Bibliografias temáticas / Mutagens

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Literatura científica selecionada sobre o tema "Mutagens"

Autor: Grafiati
Publicado: 4 de junho de 2021
Última modificação: 27 de julho de 2024

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Artigos de revistas sobre o assunto "Mutagens"

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Otsubo, Yuki, Shoji Matsumura, Naohiro Ikeda e Osamu Morita. "Hawk-Seq™ differentiates between various mutations in Salmonella typhimurium TA100 strain caused by exposure to Ames test-positive mutagens". Mutagenesis 36, n.º 3 (16 de fevereiro de 2021): 245–54. http://dx.doi.org/10.1093/mutage/geab006.

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Abstract A precise understanding of differences in genomic mutations according to the mutagenic mechanisms detected in mutagenicity data is required to evaluate the carcinogenicity of environmental mutagens. Recently, we developed a highly accurate genome sequencing method, ‘Hawk-Seq™’, that enables the detection of mutagen-induced genome-wide mutations. However, its applicability to detect various mutagens and identify differences in mutational profiles is not well understood. Thus, we evaluated DNA samples from Salmonella typhimurium TA100 exposed to 11 mutagens, including alkylating agents, aldehydes, an aromatic nitro compound, epoxides, aromatic amines and polycyclic aromatic hydrocarbons (PAHs). We extensively analysed mutagen-induced mutational profiles and studied their association with the mechanisms of mutagens. Hawk-Seq™ sensitively detected mutations induced by all 11 mutagens, including one that increased the number of revertants by approximately 2-fold in the Ames test. Although the sensitivity for less water-soluble mutagens was relatively low, we increased the sensitivity to obtain high-resolution spectra by modifying the exposure protocol. Moreover, two epoxides indicated similar 6- or 96-dimensional mutational patterns; likewise, three SN1-type alkylating agents indicated similar mutational patterns, suggesting that the mutational patterns are compound category specific. Meanwhile, an SN2 type alkylating agent exhibited unique mutational patterns compared to those of the SN1 type alkylating agents. Although the mutational patterns induced by aldehydes, the aromatic nitro compound, aromatic amines and PAHs did not differ substantially from each other, the maximum total base substitution frequencies (MTSFs) were similar among mutagens in the same structural groups. Furthermore, the MTSF was found to be associated with the carcinogenic potency of some direct-acting mutagens. These results indicate that our method can generate high-resolution mutational profiles to identify characteristic features of each mutagen. The detailed mutational data obtained by Hawk-Seq™ can provide useful information regarding mutagenic mechanisms and help identify its association with the carcinogenicity of mutagens without requiring carcinogenicity data.
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Ang, Jocelyn, Lisa Yun Song, Sara D'Souza, Irene L. Hong, Rohan Luhar, Madeline Yung e Jeffrey H. Miller. "Mutagen Synergy: Hypermutability Generated by Specific Pairs of Base Analogs". Journal of Bacteriology 198, n.º 20 (25 de julho de 2016): 2776–83. http://dx.doi.org/10.1128/jb.00391-16.

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ABSTRACTWe tested pairwise combinations of classical base analog mutagens inEscherichia colito study possible mutagen synergies. We examined the cytidine analogs zebularine (ZEB) and 5-azacytidine (5AZ), the adenine analog 2-aminopurine (2AP), and the uridine/thymidine analog 5-bromodeoxyuridine (5BrdU). We detected a striking synergy with the 2AP plus ZEB combination, resulting in hypermutability, a 35-fold increase in mutation frequency (to 53,000 × 10−8) in therpoBgene over that with either mutagen alone. A weak synergy was also detected with 2AP plus 5AZ and with 5BrdU plus ZEB. The pairing of 2AP and 5BrdU resulted in suppression, lowering the mutation frequency of 5BrdU alone by 6.5-fold. Sequencing the mutations from the 2AP plus ZEB combination showed the predominance of two new hot spots for A·T→G·C transitions that are not well represented in either single mutagen spectrum, and one of which is not found even in the spectrum of a mismatch repair-deficient strain. The strong synergy between 2AP and ZEB could be explained by changes in the dinucleoside triphosphate (dNTP) pools.IMPORTANCEAlthough mutagens have been widely studied, the mutagenic effects of combinations of mutagens have not been fully researched. Here, we show that certain pairwise combinations of base analog mutagens display synergy or suppression. In particular, the combination of 2-aminopurine and zebularine, analogs of adenine and cytidine, respectively, shows a 35-fold increased mutation frequency compared with that of either mutagen alone. Understanding the mechanism of synergy can lead to increased understanding of mutagenic processes. As combinations of base analogs are used in certain chemotherapy regimens, including those involving ZEB and 5AZ, these results indicate that testing the mutagenicity of all drug combinations is prudent.
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Nazarenko, M. M. "The influence of radio-mimetic chemical mutagen on the chromosomal complex of winter wheat cells". Regulatory Mechanisms in Biosystems 8, n.º 2 (7 de maio de 2017): 283–86. http://dx.doi.org/10.15421/021744.

