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Paladichuk, A. "Chronic disease management: an outpatient approach". Critical Care Nurse 17, n.º 6 (30 de dezembro de 1997): 90–95. http://dx.doi.org/10.4037/ccn1997.17.6.90.
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The current climate of managed care has sparked efforts to reduce costs in patient care. In many cases, this has resulted in more efficient methods of patient management: chronic disease management in an outpatient setting appears to be one such success story. For critical care nurses interested in working beyond the boundaries of a traditional ICU, chronic disease management clinics represent an alternative environment in which they may apply their skills. Nancy Brass-Mynderse, RN, MSN, CCRN, a clinical nurse specialist (CNS) with 18 years of experience in critical care, was instrumental in development of the Scripps Health Chronic Disease Clinic at Green Hospital of Scripps Clinic, San Diego, Calif. Brass-Mynderse currently supervises the operation of the clinic, along with Omana Kaliangara, RN, MSN, CFNP, a nurse practitioner. Brass-Mynderse received her bachelor's degree from the University of Arizona, Tucson, Ariz, and her master's degree from San Diego State University. She recently obtained her family nurse practitioner certificate from California State University, Dominguez Hills, Calif. Kaliangara received her bachelor's degree from San Jose State University, San Jose, Calif, and her nurse practitioner certificate from the University of California, San Francisco, Calif. After working in family medicine and a diabetic clinic, Kaliangara developed an interest in the management of chronic diseases. In an interview with CRITICAL CARE NURSE in September, Brass-Mynderse and Kaliangara took time to discuss the development and operation of the clinic, and to recount some of their success stories.
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Ehlers, V. J. "Visit to the National University, San Diego, USA: 30 July 1999". Health SA Gesondheid 5, n.º 1 (23 de outubro de 2000): 64–66. http://dx.doi.org/10.4102/hsag.v5i1.23.
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The National University was founded in 1971 as an independent, non-profit institution of higher learning, focusing on the unique needs of midcareer adult learners, who are not seeking traditional residential university programmes. According to its information brochure, the National University is the third largest private university in California. More than 60 000 students had completed their studies in the arts and sciences, business, education, human services, nursing and technology at the beginning of 1999.
*Please note: This is a reduced version of the abstract. Please refer to PDF for full text.
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Watry, Paul. "Digital Preservation Theory and Application: Transcontinental Persistent Archives Testbed Activity". International Journal of Digital Curation 2, n.º 2 (2 de dezembro de 2008): 41–68. http://dx.doi.org/10.2218/ijdc.v2i2.28.
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The National Archives and Records Administration (NARA) and EU SHAMAN projects are working with multiple research institutions on tools and technologies that will supply a comprehensive, systematic, and dynamic means for preserving virtually any type of electronic record, free from dependence on any specific hardware or software. This paper describes the joint development work between the University of Liverpool and the San Diego Supercomputer Center (SDSC) at the University of California, San Diego on the NARA and SHAMAN prototypes. The aim is to provide technologies in support of the required generic data management infrastructure. We describe a Theory of Preservation that quantifies how communication can be accomplished when future technologies are different from those available at present. This includes not only different hardware and software, but also different standards for encoding information. We describe the concept of a “digital ontology” to characterize preservation processes; this is an advance on the current OAIS Reference Model of providing representation information about records. To realize a comprehensive Theory of Preservation, we describe the ongoing integration of distributed shared collection management technologies, digital library browsing, and presentation technologies for the NARA and SHAMAN Persistent Archive Testbeds.
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Beckman, Peter H. "Building the TeraGrid". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 363, n.º 1833 (18 de julho de 2005): 1715–28. http://dx.doi.org/10.1098/rsta.2005.1602.
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On 1 October 2004, the most ambitious high-performance Grid project in the United States—the TeraGrid—became fully operational. Resources at nine sites—the San Diego Supercomputer Center, the California Institute of Technology, the National Center for Supercomputing Applications, the University of Chicago/Argonne National Laboratory, Pittsburgh Supercomputing Center, Texas Advanced Computing Center, Purdue University, Indiana University and Oak Ridge National Laboratory—were joined via an ultra-fast optical network, unified policies and security procedures and a sophisticated distributed computing software environment. Funded by the National Science Foundation, the TeraGrid enables scientists and engineers to combine distributed, multiple data sources with computation at any of the sites or link massively parallel computer simulations to extreme-resolution visualizations at remote sites. A single shared utility lets multiple resources be easily leveraged and provides improved access to advanced computational capabilities. One of the demonstrations of this new model for using distributed resources, Teragyroid, linked the infrastructure of the TeraGrid with computing resources in the United Kingdom via a transatlantic data fibre link. Once connected, the software framework of the RealityGrid project was used to successfully explore lattice-Boltzmann simulations involving lattices of over one billion sites.
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Minor, David, Don Sutton, Ardys Kozbial, Brad Westbrook, Michael Burek e Michael Smorul. "Chronopolis Digital Preservation Network". International Journal of Digital Curation 5, n.º 1 (22 de junho de 2010): 119–33. http://dx.doi.org/10.2218/ijdc.v5i1.147.
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The Chronopolis Digital Preservation Initiative, one of the Library of Congress’ latest efforts to collect and preserve at-risk digital information, has completed its first year of service as a multi-member partnership to meet the archival needs of a wide range of domains.Chronopolis is a digital preservation data grid framework developed by the San Diego Supercomputer Center (SDSC) at UC San Diego, the UC San Diego Libraries (UCSDL), and their partners at the National Center for Atmospheric Research (NCAR) in Colorado and the University of Maryland's Institute for Advanced Computer Studies (UMIACS).Chronopolis addresses a critical problem by providing a comprehensive model for the cyberinfrastructure of collection management, in which preserved intellectual capital is easily accessible, and research results, education material, and new knowledge can be incorporated smoothly over the long term. Integrating digital library, data grid, and persistent archive technologies, Chronopolis has created trusted environments that span academic institutions and research projects, with the goal of long-term digital preservation.A key goal of the Chronopolis project is to provide cross-domain collection sharing for long-term preservation. Using existing high-speed educational and research networks and mass-scale storage infrastructure investments, the partnership is leveraging the data storage capabilities at SDSC, NCAR, and UMIACS to provide a preservation data grid that emphasizes heterogeneous and highly redundant data storage systems.In this paper we will explore the major themes within Chronopolis, including:a) The philosophy and theory behind a nationally federated data grid for preservation. b) The core tools and technologies used in Chronopolis. c) The metadata schema that is being developed within Chronopolis for all of the data elements. d) Lessons learned from the first year of the project.e) Next steps in digital preservation using Chronopolis: how we plan to strengthen and broaden our network with enhanced services and new customers.
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Georgakakos, Konstantine P. "US corporate technology transfer in hydrometeorology". Journal of Hydroinformatics 4, n.º 1 (1 de janeiro de 2002): 3–13. http://dx.doi.org/10.2166/hydro.2002.0002.
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Corporate technology transfer by US non-governmental organizations with the substantial involvement of university faculty is a new activity in hydrometeorology. The issues involved in such US corporate technology transfers are discussed by way of two examples selected from the activities of the Hydrologic Research Center, a non-profit-making public-benefit research and technology transfer corporation in San Diego, California, USA. The projects discussed are: (a) the development and implementation of a robust state estimator for national use within the US National Weather Service River Forecast System, and (b) the development and implementation of a prototype multi-sensor rainfall forecasting system for the Panama Canal Authority. The issues covered include technical ones associated with improving theoretical formulations for robust operational performance, those associated with the necessary reciprocal education between modellers and field personnel, and the accommodation of the educational objectives of participating postdoctoral associates.
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Blashill, Aaron J., Janna R. Gordon, Sarah A. Rojas, Christian B. Ramers, Chii-Dean Lin, Claudia M. Carrizosa, Kelsey A. Nogg et al. "Pilot randomised controlled trial of a patient navigation intervention to enhance engagement in the PrEP continuum among young Latino MSM: a protocol paper". BMJ Open 11, n.º 5 (maio de 2021): e040955. http://dx.doi.org/10.1136/bmjopen-2020-040955.
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IntroductionMen who have sex with men (MSM) are one of the most at-risk group for contracting HIV in the USA. However, the HIV epidemic impacts some groups of MSM disproportionately. Latino MSM comprise 25.1% of new HIV infections among MSM between the ages of 13 and 29 years. The daily medication tenofovir/emtricitabine was approved by the Food and Drug Administration for pre-exposure prophylaxis (PrEP) in 2012 and has demonstrated strong efficacy in reducing HIV acquisition.Methods and analysisThrough extensive formative research, this study uses a pilot randomised controlled trial design and will examine the feasibility and acceptability of a patient navigation intervention designed to address multiple barriers to improve engagement in the PrEP continuum among 60 Latino MSM between the ages of 18 and 29 years. The patient navigation intervention will be compared with usual care plus written information to evaluate the feasibility and acceptability of the intervention and study methods and the intervention’s potential in improving PrEP continuum behaviours. The results will be reviewed for preparation for a future full-scale efficacy trial.Ethics and disseminationThis study was approved by the institutional review board at San Diego State University and is registered at ClinicalTrials.gov. The intervention development process, plan and the results of this study will be shared through peer-reviewed journal publications, conference presentations and healthcare system and community presentations.Registration detailsRegistered under the National Institutes of Health’s ClinicalTrials.gov (NCT04048382) on 7 August 2019 and approved by the San Diego State University (HS-2017–0187) institutional review board. This study began on 5 August 2019 and is estimated to continue through 31 March 2021. The clinical trial is in the pre-results stage.
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Salimi, Rana. "The Female Bomber's Body in Performance". New Theatre Quarterly 30, n.º 1 (fevereiro de 2014): 51–64. http://dx.doi.org/10.1017/s0266464x14000074.
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Following the rules of self-sacrifice for a higher cause, the Palestinian female bomber performs the values of the struggle through and on her body in a farewell video statement. She leaves herself behind to create an image of a strong and victorious soldier. The female bomber's performance of the new self introduces her as a role model for younger generations. Her public appearance in hijab challenges notions of the body, physical beauty, and freedom in the secularist world at the same time as it deviates from the norms of a fundamentalist view of women. It is the dual impact on local and international viewers that politicizes the female bomber's public performance and makes it significant. Rana Salimi has received her PhD from the Department of Theatre and Dance at the University of California, San Diego. She currently lectures at UCSD and at National University on a variety of subjects, including theatre history and language arts.
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Farid, Marjan. "Pearls for Secondary Intraocular Lens Implantation". US Ophthalmic Review 10, n.º 01 (2017): 13. http://dx.doi.org/10.17925/usor.2017.10.01.13.
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Marjan Farid is Director of the Cornea, Cataract, and Refractive Surgery Faculty and Vice-chair of the Ophthalmic Faculty at the Gavin Herbert Eye Institute (GHEI) at the University of California, Irvine (UCI), California, US. Dr Farid’s clinical practice is divided between patient care, teaching, and research. She enjoys teaching ophthalmology to medical students, ophthalmology residents, and cornea fellows. She serves on the Residency Education Committee and is the Director of the cornea fellowship program at the GHEI. Her research interests focus on corneal surgery, specifically in the use of the femtosecond laser for corneal transplantation. She performs all forms of corneal transplantation—femtosecond enabled and lamellar keratoplasty (DSEK and DALK). Dr Farid is also the founder of the severe ocular surface disease center at UCI. She performs limbal stem cell transplants, as well as artificial corneal transplantation for the treatment of patients with severe ocular surface disorders. She serves as an associate medical director for the Sight Life Eye Bank. Her work has been published in numerous peer-reviewed journals, she has authored six textbook chapters, and travels to multiple national meetings to present her research work. She serves as an Editorial Board member of Ophthalmology, the leading journal in her field. Dr Farid graduated summa cum laude from UCLA with a degree in biology. She earned her medical degree at UC-San Diego in 2002 and completed a transitional year internship at Scripps-Mercy Hospital in San Diego. She completed her residency training in ophthalmology at UCI. She subsequently completed her fellowship training in the area of cornea/external disease and refractive surgery under the mentorship of Dr Roger Steinert at UCI.
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kirkpatrick, susan. "E Pluribus Unum?" PMLA/Publications of the Modern Language Association of America 117, n.º 5 (outubro de 2002): 1279–83. http://dx.doi.org/10.1632/003081202x61188.
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Forty years ago, when my department was established as one of the first departments of the new San Diego campus of the University of California (UCSD), its founders had a free hand to construct a new model for literary study by recasting the institutional infrastructure that traditionally divided the field by language or language group. The initial vision, as summarized in the introduction to an early graduate program review, was relatively abstract:The Department of Literature was founded […] on the uncommon but quite logical assumption that there are habits of mind and methods of inquiry peculiar to literary study, whatever the language, and that the literatures of the world have more in common than the usual departmental divisions acknowledge. […] From the standpoint of research and teaching interests, [its structure] runs counter to the provincialism that afflicts many departments of single national literatures.(“Graduate Program Review”)
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Cardenas, Veronica, Yuko Abbott, Jeremy M. Hirst, Brent T. Mausbach, Suzanne Agarwal, Georgianna Collier, Luke Tran et al. "Development, implementation, and initial results of the UC San Diego Health Moores Cancer Center Wellbeing Screening Tool". Palliative and Supportive Care 17, n.º 04 (2 de janeiro de 2019): 431–35. http://dx.doi.org/10.1017/s1478951518000810.
