Artigos de revistas: "Pediatric cardiography"

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McGrath, Jennifer J., e William H. O'Brien. "Pediatric impedance cardiography: Temporal stability and intertask consistency". Psychophysiology 38, n.º 3 (maio de 2001): 479–84. http://dx.doi.org/10.1111/1469-8986.3830479.

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Miles, D. S., R. W. Gotshall e W. R. Sexson. "Evaluation of impedance cardiography in the canine pup". Journal of Applied Physiology 60, n.º 1 (1 de janeiro de 1986): 260–65. http://dx.doi.org/10.1152/jappl.1986.60.1.260.

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This study evaluated the use of the noninvasive technique of impedance cardiography to assess central hemodynamics in an animal model similar in size to the neonate. Seven canine pups 5–6 wk of age, with an average weight of 2.2 kg, were studied. To alter cardiac output (Q), the pups were given 12 and 8% O2 to breathe, which produced an arterial PO2 of 30 and 21 Torr, respectively. Q was obtained simultaneously by impedance and thermal dilution under both normoxic and hypoxic conditions. The average Q measured by impedance and thermal dilution were within 10% agreement and moderately correlated (r = 0.76). Impedance Q and stroke volume (SV) averaged 201 ml X min-1 X kg-1 and 2.8 ml, respectively. Thermal dilution Q and SV averaged 212 ml X min-1 X kg-1 and 2.9 ml, respectively. Individual responses to the hyoxemia were variable, but the impedance technique appeared to measure these individual responses as well as the thermal-dilution technique. These findings demonstrate that impedance cardiography may be suitable to assess either the absolute or relative changes in central hemodynamics. The use of this technique in critical care neonatal and pediatric medicine seems justified.

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Das, B. B., S. Doyle, L. Baker, C. Smith e M. Recto. "506: Comparison of Impedance Cardiography to Thermodilution Cardiac Output Determination in Pediatric Heart Transplant Patients". Journal of Heart and Lung Transplantation 27, n.º 2 (fevereiro de 2008): S242. http://dx.doi.org/10.1016/j.healun.2007.11.520.

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Kalinina, M., e Y. B. Fedorova. "P01-302-Psychosomatics in children with cardiopathies". European Psychiatry 26, S2 (março de 2011): 304. http://dx.doi.org/10.1016/s0924-9338(11)72013-2.

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IntroductionIt is known the prevalence of mental pathology among patients with connective tissue disorders and functional cardiopathies essentially exceeds their prevalence in the general pediatric population.ObjectivesTo study the clinic features of psychosomatic disorders in childhood in the cardiology clinic 26 children of 5–12 years with functional cardiopathies have been investigated.MethodsChildren were surveyed by psychopathological, neurological, pediatric methods. The clinical and biochemical blood tests, urine tests, ECG, ultrasonic cardiography, sono-encephalography, EEG were investigated.ResultsIn a mental condition of children the neurotic frustration which plot was defined by cardiac complaints acted. They aroused in 52, 3% against schizotipical disorders, in 47, 7% accentuations of psychasthenic and dissociative type. In 15, 3% cases were detected transient psychotic episodes with fragmented polymorphic psychopathology. More than half of 26 children, had family history of social factors, were brought under partial maternal deprivation. Detect violations of lateralization, visual perception and information processing with weakness predominantly right-brain functions were revealed. In 92, 3% identified functional abnormalities of the structure of the heart (more trabeculae, patent foramen ovale) without hemodynamic instability.ConclusionsThus, the violations constitute one of the variants of psychosomatic disorders in children masquerading cardiac pathology. Further studies will clarify the more subtle mechanisms of marked pathology, but now there is no doubt that in creating it plays the role of a range of factors.

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Hussien, RaniaM, HebaAA Labib e YasserA Salem. "Monitoring the correlation between passive leg-raising maneuver and fluid challenge in pediatric cardiac surgery patients using impedance cardiography". Egyptian Journal of Cardiothoracic Anesthesia 10, n.º 1 (2016): 17. http://dx.doi.org/10.4103/1687-9090.183222.

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Taylor, Katherine, Cedric Manlhiot, Brian McCrindle, Lars Grosse-Wortmann e Helen Holtby. "Poor Accuracy of Noninvasive Cardiac Output Monitoring Using Bioimpedance Cardiography [PhysioFlow®] Compared to Magnetic Resonance Imaging in Pediatric Patients". Survey of Anesthesiology 56, n.º 6 (dezembro de 2012): 303. http://dx.doi.org/10.1097/01.sa.0000422215.59743.dd.

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Taylor, Katherine, Cedric Manlhiot, Brian McCrindle, Lars Grosse-Wortmann e Helen Holtby. "Poor Accuracy of Noninvasive Cardiac Output Monitoring Using Bioimpedance Cardiography [PhysioFlow®] Compared to Magnetic Resonance Imaging in Pediatric Patients". Anesthesia & Analgesia 114, n.º 4 (abril de 2012): 771–75. http://dx.doi.org/10.1213/ane.0b013e318246c32c.

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Sukalo, A. V., e I. A. Kazyra. "Characteristics of the course of nephritis associated with Iga-vasculitis Henoch-Schoenlein in children". Nephrology (Saint-Petersburg) 24, n.º 3 (23 de abril de 2020): 64–71. http://dx.doi.org/10.36485/1561-6274-2020-24-3-64-71.