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In this article we report the results of our investigation of cytogenetic parameters of changes in the chromosomal complex of new Ukrainian winter wheat varieties and some relationships between values of cytological indexes and different concentrations of DAB (1,4-bis-diazoacetyl butane). Analysis of chromosomal aberrations following mutagenic action of any kind of mutagen by the anaphase method is one of the most widely investigated and most precise methods which can be used to determine the fact of mutagenic action on plants and identify the nature of the mutagen. We combined in our investigation sensitivity of genotype to mutagen using cytological analysis of mutagen treated wheat populations with the corresponding different varieties by breeding methods to reveal their connections and differences, specific sensitivity to mutagenic action on the cell level. Dry seeds of 7 varieties and 1 line of winter wheat were subjected to DAB in 0.1% and 0.2% concentration, which is standard practice for mutation breeding of winter wheat. We investigated rates and spectra of chromosomal aberrations in the cells of the primary root tips of winter wheat during mitosis. The coefficient of correlations between the rate of chromosomal aberrations and the concentration of DAB was at the level 0.6%. Fragments/bridges ratio is a clear and sufficient index for determining the nature of the mutagen agent. We distinguished the following types of chromosomal rearrangements: chromatid and chromosome bridges, single and double fragments, micronuclei, and lagging chromosomes. Investigation of DAB action confirmed the reliability of the fragments-bridges ratio (prevalence of fragments over bridges for chemical mutagens and vice versa for gamma-rays) for identification of the nature of the mutagen. Complicated (or combined) aberrations, micronucleus, lagging chromosomes were not observed for some varieties under DAB action. Genotypes selected after action of chemical mutagens are less sensitive to recurrent mutagenesis with chemical mutagens.
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Moreno, Débora Antunes Neto, Jaqueline de Cássia Proença-Assunção, Anna Paula Farias-de-França, Gabriel Ferreira Dos Santos e Yoko Oshima-Franco. "The antimutagenic potential of Vanillin and Betulin based on the antimutagenicity of Resveratrol". CONTRIBUCIONES A LAS CIENCIAS SOCIALES 16, n.º 8 (30 de agosto de 2023): 13224–43. http://dx.doi.org/10.55905/revconv.16n.8-255.

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Due to daily exposure to several compounds with mutagenic potential, it is extremely important to find antimutagenic agents, as here proposed to vanillin and betulin found in Dipteryx alata plant, evaluated by the Salmonella/microsome assay and resveratrol as reference. The antimutagenicity test employs mutagens that are incubated with a test substance to assess the inhibitory ability of the mutagenicity, interpreted as absent, moderate, or strong when the percentage of inhibition is lower than 25%; between 25 – 40% or greater than 40%, respectively. The assays were carried out in the absence (-S9) and in the presence (+S9) of metabolic activation using conventional mutagens for TA97a, TA98, TA100 and TA102. Resveratrol strongly inhibited all mutagens from -S9 and +S9. Vanillin moderately inhibited the mutagen of TA97a (-S9), and strongly for all strains in +S9. Betulin moderately inhibited mutagen from TA97a (-S9), strongly for TA100 and TA102 (-S9), and all strains in +S9. The obtained results were all concentration dependent. Concluding, this is an unprecedented study in which all mutagens commonly used in the Salmonella/microsome assay were tested to attribute antimutagenic abilities – from moderate to strong - to vanillin and betulin face to resveratrol, a strong antimutagen.
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Rajkumari, Jinu Devi. "Efficiency and effectiveness of physical and chemical mutagens in Trigonella foenum graecum L". NBU Journal of Plant Sciences 6, n.º 1 (2012): 87–88. http://dx.doi.org/10.55734/nbujps.2012.v06i01.013.

