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1

Mattsson-Carlgren, Niklas, Lea T. Grinberg, Adam Boxer, et al. "Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration." Neurology 98, no. 11 (2022): e1137-e1150. http://dx.doi.org/10.1212/wnl.0000000000200040.

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Background and ObjectivesTo determine how fully automated Elecsys CSF immunoassays for β-amyloid (Aβ) and tau biomarkers and an ultrasensitive Simoa assay for neurofilament light chain (NFL) correlate with neuropathologic changes of Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD).MethodsWe studied 101 patients with antemortem CSF and neuropathology data. CSF samples were collected a mean of 2.9 years before death (range 0.2–7.5 years). CSF was analyzed for Aβ40, Aβ42, total tau (T-tau), tau phosphorylated at amino acid residue 181 (P-tau), P-tau/Aβ42 and Aβ42/Aβ40 ratios, a
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2

Wallace, Lindsay M. K., Olga Theou, Sultan Darvesh, et al. "Neuropathologic burden and the degree of frailty in relation to global cognition and dementia." Neurology 95, no. 24 (2020): e3269-e3279. http://dx.doi.org/10.1212/wnl.0000000000010944.

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ObjectiveTo test the hypothesis that degree of frailty and neuropathologic burden independently contribute to global cognition and odds of dementia.MethodsThis was a secondary analysis of a prospective cohort study of older adults living in Illinois. Participants underwent an annual neuropsychological and clinical evaluation. We included 625 participants (mean age 89.7 ± 6.1 years; 67.5% female) who died and underwent autopsy. We quantified neuropathology using an index measure of 10 neuropathologic features: β-amyloid deposition, hippocampal sclerosis, Lewy bodies, tangle density, TDP-43, cer
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3

Blackburn, Jessica, Diana L. Thomas, Anna Hughes, and Christopher R. Pierson. "Neuropathology of Septo-optic Dysplasia: A Report of 4 Autopsy Cases." Journal of Child Neurology 36, no. 2 (2020): 105–15. http://dx.doi.org/10.1177/0883073820954071.

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Septo-optic dysplasia (SOD) is defined by the presence of 2 or more features in a diagnostic triad: (1) optic nerve hypoplasia, (2) pituitary dysfunction, and (3) midline forebrain anomalies. SOD arises due to diverse pathogenetic mechanisms including acquired and genetic factors, and it shows considerable clinical and phenotypic variability. Our knowledge of SOD is incomplete in part because of a paucity of published neuropathology data, so we reviewed the autopsy neuropathology of 4 SOD patients. All patients met SOD criteria according to the triad. Additional neuropathologic findings includ
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4

Saito, Yuko, and Shigeo Murayama. "Neuropathology." Rinsho Shinkeigaku 51, no. 11 (2011): 1168–71. http://dx.doi.org/10.5692/clinicalneurol.51.1168.

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5

Squier, M. V. "Neuropathology." AVMA Medical & Legal Journal 2, no. 2 (1996): 37–42. http://dx.doi.org/10.1177/135626229600200202.

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6

Hart, Michael N. "Neuropathology." Journal of Neuropathology and Experimental Neurology 64, no. 10 (2005): 923. http://dx.doi.org/10.1097/01.jnen.0000182984.87106.1f.

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7

Tremblay, G. F. "Neuropathology." Neurology 39, no. 2 (1989): 313. http://dx.doi.org/10.1212/wnl.39.2.313.

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8

Almira-Suarez, Maria Isabel, and Maria Beatriz Lopes. "Neuropathology." American Journal of Surgical Pathology 37, no. 11 (2013): 1768. http://dx.doi.org/10.1097/pas.0000000000000084.

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9

Pinckard, J. Keith. "Neuropathology." Academic Forensic Pathology 2, no. 1 (2012): vi—vii. http://dx.doi.org/10.1177/192536211200200101.

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10

Renshaw, Andrew. "Neuropathology." Advances in Anatomic Pathology 13, no. 1 (2006): 62. http://dx.doi.org/10.1097/01.pap.0000201830.69849.b9.

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11

Mischel, Paul S., and Harry V. Vinters. "Neuropathology." Neurosurgery Clinics of North America 6, no. 3 (1995): 565–80. http://dx.doi.org/10.1016/s1042-3680(18)30450-9.

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12

Tihan, Tarik. "Neuropathology." Surgical Pathology Clinics 8, no. 1 (2015): i. http://dx.doi.org/10.1016/s1875-9181(15)00004-5.

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13

Ng, Thomas H. K. "Neuropathology." Pathology 31, no. 4 (1999): 442. http://dx.doi.org/10.1016/s0031-3025(16)34759-6.

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14

Dayan, A. "Neuropathology." Journal of Clinical Pathology 42, no. 3 (1989): 334. http://dx.doi.org/10.1136/jcp.42.3.334-b.

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15

Timperley, W. R. "Neuropathology." Journal of Clinical Pathology 53, no. 4 (2000): 255–65. http://dx.doi.org/10.1136/jcp.53.4.255.

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16

Reifenberger, G., and J. Bell. "Neuropathology." Journal of Neurovirology 8, no. 3 (2002): 26–27. http://dx.doi.org/10.1080/13550280290049886.

