Artigos de revistas sobre o tema "P-PBPK model"
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Mi, Kun, Shanju Pu, Yixuan Hou, Lei Sun, Kaixiang Zhou, Wenjin Ma, Xiangyue Xu et al. "Optimization and Validation of Dosage Regimen for Ceftiofur against Pasteurella multocida in Swine by Physiological Based Pharmacokinetic–Pharmacodynamic Model". International Journal of Molecular Sciences 23, n.º 7 (28 de março de 2022): 3722. http://dx.doi.org/10.3390/ijms23073722.
Texto completo da fonteJeong, Yoo-Seong, Min-Soo Kim, Nora Lee, Areum Lee, Yoon-Jee Chae, Suk-Jae Chung e Kyeong-Ryoon Lee. "Development of Physiologically Based Pharmacokinetic Model for Orally Administered Fexuprazan in Humans". Pharmaceutics 13, n.º 6 (29 de maio de 2021): 813. http://dx.doi.org/10.3390/pharmaceutics13060813.
Texto completo da fonteDallmann, A., P. Mian, P. Annaert, M. Pfister, K. Allegaert e J. van den Anker. "P21 PBPK modeling in pregnancy: achievements, shortcomings and future perspectives". Archives of Disease in Childhood 104, n.º 6 (17 de maio de 2019): e25.2-e25. http://dx.doi.org/10.1136/archdischild-2019-esdppp.59.
Texto completo da fonteNauwelaerts, Nina, Julia Macente, Neel Deferm, Rodolfo Hernandes Bonan, Miao-Chan Huang, Martje Van Neste, David Bibi et al. "Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project". Pharmaceutics 15, n.º 5 (11 de maio de 2023): 1469. http://dx.doi.org/10.3390/pharmaceutics15051469.
Texto completo da fonteKovar, Lukas, Christina Schräpel, Dominik Selzer, Yvonne Kohl, Robert Bals, Matthias Schwab e Thorsten Lehr. "Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates". Pharmaceutics 12, n.º 6 (23 de junho de 2020): 578. http://dx.doi.org/10.3390/pharmaceutics12060578.
Texto completo da fontePilla Reddy, Venkatesh, Adrian J. Fretland, Diansong Zhou, Shringi Sharma, Buyun Chen, Karthick Vishwanathan, Dermot F. McGinnity, Yan Xu e Joseph A. Ware. "Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors". Cancer Chemotherapy and Pharmacology 88, n.º 3 (2 de junho de 2021): 451–64. http://dx.doi.org/10.1007/s00280-021-04302-5.
Texto completo da fonteYang, Yiting, Ping Li, Zexin Zhang, Zhongjian Wang, Li Liu e Xiaodong Liu. "Prediction of Cyclosporin-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Model Characterizing Interplay of Drug Transporters and Enzymes". International Journal of Molecular Sciences 21, n.º 19 (24 de setembro de 2020): 7023. http://dx.doi.org/10.3390/ijms21197023.
Texto completo da fonteWills, Kenneth H., Stephen J. Behan, Michael J. Nance, Jessica L. Dawson, Thomas M. Polasek, Ashley M. Hopkins, Madelé van Dyk e Andrew Rowland. "Combining Therapeutic Drug Monitoring and Pharmacokinetic Modelling Deconvolutes Physiological and Environmental Sources of Variability in Clozapine Exposure". Pharmaceutics 14, n.º 1 (27 de dezembro de 2021): 47. http://dx.doi.org/10.3390/pharmaceutics14010047.
Texto completo da fonteKim, Min-Soo, Nora Lee, Areum Lee, Yoon-Jee Chae, Suk-Jae Chung e Kyeong-Ryoon Lee. "Model-Based Prediction of Acid Suppression and Proposal of a New Dosing Regimen of Fexuprazan in Humans". Pharmaceuticals 15, n.º 6 (3 de junho de 2022): 709. http://dx.doi.org/10.3390/ph15060709.
Texto completo da fonteBachelet, Delphine, Marc-André Verner, Monica Neri, Émilie Cordina Duverger, Corinne Charlier, Patrick Arveux, Sami Haddad e Pascal Guénel. "Breast Cancer and Exposure to Organochlorines in the CECILE Study: Associations with Plasma Levels Measured at the Time of Diagnosis and Estimated during Adolescence". International Journal of Environmental Research and Public Health 16, n.º 2 (18 de janeiro de 2019): 271. http://dx.doi.org/10.3390/ijerph16020271.
