Literatura científica selecionada sobre o tema "Planar Cellular Polarity (PCP)"
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Artigos de revistas sobre o assunto "Planar Cellular Polarity (PCP)"
Devenport, Danelle. "The cell biology of planar cell polarity". Journal of Cell Biology 207, n.º 2 (27 de outubro de 2014): 171–79. http://dx.doi.org/10.1083/jcb.201408039.
Texto completo da fonteAxelrod, Jeffrey D., e Helen McNeill. "Coupling Planar Cell Polarity Signaling to Morphogenesis". Scientific World JOURNAL 2 (2002): 434–54. http://dx.doi.org/10.1100/tsw.2002.105.
Texto completo da fonteMlodzik, Marek. "Planar cell polarity: moving from single cells to tissue-scale biology". Development 147, n.º 24 (15 de dezembro de 2020): dev186346. http://dx.doi.org/10.1242/dev.186346.
Texto completo da fonteTower-Gilchrist, Cristy, Stephanie A. Zlatic, Dehong Yu, Qing Chang, Hao Wu, Xi Lin, Victor Faundez e Ping Chen. "Adaptor protein-3 complex is required for Vangl2 trafficking and planar cell polarity of the inner ear". Molecular Biology of the Cell 30, n.º 18 (15 de agosto de 2019): 2422–34. http://dx.doi.org/10.1091/mbc.e16-08-0592.
Texto completo da fontePadmanabhan, Krishnanand, Hanna Grobe, Jonathan Cohen, Arad Soffer, Adnan Mahly, Orit Adir, Ronen Zaidel-Bar e Chen Luxenburg. "Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity". Development 147, n.º 23 (1 de dezembro de 2020): dev193425. http://dx.doi.org/10.1242/dev.193425.
Texto completo da fonteKim, Su Kyoung, Asako Shindo, Tae Joo Park, Edwin C. Oh, Srimoyee Ghosh, Ryan S. Gray, Richard A. Lewis et al. "Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis". Science 329, n.º 5997 (29 de julho de 2010): 1337–40. http://dx.doi.org/10.1126/science.1191184.
Texto completo da fonteBabayeva, Sima, Yulia Zilber e Elena Torban. "Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes". American Journal of Physiology-Renal Physiology 300, n.º 2 (fevereiro de 2011): F549—F560. http://dx.doi.org/10.1152/ajprenal.00566.2009.
Texto completo da fonteZilber, Yulia, Sima Babayeva, Jung Hwa Seo, Jia Jia Liu, Steven Mootin e Elena Torban. "The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium". Molecular Biology of the Cell 24, n.º 5 (março de 2013): 555–65. http://dx.doi.org/10.1091/mbc.e12-06-0437.
Texto completo da fonteGault, William J., Patricio Olguin, Ursula Weber e Marek Mlodzik. "Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking". Journal of Cell Biology 196, n.º 5 (5 de março de 2012): 605–21. http://dx.doi.org/10.1083/jcb.201107137.
Texto completo da fonteGajos-Michniewicz, Anna, e Malgorzata Czyz. "WNT Signaling in Melanoma". International Journal of Molecular Sciences 21, n.º 14 (9 de julho de 2020): 4852. http://dx.doi.org/10.3390/ijms21144852.
Texto completo da fonteTeses / dissertações sobre o assunto "Planar Cellular Polarity (PCP)"
Barrott, Jared James. "Wnt5a Signaling Independently of the Planar Cell Polarity Pathway Resulting in Convergent Extension and Neural Tube Closure During Vertebrate Development". Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2612.pdf.
Texto completo da fonteBoëx, Myriam. "Implication d’une nouvelle voie de signalisation médiée par le complexe MuSK/Vangl2 dans la connectivité neuromusculaire". Electronic Thesis or Diss., Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2020SORUS258.pdf.
