Artigos de revistas: "Mediated traces"

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Parolin, Laura Lucia. "Working and knowing in technology-mediated environments". Communication & Language at Work 7, n.º 1 (7 de dezembro de 2020): 123–35. http://dx.doi.org/10.7146/claw.v7i1.123265.

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Comprehensions of how technology-mediated environments work are marked by a lack of theoretical sophistication about how expertise emerges and develops. Using a practice-based approach to workplace learning and knowing, a case of telecardiological consultation is discussed, where a dedicated call center works by connecting general practitioners (GPs) with remote cardiologists. The service allows GPsto send electrocardiogram traces (ECGs) and discuss the needs of patients with a cardiologist. The role of materials (ECG traces, the recording machine, infrastructure), and communication (synchronous communication in the form of a phone call) are considered in the practical application of the service. It is argued that being an expert telecardiologist entails the ability to align heterogeneous elements, and co-construct, a reliable interpretation of the patient’s situation alongside a doctor. To do that when the situation is not immediately clear, necessitates both doctors discursively mobilize different bio-physiological, chemical, material, social and psychological aspects of a patient’s condition, in order to arrive at a reliable interpretation. Thanks to a practice-based sensitivity, I analyze the case study reading these interactions as competent material-discursive practices.

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Opriș-Belinski, Daniela, Claudia Oana Cobilinschi, Simona Caraiola, Raluca Ungureanu, Ana-Maria Cotae, Ioana Marina Grințescu, Cristian Cobilinschi et al. "Trace Element Deficiency in Systemic Sclerosis—Too Much Effort for Some Traces?" Nutrients 16, n.º 13 (27 de junho de 2024): 2053. http://dx.doi.org/10.3390/nu16132053.

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Trace elements are essential for several physiological processes. To date, various data have suggested that inadequate levels of trace elements may be involved in the pathogenesis of different chronic diseases, including immune-mediated ones, or may develop during their course. Systemic sclerosis (SSc) is a complex autoimmune multisystemic disease, primarily characterized by microvascular dysregulation, the widespread activation of the immune system and tissue fibrosis. According to the latest reports regarding the pathogenesis of SSc, the main pathophysiological processes—inflammation, vasculopathy and fibrosis—may include various trace element derangements. The present literature review aims to update the available data regarding iron, zinc, copper and selenium status in SSc as well as to underline the possible implications of these trace elements in the complexity of the pathogenic process of the disease. We observe that the status of trace elements in SSc plays a crucial role in numerous pathogenic processes, emphasizing the necessity for proper monitoring and supplementation. The reported data are heterogenous and scarce, and future studies are needed in order to draw clearer conclusions about their complete spectrum.

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Koch, Katrin, Dave Algar e Klaus Schwenk. "Feral Cat Globetrotters: genetic traces of historical human‐mediated dispersal". Ecology and Evolution 6, n.º 15 (30 de junho de 2016): 5321–32. http://dx.doi.org/10.1002/ece3.2261.

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Thakur, Himali. "Mediated Anarchy in Ursula Le Guin’s The Dispossessed". Configurations 32, n.º 3 (junho de 2024): 259–78. http://dx.doi.org/10.1353/con.2024.a932025.

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ABSTRACT: This essay argues that the anarchy of Odonian society depends upon the “mediation” afforded by techne . The social organism is a tool that enables Odonians to cultivate reflective relationships on mediation, and hence with each other. Odonian society is a “mediated anarchy.” Shevek’s corrective to the Odonian social organism is to re-center individual existential experience in the use of tools. The essay traces the novel’s roots in debates of determinism and freedom in evolutionary biology and media technologies, borrowing Peter Kropotkin’s anarchist communism. The essay ends with a discussion of the insights Shevek’s philosophy provides into media theory.