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Trigonella foemum graecum L was utilized to study the Chlorophyll mutations, mutagenic efficiency and effectiveness by physical mutagen gamma rays and chemical mutagen EMS. The frequency of chlorophyll mutation in M1 & M2 generation were more in gamma treated plants but the mutation spectra and mutagenic efficiency of EMS was higher than gamma. The most efficient mutagens were 0. 02% EMS, 0.06% EMS and 3KR gamma radiation to induce mutation in T. foenum graceum L.
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Mullainathan, L., e S. Umavathi. "Induced Mutagenesis in Cicer arietinum". International Letters of Natural Sciences 12 (março de 2014): 1–4. http://dx.doi.org/10.18052/www.scipress.com/ilns.12.1.

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The traditional varieties of chick pea have low potentiality and restricted variability with respect to economic characters. Broadening the genetic base for crop improvement can be quickly achieved through induced mutagenesis. The present study was undertaken in order to comparing the effectiveness and efficiency of mutagens on Cicer arietinum. In this regard, Co – 4 variety of chick pea was subjected to different dose/concentration of Gamma rays (20, 30, 40, 50 and 60 kR) and Ethyl Methane Sulphonate (10, 20, 30, 40 and 50 mM) for inducing mutation. Mutagenic effectiveness and efficiency was calculated based on biological damage in M1 and chlorophyll mutations in M2. The results indicated that, mutagenic effectiveness increased with the increase in dose/concentration of mutagen. Intermediate treatments in general were found more efficient in causing less biological damage and inducing maximum amount of mutations. It shows that the chemical mutagens are more effective and efficient than physical mutagen for inducing mutation in Chick pea
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Mullainathan, L., e S. Umavathi. "Induced Mutagenesis in <i>Cicer arietinum</i>". International Letters of Natural Sciences 12 (14 de março de 2014): 1–4. http://dx.doi.org/10.56431/p-cp3s6r.

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The traditional varieties of chick pea have low potentiality and restricted variability with respect to economic characters. Broadening the genetic base for crop improvement can be quickly achieved through induced mutagenesis. The present study was undertaken in order to comparing the effectiveness and efficiency of mutagens on Cicer arietinum. In this regard, Co – 4 variety of chick pea was subjected to different dose/concentration of Gamma rays (20, 30, 40, 50 and 60 kR) and Ethyl Methane Sulphonate (10, 20, 30, 40 and 50 mM) for inducing mutation. Mutagenic effectiveness and efficiency was calculated based on biological damage in M1 and chlorophyll mutations in M2. The results indicated that, mutagenic effectiveness increased with the increase in dose/concentration of mutagen. Intermediate treatments in general were found more efficient in causing less biological damage and inducing maximum amount of mutations. It shows that the chemical mutagens are more effective and efficient than physical mutagen for inducing mutation in Chick pea
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Langová, M., Z. Polívková, P. Šmerák, J. Bártová e I. Bárta. "Antimutagenic effect of resveratrol". Czech Journal of Food Sciences 23, No. 5 (15 de novembro de 2011): 202–8. http://dx.doi.org/10.17221/3392-cjfs.

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Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutagenic activity of three mutagens, i.e. aflatoxin B<sub>1</sub> (AFB<sub>1</sub>), 2-amino-3-methylimidazo[4,5-f]qui-noline (IQ) and N-nitroso-N-methylurea (MNU) using the Ames and the micronucleus tests. In the Ames test, we proved a significant antimutagenic activity only against the indirect mutagens AFB<sub>1</sub> and IQ, not against the direct mutagen MNU. A significant decrease of mutagenicity of all three mutagens was detected by the micronucleus test. &nbsp;
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Nagarajan*, Prabhu, Vigneshwari Ramakrishnan Sundaramoorthy e Joseph Pushpa Innocent Danialas. "Antimutagenic effects of compounds obtained from Eclipta alba linn. against strains of Salmonella typhimurium". International Journal of Bioassays 1, n.º 10 (16 de outubro de 2012): 102. http://dx.doi.org/10.21746/ijbio.2012.10.009.