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INTRODUCTION. Among systemic vasopathies in children, IgA vasculitis Henoch Schoenlein (HS) is the most common, according to various authors, kidney damage is noted in 25-80 % and usually determines the prognosis of the disease.THE AIM of the study was to analyze clinical, laboratory, immunological, morphological characteristics, features of the course and treatment of nephritis associated with IgA vasculitis HS in children, as well as factors affecting the prognosis.PATIENTS AND METHODS. The study included 31 patients with morphologically verified nephritis due to IgA vasculitis HS (18 – boys, 13 – girls) aged 3 to 17 years, who were monitored at the Nephrology Department of the "2nd Children's City Clinical Hospital" of the National Center for Pediatric Nephrology and Renal Replacement therapy in Minsk from 2010 to 2019 yrs.The following parameters were analyzed: the clinical variant of kidney damage, laboratory tests (including the study of BAFF, RANTES lymphocyte activation molecules, pro-inflammatory IL1β, caspase1, TNFα, growth factors VEGF, TGF), 24 hours monitoring and office blood pressure measurements, ECHO cardiography with indicescalculation, ultrasound of the carotid arteries with the thickness of intima-media complex, morphological changes in the renal tissue, as well as treatment regimens.RESULTS. The contribution of deGal-IgA1, markers of T and B lymphocytes activation, pro-inflammatory and profibrotic molecules in the development of the disease is shown. Arterial hypertension was registered in 42 % of children, signs of heart remodeling according to the calculated indices in 19,3 %. Decrease level of adiponectin, vitamin D, leptin, increase concentration of obestatin, Pro-BNP, hs-CRP, and TSAT indicator classify patients with nephritis due to IgA vasculitis HS at moderate risk for the developmentof cardio-vascular disorders, which suggests the need for timely correction.CONCLUSION. In most cases, nephritis with IgA vasculitis HS has a benign course with rare relapses and progression to the end stage of chronic kidney disease (6,5 %).

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Raaijmaakers, Brigitte, Aagje Nijveld, Anton van Oort, Ronald Tanke e Otto Daniëls. "Difficulties generated by the small, persistently patent, arterial duct". Cardiology in the Young 9, n.º 4 (julho de 1999): 392–95. http://dx.doi.org/10.1017/s1047951100005199.

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AbstractOver recent years, echo-Doppler cardiography has shown that a small, sometimes silent, arterial duct exists in more patients than previously recognized. To know the incidence of an arterial duct subsequent to therapy, we studied retrospectively our patients undergoing open-heart surgery and surgical or catheter closure. Three groups of patients were studied: those with patency of the duct subsequent to open heart surgery without any sign of patency before or during surgery, those with persistent duct after surgical ligation and those with persistent patency after attempted catheter occlusion with the Rashkind device. In the first group (of 431 children) four (0.9%) had persistence of this duct, of which three were silent. In the second group, patency persisted in four of 100 patients (4%), three being silent. In the last group there were five persisting shunts, three producing no murmur, in 30 patients (17%). We compared our results with those reported in the literature and conclude that echo-Doppler cardiography is needed to detect persistent shunting across a duct after therapy, since most of the residual ducts in this study were silent. This means that clinical findings alone cannot be relied upon, and careful echo-Doppler cardiography is essential. Also, the process of closure of a persistent duct by surgical ligation or transcatheter intervention is no guarantee of success. The risk of infective endocarditis is important in such persistent ducts and, at present, it is unknown either for a small, silent duct or in a persistent duct that remains open after attempted transcatheter closure, but now is in association with a foreign body.

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Burlingame, J., P. Ohana, M. Aaronoff e T. Seto. "Noninvasive cardiac monitoring in pregnancy: impedance cardiography versus echocardiography". Journal of Perinatology 33, n.º 9 (16 de maio de 2013): 675–80. http://dx.doi.org/10.1038/jp.2013.35.

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Wilken, Meike, Jun Oh, Hans O. Pinnschmidt, Dominique Singer e Martin E. Blohm. "Effect of hemodialysis on impedance cardiography (electrical velocimetry) parameters in children". Pediatric Nephrology 35, n.º 4 (14 de dezembro de 2019): 669–76. http://dx.doi.org/10.1007/s00467-019-04409-1.

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Morris, Rachael, Imran Sunesara, Marie Darby, Sarah Novotny, Luissa Kiprono, Leody Bautista, Sandip Sawardecker, James Bofill, Belinda Anderson e James N. Martin. "Impedance cardiography assessed treatment of acute severe pregnancy hypertension: a randomized trial". Journal of Maternal-Fetal & Neonatal Medicine 29, n.º 2 (30 de dezembro de 2014): 171–76. http://dx.doi.org/10.3109/14767058.2014.995081.

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Chaffin, David, e Denise Webb. "Outcomes of Pregnancies at Risk for Hypertensive Complications Managed Using Impedance Cardiography". American Journal of Perinatology 26, n.º 10 (18 de maio de 2009): 717–21. http://dx.doi.org/10.1055/s-0029-1223283.

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Kardos, Attila, Gabor Vereczkey, Laszlo Pirot, Peter Nyirady e Robert Mekler. "Use of impedance cardiography to monitor haemodynamic changes during laparoscopy in children". Pediatric Anesthesia 11, n.º 2 (março de 2001): 175–79. http://dx.doi.org/10.1046/j.1460-9592.2001.00639.x.

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NAGASHIMA, MASAMI. "Fundamental and application of cardiographic science. Pediatrics. Application of electrocardiogram to physical examination in schools." Japanese Journal of Electrocardiology 19, n.º 2 (1999): 179–85. http://dx.doi.org/10.5105/jse.19.179.

