Bibliografias temáticas / Non-clinical studies

Literatura científica selecionada sobre o tema "Non-clinical studies"

Autor: Grafiati
Publicado: 25 de maio de 2024

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Artigos de revistas sobre o assunto "Non-clinical studies"

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Sitruk-Ware, R. "Non-clinical studies of progesterone". Climacteric 21, n.º 4 (23 de maio de 2018): 315–20. http://dx.doi.org/10.1080/13697137.2018.1463982.

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Swanson, Steven J., e Jeanine Bussiere. "Immunogenicity assessment in non-clinical studies". Current Opinion in Microbiology 15, n.º 3 (junho de 2012): 337–47. http://dx.doi.org/10.1016/j.mib.2012.05.015.

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Molinier, B., M. Henriquet, N. Fourcine e B. Remandet. "Functional immunotoxicity assays in non-clinical studies". Toxicology Letters 205 (agosto de 2011): S149. http://dx.doi.org/10.1016/j.toxlet.2011.05.528.

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Franco, Raúl, Juan M. Rodriguez, Fernanda Elías, Andrés Hernando-Insúa, Juan Fló, Ricardo López, Carlos Nagle et al. "Non-Clinical Safety Studies of IMT504, a Unique Non-CpG Oligonucleotide". Nucleic Acid Therapeutics 24, n.º 4 (agosto de 2014): 267–82. http://dx.doi.org/10.1089/nat.2013.0479.

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Le Tourneau, C., M. Kamal, O. Tredan, C. Gomez-Roca, M. Campone, A. Goncalves, N. Isambert et al. "Poster session 7. Clinical Studies - non-phase 1". Annals of Oncology 24, suppl 1 (1 de março de 2013): i36. http://dx.doi.org/10.1093/annonc/mdt049.

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Singer, C. R. J., e A. H. Goldstone. "Clinical studies of ABMT in non-Hodgkin's lymphoma". Clinics in Haematology 15, n.º 1 (fevereiro de 1986): 105–50. http://dx.doi.org/10.1016/s0308-2261(86)80008-x.

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AWAZU, Shoji. "ISSUES ABOUT CURRENT “GUIDELINES FOR NON - CLINICAL PHARMACOKINETIC STUDIES”". Drug Metabolism and Pharmacokinetics 11, supplement (1996): 5126–27. http://dx.doi.org/10.2133/dmpk.11.supplement_5126.

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AWAZU, Shoji. "Issues about Current "Guidelines for Non-Clinical Pharmacokinetic Studies"." Drug Metabolism and Pharmacokinetics 12, n.º 3 (1997): 217–18. http://dx.doi.org/10.2133/dmpk.12.217.

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Parnham, Michael J., Janice Schindler-Horvat e Marija Kozlović. "Non-Clinical Safety Studies on Biosimilar Recombinant Human Erythropoietin". Basic & Clinical Pharmacology & Toxicology 100, n.º 2 (22 de janeiro de 2007): 73–83. http://dx.doi.org/10.1111/j.1742-7843.2007.00028.x.

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SCHMITT, GERHARD J. "Principles for the conduct of non-drug clinical studies". International Journal of Cosmetic Science 16, n.º 1 (fevereiro de 1994): 39–43. http://dx.doi.org/10.1111/j.1467-2494.1994.tb00080.x.

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Teses / dissertações sobre o assunto "Non-clinical studies"

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Peterson, Colleen Margaret. "Couple Cohesion: Differences Between Clinical and Non-Clinical Mormon Couples". Diss., CLICK HERE for online access, 1988. http://patriot.lib.byu.edu/u?/MTNZ,10566.

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Reid, Tracey J. S. "Obsessions and compulsions : electrophysiological studies in a non-clinical population". Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282300.

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Axelsson, Birger. "Cardiac effects of non-adrenergic inotropic drugs : clinical and experimental studies". Doctoral thesis, Umeå universitet, Anestesiologi och intensivvård, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68967.