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Akoumianakis, Demosthenes, Giannis Milolidakis, George Vlachakis, Nikolas Karadimitriou e Giorgos Ktistakis. "Retaining and Exploring Digital Traces". International Journal of Virtual Communities and Social Networking 3, n.º 4 (outubro de 2011): 46–65. http://dx.doi.org/10.4018/jvcsn.2011100104.

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The present work rests and elaborates on the assumption that social technologies are increasingly turned into computer-mediated virtual settlements, thereby allowing the excavation of a variety of enacted cyber-phenomena such as ad hoc online ensembles, informal social networks and virtual communities, on the grounds of ‘digital’ traces or remains. In this vein, the authors motivate and present a method for virtual excavations that is tightly coupled to a transformational technology such as knowledge visualization. The analytical and explanatory value of the method is assessed using two case studies addressing representative genres of social technologies, namely web sites augmented with social plug-ins and social networking services. Analysis reveals intrinsic aspects of ‘digital’ traces and remains, the form they take in today’s social web and the means through which they can be excavated and transformed to useful information. It turns out that such virtual excavations, when organized and conducted carefully, can be of benefit to enterprises, service organizations and public sector institutions. In addition, their tight coupling with knowledge visualization eliminates extensive data analysis as much of this work can be done using the visualization. On the other hand, and depending on the size of digital trace data, the choice of visualizations and the underlying toolkit are of paramount importance.

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Higuchi, Kazuhiro, Takuhiro Tago, Yusuke Kokubo, Motoki Ito, Masanori Tayu, Shigeo Sugiyama e Tomomi Kawasaki. "A metal-free biaryl coupling reaction activated by a sulfonium salt". Organic Chemistry Frontiers 5, n.º 22 (2018): 3219–25. http://dx.doi.org/10.1039/c8qo00798e.

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A metal-free biaryl coupling reaction of phenol or aryl ethers mediated by a sulfonium salt formed from diphenyl sulfoxide and trifluoromethanesulfonic anhydride has been developed. The method is a rapid, one-pot reaction, leaving no traces of the sulfonium moiety in the product.

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Banwell, MG, JH Ryan e DA Winkler. "Carbocation-Mediated Rearrangements Within [n.m.1]Propellane Frameworks". Australian Journal of Chemistry 44, n.º 4 (1991): 593. http://dx.doi.org/10.1071/ch9910593.

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Mild thermolysis of the tetracyclic mesylate (6) in the presence of traces of mineral acid afforded a mixture of the rearrangement products (21) and (22) as well the σ-anti- bishomotetralin (20). On treatment with methanesulfonic acid in dichloromethane, compound (20) gives rise to the [5.4.1] propellene (21) which, on prolonged exposure to these reaction conditions, isomerizes to the mesyloxymethyl compound (22). Under the same conditions, the σ-anti- bishomoindan (4) is converted into the [5.3.1] propellene (3) which, in turn, slowly rearranges to the [4.3.1] propellene (23). A mechanistic rationalization of these observations is advanced which also accounts for the formation of the novel by-product (16) observed during Simmons-Smith cyclopropanation of allylic alcohol (15a).

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ZONNEVELD, J.-P., Z. E. E. ZONNEVELD, W. S. BARTELS, M. K. GINGRAS e J. J. HEAD. "BONE MODIFICATION FEATURES RESULTING FROM BARNACLE ATTACHMENT ON THE BONES OF LOGGERHEAD SEA TURTLES (Caretta caretta), CUMBERLAND ISLAND, GEORGIA, USA: IMPLICATIONS FOR THE PALEOECOLOGICAL, AND TAPHONOMIC ANALYSES OF FOSSIL SEA TURTLES". PALAIOS 37, n.º 11 (21 de novembro de 2022): 650–70. http://dx.doi.org/10.2110/palo.2022.021.