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Lindblade, C., M. Schamberger, E. Ebenroth e A. Batra. "13 Comparison of Impedance Cardiography to Direct Fick and Echocardiographic Measurement of Cardiac Index in Children." Pediatric Research 58, n.º 4 (outubro de 2005): 818. http://dx.doi.org/10.1203/00006450-200510000-00043.

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TEIEN, D., K. KARP, H. WENDEL, D. G. HUMAN e M. A. NANTON. "Quantification of Left to Right Shunts by Echo Doppler Cardiography in Patients with Ventricular Septal Defects". Acta Paediatrica 80, n.º 3 (março de 1991): 355–60. http://dx.doi.org/10.1111/j.1651-2227.1991.tb11862.x.

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Das, Bibhuti B., Ashok Raj, Michael Recto, Maiying Kong e Salvatore Bertolone. "Utility of Impedance Cardiography for the Detection of Hemodynamic Changes in Stable Patients With Sickle Cell Disease". Journal of Pediatric Hematology / Oncology 34, n.º 5 (julho de 2012): 336–39. http://dx.doi.org/10.1097/mph.0b013e3182580300.

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Ferdousi, Shormin Ara, Ferdousur Rahman Sarker, Nasim Jahan e Nurunnahar Fatema. "Pattern of Congenital Heart Disease in Infants of Diabetic Mother". Bangladesh Journal of Child Health 38, n.º 2 (3 de dezembro de 2014): 79–85. http://dx.doi.org/10.3329/bjch.v38i2.21140.

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Background: The aim of the study was to unveil the prevalence of different types of Congenital Heart Disease (CHD) through echocardiogram and to perceive the utility of Echocardiogram in diagnosis of CHD in Infant of Diabetic Mother (IDM). Methodology: This explorative study was carried out at Combined Military Hospital (CMH) Dhaka, Bangladesh over a period of one year from July 2004 to June 2005. The study was done on 56 neonates of gestational diabetic mother irrespective of their gestational age and birth weight who were delivered at CMH. All the patients were evaluated by echocardiography by an expert pediatric cardiologist of the same institute within 7 days of delivery. Results: Out of 56 IDM 5.2% was normal. The most common Echo-cardiographic finding was patent Foramen Ovale (60.71%). Other different Echocardiographic findings were patent Ductusarteriosusin 31 (55.3%) cases, Hypertrophic Cardiomyopathy in 12 (21.42%) cases and ASD in 6 (10.71%) cases. Some other uncommon findings include Ventricular Septal Defect (VSD), Tricuspid Regurgitation(TR) and Right ventricular hypertrophy(RVH). Conclusion: These findings of CHD of Infant of Diabetic Mother (IDM) could demonstrate that Echocardiogram might be used as an effective tool to diagnose CHD for the IDM. DOI: http://dx.doi.org/10.3329/bjch.v38i2.21140 Bangladesh J Child Health 2014; VOL 38 (2) : 74-78

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Sima, Romina-Marina, Sebastian Findeklee, Ioana-Anca Bădărău, Mircea-Octavian Poenaru, Cristian Scheau e Liana Pleș. "Comparison of maternal third trimester hemodynamics between singleton pregnancy and twin pregnancy". Journal of Perinatal Medicine 49, n.º 5 (11 de fevereiro de 2021): 566–71. http://dx.doi.org/10.1515/jpm-2020-0169.

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Abstract Objectives The impedance cardiography (ICG) technique measures the variation of impedance in the thorax due to the physical contractile activity of the heart. Twin pregnancy is characterized by greater maternal hemodynamic changes than a singleton pregnancy. Methods In a study on 121 pregnant women in the last trimester we performed ICG, evaluating the following hemodynamic parameters: stroke volume, heart rate, cardiac output, ventricular ejection time, left ventricular ejection time, thoracic impedance, and systemic vascular resistance. Results The study included singleton and twin pregnancies. Heart rate values in women with single fetus was lower than in those carrying twins (85 vs. 100 beats/min, p=0.021) as were the stroke volume values (64 vs. 83 mL, p=0.010) and the cardiac output (p<0.0001). Systemic vascular resistance decreased in twin pregnancies compared to singleton pregnancy (p=0.023). Conclusions ICG studies are rare, and the validation of their results is an ongoing process. However, the ICG technique is applicable in the third trimester of pregnancy and can yield important information regarding the hemodynamic profile of singleton and twin pregnancies, revealing maternal heart changes specific to twin pregnancies.

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Gielen, Hanneke, Otto Daniëls e Henk van Lier. "Natural history of congenital pulmonary valvar stenosis: an echo and Doppler cardiographic study". Cardiology in the Young 9, n.º 2 (março de 1999): 129–35. http://dx.doi.org/10.1017/s1047951100008337.

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AbstractDoppler echocardiography allows accurate serial assessment of pulmonary valvar stenosis by measuring the velocity of the jet stream through the pulmonary valve. Between 1979 and 1997, we saw 174 patients with isolated pulmonary valvar stenosis. At admission their ages ranged from 9 days to 22.5 years. We measured the velocity over the pulmonary valve, and the thickness of the anterior wall of the right ventricle, and made a study of their electrocardiograms. We found that rapid increases and decreases occurred in almost every age-group. For patients with a trivial, mild or moderate level of stenosis, severe stenosis developed in 3, 10 and 9%, respectively. In most of the patients, 122 (90%), in whom there was more than one examination, a change in pressure gradient between −12mmHg/year and +3mmHg/year was found. Only 7 patients had an increase of more than 10mmhg per year. In contrast with our patients having aortic stenosis, these with stenosis of the pulmonary valve showed no rapid increase in early childhood. Indeed, in 58% the severity of the stenosis decreased. No correlation was found when comparing the echocardiographic measurements of the thickness of the anterior wall of the right ventricle with the voltages on the electrocardiogram. A significant relation was found however, between an increasing pressure gradient and thickened valvar leaflets (p = 0.017).

