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Artigos de revistas sobre o tema "Mr 2600"

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Autor: Grafiati

Publicado: 25 de julho de 2024

Última modificação: 29 de julho de 2024

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1

Nikolaev, A. K., E. S. Demenin e K. I. Plotnikova. "Research of Application of Anti-Turbulent and Depressor Additives in Pipeline Transport of High Viscosity Oils". Oil and Gas Technologies 137, n.º 6 (2021): 54–56. http://dx.doi.org/10.32935/1815-2600-2021-137-6-54-56.

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The use of anti-turbulent and depressant additives makes it possible to increase the efficiency of oil pipelines transporting high-viscosity oil. In this method, the principle of increasing the efficiency of transportation is based on reducing the hydraulic resistance and increasing the fluidity of oil. The work carried out a theoretical study of the existing types of anti-turbulent and depressant additives. This article presents an experimental study of the effect of the MR 1088 depressant additive on an oil sample from the Usa – Ukhta main oil pipeline.

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Negrine, R., e P. Bull. "'Mr Malik, to Represent the People of Dewsbury Do You Need a 2600 Cinema System Paid for by the Taxpayer?' An Analysis of British Television News Coverage of the 2009 MPs' 'Expenses Scandal'". Parliamentary Affairs 68, n.º 3 (25 de maio de 2014): 573–91. http://dx.doi.org/10.1093/pa/gsu009.

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Lilley, Kate, Andrew Swayne, Emily Watson, Rachel Kee, David Wong, Alexander Lehn, Helen Brown et al. "058 ANTI-CASPR2-ANTIBODY associated encephalitis in a 63-year old male with chronic lymphocytic leukaemia". Journal of Neurology, Neurosurgery & Psychiatry 89, n.º 6 (24 de maio de 2018): A24.1—A24. http://dx.doi.org/10.1136/jnnp-2018-anzan.57.

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IntroductionThis case from a tertiary neurology centre reports a novel association between the emerging clinical entity of anti-contactin associated protein-2 (CASPR-2) antibody encephalitis and chronic lymphocytic leukaemia (CLL).CaseWe describe a 63 year old Maori male truck-driver who presented with progressive altered personality, speech, cognition and perception over 9 months. The patient also developed choreiform movements, broad-based gait, incontinence, sleep apnoea with type 2 respiratory failure and episodic loss of consciousness. 12 months prior, he had been diagnosed with low-risk CLL, for which he remained untreated. MRI of the brain revealed mid-sagittal bilateral mid-temporal T2/FLAIR hyperintensities. Cerebrospinal fluid examination showed a mononuclear pleocytosis (WCC 270×10^6/L) with 15% of these CD5/CD19/CD23 positive and 92% CD3/CD5 positive CD 19 negative on flow cytometry, protein was also elevated at 2600 mg/L. The interplay between CLL and inflammation is uncertain. Anti-Caspr2-antibody was identified in CSF and serum. The patient was treated with a combination of fludarabine, cyclophosphamide, rituximab, dexamethasone and intravenous immunoglobulin (IVIG). Clinical status improved and antibody titre decreased from 580 to 241 pM in three weeks and to 55pM (negative <85 pM) at five months. Symptoms worsened when IVIG doses were missed. He returned home after inpatient rehabilitation, showed striking clinical improvement at 12 month follow-up and continues on maintenance IVIG therapy.ConclusionWhilst paraneoplastic VGKC encephalitis has been described associated with a number of malignancies, this is the first reported case of CASPR-2 antibody present in association with CLL.References. Van Sonderen A, Petit-Pedrol M, Dalmau J, Titulaer MJ. The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis. Nature Reviews Neurology2017;13(5):290–301.. Nogai H, Israel-Willner H, Zschenderlein R, Pezzutto A. Improvement in Paraneoplastic Limbic Encephalitis after Systemic Treatment with Rituximab in a Patient with B-Cell Chronic Lymphocytic Leukaemia. Case Reports in Haematology2013;2013:Article ID958704.. Van Sonderen A, Ariño H, Petit-Pedrol M, et al. The Clinical Spectrum of Caspr2 antibody-associated disease. Neurology2016;87:521–528.. Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, et al. Paraneoplastic limbic encephalitis: Neurological symptoms, immunological findings and tumour association in 50 patients. Brain2000;123:1481–1494.

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Wagner, B. J., e J. W. Margolis. "Common epitopes of bovine lens multicatalytic-proteinase-complex subunits". Biochemical Journal 257, n.º 1 (1 de janeiro de 1989): 265–69. http://dx.doi.org/10.1042/bj2570265.

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Component polypeptides of both the bovine lens and pituitary multicatalytic proteinase complexes demonstrate different immunoreactivities with a polyclonal antiserum raised against the purified pituitary enzyme. Four (Mr 24000, 26000, 34000 and 38000) of eight bands that have been resolved by SDS/polyacrylamide-gel electrophoresis are stained in immunoblot experiments. Monospecific antibodies obtained from this antiserum by affinity purification from the 38000- and 34000-Mr bands of the lens enzyme bound equally well to either band, but showed little or no binding to the 26000- and 24000-Mr bands upon immunoblotting. Antibody affinity-purified from the 24000-Mr band showed comparable binding to the 24000-, 34000- or 38000-Mr band. One explanation of these results is that the 24000-Mr polypeptide is derived from the higher-Mr polypeptide(s) and has lost some of the common immunodeterminants.

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BRUSCHI, Mireille, Gisèle LEROY, Jacques BONICEL, Daniel CAMPESE e Alain DOLLA. "The cytochrome c3 superfamily: amino acid sequence of a dimeric octahaem cytochrome c3 (Mr 26,000) isolated from Desulfovibrio gigas". Biochemical Journal 320, n.º 3 (15 de dezembro de 1996): 933–38. http://dx.doi.org/10.1042/bj3200933.

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Cytochrome c3 (Mr 26000) isolated from Desulfovibrio gigas is a dimeric cytochrome consisting of two identical subunits of 109 amino acids, each of which contains four haem groups. On the basis of its amino acid sequence, this cytochrome clearly belongs to the cytochrome c3 superfamily, and will be classified in class III of the c-type cytochromes as defined by Ambler [(1980) in From Cyclotrons to Cytochromes (Robinson, A. B. and Kaplan, N. O., eds.), pp. 263–279, Academic Press, London]. It contains ten cysteine and nine histidine residues in each subunit, and eight cysteines and eight histidines linked to the four haem groups were found to be invariant on alignment of all known cytochrome c3 sequences. Two intermolecular disulphide bridges have been determined between cysteine residues 5 and 46 of the two monomers. Cytochrome c3 (Mr 26000) from D. gigas is clearly different from cytochrome c3 (Mr 13000) from the same strain, with which it shows only 27% sequence identity. Compared with cytochrome c3 (Mr 26000) from D. desulfuricans Norway, the three-dimensional structure of which has been determined, 26.95% of the residues have been conserved. In the enzyme from D. desulfuricans Norway, hydrophobic interactions have been described across the dimer interface. Residues involved in similar interactions seem to be well conserved in the equivalent D. gigas cytochrome. This sequence provides structural data to allow specification of this new subclass of polyhaem cytochromes. Furthermore, D. gigas cytochrome c3 (Mr 26000) is the first polyhaem cytochrome shown to contain two disulphide bridges linking two identical subunits, which could induce more rigid folding. The folding and the evolution of this family of polyhaem cytochromes are discussed.

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Buonincontri, Guido, e Stephen J. Sawiak. "MR fingerprinting with simultaneous B1 estimation". Magnetic Resonance in Medicine 76, n.º 4 (28 de outubro de 2015): 1127–35. http://dx.doi.org/10.1002/mrm.26009.

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Liu, Yifei, Thomas J. Royston, Dieter Klatt e E. Douglas Lewandowski. "Cardiac MR elastography of the mouse: Initial results". Magnetic Resonance in Medicine 76, n.º 6 (9 de janeiro de 2016): 1879–86. http://dx.doi.org/10.1002/mrm.26030.