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AbstractObjectiveAll accredited cancer institutions are required to screen patients for psychosocial distress. This paper describes the development, implementation, and preliminary outcomes of the University of California San Diego Health Moores Cancer Center Wellbeing Screening Program.MethodEssential steps learned in a formal National Cancer Institute–funded training workshop entitled “Implementing Comprehensive Biopsychosocial Screening” were followed to ensure successful program implementation. These steps included identification of stakeholders; formation of a working committee; establishment of a vision, process, and implementation timeline; creation of a screening tool; development of patient educational material; tool integration into an electronic medical record system; staff training and pilot testing of tool administration; and education about tool results and appropriate follow-up actions. Screening data were collected and analyzed retrospectively for preliminary results and rapid cycle improvement of the wellbeing screening process.ResultsOver an 8-month implementation and assessment period, the screening tool was administered 5,610 times of 7,664 expected administrations (73.2%.) to 2,394 unique patients. Visits in which the questionnaire was administered averaged 39.6 ± 14.8 minutes, compared with 40.3 ± 15.2 minutes for visits in which the questionnaire was not administered (t = −1.76, df = 7,662, p = 0.079).Significance of resultsThis program provides a process and a tool for successful implementation of distress screening in cancer centers, in a meaningful way for patients and providers, while meeting accreditation standards. Further, meaningful data about patient distress and tool performance were able to be collected and utilized.
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Niederberger, Erin, Sarah A. Buchanan e Hali Allen. "Mary F. Lenox: Library and Information Science Connector and Poet of Justice". Libraries: Culture, History, and Society 6, n.º 1 (1 de março de 2022): 187–210. http://dx.doi.org/10.5325/libraries.6.1.0187.
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ABSTRACT Mary F. Lenox, born 1944, is a notable scholar, library school leader, Kellogg National Fellow 1982, school librarian in Chicago (MLS Rosary College), and ardent poet. Best known as the first Black dean at the University of Missouri, Dr. Lenox has many accomplishments before, within, and after that post meriting parallel recognition. She is a role model for Black students and faculty across the campus, and for her compeers nationwide – colleagues in ALA’s then-Young Adult Services Division and readers of her poetry in two books (2015, 2019), spoken at TEDx San Diego, or on the airwaves anew after the killing of George Floyd in May 2020. In our study of Dr. Lenox’s LIS educator career we draw together her leadership of the school librarianship study program and grants, her successful organizing against proposed budget cuts and selection as dean, and her scholarship on libraries in African American life, youth services, and cooperative multimedia-collection building.
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Johnson, Patricia. "Reviewer Acknowledgements for Studies in Media and Communication, Vol. 10, No. 2". Studies in Media and Communication 10, n.º 2 (28 de novembro de 2022): 356. http://dx.doi.org/10.11114/smc.v10i2.5804.
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Studies in Media and Communication (SMC) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether SMC publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 10, Number 2Aina Fernàndez Aragonès, Tecnocampus-UPF, SpainAmie Jones, University of Georgia, USAAndreas Veglis, Aristotle University of Thessaloniki, GreeceAyşe Aslı Sezgin, Çukurova University, TurkeyBernard Naledzani Rasila, University of Venda, South AfricaCaitlin McLaughlin, St. Francis Xavier University, CanadaCamelia Cmeciu, Danubius University of Galati, RomaniaCarmen Pérez-Sabater, Universitat Politècnica de València, SpainChristof Demont-Heinrich, University of Denver, USAFrancis Adyanga Akena, Kabale University Uganda, UgandaHerman, Universitas HKBP Nommensen Pematangsiantar, IndonesiaImed Ben Labidi, Doha Institute for Graduate Studies, USAIrina Milutinović, Institute of European Studies, Belgrade, SerbiaJianbo Hou, Xi'an International Studies University, ChinaLambrini Papadopoulou, National and Kapodistrian University, GreeceMaría José Serrano, Universidad de La Laguna, SpainMasduki Masduki, Universitas Islam Indonesia, IndonesiaMatthias Degen, Westphalian University of Applied Sciences, GermanyMunira Fayzulloeva, Tajik State University of Law, TajikistanNavid Darvishzadeh, Georgia State University, USANina Gunnarsson, Jönköping university, SwedenNingyang Chen, Soochow University, ChinaPeggy Peattie, University of San Diego, USAPhilemon Bantimaroudis University of Cyprus, CyprusRefat Aljumily, Newcastle University, UKSixto-García José, University of Santiago de Compostela, SpainTilahun Adamu Mengistie, University of Gondar, EthiopiaVerlumun Celestine Gever, University of Nigeria, NigeriaXiao Li, Hubei Institute of Fine Arts, ChinaYoung Joon Lim, University of Texas Rio Grande Valley, USAPatricia JohnsonEditorial AssistantOn behalf of,The Editorial Board of Studies in Media and CommunicationRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://smc.redfame.com
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Kohlmaier, Gundolf Hans. "The use of wood for construction and energy in the natural city: The case of Canada". Ekistics and The New Habitat 71, n.º 424-426 (1 de junho de 2004): 102–12. http://dx.doi.org/10.53910/26531313-e200471424-426234.
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The author received a Ph. D in physical chemistry from the University of Washington, Seattle, USA in 1962. At present he is Professor for Physical and Theoretical Chemistry at the Division Geo Sciences and Geography, Institute for the Atmosphere and the Environment, Goethe University of Frankfurt, Germany. His work ranges from the quantum mechanical description of molecules to the dynamics of global systems. In 1973 he introduced the first interdisciplinary course on "chemistry and environment; an ecological approach to chemical processes in nature and technology" at the University of Frankfurt. Later his emphasis focused on biogeochemical cycles, in particular, the "global carbon cycle, biosphere and climate." In cooperation with his co-workers he developed a world model for the CO2 exchange between the biosphere and the atmosphere, the "Frankfurt Biosphere Model, FBM." He was visiting professor at the University of California, Berkeley, as well as Los Angeles and San Diego (Scripps Institution of Oceanography), University of Louvain-la-Neuve, Belgium, Tropical Science Center of Costa Rica, University of Paris, Orsay, the National Australian University, Canberra, and most recently Stanford University, USA. He was director of the Institute for Physical and Theoretical Chemistry and of the former Center for Environmental Studies (Zentrum für Umweltforschung ZUF) of the University of Frankfurt. In 1991 he was awarded the Philip Morris Research Prize "Challenge Future" for his work on the carbon cycle connected with the development of the Frankfurt Biosphere Model. In 1998, following a workshop in Freising, Germany, he, together with his colleagues M. Weber and R.A. Houghton, published the Springer Book: Carbon Dioxide Mitigation in Forestry and Wood Industry. Professor Kohlmaier became a member of the World Society of Ekistics in 2001, returning to his roots as his father was an architect.
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Gonzalez, Kevin, Wassim Tarraf, Ariana Stickel, Sonya Kaur, Christian Agudelo, Jianwen Cai, Linda Gallo et al. "0324 sleep duration and brain MRI biomarkers: results from SOL-INCA MRI study". Sleep 45, Supplement_1 (25 de maio de 2022): A146. http://dx.doi.org/10.1093/sleep/zsac079.322.
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Abstract Introduction Long and short sleep have been associated with stroke and dementia. Sleep patterns may differ by sex and Hispanic/Latino background. Within Hispanics/Latinos heterogeneity in sleep outcomes exists and is understudied. The purpose of this study was to examine associations between sleep duration and MRI biomarkers of brain health. Methods SOL-Investigation of Neurocognitive Aging (SOL-INCA) MRI study is an ongoing ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Our analytic sample consisted of 1,103 adults 50-years and older from diverse Hispanics/Latino backgrounds that completed baseline sleep assessments (2008-2011) and underwent neuroimaging (2018-ongoing; Mean age 64 ±6.9 years). The main exposures were baseline self-reported average nightly sleep duration. Outcomes included brain volume measures residualized for cranial volume (e.g. total brain, hippocampal, and white matter hyperintensities). Brain outcomes were modeled, using regression techniques, as a function of sleep duration and adjusting for age, sex, education, Hispanic/Latino background, language use, self-reported cardiovascular events, BMI, depressive symptoms, Apena/Hypopena index and self-reported sleep quality. Results Mean sleep duration was 7.7 ± 1.36 hours, and 13.2% reported sleeping >9 hours. Increasing sleep duration was associated with smaller total brain (Btotal_brain -1.32 [-2.33 ; -0.32], p<0.05) per hour increment and larger lateral ventricle volumes (Blateral_ventricle=0.02 [~0.00; 0.04], p<0.05) after adjusting for sociodemographic, behavioral, cardio-vascular and sleep quality characteristics. The associations were not modified by sex or Hispanic/Latino background. Conclusion We found that increments in sleep duration was associated with lower total brain volume and larger ventricle size, MRI measures that could associate with increased dementia-risk in diverse Hispanic/Latino adults. Support (If Any) This work is supported by National Institute on Aging (R01AG048642, RF1AG054548, and R01AG063868) and by the National Heart Lung Blood Institute (R01HL098297). Dr. González also receives additional support from P30AG59299. The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-philip glass beck HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution-Office of Dietary Supplements.
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Schneider, Jerry, e Elena Levtchenko. "A Personal History of Cystinosis by Dr. Jerry Schneider". Cells 11, n.º 6 (10 de março de 2022): 945. http://dx.doi.org/10.3390/cells11060945.
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Cystinosis is a rare lysosomal storage disease that is tightly linked with the name of the American physician and scientist Dr. Jerry Schneider. Dr. Schneider (1937–2021) received his medical degree from Northwestern University, followed by a pediatrics residency at Johns Hopkins University and a fellowship in inherited disorders of metabolism. He started to work on cystinosis in J. Seegmiller’s laboratory at the National Institutes of Health (NIH) and subsequently moved to the UC San Diego School of Medicine, where he devoted his entire career to people suffering from this devastating lysosomal storage disorder. In 1967, Dr. Schneider’s seminal Science paper ‘Increased cystine in leukocytes from individuals homozygous and heterozygous for cystinosis’ opened a new era of research towards understanding the pathogenesis and finding treatments for cystinosis patients. His tremendous contribution transformed cystinosis from a fatal disorder of childhood to a treatable chronic disease, with a new generation of cystinosis patients being now in their 40th and 50th years. Dr. Schneider wrote a fascinating ‘Personal History of Cystinosis’ highlighting the major milestones of cystinosis research. Unfortunately, he passed away before this manuscript could be published. Fifty-five years after his first paper on cystinosis, the ‘Personal History of Cystinosis’ by Dr. Schneider is a tribute to his pioneering discoveries in the field and an inspiration for young doctors and scientists who have taken over the torch of cystinosis research towards finding a cure for cystinosis.
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Pittman, Scott. "Lifting the Veil". California History 91, n.º 4 (2014): 43–55. http://dx.doi.org/10.1525/ch.2014.91.4.43.
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The story of anti-communism in California schools is a tale well and often told. But few scholars have appreciated the important role played by private surveillance networks. This article examines how privately funded and run investigations shaped the state government’s pursuit of leftist educators. The previously-secret papers of Major General Ralph H. Van Deman, which were opened to researchers at the National Archives in Washington, D.C., only a few years ago, show that the general operated a private spy network out of San Diego and fed information to military, federal, and state government agencies. Moreover, he taught the state government’s chief anti-communist bureaucrat, Richard E. Combs, how to recruit informants and monitor and control subversives. The case of the suspicious death of one University of California, Los Angeles student – a student that the anti-communists claimed had been “scared to death” by the Reds – shows the extent of the collaboration between Combs and Van Deman. It further illustrates how they conspired to promote fear of communism, influence hiring and firing of University of California faculty, and punish those educators who did not support their project. Although it was rarely successful, Combs’ and Van Deman’s coordinated campaign reveals a story of public-private anticommunist collaboration in California that has been largely forgotten. Because Van Deman’s files are now finally open to researchers, Californians can gain a much more complete understanding of their state bureaucracy’s role in the Red Scare purges of California educators.
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Manger, Walter L. "Examining the Creation-Evolution Issue as a Humanities Course". Paleontological Society Papers 5 (outubro de 1999): 235–42. http://dx.doi.org/10.1017/s1089332600000644.
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In early 1981, the 73rd General Assembly of the State of Arkansas in regular session passed Senate Bill 482 without debate. Governor Frank White, immediately signed the bill, admitting that he hadn't read it, and it became state law as Act 590, the “Balanced Treatment for Creation-Science and Evolution-Science Act.” A suit on behalf of 23 plaintiffs was filed by the American Civil Liberties Union (ACLU) on May 27, 1981, and a trial before Federal Judge William Overton was scheduled for October and then postponed until December, 1981. The trial began on December 7, 1981, and it received national attention. The ACLU called well-known expert witnesses in both religion (Bruce Vawter, George Marsden, and Langdon Gilkey) and science (Francisco Ayala, G. Brent Dalrymple, Stephen Jay Gould, and Carl Sagan). The state's witnesses were creationists associated with the Geoscience Research Institute, Loma Linda University, California (Harold Coffin, Ariel Roth), and the Creation Research Society, Ann Arbor, Michigan (Wayne Friar, Margaret Helder, Donald Chittick, Robert Gentry). Its “star” witness, at least in the eyes of the press, was Chandra Wickramasinghe, University College of Wales. The trial did not involve any of the high profile creationists, such as Henry Morris or Duane Gish, from the Institute for Creation Research (ICR) in San Diego, even though it was disclosed that Wendall R. Bird, an attorney associated with (ICR), had written the act. Both sides called local educators. Judge Overton issued his ruling and an injunction permanently prohibiting enforcement of Act 590 on January 5, 1982. The state did not appeal his ruling.
