Literatura científica selecionada sobre o tema "PiRNA clusters"
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Artigos de revistas sobre o assunto "PiRNA clusters"
Komarov, Pavel A., Olesya Sokolova, Natalia Akulenko, Emilie Brasset, Silke Jensen e Alla Kalmykova. "Epigenetic Requirements for Triggering Heterochromatinization and Piwi-Interacting RNA Production from Transgenes in the Drosophila Germline". Cells 9, n.º 4 (10 de abril de 2020): 922. http://dx.doi.org/10.3390/cells9040922.
Texto completo da fonteRadion, Elizaveta, Olesya Sokolova, Sergei Ryazansky, Pavel Komarov, Yuri Abramov e Alla Kalmykova. "The Integrity of piRNA Clusters is Abolished by Insulators in the Drosophila Germline". Genes 10, n.º 3 (11 de março de 2019): 209. http://dx.doi.org/10.3390/genes10030209.
Texto completo da fonteChen, Peiwei, Yicheng Luo e Alexei A. Aravin. "RDC complex executes a dynamic piRNA program during Drosophila spermatogenesis to safeguard male fertility". PLOS Genetics 17, n.º 9 (2 de setembro de 2021): e1009591. http://dx.doi.org/10.1371/journal.pgen.1009591.
Texto completo da fonteAssis, Raquel, e Alexey S. Kondrashov. "Rapid repetitive element-mediated expansion of piRNA clusters in mammalian evolution". Proceedings of the National Academy of Sciences 106, n.º 17 (8 de abril de 2009): 7079–82. http://dx.doi.org/10.1073/pnas.0900523106.
Texto completo da fonteStory, Benjamin, Xing Ma, Kazue Ishihara, Hua Li, Kathryn Hall, Allison Peak, Perera Anoja et al. "Defining the expression of piRNA and transposable elements in Drosophila ovarian germline stem cells and somatic support cells". Life Science Alliance 2, n.º 5 (outubro de 2019): e201800211. http://dx.doi.org/10.26508/lsa.201800211.
Texto completo da fonteIyer, Shantanu S., Yidan Sun, Janine Seyfferth, Vinitha Manjunath, Maria Samata, Anastasios Alexiadis, Tanvi Kulkarni et al. "The NSL complex is required for piRNA production from telomeric clusters". Life Science Alliance 6, n.º 9 (30 de junho de 2023): e202302194. http://dx.doi.org/10.26508/lsa.202302194.
Texto completo da fonteWang, Sheng, Xiaohua Lu, Ding Qiu e Yang Yu. "To export, or not to export: how nuclear export factor variants resolve Piwi's dilemma". Biochemical Society Transactions 49, n.º 5 (13 de outubro de 2021): 2073–79. http://dx.doi.org/10.1042/bst20201171.
Texto completo da fonteWang, Jiajia, Yirong Shi, Honghong Zhou, Peng Zhang, Tingrui Song, Zhiye Ying, Haopeng Yu et al. "piRBase: integrating piRNA annotation in all aspects". Nucleic Acids Research 50, n.º D1 (6 de dezembro de 2021): D265—D272. http://dx.doi.org/10.1093/nar/gkab1012.
Texto completo da fonteKofler, Robert. "piRNA Clusters Need a Minimum Size to Control Transposable Element Invasions". Genome Biology and Evolution 12, n.º 5 (27 de março de 2020): 736–49. http://dx.doi.org/10.1093/gbe/evaa064.
Texto completo da fonteHuang, Xinya, Peng Cheng, Chenchun Weng, Zongxiu Xu, Chenming Zeng, Zheng Xu, Xiangyang Chen, Chengming Zhu, Shouhong Guang e Xuezhu Feng. "A chromodomain protein mediates heterochromatin-directed piRNA expression". Proceedings of the National Academy of Sciences 118, n.º 27 (29 de junho de 2021): e2103723118. http://dx.doi.org/10.1073/pnas.2103723118.
Texto completo da fonteTeses / dissertações sobre o assunto "PiRNA clusters"
Mouniée, Nolwenn. "Etude de la biologie des clusters de piRNAs chez Drosophila melanogaster en utilisant comme modèle le locus flamenco". Thesis, Université Clermont Auvergne (2017-2020), 2019. http://www.theses.fr/2019CLFAC029/document.
