Teses / dissertações sobre o tema "Méthodologie RMN"
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Bourgeois, Dominique. "Méthodologie en imagerie RMN : imagerie haute résolution, imagerie spectroscopique, imagerie de débits". Université Joseph Fourier (Grenoble), 1990. http://www.theses.fr/1990GRE19005.
Texto completo da fonteBaguet, Évelyne. "Renouvellement de l'ATP dans la cellule végétale : méthodologie du transfert de saturation en RMN 31P". Grenoble 1, 1994. http://www.theses.fr/1994GRE10002.
Texto completo da fonteSabbah, Maher. "Méthodologie pour la synchronisation cardiaque et respiratoire : application à l'imagerie RMN haute résolution chez le petit animal". Compiègne, 2006. http://www.theses.fr/2006COMP1614.
Texto completo da fonteDouble cardiac and respiratory gating methods help to follow the progression of the disease of transgenic mice's vessel wall using cardiovascular MRI, which is limited by motion artefacts and anatomical small sized structures. Such experiments are affected by the hostile MR environment and require appropriate signal processing and correct QRS detection, but gating software methods are currently limited. We have developed digital real-time gating model which allowed that high-resolution MR images of mouse hearts and aortic arches could acquired using a chain consisting of ECG signal detection, digital signal processing and acquisition window generation. Three signal processing techniques were validated by simulation, then in real time during unique cardiac gating; furthermore a processing/detection method was optimized with respect to ECG signal SNR increasing and R waves detection's precision rates. Finally, the method efficiency was proved using double gating, using pressure transducer or ECG amplitude demodulation, and contrast enhancement of the carotid wall was evaluated. Ln further studiers, the graphical user interface tool that managed the three real time gating strategies will be applied to molecular imaging of atherosclerosis lesions in mice and associated to an large band ECG amplifier in order to clearly define subject's physiopathology state
Bordelois, Boizán Alejandro. "Développements de méthodes d'acquisition et de traitement du signal robustes aux défauts du champ magnétique pour la spectroscopie localisée par RMN". Phd thesis, Université Rennes 1, 2013. http://tel.archives-ouvertes.fr/tel-00914306.
Texto completo da fonteKienlin, Markus von. "Instrumentation et méthodologie en spectroscopie RMN du proton in vivo : suppression de l'eau, édition de spectre, localisation spatiale". Grenoble INPG, 1988. http://www.theses.fr/1988INPG0071.
Texto completo da fonteShintu, Laetitia. "Développement d’une méthodologie combinée RMN Haute Résolution à Rotation à l’Angle Magique (HRMAS) et chimiométrie pour l’étude de produits alimentaires". Aix-Marseille 3, 2006. http://www.theses.fr/2006AIX30020.
Texto completo da fonteIn order to determine the authenticity of food materials, several analytical techniques (HPLC, MS, liquid-state NMR) are traditionally employed. These techniques are all the more efficient since the analyzed substances are homogeneous. However, many foods being neither liquid nor solid, it is necessary to carry out some extractions which may deteriorate them. This thesis reports the potential of High Resolution Magic Angle Spinning NMR (HRMAS) for the study of some raw food materials (cheese and meat) allowing for the assignment of the majority of 1H signals as well as the exploitation of the information contained in their 1H HRMAS spectra by multivariate statistical analyses (PCA, DA, PLS-DA) in order to extract from them quality or origin markers. The HRMAS/Chemometrics method enabled the characterization of Parmigiano Reggiano cheese according to its age of ripening, and the Emmental cheese and dried beef meat according to their geographical origin
Gaubert, Alexandra. "Vers une méthodologie de la déformulation des mélanges complexes combinant outils analytiques et chimiométriques : apllication aux détergents". Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10241.
Texto completo da fonteDeformulation of complex mixtures requires analytical methods for compound identification and quantification. It still represents a real analytical challenge in various industrial fields, such as cosmetics, health, food, materials. In this context, we studied complex mixtures such as detergents and especially, laundry detergents, that represent a constantly growing market. Regulations becoming stricter and consumers requiring more eco-friendly products, manufacturers constantly innove detergent formulations by using bio-based surfactants or enzymes. Laundry detergents containing up to 25 compounds, we focused on the analysis of their major components, i.e. surfactants and enzymes. After developing a comprehensive sample library of such raw materials, 1H NMR and Raman spectrometry were used for surfactant identification and quantification while Isotope Ratio Mass Spectrometry (IRMS) was tested to evaluate their bio-sourced origin. Raman spectrometry combined with chemometric tools such as signal extraction methods was useful for surfactant identification and quantification. Enzymes were identified and quantified using protein precipitation before analyses by LCMS/ MS. All these analytical developments contribute to the establishment of a deformulation strategy for detergent products
Ince, Ridvan. "Étude du magnétisme moléculaire local par RMN des solides paramagnétiques à haute résolution". Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0206.