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Background: Myocardial failure and dysfunction is not uncommon during critical illness and following cardiac surgery. For optimal treatment, a better understanding of the effects of inotropic drugs is needed. In this thesis, two non-adrenergic mediated inotropes, milrinone and levosimendan were studied in different models of myocardial dysfunction. The study aims were to assess the following: the effects of milrinone on blood flow in coronary artery bypass grafts during CABG surgery; the effects of milrinone on left ventricular diastolic function during post-ischaemic myocardial dysfunction; whether milrinone or levosimendan are protective or injurious during acute myocardial ischaemia, and if levosimendan potentiates myocardial function when added to milrinone in an experimental model of post-ischaemic (stunned) myocardium. Material and Methods: In Study I, 44 patients undergoing coronary artery bypass surgery(CABG) were included as subjects. Milrinone or saline was administrated in a single dose during cardio-pulmonary bypass (CPB) and coronary graft flow measurements were recorded after 10 and 30 min following CPB. In Study II; 24 patients undergoing CABG had estimations of peak ventricular filling rates made before and after CPB with administration of milrinone or saline as a single dose during CPB, performed by assessment of the rate of change in diastolic cross-sectional left ventricular area. In Study III, energy-metabolic effects of milrinone and levosimendan were measured in an anaesthetized porcine model during 45 minutes of regional myocardial ischemia. Microdialysis sampling of metabolites of local ischemic metabolism allowed assessment of glycolytic activity and the degree of myocardial calcium overload. In Study IV, in a porcine model of postischaemic myocardial stunning, ventricular pressure-volume relationships were analyzed when milrinone or a combination of milrinone and levosimendan were given together. Results: In Study I, there was a clear increase in non-sequential saphenous vein graft blood flow with milrinone at 10 minutes (64.5 ± 37.4 compared to placebo 43.6 ± 25.7 ml/min (mean ± SD).). A decreasing but still measureable flow increase was seen for milrinone at 30 minutes. In Study II, an increase in early left ventricular filling rate (ventricular cross-sectional area rate of change,dA/dt) was seen in the milrinone treated group. Pre-bypass milrinone group dA/dt 22.0 ± 9.5 changed to post-bypass values dA/dt 27.8 ± 11.5 cm2/sec). Placebo group pre-bypass dA/dt was 21.0 ± 8.7 and post-bypass 17.1 ± 7.1 cm2/sec. A milrinone effect was demonstrated in an adjusted regression model (p = 0.001). In Study III, neither milrinone nor levosimendan led to a change in energy-metabolic activity during ischemia as reflected by interstitial glucose, pyruvate, lactate orglycerol. Neither drug exacerbated the relative myocardial calcium overload during ischemia. In Study IV, milrinone improved active relaxation (tau) in post-ischemic stunned myocardium, but did not markedly improve systolic function by preload recruitable stroke work. Levosimendan added to milrinone showed minimal effect on active relaxation but a positive effect on systolic function in combination with milrinone. Conclusions: We conclude that milrinone treatment leads to an increase in blood flow in newly implanted coronary saphenous vein grafts, and improves ventricular relaxation post-cardiopulmonary bypass. Neither milrinone nor levosimendan, in this porcine model, negatively influence myocardial energy metabolism or calcium overload during acute ischaemia. Addition of levosimendan to milrinone treatment during post-ischaemic ventricular dysfunction may provide additive inotropic effects on systolic function but probably not for active relaxation.
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Pereira, Stephen Paul. "The pathogenesis and non-surgical treatment of gallstones : clinical and laboratory studies". Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271458.

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Ösby, Eva. "Clinical studies in aggressive non-Hodgkin's lymphoma with special reference to elderly patients /". Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-563-8/.

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Webb, M’Balu Alena. "Studies into the efficacy of using non-purified islets for clinical islet transplantation". Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/10071.

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Islet purification prior to allo transplantation currently forms the clinical gold standard, despite the fact that purification protocols result in significant islet losses and remove potential islet precursors and tissue that may provide islets with bio-trophic support Conversely, non-purified islet preparations retain endocrine mass and within the sphere of islet auto transplantation have been associated with excellent long-term graft function. This study comprises of an analysis of peri-operative factors and the long-term graft function of patients’ auto transplanted with either purified (n=14) or nonpurified islets (n=23). Complementary in-vitro studies were carried out to assess the effect of non-islet tissue on islet viability, integrity and function (n=8), whilst a histology-based study (n=23) assessed whether transplantation of non-islet cells, particularly islet precursors, had a long-term effect on graft function in the clinical setting. Clinically, non-purified islets did not significantly increase peri-transplant venous pressures and perioperative factors including ITU stay, blood loss and liver function were comparable in both groups. Analysis of the 5 year post-transplant period demonstrated that although insulin release in response to glucose was initially superior following transplant of purified islets, non-purified islets were associated with stable long-term function. In-vitro studies reiterated these findings, revealing that islet viability and function were comparable in both groups, however, retention of intracellular insulin was found to be superior within non-purified preparations with some evidence that ductal tissue provided islets with bio-trophic support. Histology-based analysis of patient pancreata suggested a positive role for islet precursors demonstrating significantly superior blood glucose, HbA1c and C-peptide values associated with the transplantation of ductal cells and non-islet PDX-1 and glucagon positive cells. The results of this study indicate that transplantation of non-purified islets can be performed safely and with comparable long-term graft function as purified islets. Additionally, these studies potentially suggest that ductal tissue may help to preserve islet integrity, whilst certain precursors cells found within the acinar parenchyma and ductal epithelium may improve long-term islet graft function.
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Moorthy, Ganesh. "Clinical Pharmacokinetics of the Novel Combination of BEZ235, PI3K/mTOR Inhibitor, and Everolimus, mTOR Inhibitor: Phase I Clinical Studies and Non-clinical Mechanistic Assessment". University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439296033.

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Rafi, Imran. "Phase I clinical and pharmacological studies with the non-classical thymidylate synthase inhibitor AG337". Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265431.

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Twati, Wageh. "Studies on materials and techniques to enhance clinical outcomes for non-vital immature permanent incisors". Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5339/.

