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Bibliografias temáticas / Osteoclasts / Teses / dissertações

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Teses / dissertações sobre o tema "Osteoclasts"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de julho de 2025

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1

O'Brien, Elizabeth Ann. "Regulation of osteoclast activity : differential adhesion of osteoclasts to the bone surface." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343930.

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2

Rowlands, Marit-Naomi. "In vitro production of osteoclasts." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250270.

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3

Nesbitt, Stephen Anthony. "Collagen binding proteins in osteoclasts." Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265344.

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4

Herrera, Bruno Schneider. "Óxido nítrico e periodontite experimental: caracterização de mediadores intracelulares da atividade osteoclastogênica, conseqüências locais e sistêmicas." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-11092008-154717/.

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A doença periodontal é a doença crônica mais prevalente nas doenças orais. Dentre os mediadores desse processo contam-se a Resolvina E1 (RvE1), um mediador pró-resolução da inflamação capaz de diminuir a perda óssea secundária á doença periodontal em coelhos, e o oxido nítrico (NO), o qual pode ser produzido em grandes quantidades pela ação de citocinas e estimular a diferenciação e atividade osteoclástica. O objetivo deste estudo foi investigar os efeitos da RvE1 em osteoclastos (OCs) em cultura e os mecanismos envolvidos, bem como o papel do NO na progressão da periodontite experimental em r

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5

Franco, Gilson Cesar Nobre. "Analise da farmacocinetica e dos indices PK/PD da doxiciclina no plasma, fluido gengival e saliva e avaliação de seu efeito sobre a osteoclastogenese mediada por RANKL." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288516.

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Orientadores: Pedro Luiz Rosalen, Francisco Carlos Groppo, Toshihisa Kawai<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-08T05:44:44Z (GMT). No. of bitstreams: 1 Franco_GilsonCesarNobre_D.pdf: 2005090 bytes, checksum: e5ea5ec57b82c8e2fa17e200ad139928 (MD5) Previous issue date: 2007<br>Resumo: Doxiciclina (Dox) é um antimicrobiano pertencente à família das tetraciclinas com um amplo espectro de ação contra bactérias Gram-positivas e Gram-negativas. Além de suas propriedades antimicrobianas, Dox é atualmen

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6

Cayana, Ezymar Gomes. "Efeito da administração intermitente do PTH (1-34) na periodontite experimental em ratas expostas à fumaça de cigarros." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290845.

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Orientadores: Enilson Antônio Sallum, João Baptista César Neto<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-16T09:18:22Z (GMT). No. of bitstreams: 1 Cayana_EzymarGomes_D.pdf: 2999544 bytes, checksum: 87318d3714c0dada68775562aa703c38 (MD5) Previous issue date: 2010<br>Resumo: O objetivo deste estudo foi investigar histológica e histoquimicamente a influência da inalação da fumaça de cigarros (IFC) e da administração intermitente de PTH 1-34 sobre a perda óssea alveolar na região de furca em ratas submeti

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7

Taylor, Adam. "The role of Rab GTPases in osteoclasts." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=59017.

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8

Hussein, Osama. "Interaction of breast cancer cells with osteoclasts." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103695.

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Breast cancer is a major health problem. Metastatic disease is generally incurable. In the majority of patients, the skeleton bears the major metastatic burden. Bony lesions of metastatic breast cancer are usually osteolytic. Osteolytic metastases are formed by the pathological activation of osteoclasts. Anti-osteoclastic drugs are standard of care for patients suffering from breast cancer metastases. We conducted this project to decipher the signalling mechanisms responsible for osteoclasts activation in response to exposure to mediators released from mammary carcinoma cells. We evaluated the

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9

Gray, A. "Isolation, generation and characterization of equine osteoclasts." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599624.

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a) Equine osteoclasts (OCs) were identified in <I>ex vivo</I> samples of developing long bone. They were particularly numerous in areas of active bone formation and remodelling such as at the longitudinal septum between cartilage and subchondral bone and in the spongiosum. Equine OCs were identified as being typically multinuclear and expressing very high levels of tartrate resistant acid phosphatase (TRAP) and cathepsin K. Only low levels of cathepsin B were detected in equine OCs. b) Techniques were developed to isolate equine OCs for the first time <I>in vitro</I>. The phenotype of these ce

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10

Ford, Lorna. "An investigation into the effects of endocannabinoids and the COX-2 metabolite of 2-Arachidonyl glycerol on bone cells." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=33596.