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Abstract Sea turtles are characterized by a wide variety of invertebrate ectoparasites. Few of these ectoparasites leave a permanent indication of their presence on the skeletal remains of their host taxa and thus represent ecological information doomed to be lost in the paleontological record. Some barnacle taxa provide an exception to this, in that they cause the formation of small, subcircular to circular divots, pits, and holes on the skull, mandible, carapace or plastron of sea turtles. Loggerhead Sea Turtle (Caretta caretta) skeletons from Cumberland Island, Georgia, USA were examined to assess the presence, frequency, and loci of occurrence of barnacle pits, and to establish which taxa are involved in pit development. Six types of divot and pit attributed to barnacles are identified in this study. Type I traces are shallow, oval/semi-circular in outline, with smooth, gently sloped bases. Type II traces are deep, hemispherical pits with smooth bases. Type III traces are deep, circular to subcircular pits with flat bases. Type IV traces are deep, circular to subcircular pits with multiple (4–6) small sub-pits on their bases. Type V traces are cylindrical, penetrative holes. Type VI traces comprise shallow ring-shaped grooves on the surface of the bone. Type I through III traces are identical to the ichnotaxon Karethraichnus lakkos. Type IV traces have not, as yet, been described in the rock record. Type V traces are identical to K. fiale. Type VI traces are identical to Thatchtelithichnus holmani. Barnacle taxa identified as emplacing non-penetrative divots and pits on C. caretta skulls, mandibles, and shell bones include Chelonibia caretta (Type I), Platylepas hexastylos (Types I–IV), Calyptolepas bjorndalae (Types I and II), and Stomatolepas elegans (Types I and II). Type V traces were most likely emplaced by either Stephanolepas muricata or Chelolepas cheloniae. Type VI traces reflect the former attachment of balanid or lepadid barnacles. Embedded barnacles were observed in epidermal material associated with Types I through IV traces but not for Type V and VI traces and thus the relationship is inferred for these latter traces. Barnacle-related pits, divots, and holes are believed to result from barnacle mediated chemical corrosion into the outer surface of sea turtle bone. The occurrence of these traces provides one of the few preservable lines of evidence of barnacle interactions with sea turtle hosts. Identification of definitive barnacle borings in fossil material will provide evidence of the evolution of platylepadid barnacles and the development of their commensal relationship with chelonid turtles.

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Moravčíková, Nina, Radovan Kasarda, Radoslav Židek, John Colin McEwan, Rudiger Brauning, Tomás Landete-Castillejos, Louis Chonco, Juraj Ciberej e Jaroslav Pokorádi. "Traces of Human-Mediated Selection in the Gene Pool of Red Deer Populations". Animals 13, n.º 15 (4 de agosto de 2023): 2525. http://dx.doi.org/10.3390/ani13152525.

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In this study, we analysed the effect of human-mediated selection on the gene pool of wild and farmed red deer populations based on genotyping-by-sequencing data. The farmed red deer sample covered populations spread across seven countries and two continents (France, Germany, Hungary, Latvia, New Zealand, Poland, and Slovakia). The Slovak and Spain wild red deer populations (the latter one in a large game estate) were used as control outgroups. The gene flow intensity, relationship and admixture among populations were tested by the Bayesian approach and discriminant analysis of principal components (DAPC). The highest gene diversity (He = 0.19) and the lowest genomic inbreeding (FHOM = 0.04) found in Slovak wild population confirmed our hypothesis that artificial selection accompanied by bottlenecks has led to the increase in overall genomic homozygosity. The Bayesian approach and DAPC consistently identified three separate genetic groups. As expected, the farmed populations were clustered together, while the Slovak and Spanish populations formed two separate clusters. Identified traces of genetic admixture in the gene pool of farmed populations reflected a strong contemporary migration rate between them. This study suggests that even if the history of deer farming has been shorter than traditional livestock species, it may leave significant traces in the genome structure.

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Ochoa, Xavier, e Marcelo Worsley. "Editorial: Augmenting Learning Analytics with Multimodal Sensory Data". Journal of Learning Analytics 3, n.º 2 (17 de setembro de 2016): 213–19. http://dx.doi.org/10.18608/jla.2016.32.10.