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Johnson, Patricia. "Reviewer Acknowledgements for Studies in Media and Communication, Vol. 11, No. 7". Studies in Media and Communication 11, n.º 7 (28 de novembro de 2023): 415. http://dx.doi.org/10.11114/smc.v11i7.6562.
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Studies in Media and Communication (SMC) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether SMC publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 11, Number 7Abel Suing, Universidad Técnica Particular de Loja, EcuadorAina Fernàndez Aragonès, Tecnocampus-UPF, SpainAmie Jones, University of Georgia, USAAndré Iribure Rodrigues, Universidade Federal do Rio Grande do Sul, BrazilAnita Šulentić, Edward Bernays University College, CroatiaAntonio García Gómez, University of Alcalá de Henares, SpainAref Abu-Gweder, Achva Acadmic, IsraelAyşe Aslı Sezgin, Çukurova University, TurkeyBarira Bakhtawar, Information Technology University of the Punjab, PakistanBernard Naledzani Rasila, University of Venda, South AfricaBranco Di Fátima, University of Beira Interior (UBI), PortugalDaniel Moise, Bucharest University, RomaniaDonggyu Kim, University of Southern California, USADonka Petrova, Sofia University “St. Kliment Ohridski”, BulgariaElsir Ali Saad Mohamed, Umm Al Quwain University, UAEFarhina Hameed, National University of Modern Languages, PakistanFilosa Gita Sukmono, Universitas Muhammadiyah Yogyakarta, IndonesiaFrans Sayogie, Universitas Islam Negeri Syarif Hidayatullah Jakarta, IndonesiaFred Fang, South China Normal University, ChinaGebru Kahsay Kiflu, Adigrat University, EthiopiaGiorgio Poletti, University of Ferrara, ItalyGopolang Ditlhokwa, University of Botswana, BotswanaGordana Lesinger, Josip Juraj Strossmayer University in Osijek, CroatiaGuanqin He, Utrecht University, JordanHerman, Universitas HKBP Nommensen Pematangsiantar, IndonesiaHsu Thiri Zaw, National Management Degree College, MyanmarImed Ben Labidi, Doha Institute for Graduate Studies, USAJarlene Rodrigues Reis, Cefet/RJ, BrazilJiagui Li, Macao Polytechnic University, MacaoJianbo Hou, Xi'an International Studies University, ChinaJosé Sixto-García, University of Santiago de Compostela, SpainKarim Ben Yahia, University of Bahrain, BahrainKhaled Al-Kassimi, American University in the Emirates, UAEKun Yu, Universiti Putra Malaysia, ChinaLidia Peralta García, University of Granada, SpainLucia Zbihlejová, University of Presov, SlovakiaMalavika Anakkathil Anil, Western Sydney University, AustraliaMargaréta Nadányiová, AMBIS University, SlovakMaría Guadalupe Venteño, National Autonomous University of Mexico, MexicoMarta Rizo García, Universidad Autónoma de la Ciudad de México, MexicoMaryna Grynyshyna, Kyiv National University of Culture and Arts, UkraineMasduki Masduki, Universitas Islam Indonesia, IndonesiaMatthias Degen, Westphalian University of Applied Sciences, GermanyMiguel Álvarez-Peralta, University Rey Juan Carlos, SpainMohammad Zamroni, Sunan Kalijaga State Islamic University, IndonesiaMunira Fayzulloeva, Tajik State University of Law, TajikistanNavid Darvishzadeh, Georgia State University, USANina Gunnarsson, Jönköping university, SwedenNingyang Chen, Soochow University, ChinaPatrick Neil M. Santiago, Nueva Ecija University of Science and Technology, PhilippinesPeggy Peattie, University of San Diego, USAPhilemon Bantimaroudis, University of Cyprus, CyprusRafael Ángel Rodríguez López, University of Malaga, SpainRafael Angel Salazar Martínez, University of Holguin-Mayari Municipality Center, CubaRafiza Luziani Varão Ribeiro Carvalho, University of Brasilia, BrazilRamez Abuhasirah, Middle East University, JordanRaúl Rojas-Andrés, Universidad de Castilla-La Mancha (UCLM), SpainSarah Min, Dalton State College, USASevda Ünal, Çukurova University, TurkeySeverin Mbog, University of Douala, CameroonStefan Markov, Sofia University, BulgariaTeresa Martín García, University of Salamanca, SpainVeneza Mayora Ronsini, Federal University of Santa Maria, BrazilVerlumun Celestine Gever, University of Nigeria, NigeriaVladimir Dosev, University of Economics - Varna, BulgariaXiao Li, Hubei Institute of Fine Arts, ChinaYoung Joon Lim, University of Texas Rio Grande Valley, USAYudie Aprianto, Universitas Gadjah Mada, IndonesiaYuyun Wahyu Izzati Surya, Airlangga University, IndonesiaZeinab Abulhul, George Mason University, USAZeynep Genel, İstanbul Okan University, TurkeyPatricia JohnsonEditorial AssistantOn behalf of,The Editorial Board of Studies in Media and CommunicationRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://smc.redfame.com
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Nayak, Rikin J., e Jitendra P. Chaudhari. "Anomaly detection using deep learning based model with feature attention". IAES International Journal of Artificial Intelligence (IJ-AI) 13, n.º 1 (1 de março de 2024): 383. http://dx.doi.org/10.11591/ijai.v13.i1.pp383-390.
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<span lang="EN-US">Anomaly detection is a difficult problem with numerous industrial applications, such as analyzing the quality of objects using images. Anomaly detection is the process of identifying outliers in a given dataset. Recently, machine learning approaches to computer vision problems have outperformed classical state-of-the-art approaches. Anomaly detection problems can be solved using supervised approaches. However, labelled datasets are hard to obtain. Thus, many researchers have taken an unsupervised approach to solving the problem of anomaly detection. In this study, we use an adversarial auto encoder model as a base model and create a custom model to detect anomalies in images and videos. The model was trained exclusively on normal data. The modified national institute of standards and technology database (MNIST) dataset achieved an area under curve (AUC) score of 0.872 for anomaly detection, while the University of California San Diego (UCSD) anomaly dataset (Video dataset) achieved an AUC score of 0.74 for Ped1 and 0.87 for Ped2. To calculate the anomaly score, the concept of attention weights is combined with the reconstruction loss, and the proposed method outperformed other similar methods designed for the same problem. However, the usefulness of the proposed model was demonstrated through the detection of anomalies, and the model is still being improved for use in real-world situations.</span>
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Bazzo, David E. J., Patricia Smith e Elizabeth F. Wenghofer. "A Pilot Study of a Screening Process for Evaluating the Physical, Mental and Cognitive Health of Senior Physicians". Journal of Medical Regulation 107, n.º 2 (1 de julho de 2021): 33–40. http://dx.doi.org/10.30770/2572-1852-107.2.33.
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ABSTRACT Physicians are not immune to changes that accompany aging, including decreases in physical and cognitive health and abilities. Many are calling for, or turning to, screening senior physicians for decrements in their ability to provide safe care. Our purpose was to determine the acceptability and feasibility of a pilot screening process, which evaluates the physical, mental and cognitive health of senior physicians. The screening process was developed by the University of California, San Diego, Physician Assessment and Clinical Education Program. The screen included: mental health screening (PHQ-9, GAD-7, and substance abuse screen), cognitive health screening (MicroCog™ and Montreal Cognitive Assessment [MoCA©]) and physical health screening (medical history review and physical examination). Qualitative semi-structured interviews were conducted post-screening. Thirty senior physicians participated in the pilot process, including post-screening interviews. Eight (27%) participants were judged to “require”/“may require” further evaluation after cognitive assessment. No physicians were found to have physical or mental health issues that would prevent them from practicing competently. Interviews revealed that participants felt the screening process was a positive experience that was effective, acceptable, efficient and relevant to their practice. The results of this pilot study indicate that screening physical, mental and cognitive health is considered both feasible and acceptable to senior physicians. This is important as screening the health and cognition of senior physicians is integral to the national discussion related to regulation and patient safety.
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Maeda, Makiko, Douglas Humber, Eisuke Hida, Tomohito Ohtani, Guannan Wang, Tong Wu, Shiori Takeda et al. "Lower doses of carvedilol in Japanese heart failure patients with reduced ejection fraction could show the potential to be non-inferior to higher doses in US patients: An international collaborative observational study". PLOS ONE 19, n.º 3 (7 de março de 2024): e0299510. http://dx.doi.org/10.1371/journal.pone.0299510.
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The Japanese national guidelines recommend significantly lower doses of carvedilol for heart failure with reduced ejection fraction (HFrEF) management than the US guidelines. Using real-world data, we determined whether initial and target doses of carvedilol in Japanese patients (JPNs) differ from those in US patients (USPs), especially in Asian Americans (ASA) and Caucasians (CA), and investigated differences in outcomes. We collected data from the electronic medical records, including demographics, carvedilol dosing, tolerability, cardiac functional indicators like EF, cardiovascular events including all-cause deaths, and laboratory values from the University of California, San Diego Health and Osaka University. JPNs had significantly lower doses (mg/day) of carvedilol initiation (66 USPs composed of 38 CAs and 28 ASAs, 17.1±16.2; 93 JPNs, 4.3±4.2, p<0.001) and one year after initiation (33.0±21.8; 11.2±6.5, p<0.001), and a significantly lower relative rate (RR) of dose discontinuation and reduction than USPs (RR: 0.406, 95% confidence interval (CI): 0.181–0.911, p<0.05). CAs showed the highest reduction rate (0.184), and ASAs had the highest discontinuation rate (0.107). A slight mean difference with narrow 95% CI ranges straddling zero was observed between the two regions in the change from the baseline of each cardiac functional indicator (LVEF, -0.68 [−5.49–4.12]; LVDd, −0.55 [−3.24–2.15]; LVDd index, −0.25 [−1.92–1.43]; LVDs, −0.03 [−3.84–3.90]; LVDs index, −0.04 [−2.38–2.30]; heart rate, 1.62 [−3.07–6.32]). The event-free survival showed no difference (p = 0.172) among the races. Conclusively, despite JPNs exhibiting markedly lower carvedilol doses, their dose effectiveness has the potential to be non-inferior to that in USPs. Dose de-escalation, not discontinuation, could be an option in some Asian and ASA HFrEF patients intolerable to high doses of carvedilol.
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León, Rubén Hernández. "Wayne A. Cornelius, Ann L. Craig and Jonathan Fox (eds.), Transforming State–Society Relations in Mexico: The National Solidarity Strategy (La Jolla, CA: University of California, San Diego, 1994), pp. xiii + 368." Journal of Latin American Studies 27, n.º 1 (fevereiro de 1995): 249–50. http://dx.doi.org/10.1017/s0022216x00010452.
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Thompson, Sheri, e Lauren Pineda. "Mentorship Program Content Ratings: Advancing Diversity in Aging and Alzheimer’s Disease Research and Careers". Innovation in Aging 5, Supplement_1 (1 de dezembro de 2021): 974. http://dx.doi.org/10.1093/geroni/igab046.3507.
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Abstract MADURA is an R25 Advancing Diversity in Aging Research (ADAR) undergraduate training program funded by the National Institute on Aging and based at the University of California San Diego. Its objectives are to improve retention and academic success of underrepresented minority (URM) trainees, and to increase graduate/medical school applications and/or entry into Aging/ADRD careers. This multi-component program includes paid research lab experience, research and academic skills training, peer support, faculty-led small groups, guest seminars, and additional professional development opportunities. The Year 1 Cohort of 32 students consisted of Hispanic/Latinx and other students under-represented in collegiate MSTEM studies. Almost ¾ of the mentees also came from disadvantaged backgrounds, per current NIH criteria. Evaluation data have been collected through brief, weekly, anonymous online student surveys, plus more comprehensive quarterly mentee and mentor surveys. This poster will describe the Program structure and 20+ group activities, trainings, seminars, and modalities, and report student ratings of satisfaction and utility. 92% of trainees rated the overall program value as Excellent, and 92% also rated effectiveness in promoting Aging/ADRD careers among underrepresented students as Excellent. Quality ratings of components such as pay, research placements, group training and group mentorship were rated as Excellent or Good by 96%. Relative student component rankings, specific suggestions for improvements, plus Mentee and Mentor perspectives on research-specific training needs, will also be presented. Based upon these experiences and data, the authors will make specific suggestions for future URM research training, mentorship program content, and expanded delivery modalities.
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Kiselica, Andrew, e Kevin Duff. "Symposium 08: Neuropsychological Considerations for Alzheimer's Disease Clinical Trials". Journal of the International Neuropsychological Society 29, s1 (novembro de 2023): 504–5. http://dx.doi.org/10.1017/s1355617723006537.