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Király, Petèr, Livia Kapusta, Henk van Lier, Anke Otten Hofman e Otto Daniëls. "Natural history of congenital aortic valvar stenosis: an echo and Doppler cardiographic study". Cardiology in the Young 7, n.º 2 (abril de 1997): 188–93. http://dx.doi.org/10.1017/s1047951100009458.

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AbstratThe availability of echo Doppler cardiography enables monitoring of the natural course of congenital aortic valvar stenosis more adequately than before. Between 1986 and 1993, 129 children with such stenosis were examined echocardiographically, 83 of them over a prolonged period with repeated studies of at least one per year. The pressure gradient between the left ventricle and ascending aorta, as well as the left ventricular wall thickness, were measured. When the pressure gradient detected increased to more than 60 mmHg, the patients were treated by balloon valvoplasty or surgical valvotomy. The last examination prior to intervention was taken as the final measurement.We found a significant increase (≥10 mmHg) in the measured pressure gradient in 40 of the 83 patients (48%). The onset of severe stenosis was not observed at a specific age, rather the stenosis was found suddenly to increase in severity at any age. The gradients measured in children younger than 2 years of age, however, increased twice as rapidly as those measured in the older children. A high gradient was not always accompanied by evidence of left ventricular hypertrophy.Based on our findings, we suggest that, since a sudden increase in severity of aortic valvar stenosis might be expected, the pressure gradient should be measured once every 6 months in children younger than 2 years of age and once a year after that age

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Alagarasan, N., M. R. Sahu, M. K. Mohanty, S. S. Sahu e S. Purkait. "Hypertrophic Cardiomyopathy with Massive Cardiomegaly in Indian Young Adult: Autopsy Case Report". Journal of Indian Academy of Forensic Medicine 45, n.º 2 (2023): 181–83. http://dx.doi.org/10.48165/jiafm.2023.45.2.19.

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The sudden death of a bread winning adult in the family is devastating for any family. Even worse is when the adult dies in his young adulthood. Cardiovascular pathologies dominate the causes of sudden deaths in young adults more than the central nervous and respiratory systems. The enlarged heart or cardiomegaly at autopsy is the first indication of such cardiac pathology. Cardiomegaly may result from various pathologies such as hypertension, cardiomyopathies, rheumatic valvular diseases, etc. The resultant increase in the heart's weight due to the cardiac myocytes' adaptive response to meet the demand in the above conditions is known as cardiac hypertrophy. Although multiple reports on cardiomegaly were described from clinical settings based on imaging modalities like X-ray or echo cardiography, the data is lacking from forensic autopsies, especially from India. This is the first case report describing a young adult male of 30 years old who died due to massive cardiomegaly with a heart weight of 878 g from hypertrophic cardiomyopathy.

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Wodey, Eric, Lotfi Senhadji, Jean Yves Bansard, Xavier Beneux, Claude Ecoffey e Fran??ois Carre. "Impedance cardiographic waveforms in children: Involvement in left ventricular ejection time determination during anesthesia". Pediatric Critical Care Medicine 2, n.º 3 (julho de 2001): 250–59. http://dx.doi.org/10.1097/00130478-200107000-00012.

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Satoh, Shoji, Yasuo Yumoto, Yasuyuki Fujita, Naoko Kinukawa e Hitoo Nakano. "Noninvasive measurement of isovolumetric contraction time by Doppler cardiography can be substituted for fetal cardiac contractility: Evaluation of a fetal lamb study". Early Human Development 83, n.º 4 (abril de 2007): 263–67. http://dx.doi.org/10.1016/j.earlhumdev.2006.06.001.

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Hassan, Mohammed O., Deepali Jaju, V. Saroja Voruganti, Riad A. Bayoumi, Sulayma Albarwani, Saeed Al-Yahyaee, Afshin Aslani et al. "Genome-Wide Linkage Analysis of Hemodynamic Parameters Under Mental and Physical Stress in Extended Omani Arab Pedigrees: The Oman Family Study". Twin Research and Human Genetics 14, n.º 3 (1 de junho de 2011): 257–67. http://dx.doi.org/10.1375/twin.14.3.257.

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Background:We performed a genome-wide scan in a homogeneous Arab population to identify genomic regions linked to blood pressure (BP) and its intermediate phenotypes during mental and physical stress tests.Methods:The Oman Family Study subjects (N= 1277) were recruited from five extended families of ~10 generations. Hemodynamic phenotypes were computed from beat-to-beat BP, electrocardiography and impedance cardiography. Multi-point linkage was performed for resting, mental (word conflict test, WCT) and cold pressor (CPT) stress and their reactivity scores (s), using variance components decomposition-based methods implemented in SOLAR.Results:Genome-wide scans for BP phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT-linked cardiac output (LOD = 3.1) and systolic BP (LOD = 3.5). Evidence for suggestive linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), DBP (LOD = 2.4) and left ventricular ejection time (LVET), respectively. For △WCT, suggestive QTLs were detected for CO on chr11 (LOD = 2.5), LVET on chr3 (LOD = 2.0) and EDI on chr9 (LOD = 2.1). For CPT, suggestive QTLs for HR and LVET shared the same region on chr22 (LOD 2.3 and 2.8, respectively) and on chr9 (LOD = 2.3) for SBP, chr7 (LOD = 2.4) for SV and chr19 (LOD = 2.6) for CO. For △CPT, CO and TPR top signals were detected on chr15 and 10 (LOD; 2.40, 2.08) respectively. Conclusion: Mental stress revealed the largest number of significant and suggestive loci for normal BP reported to date. The study of BP and its intermediate phenotypes under mental and physical stress may help reveal the genes involved in the pathogenesis of essential hypertension.

