Literatura científica selecionada sobre o tema "N-Heterocyclic iminium salts"
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Artigos de revistas sobre o assunto "N-Heterocyclic iminium salts"
Kantlehner, Willi, Erwin Haug e Christophe Bauer. "Orthoamide und Iminiumsalze, LXXXI [1]. Orthoamid-Derivate der 1,3-Dimethylparabansäure / Orthoamides and Iminium Salts LXXXI [1]. Orthoamide Derivatives of 1,3-Dimethylparabanic Acid". Zeitschrift für Naturforschung B 67, n.º 9 (1 de setembro de 2012): 907–12. http://dx.doi.org/10.5560/znb.2012-0123.
Texto completo da fonteKantlehner, Willi, e Konstantin Drandarov. "Orthoamides and Iminium Salts LXXVII. Cycloadditions to N,N,N′,N′,N′′,N′′,N′′′,N′′′-Octamethylacetylenedicarboxamidinium Bis(tetrafluoroborate): A New Synthetic Method for the Preparation of Heterocyclic Dicarboxamidinium Salts". Synthesis 44, n.º 15 (26 de junho de 2012): 2408–12. http://dx.doi.org/10.1055/s-0031-1290410.
Texto completo da fonteKantlehner, Willi, Markus Vettel e Bernhard Eppinger. "Orthoamide und Iminiumsalze, LXXVI [1]. Ein weiterer Beitrag zur Chemie der Trialkoxyacetonitrile/ Orthoamides and Iminium Salts LXXVI [1]. A Further Contribution to the Chemistry of Trialkoxyacetonitriles". Zeitschrift für Naturforschung B 67, n.º 4 (1 de abril de 2012): 373–88. http://dx.doi.org/10.1515/znb-2012-0412.
Texto completo da fonteT. Gupton, John, Scott A. Petrich, Fred A. Hicks, Doug R. Wilkinson, Marian Vargas, Kirsten N. Hosein e James A. Sikorski. "The Preparation of Heterocyclic Appended Vinylogous Iminium Salts and Their Application to the Regioselective Preparation of Biheterocyclic Systems". HETEROCYCLES 47, n.º 2 (1998): 689. http://dx.doi.org/10.3987/com-97-s(n)21.
Texto completo da fonteTeses / dissertações sobre o assunto "N-Heterocyclic iminium salts"
Casanova, Marion. "Conception et évaluation de vecteurs polymériques d'iminium N-hétérocyclique à activité antiplasmodiale". Electronic Thesis or Diss., Aix-Marseille, 2023. http://theses.univ-amu.fr.lama.univ-amu.fr/230324_CASANOVA_795kpzkf736jdsb801go615hzgclu_TH.pdf.
Texto completo da fonteDrug delivery has emphasised real pharmacological and pharmacokinetic advancements. Nevertheless, few in-depth and original studies have been conducted on antimalarial vectors. Only approved drugs, for which the parasites have developed resistance mechanisms, have been used in vectorization. The conditions and costs of preparation of these nanoformulations constitute a major barrier to their future production. This project aimed at developing nanovectors for the delivery of new antiparasitic drugs, while relying on a both accessible and innovative "click" synthesis strategy. First, the antimalarial efficiency of new N-heterocyclic iminium salts was evaluated on Plasmodium falciparum, responsible for malaria. Bis-aminopyridinium salts proved to be the most promising candidates with sub-micromolar antiplasmodial activities and an original mechanism of action, probably related to their strong redox properties. Secondly, the vectorization of these bis-aminopyridinium drug candidates was undertaken through preparation of polymer-drug conjugate nanovectors. The latter were obtained via a simple strategy, consisting in the use of the bis-aminopyridinium salt as polymerization initiator of its own nanovector. The SAR study underlined the need for a first acrylate block and spherical arrangements on the activity. Hence, a soluble, biodegradable, and stealth triblock system with sizes lower than 100 nm and enabling the delivery of 5 mol% of drug, showed effective antiplasmodial activity, without any cytotoxic effect