Texto completo da fonteBerghausen, Joerg, Frank Hans Seiler, Nathalie Gobeau e Bernard Faller. "Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range". ADMET & DMPK 4, n.º 1 (30 de março de 2016): 35. http://dx.doi.org/10.5599/admet.4.1.258.
Texto completo da fonteLiu, Rongrui, Tim R. Zacharewski, Rory B. Conolly e Qiang Zhang. "A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds". Toxics 10, n.º 11 (17 de novembro de 2022): 700. http://dx.doi.org/10.3390/toxics10110700.
Texto completo da fonteCiffroy, Philippe, T. Tanaka, E. Johansson e C. Brochot. "Linking fate model in freshwater and PBPK model to assess human internal dosimetry of B(a)P associated with drinking water". Environmental Geochemistry and Health 33, n.º 4 (2 de abril de 2011): 371–87. http://dx.doi.org/10.1007/s10653-011-9382-6.
Texto completo da fonteGaohua, Lu, Khaled Abduljalil, Masoud Jamei, Trevor N. Johnson e Amin Rostami-Hodjegan. "A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4". British Journal of Clinical Pharmacology 74, n.º 5 (9 de outubro de 2012): 873–85. http://dx.doi.org/10.1111/j.1365-2125.2012.04363.x.
Texto completo da fonteTempleton, Ian E., Terry Podoll, Cecile Marie Krejsa e J. Greg Slatter. "A Mechanistic Physiologically Based Pharmacokinetic (PBPK) Drug Interaction Model for the Mouse Double Minute 2 (MDM2) Inhibitor KRT-232". Blood 136, Supplement 1 (5 de novembro de 2020): 9–10. http://dx.doi.org/10.1182/blood-2020-135987.
Texto completo da fonteSmith, Jordan N., Kari A. Gaither e Paritosh Pande. "Competitive Metabolism of Polycyclic Aromatic Hydrocarbons (PAHs): An Assessment Using In Vitro Metabolism and Physiologically Based Pharmacokinetic (PBPK) Modeling". International Journal of Environmental Research and Public Health 19, n.º 14 (6 de julho de 2022): 8266. http://dx.doi.org/10.3390/ijerph19148266.
Texto completo da fonteRusso, Francesca M., Felix De Bie, Ryan Hodges, Alan Flake e Jan Deprest. "Sildenafil for Antenatal Treatment of Congenital Diaphragmatic Hernia: From Bench to Bedside". Current Pharmaceutical Design 25, n.º 5 (3 de junho de 2019): 601–8. http://dx.doi.org/10.2174/1381612825666190320151856.
Texto completo da fonteKato, Takafumi, Tsuyoshi Mikkaichi, Yasushi Yoshigae, Noriko Okudaira, Takako Shimizu, Takashi Izumi, Shuichi Ando e Yoshiaki Matsumoto. "Quantitative analysis of an impact of P-glycoprotein on edoxaban's disposition using a human physiologically based pharmacokinetic (PBPK) model". International Journal of Pharmaceutics 597 (março de 2021): 120349. http://dx.doi.org/10.1016/j.ijpharm.2021.120349.
Texto completo da fonteVerscheijden, Laurens F. M., Jan B. Koenderink, Saskia N. de Wildt e Frans G. M. Russel. "Differences in P-glycoprotein activity in human and rodent blood–brain barrier assessed by mechanistic modelling". Archives of Toxicology 95, n.º 9 (15 de julho de 2021): 3015–29. http://dx.doi.org/10.1007/s00204-021-03115-y.
Texto completo da fonteNguyen, Dung N., Xiusheng Miao, Mindy Magee, Guoying Tai, Peter D. Gorycki e Katy P. Moore. "1315. No Dose Adjustment of Metformin with Fostemsavir Coadministration Based on Mechanistic Static and Physiologically Based Pharmacokinetic Models". Open Forum Infectious Diseases 7, Supplement_1 (1 de outubro de 2020): S669. http://dx.doi.org/10.1093/ofid/ofaa439.1497.
Texto completo da fonteLiu, Jian, Swan Lin, Anthony Huynh e Weiwei Tan. "Effects of H2-Receptor Antagonists on the Exposure of Dacomitinib". Pharmaceutics 16, n.º 1 (17 de janeiro de 2024): 118. http://dx.doi.org/10.3390/pharmaceutics16010118.
