Literatura científica selecionada sobre o tema "Modeling of AR-XPS intensity"

This study predicts how the Free Surface Level (FSL) variations around finite length vegetation affect flow structure by using a numerical simulation. The volume of fluid (VOF) technique with the Reynolds stress model (RSM) was used for the simulation. Multizone Hexahedral meshing was adopted to accurately track the free surface level with minimum numerical diffusion at the water–air interface. After the validation, finite length emergent vegetation patches were selected based on the aspect ratio (AR = vegetation width-length ratio) under constant subcritical flow conditions for an inland tsunami flow. The results showed that the generation of large vortices was predominated in wider vegetation patches (AR > 1) due to the increase and decrease in the FSL at the front and back of the vegetation compared to longer vegetation patches (AR ≤ 1), as this offered more resistance against the approaching flow. The wider vegetation patches (AR > 1) are favorable in terms of generating a large area of low velocity compared to the longer vegetation patch (AR < 1) directly downstream of the vegetation patch. On the other hand, it has a negative impact on the adjacent downstream gap region, where a 14.3–34.9% increase in velocity was observed. The longer vegetation patches (AR < 1) generate optimal conditions within the vegetation region due to great velocity reduction. Moreover, in all the AR vegetation cases, the water turbulent intensity was maximum in the vegetation region compared to the adjacent gap region and air turbulent intensity above the FSL, suggesting strong air entrainment over this region. The results of this study are important in constructing vegetation layouts based on the AR of the vegetation for tsunami mitigation.

AbstractThe influence of plasma shielding effect induced by ambient gas pressure and laser intensity on the laser-produced Cu plasma parameters, signal-to-background ratio (S/B) and expansion are experimentally and numerically investigated. A Q-switched Nd:YAG laser at 1064 nm at various intensities ranging from 2 to 7.1 GW/cm2 intensity (40–150 mJ) is used to produce Cu plasma in air, argon (Ar), helium (He), and neon (Ne) ambient gas at various pressures ranging from 5 to 1000 mbar. Laser-induced breakdown spectroscopy reveals that spectral radiation, S/B, electron temperature, number density, and front edge velocity of the plasma have an increasing trend up to a certain value of laser intensity and gas pressure. Afterwards, a saturation trend is achieved, which is attributed to the shielding and self-regulation effect. The numerical modeling of the laser-produced Cu plasma in the presence of air at atmospheric pressure is carried out using the MULTI radiation hydrodynamics code. We have shown that the feature of plasma shielding effect observed in the experiments can be reproduced using a continuum hydrodynamics model. Laser intensity at about 3.5 GW/cm2 is found to produce the highest S/B at 1000 mbar air. He, Ne, air, and Ar show the best S/B, respectively and the best S/B is found for air, Ar, He, and Ne at 10, 5, 10, and 20 mbar, respectively. The expansion of plasma plume is studied using a simple and effective technique based on probe laser absorption and scattering method. The plasma plume expansion through He, Ne, air, and Ar at 1000 mbar pressure has the highest velocity, respectively. The simulated results of strong shock wave model and Rankine–Hugoniot jump condition are fitted to the experimental data, which are then used to estimate the values of the ablation parameters.

Historical farm ponds have been designed, maintained, and established as heritage sites or cultural landscapes. Has their gradually evolving function resulted in changes to the landscape influenced by their degenerated nature and the new urban fabric? This study aimed to assess the interaction between urban fabrics and eight farm ponds in Taoyuan by determining the demolition ratio of ponds subject to the transit-oriented development (TOD) of infrastructure and to evaluate land cover using historical maps, unmanned aerial vehicle (UAV)-assisted 3D modeling, smartphone augmented reality (AR), and a gaming engine to inspect and compare well-developed or reactivated ponds and peripheries. A 46% reduction in pond area around Daxi Interchange was an important indicator of degeneration in the opposite direction to TOD-based instrumentation. Three-dimensional skyline analysis enabled us to create an urban context matrix to be used in the simulations. Nearly 55 paired AR comparisons were made with 100 AR cloud-accessed models from the Augment® platform, and we produced a customized interface to align ponds with landmark construction or other ponds using Unreal Engine®. Smartphone AR is a valuable tool for situated comparisons and was used to conduct analyses across nine categories, from buildings and infrastructure to the intensity and stage of development. The gaming engine handled large point models with high detail and was supported by a customized blueprint. We found that 3D virtual dynamics highlighted the evolving interstitial space and role substitution of the agricultural fabric. This combination of heterogeneous platforms provides a practical method of preserving heritage and enables conflict resolution through policy and TOD instrumentation.