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11

Tan, Jamie We-Yin. "The investigation of RANKL TNF-like core domain by truncation mutation." University of Western Australia. School of Surgery and Pathology, 2003. http://theses.library.uwa.edu.au/adt-WU2004.0032.

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Osteoclasts are multinucleated cells found exclusively in bone and are derived from the haematopoietic cells of monocytes/macrophage lineage. The cell-to-cell interaction between osteoblastic/stromal cells and osteoclast precursor cells is necessary for osteoclastogenesis. Receptor Activator of NF-κB ligand (RANKL) was identified as a membrane-bound TNF ligand family member that is the ‘master’ cytokine expressed on osteoblastic/stromal cells, which stimulate osteoclastogenesis through cell-to-cell contact with osteoclast precursors. RANKL is considered to be a factor that is necessary and suf

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12

Pitombo, Jonleno Coutinho Paiva [UNESP]. "Impacto de andrógenos na diferenciação e atividade de osteoclastos em cultura celular." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/138870.

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Submitted by JONLENO COUTINHO PAIVA PITOMBO null (jomtombo@hotmail.com) on 2016-05-23T15:01:17Z No. of bitstreams: 1 Jonleno Coutinho P Pitombo.pdf: 2907326 bytes, checksum: b153a02592cf15ac920e757f91e472b8 (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-05-25T16:58:23Z (GMT) No. of bitstreams: 1 pitombo_jcp_me_arafo.pdf: 2907326 bytes, checksum: b153a02592cf15ac920e757f91e472b8 (MD5)<br>Made available in DSpace on 2016-05-25T16:58:23Z (GMT). No. of bitstreams: 1 pitombo_jcp_me_arafo.pdf: 2907326 bytes, checksum: b153a02592cf15ac920e757

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13

Wang, Cathy Ting-Peng. "Molecular dissection of RANKL signaling pathways in osteoclasts." University of Western Australia. School of Surgery and Pathology, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0037.

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[Truncated abstract] Bone remodeling is intricately regulated by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The elevation in osteoclast number and/or activity is a major hallmark of several common pathological bone disorders including post-menopausal osteoporosis, osteoarthritis, Paget's disease, and tumour-mediated osteolysis. Receptor activator of nuclear factor kappa B ligand (RANKL) is a key cytokine for osteoclast differentiation and activation. The association of RANKL to its cognate receptor, RANK, which is expressed on osteoclast precursors and mature o

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14

Luukkonen, J. (Jani). "Osteopontin and osteoclasts in rheumatoid arthritis and osteoarthritis." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526223643.

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Abstract Rheumatoid arthritis and osteoarthritis are two chronic joint diseases, which cause two of the largest socioeconomical burdens among all joint diseases according to the World Health Organization. Both diseases are associated with changes in bone structure and bone cell, especially osteoclast, function. The etiology or pathogenesis of these diseases are not completely understood. Traditionally, osteoarthritis is seen as a disease resulting from mechanical wear of cartilage and bone, and rheumatoid arthritis as an autoinflammatory disease of synovial tissue. However, also in osteoarthri

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15

Cleaton-Roberts, Melanie. "Development and characterisation of polyclonal and monoclonal antibodies raised against cathepsin K." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250227.

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16

Das, Subhajit. "Study of critical pathways important for the pathophysiology and pharmacology of osteoclasts." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=204054.

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Bone and skeletal joint disorders affect millions of people with significant morbidity and mortality. Over the last few decades it has become apparent that the physiological structure of bone is maintained by the balanced functioning of bone-forming osteoblast and bone-resorbing osteoclast cells. Thus study of the regulation and function of osteoclasts became the focus of scientific research to find therapeutic targets for bone related disorders. The aim of this study was to elucidate the roles of two pathways, namely Receptor Activator of NFB (RANK) signaling pathway and mevalonate pathway i

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17

Hocking, Lynne J. "Genetics of Paget's disease of bone." Thesis, University of Aberdeen, 2002. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU160239.

