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Mlynczak, Jaroslaw, Krzysztof Kopczynski, Maksymilian Włodarski e Miron Kaliszewski. "Laser dazzler emitting three-colour radiation". Photonics Letters of Poland 14, n.º 1 (31 de março de 2022): 4. http://dx.doi.org/10.4302/plp.v14i1.1129.
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The article presents a laser dazzle generating three overlapping laser beams of different colours and an analysis of the possibility of dazzling people with this radiation. The analysis took into account the eye’s photopic sensitivity and the additivity of the three radiation beams. Such analysis, to the knowledge of the authors, is presented for the first time. The possibility of dazzling for four different dazzle levels and three levels of ambient luminance was presented. It has been shown that in some conditions it is possible to damage the eye without causing the assumed dazzle effect. Full Text: PDF ReferencesJoint Non-Lethal Weapons Program, Non-Lethal Optical Distracters Fact Sheet, (2016). DirectLink https://www.faa.gov/about/initiatives/lasers/laws/ DirectLink N. Raoof, et al., "‘Toy’ laser macular burns in children", Eye 28, 231 (2014). CrossRef D. B. Gosling, J. B. O'Hagan, and F. M. Quhill, "Blue Laser Induced Retinal Injury in a Commercial Pilot at 1300 ft", Aerospace Medicine and Human Performance 87, 69 (2016). CrossRef J. Marshall, J. B. O'Hagan, and J. R. Tyrer, "Eye hazards of laser ‘pointers’ in perspective", Br. J. Ophthalmol. 100, 583 (2016). CrossRef N. Raoof, J. O'Hagan, N. Pawlowska, and F. Quhill, "Toy’ laser macular burns in children: 12-month update", Eye 30, 492 (2016). CrossRef S. Androudi and E. Papageorgiou, "Macular Hole from a Laser Pointer", New England Journal of Medicine 378, 2420 (2018) CrossRef J. E. Neffendorf, G. D. Hildebrand and S. M. Downes, "Handheld laser devices and laser-induced retinopathy (LIR) in children: an overview of the literature", Eye 33, 1203 (2019). CrossRef E. Linton, et al., "Retinal burns from laser pointers: a risk in children with behavioural problems", Eye 33, 492 (2019). CrossRef P. Dockrill, Science alert, (2020). DirectLink IEC 60825-1:2014, Safety of laser products - Part 1: Equipment classification and requirements (International Electrotechnical Commission 2014). DirectLink ANSI Z136.1-2014, American National Standard for Safe Use of Lasers (American National Standards Institute 2014). DirectLink C. A. Williamson and L. N. McLin, "Nominal ocular dazzle distance (NODD)", Appl. Opt. 54, 1564 (2015). CrossRef C. A. Williamson and L. N. McLin, "Determination of a laser eye dazzle safety framework", Journal of Laser Applications 30, 032010 (2018). CrossRef J. Mlynczak, K. Kopczynski, M. Kaliszewski, M. Wlodarski, "Estimation of nominal ocular hazard distance and nominal ocular dazzle distance for multibeam laser radiation", Applied Optics, 60(22), 6414-6421 (2021). CrossRef CVRL Database, CVRL functions, Luminous efficiency functions, 2-deg functions. DirectLink Peter Lennie, Joel Pokorny, and Vivianne C. Smith, "Luminance", Journal of the Optical Society of America A, 10 (6), 1283-1293, (1993) CrossRef H. Cai and T. Chung, "Evaluating discomfort glare from non-uniform electric light sources", Lighting Research & Technology, 45 (3), 267-294 (2012). CrossRef
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Meiksin, Rebecca, Jo Crichton, Matthew Dodd, Gemma S. Morgan, Pippa Williams, Micky Willmott, Elizabeth Allen et al. "A school intervention for 13- to 15-year-olds to prevent dating and relationship violence: the Project Respect pilot cluster RCT". Public Health Research 8, n.º 5 (março de 2020): 1–338. http://dx.doi.org/10.3310/phr08050.
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Background ‘Dating and relationship violence’ is intimate partner violence during adolescence. Among dating adolescents in England, 66–75% of girls and 32–50% of boys report victimisation. Multicomponent school-based interventions might reduce dating and relationship violence. We optimised and piloted Project Respect, a new intervention in secondary schools in England, and study methods, to assess the value of a Phase III randomised controlled trial. Objectives To optimise Project Respect and to then conduct a pilot randomised controlled trial in southern England, addressing whether or not progression to a Phase III trial is justified in terms of prespecified criteria. To assess which of two dating and relationship violence scales is optimal, to assess response rates and to consider any necessary refinements. Design Optimisation activities aimed at intervention development and a pilot randomised controlled trial. Setting Optimisation in four secondary schools across southern England, varying by region and local deprivation. A pilot cluster randomised controlled trial in six other such schools (four intervention schools and two control schools), varying by region, attainment and local deprivation. Participants School students in years 8–10 at baseline and staff. Interventions Schools were randomised to the intervention or control arm in a 2 : 1 ratio; intervention comprised staff training, mapping ‘hotspots’ in school for dating and relationship violence, modifying staff patrols, school policy review, informing parents and carers, an application supporting student help-seeking, and a classroom curriculum for students in years 9 and 10 (including student-led campaigns). Main outcome measures Prespecified criteria for progression to Phase III of the trial, concerning acceptability, feasibility, fidelity and response rates. Primary health outcomes were assessed using the Safe Dates and short Conflicts in Adolescent Dating Relationships Inventory measures collected and analysed by individuals who were masked to allocation. Feasibility of economic analysis was assessed. Data sources Baseline and follow-up student and staff surveys, interviews, observations and logbooks. Results The intervention was optimised and approved by the Study Steering Committee. The student response rates in intervention and control groups were 1057 (84.8%) and 369 (76.6%) at baseline, and 1177 (76.8%) and 352 (83.4%) at follow-up, respectively. Safe Dates and the short Conflicts in Adolescent Dating Relationships Inventory had high levels of completion and reliability. At follow-up, prevalence of past-year dating and relationship violence victimisation was around 35% (Safe Dates scale and short Conflicts in Adolescent Dating Relationships Inventory). Staff response rates were very low. Training occurred in all four schools, with suboptimal fidelity. The curriculum was delivered with optimal fidelity in three schools. Other components were delivered inconsistently. Dating and relationship violence was addressed in control schools via violence prevention and responses, but not systematically. Intervention acceptability among students and staff was mixed. An economic evaluation would be feasible. Limitations One school did not undertake baseline surveys. Staff survey response rates were low and completion of the logbook was patchy. Conclusions Our findings suggest that progression to a Phase III trial of this intervention is not indicated because of limited fidelity and acceptability. Future work High prevalence of dating and relationship violence highlights the ongoing need for effective intervention. Potential intervention refinements would include more external support for schools and enhanced curriculum materials. Any future randomised controlled trials could consider having a longer lead-in from randomisation to intervention commencement, using the short Conflicts in Adolescent Dating Relationships Inventory as the primary outcome and not relying on staff surveys. Trial registration Current Controlled Trials ISRCTN65324176. Funding This project was funded by the National Institute for Health Research (NIHR) Public Health Research programme and will be published in full in Public Health Research; Vol. 8, No. 5. See the NIHR Journals Library website for further project information.
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Good, Michael I. "Meeting of the Psychoanalytic Institute Of New England, East". Psychoanalytic Quarterly 55, n.º 3 (julho de 1986): 556–62. http://dx.doi.org/10.1080/21674086.1986.11927156.
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Klavens, George S. "Meeting of the Psychoanalytic Institute of New England, East". Psychoanalytic Quarterly 56, n.º 3 (julho de 1987): 605–8. http://dx.doi.org/10.1080/21674086.1987.11927189.
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Barron, James W. "Meeting of the Psychoanalytic Institute of New England, East". Psychoanalytic Quarterly 57, n.º 1 (janeiro de 1988): 141–46. http://dx.doi.org/10.1080/21674086.1988.11927208.
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Diamond, David B. "Meeting of the Psychoanalytic Institute of New England, East". Psychoanalytic Quarterly 58, n.º 2 (abril de 1989): 333–40. http://dx.doi.org/10.1080/21674086.1989.11927242.