This article presents the results of computer modeling of small-angle scattering of Ar+ ions from the surface of the SiO2 thin film under bombardment by low-energy. The study of the trajectory of the scattered ions showed that the trajectories with two focuses are observed not only near the center of the semichannel but also nearby the surface of the atomic chain. An increase in the value of the initial energy of incident particles leads to a narrowing of the trajectory of the scattered ions, which leads to the appearance of low-intensity peaks in the energy spectrum of the scattered ions.

Background The time course of rhinovirus positive and negative rhinosinusitis has not been quantified yet, which aggravates proper selection and justification of the optimum treatment for this illness. Such quantitative information would facilitate an early and proper identification of the disease and its differentiation from acute bacterial rhinosinusitis, and could diminish harmful overuse of antibiotics, arguably driven by patients’ want for attention and the treating physicians’ inability to offer an adequate verbal comfort in its stead. Objective Extraction of the quantitative information needed to identify rhinovirus positive or negative rhinosinusitis and to allow selection of the most appropriate treatment from the published time dependence of individual clinical symptoms of the disease. Methods Scrutiny (and modeling) of temporal evolution of all noteworthy symptoms of rhinosinusitis with a simple mathematical expression that relies on two adjustable parameters per symptom (and potentially a general time offset as an extra adjustable parameter). Results Adverse effects of rhinosinusitis can be grouped according to the sequence of their exponential appearance and ~2.6 times slower exponential disappearance, rhinovirus negative rhinosinusitis generally improving ~25% faster and being ~40% less severe. The major early local symptoms (throat soreness and scratchiness, headache) vanish with a half-life of ~1.8 days, whereas further local symptoms take ~1.6 times longer to disappear. At least 50–60% improvement of two prominent early symptoms, sore throat and sneezing (but not of nasal discharge, cough, and hoarseness) by day 5 of the disease implies a nonbacterial origin of rhinitis and should exclude use of antibiotics. Conclusion Temporal evolution of all rhinosinusitis symptoms is qualitatively similar, which makes the early symptom decay a good proxy for, and predictor of, the disease perspective. Knowing a symptom intensity at just three to four time points suffices for reconstructing its entire time course and total intensity or gravity. This permits an easy and early identification of rhinosinusitis, and its plausible differentiation from acute bacterial rhinosinusitis, disease treatment optimization, and corresponding clinical trials simplification and/or shortening.

Abstract Prostate cancer (PC) stands as the most frequently diagnosed and second leading cause of cancer death among American men. PC mortality is predominantly attributed to castration-resistant prostate cancer (CRPC), often emerging within 2-3 years following the initiation of androgen deprivation therapy. This resistance primarily arises from sustained androgen receptor (AR) signaling, ultimately resulting in a compromised response to AR-directed therapies. AR splice variant expression is a key contributor to the persistent AR signaling in CRPC. AR-variant 7 (AR-V7) is the most clinically prevalent variant, expressed in about 75% of patients with CRPC and confers resistance to standard of care (SoC) treatments. AR-V7 differs from the full-length AR (AR-fl) because it lacks the ligand binding and hinge domains, rendering it resistant to SoC treatments. Currently, there are no selective inhibitors for AR-V7. Therefore, we sought to identify unique biological features of AR-V7, distinct from AR-fl, to exploit therapeutic options for targeting AR-V7. Previous studies have demonstrated high sequence homology, largely overlapping cistromes, and gene transactivation profiles between AR-V7 and AR-FL. Our published mechanistic studies revealed that AR-V7 utilizes a unique nuclear import pathway, not shared by AR-fl, allowing for constitutive import and activation of target genes in the nucleus. Herein, we report an additional novel subnuclear phenotype of AR-V7 in LNCAP95 and 22RV1 cells modeling CRPC. Staining with AR-V7- and AR-fl- specific antibodies revealed that unlike AR-fl, AR-V7 exhibited prominent nucleolar localization. To validate AR-V7 nucleolar localization, CRPC cells stained with fibrillarin (nucleolar marker), and subsequent fluorescence intensity analysis revealed that AR-V7 was predominantly localized in fibrillarin positive nucleoli, whereas AR-fl protein was solely localized in the nucleoplasm. This suggests a novel functional role of AR-V7 in the nucleus. To further confirm AR-V7 nucleolar localization, Actinomycin D (ActD) was used as a tool compound to disrupt nucleolar integrity. Treatment with ActD for 4 hours in CRPC cells significantly reduced the area of fibrillarin positive nucleoli and prompted AR-V7 re-distribution out of the nucleoli and into the nucleoplasm. Ongoing efforts to further investigate AR-V7 nucleolar function in CRPC cells include mutating the predicted nucleolar localization signal located in AR-V7 and identifying nucleolar-interacting proteins through proximity-labeling assays. In conclusion, we unveiled a novel nuclear compartmentalization of AR-V7 within the nucleolus, the primary hub for ribosomal biogenesis. These observations suggest that AR-V7 could regulate the high levels of protein synthesis occurring in CRPC cells, creating a window of a potential therapeutic opportunity for selective inhibition. Citation Format: Michelle K. Naidoo, Paraskevi Giannakakou. Novel insights into androgen receptor-variant 7 subnuclear localization and function in castration resistant prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6271.