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In this experimental study, antimutagenic activity of compounds obtained from Eclipta alba Linn was screened by using Ames assay for detecting direct mutagenic activity and those requiring the metabolic activation. The crude compound extracted from Eclipta alba was considered as antimutagen and analyzed in this experiment. Two strains of Salmonella typhimurium, TA163 and TA96 were used to analyze the test. These two strains are confirmed as histidine requiring mutant strains. When the mutagen is added to the culture, the strain is mutated back, thereby loosing the histidine dependence for its growth. By this study, the crude compound of Eclipta alba prevents the strain to be mutated back to the non dependence for the genotyping of the Salmonella strains were performed by histidine requirement, rfa mutation analysis, UVrB mutation, R-factor analysis toxicity tests and antimutagenicity assay. The antimutagens obtained from the plant extract were determined for antimutagenic activity against direct acting mutagens and mutagen needing activation. For direct acting mutagens, NPD (N- nitro-o-phenyl diamine), MNNG (N- methyl-N-nitro-N-nitro soguanidine) and NaNa3 (sodium azide) with 1mg of the plant extract gives 98%, 95.2% and 90.7% inhibition the reverted colonies were observed whereas the mutagen needing activation 2-AAf (2-acetyl aminofluorine) gives 96.6% inhibition was observed. These above results indicated that the extract could inhibit the mutagenicity induced by direct acting mutagens as well as mutagens needing activation. Thus the extracts isolated from the test plant have possibility of antimutagenic activity of compound and further biochemicals extracted from the test plant will be analyzed.
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Šmerák, P., H. Šestáková, Z. Polívková, I. Bárta, B. Turek, J. Bártová, M. Langová e M. Anděl. "Antimutagenic effect of ellagic acid and its effect on the immune response in mice". Czech Journal of Food Sciences 20, No. 5 (19 de novembro de 2011): 181–91. http://dx.doi.org/10.17221/3530-cjfs.

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Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of ellagic acid on the genotoxicity of three mutagens: amino-methylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). Ellagic acid is a naturally occurring phenolic compound which is found in a variety of soft fruits and vegetables. The effect of this compound on the immunosuppressive activity of mutagens was followed in vivo by the chemiluminescence test. In the Ames assay, ellagic acid at concentrations of 300 and 30 &mu;g/plate demonstrably inhibits the mutagenic activity of two indirect mutagens: IQ and AFB1. The concentration of 300 &mu;g/plate had the strongest effect on mutagenicity of all concentrations of IQ in strain TA98 of Salmonella typhimurium, whereas in strain TA100 concentration of 30 &mu;g per dish of ellagic acid was more effective than 300 &mu;g per plate. Also in combination with different concentrations of AFB1, ellagic acid proved to be a strong antimutagen. In this case the lower of the two effective concentrations &ndash; 30 &mu;g/plate &ndash; had a much greater antimutagenic effect on both strains tested than 300 &mu;g/plate. In combination with the direct mutagen MNU, ellagic acid did not show any marked antimutagenic effect at most of the concentrations tested in strain TA100. Only the highest concentrations of ellagic acid reduced the mutagenic effect of MNU weakly and only in combination with two lower concentrations of MNU. In the micronucleus test, three-day oral application of ellagic acid prior to the applicaton of AFB1, IQ, or MNU, respectively, markedly reduced the numbers of micronuclei induced by these three mutagens in polychromatophilic erythrocytes of mice. Chemiluminescence test with mouse granulocytes proved that ellagic acid not only prevents the inhibitory effects of mutagens on free oxygen radicals and hydrogen peroxide production, but that this production is stimulated by ellagic acid in combination with mutagens even to a greater extent than by ellagic acid alone. From these results we can deduce that ellagic acid repairs strong immunosuppressive effects of all mutagens applied. &nbsp;
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Teses / dissertações sobre o assunto "Mutagens"

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Papaparaskeva-Petrides, Christina. "Mutagens in edible mushrooms". Thesis, University of Surrey, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314464.

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Schuisky, Peter. "Synthesis of metal complexes and potential food mutagens /". Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1998. http://epsilon.slu.se/avh/1998/91-576-5517-0.gif.

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Ayrton, Andrew David. "Food mutagens : factors that modulate their metabolic activation". Thesis, University of Surrey, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328576.

