Literatura científica selecionada sobre o tema "Nanoparticules intelligentes"
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Artigos de revistas sobre o assunto "Nanoparticules intelligentes"
Grisolia, J., S. Lachaize, J.-L. Noullet, A. Biganzoli, C. Rouabhi, R. Tan, F. Guérin et al. "Systèmes intelligents pour l'internet des objets". J3eA 18 (2019): 1020. http://dx.doi.org/10.1051/j3ea/20191020.
Texto completo da fonteVIDIC, Jasmina, e Sandrine AUGER. "Nanoparticules d'oxydes métalliques dans les emballages alimentaires actifs, intelligents et non toxiques". Nanosciences et nanotechnologies, outubro de 2021. http://dx.doi.org/10.51257/a-v1-re291.
Texto completo da fonteTeses / dissertações sobre o assunto "Nanoparticules intelligentes"
Jamal, Al Dine Enaam. "Synthèse et caractérisation des nanoparticules intelligentes". Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0054/document.
Texto completo da fonteOne of the major challenges in nanomedicine is to develop nanoparticulate systems able to serve as efficient diagnostic and/or therapeutic tools against sever diseases, such as infectious or neurodegenerative disorders. To enhance the detection and interpretation contrast agents were developed to increase the signal/noise ratio. Among them, Superparamagnetic Iron Oxide (SPIO) and Quantum Dots (QDs) nanoparticles (NPs) have received a great attention since their development as a liver contrasting agent 20 years ago for the SPIO. Furthermore, their properties, originating from the nanosized dimension and shape, allow different bio-distribution and opportunities beyond the conventional chemical imaging agents. The opportunity to coat those biocompatible NPs by a polymer shell that can ensure a better stability of the materials in the body, enhance their bio-distribution and give them new functionalities. It has appeared then that they are very challenging for medicinal applications. In this work, we have developed new responsive SPIO and QDs based NPs that are able to carry the anticancer drug doxorubicin (DOX) and release it in physiological media and at the physiological temperature. Two families of NPs were synthesized, the first one consist in superparamagnetic Fe3O4 NPs that were functionalized by a biocompatible responsive copolymer based on 2-(2-methoxy) ethyl methacrylate (MEO2MA), oligo (ethylene glycol) methacrylate (OEGMA). The second family consists in the ZnO NPs coated by the same copolymer. For the first time, P(MEO2MAX-OEGMA100-X) was grown by activator regenerated by electron transfer–atom radical polymerization (ARGET-ATRP) from the NPs surfaces by surface-initiated polymerization. The core/shell NPs were fully characterized by the combination of transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and by the physical properties of the nanostructures studied. We demonstrate the efficiency of the ARGET-ATRP process to graft polymers and copolymers at the surface of Fe3O4 and ZnO NPs. The influence of the polymer chain configuration (which leads to the aggregation of the NPs above the collapse temperature of the copolymer (LCST)) was studied. We have demonstrated that the magnetic properties of the core/shell Fe3O4-based nanostructures were only influenced by the amount of the grafted polymer and no influence of the aggregation was evidenced. This simple and fast developed process is efficient for the grafting of various co-polymers from any surfaces and the derived nanostructured materials display the combination of the physical properties of the core and the macromolecular behavior of the shell. The drug release experiments confirmed that DOX was largely released above the co-polymer LCST. Moreover, the cytocompatibility test showed that those developed NPs do not display any cytotoxicity depending on their concentration in physiological media. From the results obtained, it can be concluded that the new nanomaterials developed can be considered for further use as multi-modal cancer therapy tools
Louaguef, Dounia. "Développement de nanoparticules intelligentes type coeur/coquille capables d’encapsuler un médicament pour la thérapie anticancéreuse". Electronic Thesis or Diss., Université de Lorraine, 2023. http://www.theses.fr/2023LORR0130.
Texto completo da fonteCore/shell nanoparticles offer promising applications in nanomedicine due to their multifunctionality. Particular attention has been given to superparamagnetic iron oxide nanoparticles (SPION) core/shell type for the targeted treatment of cancer. The design of the nanoparticles developed in this thesis work is based on the surface-initiated controlled polymerization of monomers of an iron oxide-based core. These new nanomaterials can take advantage of the physical properties of the core and the macromolecular properties of the reactive envelope (a reactive potential has been developed from our process). These smart nanomaterials are then able to transport an anti-cancer drug and deliver it at a controlled temperature in the physiological environment near the tumor site. The final nanomaterials can then combine hyperthermia and chemotherapy. In this work, various sizes of core/shell nanoparticles of iron oxide doped with zinc and manganese (Zn0.4Fe2.6 O4 @ MnFe2O4 ) with a cubic morphology were synthesized by thermal decomposition and functionalized by a heat-sensitive associate based on of (2-(methoxy ethoxy)ethyl methacrylate/ethylene glycol methacrylate (MEO2MA/OEGMA)). To induce cancer targeting and internalization of nanoparticles to cancer cells, the synthesized nanoparticles were functionalized with folic acid, since these cells overexpress receptors that bind folate α3. In this work, we present our recent results on the new nanomaterials we develop and their complete characterizations
Veneziano, Rémi. "Plateforme Nano Bio Intelligente : membrane biomimétique pour la reconstitution d'une cascade calmoduline dépendante". Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20170.