Texto completo da fonteThe neuromuscular junction (JNM) is a peripheral synapse formed by the anatomic and functional contact between a motor neuron and a striated skeletal muscle fiber. NMJ development requires a dynamic communication between motor axons and their muscle targets through several reciprocal signaling. Among the limited number of secreted factors that orchestrate this trans-synaptic coordination, the Wnts diffusible cues have emerged as critical signals for synaptic differentiation, yet how Wnt signaling drives NMJ formation and maintenance remain poorly understood and controversial in mammals. In this context, the aims of my PhD project were 1) to validate the functional role of Wnt-MuSK interaction in vivo and 2) to study the Wnt Planar Cell Polarity (PCP) pathway during NMJ assembly and maintenance in mammals. Interestingly, our team showed that Van Gogh-like protein 2 (Vangl2), a core PCP component, is accumulated at developing NMJ, at both pre- and postsynaptic sites. Moreover, Vangl2 interacts with a subset of Wnt morphogens that are secreted at the NMJ suggesting that a Wnt/Vangl2-PCP signaling is involved in NMJ development. By using a set of mutant mice along with a large panel of cell biological and biochemical assays, I found that muscle Vangl2 is critical for NMJ assembly and maintenance, by controlling the level of MuSK signaling activity. Collectively, my results uncover a new Wnt/PCP signaling in the muscle, relying on Vangl2/MuSK interaction that shapes neuromuscular connectivity by regulating postsynaptic assembly and integrity
Watson, Julia Alice. "Investigating the role of Wnt/Planar cell polarity (PCP) in Neuromesodermal Progenitors (NMPs)". Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31193.
Texto completo da fonteGiese, Arnaud. "Régulation de la protéine centrale de la polarité planaire cellulaire Vangl2 dans l’organe de Corti". Thesis, Bordeaux 2, 2010. http://www.theses.fr/2010BOR21761/document.
Texto completo da fonteSeveral epithelia exhibit a second polarity perpendicular to the apico-basal axis, called planar polarity and that governs the orientation of structures such as stereocilia and hear. Our laboratory studies planar polarity, using mammalian cochlear sensory epithelium and we focus our studies on Vangl2, that we identified as the first mammalian planar polarity gene. Vangl2 encodes a four-transmembrane protein that contains a PDZ binding domain in its C-terminus tail. Vangl2 is asymmetrically located at the junction between mechanosensory hair cells and supporting cells, and this asymmetry appears important for planar cell polarity. I have shown in my thesis, using STED microscopy, that Vangl2 asymmetry is mainly due to an accumulation of Vangl2 to the distal side of supporting cells. I sought to dissect the molecular role of Vangl2 by analysing its trafficking within the cochlear epithelium. Deletion analysis shows that the last 12 amino acids, unlike its N-terminus tail are essential for Vangl2 endoplasmic reticulum sorting, its plasma membrane targeting and its function. Conditional mutant mice analysis show that Scrib1, which we have previously shown, interacts with Vangl2 through the PDZ binding domain of its C-terminal tail, is not the protein mediating this asymmetry. My work also highlight that GIPC1 had a role in the regulation of PCP and maintaining the integrity of hair bundles of sensory cells, and that the complex GIPC1/Myosin VI could regulate Vangl2 asymmetry in the organ of Corti
Martinez, Sébastien. "Rôle de la protéine tyrosine kinase 7 dans le cancer colorectal et la polarité planaire cellulaire". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4019.