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Stambler, Morris J. L. "Meetings of the Psychoanalytic Institute of New England, East". Psychoanalytic Quarterly 59, n.º 2 (abril de 1990): 341–45. http://dx.doi.org/10.1080/21674086.1990.11927275.
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Goldsmith, Gary. "Meetings of the Psychoanalytic Institute of New England, East". Psychoanalytic Quarterly 60, n.º 2 (abril de 1991): 356–60. http://dx.doi.org/10.1080/21674086.1991.11927314.
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Figman, Robert. "Meeting of the Psychoanalytic Institute of New England, East". Psychoanalytic Quarterly 60, n.º 4 (outubro de 1991): 716–18. http://dx.doi.org/10.1080/21674086.1991.11927329.
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Stambler, Morris, Robert L. Pyles e Graham Spruiell. "Meetings of the Psychoanalytic Institute of New England, East". Psychoanalytic Quarterly 61, n.º 2 (abril de 1992): 326–30. http://dx.doi.org/10.1080/21674086.1992.11927346.
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García Dorta, A., H. D. Marta, L. Medina Vega, J. J. Villacampa Jiménez, J. J. Bethencourt Baute, A. Alvárez Díaz, C. Luna-Gomez, F. Álvarez Reyes, S. Machín García e S. Bustabad. "FRI0577 VITAMIN D LEVEL IN HEALTHY CANARIAN ADULT POPULATION". Annals of the Rheumatic Diseases 79, Suppl 1 (junho de 2020): 892.2–892. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4928.
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Background:Vitamin D (VitD) was first used to treat rickets in children in depressed urban areas of England, due to malnutrition and lower sun exposure. During the last decade its use has become widespread in western societies because it has been associated with lower risk of suffering from multiple diseases and there is also a lack of consensus in establishing adequate levels for the general population. Regarding the beneficial effects of VitD, well-designed current observational studies are calling them into question and many authors believe that levels of 30 ng/mL, adopted as optimal, are overestimated1-2. All this has led many individuals who come to our consultations to use supplements without scientific evidence of their benefits.Objectives:The main objective was to determine the distribution of VitD levels in the healthy canarian population, an area with high solar radiation and stratified according to demographic factors (age, sex and place of residence). As a secondary objective, the study was established to determine prevalence of hyperparathyroidism hypercalcemic in the canarian population.Methods:Cross-sectional population study to determine VitD levels in healthy subjects. The EPIRCAN study screen was used, a population study carried out between 2004 and 2005 to determine the prevalence of rheumatic diseases in the Canary Islands. In 949 serums, the levels of VitD, phosphorus and calcium were determined, as well as Parathyroid hormone (PTH), only in which calcium levels were >10,4 mg/dl. Data were analysed according to demographic characteristics, comorbidities and medication. For the statistical analysis the SPSS was used.Results:The sociodemographic characteristics (age, sex and rural/urban population) of the 949 samples were representative of the Canarian population in the period studied according to data of the ISTAC (Canary Institute of Statistics) with a level of accuracy of 0.7 ng/ml for the vitD and a confidence level of 95%. Healthy (n=876, 92.3%) and sick subjects (n= 73, 7.7%) (renal failure, dialysis, Crohn’s, ulcerative colitis, osteoporosis, calcium supplements, vitD, bisphosphonates or calcitonin). The median and Interquartile range of vitD levels in the entire population studied was 26.3 (20.9-32.9) ng/ml. The VitD levels distribution of healthy population was: 66% were below 30 ng/ml,23% were below 20 mg/ml and 4% were below 12,5 ng/ml. According to the age groups, sex and location: women versus men have 2.8 ng/ml less VitD (CI95%: 1.487;4.177). As the age increases the VitD values decrease; those aged 20-45 with respect to ≥65 years have 5.5 ng/ml more (CI95%: 3.574;7.592), those 45-65 years old have 2.397 ng/ml more (CI95% 0.255;4.539) with respect to ≥65 years, being statistically significant. There were no significant differences between the rural and urban population. The prevalence of hyperparathyroidism hypercalcemic was 0.2%.Conclusion:In the healthy population, baseline levels of VitD are higher in men than in women and tend to decrease with age. Due to the distribution of VitD levels in a healthy population, in an area of high sun exposure, seems to be more reasonable to establish the optimal VitD levels in the general population at 20 ng/ml instead of the established 30 mg/ml.References:[1] F. Wu et al. Cut-points for associations between vitamin D status and multiple musculoskeletal outcomes in middle-aged women. (2017). Osteoporosis International; Volume 28, Issue 2, pp 505–515.[2] E. Manson, J. (2016). Vitamin D Deficiency — Is There Really a Pandemic? The New England Journal of Medicine, pp.75;19.Disclosure of Interests:None declared
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Good, Michael, e Ralph Beaumont. "Meetings of the Psychoanalytic Institute and Society of New England, East". Psychoanalytic Quarterly 61, n.º 4 (outubro de 1992): 688–91. http://dx.doi.org/10.1080/21674086.1992.11927362.
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STEKOLSHCHIKOV, ANDREY V., e TATIANA A. NOVGORODOVA. "A new species of Aspidophorodon Verma (Hemiptera, Aphididae) from the Altai Republic". Zootaxa 2566, n.º 1 (13 de agosto de 2010): 39. http://dx.doi.org/10.11646/zootaxa.2566.1.3.
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Aspidophorodon (Eoessigia) vera, sp. nov. is described from specimens collected in the Altai Republic on Pentaphylloides fruticosa. Apterous viviparous females are described and illustrated, and biometric data provided. This aphid species is closely related to A. (E.) indica (David, Rajasingh et Narayanan, 1972). Type specimens are deposited at the Institute of Systematics and Ecology of Animals, Siberian Branch of the Russian Academy of Sciences (Novosibirsk, Russia), the Zoological Institute, the Russian Academy of Sciences (St. Petersburg, Russia), and the Natural History Museum (London, England).
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Drayson, Mark T., Stella Bowcock, Tim Planche, Gulnaz Iqbal, Guy Pratt, Kwee Yong, Jill Wood et al. "Prophylactic levofloxacin to prevent infections in newly diagnosed symptomatic myeloma: the TEAMM RCT". Health Technology Assessment 23, n.º 62 (novembro de 2019): 1–94. http://dx.doi.org/10.3310/hta23620.
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Background Myeloma causes profound immunodeficiency and recurrent serious infections. There are approximately 5500 new UK cases of myeloma per annum, and one-quarter of patients will have a serious infection within 3 months of diagnosis. Newly diagnosed patients may benefit from antibiotic prophylaxis to prevent infection. However, the use of prophylaxis has not been established in myeloma and may be associated with health-care-associated infections (HCAIs), such as Clostridium difficile. There is a need to assess the benefits and cost-effectiveness of the use of antibacterial prophylaxis against any risks in a double-blind, placebo-controlled, randomised clinical trial. Objectives To assess the risks, benefits and cost-effectiveness of prophylactic levofloxacin in newly diagnosed symptomatic myeloma patients. Design Multicentre, randomised, double-blind, placebo-controlled trial. A central telephone randomisation service used a minimisation computer algorithm to allocate treatments in a 1 : 1 ratio. Setting A total of 93 NHS hospitals throughout England, Northern Ireland and Wales. Participants A total of 977 patients with newly diagnosed symptomatic myeloma. Intervention Patients were randomised to receive levofloxacin or placebo tablets for 12 weeks at the start of antimyeloma treatment. Treatment allocation was blinded and balanced by centre, estimated glomerular filtration rate and intention to give high-dose chemotherapy with autologous stem cell transplantation. Follow-up was at 4-week intervals up to 16 weeks, with a further follow-up at 1 year. Main outcome measures The primary outcome was to assess the number of febrile episodes (or deaths) in the first 12 weeks from randomisation. Secondary outcomes included number of deaths and infection-related deaths, days in hospital, carriage and invasive infections, response to antimyeloma treatment and its relation to infection, quality of life and overall survival within the first 12 weeks and beyond. Results In total, 977 patients were randomised (levofloxacin, n = 489; placebo, n = 488). A total of 134 (27%) events (febrile episodes, n = 119; deaths, n = 15) occurred in the placebo arm and 95 (19%) events (febrile episodes, n = 91; deaths, n = 4) occurred in the levofloxacin arm; the hazard ratio for time to first event (febrile episode or death) within the first 12 weeks was 0.66 (95% confidence interval 0.51 to 0.86; p = 0.002). Levofloxacin also reduced other infections (144 infections from 116 patients) compared with placebo (179 infections from 133 patients; p-trend of 0.06). There was no difference in new acquisitions of C. difficile, methicillin-resistant Staphylococcus aureus and extended-spectrum beta-lactamase Gram-negative organisms when assessed up to 16 weeks. Levofloxacin produced slightly higher quality-adjusted life-year gains over 16 weeks, but had associated higher costs for health resource use. With a median follow-up of 52 weeks, there was no significant difference in overall survival (p = 0.94). Limitations Short duration of prophylactic antibiotics and cost-effectiveness. Conclusions During the 12 weeks from new diagnosis, the addition of prophylactic levofloxacin to active myeloma treatment significantly reduced febrile episodes and deaths without increasing HCAIs or carriage. Future work should aim to establish the optimal duration of antibiotic prophylaxis and should involve the laboratory investigation of immunity, inflammation and disease activity on stored samples funded by the TEAMM (Tackling Early Morbidity and Mortality in Myeloma) National Institute for Health Research Efficacy and Mechanism Evaluation grant (reference number 14/24/04). Trial registration Current Controlled Trials ISRCTN51731976. Funding details This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 62. See the NIHR Journals Library website for further project information.