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In this thesis three studies are presented all aimed at enhancing outcomes for the endodontic management of non-vital immature permanent incisors. Study 1. Aim: To study the effect of non-setting calcium hydroxide (NSCH) and mineral trioxide aggregate (MTA) on mechanical properties of dentine. Methodology: Approval was obtained from the Tissue bank of the Leeds Dental Institute for the use of human teeth for this study. Twenty-seven human premolar teeth were sectioned to give a total of 54 dentine slabs. Nine slabs used in each group for each of the two time periods: 3 months and 8 months. A thin layer of NSCH or MTA was applied to the slabs, whilst the control group had no application of a medicament. The total period of the study was eight months. Dentine fracture resistance was measured using nano-indentation and by impact test, after which the slabs were Map Scanned for softening after 3 months and then at 8 months. Results: Impact test showed a significant reduction in the fracture resistance of dentine (p<0.001) after 3 and 8 months of application of MTA and NSCH compared with the control group. MTA application had the worst effect on dentine followed by NSCH and control. Also the map scan showed softer areas in the MTA group than the other groups. Conclusion: There was a significant time dependant reduction in the hardness of dentine with NSCH and MTA application. Study 2 The aim: This study was undertaken to evaluate the most effective intra canal medicament against five bacteria commonly implicated in causation of endodontic infections. Methodology: Five bacteria, namely, Actinomyces odontolyticus (NCTC 9335) Porphyromonas gingivalis (W50), Fusobacterium nucleatum (ACTC 10953), Escherichia coli (NCTC 11954) and Enterococcus faecalis (NCTC 755) were selected for this study. The test materials used to evaluate their effect against the chosen bacteria were calcium hydroxide (CH), mineral trioxide aggregate (MTA) and the recently advocated antibiotics (Minocycline, Metronidazole and Ciprofloxicillin), individually and as a Triple mixture. E. coli and E. faecalis were grown in Brain Heart Infusion (BHI) broth under an atmosphere of 10% CO2 + air and incubated at 37ºC. P gingivalis, F. nucleatum and A. odontolytics were grown in BHI broth supplementd with haemin and menadione at a final concentration of 5 µg/ml and 1 µg/µl respectively, all three bacteria were incubated at 37ºC under anaerobic conditions (80% N2, 10% H2 and 10% CO2) in a Mark III anaerobic Work station (Don Whitley Scientific, Shipley, UK). The antimicrobial activity of test materials were determined in agar diffusion assays. Broth cultures of all five bacteria were adjusted in sterile BHI or BHI supplemented with haemin and menadione to an optical density at 540 nm corresponding to 1 x 106 colony forming units (CFU) per ml. Aliquots (100 µl) of bacterial suspensions were inoculated onto the surfaces of Columbia blood agar plates (pre-reduced for anaerobic bacteria). Wells of 3 mm diameter were cut in each plate using a sterile cork borer and test materials applied using a syringe. Zones of inhibition of bacterial growth were measured using a caliper gauge and the mean of three measurements of each zone was calculated, each experiment was carried out on three different occasions. Results: CH, MTA and Metronidazole were not effective against E. faecalis; whereas Ciprofloxacin and Minocycline showed large inhibition zones with all five types of bacteria used in the present study. When all three antibiotics were used as a mixture, they were found to be effective against all five types of bacteria. Conclusions: In the present study the application of triple antibiotic (TriBioDent) was effective against the five common types of bacteria that cause endodontic lesions. Study 3 Aim: To evaluate the toxicity of antibiotics used for regenerative antibiotic technique, both individually and in combination on pulp cell survival. Methodology: Human dental pulp cells obtained from three different donors from the tissue bank were grown until sub-confluence. These were then incubated for 24 hours with culture media supplemented with different antibiotics (50 mg/ml each) in five groups including: 1- Metronidazole, 2- Ciprofloxacin and 3- Minocycline, 4- Metronidazole + Ciprofloxacin and 5- Metronidazole + Ciprofloxacin + Minocycline. Cells grown in culture medium without any antibiotics were used as a control. The experiments were repeated three times and the cell viability was measured using three methods: Lactate Dehydrogenase (LDH) assay, Trypan blue cell counting and flow cytometery. Results: The three methods used to measure the effect of individual or mixed antibiotics on cell viability showed consistent results. Ciprofloxicillin showed a high cytotoxic when compared to the control group that was significantly different (p<0.00). However a combination of two antibiotics, i.e, Metronidazole and Ciprofloxicillin showed a slightly higher cell survival as compared with a combination of all three antibiotics as currently used for the regenerative endodontic technique. Conclusion: In the present study the application of antibiotics used in the regenerative endodontic technique (double or triple antibiotics) was considered to have no significant effect on the survival of pulp cells. There was no difference between using two or three antibiotics in combination.
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Booster, Maurits Harm. "The Non-Heart Beating donor, a new source of kidneys for transplantation clinical and experimental studies /". Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=6644.

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Livros sobre o assunto "Non-clinical studies"

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International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. e Canada Therapeutic Products Directorate, eds. Timing of non-clinical safety studies for the conduct of human clinical trials for pharmaceuticals. Ottawa, Ont: Therapeutic Products Directorate, Health Canada, 1997.

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Bartu, Anne. Evaluation of a preventative intervention strategy in a non-clinical setting using computerised screening. [Perth, W.A.]: Western Australian Alcohol & Drug Authority, 1991.

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Giffney, Noreen. Developing Clinical Insight Using Non-Clinical Case Studies in Psychoanalysis and Psychotherapy. Taylor & Francis Group, 2021.

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Giffney, Noreen. Developing Clinical Insight Using Non-Clinical Case Studies in Psychoanalysis and Psychotherapy. Taylor & Francis Group, 2021.

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Food and Drug Administration Staff. Compact Regs - Good Laboratory Practice for Non-Clinical Laboratory Studies. Taylor & Francis Group, 2004.

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Beckett, Ronald G., Gerald J. Conlogue e Andrew J. Nelson. Case Studies for Advances in Paleoimaging and Other Non-Clinical Applications. CRC Press, 2020. http://dx.doi.org/10.4324/9780429318597.

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Nelson, Andrew, Ronald G. Beckett e Gerald J. Conlogue. Case Studies for Advances in Paleoimaging and Other Non-Clinical Applications. Taylor & Francis Group, 2020.