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17

Fazakerley, J., and E. Neuen-Jacob. "Neuropathology." Journal of Neurovirology 8, no. 3 (2002): 71–78. http://dx.doi.org/10.1080/13550280290050064.

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18

ALVORD, ELLSWORTH C., and JOSEPH R. SIEBERT. "Neuropathology." Journal of Neuropathology and Experimental Neurology 56, no. 12 (1997): 1373–74. http://dx.doi.org/10.1097/00005072-199712000-00014.

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19

Garcia, Julio. "Neuropathology." Journal of Neuropathology and Experimental Neurology 57, no. 2 (1998): 203. http://dx.doi.org/10.1097/00005072-199802000-00011.

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20

Lowe, J. "Neuropathology." Journal of Pathology 168, no. 2 (1992): 249–53. http://dx.doi.org/10.1002/path.1711680215.

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21

Swerdlow, Neal R., and Anne B. Young. "Neuropathology in Tourette Syndrome." CNS Spectrums 4, no. 3 (1999): 65–74. http://dx.doi.org/10.1017/s1092852900000833.

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ABSTRACTThe unique clinical presentation of Tourette syndrome (TS) and its symptomatic response to dopamine antagonists are widely cited as evidence for the central role of the limbic-motor interface in the pathophysiology of TS. Nonetheless, the true neuropathology of TS remains elusive, even though significant advances have been made in understanding complex interconnected circuitries within the limbic system and basal ganglia. Neuropathologic and neuroimaging studies—plagued by small samples, clinical heterogeneity, and a number of interpretative problems—are generally supportive of patholo
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22

Graham, Eileen K., Bryan D. James, Kathryn L. Jackson, et al. "Associations Between Personality Traits and Cognitive Resilience in Older Adults." Journals of Gerontology: Series B 76, no. 1 (2020): 6–19. http://dx.doi.org/10.1093/geronb/gbaa135.

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Abstract Objectives The goal of this paper was to examine associations between personality traits and resilience to neuropathologic burden. Method Using data from the Religious Orders Study and the Rush Memory and Aging Project, we identified a total of 1,375 participants with personality, cognitive, and post-mortem neuropathology data. We regressed cognition onto pathology and extracted the residuals as an indicator of cognitive resilience. We then modeled the effect of Big Five personality traits on cognitive resilience, adjusting for demographics, APOE status, medical comorbidities, and cog
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23

Henriksen, Jonathan, Teresa Kolognizak, Tracy Houghton, et al. "Rapid Validation of Telepathology by an Academic Neuropathology Practice During the COVID-19 Pandemic." Archives of Pathology & Laboratory Medicine 144, no. 11 (2020): 1311–20. http://dx.doi.org/10.5858/arpa.2020-0372-sa.

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Context.— The coronavirus disease 19 (COVID-19) pandemic is placing unparalleled burdens on regional and institutional resources in medical facilities across the globe. This disruption is causing unprecedented downstream effects to traditionally established channels of patient care delivery, including those of essential anatomic pathology services. With Washington state being the initial North American COVID-19 epicenter, the University of Washington in Seattle has been at the forefront of conceptualizing and implementing innovative solutions in order to provide uninterrupted quality patient c
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24

Shaffer, Rachel M., Ge Li, Sara D. Adar, et al. "Fine Particulate Matter and Markers of Alzheimer’s Disease Neuropathology at Autopsy in a Community-Based Cohort." Journal of Alzheimer's Disease 79, no. 4 (2021): 1761–73. http://dx.doi.org/10.3233/jad-201005.

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Background: Evidence links fine particulate matter (PM2.5) to Alzheimer’s disease (AD), but no community-based prospective cohort studies in older adults have evaluated the association between long-term exposure to PM2.5 and markers of AD neuropathology at autopsy. Objective: Using a well-established autopsy cohort and new spatiotemporal predictions of air pollution, we evaluated associations of 10-year PM2.5 exposure prior to death with Braak stage, Consortium to Establish a Registry for AD (CERAD) score, and combined AD neuropathologic change (ABC score). Methods: We used autopsy specimens (
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25

Paradise, Matthew B., Claire E. Shepherd, Wei Wen, and Perminder S. Sachdev. "Neuroimaging and neuropathology indices of cerebrovascular disease burden." Neurology 91, no. 7 (2018): 310–20. http://dx.doi.org/10.1212/wnl.0000000000005997.

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ObjectiveTo systematically review the literature on the use of both neuroimaging and neuropathologic indices of cerebrovascular disease (CVD) burden, as estimation of this burden could have multiple benefits in the diagnosis and prognosis of cognitive impairment and dementia.MethodsMEDLINE and EMBASE databases were searched (inception to June 2017) to obtain and then systematically review all pertinent neuroimaging and neuropathology studies, where an index of CVD was developed or tested.ResultsTwenty-five neuroimaging articles were obtained, which included 4 unique indices. These utilized a l
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26

Misser, S. K., and J. F. Roos. "Paediatric neuropathology." South African Journal of Radiology 15, no. 3 (2011): 101. http://dx.doi.org/10.4102/sajr.v15i3.381.