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Kanungnit, Pupatwibul Brockman Herman E. "Effects of six dietary antimutgen[sic] on the mutagenicity of five dietary mutagens in Salmonella typhimurium strains TA98 and SV50". Normal, Ill. Illinois State University, 1992. http://wwwlib.umi.com/cr/ilstu/fullcit?p9234467.

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Thesis (Ph. D.)--Illinois State University, 1992.
Title from title page screen, viewed January 30, 2006. Dissertation Committee: Herman E. Brockman (chair), Alan J. Katz, Brian J. Wilkinson, Lynne A. Lucher, Radheshaym Jayaswal. Includes bibliographical references (leaves 115-123) and abstract. Also available in print.
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Tippins, T. A. "Various factors which affect the response of yeast cells to environmental mutagens". Thesis, Swansea University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639246.

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This project investigates the factors which may affect the response of yeast cells to potential mutagens and thus to optimise their response. The problem was approached from four main angles as follows: i) permeability - rendering the cells more permeable either by pre-treatment with selected chemicals or by selecting clones with cell wall defects; ii) repair capacity - preventing adequate repair of damaged DNA either by post-treatment with repair inhibitors or by using strains with defective repair genes; iii) genetic background - looking at reversion in the same gene but in a different genetic background or different genes in the same background; iv) treatment conditions - treating cells in buffer or broth, with or without exogenous activation, at 28 C or 37 C. The general conclusions which may be drawn from these studies are: a) most chemical mutagens are able to enter the yeast cells in sufficient quantities to cause damage to the DNA without pre-treating the cells to increase their permeability; b) the repair capacity of a cell is a very important factor in its response to a mutagen and if this capacity is greatly impaired, then the chances of survival of the cell after treatment with a mutagen are greatly reduced; c) the genetic background of a cell and the marker under consideration can affect the response of the cell to a mutagen; d) the conditions under which yeast cells are exposed to mutagens affect both the response of the yeast cells and the effectiveness of the mutagen itself. As for optimising the response of the yeast cells to mutagens this can only be done by gathering together all the information already known about the compound under study, and any related compounds, and analysing this data to discover what treatment conditions should be used and possibly what test.
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Howes, A. J. "In vitro and in vivo studies of mutagens found in cooked food". Thesis, University of Surrey, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378734.

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Manna, David. "Mutational analysis of the central channel in the Simian virus 40 large T antigen helicase". Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 2.82 Mb., 110 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1435876.

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Sedijani, Prapti, of Western Sydney Hawkesbury University, of Science Technology and Agriculture Faculty e School of Horticulture. "The use of mutagenic agents to increase the protein content and improve the amino acid composition of sweet potato (Ipomea batatas Lam.)". THESIS_FSTS_HOR_Sedijani_P.xml, 1997. http://handle.uws.edu.au:8081/1959.7/647.

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The sweet potato has become a major international crop and it is also the main staple food for many people in the developing world. This crop is desirable as it is high yielding, easy to grow and has a low cost of production. However, the tubers have a low protein content and a low concentration of amino acids, particularly the aspartate amino acid. This has contributed to malnutrition in some areas. To help overcome this problem this study had the aim of producing lines of sweet potato with increased nutritional values. Two varieties, Beauregard and LO322, were selected for study as they have a good flavour and a high beta-carotene content. The conditions for the tissue culture of these varieties were determined by altering the mineral and hormonal composition of the culture medium. Increases in nutritional composition were induced by treating calli with mutagenic agents which included : colchicine, ethylmethanesulphonate, UV radiation and two levels of gamma radiation. Putative mutants with reduced feedback inhibition in the pathways which lead to the synthesis of the aspartate amino acids were selected by placing calli on media containing increasing concentrations of lysine and threonine. During the final stage of the selection process, calli were placed on a medium without the addition of selection agents. The results from the tissue culture study suggest that media, 2, 4-D and explant size affect callus growth. MSMA medium (a modified Murashige and Skoog medium) was the most suitable for growing the callus of Beauregard whilst modified White's medium (MW) was better for the growth of LO322 calli. The most prolific callus growth was exhibited by explants of the cultivar Beauregard when placed on MSMA medium. This combination was used to determine the potential of mutagenic treatments to improve the nutritional qualities of the sweet potato. Results from treatments with mutagenic agents showed that all mutagens used had the capability of increasing the soluble protein content of callus. These treatments also had the capacity to increase the concentration of aspartate and other amino acids. Of the mutagens trialed, a treatment with 500 rad gamma radiation appears to be the most suitable for increasing protein and amino acid concentrations. Therefore, once the conditions for regeneration of shoots from calli have been determined this study suggests that it should be possible to produce lines of sweet potato with increased nutritional values using this agent
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Cabrera, Guillermo Lopez Brockman Herman E. "Effect of five dietary antimutagens on the genotoxicity of six mutagens using three different short-term tests". Normal, Ill. Illinois State University, 1993. http://wwwlib.umi.com/cr/ilstu/fullcit?p9416862.