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Michielsen, Katrijn, Joke Meersschaert, Frederik De Keyzer, Mieke Cannie, Jan Deprest e Filip Claus. "MR volumetry of the normal fetal kidney: reference values". Prenatal Diagnosis 30, n.º 11 (23 de agosto de 2010): 1044–48. http://dx.doi.org/10.1002/pd.2607.

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Dittmann, Florian, Sebastian Hirsch, Heiko Tzschätzsch, Jing Guo, Jürgen Braun e Ingolf Sack. "In vivo wideband multifrequency MR elastography of the human brain and liver". Magnetic Resonance in Medicine 76, n.º 4 (20 de outubro de 2015): 1116–26. http://dx.doi.org/10.1002/mrm.26006.

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Dragomir, S. S. "Second derivative Lipschitz type inequalities for an integral transform of positive operators in Hilbert spaces". Extracta Mathematicae 37, n.º 2 (1 de dezembro de 2022): 261–82. http://dx.doi.org/10.17398/2605-5686.37.2.261.

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For a continuous and positive function w (λ), λ > 0 and µ a positive measure on (0, ∞) we consider the following integral transform D (w, µ) (T ) := ∫0∞w (λ) (λ + T ) −1 dµ (λ) , where the integral is assumed to exist for T a positive operator on a complex Hilbert space H. We show among others that, if A ≥ m 1 > 0, B ≥ m 2 > 0, then ||D (w, µ) (B) − D (w, µ) (A) − D (D (w, µ)) (A) (B − A)|| ≤|B − A|2×[D(w,µ)(m2)−D(w,µ)(m1)−(m2- m1)D’(w,µ)(m1)]/(m2−m1)2 if m1≠m2, ≤ D’’(w, µ)(m)/2 if m1=m2=m, where D (D (w, µ)) is the Fréchet derivative of D (w, µ) as a function of operator and D’’(w, µ) is the second derivative of D (w, µ) as a real function. We also prove the norm integral inequalities for power r ∈ (0, 1] and A, B ≥ m > 0, ||∫01((1−t)A+tB)r−1dt−((A+B)/2)r−1|| ≤ (1−r) (2−r) mr−3||B−A||2/24 and ||((Ar−1+Br−1 )/2) − ∫01((1−t) A+tB)r−1dt|| ≤ (1−r) (2−r) mr−3||B − A||2/12.

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Chen, Kevin T., Stephanie Salcedo, Daniel B. Chonde, David Izquierdo-Garcia, Michael A. Levine, Julie C. Price, Bradford C. Dickerson e Ciprian Catana. "MR-assisted PET motion correction in simultaneous PET/MRI studies of dementia subjects". Journal of Magnetic Resonance Imaging 48, n.º 5 (8 de março de 2018): 1288–96. http://dx.doi.org/10.1002/jmri.26000.

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Kobayashi, Naoki, Takaaki Hosoya, Michito Adachi, Tamami Haku e Koichi Yamaguchi. "Virtual MR microscopy for unruptured aneurysm". Computer Methods and Programs in Biomedicine 66, n.º 1 (julho de 2001): 99–103. http://dx.doi.org/10.1016/s0169-2607(01)00142-0.

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Yamada, Yoshiya, Evangelia Katsoulakis, Ilya Laufer, Michael Lovelock, Ori Barzilai, Lily A. McLaughlin, Zhigang Zhang et al. "The impact of histology and delivered dose on local control of spinal metastases treated with stereotactic radiosurgery". Neurosurgical Focus 42, n.º 1 (janeiro de 2017): E6. http://dx.doi.org/10.3171/2016.9.focus16369.

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OBJECTIVE An analysis of factors contributing to durable radiographic control of spinal metastases was undertaken, drawing from a large single-institution database in an attempt to elucidate indications and dose requirements for successful treatment. METHODS All patients treated at a single institution with stereotactic radiosurgery (SRS) of the spine as first-line therapy were assessed for local progression of the treated site, defined as radiographic enlargement of the treated tumor and/or biopsy-proven evidence of active tumor cells. All patients were followed with CT, PET, or MR imaging every 3–6 months until death. Treatment decisions were made by a multidisciplinary team of radiation oncologists, neurosurgeons, and neuroradiologists. Target volumes were defined according to the international consensus guidelines and were reviewed in a multidisciplinary conference. Image-guided techniques and intensity modulation were used for every case. The tumor's histological type, gross tumor volume (GTV), dose that covers 95% of the GTV (GTV D95), percentage of GTV covered by 95% of the prescribed dose (GTV V95), planning target volume (PTV), dose that covers 95% of the PTV (PTV D95), and percentage of PTV covered by 95% of the prescribed dose (PTV V95) were analyzed for significance in relation to local control, based on time to local progression. RESULTS A total of 811 lesions were treated in 657 patients between 2003 and 2015 at a single institution. The mean follow-up and overall survival for the entire cohort was 26.9 months (range 2–141 months). A total of 28 lesions progressed and the mean time to failure was 26 months (range 9.7–57 months). The median prescribed dose was 2400 cGy (range 1600–2600 cGy). Both GTV D95 and PTV D95 were highly significantly associated with local failure in univariate analysis, but GTV and PTV and histological type did not reach statistical significance. The median GTV D95 for the cohort equal to or above the GTV D95 1830 cGy cut point (high dose) was 2356 cGy, and it was 1709 cGy for the cohort of patients who received less than 1830 cGy (low dose). In terms of PTV D95, the median dose for those equal to or above the cut point of 1740 cGy (high dose) was 2233 cGy, versus 1644 cGy for those lesions below the PTV D95 cut point of 1740 cGy (low dose). CONCLUSIONS High-dose single-session SRS provides durable long-term control, regardless of the histological findings or tumor size. In this analysis, the only significant factors predictive of local control were related to the actual dose of radiation given. Although the target volumes were well treated with the intended dose, those lesions irradiated to higher doses (median GTV D95 2356 cGy, minimum 1830 cGy) had a significantly higher probability of durable local control than those treated with lower doses (median PTV D95 2232 cGy, minimum of 1740 cGy) (p < 0.001). Patients in the high-dose cohort had a 2% cumulative rate of local failure. Histological findings were not associated with local failure, suggesting that radioresistant histological types benefit in particular from radiosurgery. For patients with a favorable prognosis, a higher dose of SRS is important for long-term outcomes.

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Czjzek, M., F. Guerlesquin, M. Bruschi e R. Haser. "Crystal structure of a dimeric octaheme cytochrome c3 (Mr 26000) from Desulfovibrio desulfuricans Norway". Structure 4, n.º 4 (abril de 1996): 395–404. http://dx.doi.org/10.1016/s0969-2126(96)00045-7.

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Angelidis, P. A. "Very fast approximate reconstruction of MR images". Computer Methods and Programs in Biomedicine 57, n.º 3 (novembro de 1998): 155–60. http://dx.doi.org/10.1016/s0169-2607(98)00034-0.

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Rincon, Esther, Irene Rodriguez-Guidonet, Paula Andrade-Pino e Carlos Monfort-Vinuesa. "Mixed Reality in Undergraduate Mental Health Education: A Systematic Review". Electronics 12, n.º 4 (18 de fevereiro de 2023): 1019. http://dx.doi.org/10.3390/electronics12041019.