Texto completo da fonteTransposable elements (TEs) are defined such as mobile DNA sequences found in genomes ofall species where they were searched. As evolutionary drivers, these mobile elements, presentin many copies in genomes, have played a major role in the genome dynamics by generatingmutations and chromosomal rearrangements. Nevertheless, being major genome constituents,they must be finely regulated in order to preserve the genomic integrity, and thus, to maintainthe balance between variability and stability of genomes. In order to protect the geneticinformation of the host transmitted to the offspring, the gonadal TE regulation is carried outby the piRNAs pathway, an interfering RNA pathway conserved in animals. Although this isrelatively well described in Drosophila and in mouse, some steps of piRNA pathway are stillmisunderstood. During my thesis, I explored various aspects of piRNA cluster biology, usingthe flamenco locus as a model. This piRNA cluster is the main piRNA producer in thefollicular cells of Drosophila melanogaster ovaries. First, I analyzed the spatio-temporalwindows of flamenco piRNA cluster expression throughout the Drosophila development,from embryo to adulthood. Then, I searched, in vivo, the flamenco transcript sequence thatwould be sufficient to induce the addressing of a chimeric transcript to the piRNA processingpathway. I also explored the impact of some factors on the management of artificialtranscripts by piRNAs. Finally, I was interested in the gene regulation that flamenco-derivedpiRNAs could make in Drosophila ovaries by searching, through bioinformatics andmolecular biology approaches, the potentially recognized genes, and therefore, regulated byflamenco piRNAs. All of these in vivo research axes will advance in the understanding of thebiology of piRNA clusters as well as the molecular mechanisms involved in the piRNAbiogenesis in Drosophila
Chang, Timothy H. "Maelstrom Represses Canonical RNA Polymerase II Transcription in Drosophila Dual-Strand piRNA Clusters". eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/978.
Texto completo da fonteLe, Thomas Adrien. "Piwi function and piRNA cluster regulation : Drosophila melanogaster". Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066688/document.
Texto completo da fontePiRNAs are a diverse population of small RNA found in the animal germline to silence mobile genetic elements: loaded into Piwi proteins, they guide homology-dependent cleavage of active transposon mRNAs. In Drosophila, three Piwi proteins are expressed, from which two, AUB and AGO3, are known to destroy transposon transcripts in the cytoplasm. The third one, Piwi itself, is nuclear and the molecular mechanism of its function remains unknown. The main sources of piRNAs are discrete genomic loci called piRNA clusters, however it is not known what differentiate them from non-piRNA producing loci. During my PhD, I focused my work on two central questions:1) What is the role of Piwi in the nucleus? We showed that Piwi is responsible for transcriptional silencing by mediating installment of repressive marks, especially H3K9me3, over active transposons copies in a piRNA dependent manner.2) How are piRNA clusters defined, and what regulates their expression? Analyzing what features differentiate a piRNA producing loci from any non-producing loci in the genome, we were able to single out some specific characteristics: . We showed that maternally inherited piRNAs are responsible to define germline clusters at the next generation through two mechanisms: in the nucleus, by deposition of H3K9me3 onto complementary genomic sequence, and, in the cytoplasm, by initiating the ping-pong cycle using cluster transcripts as substrates, leading to their processing into mature piRNAs.. We found that cluster promoters are essential to mediate full cluster transcription, which is allowed thanks to a very specific chromatin signature necessary to ensure piRNA production
Capítulos de livros sobre o assunto "PiRNA clusters"
Olovnikov, Ivan, Adrien Le Thomas e Alexei A. Aravin. "A Framework for piRNA Cluster Manipulation". In Methods in Molecular Biology, 47–58. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-694-8_5.
Texto completo da fonteTrabalhos de conferências sobre o assunto "PiRNA clusters"
Dennis, Cynthia. "Regulatory properties of piRNA clusters from Drosophila melanogaster". In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.89533.
Texto completo da fonte"The role of the rhino gene in the transcriptional regulation of different piRNA clusters". In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-402.
Texto completo da fonte