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Nelson, Andrew, Ronald G. Beckett e Gerald J. Conlogue. Case Studies for Advances in Paleoimaging and Other Non-Clinical Applications. Taylor & Francis Group, 2020.

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Beckett, Ronald G., Andrew J. Nelson e Gerald J. Conlogue. Case Studies for Advances in Paleoimaging and Other Non-Clinical Applications. Taylor & Francis Group, 2020.

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Nelson, Andrew, Ronald G. Beckett e Gerald J. Conlogue. Case Studies for Advances in Paleoimaging and Other Non-Clinical Applications. Taylor & Francis Group, 2020.

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Capítulos de livros sobre o assunto "Non-clinical studies"

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Ferguson, Ryan E., e Mary T. Brophy. "Pilot Studies". In Clinical Trials Design in Operative and Non Operative Invasive Procedures, 235–44. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53877-8_27.

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Foster, John R., Vasanthi Mowat e Chirukandath Gopinath. "Differentiating Adverse and Non-Adverse Findings in Non-Clinical Studies". In Current Topics in Nonclinical Drug Development, 94–148. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003035800-3.

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Jackson, Michael R., e Jack H. Dean. "The minimum non-clinical package for initiating Phase I clinical trials". In The Timing of Toxicological Studies to Support Clinical Trials, 99–108. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1424-0_10.

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Macleod, Malcolm R., Ezgi Tanriver-Ayder, Kaitlyn Hair e Emily Sena. "Design of Meta-Analysis Studies". In Good Research Practice in Non-Clinical Pharmacology and Biomedicine, 299–317. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/164_2019_289.

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Lopez, Nicole E., e Lawrence T. Kim. "Quality Control in Procedural Studies". In Clinical Trials Design in Operative and Non Operative Invasive Procedures, 221–34. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53877-8_26.

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Levy, M. "Non-Steroidal Anti-Inflammatory Drugs: Epidemiological Studies of Adverse Reactions". In Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Pharmacoepidemiology, 41–50. Basel: Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-5722-2_4.

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Moser, Paul. "Out of Control? Managing Baseline Variability in Experimental Studies with Control Groups". In Good Research Practice in Non-Clinical Pharmacology and Biomedicine, 101–17. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/164_2019_280.

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Sukoff Rizzo, Stacey J., Stephanie McTighe e David L. McKinzie. "Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies". In Good Research Practice in Non-Clinical Pharmacology and Biomedicine, 147–62. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/164_2019_282.

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Heim, Manfred E., Henning Flechtner e Bernhard K. Keppler. "Clinical Studies with Budotitane — A New Non-Platinum Metal Complex for Cancer Therapy". In Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy, 217–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74760-1_10.

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Szilagyi, Erzsebet, Nadim Mahmud e Amelia Bartholomew. "The Importance of Non-Human Primate Models for Pre-clinical Studies in Hematopoiesis". In Allogeneic Stem Cell Transplantation, 767–87. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-478-0_43.

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Trabalhos de conferências sobre o assunto "Non-clinical studies"

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Cunha, Matheus Almeida Ribeiro da, João Gustavo dos Anjos Morais Oliveira, Gabriela Sarno Brandão, Ana Flávia Paiva Bandeira Assis, Leonardo Mattos Santos, Isaac Rêgo Purificação, Isabella Trindade Lopes Alves, Mariana Portella Lopes Cruz e Raimundo Nonato Ribeiro Fernandes. "Clinical effects of nonpharmacological treatment of ADHD". In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.488.

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Background: Though pharmacotherapy of Attention Deficit Hyperactivity Disorder (ADHD) is widespread, some patients suffer with side effects or do not improve with it. Objectives: Evaluate clinical outcomes of non-pharmacological therapy on ADHD. Design and Setting: This is a literature review, produced in Bahiana School of Medicine and Public Health. Methods: Articles published between 2011 and 2021 were taken from PubMed, using the following search: (“Non-pharmacological treatment” OR “Non- pharmacological therapy” OR “Non-pharmacological intervention” OR “Non-drug treatment” OR “Non-drug therapy” OR “Adjuvant treatment” OR “Adjuvant therapy”) AND (“ADHD” OR “Attention Deficit-Hyperactivity Disorder”). Studies that did not match this review’s objectives were excluded. Results: 20 of the 57 articles found, were selected. Reviews that approach treatment in general indicate non-pharmacological therapy specially when there are obstacles to use of drugs, but highlight the lack of studies with methodological quality in this field. Clinical studies indicate reduction of symptoms through neurofeedback, transcranial magnetic stimulation, and aerobic exercises. One of the interventions with the most articles was nutritional supplementation, though most of them did not find significant improvement. Conclusions: Non-pharmacological treatment of ADHD is a relevant alternative, especially when there is no response to medication, but studies with better methodological quality are necessary.
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Dominguez, Manuel Carro, Clodagh O'Keeffe, Eugene O'Rourke, Niamh Feerick e Richard B. Reilly. "Cortical Theta Activity and Postural Control in Non-Visual and High Cognitive Load Tasks: Impact for Clinical Studies". In 2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2019. http://dx.doi.org/10.1109/embc.2019.8857663.

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Zheng, Yanxin, Runbin Yan, Yuxin Tang, Borui Zhan, Yue Huang, Dongyao Ni, Xiaoqing Chen e Grace Zhou. "Abstract 2597: Non-clinical studies of systemic delivery of oncolytic virus arms with IL-12 and anti-PD-1 antibody". In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2597.