The parameters of the gas phase and the kinetics of reactive ion etching of SiO2 and Si3N4 under conditions of an induction RF (13.56 MHz) discharge with a varying HBr/Cl2 ratio is studied. The study includes plasma diagnostics using Langmuir probes, plasma modeling to find stationary concentrations of active particles, measuring velocities, and analyzing etching mechanisms in the effective interaction prob-ability approximation. It is found that the substitution of HBr by Cl2 at a constant argon content (a) is accompanied by a noticeable change in the electrical parameters of the plasma; (b) leads to a weak increase in the intensity of ion bombardment of the treated surface; and (c) causes a significant increase in the total concentration and flux density of reactive particles. It is shown that the etching rates of SiO2 and Si3N4 increase monotonically as the proportion of Cl2 increases in a mixture, while the main etching mechanism is an ion-stimulated chemical reaction. The model description of the kinetics of such a reaction in the first approximation assumes (a) the additive contribution of bromine and chlorine atoms and (b) the direct pro-portional dependence of their effective interaction probabilities on the intensity of ion bombardment. The existence of an additional channel of heterogeneous interaction with the participation of HCl molecules is proposed.

This paper reports the geometrical characteristics and the growth of aggregate silica particles generated in a premixed flame using thermophoretic sampling, a light scattering technique, and aggregate dynamics modeling only for a premixed flat flame condition. The area equivalent size and the morphology of thermophoretically collected silica aggregate particles were analyzed through images taken from a transmission electron microscope. The particle stream in flames was visualized through a planar light scattering technique. Light scattering intensity at 90° using an Ar-ion laser (wavelength, 514 nm) was monitored for various flame conditions. The results of aggregate dynamics modeling under a one-dimensional assumption indicated that the silica particles grew as the height above the burner increased. Aggregate particles produced at various equivalence ratios showed different levels of OH-species. The OH-related species increased as the equivalence ratio decreased, which implies that a high equivalence ratio is recommended to produce pure silica particles. In this study, the purest silica aggregate particles were produced at the equivalence ratio of 11.4, among others. Our study helps to determine which flame condition is best in terms of the quality and/or quantity of silica aggregate particles generated by a coflow burner.

Background Active rehabilitation involving subsymptom threshold exercise combined with education and support promotes recovery in youth with concussion but is typically delivered in person, which may limit accessibility for families because of a lack of services in their communities or logistical challenges to attending in-person sessions. Objective This paper describes the evidence-based and theory-informed development of the Tele-Active Rehabilitation (Tele-AR) intervention for pediatric concussion, which was specifically designed for remote service delivery. Methods The intervention was designed by clinician-researchers with experience in pediatric concussion rehabilitation following the Medical Research Council guidance for developing complex interventions. Development involved a critical review of the literature to identify existing evidence, the expansion of the theoretical basis for active rehabilitation, and the modeling of the intervention process and outcomes. Results Tele-AR is a 6-week home exercise and education and support program facilitated through weekly videoconferencing appointments with a clinician. Exercise consists of low- to moderate-intensity subsymptom threshold aerobic activity and coordination drills that are individualized to participant needs and interests (prescribed for 3 days per week). Education includes the evidence-supported Concussion & You self-management program, which covers topics related to energy management, nutrition, hydration, sleep hygiene, and return to activity. Elements of self-determination theory are incorporated to support motivation and engagement. We present a logic model describing predicted intervention effects using a biopsychosocial conceptualization of outcomes after concussion. Conclusions The Tele-AR intervention may help to increase access to care that improves recovery and promotes a timely return to activity in youth with concussion. Future research is needed to evaluate the feasibility and efficacy of this approach.