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The landscape of Extended Reality (ER), which includes Virtual Reality (VR), Augmented Reality (AR), and Mixed Reality (MR) is rapidly changing. However, despite the promising results from many randomized controlled trials (RCTs) developed on healthcare environments, there is a lack of standardization, specifically to determine their effectiveness in academic settings. To our best knowledge, this is the first systematic review addressing the efficacy of MR to enhance learning and skills acquisition in undergraduate mental health education. The purposes of this study were to review the scientific literature of those studies involving MR and undergraduate mental health education, to answer the two following questions: (1) Is MR useful to enhance the acquisition of knowledge and skill training in undergraduate mental health education, and (2) Which are the advantages and disadvantages that should be addressed to successfully develop MR in undergraduate mental health education? We conducted a systematic review of the peer-reviewed literature from EBSCO, Ovid, PubMed, and Scopus y WOS (Web of Science), following the PRISMA statements and using “mixed reality + education”, “mixed reality + student”, “mixed reality + undergraduate”, and “mixed reality + mental health”, as keywords. Those studies published between 2012 to present, in English or Spanish language, were reviewed. A total of 2608 records were retrieved, and only 6 publications met the inclusion criteria, and were finally included. MR training used was varied. There were no studies providing specific outcomes regarding the student’s acquired knowledge (theoretical concepts) after using MR. Several strengths and weaknesses of using MR with students were discussed. The results will be useful to develop innovative MR strategies to improve undergraduate mental health education, due to the lack of studies focused on this topic.

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Whitaker, John, Cory M. Tschabrunn, Jihye Jang, Eran Leshem, Mark O'Neill, Warren J. Manning, Elad Anter e Reza Nezafat. "Cardiac MR Characterization of left ventricular remodeling in a swine model of infarct followed by reperfusion". Journal of Magnetic Resonance Imaging 48, n.º 3 (9 de março de 2018): 808–17. http://dx.doi.org/10.1002/jmri.26005.

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Henrique, M. R. F., J. L. P. Ramos-Júnior, R. B. Flatschart, S. P. C. Barroso, M. B. Heinemann, F. G. da Fonseca, J. M. Granjeiro, V. de Souza e A. V. Folgueras-Flatchart. "Validation of a Bovine Viral Diarrhea Virus (BVDV) absolute quantification method by digital droplet PCR (ddPCR)." Journal of Physics: Conference Series 2606, n.º 1 (1 de outubro de 2023): 012016. http://dx.doi.org/10.1088/1742-6596/2606/1/012016.

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Abstract A increasingly common way for the diagnostics of viral agents is to carry out PCR from biological samples, which can detect their nucleic acid during the acute phase of the disease. Taking into account the need for quality control of PCR tests in laboratories accredited by ISO/IEC 17025:2017, we intend to carry out feasibility studies for the production of Reference Materials (MR) for these molecular tests, using BVDV in the matrix serum as a model. The first step for this goal was the validation of an analytical method for quantification of viral RNA to characterize the material under study. Primers and probe from a commercial qualitative assay kit designed for Real Time RT-PCR (VetMax Gold BVDV - Thermo Fisher) were used for quantification of BVDV by ddPCR. The technique was optimized and a Detection Limit of 13 copies/μL was determined, allowing a Quantification Limit of 38 copies/μL. The method showed to be linear over two orders of magnitude. The method will be used in the homogeneity study and long-term stability tests for the pilot batch of BVDV in Fetal Bovine Serum MR, a model for the production of MR intended for PCR of BVDV and other Flaviviridae.

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von Spiczak, Jochen, Manoj Mannil, Sebastian Kozerke, Hatem Alkadhi e Robert Manka. "3D image fusion of whole-heart dynamic cardiac MR perfusion and late gadolinium enhancement: Intuitive delineation of myocardial hypoperfusion and scar". Journal of Magnetic Resonance Imaging 48, n.º 4 (30 de março de 2018): 1129–38. http://dx.doi.org/10.1002/jmri.26020.

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Lee, Seyoung, Taegyu Um, Jeeyeon Lee, Peter Haseok Kim, Monica Yadav, Maria J. Chuchuca, Liam Il-Young Chung e Young Kwang Chae. "Abstract 3844: Clinical implications of mixed response on prognosis of non-small cell lung cancer (NSCLC) patients treated with Immunotherapy". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 3844. http://dx.doi.org/10.1158/1538-7445.am2024-3844.

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Abstract Background: Current methods for assessing the response of lung cancer patients to therapy (e.g. RECIST criteria) lack consideration for mixed response (MR) where some lesions increase while others decrease simultaneously. MR poses a challenge in deciding the continuation of therapy. Understanding the clinical implications of MR on patient prognosis within radiographic response categories is crucial for establishing effective treatment strategies for NSCLC. Methods: This study analyzed 177 NSCLC patients with ≥2 lesions receiving first-line systemic treatment with immunotherapy. Clinical response was evaluated by RECIST v1.1 and immune-related RECIST (irRECIST). MR was defined as the simultaneous presence of ≥1 lesion increase and ≥1 lesion decrease during therapy. Two different definitions of MR were utilized. Definition-A (MR-A): the simultaneous presence of one or more lesions increasing ≥5mm and one or more lesions decreasing ≥5mm during therapy (Δ [baseline - first follow-up] ≥ 5 mm); and Definition-B (MR-B): the simultaneous presence of one or more lesions increasing >1mm and one or more lesions decreasing >1mm during therapy (any Δ [baseline - first follow-up]). Subgroup analysis was conducted using 94 patients with only intrathoracic lesions. Results: Among the 177 patients, tumor responses based on RECIST were 3 CR (1.7%),42 PR (23.7%), 87 SD (49.2%), and 45 PD (25.4%). Based on irRECIST, responses were 3 CR (1.7%), 46 PR (26.0%), 89 SD (50.3%), and 39 PD (22.0%). MR-A and MR-B occurred in 19.8% (n=35) and 45.2% (n=80) of cases, respectively. In the irRECIST PD group, MR-A demonstrated significantly different median progression-free survival (mPFS) and median overall survival (mOS) compared to non-MR-A (p<0.020, p<0.005, respectively). The mPFS for MR-A group was 1.4 months (range 0.5-52.9) and non-MR-A group was 5.5 months (range 0.2-97.2) with the hazard ratio being 2.91 (95% CI 1.13-7.51). The mOS for MR-A and non-MR-A groups were 4.8 months (range 0.7-61.5) and 11.8 months (range 0.2-97.2), respectively, hazard ratio 4.87 (95% CI 1.43-16.56). No other significant results were found for other RECIST and irRECIST categories. Subgroup analysis of only intrathoracic lesion patients revealed no statistically significant results. Conclusion: Contrary to our hypothesis, MR did not modify prognosis within the RECIST or irRECIST category. MR-A or MR-B in the RECIST or irRECIST PD group did not show a better prognosis, indicating the complexity of mixed responses in NSCLC patients treated with immunotherapy. Further research with larger cohorts are warranted. Citation Format: Seyoung Lee, Taegyu Um, Jeeyeon Lee, Peter Haseok Kim, Monica Yadav, Maria J. Chuchuca, Liam Il-Young Chung, Young Kwang Chae. Clinical implications of mixed response on prognosis of non-small cell lung cancer (NSCLC) patients treated with Immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3844.

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Yadav, Monica, Jeeyeon Lee, Peter Haseok Kim, Maria J. Chuchuca, Taegyu Um, Liam Il-Young Chung, Yury S. Velichko e Young Kwang Chae. "Abstract 2576: Radiomic features of intrathoracic lesions can predict the mixed response in non-small cell lung cancer treated with immunotherapy". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 2576. http://dx.doi.org/10.1158/1538-7445.am2024-2576.

