Literatura científica selecionada sobre o tema "Ontario Manufacturers' Association"

This study examines the results of a survey of 1,000 Canadian internal combustion engine (ICE) vehicle owners to assess factors that would encourage them to purchase an electric vehicle (EV). Further to the work of Peters and Dutschke (2014) and (Matthews et al. (2017) we combine the various drivers of EV adoption, independently identified in the literature, into one model in order to investigate their influence on the intent to purchase an EV. Through correlations and a series of probit regression modelling, we provide evidence to support additional policies that could establish greater relative advantages for owning an EV. These include the promotion of the communication of those advantages through experiential awareness initiatives such as improved access to EV test drives and consumer information. We suggest that car dealerships are important partners in this journey and their association is critical for greater diffusion of EVs in the market. Our findings have implications for EV manufacturers and government policy makers.

The importance of mobility in Canada’s history can hardly be overstated. The built waterways, railways, and roadways that allowed for the movement of peoples, goods, and ideas within the country have long been considered cultural icons conveying collective ideas of Canadian identity. Yet, little has been written on the history of the modern construction machines that made this mobility infrastructure possible after Confederation, along with their designers, manufacturers, and operators. This article helps fill that gap by examining the technological development, manufacturing, and commercialization of earthmoving equipment in Canada (especially Ontario) in the 1860s–1920s, a period of great construction activity, including two of the world’s largest civil engineering and earthmoving projects and one of the fastest-expanding road networks in North America. It discusses the role of the federal, provincial, and municipal governments in developing, adopting, and disseminating this technology, and their ultimate reliance on American manufacturers despite the National Policy’s protectionism. This article supports the argument that technological development in Canada during the Second Industrial Revolution was continentally integrated in ways that involved technological dialogue with American companies, associations, and publications. While this manufacturing sector became dominated by American corporations by the First World War, the extent to and manner by which that happened varied depending on the type of machinery and the construction sectors in which they were used. The technological transition from steam-powered machines to electric, gasoline, and diesel motors and how it impacted Canadian manufacturers are also discussed.

13 Background: According to USP 797 and the National Association of Pharmacy Regulatory Authorities standards, the Beyond Use Date (BUD) based on sterility for single-dose vials is 6 hours, after which the contents must be discarded. In Ontario, centres have traditionally based BUD on stability data, not sterility data. This change presents concern about potential drug waste so an analysis was done to estimate the financial impact to the 76 systemic treatment facilities in Ontario. Methods: Using an administrative database that records the daily total dose of drugs administered by facility, annual drug waste cost was calculated using daily dose administered, cost per milligram, and available vial size(s) for 26 publicly funded drugs. Two different methods were used to determine the amount of drug waste. Method 1 used the largest vial size matched to the closest amount of drug required. Method 2 used the optimal vial size mix, when there are multiple vial sizes, to minimize wastage across all configurations of vial size. Some assumptions made include: 1) each facility had access to all available vial sizes, and 2) single-dose vial contents were true to the stated quantity as per the manufacturer. Results: The 10 facilities with the highest waste estimates are summarized in the table. The total waste estimates for all facilities are $25,927,861 (method 1) and $12,945,353 (method 2). Waste estimates were also calculated by drug, with rituximab, bevacizumab and pemetrexed having the highest waste costs. These drugs are only available in vials with a large range in size (100 and 500 mg), but could waste more than drugs with more size options or less variance between sizes. Conclusions: Assigning a BUD based on 6 hour sterility standards will have significant financial implications to facilities in Ontario. Development of mitigation strategies should be explored to provide guidance to Ontario and other jurisdictions on how to curtail the budget impact.[Table: see text]