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In Chapter 4, I investigated the roles of the RANK signalling partners RANK ligand (RANKL) and osteoprotegerin (OPG) in the pathogenesis of sporadic and familial PDB. One polymorphism in the RANK gene and five polymorphisms in the OPG gene were examined in sporadic PDB cases and in sex- and age-matched controls. No allele-disease or genotype-disease association was observed for the <i>RANKL </i>polymorphism, suggesting RANKL is not directly involved in susceptibility to sporadic PDB. Genotypes at two <i>OPG</i> polymorphisms did significantly predict disease status in individuals affected with

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18

Buitrago, Liseth Yamile Wilches. "Papel da frutose 1,6-bisfosfato na osteoclastogênese e reabsorção óssea in vitro." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-23042018-120322/.

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O remodelamento ósseo é um processo metabólico, dentro do qual os osteoblastos e os osteoclastos, participam ativamente. Portanto, qualquer alteração neste equilíbrio, pode provocar uma modificação na densidade mineral do osso, situação observada em certas doenças osteolíticas como osteoporose, artrite reumatóide e periodontite. Nos últimos anos, há um crescente interesse em avaliar o papel da glicólise na proliferação, sobrevivência e diferenciação dos diferentes tipos celulares. Em particular, tem sido evidenciado o efeito regulador da frutose 1,6-bisfosfato (FBP), um intermediário da via gl

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19

Magalhães, Fernando Augusto Cintra. "Efeito protetor da Interleucina-4 na reabsorção óssea periodontal induzida por agonista de TLR2 (Pam2CSK4) /." Araraquara, 2018. http://hdl.handle.net/11449/154085.

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Orientador: Pedro Paulo Chaves de Souza<br>Resumo: A periodontite é resultado do desequilíbrio entre o biofilme bacteriano e a resposta imune do hospedeiro. Componentes bacterianos, como o lipopolissacarídeo (LPS) e as lipoproteínas, são reconhecidos pelo sistema imune e desencadeiam a produção de citocinas que auxiliam no combate à infecção, mas também induzem a destruição tecidual. A participação do LPS na destruição óssea já é bem estabelecida, porém o papel das lipoproteínas na periodontite permanece carente de investigação. Na periodontite, citocinas pró-inflamatórias participam do proces

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20

Wilkinson, Debbie Isabelle. "Visualisation of osteoclast membrane domains." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158808.

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Osteoclasts polarise upon activation and form four distinct membrane domains; the basolateral domain, the sealing zone, the functional secretory domain and the ruffled border. The ruffled border is the resorptive organelle of the cell and provides a large surface area for the release of protons and enzymes into the space beneath the osteoclast. Defects in osteoclast formation or function can lead to diseases such as osteopetrosis. Ruffled border formation is a critical event in osteoclast function but the process by which it and other membrane domains form is only partially understood. Vesicul

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21

Mancini, Lucia. "Nitric oxide regulation of bone metabolism." Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343902.

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22

Mellis, David. "The study of RANK mutations associated with the diseases of osteoclast dysfunction." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=166647.

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Osteoclasts are the cells that resorb bone to maintain a healthy skeleton. Receptor activator of NFkB (RANK) is a receptor that is critical for the formation, activity and survival of osteoclasts. A number of mutations have been identified within RANK that cause bone diseases with opposite osteoclast phenotypes. The aim of this thesis was to study the downstream consequences of these disease-associated mutations for RANK protein processing and activation of the RANK signalling pathway. Early onset Paget’s disease of bone (ePDB), Familial Expansile Osteolysis (FEO) and Expansile Skeletal Hyperp

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23

Gu, Yuchun. "Investigation of ion channels on bone cells." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369360.

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24

Wang, Wen. "Investigating the role of CCN1, CCN2, and CCN6 in osteoclast and osteoblast physiology." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=204059.

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CCN protein family members (CYR61, CTGF, Nov, Wisp-1, Wisp-2 and Wisp-3) have important roles in many different processes including angiogenesis, inflammation, remodelling of extracellular matrix and tumorigenesis. In bone, CCN1 increases osteoblastogenesis via Wnt3A signalling and activation of -catenin which, in turn, upregulates CCN1 expression. The exact role of CCN1, CCN2, and CCN6 in osteoclast physiology are not known but we have recently shown that recombinant human (rh)CCN1 inhibits osteoclastogenesis in vitro. The aim of this study was to determine: 1) the expressions of all six mem

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25

Tran, Anh Nhi. "Examining the role of autophagy in osteoclast function." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238273.