Aims. In this paper, we report multiwavelength observations of remote coronal dimmings related to an M1.1 circular-ribbon flare in active region (AR) 12434. Methods. The confined flare without a coronal mass ejection was observed by the Atmospheric Imaging Assembly (AIA) and the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory on 2015 October 16. We obtained global three-dimensional (3D) magnetic fields before the flare using the potential field source surface modeling. Results. A few minutes before the flare hard X-ray peak time (06:13:48 UT), small-scale, weak dimming appeared ∼240″ away from the flare site, which can be observed by AIA only in 131 and 171 Å. Afterward, long and narrow dimmings became evident in all AIA extreme-ultraviolet passbands except 304 Å, while localized core dimming was not clearly observed near the flare site. The large-area dimmings extended southeastward and the areas increased gradually. The total area of dimmings reaches (1.2 ± 0.4) × 104 Mm2 in 193 Å. The maximal relative intensity decreases in 171 and 193 Å reach 90% and 80%, respectively. Subsequently, the dimmings began to replenish and the area decreased slowly, lasting for ≥3 h. The remote dimmings and AR 12434 are connected by large-scale coronal loops. The remote dimmings are associated with the southwest footpoints of coronal loops with weak negative polarities. Possible origins of remote dimmings are discussed.

Die Nutzung von terrestrischen Ökosystemen zur Befriedigung der Grundbedürfnisse der Menschheit hat tiefgreifende Auswirkungen auf das Erdsystem und führte zur Ausprägung von anthropogen dominierten Landsystemen. Diese sind von hoher Komplexität, da sie aus einer Vielzahl von unterschiedlichsten Einflussfaktoren angetriebenen Landnutzungsveränderungen hervorgegangen sind. Aktuelle Forderungen nach einer nachhaltigen zukünftigen Landnutzung erfordern ein fundiertes und integratives Verständnis dieser Komplexität. Das Hauptziel dieser Arbeit ist es, ein besseres Verständnis der raum-zeitlichen Muster und Determinanten des Landsystemwandels, insbesondere der Landnutzungsintensität, in Europa zwischen 1990 und 2010 zu erlangen. Europa ist ein interessantes Studiengebiet, da es jüngst starke Landnutzungsveränderungen erlebte und seine Heterogenität zu einer Vielfalt von Landsystemen und Landsystemveränderungen führte. Das Ziel der Arbeit wurde durch (i) die Kartierung von Intensitätsmustern und deren Veränderungen in Forst- und Agrarsystemen sowie der Ermittlung der dafür einflussreichsten räumlichen Determinanten und (ii) die Kartierung und Charakterisierung archetypischer Muster und Entwicklungsverläufe von Landsystemen untersucht. Die Ergebnisse dieser Arbeit zeigten einen deutlichen Ost-West-Unterschied in Landsystemmustern und -veränderungen in Europa, mit intensiv genutzten und intensivierenden Regionen vor allem in Westeuropa. Dennoch wurde Europa vor allem durch relativ stabile Landsystemmuster gekennzeichnet und (De-)Intensivierungstrends waren nur von untergeordneter Bedeutung. Intensitätsmuster und -veränderungen waren stark an Standortbedingungen gebunden, vor allem an edaphische, klimatische, und länderspezifische Besonderheiten. Diese Arbeit erweitert das Verständnis des Landsystemwandels in Europa und kann zur Entwicklung wissenschaftlicher und politikbezogener Maßnahmen sowie zur Erreichung einer nachhaltigeren Landnutzung in Europa beitragen.
The utilisation of terrestrial ecosystems to satisfy the basic needs of humankind has profound impacts on the Earth System and led to the development of human-dominated land systems. These are substantially complex as they evolved from a multitude of land-change pathways driven by a variety of influential factors. Current calls for a more sustainable future land-use require a sound and integrative understanding of this complexity. The main goal of this thesis is to better understand the spatio-temporal patterns and the determinants of land-system change in Europe between 1990 and 2010, especially with regard to land-use intensity. Europe serves as an interesting study region as it recently experienced a period of marked land-use change, and since its large environmental, political, and socio-economic heterogeneity resulted in a diversity of land systems and land-change pathways. Land-system changes in Europe were examined by (i) mapping patterns and changes in forestry and agricultural intensity and identifying the most influential spatial determinants related to these changes, and (ii) mapping and characterising archetypical patterns and trajectories of land systems considering both land-use extent and intensity indicators. Results revealed a distinct east-west divide in Europe’s land-system patterns and change trajectories, with intensively used and intensifying regions particularly located in Western Europe. However, Europe was mainly characterised by relatively stable land-systems patterns with (de-) intensification trends being only of minor importance. Land-use intensity levels and changes were strongly related to site conditions, especially with regard to soil and climate, as well as to country-specific characteristics. By fostering the understanding of land-system change, this thesis has the potential to contribute to scientific and policy-related actions that address current efforts to guide future land systems in Europe to a more sustainable use.