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Abstract Background: Although immunotherapy has emerged as a promising treatment for lung cancer, the decision to continue immunotherapy becomes challenging when mixed response (MR) occurs. This study is aimed to evaluate whether radiomic features from pre-treatment intrathoracic images can predict MR. Methods: 127 consecutive patients with NSCLC who received first line systemic treatment containing immunotherapy were included in this study. Chest CT scans were obtained at baseline and 1-3 times from 11 different CT scanners and harmonization method was applied to minimize scanner-related bias. The durable response of intrathoracic lesions (n=266) at least 24 weeks was evaluated based on RECIST 1.1 and irRECIST. MR was defined as the simultaneous presence of at least one lesion that increased and decreased in a single patient during immunotherapy and two different criteria of MR for the change of tumor lesions were applied: Definition-A (MR-A), Δ [baseline - first follow-up] ≥ 5 mm; Definition-B (MR-B), any change of Δ [baseline - first follow-up]. All intrathoracic lesions were identified and segmented by four different physicians. Radiomic features, including morphological, intensity, GLCM, GLRLM, GLSZM, and NGTDM, were extracted using LIFEX software (IMIV/CEA, Orsay, France). Confusion matrix was used to assess tumor responses, and area under the curve (AUC) for intrathoracic lesions was calculated. Results: Tumor responses based on irRECIST were CR (n=1, 0.8%), PR (n=33, 26.0%), SD (n=55, 43.3%), and PD (n=39, 30.7%). There were 10 cases (7.9%) of MR-A and 25 cases (19.7%) of MR-B. While the median progression-free survival (PFS) and overall survival (OS) in MR-A group were 22.9 (range, 0.5-50.6) and 23.5 (range, 1.1-42.2) months, those in MR-B group were 2.0 (range, 0.5-50.6) and 3.3 (range, 0.7-49.0) months respectively. While the overall sensitivity (SN) and specificity (SP) for MR-A in intrathoracic lesions were 0.55 and 0.87, those for MR-B were 0.52 and 0.71, respectively. The AUC for MR-A and MR-B were 0.71 and 0.62 respectively, and the AUC for durable response was 0.56. In the SD group, median PFS and OS were 3.3 (1.4-18.9) and 6.1 (4.8-26.2) in the MR-A group and 9.7 (0.7-18.9) and 23.9 (0.7-26.2) respectively in the MR-B group. Median PFS and OS were 18.2 (0.5-65.2) and 23.9 (0.9-55.3) respectively in the non-MR-A group and 18.2 (0.5-65.2) and 23.9 (0.9-55.3) respectively in the non-MR-B group. In the PD group, median PFS and OS were 23.5 (0.5-41.3) and 24.7 (1.1-42.2) respectively in the MR-A group and 5.1 (0.5-41.3) and 11.5 (1.1-49.0) respectively in the MR-B group. Median PFS and OS were 20.3 (0.7-71.4) and 37.1 (1.0-72.9) respectively in the non-MR-A group and 20.3 (0.7-71.4) and 37.1 (1.0-72.9) respectively in the non-MR-B group. Conclusion: The radiomic features in NSCLC patients who received immunotherapy may help predict MR in NSCLC patients treated with immunotherapy. Citation Format: Monica Yadav, Jeeyeon Lee, Peter Haseok Kim, Maria J. Chuchuca, Taegyu Um, Liam Il-Young Chung, Yury S. Velichko, Young Kwang Chae. Radiomic features of intrathoracic lesions can predict the mixed response in non-small cell lung cancer treated with immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2576.

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Heinonen, Tomi, Hannu Eskola, Prasun Dastidar, Päivi Laarne e Jaakko Malmivuo. "Segmentation of T1 MR scans for reconstruction of resistive head models". Computer Methods and Programs in Biomedicine 54, n.º 3 (novembro de 1997): 173–81. http://dx.doi.org/10.1016/s0169-2607(97)00027-8.

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Holländer, Igor, e Ivan Bajla. "Adaptive smoothing of MR brain images by 3D geometry-driven diffusion". Computer Methods and Programs in Biomedicine 55, n.º 3 (março de 1998): 157–76. http://dx.doi.org/10.1016/s0169-2607(97)00058-8.

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Todorov, T., A. Todorova, D. Avdjieva, P. Dimova, L. Angelova, R. Tincheva e V. Mitev. "Clinical and Molecular Data on Mental Retardation in Bulgaria". Balkan Journal of Medical Genetics 13, n.º 2 (1 de janeiro de 2010): 11–25. http://dx.doi.org/10.2478/v10034-010-0022-8.

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Clinical and Molecular Data on Mental Retardation in BulgariaMental retardation (MR) is clinically and genetically highly heterogeneous. We have done molecular genetic testing on 85 Bulgarian MR patients who were clinically classed as fragile X syndrome (FXS) (n = 32), Rett syndrome (RTT) (n = 36) and Prader-Willi/Angelman syndromes (PWS/AS) (n = 17). We tested for the fragile X MR 1 (FMR1), methyl-CpG binding protein 2 (MECP2), cyclin dependent kinase-like 5 (CDKL5), and Aristaless X (ARX) genes, and did methylation analyses of exon 1 of the small nuclear ribonucleoprotein polypeptide N (SNRPN), and multiplex ligation-dependent probe amplification (MLPA) analyses for large deletions/duplications, and for the methylation status of FMR1 and SNRPN genes. In the FXS group we only found four mutations in the FMR1 gene (12.5%). In the RTT group we found nine mutations in the MECP2 gene (25.0%) but no CDKL5 gene mutations. In the PWS/AS group we found nine mutations in the 15q11-q13 region (53%). Thus, we clarified the molecular basis in 26.0% of the patients. The proportion of genetically proved diagnoses in our RTT patients (25.0%) is relatively high and all these cases are due to MECP2 mutations. Despite the type of mutation, all these cases are very similar from the clinical point of view and well recognized in Bulgaria.

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Lötjönen, Jyrki. "Construction of patient-specific surface models from MR images: application to bioelectromagnetism". Computer Methods and Programs in Biomedicine 72, n.º 2 (outubro de 2003): 167–78. http://dx.doi.org/10.1016/s0169-2607(02)00125-6.

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Karonen, J. O., L. Östergaard, P. Vainio, K. Partanen, R. Vanninen, E. Vanninen, K. Korhonen et al. "Diffusion and perfusion MR imaging in acute ischemic stroke: a comparison to SPECT". Computer Methods and Programs in Biomedicine 66, n.º 1 (julho de 2001): 125–28. http://dx.doi.org/10.1016/s0169-2607(01)00146-8.

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MIRELS, Lily, J. Abigail MIRANDA e D. William BALL. "Characterization of the rat salivary-gland B1-immunoreactive proteins". Biochemical Journal 330, n.º 1 (15 de fevereiro de 1998): 437–44. http://dx.doi.org/10.1042/bj3300437.

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The B1-immunoreactive proteins (B1-IPs) are major secretory products of rat submandibular gland acinar-cell progenitors, and are also produced by neonatal and adult rat sublingual and parotid glands. In order to characterize the B1-IPs, we have previously isolated cDNA clones encoding rat parotid secretory protein (PSP; the predominant parotid B1-IP) and the related clone ZZ3, which is developmentally regulated in the neonatal submandibular gland. The remainder of the B1-IPs were uncharacterized. This report demonstrates that all of the B1-IPs are derived from the PSP and ZZ3 transcripts. Molecular cloning and Western-blot analyses using PSP- and ZZ3-specific antisera show that, of the B1-IPs, only PSP and neonatal submandibular gland protein A (SMGA) are products of the Psp gene. This finding corrects our previous assertion that SMGA is derived from ZZ3. Neonatal submandibular gland proteins B1 and B2, as well as apparent Mr 26000-28000 and Mr 18000-20000 forms in submandibular, sublingual and parotid glands, are derived from the gene encoding ZZ3 by differential N-glycosylation and by proteolytic cleavage. The apparent Mr 18000-20000 proteolytic products are significant in secretion product collected in vitro, but rare in gland homogenate and submandibular/sublingual saliva. The gene encoding ZZ3 has been named Smgb. Psp and Smgb are regulated similarly in the developing submandibular gland, but differently in the sublingual and parotid glands. The expression pattern of Psp is conserved between rat and mouse. However, no evidence for proteins derived from an Smgb-like gene was observed in neonatal mouse submandibular or sublingual glands.

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Suga, Daisaku, Yukihiro Ohtani, Toyozou Komiyama, Hideyuki Siotani, Tsunemitsu Matsuda, Isamu Mano, Junichi Makita e Yasuo Okabe. "260. Evaluation of improvement of the images with the PVA sheet 1". Japanese Journal of Radiological Technology 46, n.º 8 (1990): 1232. http://dx.doi.org/10.6009/jjrt.kj00003322383.