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Neudorf, Ulrich, Angelika Bolte, Dieter Lang, Frank Hentrich e Achim A. Schmaltz. "Diagnostic findings and outcome in children with primary restrictive cardiomyopathy". Cardiology in the Young 6, n.º 1 (janeiro de 1996): 44–47. http://dx.doi.org/10.1017/s1047951100003231.

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SummaryRestrictive cardiomyopathy is a rare disease in children and adolescents. We have now encountered eight such cases in infants and children aged between nine months and 14 years. The reasons for admission to hospital were not very specific and included recurrent bronchitis, thoracic deformity, pathologic findings on routine electro-cardiography, or signs of cardiac failure. Despite two cases with atrial flutter, the characteristic electrocardiographic sign was a P-wave in lead II of about 0.6 to 1.5 m V. Echocardiographically, the leading feature was enlargement of the atriums, seen in cross-sectional and M-mode tracings. Diameters and functional parameters for the left ventricle, and the EF-slope of the mitral valve were normal. In four patients examined specifically for diis aspect, a typical E/A-ratio was found. Cardiac catheterization was performed in all patients. Left atrial or pulmonary capillary wedge pressures were all abnormal, and pulmonary arterial pressures ranged from 30 to 60 mm Hg. Calculated pulmonary resistances were 3 to 12 units per meter squared. End-diastolic left ventricular pressures were elevated, while comparable right-sided pressures were normal. Percutaneous endomyocardial biopsy was done in six patients and performed as an open biopsy in two. Only unspecified signs, such as myocytic hypertrophy or interstitial fibrosis, were found. At present, five of the children have died within two years of diagnosis. One boy has undergone cardiac transplantation success-fully. The two youngest children are still alive. As there is such a poor prognosis, and no alternative specific therapy is known, cardiac transplantation must be discussed with the family at an early stage, emphasizing its consequences.

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Hassan, Mohammed O., Riad A. Bayoumi, Juan C. Lopez-Alvarenga, Harold Snieder, Deepali Jaju, Saeed Al-Yahyaee, Saleh Al-Hadabi, Anthony G. Comuzzie e Sulayma Albarwani. "Heritability of Hemodynamic Reactivity to Laboratory Stressors in a Homogenous Arab Population: ‘Oman Family Study’". Twin Research and Human Genetics 12, n.º 6 (1 de dezembro de 2009): 541–48. http://dx.doi.org/10.1375/twin.12.6.541.

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AbstractBackground:Exaggerated cardiovascular reactivity to stressful stimuli may be a risk factor for the development of hypertension. The genetic influence on blood pressure (BP) reactivity to stress and its control mechanisms has been receiving considerable support. This study aims at examining the heritability of BP and its intermediate hemodynamic phenotypes to acute stress in a homogeneous Arab population.Methods:Parameters were computed from continuous BP, electrocardiography and impedance cardiography measurements, during rest, word conflict (WCT) and cold pressor (CPT) tests. Heritability estimates (h2) were obtained using the variance components-based approach implemented in the SOLAR software package.Results:Reactivity scores for WCT and CPT increased significantly (P< .05) for systolic (SBP), diastolic (DBP), heart rate (HR), cardiac output (CO), and total peripheral resistance (TPR). They decreased significantly (P< .05) for stroke volume (SV), left ventricular ejection time (LVET), end diastolic (EDI) and cardiac contractility (IC) indices. Univariate analysis detected heritability estimates that ranged from 0.19–0.35 for rest, 0.002–0.40 for WCT and 0.08–0.35 for CPT.Conclusion:In this unique cohort, resting as well as challenged cardiovascular phenotypes are significantly influenced by additive genetic effects. Heritability estimates for resting phenotypes are in a relatively narrow range, while h2for their reactivity is somewhat broader with lower estimates. Further analyses of this study may offer important opportunities for gene finding in hypertension.What is Known About the Topic:(1) cardiovascular reactivity to stress predicts cardiovascular disease; (2) genetic susceptibility plays an important role in stress reactivity. Family studies using the cold pressure test reported significant heritability for blood pressure.What this Study Adds:(1) this cohort is from five highly consanguineous isolated Arab pedigrees with genetically verified genealogical records and environmental homogeneity; (2) This is the first study to estimate heritability of detailed intermediate hemodynamic phenotypes that make up normal blood pressure.

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Giordano, Ugo, Salvatore Giannico, Attilio Turchetta, Fatma Hammad, Flaminia Calzolari e Armando Calzolari. "The influence of different surgical procedures on hypertension after repair of coarctation". Cardiology in the Young 15, n.º 5 (16 de setembro de 2005): 477–80. http://dx.doi.org/10.1017/s1047951105001332.