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Taylor, Rod. "NATIONAL INSTITUTE FOR CLINICAL EXCELLENCE (NICE)". International Journal of Technology Assessment in Health Care 18, n.º 2 (abril de 2002): 166–70. http://dx.doi.org/10.1017/s026646230200017x.
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The technology appraisal program of the National Institute for Clinical Excellence (NICE) was established on April 1, 1999. Its role is to advise the NHS in England and Wales on the clinical effectiveness, cost-effectiveness, and service impact of new and emerging as well as established healthcare technologies. This paper describes the role of HTA in the NICE technology appraisal process, discusses some of the challenges of the use of HTA in national policy making, and considers some of the potential ways forward.
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Milbourn, Graham, e Roger Holland. "Vegetable Cultivar Evaluation in England and Wales: Developments and Economies". HortScience 22, n.º 6 (dezembro de 1987): 1214–16. http://dx.doi.org/10.21273/hortsci.22.6.1214.
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Abstract The oversupply of agricultural commodities, including vegetables, in the United Kingdom has led the government to urge decreases in expenditures on the official cultivar testing program. At the same time, the submission of new lines by breeders into the test program continues unabated. In summarizing the vegetable cultivar assessment program, as carried out in England and Wales by the National Institute of Agricultural Botany (NIAB), both for the statutory National Listing requirements and for the production of Recommended Lists for vegetable growers, the emphasis therefore will be on the development of new techniques, particularly with a view to cost savings.
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Bartley, Maggie. "Report of the ALCTS New England Collection Management and Development Institute, July 27–29, 1995". Library Acquisitions: Practice & Theory 20, n.º 2 (junho de 1996): 163–76. http://dx.doi.org/10.1016/0364-6408(96)00017-8.
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Renner, Melinda. "NELLCO International Fellowship – What a Thrill!" Legal Information Management 7, n.º 4 (dezembro de 2007): 289–93. http://dx.doi.org/10.1017/s1472669607002162.
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AbstractMelinda Renner, from the University of New Brunswick, writes about her experiences as a New England Law Library Consortium International Fellow who was seconded to the Institute of Advanced Legal Studies in London. She describes the visits she made and her impressions of how academic librarianship in Britain and Canda appear to share many of the same issues and problems.
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Clark, Andrew. "New Ways of Working is dead, long live New Ways of Working! Revised joint guidance on the employment of consultant psychiatrists". Psychiatrist 34, n.º 4 (abril de 2010): 149–50. http://dx.doi.org/10.1192/pb.bp.109.025551.
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SummaryIn 2005 the Royal College of Psychiatrists, the NHS Confederation, the National Institute for Mental Health in England and the Department of Health jointly produced the first edition of the Joint Guidance on the Employment of Consultant Psychiatrists. This was integral to the New Ways of Working initiative and outline different professional roles within mental health services. Four years on the document has been extensively revised. The new 2009 edition emphasises achieving viable and satisfying consultant posts through effective job planning and good team functioning. It also contains guidance on recruitment processes with useful examples of templates, flowcharts and good practices.
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Watton, Cherish, e Tiia Sahrakorpi. "Scrapbooks as Sites of Technology: The Women’s Institute and the Material Culture of 1960s Rural England". Technology and Culture 65, n.º 3 (julho de 2024): 843–67. http://dx.doi.org/10.1353/tech.2024.a933097.
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abstract: Using scrapbooks created by members of the Women’s Institute in England in 1965, this article offers a rare insight into women’s lived experience and interaction with new technologies and services, in domestic and communal spaces, which show how rural women diligently recorded the new behaviors, emotions, and challenges surrounding rural life. Scrapbookers show multiple and sometimes contradictory attitudes, representing themselves as modern housewives proficient with new consumer durables, while also critiquing the inequalities heralded by new goods and services. Rural women were not simply bystanders to technological change but represented themselves as both consumers and producers of new forms of knowledge, through their use of material culture. Scrapbookers used their creations to archive the emotional labor they performed in their homes and communities, illuminating an important but often overlooked component of consumption.
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Litwin, Dariusz, Jacek Galas, Marek Daszkiewicz, Tadeusz Kryszczyński, Adam Czyżewski e Kamil Radziak. "Dedicated optical systems of the Institute of Applied Optics". Photonics Letters of Poland 11, n.º 2 (1 de julho de 2019): 29. http://dx.doi.org/10.4302/plp.v11i2.898.
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The paper presents a collection of selected optical systems recently developed in the Institute of Applied Optics-INOS. The collection includes the family of techniques where the continuously modified wavelength facilitates high accuracy measurements of optical and geometrical features of the object in question i.e. the variable wavelength interferometry and confocal chromatic sensors. In addition, the paper refers to the construction of a new type of a spectrometer with rotating plasma and an illumination system supporting the road safety. Full Text: PDF ReferencesM. Pluta, Advanced Light Microscopy (Vol. 3, PWN, Elsevier, Warszawa-Amsterdam-London-New York-Tokyo, 1993). DirectLink M. Pluta, "Object-adapted variable-wavelength interferometry. I. Theoretical basis", Journal of Opt. Soc. Am., A4(11), 2107 (1987). CrossRef M. Pluta, "Variable wavelength microinterferometry of textile fibres", J. Microscopy, 149(2), 97 (1988). CrossRef M. Pluta, "On double‐refracting microinterferometers which suffer from a variable interfringe spacing across the image plane", Journal of Microscopy, 145(2), 191 (1987). CrossRef K. A. El-Farahaty, A. M. Sadik, A. M. Hezma, "Study of Optical and Structure Properties of Polyester (PET) and Copolyester (PETG) Fibers by Interferometry", International Journal of Polymeric Materials 56(7),715 (2007). CrossRef J. Galas, D. Litwin, M. Daszkiewicz, "New approach for identifying the zero-order fringe in variable wavelength interferometry", Proc. SPIE 10142, 101421R (2016). CrossRef A. Sadik, W. A. Ramadan, D. Litwin, "Variable incidence angle method combined with Pluta polarizing interference microscope for refractive index and thickness measurement of single-medium fibres", Measurement Science and Technology, IOP Publishing 14(10), 1753 (2003). CrossRef J. Galas, S. Sitarek; D. Litwin; M. Daszkiewicz, "Fringe image analysis for variable wavelength interferometry", Proc. SPIE 10445, 1044504 (2017). CrossRef D. Litwin, A. M. Sadik, "Computer-aided variable wavelength Fourier transform polarizing microscopy of birefringent fibers.", Optica Applicata 28(2), 139 (1998). DirectLink D. Litwin, J. Galas, N. Błocki, "Automated variable wavelength interferometry in reflected light mode", Proc.SPIE 6188, 61880F (2006). CrossRef M. Pluta, "Variable wavelength interferometry of birefringent retarders", Opt. Laser Technology, 19(3), 131 (1987). CrossRef K. Fladischer et al. "An ellipsoidal mirror for focusing neutral atomic and molecular beams", New journal of Physics, 12(3) 033018 (2010). CrossRef K. Fladischer et al. "An optical profilometer for characterizing complex surfaces under high vacuum conditions", Precision engineering Elsevier 32(3), 182 (2008). CrossRef A.E. Weeks et al. "Accurate surface profilometry of ultrathin wafers", Semiconductor Science and Technology", IOP Publishing, 22(9), 997 (2007). CrossRef D. Litwin et al. "Overview of the measuring systems where a continuously altered light source plays a key role: Part I", Proc. SPIE 10808, 10 8080B (2018). CrossRef D. Litwin et al. "Noise reduction in an optical emission spectrometer with rotating diffraction grating", Proc. SPIE 10142 101421Q (2016). CrossRef D. Litwin et al. "Photonics approach to traffic signs", Proc SPIE 10142 1014214, (2016). CrossRef
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Kompanets, Oleg N. "New developments of optical spectral instruments in the Institute of Spectroscopy, RAS". Uspekhi Fizicheskih Nauk 169, n.º 3 (1999): 355. http://dx.doi.org/10.3367/ufnr.0169.199903o.0355.