Texto completo da fonteThe purpose of this work is to try and set up a new tool for the experimental determination of local magnetic susceptibility tensor. We have worked on an isotructural series of lanthanide oxalate [Ln2(C2O4)3, 9,5H2O] with Ln = La, Ce, Pr, Nd, using NMR of the paramagnetic solid in order to show thefeasability of this kind of studies by solid-state NMR.To determine the local magnetic susceptibility, we propose a semi-empirical approach based on a parameterized point dipole model for local magnetism. The model is based on the knowledge of the crystal structure and the empirical approximation of the point dipole for each paramagnetic center in the structure. The hyperfine dipole interaction is calculated for each NMR observable nucleus by summing the effect of each paramagnetic center on the NMR spectrum within the radius of convergence of our model. The resulting spectrum is then compared to the experimental data and the model parameters are optimized to obtain the best fit.The fact that this semi-empirical model is very fast to calculate opens a wide panel of accessible measurements through this method. For instance, we were able to perform a statistical analysis of each parameter of the local magnetic susceptibility tensor.We have compared our results with SQUID measurements of the macroscopic susceptibility and it showed a good agreement between the isotropic component obtained by both measurements.We explored several possibilities offered by this method in order to access the diamagnetic components of the chemical shift tensor by changing the temperature of our samples. We also tried to push ourstudies towards disordered systems for which diffraction methods have more difficulties to access local magnetic informations
Gaillard, Eric. "Méthodologie en spectroscopie par résonance magnétique nucléaire avec un aimant résistif de 1. 2 T : application aux traitements des données RMN et à la spectroscopie 1H haute résolution". Lyon 1, 1991. http://www.theses.fr/1991LYO1T078.
Texto completo da fonteZiani, Latifa. "Développement de diverses méthodologies RMN en milieu cristal liquide chiral". Paris 11, 2008. http://www.theses.fr/2008PA112036.
Texto completo da fonteThe aim of this thesis is the development of the NMR by using a chiral liquid crystal as solvent. In a first part, new 2D NMR experiments are described to simplify the proton and carbon-13 spectra. Thus we can easily measure the dipolar couplings and visualize the enantiomeric differentiation. In a second part, we have studied the effect of temperature, magnetic field, polymerisation degree and polymer concentration on the enantiomeric differentiation. We have demonstrated that these various experimental parameters affect differently the enantiomeric differentiation and are important in optimising experimental conditions. Next, we have described an empirical method to determine the absolute configuration using deuterium NMR in natural abundance. Using reference analogous compounds, we have shown that quadrupolar splittings and tridimensionnal geometry of the compounds can be correlated. Then we are able to determine the unknown absolute configuration of a chiral epoxide by studying a series of analogous compounds of known absolute configuration. Finally, the same series of compounds were studied by proton and carbon-13 NMR. By calculating the Saupe order parameters of the rigid part, we have shown that we are able too to determine the absolute configuration giving the same conclusion as previously. We have extended this calculus of order parameters to the entire molecule, and we have shown that the determination of the relative stereochemistry of methylen diastereotopic protons can be done
Flambard, Alexandrine. "RMN de l'oxygène-17 et nouvelles méthodologies de RMN des solides appliquées à la caractérisation des matériaux phosphates". Lille 1, 2005. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/2005/50376-2005-Flambard.pdf.
Texto completo da fonteGilbert, Alexis. "Méthodologies pour l'étude du fractionnement isotopique photosynthétique et post-photosynthétique par RMN 13C isotopique". Nantes, 2010. http://www.theses.fr/2010NANT2049.