Abstract Background Polymorphisms in mitochondrial DNA can be used to group individuals into haplogroups that reflect human global migration. These mitochondrial variants are associated with differences in mitochondrial function and have been associated with multiple diseases, including cancer. In this analysis, we evaluated the association between mtDNA haplogroup and risk of myelodysplastic syndromes (MDS). Methods Cases were identified by rapid case ascertainment through the population-based Minnesota Cancer Surveillance System (MCSS). Participants were recruited to the MDS study if they were diagnosed with MDS between April 1, 2010 and October 31, 2014. Eligibility criteria included residence in Minnesota, age at diagnosis between 20 and 85 years, and ability to understand English or Spanish. Centralized pathology and cytogenetics review were conducted to confirm diagnosis and classify by subtypes. Controls were identified through the Minnesota State driver's license/identification card list. Genomic DNA from cases and controls was collected using Oragene DNA collection kits (DNA Genotek, Ontario, Canada) and extracted via Autopure LS Instrument according to manufacturer's instructions (Qiagen). We genotyped 15 mtSNPs that capture common European mitochondrial haplogroup variation (Mitchell et al Hum Genet 2014; Raby et al J Allergy Clin Immunol 2007) on the Sequenom iPLEX Gold MassArray platform (Sequenom, Inc., San Diego, CA) in the University of Minnesota Genomics Core. Because haplogroup frequencies vary by race and ethnicity, we restricted analyses to non-Hispanic white cases and controls. All statistical analyses were conducted using SAS v.9.3 (SAS Institute, Cary, NC). Odds ratios (OR) and 95% confidence intervals (CI) were calculated. We also evaluated associations by MDS subtype and IPSS-R risk category. Results We were able to classify 215 cases with confirmed MDS and 522 controls into one of the 11 common European haplogroups. The distribution of haplogroups in our control sample was similar to the distribution reported in a previous sample of non-Hispanic white individuals from the United States (Mitchell et al Hum Genet 2014), with the highest number in the H haplogroup (42%). Due to small sample sizes in some subgroups, we combined mt haplogroups into larger bins based on the haplogroup evolutionary tree, including HV (H+V), JT (J+T), IWX (I+W+X), UK (U+K), and Z (van Oven & Kayser Hum Mut 2009) for comparisons of cases and controls. Using haplogroup HV as the reference group, we found a statistically significant association between haplogroup JT and MDS (OR=0.57, 95% CI 0.36, 0.90, p=0.02). No other significant associations were observed in a comparison of cases and controls (Figure). In the analysis stratified by MDS subtype, the association with haplogroup JT reached statistical significance only in MDS cases with the RCMD subtype (OR=0.42, 95% CI 0.18, 0.97), although the association was similar in magnitude for RARS and the p-value for heterogeneity was non-significant (0.76). Similarly, the associations between haplogroup JT and MDS were similar in the analysis stratified by IPSS-R risk category (p-value for heterogeneity = 0.71). Conclusions In this population-based study of MDS, we observed an association between mtDNA haplogroup JT and risk of MDS. Previous studies using cybrid cells have reported functional differences by mtDNA haplogroup and provide biological plausibility for the observed association, including higher capacity to cope with oxidative stress in haplogroup T (Meuller et al PLoS One 2012) and lower levels of ATP and reactive oxygen species production in haplogroup J (Kenney et al PLoS One 2013). Further studies of the relationship between mtDNA variation and MDS are warranted in larger sample sizes. Figure 1. Association between mtDNA haplogroup and MDS Figure 1. Association between mtDNA haplogroup and MDS Disclosures No relevant conflicts of interest to declare.

Recent reexamination of pottery, copper objects, and glass trade beads using modern analytic methods has amended the occupational history of the Cloudman site (20CH6), once interpreted as an early “Contact” period site in Michigan. The original chronology of the site, located on northern Michigan's Drummond Island in Lake Huron, was based on an apparent association of Iroquoian pottery with European-made trade goods relatively dated to circa AD 1630. Current advances in archaeological dating methods have revealed new insights into the poorly understood settlement patterns and social interactions of various Upper Great Lakes groups between AD 1300 and 1700. Accelerator mass spectrometry dating of carbonized food residue collected from late Late Woodland and Ontario Iroquoian pottery vessels suggests some contemporaneous use of both styles and the culmination of occupation by pottery-making groups by AD 1500. Elemental analysis of glass beads indicates that the recovered trade items were likely manufactured post–AD 1650. Likewise, compositional analysis of copper-base metal artifacts clarifies how such objects were made and used over time at the site. The results demonstrate how the application of modern analytic methods to curated collections can lead to significant reinterpretation, ultimately enhancing understandings of regional chronologies, social relationships, and population movements.