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Kompanets, Oleg N. "New developments of optical spectral instruments in the Institute of Spectroscopy, RAS". Physics-Uspekhi 42, n.º 3 (31 de março de 1999): 290–92. http://dx.doi.org/10.1070/pu1999v042n03abeh000533.
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Middleton, Sue C. "New Zealand Theosophists in “New Education” networks, 1880s-1938". History of Education Review 46, n.º 1 (5 de junho de 2017): 42–57. http://dx.doi.org/10.1108/her-10-2015-0024.
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Purpose It is well-known that Beatrice Ensor, who founded the New Education Fellowship (NEF) in 1921, was a Theosophist and that from 1915 the Theosophical Fraternity in Education she established laid the foundations for the NEF. However, little research has been performed on the Fraternity itself. The travels of Theosophists, texts, money and ideas between Auckland, India and London from the late nineteenth century offer insights into “New Education” networking in the British Commonwealth more broadly. The paper aims to discuss these issues. Design/methodology/approach This paper draws on archival documents from the Adyar Library and Research Centre, International Theosophical Society (TS) headquarters, Chennai, India; the archive at the headquarters of the New Zealand Section of the TS, Epsom, Auckland; the NEF files at the archive of the London Institute of Education; papers past digital newspaper archive. Findings New Zealand’s first affiliated NEF group was set up by the principal of the Vasanta Gardens Theosophical School, Epsom, in 1933. She was also involved in the New Zealand Section of the Theosophical Fraternity, which held conferences from 1917 to 1927. New Zealand’s Fraternity and Theosophical Education Trust had close links with their counterparts in England and India. The setting up of New Zealand’s first NEF group was enabled by networks created between Theosophists in New Zealand, India and England from the late nineteenth century. Originality/value The contribution of Theosophists to the new education movement has received little attention internationally. Theosophical educational theory and Theosophists’ contributions to New Zealand Education have not previously been studied. Combining transnational historiography with critical geography, this case study of networks between New Zealand, Adyar (India) and London lays groundwork for a wider “spatial history” of Theosophy and new education.
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Hassiotis, Angela, Michaela Poppe, Andre Strydom, Victoria Vickerstaff, Ian Hall, Jason Crabtree, Rumana Omar et al. "Positive behaviour support training for staff for treating challenging behaviour in people with intellectual disabilities: a cluster RCT". Health Technology Assessment 22, n.º 15 (março de 2018): 1–110. http://dx.doi.org/10.3310/hta22150.
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Background Preliminary studies have indicated that training staff in Positive Behaviour Support (PBS) may help to reduce challenging behaviour among people with intellectual disability (ID). Objective To evaluate whether or not such training is clinically effective in reducing challenging behaviour in routine care. The study also included longer-term follow-up (approximately 36 months). Design A multicentre, single-blind, two-arm, parallel-cluster randomised controlled trial. The unit of randomisation was the community ID service using an independent web-based randomisation system and random permuted blocks on a 1 : 1 allocation stratified by a staff-to-patient ratio for each cluster. Setting Community ID services in England. Participants Adults (aged > 18 years) across the range of ID with challenging behaviour [≥ 15 Aberrant Behaviour Checklist – Community total score (ABC-CT)]. Interventions Manual-assisted face-to-face PBS training to therapists and treatment as usual (TAU) compared with TAU only in the control arm. Main outcome measures Carer-reported changes in challenging behaviour as measured by the ABC-CT over 12 months. Secondary outcomes included psychopathology, community participation, family and paid carer burden, family carer psychopathology, costs of care and quality-adjusted life-years (QALYs). Data on main outcome, service use and health-related quality of life were collected for the 36-month follow-up. Results A total of 246 participants were recruited from 23 teams, of whom 109 were in the intervention arm (11 teams) and 137 were in the control arm (12 teams). The difference in ABC-CT between the intervention and control arms [mean difference –2.14, 95% confidence interval (CI) –8.79 to 4.51; p = 0.528] was not statistically significant. No treatment effects were found for any of the secondary outcomes. The mean cost per participant in the intervention arm was £1201. Over 12 months, there was a difference in QALYs of 0.076 in favour of the intervention (95% CI 0.011 to 0.140 QALYs) and a 60% chance that the intervention is cost-effective compared with TAU from a health and social care cost perspective at the threshold of £20,000 per QALY gained. Twenty-nine participants experienced 45 serious adverse events (intervention arm, n = 19; control arm, n = 26). PBS plans were available for 33 participants. An independent assessment of the quality of these plans found that all were less than optimal. Forty-six qualitative interviews were conducted with service users, family carers, paid carers and service managers as part of the process evaluation. Service users reported that they had learned to manage difficult situations and had gained new skills, and carers reported a positive relationship with therapists. At 36 months’ follow-up (n = 184), the mean ABC-CT difference between arms was not significant (–3.70, 95% CI –9.25 to 1.85; p = 0.191). The initial cost-effectiveness of the intervention dissipated over time. Limitations The main limitations were low treatment fidelity and reach of the intervention. Conclusions Findings from the main study and the naturalistic follow-up suggest that staff training in PBS as delivered in this study is insufficient to achieve significant clinical gains beyond TAU in community ID services. Although there is an indication that training in PBS is potentially cost-effective, this is not maintained in the longer term. There is increased scope to develop new approaches to challenging behaviour as well as optimising the delivery of PBS in routine clinical practice. Trial registration This study is registered as NCT01680276. Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 22, No. 15. See the NIHR Journals Library website for further project information.
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Levine, Howard. "Entrevista com Howard Levine". Psicanálise - Revista da Sociedade Brasileira de Psicanálise de Porto Alegre 20, n.º 1 (6 de janeiro de 2018): 211–18. http://dx.doi.org/10.60106/rsbppa.v20i1.665.
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Neste número da revista Psicanálise, tivemos a honra de entrevistar o psicanalista americano Howard Levine. O doutor Levine, que gentilmente nos concedeu esta entrevista, é um pesquisador dedicado ao estudo das representações, estados não representados da mente e a construção de significados. Possui um livro recente sobre o tema organizado com Gail S. Reed e Dominique Scarfone, publicado em português, numa associação entre as editoras Blucher e Karnac. Além disto, Levine, também é docente no Psychoanalytic Institute of New England East, analista supervisor do Massachusetts Institute for Psychoanalysis e psicanalista clínico em Brookline. Também é membro fundador do Boston Change Process Study Group e do Boston Group for Psychoanalytic Studies. [...]
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Otuonye, Ifeoma S., Reiner Banken, Varun M. Kumar e Steven D. Pearson. "A Summary from the Institute for Clinical and Economic Review’s New England Comparative Effectiveness Public Advisory Council". Journal of Managed Care & Specialty Pharmacy 25, n.º 6 (junho de 2019): 630–34. http://dx.doi.org/10.18553/jmcp.2019.25.6.630.