Texto completo da fonteThe non-canonical WNT/planar cell polarity (WNT/PCP) pathway plays important roles in morphogenetic processes in vertebrates. Among WNT/PCP components, protein tyrosine kinase 7 (PTK7) is a tyrosine kinase receptor with poorly defined functions lacking catalytic activity. We show that PTK7 associates with receptor tyrosine kinase-like orphan receptor 2 (ROR2) to form a heterodimeric complex in mammalian cells and physically and functionally interact with the non-canonical WNT5A ligand, leading to JNK activation and cell movements. In the Xenopus embryo, Ptk7 functionally interacts with Ror2 to regulate protocadherin papc expression and morphogenesis. Furthermore, we show that Ptk7 is required for papc activation induced by Wnt5a and that Wnt5a stimulates the release of the Ptk7 intracellular domain, which can translocate into the nucleus and activate papc expression. Moreover, using a Tissue MicroArray produced from CRC patients we correlated PTK7 expression with pathological features and patient outcome. PTK7 was significantly up-regulated in CRC tissue, and its overexpression was found in 34% of patients. In CRC cell lines, shRNA PTK7 reduced migration, but did not affect cell proliferation and resistance to drugs. In a xenograft mouse model, downregulation of PTK7 led to reduced tumor growth, whereas its overexpression in PTK7-negative cancer cells led to increased metastatic events. This work reveals novel molecular mechanisms of action of PTK7 in non-canonical WNT/PCP signaling that may promote cell and tissue movements and define PTK7 expression as a potential prognostic biomarker and a novel therapeutic target in CRC
Godfrey, Grayland W. II. "Characterizing the Role of Key Planar Cell Polarity Pathway Components in Axon Guidance". VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4841.
Texto completo da fonteTanner, Raymond. "A Role for the Planar Cell Polarity Pathway in Neuronal Positioning Along the AP Axis of C. elegans". Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31521.
Texto completo da fonteSchäfer, Simon Thomas [Verfasser]. "ATP6AP2 is critically involved in adult hippocampal neurogenesis and reveals stage-specific functions for Wnt/ß-Catenin and Wnt/Planar Cell Polarity (PCP) signaling / Simon Thomas Schäfer". Greifswald : Universitätsbibliothek Greifswald, 2015. http://d-nb.info/1069389331/34.
Texto completo da fonteAllen, John C. "FGF4 Induced Wnt5a Gradient in the Limb Bud Mediates Mesenchymal Cell Directed Migration and Division". BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4309.
Texto completo da fonteEl-Hassan, Abdul-Rahman. "Caractérisation moléculaire et fonctionnelle d'un nouvel allèle du gène de la polarité cellulaire planaire (PCP) Vangl2". Thèse, 2017. http://hdl.handle.net/1866/20536.
Texto completo da fonteLivros sobre o assunto "Planar Cellular Polarity (PCP)"
Zaffran, Stéphane. Cardiac growth II: Cardiomyocyte polarization. Editado por José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso e Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0010.
Texto completo da fonteKühn, Wolfgang, e Gerd Walz. The molecular basis of ciliopathies and cyst formation. Editado por Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0303.
Texto completo da fonteCapítulos de livros sobre o assunto "Planar Cellular Polarity (PCP)"
Moreira, Sofia, Jaime A. Espina, Joana E. Saraiva e Elias H. Barriga. "A Toolbox to Study Tissue Mechanics In Vivo and Ex Vivo". In Methods in Molecular Biology, 495–515. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2035-9_29.
Texto completo da fonte"Planar Cell Polarity (PCP)". In Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1502. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_12937.
Texto completo da fonteGao, Bo. "Wnt Regulation of Planar Cell Polarity (PCP)". In Planar Cell Polarity During Development, 263–95. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-12-394592-1.00008-9.
Texto completo da fonteBoutin, Camille, André M. Goffinet e Fadel Tissir. "Celsr1–3 Cadherins in PCP and Brain Development". In Planar Cell Polarity During Development, 161–83. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-12-394592-1.00010-7.
Texto completo da fonteTrabalhos de conferências sobre o assunto "Planar Cellular Polarity (PCP)"
Asad, Mohammad, Meng Kang Wong, Tuan Zea Tan, David Virshup, Jean Paul Thiery e Ruby Yun-Ju Huang. "Abstract A30: Frizzled-7 (FZD7)-mediated non-canonical Wnt-Planar Cell Polarity (PCP) signalling pathway as a novel molecular driver for the C5/Proliferative/Stem-A molecular subtype of ovarian cancer." In Abstracts: AACR Special Conference: Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; October 17-20, 2015; Orlando, FL. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3265.ovca15-a30.
Texto completo da fonte