AbstractIn order to successfully steer a ship, a man, ship’s watch officer, or commander of the ship must be physically ready and must know the maneuvering characteristics of the ship he steers, as well as the forces acting on him. For that, it is necessary for him to know the specifics of the ship because each ship has its own "mood", its specific properties that depend on the type, and size of the ship. Therefore, maneuvering properties differ even in ships of the same type and therefore it is important to know the specifics of a particular ship. Also, the same ship will behave differently in different situations. When the ship finds itself in situations that require urgent reaction during the voyage, then the experience and skills of the ship's captain come to the fore. Then it is important that the captain, based on his experience, chooses the right maneuver, but also that he always has at least one reserve maneuver in his head. That decision in certain situations must be made in a very short period of time, and the future of the ship and human lives often depends on it, as well as the resources on board. Every skill is acquired through practice, and it is logical that the commander will react faster and more correctly in every new situation. Precisely because of this, the most intensive training is necessary for the formation of quality ship commanders. For that reason, the training of future ship commanders on ship simulators gives excellent results. On ship simulators, they can gain a lot of experience and go through countless scenarios. In this paper, the use-value of ship simulators from the aspect of the training was verified through the Search and Rescue (SAR) exercise realized on the ship simulator Wärtsilä Navigation Simulator NTPRO 5000. It has been shown that the simulator can successfully check and recognize the optimal SAR pattern, maneuvering characteristics of the ship, as well as practice, maneuvering the ship and resolving specific situations that ship commanders may encounter in real situations. Training on ship simulators cannot completely replace training in real situations, but it can be used to get acquainted with the maneuvering characteristics of the ship, train in working with navigation devices, and be a good starting point in preparing people who are trained to perform tasks in real situations. The use of hydrological data of relationships between different types of data using an autoregressive model (AR model) can contribute to the creation of more realistic scenarios on ship simulators. It is also possible to apply data in the modeling of the environment and connect them with the current hydrological situation of the waterway. In the exercise evaluation process, we can see if the ship's captain used the hydrological data in the right way.

ZnO is a well-known traditional industrial material which has high potential to become one of the key components for the next generation of future electronics, LED emitters, visible light photocatalysis and others. In its pristine form ZnO has relatively wide band gap of approximately 3.4 eV, but a lot of emerging applications requires some level of electronic structure engineering and structure optimisation. Studies show that ZnO properties strongly depend on the intrinsic defects type and concentrations. Both characteristics usually are depending on the synthesis method. Accordingly, there is great interest to develop new methods which would allow to obtain ZnO with optimised band gap and other properties. In current, study ZnO films were deposited using reactive magnetron sputtering with unconventional Ar-O2 gas mixture supply control: Ar flow was controlled to maintain total gas pressure at 1x10-2 mbar, whereas O2 flow rate was actively adjusted to maintain the selected intensity of optical zinc emission from the working cathode zone. Applying such ZnO formation method it was possible to stabilise reactive magnetron sputtering process over wide range of conditions. Elemental composition analysis by XPS revealed that despite large variations in Zn emission peak intensity within tested experimental conditions all films had nearly identical Zn:O ratios but at the same time their structural and optical properties differed significantly. The colour of the films varied from highly transparent yellowish-greenish, to intense orange, to opaque black. XRD analysis showed that films consisted of single polycrystalline wurtzite phase with varying orientations. PL spectroscopy analysis revealed that films had a lot of various defects including oxygen and zinc vacancies, interstitials and surface defects. Wide variation of ZnO properties obtained by different reactive sputtering conditions demonstrates the potential of the proposed method to control the formation of various intrinsic defects and to tailor their concentration.