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Patel, Sanjay, e Stephen Byrnes. "INTRA-LIMBAL LENS DESIGN FOR IRREGULAR ASTIGMATISM FOLLOWING RADIAL KERATOTOMY. THE NEW ENGLAND EYE INSTITUTE, BOSTON, MA." Optometry and Vision Science 79, Supplement (dezembro de 2002): 131. http://dx.doi.org/10.1097/00006324-200212001-00249.
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Heise, Colleen Dwyer, e Christopher C. Rimmer. "Definitive Prebasic Molt of Gray Catbirds at two Sites in New England". Condor 102, n.º 4 (1 de novembro de 2000): 894–904. http://dx.doi.org/10.1093/condor/102.4.894.
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Abstract We studied the pattern and timing of prebasic molt in adult Gray Catbirds (Dumetella carolinensis) at two New England sites: Block Island, Rhode Island (BIRI), and the Vermont Institute of Natural Science (VINS) in Woodstock, Vermont. Catbirds at VINS initiated molt earlier and molted at a significantly slower rate than catbirds at BIRI. Mean individual molt durations spanned approximately 54 days at VINS and 44 days at BIRI. The two groups ended molt at about the same time. Catbirds at VINS were more variable in the timing of their molt. At both sites, second-year catbirds began and ended molt significantly earlier than after second-year catbirds. Males and females did not differ significantly in their rate or timing of molt at either site. Behavioral observations at BIRI indicated that catbirds spent less time foraging during the heaviest period of molt, but that increased foraging during late molt stages coincided with increases in fat stores, indicating overlap of molt and hyperphagy. We found no evidence that Gray Catbirds at either site departed for migration prior to completing remigial molt. The later molt schedule of BIRI birds likely resulted from the extended breeding season of some individuals. We believe that molt schedules at the two sites were influenced less by latitude per se than by site-specific differences in vegetation, food abundance, and temperature, resulting from differing elevations and conditions of coastal and inland environments.
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Ristić, Milica. "Pojedini aspekti građanskopravnog položaja udatih žena u srednjovjekovnoj Engleskoj". Vesnik pravne istorije 1, n.º 2/2020 (15 de junho de 2021): 38–61. http://dx.doi.org/10.51204/hlh_20202a.
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The arrival of the Norman tribes in the territory of England inevitably meant the influence of the customs of these tribes on the formation of a new legal system, known as „common law”. Soon after, this system established the judicial precedent as the basic source of law, which made it significantly different from European continental legal systems. However, when it came to the position of women, the common law world was the same as the continental legal systems. It was the male world, as evidenced by the famous Blackstone’s thought that husband and wife are one, and that one is the husband. In the moment of marriage, the wife would lose her legal capacity, and her personality would be drowned in her husband’s power over her and her property. Considering many other restrictions on women’s rights that will be addressed in the paper, it is not surprising that widows enjoyed the best status in medieval England, mostly owing to the institute of dower. This injustice was corrected by the emergence of the justice system and especially the trust institute. This paper is dedicated to the stages of development of the rights of married women in medieval England from complete denial to their affirmation, and especially to the contribution of the institutions of equity law to that development.
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Kasten, Peggy. "Projects: Building Regional Capacity". Mathematics Teacher 93, n.º 6 (setembro de 2000): 536–38. http://dx.doi.org/10.5951/mt.93.6.0536.
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Building Regional Capacity (BRC) is an NSF-funded professional development institute for grades 7—12 mathematics teachers, department heads, mathematics coordinators, and other present or future teacher leaders from around New England. Its chief focus is leadership in designing and delivering quality professional development. BRC was developed at the Education Development Center (EDC) and is a collaboration among EDC, the University of Massachusetts Lowell (UMass Lowell), and the Eastern Massachusetts Association of Mathematics Department Heads.
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Angel, Jonathan B. "HIV Cure Research: An example of successful advocacy by scientists for science". Clinical and Investigative Medicine 41 (3 de novembro de 2018): 14–16. http://dx.doi.org/10.25011/cim.v41i2.31416.
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Following medical school and an internal medicine residency in Toronto, and infec-tious diseases training at the New England Medical Center/Tufts University in Boston, Jonathan joined the Division of Infectious Diseases, Department of Medicine at the Ottawa General Hospital in 1995. His research focuses on understanding how HIV damages the immune system and how these insights may lead to new therapies. Jon-athan is currently Professor of Medicine, University of Ottawa and Senior Scientist, Ottawa Hospital Research Institute. He was Editor-in-Chief of CIM from 2010–2015.
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Price, Christopher I., Phil White, Joyce Balami, Nawaraj Bhattarai, Diarmuid Coughlan, Catherine Exley, Darren Flynn et al. "Improving emergency treatment for patients with acute stroke: the PEARS research programme, including the PASTA cluster RCT". Programme Grants for Applied Research 10, n.º 4 (maio de 2022): 1–96. http://dx.doi.org/10.3310/tzty9915.
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Background Intravenous thrombolysis and intra-arterial thrombectomy are proven emergency treatments for acute ischaemic stroke, but they require rapid delivery to selected patients within specialist services. National audit data have shown that treatment provision is suboptimal. Objectives The aims were to (1) determine the content, clinical effectiveness and day 90 cost-effectiveness of an enhanced paramedic assessment designed to facilitate thrombolysis delivery in hospital and (2) model thrombectomy service configuration options with optimal activity and cost-effectiveness informed by expert and public views. Design A mixed-methods approach was employed between 2014 and 2019. Systematic reviews examined enhanced paramedic roles and thrombectomy effectiveness. Professional and service user groups developed a thrombolysis-focused Paramedic Acute Stroke Treatment Assessment, which was evaluated in a pragmatic multicentre cluster randomised controlled trial and parallel process evaluation. Clinicians, patients, carers and the public were surveyed regarding thrombectomy service configuration. A decision tree was constructed from published data to estimate thrombectomy eligibility of the UK stroke population. A matching discrete-event simulation predicted patient benefits and financial consequences from increasing the number of centres. Setting The paramedic assessment trial was hosted by three regional ambulance services (in north-east England, north-west England and Wales) serving 15 hospitals. Participants A total of 103 health-care representatives and 20 public representatives assisted in the development of the paramedic assessment. The trial enrolled 1214 stroke patients within 4 hours of symptom onset. Thrombectomy service provision was informed by a Delphi exercise with 64 stroke specialists and neuroradiologists, and surveys of 147 patients and 105 public respondents. Interventions The paramedic assessment comprised additional pre-hospital information collection, structured hospital handover, practical assistance up to 15 minutes post handover, a pre-departure care checklist and clinician feedback. Main outcome measures The primary outcome was the proportion of patients receiving thrombolysis. Secondary outcomes included day 90 health (poor status was a modified Rankin Scale score of > 2). Economic outputs reported the number of cases treated and cost-effectiveness using quality-adjusted life-years and Great British pounds. Data sources National registry data from the Sentinel Stroke National Audit Programme and the Scottish Stroke Care Audit were used. Review methods Systematic searches of electronic bibliographies were used to identify relevant literature. Study inclusion and data extraction processes were described using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results The paramedic assessment trial found a clinically important but statistically non-significant reduction in thrombolysis among intervention patients, compared with standard care patients [197/500 (39.4%) vs. 319/714 (44.7%), respectively] (adjusted odds ratio 0.81, 95% confidence interval 0.61 to 1.08; p = 0.15). The rate of poor health outcomes was not significantly different, but was lower in the intervention group than in the standard care group [313/489 (64.0%) vs. 461/690 (66.8%), respectively] (adjusted odds ratio 0.86, 95% confidence interval 0.60 to 1.2; p = 0.39). There was no difference in the quality-adjusted life-years gained between the groups (0.005, 95% confidence interval –0.004 to 0.015), but total costs were significantly lower for patients in the intervention group than for those in the standard care group (–£1086, 95% confidence interval –£2236 to –£13). It has been estimated that, in the UK, 10,140–11,530 patients per year (i.e. 12% of stroke admissions) are eligible for thrombectomy. Meta-analysis of published data confirmed that thrombectomy-treated patients were significantly more likely to be functionally independent than patients receiving standard care (odds ratio 2.39, 95% confidence interval 1.88 to 3.04; n = 1841). Expert consensus and most public survey respondents favoured selective secondary transfer for accessing thrombectomy at regional neuroscience centres. The discrete-event simulation model suggested that six new English centres might generate 190 quality-adjusted life-years (95% confidence interval –6 to 399 quality-adjusted life-years) and a saving of £1,864,000 per year (95% confidence interval –£1,204,000 to £5,017,000 saving per year). The total mean thrombectomy cost up to 72 hours was £12,440, mostly attributable to the consumables. There was no significant cost difference between direct admission and secondary transfer (mean difference –£368, 95% confidence interval –£1016 to £279; p = 0.26). Limitations Evidence for paramedic assessment fidelity was limited and group allocation could not be masked. Thrombectomy surveys represented respondent views only. Simulation models assumed that populations were consistent with published meta-analyses, included limited parameters reflecting underlying data sets and did not consider the capital costs of setting up new services. Conclusions Paramedic assessment did not increase the proportion of patients receiving thrombolysis, but outcomes were consistent with improved cost-effectiveness at day 90, possibly reflecting better informed treatment decisions and/or adherence to clinical guidelines. However, the health difference was non-significant, small and short term. Approximately 12% of stroke patients are suitable for thrombectomy and widespread provision is likely to generate health and resource gains. Clinician and public views support secondary transfer to access treatment. Future work Further evaluation of emergency care pathways will determine whether or not enhanced paramedic assessment improves hospital guideline compliance. Validation of the simulation model post reconfiguration will improve precision and describe wider resource implications. Trial registration This trial is registered as ISRCTN12418919 and the systematic review protocols are registered as PROSPERO CRD42014010785 and PROSPERO CRD42015016649. Funding The project was funded by the National Institute for Health and Care Research (NIHR) Programme Grants for Applied Research programme and will be published in full in Programme Grants for Applied Research; Vol. 10, No. 4. See the NIHR Journals Library website for further project information.