Texto completo da fonteA methodology has been developed that makes possible the determination of the site specific carbon-13 isotopic composition of glucose, fructose and sucrose using isotopic 13C NMR. The derivatization of sugars as their acetonides is a prerequisite to accessing the desired information. Once the protocol for the derivatization was perfected, the methodology can attain a precision of 1‰ or better. Analyses of ethanols derived from sugars by fermentation show a good correlation with results obtained by the methodology developped. The ethanol molecule has also been used as a probe to show the influence of climatic parameters (temperature, sunshine, rainfall) on the intra-molecular 13C isotope distribution in sugars from grapes. Moreover, results for sugars or starch from plants having C3 or C4 metabolism show there to be an intramolecular 13C distribution characteristic of the type of carbon assimilatory pathway exploited. The hypothesis proposed here indicates that the CO2 assimilation mode is not the only factor affecting the intra-molecular 13C distribution in sugars. It appears that isomerisation steps (involving trioses phosphates or hexoses phosphates) are crucial in terms of isotopic fractionation in the sugars produced during photosynthesis. We have therefore measured the isotope effects associated with the transformation of glucose to fructose, catalysed by glucose isomerase. A clear equilibrium isotope effect is observed, which is shown to be responsible for the C-1 enrichment and the C-2 depletion of glucose, and a significant kinetic isotope effect on the C-2 of glucose is also seen during the conversion of fructose to glucose
Angelie, Emmanuelle. "Étude méthodologique de l'imagerie spectroscopique RMN proton : analyse métabolique du vieillissement cérébral normal". Lyon 1, 1999. http://www.theses.fr/1999LYO1T116.
Texto completo da fonteZaim, Wadghiri Youssef. "Méthodologies pour l'utilisation clinique de la spectroscopie RMN : cas du phosphore-31 ; quantification ; mesures thermométriques". Lyon 1, 1994. http://www.theses.fr/1994LYO10349.
Texto completo da fonteServe, Olivier. "Méthodologies de criblages d'interactions protéines-ligands par RMN : inhibitions de la Glms et de Bcl-xL". Paris 11, 2008. http://www.theses.fr/2008PA112134.
Texto completo da fonteThe versatility of Nuclear Magnetic Resonance (NMR) allows several applications in various domains. This versatility makes it a tool of prime importance in the field of therapeutic treatments research. It allows the determination of the structure and the dynamic of the interacting molecules. We used NMR on two proteins involved in diverse pathologies : Bcl-xL, partially responsible for the apoptosis deficiency for certain cancers, and the Glms, known to give complications to people affected with type II diabetes and target in the anti-microbial fight. The goal was to enhance our understanding of the interactions between those proteins and new molecules able to inhibit their activities. Those molecules are either extract from plants (Bcl-xL study), or synthesized (Glms study). Our results allowed to give orientations about the enhancements of the therapeutic effects of the studied molecules
François, Denis. "Approche méthodologique de la mise en place d'un réseau multiservice (RMS)". Marne-la-vallée, ENPC, 1994. http://www.theses.fr/1994ENPC9436.
Texto completo da fonteUrban technical functions integration permits the development of public services in a qualitative and quantitative way, as well as a better global efficiency of the local technical organisation. It is built on an information exchange between urban technical services implemented by a divided telecommunication network. Noting on one hand the French policy-makers potential interest in functions integration, and on the other hand the lack of successful projects involving divided networks, the objective of this thesis is to provide a global answer to the problem of implementing a divided network for the integration of urban technical functions. The knowledge of the general context in which any project of this kind is created helps to explain the obstacles that were mounted preventing the success of the initiatives recorded in six French cities (Besançon, Gardanne, Nîmes, Montpellier, Nancy and Paris). On one hand, these obstacles are due to the lack of reference, real or conceptual, related to the divided network and to integration. On the other hand, they are due to the difficulties of leading an innovating multi-actor project. In order to serve as a conceptual reference for future projects, a generic network model for functions integration is proposed : the « multiservice network » (MNS). To be realistic, this model is based on an integration definition that responds to the aspirations of the urban management payers (« platform » and autonomy). In order to be used as a guideline for the project, and to take in account specifications of each city, a conception method is proposed to lead to the definition of characteristics of the local MSN (« MSN’s Director Plan »)
Fruchart, Jean-Sébastien. "Nouvelles méthodologies de synthèse en phase solide et apport de la RMN à l'angle magique pour la caractérisation d'intermédiaires sensibles". Lille 2, 2001. http://www.theses.fr/2001LIL2P012.
Texto completo da fonteChaumeil, Myriam. "Mesure du métabolisme énergétique cérébral par RMN du 31P in vivo : Validation méthodologique multimodale et application à l'étude de la neurodégénérescence". Phd thesis, Université Paris Sud - Paris XI, 2008. http://tel.archives-ouvertes.fr/tel-00743243.