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We measured resting and exercise haemodynamics, as well as 24-hour ambulatory blood pressure, so as to study the influence on development of hypertension in children after repair of coarctation by either construction of a subclavian flap or end-to-end anastamosis. The patients in both groups were studied a mean time of 13 years after surgery. Thus, we divided 43 children who had undergone surgical repair of coarctation, and who were not on antihypertensive therapy, into a group of 22 patients who had undergone subclavian flap repair, with a mean age of 14 plus or minus 2.6 years, and another group of 21 patients undergoing end-to-end anastomosis, with a mean age of 13.5 plus or minus 3.9 years. We examined blood pressure at rest and during exercise, along with the measurement of cardiac output using impedance cardiography, and during 24-hour ambulatory monitoring. We recorded systolic and diastolic blood pressures, pulse pressure, cardiac output and total peripheral vascular resistance at rest and at peak exercise. During ambulatory monitoring, we measured mean pressures over 24 hours, in daytime and nighttime, 24-hour pulse pressure, and 24-hour mean arterial pressure. Student's t test was used to judge significance, accepting this when p was less than 0.05. The group repaired using the subclavian flap showed significantly disadvantageous differences for diastolic blood pressure at rest, systolic blood pressure at peak exercise and for 24-hour systolic and diastolic blood pressure, 24-hour mean arterial pressure, and daytime and nighttime systolic blood pressure during ambulatory monitoring. Our findings suggest that, after repair using the subclavian flap in comparison to end-to-end anastomosis, patients show a higher incidence of late hypertension, both during exercise and ambulatory monitoring. The data indicate different residual aortic stiffnesses, these being lower after end-to-end anastomosis, which may be due to the greater resection of the abnormal aortic tissue when coarctation is repaired using the latter technique.

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Tacyildiz, N., T. Ucar, D. Ozyoruk, G. Yavuz, E. Unal, S. Atalay, G. Ozelci Kavas, P. Aribal, H. Dincaslan e A. Cavdar. "Effect of selenium on anthracycline induced cardiotoxicity in children that treated for cancer: Correlation with pro-brain natriuretic peptide levels". Journal of Clinical Oncology 27, n.º 15_suppl (20 de maio de 2009): 10061. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.10061.

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10061 Background: High cumulative doses of an anthracyclin (300–500 mg/m2) are used in the several treatment protocols of children with Cancer. Probrain natriuretic peptit (Pro-BNP), is relased by cardiac cells and elevated even before overt cardiac distress symptoms. Selenium, is an antioxidant which its’ absence cause cardiomyopathy in people living in the poor selenium soil area. Aim 1: Assesment of anthracycline-induced cardiotoxicity with Pro-BNP levels, correlated with echo-cardiographic (ECHO) findings. Aim 2: Determine possible effects of selenium levels and supplemantation on cardiac toxicity. Methods: Plasma levels of Pro-BNP have been measured in 58 pediatric cancer patients (leukemias, lymphomas,solid tumors; 38 boys, 20 girls; between 2–18 years, median:12) after completed their anthracycline containing regimens. Serum selenium levels examined in 12 patients (six patients were with high and other six with normal pro-BNP levels). Three of four Patients with low level of selenium showed cardiac failure according to ECHO and supplemanted with selenium besides digoxine, ACE inhibitors. Results: Eleven patients have found with high pro-BNP levels (120–8022 pg/ml; normal: lower than 120 pg/ml).Six of these patients (with 170–8022 pg/ml, median:798pg/ml pro-BNP) and other six patients with normal levels of pro-BNP (10–74pg/ml, median: 67pg/ml) examined for their serum selenium levels. All patients with normal pro-BNP levels have found in normal levels of selenium levels (71–150 μg/L,median:125 μg/L). Four patients in high pro-BNP group showed low levels of selenium (52–129 μg/L; median:67.5 μg/L). Since three of that four patients have cardiac failure, treated accordingly and supplemented with 100 μg/day selenium to maintain normal levels. During follow-up periods of 27; 8 and 2 months, all 3 patients are doing well with normal ECHO finding. Two patients reached normal Pro-BNP levels while one of them has 80 % decrease. Conclusions: Serum Pro-BNP levels can be used as a marker for anthracycline toxicity and as follow-up marker for protective agents. Selenium suplemantation may have a potential role to protect and/or overcome the difficulties related anthracyclin-induced toxicities. No significant financial relationships to disclose.

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Sumbel, Lydia, Aanchal Wats, Mohammed Salameh, Elumalai Appachi e Utpal Bhalala. "Thoracic Fluid Content (TFC) Measurement Using Impedance Cardiography Predicts Outcomes in Critically Ill Children". Frontiers in Pediatrics 8 (25 de fevereiro de 2021). http://dx.doi.org/10.3389/fped.2020.564902.

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Objective: Conventional methods of fluid assessment in critically ill children are difficult and/or inaccurate. Impedance cardiography has capability of measuring thoracic fluid content (TFC). There is an insufficient literature reporting correlation between TFC and conventional methods of fluid balance and whether TFC predicts outcomes in critically ill children. We hypothesized that TFC correlates with indices of fluid balance [FIMO (Fluid Intake Minus Output) and AFIMO (Adjusted Fluid Intake Minus Output)] and is a predictor of outcomes in critically ill children.Design: Retrospective chart review.Setting: Pediatric intensive care unit of a tertiary care teaching hospital.Patients: Children <21 years, admitted to our Pediatric Intensive Care Unit (PICU) between July- November 2018 with acute respiratory failure and/or shock and who were monitored for fluid status using ICON® monitor.Interventions: None.Measurements and Main Results: We collected demographic information, data on daily and cumulative fluid balance (CFB), ventilator, PICU and hospital days, occurrence of multi-organ dysfunction syndrome (MODS), and mortality. We calculated AFIMO using insensible fluid loss. We analyzed data using correlation coefficient, chi-square test and multiple linear regression analysis. We analyzed a total 327 recordings of TFC, FIMO and AFIMO as daily records of fluid balance in 61 critically ill children during the study period. The initial TFC, FIMO, and AFIMO in ml [median (IQR)] were 30(23, 44), 300(268, 325), and 21.05(−171.3, 240.2), respectively. The peak TFC, FIMO, and AFIMO in ml were 36(26, 24), 322(286, 334), and 108.8(−143.6, 324.4) respectively. The initial CFB was 1134.2(325.6, 2774.4). TFC did not correlate well with FIMO or AFIMO (correlation coefficient of 0.02 and −0.03, respectively), but a significant proportion of patients with high TFC exhibited pulmonary plethora on x-ray chest (as defined by increased bronchovascular markings and/or presence of pleural effusion) (p = 0.015). The multiple linear regression analysis revealed that initial and peak TFC and peak and mean FIMO and AFIMO predicted outcomes (ventilator days, length of PICU, and hospital days) in critically ill children (p < 0.05).Conclusions: In our cohort of critically ill children with respiratory failure and/or shock, TFC did not correlate with conventional measures of fluid balance (FIMO/AFIMO), but a significant proportion of patients with high TFC had pulmonary plethora on chest x-ray. Both initial and peak TFC predicted outcomes in critically ill children.