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Lux-Sterritt, Laurence. "An Analysis of the Controversy Caused by Mary Ward’s Institute in the 1620s". Recusant History 25, n.º 4 (outubro de 2001): 636–47. http://dx.doi.org/10.1017/s0034193200030521.
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During the reign of Elizabeth I, English Catholicism experienced a degree of persecution that was meant to ensure the extirpation of the old faith. However, Elizabethan anti-Catholic laws had an ambiguous effect upon the recusant population of England. Although the Roman Catholic faith initially suffered greatly, yet by the end of the reign it was rising again with force. The unique vocation of Yorkshirewoman, Mary Ward (1585–1645), can be seen as an eloquent illustration of this new English Catholic spirit and as the embodiment of an English missionary determination to further the Catholic cause.
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Davie, Laura, Alison Rataj, Beth Dugan, Renee Pepin, Josephine Porter, Jennifer Rabalais e Matha Tecca. "Measuring Age-Friendly Communities in New England: Promising Pilot From the New Hampshire Alliance for Healthy Aging". Innovation in Aging 4, Supplement_1 (1 de dezembro de 2020): 51. http://dx.doi.org/10.1093/geroni/igaa057.167.
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Abstract The New Hampshire Alliance for Healthy Aging is a statewide coalition building partnerships that support and promote healthy aging throughout the state. Through a collective impact approach, six domains (fundamental needs, living arrangements, caregiver support, social and civic engagement, physical and mental wellbeing, and advocacy) were defined to characterize and support the ongoing evaluation of age friendly communities. This poster describes a measurement framework and the development of a strategy to support gathering data across northern New England. A committee of state and national experts has convened to identify the best available indicators and measures for each of the domains and to expose gaps in available data. Representation includes individuals representing the University of New Hampshire, Tri-State Learning Collaborative on Aging (TSLCA), UMass Boston’s Department of Gerontology, and the 100 Million Healthier Lives Initiative (Institute of Healthcare Improvement). Researchers scanned national and state level sources for credibility, consistency, and availability of comparison information. Across the six domains, 43 indicators were selected. 26 did not have available data. Factors measuring social determinants of health are central and especially difficult to quantify, demanding new strategies and data collection approaches. Funding is essential for efforts to define and pilot a new data module to capture a broader set of meaningful data to measure and evaluate age friendly communities. Comprised of grassroots efforts across the fastest aging region of the country, Northern New England, under the Tri-State Learning Collaborative on Aging, is a prime location to use as a pilot project for this module.
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Bee, Charlotte, Claire Hawksworth, Leanne Wakefield e Brad Groves. "OP38 Managed (Early) Access In England: The ‘Ins And Outs’". International Journal of Technology Assessment in Health Care 38, S1 (dezembro de 2022): S16. http://dx.doi.org/10.1017/s0266462322000952.
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IntroductionManaged access approaches have been used by The National Institute for Health and Care Excellence (NICE) in partnership with NHS England since 2015. The Cancer Drugs Fund is an exemplar of this approach which enables earlier patient access to promising new treatments while further real-world data is collected to address evidential uncertainties. Increasingly, this approach is being applied to rare diseases and other conditions to address unmet clinical need with extensive involvement from patient organizations and clinicians.MethodsAll Managed Access Agreements (MAAs) in development or published in England were reviewed to present data on the number of technologies (i) entering, (ii) in active monitoring, and (iii) exiting managed access, for both cancer and other disease areas.ResultsAfter six years since the first MAA (at December 2021), over 73,000 patients have benefited from earlier access to promising new treatments for cancer, genetic and rare diseases, including cystic fibrosis, spinal muscular atrophy and sickle cell disease via managed access. Fifty-eight technologies were commissioned via managed access: thirty technologies in active data collection, eleven technologies being re-evaluated, and seventeen technologies have exited managed access. Patient and clinical engagement have been essential to the successful real-world data collections delivered and underway.ConclusionsManaged access is an approach for providing earlier patient access to promising new technologies that would not otherwise be recommended for use in England. The approach to managed access in England is maturing at the same time the volume of topics entering and exiting managed access in England is expected to grow throughout 2022 with the introduction of the Innovative Medicines Fund.
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Beal, Jane. "Michael Clanchy. Looking Back from the Invention of Printing: Mothers and the Teaching of Reading in the Middle Ages. Turnhout: Brepols, 2018, 211 pp." Mediaevistik 32, n.º 1 (1 de janeiro de 2020): 467–69. http://dx.doi.org/10.3726/med.2019.01.121.
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Michael Clanchy (Professor Emeritus of Medieval History at the Institute of Historical Research, University of London and Fellow of the British Academy), who is well-known for his seminal study From Memory to Written Record: England, 1066–1307 (1979; rev. 1993; Oxford, rev. 2013), has produced a new book with an original introduction that brings together six of his studies, all previously published separately in edited collections between 1983 and 2011. The book concerns a significant theme: the development of literacy in later medieval England and Europe. The chapters explore the evidence from medieval manuscripts and material culture, especially visual art, to provide support for the idea that mothers taught their children the basics of reading before taking them to school. Clanchy writes:
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Landells, Linda, Martyn Burke e Meindert Boysen. "OP02 A Managed Access Approach To Appraising New Cancer Drugs In England". International Journal of Technology Assessment in Health Care 33, S1 (2017): 1–2. http://dx.doi.org/10.1017/s0266462317001131.
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INTRODUCTION:The changing regulatory landscape brings new challenges to Health Technology Assessment (HTA). Marketing authorizations are being granted as the evidence base evolves to facilitate timely patient access to promising health technologies. Consequently, some products come to HTA bodies sooner in their development cycles with less evidence, which ultimately leads to greater uncertainty in decision making. A key challenge for payer and HTA bodies is providing access to promising medicines while the evidence is still emerging, in a financially sustainable way.METHODS:Changes to the Cancer Drugs Fund (CDF) have resulted in a managed access fund for cancer medicines in England. The National Institute for Health and Care Excellence (NICE) can now recommend a treatment for use within the CDF if there is plausible potential to satisfy the criteria for routine use in the National Health Service (NHS) at its current price, but the evidence is not robust enough and associated with significant uncertainty. Further evidence is then generated in clinical trials, through observational data collection, or a combination of the two, while the drug's price reflects the decision uncertainty. At the end of the managed access period, NICE reviews the guidance to determine if the treatment can be recommended for routine commissioning.RESULTS:The first treatment recommended for use within the new CDF was osimertinib for non-small cell lung cancer (1). At the time of NICE appraisal, there was considerable uncertainty in osimertinib's clinical and cost effectiveness because only short-term phase II trial results were available. NICE's independent appraisal committee considered there was plausible potential for osimertinib to be cost effective and identified that an ongoing phase III trial would provide longer-term data addressing the key uncertainties.CONCLUSIONS:An integrated approach between payer and HTA decision-maker has significantly changed how cancer treatments in England are appraised. This collaborative way of working heralds a more sustainable approach to introducing promising cancer treatments.