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Osteoclasts are cells that degrade bone, by forming a ruffled border (RB) membrane, contained within an actin-rich attachment site (the sealing zone; SZ). Lysosomal vesicles fuse to the RB, and release their contents into the extracellular space to degrade bone matrix. LC3, a marker of autophagosomes, localises to the RB, implying that either canonical autophagy (i.e. autophagosomes) or non-canonical autophagy (a process where LC3 localises to non-autophagic membrane) is involved in the resorptive function of osteoclasts. To examine this in detail, this study used a model with reduced canonica

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26

Ek-Rylander, Barbro. "Studies on the structure and function of the purple acid phosphatase of rat osteoclasts." Stockholm : Dept. of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, 1995. http://catalog.hathitrust.org/api/volumes/oclc/33858972.html.

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27

Pitombo, Jonleno Coutinho Paiva. "Impacto de andrógenos na diferenciação e atividade de osteoclastos em cultura celular /." Araraquara, 2016. http://hdl.handle.net/11449/138870.

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Orientador: Luis Carlos Spolidorio<br>Banca: Ticiana Sidorenko de Oliveira Capone<br>Banca: Thallita Pereira Queiroz<br>Resumo: Os mecanismos de ação dos andrógenos sobre homeostase e regulação das células que participam do turnover ósseo em fêmeas ainda são pouco compreendidos. Este trabalho teve como principal objetivo avaliar a participação de andrógenos na diferenciação e atividade de osteoclastos in vitro. Células totais de medula óssea de fêmur e tíbia de camundongos fêmeas foram utilizadas como fonte de células precursoras de osteoclastos, sendo cultivadas utilizando-se α-MEM suplementa

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28

Hu, Rong. "Regulation of osteoclast differentiation by transcription factors MITF, PU.1 and EOS." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1166644761.

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29

Napimoga, Marcelo Henrique. "Indução de osteoclastogene independente de RANK por uma fração lipidica isolada de Porphyromonas gingivalis." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288635.

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Orientador: Reginaldo Bruno Gonçalves<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-05T08:24:42Z (GMT). No. of bitstreams: 1 Napimoga_MarceloHenrique_D.pdf: 980827 bytes, checksum: d6e89bf1b359918d8c502f0a7367d2c1 (MD5) Previous issue date: 2005<br>Resumo: Porphyromonas gingivalis (Pg) sintetiza diversas classes de fosfolipídeos. Entretanto, pouco se sabe sobre os efeitos biológicos que estes lipídeos exercem sobre a reabsorção óssea. Células precursoras de osteoclastos de camundongos, incluindo RAW264.7

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30

Marques, Marcelo Rocha 1976. "Avaliação do efeito do PTH nas citocinas IL-1beta, IL-6, TNF-alfa, nas metaloproteinases da matriz 2 e 9, e na atividade osteoclastica em ratos com periodontite induzida." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290043.

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Orientador: Silvana Pereira Barros<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-11T01:50:55Z (GMT). No. of bitstreams: 1 Marques_MarceloRocha_D.pdf: 1159258 bytes, checksum: b480791f2296297d8bf75042e1af33c1 (MD5) Previous issue date: 2007<br>Resumo: O hormônio paratireóideo (PTH), um mediador da remodelação óssea, é o principal regulador da homeostasia do cálcio, sendo capaz de promover reabsorção e aposição ósseas. Em trabalhos realizados recentemente, foi verificado que o tratamento com PTH, administr

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31

Bighetti, Bruna Barros. "Avaliação das citocinas TNF-α, RANKL e OPG e do número de osteoclastos no reparo de defeito ósseo em calvária de ratos diabéticos tratados com matriz óssea desmineralizada." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-25112016-114638/.