Abstract Background Reprocessing of nasopharyngoscopes represents a large financial burden to community physicians. The aim of this study was to perform a cost analysis of nasopharyngoscope reprocessing methods at the community level. Methods Electronic surveys were distributed by email to community otolaryngologists. Surveys were comprised of 14 questions assessing clinic size, nasopharyngoscope volume, scope reprocessing method and maintenance. Four manual techniques were evaluated: (1) soak with ortho-phthalaldehyde solution (Cidex-OPA; Advanced Sterilization Products, Johnson and Johnson Inc., Markham, Canada), (2) soak with accelerated hydrogen peroxide solution (Revital-Ox; Steris Canada Inc., Mississauga, Canada), (3) disinfection with chlorine dioxide wipe (Tristel Trio Wipes System; Tristel plc., Cambridgeshire, UK), (4) UV-C light system (UV Smart, Delft, The Netherlands). All costs are reported in CAD, and consumable and capital costs for reprocessing methods were obtained from reported vendor prices. Time costs were derived from manufacturer recommendations, the Ontario Medical Association Physician’s Guide to Uninsured Services, and the Ontario Nurses Association Collective Agreement. Cost analyses determined the most cost-effective reprocessing method in the community setting. Sensitivity analyses assessed the impact of reprocessing volume and labour costs. Results Thirty-six (86%) otolaryngologists responded and answered the survey. The cost per reprocessing event for Cidex-OPA, Revital-Ox, Tristel and UV system were $38.59, $26.47, $30.53, and $22.74 respectively when physicians reprocessed their endoscopes themselves. Sensitivity analyses demonstrated that Revital-Ox was the least costly option in a low volume, however, the UV system remained the most cost effective in higher volumes. The cost per reprocessing event when done by clinic staff was $5.51, $4.42, $11.23 and $6.21 for Cidex-OPA, Revital-Ox, Tristel and the UV system. Conclusions The UV light system appears to be the most cost-effective method in high volumes of reprocessing, and Revital-Ox is cheaper in lower volumes and when performed by clinic staff rather than physicians. It is important to consider the anticipated work volume, shared clinic space and number of co-workers prior to choosing a reprocessing method. Graphical Abstract

Background: Direct-acting oral anticoagulant (DOAC) use is increasing in Canada. This study evaluated nurse, staff physician, and resident physician understanding of DOAC dosing and administration.Methods: An electronic survey was distributed to health care providers (HCPs) at a hospital in Ontario, Canada. The questions discussed oral anticoagulant indications, dose adjustments, storage and administration, and counselling.Results: A total of 52 responses were received: 3 from nurses, 1 from a nurse practitioner, 21 from staff physicians (Hematology, Thrombosis Medicine, General Internal Medicine, Neurology), 25 from resident physicians, and 2 unspecified respondents. Twenty-four respondents (46%) felt comfortable or very comfortable prescribing DOACs. Only 15 (29%) knew that dabigatran should not be exposed to moisture and 13 (25%) knew that higher doses of rivaroxaban should be taken with food.Conclusion: HCP understanding of DOACs is variable. Though they express comfort with DOACs, their self-reported knowledge of dosing, administration, and patient counselling is incomplete.RésuméContexte : L’utilisation d’anticoagulants oraux directs (AOD) est en hausse au Canada. La présente étude évalue la connaissance qu’ont les infirmières et les médecins (membres du personnel et résidents) de l’administration et du dosage des AOD.Méthodologie: Un sondage en ligne a été effectué auprès des fournisseurs de soins de santé (FSS) d’un hôpital en Ontario, Canada. Les questions portaient sur les indications, l’adaptation posologique, l’entreposage et l’administration des anticoagulants oraux, ainsi que la démarche de conseil au patient.Résultats: Les 52 répondants se répartissent ainsi : 3 infirmières; 1 infirmière praticienne; 25 médecins membres du personnel (hématologie, thrombose, médecine interne générale et neurologie); 25 médecins résidents. Deux répondants n’ont pas précisé leur statut. Vingt-quatre répondants (46 %) se sentent à l’aise ou très à l’aise de prescrire des AOD. Seulement 15 répondants (29 %) savaient que le dabigatran ne doit pas être exposé à l’humidité et 13 (25 %) savaient que les doses plus élevées de rivaroxaban devaient être prises avec de la nourriture.Conclusions : La connaissance qu’ont les FSS des AOD est variable. Les FSS se disent à l’aise de travailler avec les AOD, mais, d’après ce qu’ils rapportent, leur savoir en matière de dosage, d’administration et de conseil au patient comporte des lacunes.In recent years, an increasing number of direct oral anticoagulants (DOACs) have become available. DOACs appear to be effective, safe, and convenient alternatives to warfarin.1–8 The 4 available DOACs in Canada are dabigatran, apixaban, rivaroxaban, and edoxaban and are approved by Health Canada for the prevention of stroke and systemic embolism in patients with atrial fibrillation and for treatment and secondary prevention of venous thromboembolism (VTE).DOACs come with specific recommendations for storage and administration. Dabigatran should not be exposed to moisture as this results in its breakdown and loss of potency.9,10 Moreover, dabigatran should be taken as a whole capsule, and not crushed or chewed. Modifying the capsule can lead to increased absorption and potentially increased risk