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Johnson, J. W. "Complete Proceedings - Single PDF Download". Coastal Engineering Proceedings 1, n.º 3 (1 de janeiro de 2000): 0. http://dx.doi.org/10.9753/icce.v3.0.
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This conference was sponsored jointly by the Council on Wave Research and the Massachusetts Institute of Technology, with support also being given by the Northeastern Section of the American Society of Civil Engineers, the Boston Society of Civil Engineers and the Boston Section of the American Society of Mechanical Engineers. Appreciation is expressed to the New England Division of the Corps of Engineers for photographs supplied to illustrate the cover and the section titles of this publication.
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Watts, Harold W. "Distinguished Fellow: An Appreciation of Guy Orcutt". Journal of Economic Perspectives 5, n.º 1 (1 de fevereiro de 1991): 171–79. http://dx.doi.org/10.1257/jep.5.1.171.
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Guy Henderson Orcutt, Distinguished Fellow of our Association. has now moved to a new phase of his career (retirement). Most of Guy's career has been at four universities: Michigan, where he earned all three degrees, Harvard, Wisconsin, and Yale. In between, he spent periods at MIT, Cambridge University in England, the International Monetary Fund, the World Bank, and The Urban Institute. To me, Guy is several persons rolled into one: inventor, visionary, empiricist, mentor, and friend.
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DuBuske, Lawrence M. "Introduction: Mediator Assays and Inflammatory Events in Asthma and Allergic Disease: (Immunology Research Institute of New England Symposium)". Allergy and Asthma Proceedings 15, n.º 3 (1 de maio de 1994): 115–17. http://dx.doi.org/10.2500/108854194778702928.
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Davids, Femke. "Hurricane activity during the late Holocene in New England, USA, based on optical dating". Quaternary International 279-280 (novembro de 2012): 107. http://dx.doi.org/10.1016/j.quaint.2012.07.475.
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WENDEHORST, STEPHAN. "LIBERALISM, NATIONALISM AND RACISM: AMBIVALENT SIGNATURES OF MODERNITY". Historical Journal 40, n.º 2 (junho de 1997): 557–63. http://dx.doi.org/10.1017/s0018246x96007133.
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Nazism and German society. 1933–1945. Edited by David F. Crew. (Rewriting Histories.) London/New York: Routledge, 1994. Pp. xi + 316. £11.99.The Holocaust and the liberal imagination. A social and cultural history. By Tony Kushner. (Jewish Society and Culture.) Oxford/Cambridge: Blackwell, 1994. Pp. xx + 366. £14.99.The Zionist ideology. By Gideon Shimoni. (The Tauber Institute for the Study of European Jewry Series, 21.) Hanover/London: University Press of New England for Brandeis University Press, 1995. Pp. xvi + 506. £46.95.American Zionism from Herzl to the Holocaust. By Melvin I. Urofsky. Lincoln/London: University of Nebraska Press, 1995. Pp. xv + 538. $15.00.
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Eaton, Georgette, Kamal Mahtani e Matt Catterall. "The evolving role of paramedics – a NICE problem to have?" Journal of Health Services Research & Policy 23, n.º 3 (23 de abril de 2018): 193–95. http://dx.doi.org/10.1177/1355819618768357.
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This short essay supports the growing role of paramedics in the clinical and academic workforce. We present a commentary of recent draft consultations by the National Institute for Health and Care Excellence in England that set out how the role of paramedics may be evolving to assist with the changing demands on the clinical workforce. Using these consultations as a basis, we extend their recommendations and suggest that the profession should also lead the academically driven evaluation of these new roles.
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Raimundo Jr, Ivo. "Professor Ivo M. Raimundo Jr., a researcher concerned about the current state of science in Brazil, kindly granted BrJAC an interview". Brazilian Journal of Analytical Chemistry 10, n.º 39 (4 de abril de 2023): 3–8. http://dx.doi.org/10.30744/brjac.2179-3425.interview.ivo.raimundo.
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Ivo M. Raimundo Jr. holds a degree in chemistry (1983), a master’s degree in chemistry (1989), and a doctorate in analytical chemistry (1995), all from the Institute of Chemistry, University of Campinas (IQ-Unicamp), Brazil. He carried out postdoctoral studies at the University of Manchester Institute of Science and Technology (UMIST), Manchester, England (1997/98), and the University of South Carolina, Columbia, USA (2017). He is currently Associate Professor at the Department of Analytical Chemistry at IQ - Unicamp. He was Associate Director (2006–2009) and Director (2009–2015) of the Pluridisciplinary Center for Chemical, Biological and Agricultural Research (CPQBA) at Unicamp, Secretary of the Brazilian Chemical Society, Campinas Regional (2020-2022) and is currently its treasurer. He has served as an Associate Editor of the Journal of the Brazilian Chemical Society since 2019. Prof. Raimundo Jr has experience in instrumentation and automation in analytical chemistry, working mainly in the following areas: optical (nano)sensors, microfabrication of analytical systems, and laser-induced breakdown spectroscopy (LIBS).
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Turkstra, Erika, Lok Wan Liu, Silvy Mardiguian e Sangeeta Budhia. "OP20 Has The New HST Process Improved The Recommendation Chance In England?" International Journal of Technology Assessment in Health Care 35, S1 (2019): 4. http://dx.doi.org/10.1017/s0266462319000928.
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IntroductionThe National Institute for Health and Care Excellence (NICE) in England has a separate appraisal process for drugs for very rare conditions, i.e. Highly Specialised Therapies (HST). In April 2017, the HST process has been changed to incorporate a quantitative approach: automatically fund treatments with incremental cost-effectiveness ratio (ICERs) up to GBP 100,000 (EUR 113,008 based on the 2018 average GBP / EUR exchange rate) per quality-adjusted life year (QALY). For treatments with an ICER above GBP 100,000 per QALY, NICE will consider treatments that offer a substantial magnitude of improvement, with additional QALY weighting. We investigated the impact of this more quantitative approach on the likelihood of a HST receiving a positive recommendation.MethodsAll HST appraisals and draft guidance documents were reviewed (up to November 2018) and data were extracted on ICERs, incremental QALY gain, budget impact, and recommendations. The extracted data from each HST were assessed based on the interim HST guidance.ResultsEighteen products have been or are currently going through the NICE HST process. Of these, 8/18 (44%) have received a positive recommendation, while 5/18 (28%) have received a draft negative guidance, and for 5/18 (28%) products, no recommendations have been published. For the products with a positive outcome, 5/8 (63%) had incremental QALY gain of at least 10, qualifying these products for additional QALY weighting. For the products that received a draft negative recommendation, the negative decision was related to the cost-effectiveness estimates being higher than GBP 100,000 per QALY (5/5 reported) in all cases, while none of these products were eligible to receive a ‘QALY modifier’.ConclusionsIt has become more difficult for HSTs to get recommended by NICE under the new guidance, which requires cost-effectiveness analyses, whereas previously there was no official ICER threshold. The additional weighting of QALYs may be insufficient to meet an ICER threshold of GBP 100,000 per QALY for many products.
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Liscombe, R. W. "A "New Era in My Life": Ithiel Town Abroad". Journal of the Society of Architectural Historians 50, n.º 1 (1 de março de 1991): 5–17. http://dx.doi.org/10.2307/990542.