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Summary Abstract:The 2011 National Institute on Aging and Alzheimer's Association (NIA-AA) criteria for the diagnosis of Alzheimer's disease (AD) focused on clinical signs and symptoms to make a diagnosis of probable or possible AD. Under these criteria, emphasis was placed on gathering objective evidence of cognitive decline, which gave neuropsychologists a central role as diagnosticians in AD clinical trials. The release of the 2018 NIA-AA research framework put greater emphasis on the use of biomarkers, especially measures of amyloid, tau, and neurodegeneration, to define AD. Once AD is defined based on these biomarkers, it is staged via clinical signs and symptoms. Thus, the role of neuropsychologists has shifted from being central to diagnosis to a possibly more ancillary role of staging the disease once it is determined to be present. The move away from clinical signs towards biomarkers only became more prominent with the recent, controversial Food and Drug Administration approval of Aducanumab as an AD treatment based on evidence of change in biomarkers without clear evidence of clinical benefit. In this landscape, the fit of neuropsychologists in AD clinical trial research has become less clear.This symposium will address the role of neuropsychologists in modern AD clinical trial research. The presenters will highlight varied ways in which neuropsychologists can enrich and improve AD clinical trials. First, Dr. Dustin Hammers from Indiana University will discuss how neuropsychological methods can help us to understand which participants do, and perhaps more importantly, do not get enrolled in clinical trials. Second, Dr. Mirella Diaz-Santos from the University of California Los Angeles will summarize her work to enroll Hispanic individuals in the Human Connectome Project, improving inclusivity. Third, Dr. Tamar Gollan from the University of California San Diego will summarize her work on novel behavioral markers of AD risk discovered from the study of Spanish-English bilingual patients. Fourth, Dr. Andrew Kiselica from the University of Missouri will highlight psychometric considerations in interpreting clinically meaningfully change in AD clinical trials using data from the National Alzheimer's Coordinating Center. Fifth, Dr. Samantha John from the University of Nevada at Las Vegas will discuss the influence of race/ethnicity on how clinically meaningful change is defined using data from a diverse cohort.Dr. Kevin Duff will serve as discussant for this series of studies. He will highlight the important roles that neuropsychologists can play in improving AD clinical trial screening processes, expanding inclusion of diverse patients into trials, and enhancing interpretation of the clinical meaningfulness of trial results. He will also reflect on the future of neuropsychology's role in the AD clinical trial landscape and encourage audience questions and responses to the research presented.
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Johnson, Patricia. "Reviewer Acknowledgements for Studies in Media and Communication, Vol. 12, No. 2". Studies in Media and Communication 12, n.º 2 (21 de janeiro de 2024): 396. http://dx.doi.org/10.11114/smc.v12i2.6928.
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Studies in Media and Communication (SMC) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether SMC publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 12 Number 2 Abel Suing, Universidad Técnica Particular de Loja, EcuadorAina Fernàndez Aragonès, TecnocampusUPF, SpainÁlvaro Jiménez Sánchez, University of Valladolid, SpainAndré Iribure Rodrigues, Universidade Federal do Rio Grande do Sul, BrazilAndreas Veglis, Aristotle University of Thessaloniki, GreeceAntonio García Gómez, University of Alcalá de Henares, SpainAyşe Aslı Sezgin, Çukurova University, TurkeyBernard Naledzani Rasila, University of Venda, South AfricaBranco Di Fátima, University of Beira Interior (UBI), PortugalCamelia Cmeciu, Danubius University of Galati, RomaniaCarlos Andrés Trejos-Gil, Universidad Católica Luis Amigó, ColombiaDaniel Moise, Bucharest University, RomaniaDario Nikić Čakar, University of Zagreb, CroatiaDi Zhang, Universiti Putra Malaysia, ChinaDonka Petrova, Sofia University “St. Kliment Ohridski”, BulgariaDorela Kaçauni, “Fan S. Noli” University, AlbaniaElsa Simões, Fernando Pessoa University, PortugalElsir Ali Saad Mohamed, Umm Al Quwain University, UAEErika Tiburcio Moreno, Carlos III University, SpainEva Solomon, University of Dar es Salaam, TanzaniaFerit Hysa, Dardania College, AlbaniaFilosa Gita Sukmono, Universitas Muhammadiyah Yogyakarta, IndonesiaFrans Sayogie, Universitas Islam Negeri Syarif Hidayatullah Jakarta, IndonesiaFred Fang, South China Normal University, ChinaGebru Kahsay Kiflu, Adigrat University, EthiopiaGopolang Ditlhokwa, University of Botswana, BotswanaGordana Lesinger, Josip Juraj Strossmayer University in Osijek, CroatiaHarisur Rahman, North South University, BangladeshHsu Thiri Zaw, National Management Degree College, MyanmarJarlene Rodrigues Reis, Cefet/RJ, BrazilJianbo Hou, Xi'an International Studies University, ChinaJosé SixtoGarcía, University of Santiago de Compostela, SpainJosipa Bubaš, Independent Researcher, CroatiaKarim Ben Yahia, University of Bahrain, BahrainKrešimir Žažar, University of Zagreb, CroatiaLei Ye, Hefei Normal University, ChinaLidia Peralta García, University of Granada, SpainLucia Zbihlejová, University of Presov, SlovakiaMaria de los Angeles Ferrer Mavarez, Universidad Tecnológica Metropolitana, ChileMaría Guadalupe Venteño, National Autonomous University of Mexico, MexicoMaría José Serrano, Universidad de La Laguna, SpainMarta Rizo García, Universidad Autónoma de la Ciudad de México, MexicoMartial Agbor Fanga, The University of Religions and Denominations, IranMasduki Masduki, Universitas Islam Indonesia, IndonesiaMatthias Degen, Westphalian University of Applied Sciences, GermanyMohammad Zamroni, Sunan Kalijaga State Islamic University, IndonesiaNavarro Nicoletti Felipe, CONICET-Universidad Nacional de Rio Negro, ArgentinaNgoc Tai Huynh, Tra Vinh University, VietnamNina Gunnarsson, Jönköping university, SwedenNingyang Chen, Soochow University, ChinaPatrick Neil M. Santiago, Nueva Ecija University of Science and Technology, PhilippinesPeggy Peattie, University of San Diego, USAPhilemon Bantimaroudis, University of Cyprus, CyprusRafael Ángel Rodríguez López, University of Malaga, SpainRafiza Luziani Varão Ribeiro Carvalho, University of Brasilia, BrazilRamez Abuhasirah, Middle East University, JordanRanda A. Makled, Beijing University of Technology, ChinaSarah Min, Dalton State College, USASeverin Mbog, University of Douala, CameroonStefan Markov, Sofia University, BulgariaVeneza Mayora Ronsini, Federal University of Rio Grande do Sul, BrazilVladimir Dosev, University of EconomicsVarna, BulgariaXiao Li, Hubei Institute of Fine Arts, ChinaYi Luo, Montclair State University, USAYoung Joon Lim, University of Texas Rio Grande Valley, USAYudie Aprianto, Universitas Gadjah Mada, IndonesiaYuhan Wang, Guangdong University of Technology, ChinaZeinab Abulhul, George Mason University, USAZeynep Genel, İstanbul Okan University, Turkey Patricia JohnsonEditorial AssistantOn behalf of,The Editorial Board of Studies in Media and CommunicationRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://smc.redfame.com
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Ramos, Alberto, Kevin Gonzalez, Wassim Tarraf, Susan Redline, Sanjay Patel, Ariana Stickel, Christian Agudelo et al. "0322 sleep disordered breathing and MRI makers of brain aging in the Hispanic Community Health Study/Study of Latinos". Sleep 45, Supplement_1 (25 de maio de 2022): A145. http://dx.doi.org/10.1093/sleep/zsac079.320.
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Abstract Introduction We aim to determine if white matter hyperintensities and decreased brain volumes are associated with sleep-disordered breathing (SDB), in a diverse sample of middle-aged and older Hispanic/Latino adults. Methods Our sample of 1,119 Hispanics/Latinos (ages older than 50-years; 70% female) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) underwent brain magnetic resonance imaging (MRI) as part of the Study of Latinos - Investigation of Neurocognitive Aging MRI (SOL-INCA MRI) ancillary study. MRI outcomes of interest included global (gray matter, total brain) and regional (lobar cortices, hippocampus) brain volumes, lateral ventricle volume, and total white matter hyperintensity (WMH) volume. All MRI measures were residualized for total cranial volume. Our main exposure was visit-1 sleep data (2008-2011), which includes information about SDB defined with the respiratory event index 3% (REI), ≥5 and ≥15 (moderate-severe SDB) identified by home-sleep apnea test. Survey linear regression models to assess the association between sleep measures and MRI outcomes adjusted for age, sex, education, Hispanic/Latino background, body mass index, tobacco use, alcohol consumption, and physical activity factors and accounted for HCHS/SOL complex study design. We tested for effect modifications by age, sex and Hispanic/Latino background. Results Mean age was 63.9±7.0 years. Adjusting for age, sex, and education, individuals with a REI ≥15 (vs. <5) had decrements in total brain volume (Btotal=-6.115[-10.19 ; -2.04]; p<0.01), total gray matter volume(B= -3.702 [-6.7 ; -0.7]; p<0.05), and frontal cortical gray matter volume (B= -1.844[-3.48; -0.21]; p<0.05), and increments in hippocampal volume β= 0.138[0.04; 0.23]; p<0.01). The associations persisted after adjustment for Hispanic/Latino background and behavioral risk factors. Older age modified associations between the REI and age and total brain volumes (Bage*REI=-0.019[-0.04 ;~0.00]; p<0.05). There was no consistent evidence for effect moderation by sex or Hispanic/Latino background. Conclusion In a diverse sample of Hispanic/Latinos, moderate-severe SDB was associated with decreased total brain volumes and increments in hippocampal volumes. Our findings suggest that SDB related neuroimaging markers of brain health could serve to identify Hispanic/Latino participants with sleep related Alzheimer’s disease and related dementia risk. Support (If Any) This work is supported by National Institute on Aging (R01AG048642, RF1AG054548, and R01AG063868) and by the National Heart Lung Blood Institute (R01HL098297). Dr. González also receives additional support from P30AG59299. The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-philip glass beck HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution-Office of Dietary Supplements.
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Johnson, Patricia. "Reviewer Acknowledgements for Studies in Media and Communication, Vol. 12, No. 1". Studies in Media and Communication 12, n.º 1 (26 de fevereiro de 2024): 476. http://dx.doi.org/10.11114/smc.v12i1.6764.
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Studies in Media and Communication (SMC) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether SMC publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 12 Number 1Abel Suing, Universidad Técnica Particular de Loja, EcuadorAina Fernàndez Aragonès, Tecnocampus-UPF, SpainÁlvaro Jiménez Sánchez, University of Valladolid, SpainAmie Jones, University of Georgia, USAAndré Iribure Rodrigues, Universidade Federal do Rio Grande do Sul, BrazilAndreas Veglis, Aristotle University of Thessaloniki, GreeceAnita Šulentić, Edward Bernays University College, CroatiaAntonio García Gómez, University of Alcalá de Henares, SpainAref AbuGweder, Achva Acadmic, IsraelAyşe Aslı Sezgin, Çukurova University, TurkeyBarira Bakhtawar, Information Technology University of the Punjab, PakistanBernard Naledzani Rasila, University of Venda, South AfricaBranco Di Fátima, University of Beira Interior (UBI), PortugalCamelia Cmeciu, Danubius University of Galati, RomaniaCarlos Serrano, University of Seville, SpainDaniel Moise, Bucharest University, RomaniaDi Zhang, Universiti Putra Malaysia, ChinaDonka Petrova, Sofia University “St. Kliment Ohridski”, BulgariaDorela Kaçauni, “Fan S. Noli” University, AlbaniaElsa Simões, Fernando Pessoa University, PortugalElsir Ali Saad Mohamed, Umm Al Quwain University, UAEErika Tiburcio Moreno, Carlos III University, SpainEva Solomon, University of Dar es Salaam, TanzaniaFrans Sayogie, Universitas Islam Negeri Syarif Hidayatullah Jakarta, IndonesiaFred Fang, South China Normal University, ChinaGebru Kahsay Kiflu, Adigrat University, EthiopiaGiorgio Poletti, University of Ferrara, ItalyGopolang Ditlhokwa, University of Botswana, BotswanaGordana Lesinger, Josip Juraj Strossmayer University in Osijek, CroatiaGraciela PadillaCastillo, Complutense University of Madrid, SpainGuanqin He, Utrecht University, JordanHarisur Rahman, North South University, BangladeshHerman, Universitas HKBP Nommensen Pematangsiantar, IndonesiaHsu Thiri Zaw, National Management Degree College, MyanmarImed Ben Labidi, Doha Institute for Graduate Studies, USAJarlene Rodrigues Reis, Cefet/RJ, BrazilJavier Serrano Puche, University of Navarra, SpainJianbo Hou, Xi'an International Studies University, ChinaJosé SixtoGarcía, University of Santiago de Compostela, SpainJosipa Bubaš, Independent Researcher, CroatiaKarim Ben Yahia, University of Bahrain, BahrainKhaled AlKassimi, American University in the Emirates, UAEKrešimir Žažar, University of Zagreb, CroatiaLei Ye, Hefei Normal University, ChinaLidia Peralta García, University of Granada, SpainLucia Zbihlejová, University of Presov, SlovakiaMaria de los Angeles Ferrer Mavarez, Universidad Tecnológica Metropolitana, ChileMaría Guadalupe Venteño, National Autonomous University of Mexico, MexicoMarina Klimenko, University of Florida, USAMarta Rizo García, Universidad Autónoma de la Ciudad de México, MexicoMasduki Masduki, Universitas Islam Indonesia, IndonesiaMatthias Degen, Westphalian University of Applied Sciences, GermanyMohammad Zamroni, Sunan Kalijaga State Islamic University, IndonesiaMunira Fayzulloeva, Tajik State University of Law, TajikistanNavarro Nicoletti Felipe, CONICETUniversidad Nacional de Rio Negro, ArgentinaNina Gunnarsson, Jönköping university, SwedenNingyang Chen, Soochow University, ChinaPablo Úrbez, Universidad Villanueva, SpainPatrick Neil M. Santiago, Nueva Ecija University of Science and Technology, PhilippinesPeggy Peattie, University of San Diego, USAPhilemon Bantimaroudis, University of Cyprus, CyprusRafael Ángel Rodríguez López, University of Malaga, SpainRafiza Luziani Varão Ribeiro Carvalho, University of Brasilia, BrazilRamez Abuhasirah, Middle East University, JordanRebeca SuarezAlvarez, Rey Juan Carlos University, SpainRocío del Pilar Sosa Fernández, University of Santiago de Compostela, SpainRonald Silalahi, Universitas Bunda Mulia, IndonesiaSarah Min, Dalton State College, USASeverin Mbog, University of Douala, CameroonStefan Markov, Sofia University, BulgariaThaïs de Mendonça Jorge, University of Brasilia, BrazilVeneza Mayora Ronsini, Federal University of Rio Grande do Sul, BrazilVladimir Dosev, University of Economics Varna, BulgariaXiao Li, Hubei Institute of Fine Arts, ChinaYi Luo, Montclair State University, USAYoung Joon Lim, University of Texas Rio Grande Valley, USAYudie Aprianto, Universitas Gadjah Mada, IndonesiaYuhan Wang, Guangdong University of Technology, ChinaZeinab Abulhul, George Mason University, USAZeynep Genel, İstanbul Okan University, Turkey Patricia JohnsonEditorial AssistantOn behalf of,The Editorial Board of Studies in Media and CommunicationRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://smc.redfame.com
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Hong, Mee Young, Sama Safadi, Andrew Gehr e Pia Asuncion. "Effects of Fresh Mango and Dried Mango Consumption on Satiety and Postprandial Glucose". Current Developments in Nutrition 6, Supplement_1 (junho de 2022): 287. http://dx.doi.org/10.1093/cdn/nzac053.028.