of bleeding.9 Rivaroxaban at higher doses should be administered with food.10 If it is taken when fasting, its bioavailability is reduced by one third, thereby resulting in potentially increased risk of thrombosis.11Given that laboratory monitoring of DOACs is not routinely performed, it is crucial to ensure that these medications are administrated according to manufacturer’s recommendations. It is unclear whether DOACs are appropriately prescribed for indications currently approved by Health Canada, and whether patients are advised on optimal administration. Ideally, HCPs should counsel patients about appropriate DOAC use, however their understanding of this issue is unknown. To determine the level of understanding of administration and indications for DOACs, we conducted a cross-sectional study of HCPs at a Canadian hospital using a survey questionnaire.MethodsStudy PopulationAn electronic questionnaire examining HCP understanding of oral anticoagulant indications, dosing, administration, storage was distributed to physicians in different specialties, nurses, and nurse practitioners. The physician groups included: hematologists, thrombosis specialists, neurologists, internists, and resident physicians.Data CollectionThe electronic questionnaire was sent via email. Data collected included demographics, understanding of oral anticoagulant: (1) indications; (2) dosing and dose-adjustment based on renal function and age; (3) storage; and (4) administration. Additional data was collected about how HCPs counsel patients and how often they prescribe oral anticoagulants. Questionnaires were completed anonymously and no identifying data was collected outside of the participant’s occupation. Participation in this survey was voluntary. This study was approved by the Hamilton Integrated Research Ethics Board.Statistical AnalysisDescriptive statistics was used to identify the proportion of HCPs with understanding of appropriate oral anticoagulant indication, dosing, and dose-adjustment based on age and renal function. HCPs’ comfort level with prescribing oral anticoagulants, and the frequency with which they prescribe oral anticoagulants, was also assessed using descriptive statistics.ResultsParticipant CharacteristicsThe survey was sent to 300 potential respondents and 52 responses were received: 3 from nurses, 1 from a nurse practitioner, 21 from staff physicians, 25 from resident physicians, and 2 did not specify their profession. The speciality of the staff physicians included: 10 General Internal Medicine; 5 Neurology; 5 Thrombosis; and 1 Hematology. Twenty-two of the 25 residents were from Internal Medicine and 3 were from Neurology. Respondents had a mean of 11.8 years of experience and median of 5.5 years of experience in their field, respectively.HCPs’ Knowledge Base about Oral AnticoagulantsOnly 10% of the respondents correctly identified the approved indications for all 3 DOACs available in Canada. Only 15 (29%) knew that dabigatran should not be exposed to moisture and 27 (52%) knew that it should not be crushed. Thirteen participants (25%) knew that higher doses of rivaroxaban should be taken with food. Forty-three of the participants (83%), 38 (73%), and 42 (81%) adjusted the dose of dabigatran, rivaroxaban, and apixaban, respectively, for renal function. However, only 38 (73%) calculated renal function using the widely accepted Cockcroft-Gault formula. The rest used a laboratory reported e-glomerular filtration rate or creatinine alone. Thirty-one of the respondents (60%) and 29 (56%) adjusted the dose of dabigatran and apixaban, respectively, for age. Additional questions and respondents’ answers regarding dose adjustments are listed in Table 1. Table 1. Questions and Respondent’s Answers Regarding Which Drug(s) Can Be Safety Administered Based on the Renal Function and Age Forty-nine of the respondents (94%) and 27 (52%) correctly responded that the International Normalized Ratio (INR) was elevated in patients on warfarin and rivaroxaban, respectively. However, 22 (42%) and 20 (38%) incorrectly stated that INR was elevated in patients taking dabigatran and apixaban, respectively. Questions and respondents’ answers regarding anticoagulant reversal strategies are listed in Table 2.Table 2. Questions and Respondent’s Answers Regarding which Oral Anticoagulant’s Effect Can Be Reversed Using Each Reversal Agent HCPs’ Comfort Level, Counselling, and Prescription Patterns Twenty-four of the respondents (46%) felt comfortable or very comfortable prescribing DOACs. Twenty of the participants (38%) felt somewhat comfortable, while 5 (10%) felt very uncomfortable, and 3 (6%) did not specify their comfort level. Discomfort with prescribing DOACs was attributed to challenges with reversal of bleeding (31%), lack of knowledge about food or drug interactions (25%), lack of knowledge about appropriate dosing and administration (25%), lack of knowledge about appropriate indications (17%), challenges with dosing in the setting of renal impairment (21%), and bleeding risk (19%).When counselling patients around DOACs: 51 (98%) discussed the indication; 51 (98%) discussed bleeding; 33 (64%) discussed medication administration (e.g., frequency, with or without meals); 36 (69%) discussed drug interactions; 33 (64%) discussed food interactions; and only discussed ways to improve adherence (e.g., use of alarms or calendars). The prescribing pattern of HCPs per month is listed in Table 3. Table 3. How Often Do HCPs Prescribe Each Oral Anticoagulant Each Month DiscussionOur study demonstrates that despite HCPs’ self-expressed comfort with