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Fernandes, Lucca Ferdinando Queiroz, Raiana Carol de Medeiros Dantas, Maria Clara Medeiros Araújo e Lucas de Oliveira Araújo Andrade. "Non-motor clinical manifestations of Parkinson’s disease and its relevance in early diagnosis". In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.100.

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Introduction: Parkinson’s disease is a progressive neurodegenerative disease that affects millions of people worldwide. Although Parkinson’s disease has traditionally been described as a disorder of the motor system, it is now recognized as a complex disease with several clinical features that include neuropsychiatric and non-motor manifestations. Studies show that 97% of patients with Parkinson’s disease report non-motor symptoms, in addition to motor symptoms, and some non-motor characteristics may appear before classic motor signs. Objectives: To list the main non-motor clinical manifestations of Parkinson’s disease and analyze its importance in establishing an accurate and early clinical diagnosis. Methods: This is an integrative review, carried out based on the search of scientific publications indexed in the datebase MEDLINE via PubMed, Lilacs and SciELO. At the end of the searches, 66 publications met the eligibility criteria and were selected to compose the study. Results: Within the non-motor clinical manifestations, there may be present: cognitive dysfunction and dementia, psychosis and hallucinations, mood disorders, sleep disorders, fatigue, autonomic dysfunction, olfactory dysfunction, gastrointestinal dysfunction, pain, sensory disorders and dermatological manifestations. Of these, olfactory dysfunction, constipation, depression and sleep disorders stand out because they often precede the motor symptoms of Parkinson’s disease. Conclusion: In this perspective, it is up to the general practitioner and the neurologist or geriatrician to carry out, whenever possible, screening tests to identify early changes that may precede Parkinson’s disease, guaranteeing patients an early multiprofessional treatment and consequently a better prognosis in the course of the disease.
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de Oliveira Martins Monteiro, Ana Luiza, Laura de Alvarenga Oliveira, Lívia da Silva Terra, Mariana Cristina da Silva Pinheiro, Thalita de Souza Ramos e Luciano Matos Chicayban. "Effects of shock wave therapy on pain in patients with lateral epicondylitis". In 7th International Congress on Scientific Knowledge. Biológicas & Saúde, 2021. http://dx.doi.org/10.25242/8868113820212389.

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Repetitive work or sports activities can cause lateral epicondylitis, causing pain, edema and consequent functional reduction. Shockwave therapy is a non-invasive treatment that consists of using shockwavesin musculoskeletal areas in order to reduce pain and promote soft tissue healing. Identify the effects of shockwave therapy in patients with lateral epicondylitis. Through a systematic review of the literature, randomized clinical trials published among 2002 and 2012, according to the highest score on the PEDro score. The search involved the PEDro and PubMed databases. Six randomized clinical trials with a PEDro score between 7 and 9/10 were selected. In all studies, shockwave therapy was compared to placebo. In 2 studies there was pain reduction, but the other 4 studies showed no significant difference. Shockwave therapy is a relatively new and non-invasive therapeutic procedure, however, it does not provide superior results compared to classic physical therapies in the selected studies.
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Vila, Arber, Mohammad Ahmed, Amirtaha Taebi, Pengfei Dong, Linxia Gu e Peshala Thibbotuwawa Gamage. "A Reduced Order Model for Estimation of Fractional Flow Reserve (FFR) in Coronary Artery Disease: Assessing the Impact of Side Branches". In ASME 2023 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/imece2023-112632.

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Abstract Millions of people worldwide are affected by coronary artery disease (CAD), which is a major cause of morbidity and mortality. To plan effective treatment and stratify risk, it is crucial to evaluate the severity of CAD. Fractional flow reserve (FFR) is a vital parameter used in clinical practice to evaluate CAD severity, which measures the ratio of mean distal coronary pressure to mean aortic pressure during hyperemic conditions. Non-invasive methods for estimating FFR have gained popularity, but computational fluid dynamics (CFD), which is often used, is impractical for routine clinical use due to the time and resources required. To address this issue, a reduced order model is proposed that effectively captures hyperemic conditions and considers the impact of side branch flow on FFR. The model approximates artery sections and branches as Windkessel models and simulates the hyperemic condition by varying microvascular resistance. The study’s preliminary results reveal that the proposed model accurately captures hyperemic conditions and side branch flow’s impact on FFR, providing crucial insights for clinical decision-making. This approach presents a promising way to evaluate CAD severity more efficiently and accurately using non-invasive methods, paving the way for non-invasive assessment of CAD severity. Further studies are necessary to validate the model’s accuracy and potential for clinical translation.
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Klaessens, John H. G. M., Martin Nelisse, Rudolf M. Verdaasdonk e Herke Jan Noordmans. "Non-contact tissue perfusion and oxygenation imaging using a LED based multispectral and a thermal imaging system, first results of clinical intervention studies". In SPIE BiOS, editado por Anita Mahadevan-Jansen, Tuan Vo-Dinh e Warren S. Grundfest. SPIE, 2013. http://dx.doi.org/10.1117/12.2003807.

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Rezende, Karla Viana, Ayrton Senna do Brasil Amaral Alves, Juliana Carollyne Amorim, Maria Inês Vaz de Oliveira, Maria Paula Banhara Rodrigues e Vitor Matias Grah. "Helminth-induced immune response: A new perspective for the treatment of Multiple Sclerosis". In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.603.

