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Bibliografias temáticas / Mutation rate evolution

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Artigos de revistas

Literatura científica selecionada sobre o tema "Mutation rate evolution"

Autor: Grafiati

Publicado: 22 de junho de 2024

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Artigos de revistas sobre o assunto "Mutation rate evolution"

1

Trindade, Sandra, Lilia Perfeito, and Isabel Gordo. "Rate and effects of spontaneous mutations that affect fitness in mutator Escherichia coli." Philosophical Transactions of the Royal Society B: Biological Sciences 365, no. 1544 (2010): 1177–86. http://dx.doi.org/10.1098/rstb.2009.0287.

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Knowledge of the mutational parameters that affect the evolution of organisms is of key importance in understanding the evolution of several characteristics of many natural populations, including recombination and mutation rates. In this study, we estimated the rate and mean effect of spontaneous mutations that affect fitness in a mutator strain of Escherichia coli and review some of the estimation methods associated with mutation accumulation (MA) experiments. We performed an MA experiment where we followed the evolution of 50 independent mutator lines that were subjected to repeated bottlene

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2

Sherer, Nicholas A., and Thomas E. Kuhlman. "Escherichia coli with a Tunable Point Mutation Rate for Evolution Experiments." G3: Genes|Genomes|Genetics 10, no. 8 (2020): 2671–81. http://dx.doi.org/10.1534/g3.120.401124.

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The mutation rate and mutations’ effects on fitness are crucial to evolution. Mutation rates are under selection due to linkage between mutation rate modifiers and mutations’ effects on fitness. The linkage between a higher mutation rate and more beneficial mutations selects for higher mutation rates, while the linkage between a higher mutation rate and more deleterious mutations selects for lower mutation rates. The net direction of selection on mutations rates depends on the fitness landscape, and a great deal of work has elucidated the fitness landscapes of mutations. However, tests of the

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3

Stephan, Wolfgang. "The Rate of Compensatory Evolution." Genetics 144, no. 1 (1996): 419–26. http://dx.doi.org/10.1093/genetics/144.1.419.

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Abstract A two-locus model is presented to analyze the evolution of compensatory mutations occurring in stems of RNA secondary structures. Single mutations are assumed to be deleterious but harmless (neutral) in appropriate combinations. In proceeding under mutation pressure, natural selection and genetic drift from one fitness peak to another one, a population must therefore pass through a valley of intermediate deleterious states of individual fitness. The expected time for this transition is calculated using diffusion theory. The rate of compensatory evolution, kc, is then defined as the in

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4

Sniegowski, Paul. "Evolution: Setting the mutation rate." Current Biology 7, no. 8 (1997): R487—R488. http://dx.doi.org/10.1016/s0960-9822(06)00244-2.

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5

Lynch, Michael. "Evolution of the mutation rate." Trends in Genetics 26, no. 8 (2010): 345–52. http://dx.doi.org/10.1016/j.tig.2010.05.003.

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6

Schoen, Daniel J., and Stewart T. Schultz. "Somatic Mutation and Evolution in Plants." Annual Review of Ecology, Evolution, and Systematics 50, no. 1 (2019): 49–73. http://dx.doi.org/10.1146/annurev-ecolsys-110218-024955.

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Somatic mutations are common in plants, and they may accumulate and be passed on to gametes. The determinants of somatic mutation accumulation include the intraorganismal selective effect of mutations, the number of cell divisions that separate the zygote from the formation of gametes, and shoot apical meristem structure and branching. Somatic mutations can promote the evolution of diploidy, polyploidy, sexual recombination, outcrossing, clonality, and separate sexes, and they may contribute genetic variability in many other traits. The amplification of beneficial mutations via intraorganismal

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7

Krasovec, Marc, Rosalind E. M. Rickaby, and Dmitry A. Filatov. "Evolution of Mutation Rate in Astronomically Large Phytoplankton Populations." Genome Biology and Evolution 12, no. 7 (2020): 1051–59. http://dx.doi.org/10.1093/gbe/evaa131.

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Abstract Genetic diversity is expected to be proportional to population size, yet, there is a well-known, but unexplained lack of genetic diversity in large populations—the “Lewontin’s paradox.” Larger populations are expected to evolve lower mutation rates, which may help to explain this paradox. Here, we test this conjecture by measuring the spontaneous mutation rate in a ubiquitous unicellular marine phytoplankton species Emiliania huxleyi (Haptophyta) that has modest genetic diversity despite an astronomically large population size. Genome sequencing of E. huxleyi mutation accumulation lin

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8

Edlund, Jeffrey A., and Christoph Adami. "Evolution of Robustness in Digital Organisms." Artificial Life 10, no. 2 (2004): 167–79. http://dx.doi.org/10.1162/106454604773563595.

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We study the evolution of robustness in digital organisms adapting to a high mutation rate. As genomes adjust to the harsh mutational environment, the mean effect of single mutations decreases, up until the point where a sizable fraction (up to 30% in many cases) of the mutations are neutral. We correlate the changes in robustness along the line of descent to changes in directional epistasis, and find that increased robustness is achieved by moving from antagonistic epistasis between mutations towards codes where mutations are, on average, independent. We interpret this recoding as a breakup o

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9

Komp Lindgren, Patricia, Åsa Karlsson, and Diarmaid Hughes. "Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary Tract Infections." Antimicrobial Agents and Chemotherapy 47, no. 10 (2003): 3222–32. http://dx.doi.org/10.1128/aac.47.10.3222-3232.2003.

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ABSTRACT Escherichia coli strains from patients with uncomplicated urinary tract infections were examined by DNA sequencing for fluoroquinolone resistance-associated mutations in six genes: gyrA, gyrB, parC, parE, marOR, and acrR. The 54 strains analyzed had a susceptibility range distributed across 15 dilutions of the fluoroquinolone MICs. There was a correlation between the fluoroquinolone MIC and the number of resistance mutations that a strain carried, with resistant strains having mutations in two to five of these genes. Most resistant strains carried two mutations in gyrA and one mutatio

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10

Gerrish, Philip J., Alexandre Colato, and Paul D. Sniegowski. "Genomic mutation rates that neutralize adaptive evolution and natural selection." Journal of The Royal Society Interface 10, no. 85 (2013): 20130329. http://dx.doi.org/10.1098/rsif.2013.0329.

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When mutation rates are low, natural selection remains effective, and increasing the mutation rate can give rise to an increase in adaptation rate. When mutation rates are high to begin with, however, increasing the mutation rate may have a detrimental effect because of the overwhelming presence of deleterious mutations. Indeed, if mutation rates are high enough: (i) adaptive evolution may be neutralized, resulting in a zero (or negative) adaptation rate despite the continued availability of adaptive and/or compensatory mutations, or (ii) natural selection may be neutralized, because the fitne

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