use of DOACs, their knowledge of oral anticoagulant indications, dosing, administration, and storage is suboptimal. HCPs have a unique opportunity to improve patients’ understanding and comfort with medication; it is therefore vital that they have accurate information about oral anticoagulants, and can convey this information effectively to their patients.There is a lack of consensus and a paucity of data around the effect of patient education around oral anticoagulants. A 2013 systematic review evaluating the impact of supplemental patient education on outcomes did not support patient education as a mechanism to improve outcomes. The systematic review’s conclusions were limited by poor quality evidence, and did not include patients on DOACs.12 Subsequent studies have shown that greater patient education about warfarin therapy was associated with better overall anticoagulant control, which might be predictive of better outcomes.13–15 The TREAT randomized trial compared a theory driven intervention using patient interviews, focus groups, educational booklet, self-monitoring diary, and worksheet with usual care. 14 It found that the educational intervention significantly improved anticoagulation control in patients taking warfarin, and concluded that improving patient education is essential to improve the efficacy and safety of anticoagulation.14 A cluster-randomized trial assessed the impact of patient education on knowledge about treatment; it compared patients who received education consisting of a video, a brochure, and a questionnaire with a control group who only received the brochure. 15 It found that patient education resulted in markedly improved safety-related patient knowledge.15Previous studies have shown similar findings of knowledge gap about oral anticoagulants among HCPs.16,17 In a study by Couris et al., HCPs including physicians, pharmacists, and dieticians were surveyed using questions about drug and dietary interactions with warfarin.16 The authors concluded that additional training and improved knowledge base about drug-dietary interactions among HCPs are crucial to provide adequate patient counselling and possibly optimized clinical outcomes.16 Ferguson et al. utilized a paper-based survey distributed during a cardiovascular meeting to assess nurses’ knowledge about warfarin-drug interactions and advise on warfarin dietary interactions, administration, monitoring, and duration of anticoagulation.17 They found that there was very poor knowledge about warfarin anticoagulation among nurses. 17Several “real-world” studies have examined the safety and efficacy of DOACs in patients with atrial fibrillation.18–22 Single-arm observational studies examining the real-world use of rivaroxaban in patients with atrial fibrillation20,21,24,25 and a 2017 systematic review 26 confirmed the safety and efficacy outcomes observed in the ROCKET AF.7 However dabigatran appears to perform differently outside of the randomized controlled trial setting. A 2016 systematic review of 7 post-marketing observational studies, which included 34,8750 patients with atrial fibrillation taking dabigatran, found that dabigatran at either dose showed no benefit over warfarin in prevention of stroke. 23 This finding differs from data reported by the RELY trial, which demonstrated that compared with warfarin, higher dose dabigatran significantly reduced the risk of stroke and systemic embolism.6 This raises the possibility that inappropriate use of dabigatran in clinical practice is contributing to its loss of clinical efficacy. Observational studies22,27 and a 2017 systematic review 28 examining the real-world use of apixaban in patients with atrial fibrillation confirmed the safety and efficacy outcomes observed in the ARISTOTLE.8Our study has some limitations. First, there is a potential for selection bias as we surveyed HCPs at one hospital on a volunteer basis and had a low response rate. The knowledge base of responders may have been different from that of non-responders. Five of the respondents were experts in thrombosis; HCPs’ knowledge might be more subpar if sampling is performed at a centre with no thrombosis expertise. A national study is needed to get a more accurate picture of Canadian practitioners’ understanding of DOACs. However, our study provides an initial look into an area where quality improvement appears to be badly needed. Second, due to its small sample size, our study could not compare the groups demonstrating appropriate understanding relative to those that did not. A larger study may yield information on the impact of specialty and years in practice. Third, as with any cross-sectional study, our study only offers a snapshot of the current practice. Nonetheless, our study is the first of its kind to describe HCPs’ knowledge of DOAC indications and administration, and paves the way for future studies examining the impact of educational programs on medication literacy. ConclusionsThough HCPs express comfort with prescribing DOACs, our study raises concerns around their self-reported knowledge of DOACs use. DOACs are a widely prescribed class of drugs, which can cause serious side effects if not prescribed and taken correctly. It is essential that HCPs provide patients with accurate information and counselling around DOACs, in order to optimize safe and efficacious use. Future studies should focus on educational strategies to improve HCPs’ knowledge base in this area, and associations between medication literacy and the safety and efficacy of DOACs. FundingSP is a recipient of a CanVECTOR thrombosis fellowship.