Texto completo da fonteChaumeil, Myriam. "Mesure du métabolisme énérgétique cérébral par RMN du 31P in vivo : validation méthodologique multimodale et application à l'étude de la neurodégénérescence". Paris 11, 2008. http://www.theses.fr/2008PA112365.
Texto completo da fonteNeuroimaging methods have considerably developed over the last decades and offer various non-invasive approaches for measuring cerebral metabolic fluxes. Among these methods, 31P magnetic resonance spectroscopy (MRS) has the particularity to directly measure cerebral ATP synthesis, but is still methodologically challenging. In this context, a multimodal neuroimaging study was performed in order to validate the saturation transfer 31P MRS method as a quantitative measurement of brain ATP synthesis. Glucose consumption (CMRglc), TCA cycle flux (Vtca ) and rate of ATP synthesis (Vatp) were measured in primate monkeys using 18F-FDG PET scan, indirect 13C MRS and saturation transfer 31P MRS, respectively. The consistency of these three fluxes with literature and, more interestingly, one with each other, demonstrated the robustness of saturation transfer 31 P MRS for directly evaluating ATP synthesis in the living brain. The potential of 31P MRS was then evaluated on Huntington's disease patients. Stability of metabolic homeostasis, non-significant decrease in Vatp, and significant increase in cerebral pH were shown in HD patient's brain. The increase in cerebral pH, detected for the first time in MH, was correlated with motor scores. Given these results, in order to assess the precocity of pH variations associated with MH, a study was performed on a rodent chronic model of MH. A significant increase in cerebral pH was detected before any lesions evidence, showing the potentiality of pH measurement as early biomarker of MH
Botosoa, Eliot-Patrick. "Protocoles analytiques pour l'étude de la vanilline par RMN 13C isotopique en abondance naturelle : reproductibilté méthodologique, purification, origines du fractionnement isotopique". Nantes, 2008. http://www.theses.fr/2008NANT2020.
Texto completo da fonteIsotopic 13C NMR can measure the site by site isotopic deviation in 13C, making it possible to study the mechanism of the biotransformation of ferulic acid to vanillin. A priori, it was necessary to developed conditions for the reliable measurement of very small deviations with sufficient precision. Hence, it was show that, during the purification of vanillin and ferulic acid by silica gel column chromatography, unexpected site-specific isotopic deviation was introduced in different fractions recovered from the eluting peak. Both normal and inverse effects occurred, indicating that each isotopomers has a characteristic elution profile due to specific interactions with the stationary/mobile phases used. Thus, insights into the causes of non-covalent isotopic fractionation in chromatography have been obtained. The technique was applied to the biotransformation of ferulic acid to vanillin by micro-organisms, Streptomyces setonii and Amycolatopsis sp. These experiments provided clear evidence supporting the prior hypothesis of a role of a ‘hydroquinone’ intermediate in the C6C3 to C6C1 chain-shortening mechanism. This conclusion was supported by theoretical calculations of the predicted isotope effects. Future developments will include studies of the role of non-covalent interactions in isotopic fractionation, notably within the context of interactions between pollutants and contaminated soils, and the development of a general method for the authentication of the origin of natural vanillin through the analysis of the site-by-site deviations in 13C determined by 13C NMR
Rezig, Lamya. "Métabolomique permettant la découverte de biomarqueurs pertinents". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4305.
Texto completo da fonteThis thesis presents a multicompartmental metabolomics approach applied to the diagnosis of indeterminate thyroid tumours and to the characterization of the effect of fructo-oligosaccharide (FOS), a prebiotic, under high fat diet condition in a mouse model. The aim of this project is to show that such approach could lead to a more global visualization of the induced metabolic modulations, and therefore, improve the identified discriminant markers relevance. Regarding the diet study, the mono-compartmental analysis of the different mouse organs/intestine segments enabled us to identify metabolic pathways affected by the high fat diet whereas the effect of FOS could only be characterized for the feces samples collected at day 28. Regarding the thyroid cancer study, the multi-compartmental approach could not have been continued due to sample handling issues. However, the classical metabolomics analysis of the fine-needle aspiration biopsies (FNAB) from patients with benign or malignant tumours led to a clear discrimination between both groups with a predictivity similar to that of commercial diagnosis tests. In the meantime, we explored the slow-spinning NMR HR-MAS technique in order to preserve the integrity of the tissues during the experiments. The use of this technique is accompanied by a number of drawbacks that we have avoided using special NMR sequences, and putting in place a robust protocol for sample preparation. Finally, we evaluated the T1ρ filter and its applications to metabolomics as an alternative to T2 filter
Rezig, Lamya. "Métabolomique permettant la découverte de biomarqueurs pertinents". Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4305.