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Lansdown, Drew A., Robert Dawe, Gregory L. Cvetanovich, Nikhil N. Verma, Brian J. Cole, Bernard R. Bach, Gregory P. Nicholson, Anthony A. Romeo e Adam Blair Yanke. "Automated 3D MRI Allows for Accurate Evaluation of Glenoid Bone Loss as Compared to 3D CT". Orthopaedic Journal of Sports Medicine 6, n.º 7_suppl4 (1 de julho de 2018): 2325967118S0008. http://dx.doi.org/10.1177/2325967118s00089.

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Objectives: Glenoid bone loss is frequently present in the setting of recurrent shoulder instability. The magnitude of bone loss is an important determinant of the optimal surgical treatment. The current gold-standard for measurement of glenoid bone loss is three-dimensional (3D) reconstruction of a computed tomography (CT) scan. CT scans, however, carry an inherent risk of radiation and increased cost for a second modality. Magnetic resonance imaging (MRI) offers excellent soft tissue contrast and may allow resolution of bony structures to generate 3D reconstructions without a risk of ionizing radiation. We hypothesized that automated 3D MRI reconstruction would offer similar measurements of glenoid bone loss as recorded from a 3D CT scan in a clinical setting. Methods: A retrospective review was performed for fourteen patients who had both pre-operative MRI scan and CT scan of the shoulder. All MR scans were performed on a 1.5 T scanner (Siemens) utilizing a Dixon chemical shift separation sequence and the out-of-phase images with 0.90 mm slice thickness. Reconstructions of the glenoid were performed from axial images (Figure 1A) using an open-platform image processing system (3D Slicer; slicer.org). A single point on the glenoid was selected and a standard threshold was used to build a 3D model (Figure 1B). High-resolution CT scans underwent 3D reconstruction in Slicer based on Houndsfield Unit thresholding. Glenoid bone loss on both scans was measured with the Pico method by defining a circle of best fit using the inferior 2/3 of the glenoid and determining the percent area missing from this circle. Pearson’s correlation coefficient was utilized to determine the similarity between MR and CT based measurements. Statistical significance was defined as p<0.05. Results: The correlation between 3D MR and CT-based measurements of glenoid bone loss was excellent (r = 0.95, p<0.0001). The mean bone loss as measured by the 3D MR was 13.2 +- 7.2% and was 12.5 +- 8.6% for the 3D CT reconstruction (p=0.32). Bone loss in this cohort ranged from 3.7-25.4% on 3D MR and 1.4-26.0% on 3D CT. The root-mean-square difference between measurements was 2.7%. Conclusion: There was excellent agreement between automated 3D MR and 3D CT measurements of glenoid bone loss and minimal differences between these measurements. This reconstruction method requires minimal post-processing, no manual segmentation, and is obtained with widely-available MR sequences. This method has the potential to decrease the utilization for CT scans in determining glenoid bone loss. [Figure: see text]

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Polumiskova, A. O., S. I. Tevkin, T. M. Jussubaliyeva e M. S. Shishimorova. "INFLUENCE ON THE OUTCOME OF ART PROGRAMS OF FROZEN-THAWED BLASTOCYSTS EXPANDED ON FIVE OR SIX DAY". Reproductive Medicine, n.º 2(47) (20 de junho de 2021): 68–75. http://dx.doi.org/10.37800/rm2021-2-7.

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In order to increase the effectiveness of assisted reproductive technologies (ART) programs, it is essential to improve and develop conditions of embryo culture prior its transfer or cryopreservation of expanded blastocysts on the day 5 or 6. The aim of the study was to assess the effect of human blastocysts’ expansion timing on clinical pregnancy rate (CPR), miscarriage rate (MR) and take-home baby rate (THBR) in frozen-thawed cycles during ART programs. The study involved 2275 frozen embryo transfers (FET) of blastocysts expanded on the day 5 (group A) and 170 FET of blastocysts expanded on the day 6 (group B). The pregnancy rates in both groups were 50.8% and 46.5% respectively. There were no statistically significant differences in clinical pregnancy rate 37.4% and 37.0%, miscarriage rate 26.0% and 21.5% in both groups, respectively. THBR, as the main indicator of efficiency in the programs with transfer of post thawed expanded blastocysts on the day 5 (group A) or 6 (group B) were 36.5% and 35.2%, respectively (the difference is insignificant). In conclusion, in cryoprotocols the day of blastocyst expansion (day 5 or 6 of development) does not statistically affect PR, MR and THBR. In FET programs the quality of blastocyst (excellent and good) should be prioritized regardless of the day of cryopreservation.

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Tegas Tri Sakti, Kusuma Chandra Kirana e Didik Subiyanto. "Pengaruh Gaya Kepemimpinan Transformasional, Pelatihan, dan Kecerdasan Emosional terhadap Prestasi Kerja Karyawan PT. Daya Intiguna Yasa". Jurnal Kolaboratif Sains 5, n.º 8 (17 de agosto de 2022): 503–14. http://dx.doi.org/10.56338/jks.v5i8.2699.

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Sumber daya manusia merupakan salah satu faktor yang perlu dikelola dan dibutuhkan dengan baik oleh perusahaan. Penelitian ini bertujuan untuk mengetahui pengaruh gaya kepemimpinan transformasional, pelatihan dan kecerdasan emosional terhadap prestasi kerja PT Daya Intiguna Yasa. Penelitian ini merupakan penelitian kuantitatif dengan pengumpulan data menggunakan kuesioner. Analisis data dilakukan dengan menggunakan analisis regresi berganda menggunakan SPSS 26.00 for macOs. Gaya kepemimpinan transformasional dan kecerdasan emosional secara parsial berpengaruh signifikan terhadap prestasi kerja karyawan PT. Daya Intiguna Yasa, Pelatihan secara parsial tidak berpengaruh signifikan terhadap prestasi kerja karyawan PT. Daya Intiguna Yasa. Variabel gaya kepemimpinan transformasional, pelatihan, dan kecerdasan emosional secara simultan berpengaruh signifikan terhadap prestasi kerja PT. Daya Intiguna Yasa. Keterbatasan penelitian ini adalah penelitian ini hanya dilakukan pada PT Mr DIY di wilayah selatan jawa tengah, tidak dapat digunakan untuk menggeneralisasi ke wilayah lain.

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Barra, Vincent, e Jean-Yves Boire. "Segmentation of fat and muscle from MR images of the thigh by a possibilistic clustering algorithm". Computer Methods and Programs in Biomedicine 68, n.º 3 (junho de 2002): 185–93. http://dx.doi.org/10.1016/s0169-2607(01)00172-9.

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Kunz, Holger, Claus Derz, Thomas Tolxdorff e Johannes Bernarding. "Feature extraction and supervised classification of MR images to support proton radiation therapy of eye tumors". Computer Methods and Programs in Biomedicine 73, n.º 3 (março de 2004): 195–202. http://dx.doi.org/10.1016/s0169-2607(03)00074-9.

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Taylor, Kurt, Nancy McBride, Jian Zhao, Sam Oddie, Rafaq Azad, John Wright, Ole A. Andreassen et al. "The Relationship of Maternal Gestational Mass Spectrometry-Derived Metabolites with Offspring Congenital Heart Disease: Results from Multivariable and Mendelian Randomization Analyses". Journal of Cardiovascular Development and Disease 9, n.º 8 (27 de julho de 2022): 237. http://dx.doi.org/10.3390/jcdd9080237.