Texto completo da fonteDesai, Amit, Laura Kovanda, Christopher Lademacher, William Hope, Michael Neely, Peter Bonate e Andrea Edginton. "1396. Predictions of Isavuconazonium Sulfate Dosage in Patients Aged 6 Months: <18 Years by Physiologically Based Pharmacokinetic Modeling". Open Forum Infectious Diseases 5, suppl_1 (novembro de 2018): S429—S430. http://dx.doi.org/10.1093/ofid/ofy210.1227.
Texto completo da fonteZhou, Kaixiang, Meixia Huo, Wenjin Ma, Kun Mi, Xiangyue Xu, Samah Attia Algharib, Shuyu Xie e Lingli Huang. "Application of a Physiologically Based Pharmacokinetic Model to Develop a Veterinary Amorphous Enrofloxacin Solid Dispersion". Pharmaceutics 13, n.º 5 (22 de abril de 2021): 602. http://dx.doi.org/10.3390/pharmaceutics13050602.
Texto completo da fonteMian, P., K. Allegaert, S. Conings, P. Annaert, D. Tibboel, M. Pfister, K. van Calsteren, JN van den Anker e A. Dallmann. "P66 Characterization of the pharmacokinetics of acetaminophen and its metabolites in the fetus through integration of placental transfer in a physiologically based pharmacokinetic model". Archives of Disease in Childhood 104, n.º 6 (17 de maio de 2019): e44.2-e45. http://dx.doi.org/10.1136/archdischild-2019-esdppp.104.
Texto completo da fonteLi, Yuezhe, A. Katharina Wilkins, Tim Knab e Joseph P. Boni. "Abstract 875: Quantitative systems pharmacology modeling of loncastuximab tesirine combined with mosunetuzumab and glofitamab helps guide dosing for patients with DLBCL". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 875. http://dx.doi.org/10.1158/1538-7445.am2024-875.
Texto completo da fonteTürk, Denise, Nina Hanke e Thorsten Lehr. "A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions". Pharmaceutics 12, n.º 11 (10 de novembro de 2020): 1074. http://dx.doi.org/10.3390/pharmaceutics12111074.
Texto completo da fonteMarok, Fatima Zahra, Jan-Georg Wojtyniak, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Johanna Weiss, Walter Emil Haefeli e Thorsten Lehr. "A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators". Pharmaceutics 15, n.º 2 (17 de fevereiro de 2023): 679. http://dx.doi.org/10.3390/pharmaceutics15020679.
Texto completo da fontePepin, Xavier J. H., Natalie J. Sanderson, Alexander Blanazs, Shveta Grover, Timothy G. Ingallinera e James C. Mann. "Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part I. Mechanistic modelling of drug product dissolution to derive a P-PSD for PBPK model input". European Journal of Pharmaceutics and Biopharmaceutics 142 (setembro de 2019): 421–34. http://dx.doi.org/10.1016/j.ejpb.2019.07.014.
Texto completo da fonteFenneteau, F., J. Li, L. Couture, J. Turgeon e F. Nekka. "Prediction of the disposition of a P-gp substrate in wild-type and knockout mice tissues: Development of a physiologically based pharmacokinetic (PBPK) model and its global sensitivity analysis". PAMM 7, n.º 1 (dezembro de 2007): 1121905–6. http://dx.doi.org/10.1002/pamm.200700608.
Texto completo da fonteXie, Yuewu, Huixiang Liu, Xiaoyue Chen e Jie Xing. "The Effect of Gastric pH on the Pharmacokinetics-pharmacodynamics of Naphthoquine in Rodents, as well as in Human Predicted Using a PBPK Model". Current Drug Metabolism 22, n.º 5 (15 de julho de 2021): 363–71. http://dx.doi.org/10.2174/1389200222666210129102411.
Texto completo da fontedel Río, A., C. García-de-la-Mària, J. M. Entenza, O. Gasch, Y. Armero, D. Soy, C. A. Mestres et al. "Fosfomycin plus β-Lactams as Synergistic Bactericidal Combinations for Experimental Endocarditis Due to Methicillin-Resistant and Glycopeptide-Intermediate Staphylococcus aureus". Antimicrobial Agents and Chemotherapy 60, n.º 1 (2 de novembro de 2015): 478–86. http://dx.doi.org/10.1128/aac.02139-15.