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Neste trabalho, foi avaliado a participação dos osteoclastos bem como a ação das citocinas RANKL, OPG e TNF-α durante a formação e remodelação óssea em defeitos ósseos de tamanho crítico em ratos normoglicêmicos e diabéticos tratados ou não com a MAOD. Para isso, foram utilizados 250 ratos machos Wistar. Trinta ratos foram utilizados para coleta dos fêmures e tíbias, os quais foram processados para obtenção da MAOD. Os demais 220 ratos foram divididos em Grupo Não Diabétido (CTL, n=110) e Grupo Diabético (DIAB, n= 110) induzido pela aplicação de uma dose única de 47 mg/Kg de massa corpor

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Yamamoto, Fernanda Paula. "Estudo da presença de osteonecrose na madíbula após exodontia de molares em ratos tratados com alendronato de sódio." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-09112010-111814/.

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A osteonecrose dos ossos maxilares relacionada ao uso prolongado de bisfosfonatos (OMRB), associada a procedimentos cirúrgicos, constitui uma entidade com menos de dez anos de ocorrência na clínica estomatológica. Os bisfosfonatos (BFs) são medicamentos antireabsortivos altamente efetivos no tratamento de diversas doenças ósseas, além de metástases. Embora a maioria dos casos de OMRB tenha sido relatada após o uso de potentes BFs da terceira geração, o alendronato de sódio (ALN), um bisfosfonato de segunda geração, é amplamente utilizado no tratamento e prevenção de doenças ósseas. O presente

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33

Shaikh, Atik Badshah. "Role of CKIP-1 in suppression of osteoblast mediated bone repair in a collagen induced non-human primate arthritis model." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/478.

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Rheumatoid arthritis (RA) is a systemic, inflammatory disease, which predominantly affects multiple joints. RA is characterized by swollen joints and peri-articular bone erosion. Conventional RA treatments have shown to reduce inflammation and slow down bone erosion, but repair of bone erosion is limited. Additionally, failure to repair for bone erosion in rheumatoid arthritis (RA) is caused by inadequate osteoblast-mediated bone formation resulting from focal inflammatory environment. Hence, there is immediate need to facilitate greater insight and develop a new therapeutic strategy to aid os

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34

Buckley, Katherine Anne. "The effects of extracellular nucleotides and parathyroid hormone on bone remodelling." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366663.

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Osteoclasts are multinucleated, terminally differentiated cells found in bone tissue, which have the unique ability to resorb calcified substrates. The study of human osteoclasts has been restricted in the past due to difficulties in obtaining these cells. Recently, however, cell culture techniques have been devised that allow human osteoclasts to be grown in culture from their mononuclear precursors found in peripheral blood, therefore providing a constant supply of these cells. These cultures are based on the discovery of RANKL (receptor activator for NFJ(B ligand), which has recently been s

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35

Bord, Sharyn. "The role of matrix metalloproteinases in human bone modelling and remodelling." Thesis, Anglia Ruskin University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243631.

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36

Midha, Swati. "Osteogenesis in porous biomaterials for bone regeneration." Thesis, Ulster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674920.

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37

Gartland, Alison. "The role of the P2X7 receptor in bone cell formation." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343968.

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38

Neale, Susan Dorothy. "The role of macrophages in pathological bone resorption /." Title page, table of contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09MSM/09msmn348.pdf.

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39

Waring-Green, Victoria. "Characterisation of a novel antigen found in osteoclasts and tumour cells." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526832.

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40

Williams, Allan James. "Thyroid hormone and thyroid stimulating hormone actions in osteoblasts and osteoclasts." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497252.

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41

Hoflack, Bernard, Pierre Jurdic, Thilo Riedl, Anne Gallois, and Maria Arantzazu Sanchez-Fernandez. "Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184120.

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BACKGROUND: Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation. It is currently unclear whether osteoclasts can influence bone rebuilding. METHODOLOGY/PRINCIPAL FINDINGS: Using in vitro cell systems, we show here that mature osteoclasts, but not their precursors, secrete chemotactic factors recognized by both mature osteoblasts and their precursors. Several growth factors whose expression is upr

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42

Hoflack, Bernard, Pierre Jurdic, Thilo Riedl, Anne Gallois, and Maria Arantzazu Sanchez-Fernandez. "Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling." PLOS one, 2008. https://tud.qucosa.de/id/qucosa%3A28994.