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Thesis (Ph. D.)--Illinois State University, 1993.
Title from title page screen, viewed March 7, 2006. Dissertation Committee: Herman E. Brockman (chair), Alan J. Katz, Brian J. Wilkinson, David F. Weber, Radheshyam K. Jayaswal. Includes bibliographical references (leaves 162-177) and abstract. Also available in print.
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Donnelly, Eilish Teresa. "An investigation of DNA repair in wild-type, amino acid auxotrophs and UV-sensitive mutants of Aspergillus nidulans". Thesis, University of Ulster, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243733.

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Livros sobre o assunto "Mutagens"

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International Chemical Congress of Pacific Basin Societies (1984 Honolulu, Hawaii). Dietary mutagens. Research Triangle Park, N.C: National Institute of Environmental Health Sciences, 1986.

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Kesari, Kavindra Kumar, ed. Networking of Mutagens in Environmental Toxicology. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-96511-6.

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1934-, Hayatsu Hikoya, ed. Mutagens in food: Detection and prevention. Boca Raton: CRC Press, 1991.

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D, Bloom Arthur, Spatz Lawrence, Paul Natalie W, March of Dimes Birth Defects Foundation. e Environmental Health Institute (Pittsfield, Mass.), eds. Genetic susceptibility to environmental mutagens and carcinogens. White Plains, N.Y: March of Dimes Birth Defects Foundation, 1989.

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Wright, Cherylyn W. Fractionation of mutagens from municipal sludge and wastewater. Research Triangle Park, NC: U.S. Environmental Protection Agency, Health Effects Research Laboratory, 1989.

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Raat, Willem Karel de. Mutagens and polycyclic aromatic hydrocarbons in ambient airborne particles. [Leiden?: s.n., 1991.

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M, Carpanini F., e European Centre for Ecotoxicology and Toxicology of Chemicals., eds. Aneuploidy. Brussels: ECETOC, 1997.

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Carlson, Robert M. The isolation and identification of electrophilic mutagens produced during cholorine disinfection. Research Triangle Park, NC: U.S. Environmental Protection Agency, Health Effects Research Laboratory, 1989.

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1946-, Arutyunyan R. M., ed. Anticlastogens in mammalian and human cells. Berlin: Springer-Verlag, 1991.

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K, Elespuru Rosalie, Albertini Richard J e Environmental Mutagen Society, eds. Environmental Mutagens Society 20th anniversary issue: Perspectives on genetic toxicology. New York: Alan R. Liss, 1989.

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Capítulos de livros sobre o assunto "Mutagens"

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Alston, Frances, e Onwuka Okorie. "Mutagens". In Occupational Exposures, 133–42. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003220114-9.

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Datta, Subodh Kumar. "Mutagens". In Induced Mutation Breeding, 85–90. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9489-0_4.

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de Boer, Peter. "Chromosomal Causes for Fertility Reduction in Mammals". In Chemical Mutagens, 427–67. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2147-7_11.

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Mortelmans, Kristien E., e Linda Dousman. "Mutagenesis and Plasmids". In Chemical Mutagens, 469–507. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2147-7_12.

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Siciliano, Michael J., Raymond L. Stallings, Ronald M. Humphrey e Gerald M. Adair. "Mutation in Somatic Cells as Determined by Electrophoretic Analysis of Mutagen-Exposed Chinese Hamster Ovary Cells". In Chemical Mutagens, 509–31. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2147-7_13.

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Jaenisch, Rudolf, e Philippe Soriano. "Retroviruses as Insertional Mutagens". In New Frontiers in the Study of Gene Functions, 121–29. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1845-3_10.

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Jägerstad, Margaretha, e Kerstin Skog. "Formation of Meat Mutagens". In Advances in Experimental Medicine and Biology, 83–105. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-2626-5_7.