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Background: Multiple Sclerole (MS) is a progressive neurodegenerative disease that, in its most common form, evolves in outbreaks and compromises the patient’s quality of life and functionality. In a long time, a way of attenuating symptoms and preventing the progression of this pathology has been studied, however, drug therapies, until now, have not shown good accuracy. In this context, the exogenous use of helminths as non-drug therapy for MS has been considered, therefore, this study aims to demonstrate the recent results of studies on such therapies and verify whether there is scientific evidence of a good clinical, immunological and exam response. image of patients with MS. Methods: Bibliographic review in the PUBMED database Results: The four large studies carried out on the topic demonstrated evidence that the immune response induced by helminths decreases the activity of the immunological factors that contribute to the progression of MS, however the small control groups and unfavorable environments impaired the conclusions of the studies . Conclusions: Although the studies have no yet to demonstrate reliable clinical evidence about exogenous helminth therapy, it is undeniable that the good immune response induced by the parasites is a great hope that motivates the continuation of studies in the area.
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Silva, Gustavo Figueiredo da, Caroline Figueiredo da Silva, Washigton Luiz Gomes de Medeiros Junior e Marcus Vinícius Magno Gonçalves. "Anti -Iglon5 Syndrome: What we know so far? A non-systematic review". In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.237.

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Background: The first report of Anti-IgLON5 syndrome was in 2014. AntiIgLON5 antibodies have a prevalence of 12 in 150,000 patients per year. However, considering the unreported patients, the prevalence can be much higher. Objectives: Provide an overview of the current knowledge of Anti- IgLON5 syndrome. Design and setting: Narrative review. Methods: Non- systematic review on Pubmed database. Results: The IgLON proteins are a family of cell adhesion molecules and the presence of antibodies against IgLON5 is crucial for the AntiIgLON5 Syndrome diagnosis. This syndrome has an expanded clinical spectrum that involves prominent sleep disorder, progressive bulbar dysfunction, gait instability with abnormal eye movements reminiscent, and cognitive deterioration sometimes associated with chorea. The main neuropathological finding is the neuronal loss with hyperphosphorylated tau protein accumulation at the hypothalamus, brainstem tegmentum, hippocampus, periaqueductal gray matter, medulla oblongata, and upper cervical cord. The exact pathogenesis is still unclear and involves a neurodegenerative process and autoimmune response. Early diagnosis is important to avoid unnecessary tests and prevent complications. Important resources for diagnosis are the antibody testing of serum and cerebrospinal fluid for IgLON5-IgG. The Anti-IgLON5 syndrome mortality is high and new studies published described a good response to immune therapy, however, depends on some clinical and analytical characteristics. Conclusions: The Anti-Iglon5 syndrome is a pathology still poorly studied and described in the medical literature (only in case series, for example), being a syndrome probably underdiagnosed. Future studies are needed to thoroughly analyze the aspects of pathogenesis and treatment of this important pathological syndrome.
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ten Cate, J. W., M. V. Huisman e H. R. Buller. "DIAGNOSIS OF DEEP VENOUS THROMBOSIS: NON-INVASIVE VS INVASIVE DIAGNOSTIC PROCEDURES". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642967.

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The clinical diagnosis of deep vein thrombosis (DVT) in symptomatic patients is unreliable. The need for objective diagnostic tests is widely acknowledged. Contrast venography in experienced hands is considered to be the reference method. This method is invasive, uncomfortable to the patient, not easily repeatable and expensive.For this reason several non-invasive tests have been developed and evaluated recently. Of the non-invasive tests impedance plethysmography (IPG) has been thoroughly evaluated in properly designed prospective clinical trials. Serial IPG in symptomatic outpatients is safe and effective. It was shown in longterm follow-up that anticoagulant treatment could be safely withheld in over 500 patients with repeatedly normal IPG (0.3-0.6% recurrence DVT). The specificity for proximal DVT was 92%. The feasability of IPG in symptomatic outpatients was over 95%. The safety of withholding anticoagulant treatment in symptomatic inpatients with a serial normal IPG is an unresolved issue. Preliminary results show that a similar sensitivity might be obtained in inpatients, however, the feasability was lower (87%).Doppler ultrasound has been studied extensively, however, there is a great variation in reported sensitivity for proximal DVT due to the lack of objective diagnostic criteria and the safety of withholding anticoagulant treatment in patients with serial normal Doppler tests results is not es tablished.strain gauge plethysmography has not been evaluated properly and therefore awaits further studies. 125I-fibrinogen legscanning has been shown to be sensitive for calf vein thrombosis (over 90%). In combination with IPG this method is a safe and effective alternative to venography.Radionuclide phlebography has never been evaluated in prospective clinical trials in a broad spectrum of symptomatic patients, and can therefore not be recommended for routine use.It is concluded that presently the management of patients with clinically suspected DVT should be performed with the use of serial IPG, IPG in combination with 125I—fibrinogen legscanning or contrast venog raphy.
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Relatórios de organizações sobre o assunto "Non-clinical studies"

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Peng, Yinglong, Jinwei Chen, Ziyan Wang, Yihui Cao e Jie Zhao. A Systematic Review and meta-analysis of the efficacy of immunotherapy in the treatment of non-small cell lung cancer. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, junho de 2022. http://dx.doi.org/10.37766/inplasy2022.6.0094.

