organic matter. In addition to their ability to mineralize lignocellulosic biomass, these organisms have the ability to degrade potentially toxic molecules released during this process. Their detoxification system involves several multigenic families including glutathione transferases. These ubiquitous enzymes are grouped into several classes in the fungal kingdom, some of them are widespread in these fungi. In this context, the main objective of this thesis was to understand the functions of glutathione transferases of the Omega class (GSTOs) extended in Trametes versicolor, a white rot fungus. A biochemical and structural approach was led using nine recombinant proteins. Firstly, enzymatic characterization of these isoforms was performed using synthetic substrates, the obtained results demonstrating a similarity of catalytic properties. Then, using a library of pure molecules and another one of complex mixtures from different forest species, a high throughput screening method was applied to identify potential ligands for these enzymes. The resolution of the three-dimensional structure of three isoforms demonstrated the homodimeric state of these proteins and the involvement of two binding sites in the recognition of these ligands: the H site (present in each monomer) and the L site (at the dimer interface). For example, the isoform TvGSTO3S is able to bind several hydroxybenzophenones in its H site, but also a flavonoid, dihydrowogonin. In this case, this interaction with a natural ligand derived from wild-cherry tree extract was demonstrated by an affinity crystallography approach. On the other hand, co-crystallization experiments detected two molecules of another flavonoid, naringenin, in the L site of the isoform TvGSTO6S. Finally, a specific interaction involving the H and L sites of the isoform TvGSTO2S was demonstrated with oxyresveratrol. Structural analysis revealed that the presence of both configurations of the stilbene in the protein: the trans configuration in the H site and the cis configuration in the L site. Thus, despite partial functional redundancy, this research demonstrated the existence of a specific pattern of interactions for each tested isoform. The expansion of the Omega class could indicate that these enzymes are involved in the adaptation of the fungus in its environment. Indeed, the ligands identified during this work suggest that the "ligandin" properties of TvGSTOs play a role in detoxifying wood degradation products
Perrot, Thomas. "Diversité fonctionnelle des systèmes de détoxication chez les champignons lignolytiques". Electronic Thesis or Diss., Université de Lorraine, 2018. http://www.theses.fr/2018LORR0140.
Texto completo da fonteWood decaying fungi play an important role in the carbon cycle by participating in the recycling of organic matter. In addition to their ability to mineralize lignocellulosic biomass, these organisms have the ability to degrade potentially toxic molecules released during this process. Their detoxification system involves several multigenic families including glutathione transferases. These ubiquitous enzymes are grouped into several classes in the fungal kingdom, some of them are widespread in these fungi. In this context, the main objective of this thesis was to understand the functions of glutathione transferases of the Omega class (GSTOs) extended in Trametes versicolor, a white rot fungus. A biochemical and structural approach was led using nine recombinant proteins. Firstly, enzymatic characterization of these isoforms was performed using synthetic substrates, the obtained results demonstrating a similarity of catalytic properties. Then, using a library of pure molecules and another one of complex mixtures from different forest species, a high throughput screening method was applied to identify potential ligands for these enzymes. The resolution of the three-dimensional structure of three isoforms demonstrated the homodimeric state of these proteins and the involvement of two binding sites in the recognition of these ligands: the H site (present in each monomer) and the L site (at the dimer interface). For example, the isoform TvGSTO3S is able to bind several hydroxybenzophenones in its H site, but also a flavonoid, dihydrowogonin. In this case, this interaction with a natural ligand derived from wild-cherry tree extract was demonstrated by an affinity crystallography approach. On the other hand, co-crystallization experiments detected two molecules of another flavonoid, naringenin, in the L site of the isoform TvGSTO6S. Finally, a specific interaction involving the H and L sites of the isoform TvGSTO2S was demonstrated with oxyresveratrol. Structural analysis revealed that the presence of both configurations of the stilbene in the protein: the trans configuration in the H site and the cis configuration in the L site. Thus, despite partial functional redundancy, this research demonstrated the existence of a specific pattern of interactions for each tested isoform. The expansion of the Omega class could indicate that these enzymes are involved in the adaptation of the fungus in its environment. Indeed, the ligands identified during this work suggest that the "ligandin" properties of TvGSTOs play a role in detoxifying wood degradation products
Sylvestre-Gonon, Elodie. "Caractérisation biochimique et structurale de quelques glutathion transférases de la classe Tau d'arabette (Arabidopsis thaliana) et de peuplier (Populus trichocarpa)". Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0253.