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Shankel, D. M., S. Kuo, C. Haines e L. A. Mitscher. "Extracellular Interception of Mutagens". In Antimutagenesis and Anticarcinogenesis Mechanisms III, 65–74. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2984-2_5.

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Ghanim, Abdelbagi M. A. "Physical Mutagenesis in Cereal Crops". In Mutation Breeding and Efficiency Enhancing Technologies for Resistance to Striga in Cereals, 13–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-68181-7_2.

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AbstractThe use of physical mutagens to induce heritable genetic variation in crop plants dates back to the beginning of the twentieth century. While X-rays were the first to be used for mutation induction in plants, gamma-rays have been the most widely used physical mutagen. Currently gamma induced mutations represents 60% of the registered mutant varieties in the Mutant Variety Database of the Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture. Beside gamma and X-rays, other physical mutagens include neutrons, beta particles, alpha particles, protons and ion beam. This chapter introduces the technique of physical mutagenesis with emphasis on gamma-ray and X-ray irradiation of seeds in cereals in the context of inducing genetic variation for resistance to the parasitic weed, Striga. Easy to follow step-by-step protocols are explained including sample preparation, treatment application and post-treatment handling of irradiated seeds. Data collection and graphic illustration are presented to estimate the optimum dose for bulk treatment to determine the radio-sensitivity of cereal crops. The last section briefly explains the development and handling of mutant populations by way of introduction to the rest of this book on mutation breeding in cereals for resistance to Striga.
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Preston, Bradley D., e Rupa Doshi. "Molecular Targets of Chemical Mutagens". In Advances in Experimental Medicine and Biology, 193–209. Boston, MA: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4684-5877-0_20.

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Trabalhos de conferências sobre o assunto "Mutagens"

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Osada, K., S. Okazaki, S. Kimura, K. Hishinuma, S. Mashiko, M. Kobayashi e H. Inaba. "Optical detection of mutagenic substances using ultraweak chemiluminescence from primary culture of rat hepatocytes". In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1987. http://dx.doi.org/10.1364/oam.1987.thpo45.

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Very weak light emission observed in the Ames test system suggests that such chemiluminescence can be used for the detection and monitoring of mutagenic substances. To explore a new potentially practicable method of detection, we measured and examined ultraweak chemiluminescence as the response of a primary culture of rat hepatocytes to specific mutagenic and nonmutagenic substances employing a highly sensitive photon counting system that has been developed recently by our group. Hepatocytes were collected from rats (Wistar, male, 6 weeks of age) using the collagenase perfusion method and cultured for 96 h. Mutagens were added to the cells, and chemiluminescence intensity was analyzed. We found that benzo(a)pyrene, recognized as a strong mutagen, exhibited significant chemiluminescence from the hepatocytes in a dose-dependent manner for over 30 min. Substances showing no mutagenic activity, such as pyrene or triphenylene, exhibited no significant emission in the hepatocytes.
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Abu-Bakar, A’edah, Masao Fukumura e Salmaan Hussain Inayat Hussain. "Workplace Management of Carcinogens, Mutagens and Reproductive Toxicants". In SPE Symposium: Asia Pacific Health, Safety, Security, Environment and Social Responsibility. Society of Petroleum Engineers, 2019. http://dx.doi.org/10.2118/195403-ms.

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Nemtinov, V. I., A. V. Shirokova, A. A. Zubochenko, I. V. Belova, E. N. Grunina, I. L. Danilova e O. A. Serebryakova. "Assessment of chemical mutagens by a complex of features in the selection of garlic". In CURRENT STATE, PROBLEMS AND PROSPECTS OF THE DEVELOPMENT OF AGRARIAN SCIENCE. Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea”, 2020. http://dx.doi.org/10.33952/2542-0720-2020-5-9-10-72.

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Some positive effect of chemical mutagen treatments of air garlic bulbs on the morphometric parameters and economically valuable traits of winter garlic bulbs in the second generation was established.
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Crespi, C. I., Robert Langenbach, Frank J. Gonzalez, Harry V. Gelboin e B. W. Penman. "Development and application of human cell lines engineered to metabolically activate structurally diverse environmental mutagens". In Environmental Sensing '92, editado por Tuan Vo-Dinh e Karl Cammann. SPIE, 1993. http://dx.doi.org/10.1117/12.140238.