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Abstract Objectives Mangos are a nutrient-dense fruit containing high levels of various vitamins, minerals, dietary fiber, and bioactive phytochemicals (mangiferin, flavonoids, phenolic acids, and carotenoids). Many studies have investigated the beneficial effects of mango consumption through powders and extracts; however, few studies have examined fresh mango, specifically in contrast to the dried variety. The objective of the study was to determine the effects of fresh versus dried mango consumption on satiety levels and postprandial glucose. Methods In a randomized crossover design, 34 adults (29 females/5 males, age 25.0 ± 6.0 years, BMI 23. 8 ± 4.3 kg/m2) consumed 100 Kcal of fresh mangos, dried mango or white bread (control) on three separate occasions. Satiety was measured via a VAS (visual analogue scale) questionnaire at baseline and every 15 minutes for 90 minutes after snack consumption. Blood glucose measured via finger pricks was assessed at baseline and every 30 minutes for 90 minutes post snack consumption. Results Fresh mango consumption resulted in the greatest satiety increase (more fullness, less desire to eat) in participants. When compared to the dried mango and the bread, the fresh mango also significantly reduced the participants’ level of thirst. Furthermore, fresh mango promoted greater stability in blood glucose levels by exhibiting a more efficient decrease in postprandial glucose levels than dried mango or white bread (P < 0.05). Dried mango consumption also significantly lowered postprandial glucose compared to white bread (P < 0.05). Conclusions These results suggest that fresh mango consumption may be beneficial in reducing the risk of obesity and diabetes by improving satiety responses and postprandial glucose control, reducing food intake, and preventing weight gain. Funding Sources NUTR 302L Advanced Nutrition Laboratory, San Diego State University and The National Mango Board [#603,024].
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Connor, Ryan, Rodney Brister, Jan Buchmann, Ward Deboutte, Rob Edwards, Joan Martí-Carreras, Mike Tisza et al. "NCBI’s Virus Discovery Hackathon: Engaging Research Communities to Identify Cloud Infrastructure Requirements". Genes 10, n.º 9 (16 de setembro de 2019): 714. http://dx.doi.org/10.3390/genes10090714.
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A wealth of viral data sits untapped in publicly available metagenomic data sets when it might be extracted to create a usable index for the virological research community. We hypothesized that work of this complexity and scale could be done in a hackathon setting. Ten teams comprised of over 40 participants from six countries, assembled to create a crowd-sourced set of analysis and processing pipelines for a complex biological data set in a three-day event on the San Diego State University campus starting 9 January 2019. Prior to the hackathon, 141,676 metagenomic data sets from the National Center for Biotechnology Information (NCBI) Sequence Read Archive (SRA) were pre-assembled into contiguous assemblies (contigs) by NCBI staff. During the hackathon, a subset consisting of 2953 SRA data sets (approximately 55 million contigs) was selected, which were further filtered for a minimal length of 1 kb. This resulted in 4.2 million (Mio) contigs, which were aligned using BLAST against all known virus genomes, phylogenetically clustered and assigned metadata. Out of the 4.2 Mio contigs, 360,000 contigs were labeled with domains and an additional subset containing 4400 contigs was screened for virus or virus-like genes. The work yielded valuable insights into both SRA data and the cloud infrastructure required to support such efforts, revealing analysis bottlenecks and possible workarounds thereof. Mainly: (i) Conservative assemblies of SRA data improves initial analysis steps; (ii) existing bioinformatic software with weak multithreading/multicore support can be elevated by wrapper scripts to use all cores within a computing node; (iii) redesigning existing bioinformatic algorithms for a cloud infrastructure to facilitate its use for a wider audience; and (iv) a cloud infrastructure allows a diverse group of researchers to collaborate effectively. The scientific findings will be extended during a follow-up event. Here, we present the applied workflows, initial results, and lessons learned from the hackathon.
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Molina, Trisha, Samantha Johansen, Timothy Nishimura, Martin Jr Rosas, Kristine Giltvedt e Mee Young Hong. "Effects of Blenderized Watermelon With the Rind on Satiety, Bowel Movement, and Postprandial Glucose". Current Developments in Nutrition 5, Supplement_2 (junho de 2021): 348. http://dx.doi.org/10.1093/cdn/nzab037_058.
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Abstract Objectives Many studies have examined the beneficial effects of watermelon flesh on metabolic diseases, yet fewer studies have investigated the effects of watermelon rind. While normally discarded, rind consumption not only reduces food waste but contains fiber (pectin) and healthful bioactive compounds such as citrulline. This study examined the effects of watermelon rind consumption on postprandial glucose, satiety and bowel movements. It was hypothesized that consumption of blenderized watermelon juice with rind would lower postprandial glucose, increase satiety and improve bowel movement habits. Methods In a double-blind randomized crossover study, 21 participants (age 26.3 ± 5.7 y, BMI 22.6 ± 2.8 kg/m2) consumed one cup (8 fl. oz) of blenderized watermelon juice with or without rind. A visual analogue scale was used to measure satiety at baseline, immediately after, 20, 40, 60 and 90 minutes post juice consumption. Blood glucose was measured at baseline, 20, 40, 60 and 90 minutes post juice consumption. Bowel movement questionnaires were administered two days before and after each trial. Results Both blenderized watermelon juices (with and without rind) increased satiety with more fullness in watermelon juice with rind (P < 0.05). Watermelon juice with rind also stabilized blood glucose levels in comparison to watermelon juice (P < 0.001). No significant differences between the two trials for bowel movements were found, but no evidence of constipation or discomfort was presented among the participants. Conclusions These results suggest that watermelon juice with rind has favorable effects on postprandial glucose and satiety levels but no effect on bowel movements. Therefore, further research into the benefits of watermelon rind is important and could offer potential clinical applications and disease prevention. Funding Sources NUTR 302L Advanced Nutrition Laboratory San Diego State University and National Watermelon Promotion Board (NWPB 19–20).
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Anjum, T., e W. Akram. "First Record of Acremonium Wilt in Tomato from Pakistan". Plant Disease 98, n.º 1 (janeiro de 2014): 155. http://dx.doi.org/10.1094/pdis-02-13-0121-pdn.
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During a survey in May 2011, tomato (Lycopersicon esculentum Mill.) plants were observed exhibiting wilt symptoms on the vegetable farm of the University of the Punjab Lahore (31°32′59″ N, 74°20′37″ E), Pakistan. Plants were pale yellow and stunted. Diseased plants were scattered in the field either singly or in groups of two or three. Lower leaves turned yellow following necrosis and shedding from the plants. Roots of diseased plants were dark brown in comparison to the healthy ones. Vascular browning was observed when infected stems were split longitudinally and sectioned transversely. Necrotic vascular strands were also observed in infected stems. With a stereoscope, white hyphae were noticed in the vascular region of infected plants. Stained cross sections of stems of wilted plants showed fungal hypha. A diseased plant sample was taken to the First Fungal Culture Bank of Pakistan (FCBP) for identification of the pathogen. Conidia appeared on potato dextrose agar after incubation in diurnal light, and were unicellular, smooth, thin-walled, and oval in shape (3 to 6 × 1 to 3 μm), forming aggregations on the tip of conidiophores. With the help of diagnostic keys and available literature, the isolated fungus was identified as Acremonium strictum W. Gams. The fungus formed whitish flat colonies with deposition of gum granules on its surface. Hyphae and phialides were hyaline and non-pigmented. Phialides with expanded bottoms were elongated measuring 25 to 40 μm and solitary in position at right angles to the filament. To further confirm identification, amplification of the ITS1 and ITS2 regions was performed with universal primers ITS1 and ITS4 (4). The ITS sequence obtained was submitted to NCBI as accession JQ916901. The culture was deposited in FCBP (1099), Institute of Agricultural Sciences, University of the Punjab, Pakistan. A pathogenicity test of the isolated fungus was performed by inoculating 15 healthy tomato plants cv. Rio Grande in three replicates. The spore suspension (2 × 105 conidia/ml of sterile distilled water) was prepared from 12-day-old cultures of the fungus grown from a single spore on PDA in continuous light. Control plants were treated with sterile distilled water. Tomato plants inoculated with the fungus started showing wilting symptoms within 2 weeks, while the control remained healthy. A. strictum was re-isolated from inoculated wilted plants, thus satisfying Koch's postulates. Previously, A. strictum was a reported cause of wilt in many plants including Chrysanthemum maximum (2), watermelon (1), and Gladiolous grandiflorus (3). To our knowledge, wilt in tomatoes has been reported only from Fusarium oxysporum and Pseudomonas solanacearum from Pakistan. To our knowledge, this is the first record of Acremonium wilt in this economically important crop. References: (1) B. D. Bruton et al. Plant Dis. 79:754, 1995. (2) A. R. Chase. Calif. Agric. 32(10):21, 1978. (3) E. Gonzalez-Perez. J. Plant Pathol. 90:586, 2008. (4) T. J. White et al. Pages 315-322 in: PCR Protocols: A Guide to Methods and Applications. Academic Press, San Diego, CA, 1990.
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Fox, David J. "Lay J. Gibson and Alfonso Corona Rentería (eds.), The U.S. and Mexico: Borderland Development and the National Economies (Boulder and London: Westview Press, 1985, £38.50). pp. xviii+262. - Ina Rosenthal-Urey (ed.), Regional Impacts of U.S.–Mexican Relations (San Diego: Center for U.S.–Mexican Studies, University of California, Monograph Series, 16, 1986, n.p.s.). Pp. xviii+154. - Lawrence A. Herzog (ed.), Planning the International Border Metropolis: Trans Boundary Policy Options for the San Diego–Tijuana Region (San Diego: Center for U.S.–Mexican Studies, University of California, Monograph Series, 19, 1986, n.p.s.). Pp. vii+ 108." Journal of Latin American Studies 20, n.º 2 (novembro de 1988): 467–69. http://dx.doi.org/10.1017/s0022216x0000314x.
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Crandall, Russell. "Wayne A. Cornelius, Todd A. Eisenstadt, and Jane Hindley, eds. Sub-national Politics and Democratization in Mexico. San Diego: Center for U.S.-Mexican Studies, University of California, 1999. Tables, figures, notes, bibliographies, 369 pp.; paperback $21.95." Journal of Interamerican Studies and World Affairs 42, n.º 4 (2000): 149–51. http://dx.doi.org/10.2307/166351.
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GLEDHILL, J. "Transforming state-society relations in Mexico: The national solidarity strategy Cornelius, Wayne A., Craig, Ann L. and Fox, Jonathan (eds) (1994) Center for US-Mexican Studies, University of California (San Diego). xiii + 368 pp. Price not given". Bulletin of Latin American Research 14, n.º 3 (setembro de 1995): 397–99. http://dx.doi.org/10.1016/0261-3050(95)90065-9.