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The goal of Learning Analytics is to understand and improve learning. However, learning does not always occur through or mediated by a technological system that can collect digital traces. To be able to study learning in non-technology centered environments, several signals, such as video and audio, should be captured, processed and analyzed to produce traces of the actions and interactions of the actors of the learning process. The use and integration of the different modalities present in those signals is known as Multimodal Learning Analytics. This editorial presents a brief introduction to this new variation of Learning Analytics and summarizes the four representative articles included in this special issue. The editorial closes with a small discussion about the current opportunities and challenges in multimodal learning analytics.

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Ollagnier-Beldame, Magali. "Foot-Printing E-Learners’ Activity". International Journal of Knowledge Management 6, n.º 3 (julho de 2010): 65–77. http://dx.doi.org/10.4018/jkm.2010070104.

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Information and communication technologies have invaded the field of training, though their performances have been judged by companies to be insufficient. Among the origins of this state of affairs, the author considers that the lack of knowledge of what happens in a “real use situation” plays an important role. Indeed, understanding what is involved in learners-system interactions is fundamental to improve the system appropriation and its efficient usage. This appropriation is a dual necessity for learners as they must take over the offered possibilities of interactions and acquire the necessary knowledge. As appropriation is made through offered interactions, the author considers computer interactions traces as potential appropriation facilitators. This conceptual article presents bibliographical research concerning the use of computer interactions traces and proposes a classification of ‘tracing systems’. Additionally, the links between these works and the process of appropriation in an instrumented training situation is provided, while the author also presents an experimental study conducted on the role of traces of interactions in a collaborative mediated task by using a numerical environment.

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Florea, Cristina, e Horia Petride. "RuO4-mediated oxidation of secondary amines: Part 1. Are hydroxylamines main intermediates?" Journal of the Serbian Chemical Society 81, n.º 5 (2016): 475–86. http://dx.doi.org/10.2298/jsc151215029f.

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The RuO4-catalyzed oxidation of secondary amines Bn-NH-CH2R (1a-b; R=H, Me) gave mainly amides, but minute amounts of nitrones PhCH=N(O)-CH2R (9a-b) and traces of Bn-N(OH)-CH2R (R=H, 4a) were also detected. In the presence of cyanide, up to 22 reaction products were identified, but mainly ?-aminonitriles. Comparison of the oxidation products of 1a-b with those of 4a-b, 9a-b, and Bn-N(O)=CHR (10a-b) showed that 4a-b cannot be main reaction intermediates formed from 1a-b.

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Hoshino, Osamu. "Regulation of Local Ambient GABA Levels via Transporter-Mediated GABA Import and Export for Subliminal Learning". Neural Computation 27, n.º 6 (junho de 2015): 1223–51. http://dx.doi.org/10.1162/neco_a_00733.

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Perception of supraliminal stimuli might in general be reflected in bursts of action potentials (spikes), and their memory traces could be formed through spike-timing-dependent plasticity (STDP). Memory traces for subliminal stimuli might be formed in a different manner, because subliminal stimulation evokes a fraction (but not a burst) of spikes. Simulations of a cortical neural network model showed that a subliminal stimulus that was too brief (10 msec) to perceive transiently (more than about 500 msec) depolarized stimulus-relevant principal cells and hyperpolarized stimulus-irrelevant principal cells in a subthreshold manner. This led to a small increase or decrease in ongoing-spontaneous spiking activity frequency (less than 1 Hz). Synaptic modification based on STDP during this period effectively enhanced relevant synaptic weights, by which subliminal learning was improved. GABA transporters on GABAergic interneurons modulated local levels of ambient GABA. Ambient GABA molecules acted on extrasynaptic receptors, provided principal cells with tonic inhibitory currents, and contributed to achieving the subthreshold neuronal state. We suggest that ongoing-spontaneous synaptic alteration through STDP following subliminal stimulation may be a possible neuronal mechanism for leaving its memory trace in cortical circuitry. Regulation of local ambient GABA levels by transporter-mediated GABA import and export may be crucial for subliminal learning.