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Review question / Objective: This study aimed to compare the effectiveness of different ICIs in the treatment of NSCLC, and to provide a theoretical basis for clinical selection of different regimens. Condition being studied: Immunotherapy is a relatively new treatment method for non-small cell lung cancer (NSCLC), and clinical studies confirmed that immune checkpoint inhibitors (ICIs) showed prominent efficacy in the treatment of NSCLC patients. This study aimed to compare the effectiveness of different ICIs in the treatment of NSCLC, and to provide a theoretical basis for clinical selection of different regimens.
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López-Valverde, Nansi, Antonio López-Valverde e Jose Antonio Blanco-Rueda. Efficacy of metronidazole on peri-implantitis: A systematic review and meta-analysis of randomized studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, janeiro de 2023. http://dx.doi.org/10.37766/inplasy2023.1.0015.

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Review question / Objective: In patients with peri-implantitis, is adjuvant local or systemic treatment with metronidazole effective on signs of inflammation and bone destruction? Eligibility criteria: Inclusion criteria: a) RCTs (single or double-blind) performed in patients with peri-implantitis defined as bleeding and/or suppuration on peri-implant probing (≥ 4 mm).b) Studies comparing the efficacy of local/systemic metronidazole adjuvant therapy vs. single surgical or non-surgical treatmentc) Articles published in English.Exclusion criteria: a) Less than five patients per treatment group.b) Lack of clinical data on bone destruction.c) Case series or clinical casesd) Undefined cases and non-relevant studies.
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DE ANDRADE, RAUL RIBEIRO, OLAVO BARBOSA DE OLIVEIRA NETO, JOÃO GUSTAVO ROCHA PEIXOTO DOS SANTOS, CÉLIO FERNANDO DE SOUSA RODRIGUES e FABIANO TIMBÓ BARBOSA. Effectiveness of Early Tracheostomy compared with Late Tracheostomy Or Prolonged Orotracheal Intubation in Traumatic Brain Injury: Protocol of Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, janeiro de 2022. http://dx.doi.org/10.37766/inplasy2022.1.0051.

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Review question / Objective: What is the effectiveness of Early Tracheostomy compared with Late Tracheostomy Or Prolonged Orotracheal Intubation in Traumatic Brain Injury? Condition being studied: Traumatic Brain Injury (TBI) is every traumatic anatomical ou functional injury that affects brain, skull and/or vessels related to them. TBI is a public health problem that involves over 50 million people per year in Worldwide. Information sources: PUBLISHED DATABASES (Medline by PUBMED, Lilacs, Central-Cochrane, Scopus by Elsevier, Web Of Science e Embase by Elsevier) NON-PUBLISHED (Open Grey by Sigle; Clinical Trial Register at the International Clinical Trials Registry Platform) (Referencies of the selected studies).
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Cajas, María Augusta, Marcela Cabrera, Jaime Astudillo, Yulissa Abad e Daniela Astudillo. Accuracy in marginal and/or internal adaptation of full-coverage fixed prostheses made with digital versus conventional impressions: an overview of systematic reviews and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, outubro de 2021. http://dx.doi.org/10.37766/inplasy2021.10.0024.

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Review question / Objective: Is the accuracy (marginal adaptation and / or internal adaptation) of fixed full coverage prostheses made with digital impressions better than conventional impressions? Eligibility criteria: Inclusion criteria• Systematic reviews and / or meta-analyzes that evaluated the precision (marginal adaptation and / or internal adaptation) of full coverage fixed prostheses on natural teeth in clinical studies and on tooth replicas in in vitro studies.• Systematic reviews and / or meta-analyzes comparing digital impressions with an intraoral scanner versus conventional impressions taken with any impression material.• Systematic reviews and / or meta-analyzes of randomized clinical trials (RCTs), prospective comparative and in vitro and non-randomized clinical trials.Exclusion criteria:• Systematic literature reviews, case reports, pilot studies• Studies evaluating the seating of crowns on implants and partial restorations• Studies with no response from the author to the requested information query.
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Zhao, Qing, e Lili Zhou. Culture, sex, and their combined impact on self-report empathy—Meta-analyses. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, abril de 2022. http://dx.doi.org/10.37766/inplasy2022.4.0172.

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Condition being studied: The current meta-analysis covers empirical investigations of self-report empathy (evaluated using the EQ and the IRI scales) based on different populations. Studies with general populations and physical/mental clinical populations were included. Both cross-cultural and non-cross-cultural studies (studies based on a single cultural background) were considered. Eligibility criteria: We restricted our current meta-analysis to studies that satisfied all of the following criteria: (1) studies evaluated participants’ self-report empathy using the EQ or the IRI; (2) studies reported the EQ and IRI version (i.e., scale item number and language); (3) studies reported the EQ and IRI total or subscale scores (e.g., mean and SD) based on the overall sample or both sex groups separately. (4) studies reported participants’ cultural backgrounds (e.g., country of origin, nationality, ethnicity, and language).
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Silva, Rodrigo Ribeiro e., Mateus de Miranda Gauza, Julia Opolski Nunes da Silva Opolski e Maria Eduarda Schramm Guisso. Once-Weekly Insulin Icodec vs Once-Daily Insulin Glargine U100 for Type 2 Diabetes: A Meta-analysis of Phase 2 Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, maio de 2022. http://dx.doi.org/10.37766/inplasy2022.5.0102.