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Ithiel Town traveled twice to England and Europe, intent on studying "improvements in the taste and science of architecture" and "bridge engineering." His first tour, between October 1829 and July 1830, preceded the zenith of his career. It can be retraced in a series of largely unpublished letters addressed to his daughter, Etha, and his partner, Alexander Jackson Davis. The correspondence relates Town's immediate reactions and, hence, taste; his contact with the artistic community in London, including such fellow American visitors as S. F. B. Morse, whom he accompanied to Rome; and his purchase of books and prints, which he later housed in the fireproof villa he built in New Haven between 1834 and 1836. The major legacy of his study was a deepened appreciation of historical architecture and an evident objective not of imitating specific historical works but of enhancing the scale and sophistication of his own design. He was also inspired to seek improved educational facilities and status for the profession in the United States, participating in the foundation of the short-lived American Institution of Architects. He maintained links with leading figures in the British architectural scene, being among the earliest nonresident members elected to the newly founded Institute of British Architects in 1836. The value he attached to his first tour was confirmed when, in July 1843, Town again crossed the Atlantic to examine recent developments and design, mainly in England and Paris, the effect of which was unfortunately curtailed by his death some six months after his return to New York in December 1843.
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Whitburn, Jessica, Surjeet Singh e Prasanna Sooriakumaran. "Setting up clinical research studies in the National Health Service in England". Journal of Clinical Urology 10, n.º 2 (9 de julho de 2016): 145–47. http://dx.doi.org/10.1177/2051415816657764.
Texto completo da fonteResumo:
Starting and conducting clinical trials in England can be a complicated and time-consuming process. Before your study can begin it is necessary to gain approval from the appropriate regulatory bodies. Prior to March 2016, studies required National Health Service (NHS) permission (also referred to as Research and Development (R&D) approval) obtained via the National Institute for Health Research (NIHR) Coordinated System for gaining NHS Permission (CSP). Since March 2016, a new streamlined system has been introduced with the aim of making it easier to gain regulatory approvals. Now studies must go through the process of Health Research Authority (HRA) approval. In this article we review the process of gaining HRA approval in England. The article is aimed at junior researchers to help them understand the application process, and to give tips on how to succeed in gaining approval.
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Pfister, S. E., S. Halik e D. R. Bergdahl. "Dothistroma Needle Blight, Caused by Dothistroma septospora, of Pinus spp. in Vermont". Plant Disease 84, n.º 6 (junho de 2000): 706. http://dx.doi.org/10.1094/pdis.2000.84.6.706d.
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Dothistroma needle blight, caused by Dothistroma septospora (teleo-morph Mycosphaerella pini), is a serious foliage disease of pine species throughout the world. In the northeastern United States, the fungus has been reported from Pennsylvania, but not New York, New Jersey, or any of the New England states. It has been reported from the eastern provinces of Canada (Newfoundland, Quebec). During 1994 to 1998, stromatic conidomata consistent with descriptions of D. septospora were associated with needle blight symptoms on mature landscape pines at four locations (Jericho, Montpelier, Williamstown, Williston) and one Christmas tree farm (Barre) in Vermont. Pinus nigra was affected at four locations; P. mugo and P. ponderosa were affected at one location each. Severe foliar blight and defoliation occurred during successive years on P. nigra and P. mugo. Collections from each location and host were examined microscopically. Mean lengths and widths of 20 or more conidia from each of three collections of P. nigra (Barre, Montpelier, and Williston) were 2.3 × 25, 2.7 × 20, and 2.6 × 24 μm, respectively. Corresponding values for collections from P. mugo and P. ponderosa were 2.4 × 26 and 3.6 × 31 μm, respectively. All collections conformed to descriptions and illustrations of D. septospora (1). No ascigerous state was observed from 1994 to 1998. This is the first report of D. septospora in New England. Reference: (1) H. C. Evans. 1984. The Genus Mycosphaerella and Its Anamorphs Cercoseptoria, Dothistroma and Lecanosticta on Pines. Commonwealth Mycological Institute, Kew, England.
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Ladyka, V. I., Yu I. Sklyarenko e Yu M. Pavlenko. "FORMATION OF ECONOMICALLY USEFUL TRAITS IN COWS OF UKRAINIAN BROWN DAIRY BREED OF DIFFERENT GENOTYPES BY KAPPA-CASEIN". Animal Breeding and Genetics 63 (9 de agosto de 2022): 161–68. http://dx.doi.org/10.31073/abg.63.15.
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The genes of cattle casein are polymorphic. Today, a large number of variants of kappa-casein protein are known:
A, B, B2, C, D, E, F1, F2, G1, G2, H, I і J. Scientists pay attention to three main types of genotypes – AA, AB and BB. It has been proven that the most common alleles of kappa-casein in cattle are A and B. Importantly, the allelic variant of kappa-casein B is associated with the production of milk with a more optimal chemical composition and technological parameters for cheese production compared to the A allele.
According to the results of scientific research, it was established that the level of milk yield in cows with the AA genotype was higher compared to animals of other genotypes. At the same time, animals with the BB genotype are characterized by a higher protein content in milk compared to milk from animals with the AA genotype. Scientists have also proven that the milk of animals with the desired genotype (BB) curdles faster during cheese production, and the yield of cheese is higher than that of animals with the AA genotype. In confirmation of this, other researchers note that animals with the AA genotype have a lower average protein content in milk (by 0.09%) compared to animals with the BB genotype.
The purpose of the study is to establish the influence of kappa-casein genotypes on economic and useful traits of animals of Ukrainian Brown Dairy breed.
Research materials and methods. Genotyping of 42 heads of Ukrainian Brown Dairy breed cattle belonging to the Breeding Plant of the State Enterprise "Experimental Farm of Institute of Agriculture of Northern East of NAAS" was carried out. Determination of kappa-casein gene polymorphism was carried out in the genetic laboratory of the Institute of Physiology named after Bogomolets of NAS with the help of molecular biological analysis of allele recognition by polymerase chain reaction (PCR) in real time.
Blood samples were collected in monovets with a volume of 2.7 ml (Sarstedt, Germany), with subsequent freezing of the samples and their storage at -20ºC. DNA for genotyping was obtained from samples using the Monarch® New England BioLab (USA) genomic DNA purification kit according to the manufacturer's protocol.
Three sub-experimental groups of Ukrainian Brown Dairy breed animals with genotypes according to kappa-casein AA, AB and BB were formed. The electronic database of SUMS "Orsek" was used to evaluate economic and useful features. Changes in live weight of cattle up to 18 months of age, indicators of reproductive capacity, and milk productivity were evaluated. The research results were processed using the methods of mathematical statistics using the "Statistica-6.1" package in the Windows environment on a personal computer.
As a result of the conducted research, no significant influence of the kappa-casein genotype on live weight indicators of heifers was established in all studied periods. This indicates that when creating herds of animals with the desired BB genotype, the growth indicators of repair heifers will not deteriorate.
According to indicators of reproductive capacity, there is no statistically significant difference between animals of different genotypes. At the same time, the youngest age of first insemination was distinguished by animals with the AB genotype, and the highest – with the AA genotype. The duration of the intercalving period and the value of the coefficient of reproductive capacity were the lowest in homozygous (AA) and heterozygous (AB) animals.
During the first lactation, homozygous AA animals had an advantage in the content of fat and protein in milk. Homozygous BB cows had an advantage in terms of milk yield in the third lactation, in terms of fat content – animals with heterozygous genotype AB, protein – animals with genotype AA. In terms of better lactation, animals with the BB genotype prevailed over other groups in terms of milk yield. Homozygous AA animals had an advantage in terms of fat content, and homozygous BB animals had an advantage in terms of protein content.
Conclusions. Animals of the Ukrainian Brown Dairy breed corresponded to the standard of the breed in almost all indicators of milk productivity. Between animals of different genotypes, according to kappa-casein, a difference was established for certain economic and useful traits. It should be noted that in different periods and according to different characteristics, it varied greatly, and in some cases it was statistically significant. In the third and best lactation according to milk yield, a statistically significant difference was established between homozygous BB, heterozygous AB genotypes and homozygous AA in favor of the first two genotypes. It can be stated that the formation of herds with the BB genotype for kappa-casein will ensure the preservation of the desired values of productive indicators of dairy cattle.