Texto completo da fonteDennison, James E., Philip L. Bigelow e Melvin E. Andersen. "Occupational exposure limits in the context of solvent mixtures, consumption of ethanol, and target tissue dose". Toxicology and Industrial Health 20, n.º 6-10 (julho de 2004): 165–75. http://dx.doi.org/10.1191/0748233704th203oa.
Texto completo da fonteHu, Jing, Zhengbao Zhang, Senwei Lin, Qiuhuan Zhang, Guoxia Du, Ruishan Zhou, Xiaohan Qu, Guojiang Xu, Ying Yang e Yongming Cai. "Application of All-Ages Lead Model Based on Monte Carlo Simulation of Preschool Children’s Exposure to Lead in Guangdong Province, China". Sustainability 15, n.º 2 (6 de janeiro de 2023): 1068. http://dx.doi.org/10.3390/su15021068.
Texto completo da fonteIbrahim, A. H., H. Barry e C. M. Hughes. "A cross-sectional survey of general practitioners’ experiences with, views of, and attitudes towards, practice-based pharmacists". International Journal of Pharmacy Practice 29, Supplement_1 (26 de março de 2021): i24—i25. http://dx.doi.org/10.1093/ijpp/riab015.029.
Texto completo da fonteJayawardena, Thilina U., Lei Wang, K. K. Asanka Sanjeewa, Sang In Kang, Jung-Suck Lee e You-Jin Jeon. "Antioxidant Potential of Sulfated Polysaccharides from Padina boryana; Protective Effect against Oxidative Stress in In Vitro and In Vivo Zebrafish Model". Marine Drugs 18, n.º 4 (14 de abril de 2020): 212. http://dx.doi.org/10.3390/md18040212.
Texto completo da fonteAudi, Said H., Anthony Cammarata, Anne V. Clough, Ranjan K. Dash e Elizabeth R. Jacobs. "Quantification of mitochondrial membrane potential in the isolated rat lung using rhodamine 6G". Journal of Applied Physiology 128, n.º 4 (1 de abril de 2020): 892–906. http://dx.doi.org/10.1152/japplphysiol.00789.2019.
Texto completo da fonteTudora, Anabella, e Franz-Josef Hambsch. "Parameterisation of the residual temperature distribution based on the modelling of successive emission of prompt neutrons". EPJ Web of Conferences 169 (2018): 00025. http://dx.doi.org/10.1051/epjconf/201816900025.
Texto completo da fonteShea, T. C., J. R. Mason, A. M. Storniolo, B. Newton, M. Breslin, M. Mullen, D. M. Ward, L. Miller, M. Christian e R. Taetle. "Sequential cycles of high-dose carboplatin administered with recombinant human granulocyte-macrophage colony-stimulating factor and repeated infusions of autologous peripheral-blood progenitor cells: a novel and effective method for delivering multiple courses of dose-intensive therapy." Journal of Clinical Oncology 10, n.º 3 (março de 1992): 464–73. http://dx.doi.org/10.1200/jco.1992.10.3.464.
Texto completo da fonteKallidaikurichi Srinivasan, Karthikeyan, Anthony Gallagher, Niall O’Brien, Vinod Sudir, Nick Barrett, Raymund O’Connor, Francesca Holt, Peter Lee, Brian O’Donnell e George Shorten. "Proficiency-based progression training: an ‘end to end’ model for decreasing error applied to achievement of effective epidural analgesia during labour: a randomised control study". BMJ Open 8, n.º 10 (outubro de 2018): e020099. http://dx.doi.org/10.1136/bmjopen-2017-020099.
Texto completo da fonteHanke, Nina, Sebastian Frechen, Daniel Moj, Hannah Britz, Thomas Eissing, Thomas Wendl e Thorsten Lehr. "PBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin". CPT: Pharmacometrics & Systems Pharmacology 7, n.º 10 (7 de setembro de 2018): 647–59. http://dx.doi.org/10.1002/psp4.12343.
Texto completo da fonteZubair, Abba, Rhonda Grant, Han Tun, Candido Rivera, Alvaro Moreno-aspitia, Vivek Roy, Gerry Colon-Otero e Lawrence Solberg. "Platelet Count Is a Sensitive Predictor of Bone Marrow Reserve and Autologous Peripheral Blood Progenitor Cell Mobilization." Blood 106, n.º 11 (16 de novembro de 2005): 5280. http://dx.doi.org/10.1182/blood.v106.11.5280.5280.