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Background: It is plausible that maternal pregnancy metabolism influences the risk of offspring congenital heart disease (CHD). We sought to explore this through a systematic approach using different methods and data. Methods: We undertook multivariable logistic regression of the odds of CHD for 923 mass spectrometry (MS)-derived metabolites in a sub-sample of a UK birth cohort (Born in Bradford (BiB); N = 2605, 46 CHD cases). We considered metabolites reaching a p-value threshold <0.05 to be suggestively associated with CHD. We sought validation of our findings, by repeating the multivariable regression analysis within the BiB cohort for any suggestively associated metabolite that was measured by nuclear magnetic resonance (NMR) or clinical chemistry (N = 7296, 87 CHD cases), and by using genetic risk scores (GRS: weighted genetic risk scores of single nucleotide polymorphisms (SNPs) that were associated with any suggestive metabolite) in Mendelian randomization (MR) analyses. The MR analyses were performed in BiB and two additional European birth cohorts (N = 38,662, 319 CHD cases). Results: In the main multivariable analyses, we identified 44 metabolites suggestively associated with CHD, including those from the following super pathways: amino acids, lipids, co-factors and vitamins, xenobiotics, nucleotides, energy, and several unknown molecules. Of these 44, isoleucine and leucine were available in the larger BiB cohort (NMR), and for these the results were validated. The MR analyses were possible for 27/44 metabolites and for 11 there was consistency with the multivariable regression results. Conclusions: In summary, we have used complimentary data sources and statistical techniques to construct layers of evidence. We found that pregnancy amino acid metabolism, androgenic steroid lipids, and levels of succinylcarnitine could be important contributing factors for CHD.

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Haladjian, J., P. Bianco, F. Guerlesquin e M. Bruschi. "Kinetic studies of the electron exchange reaction between the octaheme cytochrome c3 (Mr 26000) and the hydrogenase from Desulfovibrio desulfuricans Norway". Biochemical and Biophysical Research Communications 179, n.º 1 (agosto de 1991): 605–10. http://dx.doi.org/10.1016/0006-291x(91)91414-8.

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Kim, Sanghyeon, Myongjin Kang e Sunseob Choi. "A case report of sporadic hemiplegic migraine associated cerebral hypoperfusion: comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MR imaging". European Journal of Pediatrics 175, n.º 2 (7 de agosto de 2015): 295–98. http://dx.doi.org/10.1007/s00431-015-2609-2.

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Andreou, A., D. M. Koh, D. J. Collins, M. Blackledge, T. Wallace, M. O. Leach e M. R. Orton. "Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases". European Radiology 23, n.º 2 (6 de outubro de 2012): 428–34. http://dx.doi.org/10.1007/s00330-012-2604-1.

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Liu, Xiang, Rajiv Mangla, Wei Tian, Xing Qiu, Dongmei Li, Kevin A. Walter, Sven Ekholm e Mahlon D. Johnson. "The preliminary radiogenomics association between MR perfusion imaging parameters and genomic biomarkers, and their predictive performance of overall survival in patients with glioblastoma". Journal of Neuro-Oncology 135, n.º 3 (9 de setembro de 2017): 553–60. http://dx.doi.org/10.1007/s11060-017-2602-x.

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Wu, Lian-Ming, Jian-Rong Xu, Hai-Yan Gu, Jia Hua, E. Mark Haacke e Jiani Hu. "Predictive value of T2-weighted imaging and contrast-enhanced MR imaging in assessing myometrial invasion in endometrial cancer: a pooled analysis of prospective studies". European Radiology 23, n.º 2 (4 de agosto de 2012): 435–49. http://dx.doi.org/10.1007/s00330-012-2609-9.

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Shin, Y. R., S. E. Rha, B. G. Choi, S. N. Oh, M. Y. Park e J. Y. Byun. "Uterine cervical carcinoma: a comparison of two- and three-dimensional T2-weighted turbo spin-echo MR imaging at 3.0 T for image quality and local-regional staging". European Radiology 23, n.º 4 (7 de agosto de 2012): 1150–57. http://dx.doi.org/10.1007/s00330-012-2603-2.

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ROSSOLINI, Gian Maria, Nicola FRANCESCHINI, Maria Letizia RICCIO, Paola Sandra MERCURI, Mariagrazia PERILLI, Moreno GALLENI, Jean-Marie FRERE e Gianfranco AMICOSANTE. "Characterization and sequence of the Chryseobacterium (Flavobacterium) meningosepticum carbapenemase: a new molecular class B β-lactamase showing a broad substrate profile". Biochemical Journal 332, n.º 1 (15 de maio de 1998): 145–52. http://dx.doi.org/10.1042/bj3320145.

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The metallo-β-lactamase produced by Chryseobacterium(formerly Flavobacterium) meningosepticum,which is the flavobacterial species of greatest clinical relevance, was purified and characterized. The enzyme, named BlaB, contains a polypeptide with an apparent Mr of 26000, and has a pI of 8.5. It hydrolyses penicillins, cephalosporins (including cefoxitin), carbapenems and 6-β-iodopenicillanate, a mechanism-based inactivator of active-site serine β-lactamases. The enzyme was inhibited by EDTA, 1-10 phenanthroline and pyridine-2,6-dicarboxylic acid, with different inactivation parameters for each chelating agent. The C. meningosepticum blaBgene was cloned and sequenced. According to the G+C content and codon usage, the blaBgene appeared to be endogenous to the species. The BlaB enzyme showed significant sequence similarity to other class B β-lactamases, being overall more similar to members of subclass B1, which includes the metallo-enzymes of Bacillus cereus(Bc-II) and Bacteroides fragilis(CcrA) and the IMP-1 enzyme found in various microbial species, and more distantly related to the metallo-β-lactamases of Aeromonasspp. (CphA, CphA2 and ImiS) and of Stenotrophomonas maltophilia(L1).

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Khamiruyev, T. N., B. Z. Bazaron e S. M. Dashinimaev. "Ecological and physiological mechanisms of adaptation of young sheep in the conditions of Transbaikal". Siberian Herald of Agricultural Science 52, n.º 3 (26 de julho de 2022): 61–70. http://dx.doi.org/10.26898/0370-8799-2022-3-7.

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The results of studying the adaptive abilities of young sheep depending on their origin and their relationship with productivity are presented. Temperature, velocity and humidity at birth of lambs (April) were 4.7 °C, 4.2 m/s and 17.7%, at the age of 6 months (October) - 1.0 °C below zero, 4.9 m/s and 33.7% respectively. The best indicators of live weight up to 6 months of age are shown by medium-wool young Aginskaya breed. Young rams at the age of 6 months had an advantage over their fine-wool counterparts of Transbaikal breed by 3.7% in terms of average live weight, and the gimmers by 6.3% (p > 0.05). The rams of the Transbaikal breed had the best height measurements of the body by 0.4 cm at the withers and by 1.3 cm in the height at hips. The Aginskaya breed peers were distinguished by better volume and latitude measurements, including oblique torso length and chest depth. The Aginskaya breed has longer ears (23,2-23,8%), neck (9,7-17,5%) and head (1,2- 2,5%), narrower forehead (11,5-17,6%) and less voluminous neck (5,1-7,2%) than their fine-wool counterparts. Clinical and hematological parameters were within the physiological norm. The lowest body temperature on the skin surface of the experimental youngsters at birth and at 6 months of age was noted in the ear area (25.2-26.0 °С), the highest - on the central part of the abdomen (29.3- 33.4 °С). In terms of skin thickness, depending on the origin of the sheep, the greatest difference was noted in the SCP, MR-12, and SCP areas. In fine-wool individuals, it is 28.0-39.1% thicker in the SCP, 9.7-46.2% thicker in the MR-12, and 25.0-43.5% thicker in the SCP. In test specimens a positive correlation of live weight with the height at hips (0.591-0.906), with the girth of the metacarpel (0.133-0.240), and with the width of the forehead (0.173-0.590) was detected. There was a correlation between live weight and head and neck length in medium-wool breed individuals (0.060- 0.463 and 0.147-0.394), as well as a weak correlation with skin thickness on MR-12. In fine-wool counterparts, there is a medium correlation between live weight and neck girth (0.490-0.553) and skin thickness in the SCP area (0.469-0.755).

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Hori, Masato, Toshiro Kimura, Akira Hiraga, Masatsugu Minamide, Shingo Okazaki, Hiroshi Akagi, Hisashi Hanada, Keishiro Kawamura e kouichi Utsumi. "260. Whole left ventricular mass measured rapidly with non-gated MRI". Japanese Journal of Radiological Technology 47, n.º 8 (1991): 1292. http://dx.doi.org/10.6009/jjrt.kj00003324001.