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Frable, Benjamin, Charlotte Seid, Greg Rouse e Philip Hastings. "Integration and Curation of At-Risk Collections into the Scripps Institution of Oceanography Collections". Biodiversity Information Science and Standards 2 (13 de junho de 2018): e26259. http://dx.doi.org/10.3897/biss.2.26259.
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The Scripps Institution of Oceanography (SIO) at the University of California, San Diego maintains one of the largest combined oceanographic collections in the world comprising four collections: Geological (sediment cores and dredged rocks), Pelagic Invertebrates, Benthic Invertebrates and Marine Vertebrates. After surviving threats of dissolution, the SIO Collections are now securely funded and have been able to make other collections available to the scientific community. Over the last few years, both the Marine Vertebrate (SIO-MVC) and Benthic Invertebrate (SIO-BIC) Collections have received National Science Foundation (NSF) and institutional funding to integrate important at-risk collections from University of California, Los Angeles (UCLA), the Monterey Bay Aquarium Research Institute (MBARI) and the University of Victoria. The UCLA Ichthyological Collection, around 9000 lots, was at risk of disposal due to hazardous material concerns and lack of institutional support. The collection, accumulated primarily under Boyd Walker (1949-1980) and later Don Buth (1980-), contains material from extensive surveys of the near-shore fishes of Southern California, Baja California and the Tropical Eastern Pacific including remote oceanic islands such as the Revillagigedos, Clipperton and the Galapagos. The UCLA collection also contains over 150 secondary types and over 100 species new to the SIO-MVC. Due to lack of support, the collection records were never digitized and the collection was minimally curated and its holdings were poorly known. For over two years, the collection manager and student employees have physically re-curated and integrated this material into the SIO-MVC. These data are now available online via iDigBio and VertNet and have already been used in numerous studies. The SIO-BIC, holding 45,000 lots, is accepting ownership of two deep-sea animal collections from Verena Tunnicliffe at the University of Victoria and Robert Vrijenhoek at MBARI. These collections include 10,900+ lots, largely from hydrothermal vents across the Pacific. Collected over 35 years from remote deep-sea sites that are difficult and expensive to access, these collections represent a major resource for systematics, genetics, and ecology. With Dr. Vrijenhoek now retired and Dr. Tunnicliffe nearing retirement, their collections were at risk of being lost. This material will be made discoverable online through the SIO-BIC database and iDigBio, and will be available for loan and examination. In the last year, the collection manager and five undergraduate employees have integrated some 3,000 lots. With support from the institution and the NSF, the SIO collections are solidifying their roles as central repositories for deep-sea and Eastern Pacific fauna.
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Zhang, Liyue, Kayla Buenaventura, Cassandra Wickstrom, Changqi Liu e Mee Young Hong. "Sensory Evaluation of Blenderized Watermelon Flesh Juice With and Without the Rind". Current Developments in Nutrition 5, Supplement_2 (junho de 2021): 616. http://dx.doi.org/10.1093/cdn/nzab044_047.
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Abstract Objectives Although the rind of a watermelon contains much of health benefiting nutrients, it is much less appreciated by consumers and is often disposed. The purpose of this study was to compare sensory properties of blenderized watermelon (WM) flesh juice with and without rind. Methods Twenty-three semi-trained college students (age 26.1 ± 6.0 y, BMI 22.7 ± 3.1 kg/m2, 18 females and 5 males) participated in the sensory evaluation of blenderized WM flesh juice with and without the rind. Participants were asked to identify the unique sample among three samples in a triangle test. In addition, participants rated color, consistency, smell, flavor, sweetness, mouthfeel, aftertaste, and acceptance of the two samples using a 7-point hedonic scale. Each sample was presented in a 2-ounce clear plastic condiment cup with a randomly assigned number. Panelists were asked to rinse their mouths with water before assessing each sample. The triangle test and hedonic scaling were analyzed by binomial analysis and t-test, respectively. Results The majority of the panel (21 out of 23 panelists) could distinguish the odd sample from the other samples in the triangle test (P < 0.001), indicating that participants could correctly discriminate between the blenderized WM juice with and without the rind. Participants preferred the color, consistency, smell, flavor, sweetness, mouthfeel, and aftertaste of the WM flesh juice to those of the WM flesh juice with rind (P < 0.01). The 7-point hedonic scale showed an average overall acceptance score of 5.0 for the blenderized WM juice and a score of 3.8 for the blenderized WM juice with rind (P < 0.001). Conclusions The blenderized WM juice exhibited more desirable sensory attributes than the WM juice with rind. It is thus imperative to improve the sensory quality of the WM juice with rind in order to promote it as a nutrient-dense and sustainable food. Funding Sources NUTR 302L Advanced Nutrition Laboratory, San Diego State University. National Watermelon Promotion Board (#NWPB 19–20).
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Hembruff, Stacey L., Alexander Dekonenko, John Thyfault, Mihaela Sardiu, Michael Washburn, Roy A. Jensen e Lisa M. Harlan-Williams. "Abstract 1785: The role of BRCA1 on metabolic pathways in an in vivo system". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 1785. http://dx.doi.org/10.1158/1538-7445.am2024-1785.
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Abstract The role of BRCA1 in cellular metabolism is not well characterized and what we do understand has been mostly demonstrated in vitro. Our studies aim to fully characterize the role of BRCA1 in metabolic pathways in a whole-body system. In vivo studies using C57BL/6 wild-type and transgenic humanized BRCA1 mice demonstrate the effect of human BRCA1 on the whole-body metabolic phenotype and start to elucidate the mechanism by which this occurs. We used Promethion metabolic chambers and glucose tolerance tests to measure a number of metabolic outputs of male and female mice that had either normal mouse Brca1 gene expression (wild-type/WT mice) or a knock-out mouse Brca1/knock-in human BRCA1 (humanized/HU mice). Humanized BRCA1 mice are more lean, hyperactive and demonstrate a sexual dimorphism in glucose tolerance when compared to wild-type mice on the same genetic background. To begin to elucidate the mechanisms behind the observed metabolic phenotype, we used a metabolic tissue, female mouse skeletal muscle, to perform mass spectrometry, SuperArray, and Western blot analysis. Proteomic samples were sent to the IDeA National Resource for Quantitative Proteomics at the University of Arkansas Medical Sciences for processing and analysis. Proteomic and genomic analysis showed changes in a number of metabolic pathways that may be implicated in the observed whole body metabolic phenotype. We can conclude that changing the expression levels of BRCA1 in an in vivo model altered the overall metabolic profile of C57BL/6 mice. This is the first in vivo evidence demonstrating the effects of BRCA1 expression in whole body metabolism. Citation Format: Stacey L. Hembruff, Alexander Dekonenko, John Thyfault, Mihaela Sardiu, Michael Washburn, Roy A. Jensen, Lisa M. Harlan-Williams. The role of BRCA1 on metabolic pathways in an in vivo system [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1785.
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Lee, Olivia W., Danielle Karyadi, Stephen Hartley, Weyin Zhou, Mitchell Machiela, Mykola Tronko, Tetiana Bogdanova, Liudmyla Zurnadzhy, Lindsay Morton e Stephen Chanock. "Abstract 1762: Characterization of somatic copy number deletion of chromosome 22q in papillary thyroid carcinoma". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 1762. http://dx.doi.org/10.1158/1538-7445.am2024-1762.
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Abstract Deletion in the long arm of chromosome 22 (22qDEL) is the most prevalent somatic copy number alteration (SCNA) observed in papillary thyroid carcinoma (PTC). Despite its recurrence, the specific characteristics and role of 22qDEL in PTC have not been fully studied. We conducted a pooled analysis of 22qDEL by integrating patient and clinical information and molecular profiles from 1,094 primary PTC tumors across four major published PTC genomic studies: The Cancer Genome Atlas (TCGA) PTC profile study, the National Cancer Institute (NCI) post-Chornobyl PTC study, the Memorial Sloan Kettering Cancer Center Integrated Mutation Profiling of Actionable Cancer Targets (MSKCC-IMPACT) PTC cases, and the Seoul National University (SNU) thyroid cancer profile study. The majority of PTC with 22qDEL demonstrated arm-level loss of heterozygosity (86%). Even in PTC cases with partial 22qDEL, we observed a loss across 70% of chromosome 22, encompassing regions 22q12 and 22q13, which harbors known cancer genes (NF2 and CHEK2). More than 90% of 22qDEL co-occurred with established oncogenic drivers of PTC, though a full assessment of PTC drivers was not available for all cases. 22qDEL occurred more frequently with RAS point mutations (50.4%) than other drivers (9.3%). A higher fraction of 22qDEL was clonal in RAS-driven PTCs (78.3%), suggesting 22qDEL occurs early in RAS-driven tumor development. We did not observe any association between 22qDEL and established PTC risk factors such as age, sex, and radiation, nor with clinical features including tumor size, multifocality, and metastasis (p-values>0.22). RNA sequencing gene expression analysis based on 22qDEL status revealed downregulation of most genes residing on chromosome 22q and significant differential expression activity of immune-related genes, further implicating a role of immune dysregulation in PTC. Our study suggests that 22qDEL may not act as a primary driver of PTC but plays an important role as a co-factor of RAS point mutations, which could further drive PTC development. Citation Format: Olivia W. Lee, Danielle Karyadi, Stephen Hartley, Weyin Zhou, Mitchell Machiela, Mykola Tronko, Tetiana Bogdanova, Liudmyla Zurnadzhy, Lindsay Morton, Stephen Chanock. Characterization of somatic copy number deletion of chromosome 22q in papillary thyroid carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1762.
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Lugovyi, Volodymyr, Olena Slyusarenko e Zhanneta Talanova. "Development of university research potential as the basis of competitive quality of higher education in the United States: experience for Ukraine". International Scientific Journal of Universities and Leadership, n.º 11 (14 de junho de 2021): 86–115. http://dx.doi.org/10.31874/2520-6702-2021-11-1-86-115.
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The development of University research potential (URP) in the USA during 1950-2020 in view of achieving competitive quality of higher education is analysed in the article.
The national deterministic context and components of this potential by the types of activity (educational, research) and by the resources (personnel, financial, organizational) as well as component impact on the highest excellence quality of education (according to the criteria of the Academic Ranking of World Universities, ARWU) are identified. It is proved that the context of URP development is dichotomous and consists of national spheres of education and research. This assertion corresponds to the duality of higher education (as an integrated intersection of education and research) and the composition and structure of higher education mission (list of interrelated keywords and the order of their priority: education, research, creativity / innovation).
It is substantiated that URP is first actualized within study programmes of the highest level of complexity (Master's, PhD and Postdoctoral), research activity of academic staff (especially professors) and research organizations associated with Universities (institutes, centres, laboratories, clinics). This reasoning conforms to the concept and criteria for research and doctoral Universities in line with the Carnegie Classification. These components are integrated into the educational process to varying degrees, so they have a different impact on the quality of education. For the first 30 top US Universities, there is no probable correlation between ranking achievements and the amount of research and developments (R&D) funding as well as the number of researchers in institutions. Instead, such correlation is strong for the number of Postdoctorates in an institution.
In general, there is a steady trend of downward in the share of the higher education sector within R&D performance in the US that amounted to 12.0 % in 2019. Although scale of higher education sector share is still growing quantitatively and is the basis for modernizing education content. At the same time, Master's, PhD and Postdoctoral programmes are spreading at a significant pace. In the 1959/60 academic year, the ratio of the number of awarded Bachelor's, Master's and PhD degrees was 1 : 27 : 7.5, in 2018/19 – 1 : 41 : 9.3 under multiple times increased graduation. Between 1979 and 2019, the number of Postdoctorates increased 3.7 times. Salaries of academic staff, especially professors, are increased, academic staff workload is minimized and subject-oriented, a system of permanent employment is proposed, and a modern educational, research, and information infrastructure is created for effective research and research-based education activity.
The national context of the development of URP is stably favourable given the increase in the share of GDP for the funding of education institutions in general, higher education institutions in particular, and R&D especially. The corresponding expenditures reached 7.1 %, 3.0 % and 3.1 % GDP and are the largest ones quantitatively in the world. Purposeful and consolidated (federal, business, university, public) support for education and R&D has been and is provided in critical periods of the country's competitive struggle for leadership in an innovatively progressive world. The state of these spheres, in particular higher education, and URP, is systematically examined. The decades of the 1960s of the last century and the twenties of the present century are significant. In the 1960s, the share of GDP for the higher education institutions funding was doubled, the number of awarded Master's degrees was increased almost tripled, and the award of PhD degrees was increased six times to overcome the threat of educational and scientific backwardness. R&D funding reached 2.8 % of GDP, of which 1.9 % came from the federal budget. Funding for Universities’ R&D has increased 3.6 times. The super-powerful public University of California, San Diego (1960), 9 other world-class Universities, and 6 subworld-class Universities according to the ARWU, the National Academy of Engineering (1964), and the National Academy of Education (1965) were established.
The characteristics of state, monitoring and development policy of the URP and educational and research context in the US is a guideline for the improvement of Ukrainian Universities.
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LOAEZA, SOLEDAD. "Kevin J. Middlebrook (ed.), Party Politics and the Struggle for Democracy in Mexico: National and State-Level Analyses of the Partido Acción Nacional (La Jolla, CA: Center for US-Mexican Studies, University of California, San Diego, 2001), pp. x+278, pb." Journal of Latin American Studies 36, n.º 1 (fevereiro de 2004): 181–84. http://dx.doi.org/10.1017/s0022216x03417689.