Texto completo da fonteGlutathione transferases (GSTs) constitute a ubiquitous multigene superfamily of enzymes involved in xenobiotic detoxification and secondary metabolism. Canonical GSTs consist of an N-terminal thioredoxin domain and a α-helical C-terminal domain. In terrestrial plants, GSTs can be grouped in 14 classes but also according to the conserved residue found in their catalytic site either cysteine (Cys-GSTs) or serine (Ser-GSTs) GSTs. Ser-GSTs exhibit reduction of peroxides and/or glutathione (GSH) conjugation activities while Cys-GSTs rather exhibit deglutathionylation and dehydroascorbate reductase activities. Some of them also appear to have non-catalytic ligandin properties for the transport or storage of various molecules. The plant-specific Tau GST (GSTU) class is usually the most expanded one. The GSTUs are often over-expressed during biotic and abiotic stresses contributing notably to herbicide detoxification. However, the physiological role of most GSTUs is still poorly documented in planta. By combining phylogenetic, biochemical and structural approaches, this work led to the characterisation of nine GSTUs from Arabidopsis thaliana (AtGSTUs) and six GSTUs from Populus trichocarpa (PtGSTUs). Phylogenetic analysis of the Ser-GSTs present in photosynthetic organisms revealed that the expansion of GSTUs occurred concomitantly with the appearance of vasculature in plants, although some mosses and bryophytes possess GSTUs. Within an organism, GSTUs can be classified into distinct groups according to their catalytic motif. Enzymatic tests using recombinant proteins showed that almost all studied GSTUs exhibit GSH conjugation and peroxide reduction activities against different model substrates (CDNB, isothiocyanate derivatives, hydroperoxides). The three-dimensional structures of two GSTUs have been resolved and these adopt the classical canonical GST fold with some notable difference between them. The biochemical and structural analyses of these AtGSTUs and PtGSTUs further showed that some of them bind bacterial porphyrins while others bind polyphenolic compounds. Among the enzyme-ligand complexes identified, the structure of a bacalein-GSTU has been solved. The use of metabolites enriched samples extracted from A. thaliana and P. trichocarpa is the next step to decipher the role of GSTUs in planta
El, khoury Takla. "Recherche des substrats et des activateurs d'une nouvelle famille de protéine kinase bactérienne". Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV003.
Texto completo da fonteProtein kinases are responsible of protein phosphorylation, a post-translational modification and a very effective and almost instantaneous control of a multitude of cellular processes. They are involved in the regulation of metabolic pathways in living organisms enabling their adaptation to environmental changes. In prokaryotes, the existence of serine/threonine and tyrosine kinases was, for a long time, a subject of controversy. However, over the past two decades, many studies have shown that these types of phosphorylation (Ser/Thr/Tyr) do exist in bacteria and are involved in the regulation of a wide variety of biological processes. In addition to protein kinases related to eukaryotic enzymes, bacteria also have some specific protein kinases having no structural resemblance to their eukaryotic homologues which, if essential, made them a possible target for new antimicrobial agents. YdiB is a novel bacterial protein kinase from Bacillus subtilis. In situ localisation of YdiB has been studied by immunofluorescence which reveals its presence near the plasma membrane. The interaction of YdiB with the membrane phospholipids was assessed by flotation assay and surface plasmon resonance demonstrating the presence of a stable and strong interaction between the kinase and two phospholipids: phosphatidylserine and phosphatidylethanolamine. In addition, the affinity constant (KD) between YdiB and phosphatidylserine was found to be equal to 13.3 x 10-9 M. Moreover, these two phospholipids or just their charged headgroups were able to significantly induce the autophosphorylation of YdiB.On the other hand, the role of YdiB in the bacterial growth especially under oxidative stress was also studied in the wild-type strain and in ∆ydiB mutant. Under oxidative stress conditions, the deleted strain was unable to survive whereas a conditional complementation of ∆ydiB mutant was able to restore a normal growth profile for the bacterium. This reveals the important role played by YdiB in the bacterial resistance to oxidative stress. In addition, protein involved in the resistance to oxidative stress like Superoxide dismutase F (SodF) and superoxide dismutase A (Sod A) were tested as potential substrates for YdiB. Doing the trans-phosphorylation assay, we were able to prove that Sod B could be a potential substrate for YdiB thus explaining its involvement in the resistance to oxidative stress in Bacillus subtilis
Maitro, Guillaume. "Etude de dérivés soufrés en tant que substrats ou ligands en catalyse au palladium". Paris 6, 2007. http://www.theses.fr/2007PA066041.