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Li, Yu, Yong Feng, Bin Yang, Zequn Yang e Kaimin Shih. "Activation of peroxymonosulfate by molybdenum disulfide-mediated traces of Fe(III) for sulfadiazine degradation". Chemosphere 283 (novembro de 2021): 131212. http://dx.doi.org/10.1016/j.chemosphere.2021.131212.

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Wu, Yikang, Zheng-Yu Yue e Yu-Lin Wu. "Interaction of Qinghaosu (Artemisinin) with Cysteine Sulfhydryl Mediated by Traces of Non-Heme Iron". Angewandte Chemie International Edition 38, n.º 17 (3 de setembro de 1999): 2580–82. http://dx.doi.org/10.1002/(sici)1521-3773(19990903)38:17<2580::aid-anie2580>3.0.co;2-j.

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Reyes, Cornelia. "Eliciting data on social relationships: The use of hand-drawn network maps in tracing the perception of digitally mediated social ties". International Review of Social Research 6, n.º 4 (1 de outubro de 2016): 256–68. http://dx.doi.org/10.1515/irsr-2016-0027.

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Abstract The emergence of online social networking platforms established a new way of identifying ourselves as being related to other individuals. Previous research has looked at the impact these ‘networking’ applications have on individuals’ everyday lives. Nonetheless, obtaining convincing data on how individuals assess the quality of digitally mediated social relationships has often been perceived challenging. Drawing on a methodological framework rooted in a social network analysis approach, this paper traces the suitability of hand-drawn network maps for eliciting data on how individuals give meaning to digitally mediated social relationships by comparing it to traditional tools used in social network analysis. The results show that using hand-drawn network maps in this particular context provides respondents with a more tangible resource to recall data on digitally mediated social relationships. In particular, this methodological approach elicits substantial data on abstract thematic areas that are typically difficult to recall using standardised techniques.

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Ganguly, Debjani. "The World Novel, Mediated Wars and Exorbitant Witnessing". Cambridge Journal of Postcolonial Literary Inquiry 1, n.º 1 (12 de fevereiro de 2014): 11–31. http://dx.doi.org/10.1017/pli.2013.11.

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This essay traces the emergence of a new contemporary novel form at the conjunction of global violence in the wake of the Cold War, digital hyperconnectivity, and a mediated infrastructure of sympathy. Since the first Gulf War, and more so, in the rhetoric presaging the wars in Iraq and Afghanistan, we have come to accept that there is very little difference between the technologies used to wage war and those used to view it. This essay argues that the novels of our time are not contiguous with contemporary cinematic or televisual or new media genres in representing the immediacy of violence, but are rather texts that graph the sedimented and recursive history of such mediation. Their alternative way of documenting “witness”—that is, of abstracting the architectonics of testimonial work—urges us to focus not so much on the question ofvisibility—and its stock thematics of overexposure and desensitization—as on thelegibilityof this new mode of witnessing. The distinction between visibility and legibility amounts to calibrating differently theworkof witnessing in novels, their textual and tropological play with multiple modes of spectatorship and engagement, and their distinctively different braiding of the factual and the evidentiary in comparison with genres of the visual.

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Ding, A. H., e C. F. Nathan. "Trace levels of bacterial lipopolysaccharide prevent interferon-gamma or tumor necrosis factor-alpha from enhancing mouse peritoneal macrophage respiratory burst capacity." Journal of Immunology 139, n.º 6 (15 de setembro de 1987): 1971–77. http://dx.doi.org/10.4049/jimmunol.139.6.1971.