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27

Shankar, SK. "Neuropathology series." Annals of Indian Academy of Neurology 10, no. 2 (2007): 68. http://dx.doi.org/10.4103/0972-2327.33212.

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28

Squier, Marian V. "The Neuropathology." AVMA Medical & Legal Journal 4, no. 3 (1998): 81–88. http://dx.doi.org/10.1177/135626229800400304.

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29

Moore, Josephine C. "Neonatal Neuropathology." Physical & Occupational Therapy In Pediatrics 6, no. 3-4 (1986): 55–90. http://dx.doi.org/10.1080/j006v06n03_03.

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30

Hart, Michael N. "Developmental Neuropathology." Journal of Neuropathology & Experimental Neurology 64, no. 7 (2005): 648. http://dx.doi.org/10.1097/01.jnen.0000171655.62954.f6.

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31

Lantos, P. "Diagnostic Neuropathology." Journal of Neurology, Neurosurgery & Psychiatry 52, no. 9 (1989): 1120. http://dx.doi.org/10.1136/jnnp.52.9.1120-a.

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32

Janota, I. "Greenfield's Neuropathology." Journal of Clinical Pathology 46, no. 1 (1993): 95–96. http://dx.doi.org/10.1136/jcp.46.1.95-f.

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33

Geddes, J. F. "Greenfield's Neuropathology." Journal of Clinical Pathology 50, no. 9 (1997): 798. http://dx.doi.org/10.1136/jcp.50.9.798-a.

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34

Robson, Keith. "Neuropathology Techniques." Neuropathology and Applied Neurobiology 31, no. 2 (2005): 204–5. http://dx.doi.org/10.1111/j.1365-2990.2005.00585.x.

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35

Mazanti, I. "Forensic Neuropathology." Neuropathology and Applied Neurobiology 33, no. 3 (2007): 364–66. http://dx.doi.org/10.1111/j.1365-2990.2007.00808.x.

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36

&NA;, &NA;. "Neuropathology Review." American Journal of Surgical Pathology 17, no. 12 (1993): 1303. http://dx.doi.org/10.1097/00000478-199312000-00015.

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37

Moore, Josephine. "Neonatal Neuropathology." Physical & Occupational Therapy In Pediatrics 6, no. 3 (1986): 55–90. http://dx.doi.org/10.1300/j006v06n03_03.

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38

Leetsma, J. E., and Amy Martin. "Forensic Neuropathology." Therapeutic Drug Monitoring 11, no. 1 (1989): 115. http://dx.doi.org/10.1097/00007691-198901000-00027.

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39

Fenichel, Gerald. "Developmental Neuropathology." Cognitive and Behavioral Neurology 19, no. 2 (2006): 117. http://dx.doi.org/10.1097/01.wnn.0000213904.67450.8e.

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40

Palmer, Cheryl Ann. "NEUROPATHOLOGY REVIEW." Neuro-Oncology 4, no. 1 (2002): 49–50. http://dx.doi.org/10.1093/neuonc/4.1.49.

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41

Lantos, P. "Greenfield's Neuropathology." Journal of Neurology, Neurosurgery & Psychiatry 48, no. 5 (1985): 496. http://dx.doi.org/10.1136/jnnp.48.5.496.

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42

Jellinger, K. A. "Neuropathology Techniques." European Journal of Neurology 11, no. 10 (2004): 719. http://dx.doi.org/10.1111/j.1468-1331.2004.00834.x.

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43

Jellinger, K. A. "Developmental Neuropathology." European Journal of Neurology 12, no. 8 (2005): 663. http://dx.doi.org/10.1111/j.1468-1331.2005.01040.x.

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44

Jellinger, K. A. "Forensic Neuropathology." European Journal of Neurology 16, no. 2 (2009): e23-e23. http://dx.doi.org/10.1111/j.1468-1331.2008.02438.x.

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45

Jellinger, K. A., and C. Bancher. "AD neuropathology." Neurology 46, no. 4 (1996): 1186. http://dx.doi.org/10.1212/wnl.46.4.1186-b.

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46

Leech, R. W. "Pediatric Neuropathology." Neurology 48, no. 3 (1997): 793–94. http://dx.doi.org/10.1212/wnl.48.3.793-b.

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47

Wharton, S. B. "Neuropathology Techniques." Histopathology 45, no. 6 (2004): 641. http://dx.doi.org/10.1111/j.1365-2559.2004.01965.x.

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48

Reichard, R. Ross. "Autopsy Neuropathology." Academic Forensic Pathology 2, no. 1 (2012): x—xi. http://dx.doi.org/10.1177/192536211200200103.

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49

Hart, Michael. "Greenfield's Neuropathology." Journal of Neuropathology & Experimental Neurology 67, no. 8 (2008): 828.1–828. http://dx.doi.org/10.1097/nen.0b013e3181839bfd.

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50

Burger, Peter C. "Diagnostic Neuropathology." American Journal of Clinical Pathology 92, no. 3 (1989): 393–94. http://dx.doi.org/10.1093/ajcp/92.3.393a.

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