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Blohm, Martin Ernst, Denise Obrecht, Jana Hartwich, Goetz Christoph Mueller, Jan Felix Kersten, Jochen Weil e Dominique Singer. "Impedance cardiography (electrical velocimetry) and transthoracic echocardiography for non-invasive cardiac output monitoring in pediatric intensive care patients: a prospective single-center observational study". Critical Care 18, n.º 6 (19 de novembro de 2014). http://dx.doi.org/10.1186/s13054-014-0603-0.

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"FECG/Doppler Cardiography". Journal of Perinatal Medicine 15, s1 (janeiro de 1987): 32–38. http://dx.doi.org/10.1515/jpme.1987.15.s1.32.

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Berisha, Gazmend, Rønnaug Solberg, Claus Klingenberg e Anne Lee Solevåg. "Neonatal Impedance Cardiography in Asphyxiated Piglets—A Feasibility Study". Frontiers in Pediatrics 10 (25 de fevereiro de 2022). http://dx.doi.org/10.3389/fped.2022.804353.

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ObjectivesImpedance cardiography (ICG) is a non-invasive method for continuous cardiac output measurement and has the potential to improve monitoring and treatment of sick neonates. PhysioFlow® is a signal-morphology ICG-system showing promising results in adults with low and high cardiac output, but no data from neonates or neonatal models exist. The aim of this study was to investigate PhysioFlow® feasibility in asphyxiated newborn piglets.MethodsFifteen piglets, under continuous arterial heart rate (HR) and blood pressure (BP) monitoring, were asphyxiated until asystole. Cardiopulmonary resuscitation was performed and the piglets monitored after return of spontaneous circulation (ROSC). Arterial lactate was measured at baseline, every 5 min throughout asphyxiation, at asystole, and at 10 min and later every 30 min after ROSC. PhysioFlow® measured cardiac stroke volume (SV) and HR, and calculated cardiac index (CI) (L/m2/min). Registrations with a signal quality < 75% were excluded, and registrations recorded for 30 min from start of asphyxia analyzed. Pearson correlations were calculated for CI; and HR, mean BP and blood lactate.ResultsThe piglets were asphyxiated for median (interquartile range) 30 (20–35) min and had a lactate at asystole of 15.0 (9.1–17.0) mmol/L. Out of a total of 20.991 registrations in all animals combined, there were 10.148 (48.3%) registrations with a signal quality ≥ 75%. Signal quality ≥ 75% varied in individual piglets from 7 to 82% of registrations. We analyzed 1.254 registrations recorded 30 min from initiation of asphyxia, i.e., in piglets with brief asphyxia times, this included cardiopulmonary resuscitation and post-ROSC observation. There was a positive correlation between CI and SVI (r = 0.90, p < 0.001), and between CI and HR (r = 0.446, p < 0.001). There was no correlation between CI, or mean BP or lactate (p = 0.98 and 0.51, respectively).ConclusionAbout half of ICG-registrations in asphyxiated piglets were of good quality. However, signal quality was highly variable between piglets. In total, there was a higher proportion of reliable ICG-registrations than reported from clinical delivery room studies using electrical velocimetry. Our data are physiologically plausible and supports further research evaluating PhysioFlow® for cardiac output monitoring in perinatal asphyxia. In particular, factors influencing inter-individual variations in signal quality should be explored.

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Banerjee, Jayanta, Nidal Khatib, Roshni C. Mansfield, Sundar Sathiyamurthy, Ujwal Kariholu e Christoph Lees. "Continuous non-invasive measurement of cardiac output in neonatal intensive care using regional impedance cardiography: a prospective observational study". Archives of Disease in Childhood - Fetal and Neonatal Edition, 14 de dezembro de 2023, fetalneonatal—2023–325941. http://dx.doi.org/10.1136/archdischild-2023-325941.