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Zhang, Ying, Debby Ngo, Bing Yu, Neomi Shah, Han Chen, Alberto Ramos, Phylis Zee et al. "0030 Development and Validation of a Metabolomic Risk Score for Obstructive Sleep Apnea across Race/Ethnicities". Sleep 45, Supplement_1 (25 de maio de 2022): A13—A14. http://dx.doi.org/10.1093/sleep/zsac079.029.
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Abstract Introduction Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of upper airway obstruction during sleep resulting in oxygen desaturation and sleep fragmentation, and associated with increased risk of adverse health outcomes. Metabolites are being increasingly used for biomarker discovery and evaluation of disease processes and progression. We aimed to develop a metabolomic risk score (MRS) for OSA and identify individual metabolites associated with OSA to provide insights into the pathogenesis of OSA. Methods We studied 219 metabolites and their associations the apnea hypopnea index (AHI) and with OSA, defined as AHI , in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (n=3507) using two methods: (1) association analysis of individual metabolites, and (2) least absolute shrinkage and selection operator (LASSO) regression to identify a subset of metabolites that are jointly associated with OSA, and develop an MRS. We then validated the results in Multi-Ethnic Study of Atherosclerosis (MESA) (n=475), an independent dataset. Results HCHS/SOL participants were 41.72 years old on average, 50.7% female, and 10.2% had OSA. MESA individuals were 68.45 years old on average, 56.2% females, and 46.7% had OSA. When assessing the associations between OSA/AHI and individual metabolites, we identified seven metabolites significantly and positively associated with OSA in HCHS/SOL (FDR p<0.05), of which four associations - glutamate, oleoyl-linoleoyl-glycerol (18:1/18:2) (DAG(36:3)), linoleoyl-linoleoyl-glycerol (18:2/18:2) (DAG(36:4)) and phenylalanine, replicated in MESA (one sided-p value<0.05). The OSA-MRS, composed of 14 metabolites, was associated with 52% increase of risk for moderate to severe OSA (OR=1.52 [95% CI: 1.23-1.87] per 1 SD of OSA-MRS, p<.001) in the discovery dataset of HCHS/SOL and 44% increased risk (OR=1.44 [95% CI: 1.03-2.03] per 1 SD of OSA-MRS, p=0.034) in the validation dataset of MESA, both adjusted for demographic, lifestyle, and comorbidities. Similar albeit less significant associations were observed for AHI modeled continuously. Conclusion We developed an MRS that replicated in an independent multi-ethnic dataset, demonstrating the robustness of metabolomic-based OSA risk score to population heterogeneity. Replicated metabolite associations may provide insights into OSA-related molecular and metabolic mechanisms. Support (If Any) Support for metabolomics data was graciously provided by the JLH Foundation (Houston, Texas). The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. The authors thank the staff and participants of HCHS/SOL for their important contributions. MESA and the MESA SHARe project are conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with MESA investigators. Support for MESA is provided by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, UL1-TR-000040, UL1-TR-001079, UL1-TR-001420. MESA Family is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with MESA investigators. Support is provided by grants and contracts R01HL071051, R01HL071205, R01HL071250, R01HL071251, R01HL071258, R01HL071259, and by the National Center for Research Resources, Grant UL1RR033176. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR001881, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research Center. Molecular data for the Trans-Omics in Precision Medicine (TOPMed) program was supported by the National Heart, Lung and Blood Institute (NHLBI). ). Metabolomics for “NHLBI TOPMed: Multi-Ethnic Study of Atherosclerosis (MESA)” (phs001416) was performed at Broad Institute and Beth Israel Metabolomics Platform (HHSN268201600038I). Core support including centralized genomic read mapping and genotype calling, along with variant quality metrics and filtering were provided by the TOPMed Informatics Research Center (3R01HL-117626-02S1; contract HHSN268201800002I). Core support including phenotype harmonization, data management, sample-identity QC, and general program coordination were provided by the TOPMed Data Coordinating Center (R01HL-120393; U01HL-120393; contract HHSN268201800001I). We gratefully acknowledge the studies and participants who provided biological samples and data for TOPMed. This study was supported by NHLBI grant R35HL135818.
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Srivastava, Tanvi, Salma Shariff-Marco, Samuel L. Washington, Christine Miaskowski e June M. Chan. "Abstract 4827: Financial toxicity among cancer survivors during the COVID-19 pandemic". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 4827. http://dx.doi.org/10.1158/1538-7445.am2024-4827.
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Abstract Background: Financial toxicity (FT), the financial impact of cancer and its treatments on patients’ employment, income, and health insurance, can have significant short- and long-term consequences for cancer survivors. With significant increases in cancer survivorship and the changing demographics of the United States, a need exists to identify those most susceptible to FT. This study evaluated FT prevalence during the COVID-19 pandemic and identified factors associated with greater FT risk. Methods: Data were collected from 1,147 cancer survivors recruited from previous National Cancer Institute-funded studies, from electronic health record searches for patients with cancer diagnoses at University of California, San Francisco (UCSF) and Mount Sinai Medical Center and Columbia University Medical Center in New York City, and the Dr. Susan Love Foundation for Breast Cancer Research. Adults, diagnosed with cancer and proficient in English, completed an online survey via the Research Electronic Data Capture (REDCap) system between May 27, 2020 and February 21, 2021. FT was assessed for the past 14 days using the validated 11-item COmprehensive Score for financial Toxicity (COST) measure. Patients were categorized by score: no FT (COST scores >25), mild FT (14-25), and moderate/severe FT (0-13). Using Pearson’s chi-square test of independence, and univariate ordinal logistic regression, the study evaluated sociodemographic and clinical characteristics associated with FT, including age, race and ethnicity, gender, household income, education, marital status, health insurance status, and cancer site. Results: The COST measure had excellent reliability for the sample (Cronbach’s alpha = 0.911). Overall, 9% of respondents reported moderate/severe FT (MSFT), 16% mild. Race/ethnicity, education level, annual household income, cancer site, and years from diagnosis (p-values ≤ 0.035) were associated with FT. Current health insurance coverage was not associated with FT (p=0.456). 18% Black, 13% Asian American, 17% mixed, and 20% other races/ethnicities reported MSFT, while 8% non-Hispanic White and 5% Hispanic respondents reported the same. 31% of survivors with annual household income <$40,000 reported MSFT vs. 7% with ≥$40,000 income. 14% of survivors with less than a college degree reported MSFT vs. 8% amongst those with a college degree or higher. For men, the odds of having FT (mild or MSFT) were 0.60 (95% CI 0.40, 0.90) times that of women. Survivors <50 years old at diagnosis had 7.53 (95% CI 4.09, 13.83) times the odds of FT (mild or MSFT) vs. those aged ≥75 years. Conclusions: These preliminary analyses from this cross-sectional study characterizes the prevalence and determinants of FT experienced by cancer survivors during the COVID-19 pandemic. The next steps will include multivariable analysis and comparison with pre-pandemic data, to identify those at greatest risk and inform interventions. Citation Format: Tanvi Srivastava, Salma Shariff-Marco, Samuel L. Washington, Christine Miaskowski, June M. Chan. Financial toxicity among cancer survivors during the COVID-19 pandemic [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4827.
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Tay, Joshua K., Wei Keat Teo, Joseph W. Foley, Luvita Suryani, Bing Cheng Wu, Chor Hiang Siow e Kwok Seng Loh. "Abstract 5660: Gene expression signatures from FFPE to predict recurrent metastatic nasopharyngeal cancer". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 5660. http://dx.doi.org/10.1158/1538-7445.am2024-5660.
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Abstract Nasopharyngeal cancer (NPC) is an EBV-driven epithelial cancer endemic to Southeast Asia, Southern China and the Middle East. Accurate profiling of the gene expression of NPC has been challenging because of its intense inflammatory infiltrate, as well as the 3 - 4mm size of biopsies limiting the amount of available material. Here we present a large cohort of 339 micro-dissected gene expression libraries from formalin-fixed paraffin-embedded (FFPE) biopsies from NPC patients treated at the National University Health System, Singapore, as well as healthy controls. NPC tumors from patients who subsequently developed recurrent or metastatic disease (Group A), and patients who did not develop recurrent or metastatic disease (Group B) were profiled. Tumor epithelial and microenvironment compartments were separately obtained using laser-capture microdissection, followed by library preparation performed for RNA-Seq using an in-house specialised technique. Gene signatures for NPC tumor epithelial and microenvironment content were used to validate the purity of gene expression libraries. Our preliminary analysis revealed that primary, pre-treatment tumors from patients who subsequently developed recurrence (Group A) showed downregulation of processes related to interferon gamma and interferon alpha response (p-adj <0.001 for both), while processes related to epithelial-mesenchymal transition (p-adj < 0.05) were enriched compared to patients who remained healthy (Group B). In contrast to primary tumors, recurrent tumors in Group A were enriched for cellular respiration including oxidative phosphorylation (p-adj < 0.0001). Our approach highlights the utility of whole transcriptome profiling from small quantities of archival FFPE material. The gene signatures identified from the primary tumors of high-risk patients are biologically relevant and have the potential to be used in precision medicine to guide additional targeted intervention. Citation Format: Joshua K. Tay, Wei Keat Teo, Joseph W. Foley, Luvita Suryani, Bing Cheng Wu, Chor Hiang Siow, Kwok Seng Loh. Gene expression signatures from FFPE to predict recurrent metastatic nasopharyngeal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5660.
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Yun, Dabin, Jung-Ho Yang, Sun-Seong Kweon, Jin-ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin e Nan Song. "Abstract 6150: MMP14 and MKLN1 as colorectal cancer susceptibility genes and a drug repurposing candidate from genome-wide association study in South Korea". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 6150. http://dx.doi.org/10.1158/1538-7445.am2024-6150.
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Abstract Background: One of the major topics about colorectal cancer (CRC) is to find susceptible genes. Furthermore, functional interpretation of post-GWAS analysis gains attention and various approaches to find drug-repurposing candidates are used in cancer research. Our study aims to identify susceptible genes for CRC and provide drug-repurposing candidates. Methods: CRC patients in Seoul National University Hospital with prospective follow-up were recruited. From blood-derived DNA, genome-wide SNPs were genotyped using the Korea Biobank Array and 409,063 SNPs were extracted. SNP-based logistic regression model was fit for the event of CRC estimating beta values. Furthermore, post-GWAS analysis was conducted using regulatory function, multiple annotation and gene expression database. Drug-repurposing candidate was identified through the pre-trained deep neural network with susceptible genes. Results: We used 500 participants of CRC cases and 1,500 participants of healthy controls. For GWAS, statistically significant associations were mapped to MKLN1, MMP14, PTPN14 and MKL2 genes. For post-GWAS analysis, strong associations were found for MKLN1 (rs75170436, 7q32.3, Beta=-0.90, P-value=5.90×10-13) and MMP14 (rs3751489, 14q11.2, Beta=-1.91, P-value=2.31×10-12). From the drug-repurposing analysis, PPARδ/β agonist (GW0742; Binding score=3.79(MKLN1), 12.06(MMP14)) was identified for both genes with the highest score. Conclusions: We revealed MKLN1 and MMP14 genes as susceptible genes associated with CRC development. Additionally, we identified PPARδ/β agonist (GW0742) as a drug-repurposing candidate for the treatment of CRC. These findings can promote the understanding of CRC development and provide a novel therapeutic candidate for CRC patients in the future. Citation Format: Dabin Yun, Jung-Ho Yang, Sun-Seong Kweon, Jin-ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin, Nan Song. MMP14 and MKLN1 as colorectal cancer susceptibility genes and a drug repurposing candidate from genome-wide association study in South Korea [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6150.
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Viallon, J., T. Choteau, E. Flores, F. Idrees, P. Moussay, R. I. Wielgosz, Christina M. Harth et al. "CCQM-P206, nitrous oxide (N2O) in air, ambient level, pilot study run in parallel with CCQM-K68.2019". Metrologia 60, n.º 1A (1 de janeiro de 2023): 08013. http://dx.doi.org/10.1088/0026-1394/60/1a/08013.
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Main text The Pilot Study CCQM-P206 was conducted in parallel with the Key Comparison CCQM-K68.2019, which was aimed at evaluating the level of comparability of laboratories' capabilities for nitrous oxide in air primary reference mixtures at ambient amount fractions, in the range 320 nmol mol−1 to 350 nmol mol−1. The Pilot Study was set up to allow the participation of the Scripps Institution of Oceanography of the University of California San Diego (SIO/UCSD) as guest expert laboratory of the CCQM. The SIO/UCSD was invited by the CCQM in view of its long experience in accurate measurements of nitrous oxide in the atmosphere and is the calibration laboratory for this compound in the AGAGE (Advanced Global Atmospheric Gases Experiment) global measurement network. The laboratory has developed a unique method which provides an independent assessment of the N2O amount fraction compared to participants in CCQM-K68.2019. Its participation was also seen as the occasion to contribute to a more general reflexion on the compared advantages of two different systems to ensure traceability: a unique scale maintained by one central laboratory, or the dissemination of materials all traceable to the SI by multiple national metrology institutes. The comparison CCQM-K68.2019 was coordinated by the BIPM and the KRISS. It consisted in the simultaneous comparison of a suite of 2n primary gas standards, two standards to be prepared by each of the n participating laboratories. Two independent analytical methods were used by the BIPM to analyse the amount fraction of N2O in air, namely Gas Chromatography with an Electron Capture Detector (GC−ECD) and Quantum Cascade Laser Absorption Spectroscopy (QCLAS). For the Pilot Study, SIO/UCSD provided results of measurements of the N2O amount fraction in the two standards submitted by the Global Monitoring Laboratory of the National Oceanic and Atmospheric Administration (NOAA), a participant in the Key Comparison. Therefore, this study consists in looking at the agreement between SIO/UCSD measurement results and the Key Comparison reference value. All details on the Key Comparison CCQM-K68.2019, including its protocol and its results, can be found in its report. This report focuses on SIO/UCSD results and agreement with participants in the Key Comparison. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/. The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
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Lee, H. B., C. J. Kim, H. Y. Mun e K. H. Lee. "First Report of Erysiphe quercicola Causing Powdery Mildew on Ubame Oak in Korea". Plant Disease 95, n.º 1 (janeiro de 2011): 77. http://dx.doi.org/10.1094/pdis-05-10-0396.