Texto completo da fonteLiu, Xingbang, e Yong He. "Effect and Clinical Value of Protective Motivation Intervention Rehabilitation Model on Pain Perception and Dysfunction in Patients with Lumbar Disc Herniation: Based on a Retrospective Cohort Study". Computational and Mathematical Methods in Medicine 2022 (30 de agosto de 2022): 1–8. http://dx.doi.org/10.1155/2022/5911889.
Texto completo da fonteWeaver, CH, B. Hazelton, R. Birch, P. Palmer, C. Allen, L. Schwartzberg e W. West. "An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy". Blood 86, n.º 10 (15 de novembro de 1995): 3961–69. http://dx.doi.org/10.1182/blood.v86.10.3961.bloodjournal86103961.
Texto completo da fonteGlass, Bertram, Lutz Uharek, Matthias Zeis, Peter Dreger, Helmut Löffler, Jörg Steinmann e Norbert Schmitz. "Allogeneic Peripheral Blood Progenitor Cell Transplantation in a Murine Model: Evidence for an Improved Graft-Versus-Leukemia Effect". Blood 90, n.º 4 (15 de agosto de 1997): 1694–700. http://dx.doi.org/10.1182/blood.v90.4.1694.
Texto completo da fonteGlass, Bertram, Lutz Uharek, Matthias Zeis, Peter Dreger, Helmut Löffler, Jörg Steinmann e Norbert Schmitz. "Allogeneic Peripheral Blood Progenitor Cell Transplantation in a Murine Model: Evidence for an Improved Graft-Versus-Leukemia Effect". Blood 90, n.º 4 (15 de agosto de 1997): 1694–700. http://dx.doi.org/10.1182/blood.v90.4.1694.1694_1694_1700.
Texto completo da fonteSchiedlmeier, B., K. Kühlcke, H. G. Eckert, C. Baum, W. J. Zeller e S. Fruehauf. "Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice". Blood 95, n.º 4 (15 de fevereiro de 2000): 1237–48. http://dx.doi.org/10.1182/blood.v95.4.1237.
Texto completo da fonteGubanova, M. V., N. N. Kushnarenko e T. M. Karavaeva. "Clinical significance of 24-hour blood pressure monitoring in prediction of hypertension development in patients with gout". Siberian Journal of Clinical and Experimental Medicine 36, n.º 3 (7 de outubro de 2021): 104–10. http://dx.doi.org/10.29001/2073-8552-2021-36-3-104-110.
Texto completo da fonteSeeger, Timon, Marlon Veldwijk, Gary Bridger, Gary Calandra, Hartmut Goldschmidt, Anthony Ho e Stefan Fruehauf. "The CXCR4 Antagonist AMD3100 Mobilizes a More Primitive Subset of CD34+ Cells Than G-CSF." Blood 106, n.º 11 (16 de novembro de 2005): 1969. http://dx.doi.org/10.1182/blood.v106.11.1969.1969.
Texto completo da fonteGoldberg, Joel, Christopher Bethel, Andrea M. Hujer, Steven Marshall, Magdalena A. Taracila, Krisztina M. Papp-Wallce, Vijay Kumar, Focco van den Akker, Mark Plummer e Robert A. Bonomo. "1256. In Vivo Activity and Structural Characterization of a New Generation γ-Lactam Siderophore Antibiotic Against Multidrug-Resistant Gram-Negative Bacteria and Acinetobacter spp". Open Forum Infectious Diseases 7, Supplement_1 (1 de outubro de 2020): S645. http://dx.doi.org/10.1093/ofid/ofaa439.1440.
Texto completo da fonteWilmsmeier, Lisa, Jeannine Von Der Born, Rizky I. Sugianto, Carl Grabitz, Bernhard Mw Schmidt, Ana Celine Braun, Denise Homeyer, Uwe Tegtbur e Anette Melk. "SIGNIFICANT INCREASES IN PERIPHERAL AND CENTRAL BLOOD PRESSURE IN CHILDREN AT MUCH LOWER BODY MASS INDEX THAN EXPECTED". Journal of Hypertension 42, Suppl 1 (maio de 2024): e11. http://dx.doi.org/10.1097/01.hjh.0001019420.16281.8a.
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