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Novitasari, Novitasari, Tita Talitha e Dewi Agustini Susanto. "Penggunaan Metode Goal Programming Untuk Optimasi Perancangan Proses Produksi Produk Wingko Babat". Applied Industrial Engineering Journal 1, n.º 1 (4 de outubro de 2018): 47–52. http://dx.doi.org/10.33633/aiej.v1i1.1725.

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One form of actual problems in the manufacturing industry is how to maximize the value of profit with various constraints or constraints. The problem is not only experienced by big industry but also small industry like in UD. Wingko trip Mr. Moel who is trying to maximize the value of profit by estimating the amount of wingko trips that must be produced because there is a problem of the difference in the amount of production with one of the limits associated with the production capacity. The resulting production difference causes the amount of wingko trip or excess production in certain month. The method of Goal Programming is the one method of optimization with more than one objective that are interconnected with each other or conflicting to solve the problem. This research uses the Goal Programming method to optimize the production amount and maximize the profit of the product, and to forecast the number of forward demand by using the number of the past request to know how many products must be produced. Goal Programming Formulations use forecasting as decision variables for optimization of results in compliance with criteria and constraints. The results show the optimal amount of production in January - December 2017 are 29860 bag wingko original, 24000 bag wingko chocolate chocolate, 26004 bag wingko tripe jackfruit and 18084 bag wingko tripe durian with total profit in 2017 is Rp. 429.736.600.Â

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Attauabi, M., G. R. Madsen, F. Bendtsen, R. Wilkens, J. F. K. F. Ilvemark, K. Theede, T. Boysen, J. T. Bjerrum, J. B. Seidelin e J. Burisch. "P238 Symptom burden and indolent disease in newly diagnosed patients with ulcerative colitis and Crohn’s disease - a Copenhagen IBD Inception Cohort Study". Journal of Crohn's and Colitis 16, Supplement_1 (1 de janeiro de 2022): i285—i287. http://dx.doi.org/10.1093/ecco-jcc/jjab232.365.

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Abstract Background The early course of ulcerative colitis (UC) and Crohn’s disease (CD) is difficult to predict, particularly regarding identifying patients for whom an indolent course might be expected. Therefore, we aimed to investigate the initial course of UC and CD and clinical predictors hereof in a generalizable population-based inception cohort. Methods We initiated a prospective population-based inception cohort of newly diagnosed patients with UC and CD between May 1st, 2021 and November 1st, 2021, according to the Copenhagen IBD Criteria within the geographical uptake area of Hvidovre University Hospital and Herlev University Hospital. All patients were examined systematically by IBD specialists at diagnosis using endoscopy, magnetic resonance (MR) enterography, and patient-reported measures including Simple Clinical Colitis Index (SCCAI) and Harvey-Bradshaw Index (HBI) for UC and CD, respectively. Indolent disease presentation was defined as the absence of UC or CD-related hospitalization, surgery, or decision to start steroid, immunomodulator, or biologic therapy within three months of follow-up. In addition, well-recognized predictors of long-term disease course of UC and CD were a priori defined and implemented in a univariate logistic model, and factors with a p-value smaller than 0.10 were included in the multivariate model. Results The study included 63 adult patients with UC and 50 with CD. At diagnosis, 23 (36.5%) and 13 (26.0%) patients with UC and CD were in clinical remission according to their SCCAI or HBI score, respectively (Table 1). The symptomatic disease burden is outlined in Table 2–3. Interestingly, well-recognized risk factors for the long-term disease course of UC and CD, including disease extent, behavior, baseline endoscopy, MR enterography, and serologic data, did not predict the initial disease course in a multivariable analysis (Table 4). However, C-reactive protein <10 mg/L were associated with an indolent course of UC (adjusted odds ratio=6.2 (95% confidence interval 1.3–38.9), p=0.03). Conclusion The preliminary data from the ongoing prospective population-based cohort study indicate that very heterogenous disease course patterns might be experienced very early. As initial disease control is considered critical for long-term outcomes, this study highlights the inapplicability of long-term predictors for the short-term disease course. It emphasizes the need for further development of simple clinical tools or biomarkers for early patient stratification.

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Barrow, M. V. "Mr. Jefferson and the Giant Moose: Natural History in Early America. By Lee Alan Dugatkin. (Chicago: University of Chicago Press, 2009. xii, 166 pp. $26.00, ISBN 978-0-226-16914-9.)". Journal of American History 97, n.º 2 (1 de setembro de 2010): 502–3. http://dx.doi.org/10.1093/jahist/97.2.502.

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Gerçek, Muhammed, Anca A. Irimie, Mustafa Gerçek, Henrik Fox, Vera Fortmeier, Tanja K. Rudolph, Volker Rudolph e Kai P. Friedrichs. "Dynamics of Cognitive Function in Patients with Heart Failure Following Transcatheter Mitral Valve Repair". Journal of Clinical Medicine 11, n.º 14 (9 de julho de 2022): 3990. http://dx.doi.org/10.3390/jcm11143990.

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Aims: Interventional transcatheter edge-to-edge mitral valve repair (TMVR) is an established treatment option for patients with severe mitral regurgitation (MR) and high operative risk. Cognitive impairment is one of the most common conditions among often extensive comorbidities in these patients. The specific patterns of cognitive decline and particularly the effect of TMVR are not well described. Thus, this study aimed to investigate into the impact of TMVR on cognitive impairment, exercise capacity, and quality of life. Methods: Cognitive function (executive, naming, memory, attention, language, abstraction, and orientation) was assessed with the standardized Montreal Cognitive Assessment test (MoCA; range between 0 and 30 points) before and 3 months after TMVR in 72 consecutive patients alongside echocardiographic examination and assessment of exercise capacity (six-minute walk test) as well as quality-of-life questionnaires (Minnesota living with heart failure questionnaire, MLHF-Q). Results: Patients’ median age was 81 [76.0; 84.5] years, 39.7% were female with a median EuroScore II of 4.4% [2.9; 7.7]. The assessment of cognitive function showed a significant improvement of the cumulative MoCA-Test result (from 22.0 [19.0; 24.5] to 24 [22.0; 26.0]; p < 0.001) with significant changes in the subcategories executive (p < 0.001), attention (p < 0.001), abstraction (p < 0.001), and memory (p < 0.001). In addition, quality of life (from 47.5 [25.0; 69.3] to 24.0 [12.0; 40.0]; p < 0.001) and exercise capacity (from 220.0 m [160.0; 320.0] to 280.0 m [200.0; 380.0]; p = 0.003) increased significantly 3 months after the TMVR procedure. Conclusions: TMVR leads to a significant improvement of cognitive function, exercise capacity, and quality of life in patients with chronic heart failure in 3 months follow up and again highlights the benefit of the evermore established TMVR procedure for patients with high operative risk.

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Ahmad, Muhammad Ramli, Muhammad Wirawan Harahap e Nur Surya Wirawan. "Comparative effect of preoperative oral pregabalin 50 mg vs. 75 mg on nerve growth factor (NGF) levels in parturients undergoing cesarean section". Anaesthesia, Pain & Intensive Care 27, n.º 6 (12 de dezembro de 2023): 721–25. http://dx.doi.org/10.35975/apic.v27i6.2159.