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Ubame oak (Quercus phillyraeoides A. Gray) is native to eastern Asia, including China, Korea, and Japan. In 2009 and 2010, a powdery mildew on Q. phillyraeoides growing in clusters and singly was observed in three locations on the campus of Chonnam National University, Gwangju, Korea. White superficial conidia of the powdery mildew fungus occurred on adaxial and abaxial surfaces. However, the white powdery growth was more abundant on the adaxial surface. Leaf symptoms commonly appeared white from May to October. Along with the typical white powdery mildew, spot and/or necrotic symptoms with irregular violet-to-wine red surfaces were also frequently observed on overwintered leaves. A voucher specimen has been deposited in EML (Environmental Microbiology Laboratory) herbarium collection, Chonnam National University (EML-QUP1). Conidia were commonly formed singly but also occurred in chains. Primary conidia were obovoid to ellipsoid, with a rounded apex and subtruncate base. Secondary conidia were generally obovoid to ellipsoid or sometimes cylindrical but dolioform when mature. The size was 30.1 to 43.2 (average 37.7) × 14.1 to 21.1 (average 18.1) μm with length/width ratio of 1.8 to 2.4 (average 2.1). Conidiophores were erect and up to 102.2 μm long. No chasmothecia were found. From extracted genomic DNA, the internal transcribed spacer (ITS) region inclusive of 5.8S rDNA was amplified with ITS1F (5′-CTTGGT CATTTAGAGGAAGT-3′) and LR5F (5′-GCTATCCTGAGGGAAAC-3′) primers (4). Sequence analysis by BLASTN search indicated that EML-QUP1 (GenBank Accession No. HQ328834) was closest to E. quercicola (GenBank Accession No. AB292691) with >99% identity (478 of 480), forming a monophyletic quercicola clade in the resulting phylogenetic analysis. The causal fungus was determined to be Erysiphe quercicola on the basis of morphology and sequence data analysis. Major genera including Cystotheca, Erysiphe, Microsphaera, and Phyllactinia have been reported to cause powdery mildews on Quercus plants. Until now, 22 Erysiphe species including E. abbreviata, E. alphitoides, E. calocladophora, E. gracilis, E. polygoni, and E. quercicola have been reported to cause powdery mildews on Quercus spp. (1). Of these, four Erysiphe species including E. alphitoides, E. gracilis, E. quercicola, and an unidentified Erysiphe sp. have been found on Q. phillyraeoides from Japan (1–3). E. quercicola was reported to occur on five Quercus species: Q. crispula, Q. phillyraeoides, and Q. serrata in Japan, Q. robur in Australia, and Quercus sp. in Australia, Iran, and Thailand (1). To our knowledge, this is the first report of leaf powdery mildew caused by E. quercicola on Q. phillyraeoides in Korea. References: (1) D. F. Farr and A. Y. Rossman. Fungal Databases, Systematic Mycology and Microbiology Laboratory, ARS, USDA. Retrieved October 7, 2010, from http://nt.ars-grin.gov/fungaldatabases/ , 2010. (2) S. Limkaisang et al. Mycoscience 47:327, 2006. (3) S. Takamatsu et al. Mycol. Res. 111:809, 2007. (4) T. J. White et al. PCR Protocols: A Guide to Methods and Applications. Academic Press, San Diego, 1990.
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Willingham Jr., Mark Lee, Kevin D. Cassel, Angela Sy, Munirih Taafaki, Tressa P. Diaz, Antoinette Kleiner e Angelina Mummert. "Abstract 3472: Tailored cancer outreach efforts of a community outreach core working with Native Hawaiian and Pacific Islanders in Hawaiʻi". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 3472. http://dx.doi.org/10.1158/1538-7445.am2024-3472.
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Abstract Background The Community Outreach Core (COC) of the Pacific Island Partnership for Cancer Health Equity (PIPCHE) aims to improve health equity for historically underserved populations including Native Hawaiians and other Pacific Islanders (NHOPIs), and Filipinos. PIPCHE is a partnership between the University of Hawai’i Cancer Center and the University of Guam whose efforts are focused in Hawaiʻi, Guam and the U.S. Affiliated Pacific Islands (USAPI). The COC directly addresses the disproportionately high rates of health disparities and cancer incidence and mortality found within NHOPIs often due to multiple complex historical, social, cultural, and environmental factors. Cancer is the second leading cause of death in Hawai’i between 2014-2018, as well as the second most common cause of death in nearly all USAPI jurisdictions. The COC uses research-tested, community-engaged approaches to modify determinants of cancer in these groups. Methods Outreach efforts have addressed NHOPI cancer inequities by raising awareness of high cancer burdens experienced by these underserved communities. Efforts include resource sharing and data collection at various venues in Hawaiʻi such as health/wellness fairs, public housing, and Pacific Islander churches. Outreach Advisory Council meetings were held biannually with community health leaders to discuss ongoing and future initiatives/resource sharing. The COC provided health providers and students with cultural competency training on more efficient strategies to work with these unique NHOPI groups. The COC provided presentations and short talks across the U.S, including a Health Providers Symposium on lung cancer across the Pacific. Outreach efforts have included tailored NCI-based Screen to Save (S2S) colorectal cancer education to NHOPIs. Results Forty-seven major outreach events were conducted from 2021 to November 2023. These include: 1 Health Providers’ Cancer Symposium, 5 Outreach Advisory Council meetings, 5 Cultural Competency trainings and class lectures, 11 conference/community and short talk presentations, and 25 community outreach events. There were 1,900 attendees reached during these regional and national outreach activities. The COC works with professional audiences at the national level to inform these groups about cancer and the health burdens of NHOPIs. A total of 97 Pacific Islanders received the S2S education and completed a pre-posttest with positive increases in means found for all 14 questions. Conclusion The PIPCHE COC has been able to reach NHOPIs though community partnerships to deliver culturally tailored cancer prevention education and efforts within Hawaiʻi, as well as shed light nationally of the cancer burdens these populations face. The S2S education has been able to raise awareness of cancer screenings and holds promise as a potential strategy to address cancer burdens of NHOPI communities. Citation Format: Mark Lee Willingham Jr., Kevin D. Cassel, Angela Sy, Munirih Taafaki, Tressa P. Diaz, Antoinette Kleiner, Angelina Mummert. Tailored cancer outreach efforts of a community outreach core working with Native Hawaiian and Pacific Islanders in Hawaiʻi [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3472.
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Cheng, Yunzhong, Honghao Yang, Li Guan, Yong Hai e Aixing Pan. "Bibliometric and Visualized Analyses of Research Studies on Different Analgesics in the Treatment of Orthopedic Postoperative Pain". Pain Research and Management 2022 (24 de fevereiro de 2022): 1–10. http://dx.doi.org/10.1155/2022/6835219.
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Background. Pain following orthopedic surgery has always been a critical issue, which caused great distress to the patients. Analgesics in the treatment of postoperative pain following orthopedic surgery have aroused great attention from scholars, and numerous studies have been published in recent years. Bibliometrics could assist scholars in understanding the scope of research topics better, identifying research focuses and key literature, and analyzing the development and trend of analgesics in the treatment of postoperative pain following orthopedic surgery. Methods. Literature data were retrieved from the Science Citation Index Expanded (SCI-E) of Web of Science (WOS) Core collection database. The articles from 1992 to December 2021 on analgesics in the treatment of postoperative pain following orthopedic surgery were recruited. The citation reports including the publication numbers, h-index, total citations, and average citations in terms of authors, organizations, and countries were obtained. Top 20 research directions, funds, and journals with the most publications were charted. The co-authorship relations in the analysis units of authors, organizations, and countries were analyzed by the online bibliometric tool and VOSviewer software. The author’s keywords co-occurrence overlay map was visualized by the VOSviewer software. Results. A total of 406 articles were retrieved from 1992 to December 4th, 2021, with 11,655 times cited, average citations of 28.57 per item, and an h-index of 55. The most high-yield publication year, authors, organizations, countries, research directions, funds, and journals were 2020 (n = 887), Ilfeld BM from University of California San Diego (n = 7), University of California System (n = 21), the USA (n = 178), Anesthesiology (n = 161), National Institutes of Health (NIH), USA, and United States Department of Health Human Services (n = 12), and Anesthesia and Analgesia (n = 29), respectively. Similarly, co-authoring analysis of publications regarding on different analgesics showed that the authors and countries with the most co-authorship strength were Carr Daniel B (total link strength = 6) and the USA (total link strength = 30), respectively. The highest occurrence keywords were “postoperative pain” with 135 occurrences (total link strength = 784). The future research hotspots might be “acute pain,” “outcomes,” “oxycodone,” “total hip,” “replacement,” and “United States.” Conclusion. Analgesics in the treatment of postoperative pain following orthopedic surgery can be observed in this study by employing the online bibliometric tool and VOSviewer software, which established the relationship between the units of analysis. It can provide a meaningful resource with detailed information for orthopedic surgeons who would like to understand the trend in this field better. They can also benefit from the emphasis on citation count to carry out high-level research in the future.
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Cheng, Kevin, Mehdi Nouraie, Xiaomei Niu, Evadne Moore-King, Margaret F. Fadojutimi-Akinsi, Oswaldo L. Castro e Victor R. Gordeuk. "Inflammation, Multiple Blood Transfusions and Osteoclast Activation in Sickle Cell Disease Patients." Blood 114, n.º 22 (20 de novembro de 2009): 1534. http://dx.doi.org/10.1182/blood.v114.22.1534.1534.
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Abstract Abstract 1534 Poster Board I-557 Background Low bone mass density affects more than 65% of adult sickle cell disease patients and correlates with lower hemoglobin and higher ferritin concentrations (1). Increased iron supply promotes osteoclast differentiation and bone resorption (2). Proinflammatory cytokines also promote bone resorption (3). Tartrate resistant acid phosphatase isoform 5b (TRACP-5b) is produced only by activated osteoclasts and therefore serves as a marker of bone resorption (4). Sickle cell disease is a condition of chronic inflammation and patients often suffer from transfusional iron overload as well. In this study we aimed to determine the predictors of bone resorption in patients with sickle cell disease by measuring circulating levels of TRACP-5b. Methods Fifty-nine adult sickle cell disease patients and 22 apparently healthy controls were recruited at Howard University Hospital. Patients were at steady state with no crisis, hospitalization or blood transfusion in the last 3 weeks. Clinical and laboratory information was collected at the time of recruitment and TRACP-5b was measured in non-fasting serum samples using an enzyme immuno assay kit (Quidel, San Diego, CA). Serum concentrations of inflammatory cytokines and growth factors were measured by Multiplex assay (Bio-Rad, Hercules, CA).. Results Sickle cell disease patients had elevated concentrations of TRACP-5b compared to controls (median values of 4.4 vs. 2.4 U/l, P < 0.0001). Among the patients, TRACP-5b concentrations correlated positively with number of blood transfusions (r = 0.19) and serum concentrations of alkaline phosphatase (r=0.46), endothelin-1 (r=0.39), interleukin-8 (r= 0.38), and interleukin-6 (r=0.25). TRACP-5b correlated negatively with RANTES (r = -0.42) and PDGF (r = -0.31). It did not correlate significantly with serum ferritin (r = -0.03), LDH (r = 0.13) or hemoglobin concentration (r = 0.11). Interestingly, TRACP-5b correlated positively with tricuspid regurgitation velocity, which reflects systolic pulmonary artery pressure (r = 0.30). Conclusion Sickle cell patients have elevated steady-state osteoclast activity as reflected in serum TRACP-5b concentrations. Multiple blood transfusions and inflammation are associated findings. Among patients, higher TRACP-5b concentrations are associated with lower concentrations of RANTES and PDGF-BB, factors that influence function of osteoblasts. Further studies are needed to investigate whether common pathways may be involved in osteoclast activation and pulmonary changes in sickle cell disease. Supported by grants number 2 R25 HL003679-08 and 1 R01 HL079912-02 and 1U54HL090508-01 from NHLBI, by Howard University GCRC grant no 2MOI RR10284-10 from NCRR, NIH, Bethesda, MD, and by the intramural research program of the National Institutes of Health. Disclosures Gordeuk: Biomarin: Research Funding; TRF Pharma: Research Funding; Merck: Research Funding; Novartis: Speakers Bureau.