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Abstract Preexposure of resident mouse peritoneal macrophages for 1 hr to traces of bacterial lipopolysaccharide (LPS) (less than or equal to 1 ng/ml) rendered the cells refractory to activation by recombinant interferon-gamma (rIFN gamma) or recombinant tumor necrosis factor-alpha (rTNF alpha), as evaluated by release of H2O2 upon stimulation with phorbol myristate acetate. Inhibition persisted for at least 4 days. Fifty percent inhibition of activation mediated by rIFN gamma followed 1 hr exposure to 10 pg/ml LPS. Fifty percent inhibition of activation mediated by rTNF alpha was achieved with 1 hr exposure to 1 pg/ml LPS. Such low levels LPS exposures (concentration X time) are far below those reported for many other actions of LPS on host cells. Inhibition was partially prevented by the cyclooxygenase inhibitors indomethacin, ibuprofen, and acetylsalicylic acid. Exogenous prostaglandins PGE1 and PGE2, and the 3',5'-cyclic adenosine monophosphate analog dibutyryl cyclic adenosine monophosphate (cAMP), mimicked the inhibitory effect of LPS in a dose-dependent manner, consistent with the hypothesis that formation of endogenous cyclooxygenase products in response to LPS may elevate intracellular cAMP and that the latter may mediate the observed inhibition. In addition, neutralizing antibody against IFN alpha and IFN beta selectively prevented LPS inhibition of activation mediated by rIFN gamma, but not by rTNF alpha. This suggests that IFN alpha and/or IFN beta induced by LPS also contributed to inhibition of activation by rIFN gamma. Thus, release of LPS may afford microorganisms a means by which to interfere with immunologically mediated enhancement of the respiratory burst-dependent antimicrobial capacity of macrophages.

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Ross, Fiona. "Linguistic Bearings and Testimonial Practices". Journal of Language and Politics 5, n.º 1 (14 de abril de 2006): 111–24. http://dx.doi.org/10.1075/jlp.5.1.07ros.

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The paper considers women’s testimonies before the South African Truth and Reconciliation Commission, tracing the complexities of speaking about suffering. A growing literature suggests that violence and horror corrupt language and interrupt its flow. Testimonial practices focused on violence’s recall then occupy unstable grounds. Arguing that testimony is mediated by the subject positions from which women speak and that these are shaped by cultural convention, the paper traces the effects of ‘modes of discomfort’, drawing attention to the faultlines between words and experience when violence is recalled.

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Graham, François, Jean‐Christoph Caubet e Philippe A. Eigenmann. "Can my child with IgE‐mediated peanut allergy introduce foods labeled with “may contain traces”?" Pediatric Allergy and Immunology 31, n.º 6 (15 de junho de 2020): 601–7. http://dx.doi.org/10.1111/pai.13244.

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Oelkers, Marieelen, Hannes Witt, Partho Halder, Reinhard Jahn e Andreas Janshoff. "SNARE-mediated membrane fusion trajectories derived from force-clamp experiments". Proceedings of the National Academy of Sciences 113, n.º 46 (2 de novembro de 2016): 13051–56. http://dx.doi.org/10.1073/pnas.1615885113.

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Fusion of lipid bilayers is usually prevented by large energy barriers arising from removal of the hydration shell, formation of highly curved structures, and, eventually, fusion pore widening. Here, we measured the force-dependent lifetime of fusion intermediates using membrane-coated silica spheres attached to cantilevers of an atomic-force microscope. Analysis of time traces obtained from force-clamp experiments allowed us to unequivocally assign steps in deflection of the cantilever to membrane states during the SNARE-mediated fusion with solid-supported lipid bilayers. Force-dependent lifetime distributions of the various intermediate fusion states allowed us to propose the likelihood of different fusion pathways and to assess the main free energy barrier, which was found to be related to passing of the hydration barrier and splaying of lipids to eventually enter either the fully fused state or a long-lived hemifusion intermediate. The results were compared with SNARE mutants that arrest adjacent bilayers in the docked state and membranes in the absence of SNAREs but presence of PEG or calcium. Only with the WT SNARE construct was appreciable merging of both bilayers observed.