Texto completo da fonteThis thesis presents a multicompartmental metabolomics approach applied to the diagnosis of indeterminate thyroid tumours and to the characterization of the effect of fructo-oligosaccharide (FOS), a prebiotic, under high fat diet condition in a mouse model. The aim of this project is to show that such approach could lead to a more global visualization of the induced metabolic modulations, and therefore, improve the identified discriminant markers relevance. Regarding the diet study, the mono-compartmental analysis of the different mouse organs/intestine segments enabled us to identify metabolic pathways affected by the high fat diet whereas the effect of FOS could only be characterized for the feces samples collected at day 28. Regarding the thyroid cancer study, the multi-compartmental approach could not have been continued due to sample handling issues. However, the classical metabolomics analysis of the fine-needle aspiration biopsies (FNAB) from patients with benign or malignant tumours led to a clear discrimination between both groups with a predictivity similar to that of commercial diagnosis tests. In the meantime, we explored the slow-spinning NMR HR-MAS technique in order to preserve the integrity of the tissues during the experiments. The use of this technique is accompanied by a number of drawbacks that we have avoided using special NMR sequences, and putting in place a robust protocol for sample preparation. Finally, we evaluated the T1ρ filter and its applications to metabolomics as an alternative to T2 filter
Roudier, Emilie. "Approches fondamentales et méthodologique de l'étude de l'hypoxie cellulaire par RMN du carbone 13, étude de l'hypoxie sur le métabolisme de la lignée HepG2 : influence du pyruvate, développement d'un système intégré pour l'étude par RMN de cellules vivantes". Université Joseph Fourier (Grenoble), 2002. http://www.theses.fr/2002GRE19014.
Texto completo da fonteThis work consists in two parts dedicated to the in vitro study of hypoxia by 13C-NMR spectroscopy. HepG2 line was used as cellular model. A fundamental study concerns metabolic pyruvate effects induced by hypoxia. The NMR analysis of PCA extracts of cells incubated with [1-13C]glucose shows that pyruvate inhibits hypoxia induced glycérol-3-phosphate accumulation. Cell integrity observation points out that it reduces hypoxia induced DNA fragmentation. Metabolic and antioxidizing properties of pyruvate could explain those effects. A methodological part describes a integrated cell culture system allowing dynamic NMR study of living cells metabolism under hypoxia. Protocols and conditions of cellular culture were established for two bioreactor types (hollow fibers and "spaghetti") and an oxygen regulation has been adapted to the cell culture system. Preliminary NMR analysis are presented
Pitoux, Daisy. "Développement de nouvelles expériences de corrélation en RMN haute-résolution mettant en œuvre un encodage spatial fréquentiel de l'échantillon". Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112106/document.
Texto completo da fonteMost of the developments that have been made during the last years in the field of fast NMR have allowed for considerably accelerating the acquisition of multidimensional experiments. However, the analysis of proton-proton spin interactions, which are very important structural probes in molecules, still constitutes a tedious and time-consuming analytical process for most of the chemists. One reason is the complexity and the high number of homonuclear couplings that contribute to the overall lineshape in proton spectra, even for small or medium-sized compounds. It is thus nowadays very difficult to optimize both the resolution of correlation spectra, and the experimental time needed to acquire them, using state of the art high resolution methods. This thesis project aimed at developing a novel and general approach based on a spatial frequency encoding of the NMR sample in order to simplify and thus to accelerate the analysis of complex molecular systems. Spatial frequency encoding consists in controlling selectively spin evolutions in localized regions of the sample, and in combining them into high resolution experiments whose analytical content is easily accessible. In a first part, the theory of spatial frequency encoding is presented. A general method for simulating the encoded NMR signal is introduced, and it is applied to describe the localized selective excitation process of a model spin system, from the analysis of a single spin coherence, to the reconstruction of the whole NMR spectrum encoded throughout the sample. The magnetic field dependence of the slice selection process, as well as the overall sensitivity is also addressed through this simulation tool. In a second part, two methodological developments are presented. Firstly, the PCR-COSY experiment gives access, in a single spectrum, to a fully edited and assignable measurement of all the proton-proton scalar couplings in a given molecule. Secondly, the push-G-SERF experiment allows for measuring all the couplings involving a selected proton on correlations showing a J-resolved and a -resolved structure in the indirect and direct domain of the resulting 2D spectrum, respectively. In a third part, high-resolution experiments based on a spatial frequency encoding of the sample are applied to the conformational analysis of a synthetic saccharide. First, advantages and drawbacks of an implementation of spatial frequency encoded techniques at very high field are discussed. Then, a conformational analysis strategy based on J-edited spectroscopy is introduced, and successfully applied to the study of this oligosaccharide
Bertoldi, Didier. "Apport méthodologique aux mesures de la perfusion et du métabolisme énergétique par RMN in vivo chez le petit animal et applications à l'exploration fonctionnelle du muscle strié squelettique squelettique". Paris 6, 2006. http://www.theses.fr/2006PA066521.