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Zhang, Yi, Lixue Wen, Haiyan Bao, Yingying Nie, Yan Feng e Zhilong Xiu. "Secondary Metabolism Variation of a Marine Fungus Following Treatment with Dielectric Barrier Discharge Plasma and Chemical Mutagens". In International Conference on Biomedical and Biological Engineering. Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/bbe-16.2016.40.

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Van, N., e K. Popad'in. "Establishment of the mutational signature of the main mutagens of the mitochondrial genome: analysis of experimental data". In ChemBioSeasons 2022. Kemerovo State University, 2022. http://dx.doi.org/10.21603/chembioseasons2022-6.

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Melkonian, Stephanie C., Carrie R. Daniel, Yuanqing Ye, Nizar M. Tannir, Jose A. Karam, Surena F. Matin, Christopher G. Wood e Xifeng Wu. "Abstract 836: Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in renal cell carcinoma etiology". In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-836.

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Tasevska, Natasa, Rashmi Sinha, Victor Kipnis, Doug Midthune, Amy Subar, Neal Caporaso, Arthur Schatzkin e Amanda Cross. "Abstract B134: Meat, meat cooking methods, meat mutagens and heme iron as risk factors for lung cancer in the NIH-AARP Diet and Health Study". In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-b134.

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Basak, Subhash, Subhash Basak, Subhash Basak, Subhabrata Majumdar e Subhash Basak. "Two QSAR Paradigms- Congenericity Principle versus Diversity Begets Diversity Principle- analyzed using computed mathematical chemodescriptors of homogeneous and diverse sets of chemical mutagens". In MOL2NET, International Conference on Multidisciplinary Sciences. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/mol2net-1-b036.

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Takanashi, H., T. Nakajima, A. Ohki, S. Kokubu, M. Hirata e T. Hano. "Mutagen formation potential of river water and removal of mutagen precursor by activated carbon". In RIVER BASIN MANAGEMENT 2007. Southampton, UK: WIT Press, 2007. http://dx.doi.org/10.2495/rm070491.

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Relatórios de organizações sobre o assunto "Mutagens"

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Fanning, Thomas G. Line-1 Retrotransposons as Mutagens in Human Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, outubro de 1995. http://dx.doi.org/10.21236/ada303469.

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Fanning, Thomas G. Line-1 Retrotransposons as Mutagens in Human Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, outubro de 1997. http://dx.doi.org/10.21236/ada341479.

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Geacintov, N. E. Base sequence effects on interactions of aromatic mutagens with DNA. Office of Scientific and Technical Information (OSTI), setembro de 1992. http://dx.doi.org/10.2172/7198706.

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Geacintov, N. E. Base sequence effects on interactions of aromatic mutagens with DNA. Office of Scientific and Technical Information (OSTI), setembro de 1991. http://dx.doi.org/10.2172/5047004.

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Ames, B. N. The detection and analysis of mutagens: Final report, 1968--1986. Office of Scientific and Technical Information (OSTI), janeiro de 1989. http://dx.doi.org/10.2172/6171667.

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Geacintov, N. Base sequence effects on interactions of aromatic mutagens with DNA. Office of Scientific and Technical Information (OSTI), agosto de 1990. http://dx.doi.org/10.2172/6368272.

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Geacintov, N. Base sequence effects on interactions of aromatic mutagens with DNA (deoxyribonucleic acid). Office of Scientific and Technical Information (OSTI), outubro de 1989. http://dx.doi.org/10.2172/5643342.

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Geacintov, N. E. Base sequence effects on interactions of aromatic mutagens with DNA. Progress report, September 1, 1991--August 31, 1992. Office of Scientific and Technical Information (OSTI), setembro de 1992. http://dx.doi.org/10.2172/10183016.

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Puck, T. T. Measurement of mutation and repair in mammalian cells/action of specific mutagens and antimutagens/genome exposure reaction in cancer and other disease conditions. Final subcontract report, April 1, 1996- March 31, 1996. Office of Scientific and Technical Information (OSTI), setembro de 1996. http://dx.doi.org/10.2172/378934.

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Roderick, T. H. Improved mutagen testing systems in mice. Office of Scientific and Technical Information (OSTI), janeiro de 1992. http://dx.doi.org/10.2172/6732389.

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