Texto completo da fonteDagher, Rania Haiech Jacques Pigault Claire. "Recherche de petites molécules bioactives sur la calmoduline outils de recherche pour analyser son rôle dans le signal calcique /". Strasbourg : Université de Strasbourg, 2009. http://eprints-scd-ulp.u-strasbg.fr:8080/1108/01/DAGHER_Rania_2008.pdf.
Texto completo da fonteLe, Manach Claire. "Recherche de ligands du système tubuline/microtubules par chimie combinatoire dynamique". Paris 11, 2008. http://www.theses.fr/2008PA112340.
Texto completo da fonteThe system tubulin/microtubules plays a key-role during mitosis and disturbing its dynamic equilibrium can prevent cell division and induce apoptosis. Antitubulin agents are divided into two classes: those that bind to microtubules, stabilizing them and preventing their depolymerization, and those that bind to tubulin dimer, preventing the formation of microtubules. Most of the known antitubulin agents are characterized by a very complex structure, and therefore are relatively hard to synthesize. We planned to use dynamic combinatorial chemistry combined with the reversible formation of imines in water to identify new potential antitubulin agents. This approach is based on the reversible connection between different building blocks to form a chemical library under thermodynamic equilibrium. In the presence of a target, the distribution of the library may be altered, with an amplification for the best binders, which can be detected by an adequate analytical method after fixation of the library’s distribution. We have demonstrated that dynamic combinatorial chemistry is applicable to the dynamic macromolecular system tubulin/microtubules. Using adequate conditions, we have shown that it is possible to target either the tubulin dimer or microtubules. Then we have designed and synthesized two types of scaffolds in order to use them in dynamic libraries. Among the numerous dynamic libraries we prepared some amplifications were identified. Analogues of amplified imines were synthesized and tested on tubulin. Therefore we were able to identify a new class of microtubules ligands and to show that the orientation of two aromatic moieties plays a key role for the type of activity
Dillard, Pierre. "Impact de la présentation des ligands sur la biophysique de l’adhésion des lymphocytes T". Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4085/document.
Texto completo da fonteT- cells play a central role in cell mediated adaptive immune response. They are a class of lymphocytes that carry distinctive receptors - the TCRs (T cell receptor), which are responsible for specific recognition of foreign peptides in the body. Molecular interactions between the TCR complex and its ligand is followed by cell adhesion and spreading accompanied by dramatic changes at molecular and cellular scale. In this thesis we focus on the events that immediately follow recognition. I report a systematic study of the spreading dynamics and morphology (in terms of adhesion area and actin organization) of T lymphocytes on substrates with mobile or immobilized anti-CD3 (a ligand targeting the TCR complex). The spreading behaviour is seen to be dramatically different on the two types of substrates. Interestingly, on blocking myosin-II or by inclusion of ICAM (ligand of LFA1 integrins) on the substrate, these differences tend to disappear. We propose a model, partially inspired by earlier models of neuronal growth cones and filopodia, that links the dynamics of the leading edge of the spreading T cell to the friction generated at the surface by dragging or pinning of the ligands. I also report studies on T cells interacting with substrates decorated with nano-scale islands of anti-CD3 in a sea of repulsive PEG or a supported lipid bilayer. Dramatic differences in adhesion, organization of actin, and receptor distribution are observed on different geometries. I report advances in multi channel RICM towards the reconstruction of not only the topography of the proximal membrane of the T cell with high level of confidence but also the distal surface of lamellipodia
Capon, Jean-François. "Réactivité de substrats insaturés (alcynes, enynes, ions carbenium, allenylidenes) coordinés à des entités binucléaires du molybdène". Brest, 1995. http://www.theses.fr/1995BRES2002.
Texto completo da fonteVillalobos, Oliver Susana Patricia. "Approches expérimentales et théoriques du comportement dynamique de cycles de substrats binaires". Compiègne, 1990. http://www.theses.fr/1990COMPD301.
Texto completo da fonteLivros sobre o assunto "Recherche de ligands/substrats"
1961-, Keen Mary, ed. Receptor binding techniques. Totowa, N.J: Humana Press, 1999.
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