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Review question / Objective: To compare Once-Weekly Insulin Icodec and Once-Daily Insulin Glargine U100 in patients with Type 2 Diabetes Mellitus using oral hypoglycemic drugs in need of insulin therapy. Condition being studied: Patients with Diabetes Mellitus Type 2 using oral hypoglycemic drugs in need for basal insulin. Eligibility criteria: Inclusion in this meta-analysis was restricted to studies that met all the following criteria: (1) randomized trials; (2) comparing the use once weekly insulin icodec to once daily insulin glargine; (3) enrolling patients with type 1 or type 2 diabetes mellitus; (4) evaluating any of the desired outcomes; (4) articles in written on english language. We excluded studies with (1) no control group; (2) overlapping studies population; clinical trial register entry only; (3) non-human studies and (4) studies reported only as abstracts.
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Dias, Rita, Miguel Rocha, Lucía Manrique, Sílvia Fraga e Paula Meireles. HIV Prevention Combination Among Men who have Sex with Men: a scoping review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, outubro de 2022. http://dx.doi.org/10.37766/inplasy2022.10.0071.

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Review question / Objective: To map the evidence regarding the combination of prevention strategies used by MSM to manage their HIV risk, assessing how this has been studied and how HIV prevention strategies are being combined by MSM. Eligibility criteria: We will include published scientific documents found through the search expression in the Web of Science, PubMed, and Scopus databases, about HIV prevention in HIV negative MSM. Studies about non-human animals and females will be excluded, as well as non-scientific documents and reports, editorials, opinion papers, comments, revisions, or journalistic material. Documents with no original data, such as reviews and systematic reviews, will also be excluded. Randomized controlled trials and control clinical trials will also be excluded since this type of study does not answer the scoping review questioning. Both quantitative and qualitative, as well as mixed-methods studies, will be included. The specificities of these studies will be properly acknowledged.
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Wu, Chiu-Feng, Tzu-Pei Yeh, Tzu-Chen Lin, Po-Hsiang Huang e Pin-Jui Huang. Effects of far infrared therapy in Hemodialysis Arterio-Venous Fistula Maturation: A Meta-analysis and Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, abril de 2023. http://dx.doi.org/10.37766/inplasy2023.4.0020.

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Review question / Objective: Participant Type: Only for any ESRD patient diagnosed with CKD and established AVF and requiring regular HD treatment with AVF. Intervention type: Studies using FIR therapy versus non- FIR therapy. Outcome Measure Types: Fistula maturation, patency, access blood flow, AVF I.D.; fistula occlusion. P: Patients under hemodialysis. Condition being studied: Far infrared is an invisible electromagnetic wave. Far infrared therapy (FIR) uses low-power electromagnetic waves emitted by FIR with wavelengths of 3-100 µm to improve human physiological functions. Previous studies have shown that FIR can effectively suppress inflammation, and in recent years it has also been widely used in the clinical treatment of various diseases, such as cardiovascular diseases. The use of FIR allows the improvement of AVF blood flow and patency not only through local vasodilation induced by thermal effects, but more importantly, through non-thermal effects that improve endothelial function.
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Gupta, Tejpal, Riddhijyoti Talukdar, Sadhana Kannan, Archya Dasgupta, Abhishek Chatterjee e Vijay Patil. Meta-Analysis of Standard Temozolomide versus Extended Adjuvant Temozolomide following concurrent Radiochemotherapy in newly-diagnosed Glioblastoma (MASTER-G). INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, dezembro de 2021. http://dx.doi.org/10.37766/inplasy2021.12.0114.

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Review question / Objective: To assess the safety and efficacy of extended adjuvant temozolomide compared to standard adjuvant temozolomide after concurrent radiochemotherapy in patients with newly-diagnosed glioblastoma. Condition being studied: Newly-diagnosed glioblastoma. Eligibility criteria: Prospective clinical trials randomly assigning patients to extended (>6-cycles) adjuvant TMZ (experimental arm) or standard (6-cycles) adjuvant TMZ will be included. Randomization in an individual study may have been done upfront before concurrent phase (RT/TMZ), after completion of concurrent RT/TMZ and before starting adjuvant phase, or after completion of standard adjuvant TMZ (6-cycles). Emulated RCTs, quasi-randomized trials, propensity matched analyses, non-randomized comparative studies, or observational studies will not be considered in this review.
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Liao, Jianhua, Jingting Liu, Baoqing Liu, Chunyan Meng e Peiwen Yuan. Effect of OIP5-AS1 on clinicopathological characteristics and prognosis of cancer patients: a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, outubro de 2022. http://dx.doi.org/10.37766/inplasy2022.10.0118.

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Review question / Objective: According to recent studies, long non-coding RNA (lncRNAs) i.e., OPA-interacting protein 5 antisense RNA 1 (OIP5-AS1) has an important role in various carcinomas. However, its role in the cancer is contradictory. Therefore, we aimed to evaluate the link between OIP5-AS1 and cancer patients' clinicopathological characteristics and prognosis to better understand OIP5-AS1's role in cancer. Condition being studied: Reported studies have revealed that long non-coding RNA (lncRNAs) are considerably involved in crucial physiological events in several carcinomas, it can inhibit or promote the occurrence and development of tumors by changing the sequence and spatial structure, modulating epigenetic, regulating the expression level and interacting with binding proteins. However, the mechanism of cancer regulation via lncRNAs was incompletely understood. Hence, clarifying the application value of lncRNAs in preclinical and clinical disease diagnosis and treatment was therefore the prime objective in the field of cancer research at the time.
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