Texto completo da fonteBertaut, Éléonore. "Développement de nouvelles méthodologies pour la calorimétrie de titration isotherme : Applications aux domaines de l'environnement et de la santé". Thesis, Littoral, 2016. http://www.theses.fr/2016DUNK0424/document.
Texto completo da fonteThis work was dedicated to the development of new isothermal titration calorimetry (ITC) methodologies for the characterization of intramolecula affinities, after validation of model system via capillary electrophoresis, UV-visible and NMR spectroscopy. We have demonstrated that the coupling of unconventional experiments with the conventional protocols generally improves the calorimetric characterization, with a dramatic decrease of the uncertainties on thermodynamic parameters. The potential of global analysis applied to differentiated experiments was evaluated on a theoretical level, allowing the definition of optimal experiments, depending on the type of studied complex. These strategies also enabled, on a experimental point of view, the study of complexations which cannot be analyzed by conventional approaches, in the case of complexes involving cyclodextrins or albumin. Indeed, our strategies overcomes the difficulties associated with athermic complexes, with complexes of low affinity, with multiple equilibria and with the low solubility of interacting partners. Finally, the evaluation of a new thermo-kinetic treatment of ITC thermograms has been achieved, further increasing the potential of this technique in the characterization of molecular interactions
Lavergne, Fabien. "Méthodologie de synthèse de lois de commandes non-linéaires et robustes : application au suivi de trajectoire des avions de transport". Toulouse 3, 2005. http://www.theses.fr/2005TOU30248.
Texto completo da fonteThe work presented in this PhD thesis report is situated within the framework of the nonlinear and robust control of transport aircrafts. The purpose of this thesis is to couple the properties of nonlinear controllers (adaptation to the aircraft nonlinearities, explicit controllers synthesis, easy and decoupled setting once the synthesis is achieved, genericity of the obtained control laws) with essential robustness properties. Indeed, to guarantee the flight safety, both in manual handling and in automatic control, the control laws have to present strong robust stability and performances properties. After an introduction to the industrial and research context, a "techniques, methods and tools" part allows us to point out the thesis contributions in the nonlinear robust control and automatic modelling domains. The nonlinear robust control technique presented, called RMI control (for "Robust Multi-Inversion") is based on the now classical Nonlinear Dynamic Inversion (NDI) technique, notably studied at Airbus for some years (Fabrice VILLAUME, Jean DUPREZ), and is robustified by adding a complementary observation loop. We also present an automatic tool creating nonlinear, multivariable and embeddable models, as well as neural networks correlated methods. This tool is mandatory for the industrialization of our model-based flight control laws. Then the applicative part of the thesis underlines the specificities of the "aircraft" system and proposes flight control laws architectures, associated reference trajectories, and the advanced validation of the whole system by simulations performed on Airbus' certified simulator. Finally, after a conclusion on the main results and perspectives linked to the thesis, we propose annexes allowing to go further into the details of certain parts of our study
Lavergne, Fabien. "Méthodologie de synthèse de lois de commandes non-linéaires etrobustes : Application au suivi de trajectoire des avions de transport". Phd thesis, Université Paul Sabatier - Toulouse III, 2005. http://tel.archives-ouvertes.fr/tel-00011557.
Texto completo da fontePakleza, Christophe. "Méthodologies du repliement de l'ADN à différentes échelles : modélisation moléculaire des épingles à cheveux à partir de la théorie de l'élasticité et de contraintes RMN : analyse et mesure de la courbure et de la flexibilité à partir de microscopies". Paris 6, 2002. http://www.theses.fr/2002PA066283.
Texto completo da fonteAlbrecht, Remy. "Co-compostage de boues de station d'épuration et de déchets verts : Nouvelle méthodologie du suivi des transformations de la matière organique". Phd thesis, 2007. http://tel.archives-ouvertes.fr/tel-00174775.
Texto completo da fonte