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BACKGROUND: Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation. It is currently unclear whether osteoclasts can influence bone rebuilding. METHODOLOGY/PRINCIPAL FINDINGS: Using in vitro cell systems, we show here that mature osteoclasts, but not their precursors, secrete chemotactic factors recognized by both mature osteoblasts and their precursors. Several growth factors whose expression is upr

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43

Hu, Shiqiong. "Mechanics and Dynamics of Cell Adhesion : Experimental Study of the Osteoclasts." Lyon, Ecole normale supérieure, 2010. http://www.theses.fr/2010ENSL0594.

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Osteoclasts are large, multinucleated cells, which resorb mineralized bone. When an osteoclast encounters a substrate, dot-like actin-rich structures, the podosomes, appear and assemble into clusters, rings or a belt. We experimentally investigate, from a cell population to a single podosome, their function and dynamics. Over a cell population, kinetic measurements show that the cell surface area A scales as A ~ K2, where K is the number of nuclei, indicating a flat morphology. By defining quantities that account for the spatial distribution of the actin within the cell, we demonstrate that th

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44

Hollberg, Karin. "Studies on the phenotype and function of osteoclasts using osteopetrotic and rachitic animal models /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-313-9/.

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45

Fernandes, Leandro Araújo [UNESP]. "Ação da terapia fotodinâmica no tratamento da doença periodontal experimentalmente induzida em ratos tratados ou não com nicotina: estudo histológico, histométrico e imunoistoquímico." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/104707.

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Made available in DSpace on 2014-06-11T19:33:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-11-24Bitstream added on 2014-06-13T19:04:20Z : No. of bitstreams: 1 fernandes_la_dr_araca.pdf: 1070170 bytes, checksum: 5b88fec778e5c29fd6d418138e92a16f (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O objetivo do presente estudo foi avaliar a influência da terapia fotodinâmica (PDT) como coadjuvante ao tratamento não cirúrgico da doença periodontal (DP) experimentalmente induzida em ratos trat

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46

Muguruma, Yukari. "The origin and differentiation of the osteoclast /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/5681.

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47

Alkindi, Mohammed. "Effects of soluble factors released by oral squamos cell carcinoma on osteoclasts." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103726.

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Objective: Bone invasion represent significant problem in managing head and neck cancers, however the mechanisms of interactions between oral squamous cell carcinoma (OSCC) and bone cells are poorly understood. We hypothesized that tumor cells can directly stimulate osteoclastogenesis. Methods: OSCC cell lines, bone-invasive BHY and metastatic but not bone-invasive HN were cultured and conditioned medium (CM) was collected. Osteoclast formation from RAW 264.7 mouse monocytic cell-line was assessed. Results: When RAW 264.7 were primed with receptor activator of nuclear factor κB ligand (RANKL)

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48

Lymperi, Stefania. "The role of osteoblasts and osteoclasts in the haemopoietic stem cell niche." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501195.

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49

Quang, Jonathan Q. "Bone marrow stromal cell proliferation in mice lacking NFATc1 in mature osteoclasts." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12195.

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Thesis (M.A.)--Boston University<br>The transcription factor Nuclear factor of activated T cells c1 (NFATc1) is a master regulator of osteoclastogenesis. Previous knockout studies have shown that global NFATc1 deletion in younger mice leads to poor osteoclastogenesis and osteopetrosis. Here we show that the cathepsin k-cre mediated deletion of NFATc1 in mature osteoclasts leads to a phenotype with notable differences including the presence of abnormally large, multinucleate, TRAP-positive osteoclasts and the effacement of the bone marrow by stromal cells resembling a fibrotic reaction. We char

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McDermott, Emma. "Characterisation of the osteoclast ruffled border using advanced imaging techniques." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=236980.

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The osteoclast ruffled border is a highly convoluted, complex membrane that is necessary for bone resorption. It is thought to form following mass lysosomal fusion with the boneapposing plasma membrane and vesicular trafficking is vital for its formation and function. The aim of this PhD was to better understand the ultrastructure, formation and function of the ruffled border using TEM and advanced imaging techniques. Ruffled border reformation following calcitonin treatment was visualised and the stages of ruffled border formation were described. Ruffled borders in healthy and osteopetrotic o

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