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ObjectivesTo compare agreement between echocardiography and regional impedance cardiography (RIC)-derived cardiac output (CO), and to construct indicative normative ranges of CO for gestational age groups.Design, setting and participantsProspective cohort observational study performed in a tertiary centre in London, UK, including neonates born between 25 and 42 weeks’ gestational age.ExposuresNeonates on the postnatal ward had 2 hours of RIC monitoring; neonates in intensive care had RIC monitoring for the first 72 hours, then weekly for 2 hours, with concomitant echocardiography measures.Main outcomes and measuresRIC was used to measure CO continuously. Statistical analyses were performed using R (V.4.2.2; R Core Team 2022). RIC-derived CO and echocardiography-derived CO were compared using Pearson’s correlations and Bland-Altman analyses. Differences in RIC-derived CO between infants born extremely, very and late preterm were assessed using analyses of variance and mixed-effects modelling.Results127 neonates (22 extremely, 46 very, 29 late preterm and 30 term) were included. RIC and echocardiography-measured weight-adjusted CO were correlated (r=0.62, p<0.001) with a Bland-Altman bias of −31 mL/min/kg (limits of agreement −322 to 261 mL/min/kg). The RIC-derived CO fell over 12 hours, then increased until 72 hours after birth. The 72-hour weight-adjusted mean CO was higher in extremely preterm (424±158 mL/min/kg) compared with very (325±131 mL/min/kg, p<0.001) and late preterm (237±81 mL/min/kg, p<0.001) neonates; this difference disappeared by 2–3 weeks of age.ConclusionsRIC is valid for continuous, non-invasive CO measurement in neonates. Indicative normative CO ranges could help clinicians to make more informed haemodynamic management decisions, which should be explored in future studies.Trial registration numberNCT04064177.

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Woodman, Hannah M., Corlyn Lee, Ayesha N. Ahmed, Bassit A. Malik, Sophie Mellor, Louise J. Brown, Leanne Gentle e Amer Harky. "Cardiac output monitoring in paediatric cardiac surgery: a review". Cardiology in the Young, 5 de janeiro de 2021, 1–8. http://dx.doi.org/10.1017/s1047951120004680.

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Abstract The aim of this review is to present the current options for cardiac output (CO) monitoring in children undergoing cardiac surgery. Current technologies for monitoring identified were a range of invasive, minimally invasive, and non-invasive technologies. These include pulmonary artery catheter, transoesophageal echocardiography, pulse contour analysis, electrical cardiography, and thoracic bioreactance. A literature search was conducted using evidence databases which identified two current guidelines; the NHS Greater Glasgow and Clyde guideline and Royal College of Anaesthetics Guideline. These were appraised using the AGREE II tool and the evidence identified was used to create an overview summary of each technological option for CO monitoring. There is limited evidence regarding the accuracy of modalities available for CO monitoring in paediatric patients during cardiac surgery. Each technology has advantages and disadvantages; however, none could be championed as the most beneficial. Furthermore, a gold standard for CO monitoring has not yet been identified for paediatric populations, nor is it apparent whether one modality is preferable based on the available evidence. Additional evidence using a standardised method for comparing CO measurements should be conducted in order to determine the best option for CO monitoring in paediatrics. Furthermore, cost-effectiveness assessment of each modality should be conducted. Only then will it be possible for clear, evidence-based guidance to be written.

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Senthil, V., e R. Sanjeev Pandian. "CORONARY ARTERY BYPASS SURGERY IN YOUNG ADULT A INSTITUTIONAL RETROSPECTIVE STUDY". INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 1 de maio de 2023, 68–70. http://dx.doi.org/10.36106/ijsr/8414297.

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Objective: To study the overall causes, perioperative mortality, post operative complications, prognosis, outcome and follow up in a young adult present with coronary artery disease under going coronary artery bypass in our institute. Methods: Asum of 56 patient who are 40 years and less then 40 years who underwent coronary artery bypass surgery between January 2017 to December 2022 who's clinical case history, coronary angiography, pre operative and post operative echo cardiography, operative notes, post operative notes, outpatient follow up are collected from our computer stored data and from medical record department in our college and from Tamilnadu chief minister comprehensive health insurance scheme institutional Web site data base Results: Out of 56 patient,8 Female(14.3%) and 48 Male(85.7%),mean age 37.1 years (range 32 – 40 years),Diabetic 39 Patient (62.5%),Hypertensive 21 patient (37.5%) 7 / 8 women(87.5%) diabetic ,3/8 women both diabetic and hypertensive. Out of 48 male 47(97.9%) chronic smoker, 45 (93.8%) chronic alcoholic,44 (91.6%) both alcoholic and smoke , no women in this study neither alcoholic or smoker, 3patient (5.35%) hyperlipidaemia, 2 patient (3.57%) hypothyroidism all 2/8 (25%) are female,2 patient on haemodialysis for kidney disease, 1patient with bilateral renal artery stenosis, 1 patient with right innominate, right subclavian, bilateral carotid stenosis. Left ventricular function was impaired with ejection fraction average 46% (range 30% - 55%). 1 patient with ventricular septal rupture.2 patient with post coronary stent, The indication for surgery was triple vessel disease in 30 patient(53.57%) ,double vessel disease in 20 patient(35.7%),single vessel disease in 1 patient, single vessel disease with ventricular septal rupture in 1 patient, left main coronary artery stenosis in 4 patient(7%). Surgical procedure Off pump coronary artery bypass surgery in 51 patient(91%), On pump beating heart coronary artery bypass surgery in 2 patient (3.57%),On pump arrested heart coronary artery bypass surgery in 3 patient(5.35%). A total of 132 grafts were constructed(mean 2.4 grafts per patient),35 (27%) of them being arterial only left internal mammary artery harvested and other grafts were great saphenous vein. Post operative average ventilation time18hrs (range 18hrs to 24hrs), There were 5(8.9%)hospital death and 5(8.9%) late death in follow up, total 10 (17.8%) death till now. Conclusion: Most common cause for young coronary artery disease from our clinical history is found to be early onset diabetic mellitus and from our personal history chronic smoking and chronic alcoholism, intra operative mortality and morbidity is high in patient present with severe left ventricular dysfunction, coronary artery diseases induced complication and additional comorbidity, however most of patient recovered from post operative cardiovascular lethal or morbid event and on regular clinical follow up

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