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Background & objectives: Postoperative pain after cesarean section (CS) is a crucial problem faced by the parturients. Pregabalin is a choice of preventive analgesia to reduce neuropathic pain, inflammation, tissue irritation, and post-cesarean section pain. The purpose of this study was to compare the effect of giving pregabalin 50 mg or 75 mg in combination with paracetamol 1 g on nerve growth factor (NGF) levels after cesarean section. Methodology: A prospective, comparative model was used in this study. The study took place at Mother and Children Hospital of Sitti Khadijah I, Makassar, Indonesia. A total of 30 patients who underwent CS were randomly divided into two groups; group P1 who received pregabalin 50 mg orally and 1 g paracetamol intravenously, 1 h before surgery (n = 15), and group P2 who received pregabalin 75 mg orally and 1 g paracetamol intravenously, 1 h before surgery (n = 15). Nerve Growth Factor (NGF) levels were measured 2 h before surgery, and at 4 and 6 h post-surgery. Data were analyzed by the Mann-Whitney test using SPSS 26.0. Results: There was a decrease in NGF levels in the pregabalin 75 mg group at 6 h post-surgery, while in the pregabalin 50 mg group it tended to increase at 4 and 6 h post-surgery. In the pregabalin 50 mg group, there was a significant increase in NGF levels from measurements of NGF1 to NGF2 and NGF0 to NGF2 (P < 0.05), whereas, in the pregabalin 75 mg group, there was a significant decrease in NGF levels from measurements of NGF1 to NGF2 and NGF0 to NGF2 (P < 0.05). Conclusion: The combination of pregabalin 75 mg orally with paracetamol 1 g intravenously is effective as perioperative multimodal analgesia by reducing nerve growth factor levels after cesarean section surgery. Abbreviations: BDNF- brain-derived neurotrophic factor; CS- Cesarean section; GABA- Gamma Amino Butyric Acid; NGF- Nerve Growth Factor Keywords: Cesarean section; Nerve Growth Factor (NGF); Postoperative; Pregabalin Citation: Ahmad MR, Harahap MW, Wirawan NS. Comparison between pregabalin 50 mg and 75 mg on nerve growth factor (NGF) levels after cesarean section. Anaesth. pain intensive care 2022;27(6):721−725; DOI: 10.35975/apic.v27i6.2159 Received: February 20, 2923; Revised: July 11,2023; Accepted: October 29, 2023

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Sun, Shibin, e Ali Liu. "Long-term follow-up studies of Gamma Knife surgery for patients with neurofibromatosis Type 2". Journal of Neurosurgery 121, Suppl_2 (dezembro de 2014): 143–49. http://dx.doi.org/10.3171/2014.8.gks141503.

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ObjectThe aim of this study was to evaluate long-term clinical outcomes after Gamma Knife surgery (GKS) for patients with neurofibromatosis Type 2 (NF2) and the role of GKS in the management of NF2.MethodsFrom December 1994 through December 2008, a total of 46 patients (21 male, 25 female) with NF2 underwent GKS and follow-up evaluation for at least 5 years at the Gamma Knife Center of the Beijing Neurosurgical Institute. GKS was performed using the Leksell Gamma Knife Models B and C. The mean age of the patients was 30 years (range 13–59 years). A family history of NF2 was found for 9 (20%) patients. The NF2 phenotype was thought to be Wishart for 20 (44%) and Feiling-Gardner for 26 (56%) patients. Among these 46 patients, GKS was performed to treat 195 tumors (73 vestibular schwannomas and 122 other tumors including other schwannomas and meningiomas). For vestibular schwannomas, the mean volume was 5.1 cm3 (median 3.6 cm3, range 0.3–27.3 cm3), the mean margin dose was 12.9 Gy (range 10–14 Gy), and the mean maximum dose was 27.3 Gy (range 16.2–40 Gy). For other tumors, the mean volume was 1.7 cm3 (range 0.3–5.5 cm3), the mean margin dose was 13.3 Gy (range 11–14 Gy), and the mean maximum dose was 26.0 Gy (range 18.0–30.4 Gy). The median duration of follow-up was 109 months (range 8–195 months).ResultsFor the 73 vestibular schwannomas that underwent GKS, the latest follow-up MR images demonstrated regression of 30 (41%) tumors, stable size for 31 (43%) tumors, and enlargement of 12 (16%) tumors. The total rate of tumor control for bilateral vestibular schwannomas in patients with NF2 was 84%. Of the 122 other types of tumors that underwent GKS, 103 (85%) showed no tumor enlargement. The rate of serviceable hearing preservation after GKS was 31.9% (15/47). The actuarial rates for hearing preservation at 3 years, 5 years, 10 years, and 15 years were 98%, 93%, 44%, and 17%, respectively. Of the 46 patients, 22 (48%) became completely bilaterally deaf, 17 (37%) retained unilateral serviceable hearing, and 7 (15%) retained bilateral serviceable hearing. The mean history of the disease course was 12 years (range 5–38 years).ConclusionsGKS was confirmed to provide long-term local tumor control for small- to medium-sized vestibular schwannomas and other types of tumors, although vestibular schwannomas in patients with NF2 responded less well than did unilateral sporadic vestibular schwannomas. Phenotype is the most strongly predictive factor of final outcome after GKS for patients with NF2. The risk for loss of hearing is high, whereas the risk for other cranial nerve complications is low.

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Vaswani, Ravi S., Andrew J. Sheean, Gregory Gasbarro, Christopher John Como, Kevin Kohut, Mitchell Stephen Fourman, Andrew Wilmot, Camilo Borrero, Dharmesh Vyas e Albert Lin. "Variations In Glenoid Bony Morphology May Predict Recurrent Instability After Arthroscopic Bankart Repair". Orthopaedic Journal of Sports Medicine 8, n.º 3_suppl2 (1 de março de 2020): 2325967120S0012. http://dx.doi.org/10.1177/2325967120s00121.

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Objectives: Variations in bony anatomy may be a significant risk factor for failure of stabilization surgery and could help explain the etiology of recurrent dislocations. Identifying these variations may help guide surgical decision making. The aim of this study was to develop a method to quantify bony morphology and measure glenoid and humeral head volume on MRI to identify risk factors for failure after Bankart repair. We hypothesized that the ratio of humeral head to glenoid volume and a shallower glenoid socket or greater radius of curvature would be significant risk factors in patients who failed stabilization surgery. Methods: This was a retrospective case-control study of 289 patients from 2005-2015. Inclusion criteria were primary anterior arthroscopic shoulder stabilization, no prior shoulder surgery, and traumatic etiology. Exclusion criteria were posterior labral pathology, multidirectional instability, connective tissue disorder, or concomitant rotator cuff pathology. Surgical failure was defined as a redislocation event and these cases were compared 1:2 to an age- and sex-matched control without recurrent instability. Demographic data was obtained by chart review. Pre-operative MR arthrograms were analyzed by two trained reviewers. Vitrea software (Vital Images, Minnetonka, MN) was utilized to measure the volume and radius of curvature of both the humeral head (Figure 1) and glenoid on T1 sequences. A larger radius of curvature corresponded to an overall shallower glenoid socket. Fisher exact and the student t test were used for statistical analysis with significant defined as p < 0.05. Results: Ninety-five patients met the inclusion criteria, 36 of whom were in the case group, with an average follow-up of 30.3 months. There was no difference between groups with regard to baseline demographic and radiographic parameters (Table 1). The average number of preoperative dislocations was significantly higher in the failure group (3.13 vs. 1.91, p < 0.05). The humeral head (67.8 ml vs 62.3 ml, p =0.13) and glenoid volume (13.7 ml vs 13.0 ml, p=0.42) were similar between the two groups, as was the ratio of the two (5.1 vs 4.9, p=0.30). The radius of curvature of the glenoid was slightly larger, or shallower, in the case group compared to the control group (23.8 mm vs 22.6 mm, p=0.02). The ratio of the radius of curvature of the humeral head to the glenoid was similar between the two groups (1.1 vs 1.1, p=0.11). Further analysis demonstrated that a greater portion of patients with a glenoid radius of curvature greater than 24.5 experienced a postoperative dislocation compared to those who had a smaller radius of curvature (63.6% vs 26.0%, p < 0.01) (Table 1). There was no significant difference between the number of preoperative dislocations between patients with larger or smaller glenoid radius of curvature (2.7 vs 2.3, p = 0.57). Conclusion: Using a novel method of quantifying the bony morphology, our results demonstrate that a larger radius of curvature, particularly greater than 24.5 mm, which is indicative of a shallower glenoid, may predispose patients to failure following a primary arthroscopic Bankart. These findings suggest that the overall bony concavity of the glenoid may play an inherent role regarding stability. [Table: see text]

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