Texto completo da fonteThe main objective of this work is to develop biomimetic membrane models for the reconstitution and study of protein/membrane interaction. Two devices were designed: one operate a nanometric platform composed of phospholipids coated lipid silica/Au nanoparticles, while the other including tethered lipid bilayer reconstitution on a gold surface. The first approach needs the synthesis of nanometer sized gold/silica particles and that are subsequently coated with different phospholipids. The plasmonic properties provided by gold seeds are characterized and they are of utility to follow the interaction between lipids and/or proteins at the surface. Following of these interactions was also realized with electrophoretic mobility analysis. The second biomimetic device involves a membrane assembly on a gold surface. In a first time, a calmodulin layer is bound on the surface. In a second time, a lipid bilayer is assembled above the calmodulin layer by two approaches. In the first approach the lipid bilayer is anchored on the protein layer with chelators lipid and His-Tag bearing by the proteins. While, in the second approach, lipids are bound on the surface and tethered with the use of a cysteamin modified gold surface and functionalized lipids. The anchorage is realized by succinimidyl group and the tethering by polyethylene glycol group wearing by one kind of lipid. A sub-membrane reservoir is created under the lipid bilayer. The biomimetic model formation was followed by plasmonic resonance and fluorescence recovery after photobleaching. After their characterization the tethered model is validated by reconstitution of a particular mechanism: the CyaA toxin from Bordetella pertussis translocation
Mejri, Eya. "Revêtement intelligent à base des silices mésoporeuses fonctionnalisées pour le relargage stimulé d'agents antimicrobiens". Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27248.
Texto completo da fonteBacterial biofilms are composed of single-cell organisms living within a protective matrix formed from natural macromolecules. Unwanted biofilms may have a number of adverse consequences such as reducing heat transfer in heat exchangers, obstruction of porous membranes, surface contamination ships hulls etc. In addition, pathogenic bacteria growing in a biofilm also pose a health hazard when this kind of film is found attached to biomedical implants, catheters, or on contact lenses. The presence of biofilms is difficult to treat because the bacteria are highly resistant to antimicrobial agents. In an attempt to address these problems, we propose to develop an antifouling surface which releases on demand antimicrobial agents in the presence of a biofilm. The proximity and the positioning of the delivery system of bioactive agents under the biofilm will ensure a more efficient use of antimicrobial molecules and minimize side effects of the latter. To do this, we consider the use of layers of colloidal particles of meso-porous silica as delivery agents of antimicrobial agents. Mesoporous silica nanoparticles (NPS Ms) have demonstrated a strong potential for targeted delivery of therapeutic and bioactive agents. Their use in nanomedicine stems from their interesting properties of porosity, the size and the adjustable shape of these particles, their surface chemistry providing a great flexibility for various functionalizations. Moreover, it is possible to load them with various molecules or biomolecules (of various sizes, ranging from ibuprofen to RNA), and exert fine control of the adsorption parameters and release kinetics (desorption). These particles also demonstrate excellent biocompatibility in vitro and in vivo. Keywords : biofilm, mesoporous nanosilica particles, microfluidics, antifouling surfaces.
Trenque, Isabelle. "Synthèse et caractérisation d’oxydes métalliques ZnO au bénéfice de nouvelles stratégies d’élaboration d’absorbeurs IR". Thesis, Bordeaux 1, 2013. http://www.theses.fr/2013BOR14905/document.
Texto completo da fonteThanks to its absorption / reflexion properties limited to the UV and the IR range, n-doped zinc oxide is a promising candidate for the elaboration of transparent and insulating films in smart windows. Nanostructured particles of Ga-doped zinc oxide were elaborated by polyol process. Polyol process was used in order to control the size and the morphology of the particles. Both experimental and theoretical data show that a maximum of IR absorption efficiency is obtained for a doping rate of 2.6 molar percent. Colloidal suspensions with high transmission in the visible range combined with significant absorption of the near infrared range were obtained using two strategies. The first one is the encapsulation of the Ga-doped ZnO particles by a fluoride shells with an intermediate refractive index between ZnO and the dispersion medium. The second one is the optimization of the dispersion state of nano-colloidal suspensions thanks to the adsorption of thioalkanes on the Ga-doped ZnO crystallite surfaces
Trabalhos de conferências sobre o assunto "Nanoparticules intelligentes"
Roy, Ting, Kamel Ben Naceur, Siggi Meissner, Yoshihiko Koyanagi, Mari Takahashi, Russell Ring, Anil Singh, Christian Wilkinson, Hifzi Ardic e Indranil Roy. "Venturi Choke Beans Designed with Abrasion Resistant Nanocomposite Survives Placement Downstream of Wellhead in Aggressive Field Trials and Outperforms Commercial Counterparts". In Offshore Technology Conference. OTC, 2024. http://dx.doi.org/10.4043/35090-ms.
Texto completo da fonte