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Job, Veronika, Jana Nikitin, Sophia X. Zhang, Priyanka B. Carr e Gregory M. Walton. "Social Traces of Generic Humans Increase the Value of Everyday Objects". Personality and Social Psychology Bulletin 43, n.º 6 (16 de abril de 2017): 785–92. http://dx.doi.org/10.1177/0146167217697694.

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Past research finds that people behave as though the particular qualities of specific, strongly valenced individuals “rub off” on objects. People thus value a sweater worn by George Clooney but are disgusted by one worn by Hitler. We hypothesized that social traces of generic humans can also adhere to objects, increasing their value. Experiments 1 and 2 found that simply marking that consumer products (mugs, giftwrap) were made by generic strangers (e.g., “by people using machines” vs. “by machines run by people”) increased their perceived value. Experiment 3 demonstrated that this effect was mediated by thoughts about attention the object received from other people, which, in turn, led people to see the object as possessing more positive social qualities (e.g., friendly), increasing valuation. The results suggest that generic humans are perceived positively, possessing warm social qualities, and these can “rub off” and adhere to everyday objects increasing their value.

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Moscovitch, Morris. "Recovered consciousness: A proposal for making consciousness integral to neuropsychological theories of memory in humans and nonhumans". Behavioral and Brain Sciences 19, n.º 4 (dezembro de 1996): 768–70. http://dx.doi.org/10.1017/s0140525x00043946.

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AbstractWhy is consciousness associated with recovery of memories that are initially dependent on the hippocampal system? A hypothesis is proposed that the medial temporal lobe/hippocampal complex (MTL/H) receives as its input only information that is consciously apprehended. By a process termed “cohesion,” the MTL/H binds into a memory trace those neural elements that mediated the conscious experience so that effectively, “consciousness” is an integral part of the memory trace. It is the phenomenological records of events (Conway 1992), integrated consciousness-content packets, that are recovered when memory traces are retrieved.

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Moskovits, Martin. "Canada’s early contributions to plasmonics". Canadian Journal of Chemistry 97, n.º 6 (junho de 2019): 483–87. http://dx.doi.org/10.1139/cjc-2018-0365.

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The field of plasmonics — the study of collective electron excitation in nanostructured metal and other conductors — is currently highly active with research foci in a number of related fields, including plasmon-enhanced spectroscopies and plasmon-mediated photochemical and photocatalytic processes through which the energy stored temporarily as plasmons can be used to enable and (or) accelerate photochemistry. This enhancement is accomplished either by the action of the large optical fields produced in the vicinity of plasmonic nanostructures or mediated by the energetic electrons and holes surviving transiently following the dephasing of the plasmon. This article traces the early contributions to the foundation of the current field of plasmonics by two scientists working in Canada in the early 1970s, J. P. Marton at McMaster University and Welwyn Corporation and the current author while he was at the University of Toronto.

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Bayramoğlu, Yener. "Remembering hope: mediated queer futurity and counterpublics in Turkey’s authoritarian times". New Perspectives on Turkey 64 (26 de abril de 2021): 173–95. http://dx.doi.org/10.1017/npt.2021.14.

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AbstractThis article explores how hope and visions of the future have left their mark on media discourse in Turkey. Looking back at some of the events that took place in the 1980s, a decade that was shaped by the aftermath of the 1980 coup d’état, and considering them alongside what has happened since the ban of Istanbul’s Pride march in 2015, it examines traces of hope in two periods of recent Turkish history characterized by authoritarianism. Drawing on an array of visual and textual material drawn from the tabloid press, magazines, newspapers, and digital platforms, it inquires into how queer hope manages to infiltrate mediated publics even in times of pessimism and hopelessness. Based upon analysis of an archive of discourses on resistance, solidarity, and future, it argues that queer hope not only helps to map out possible future routes for queer lives in (and beyond) Turkey, but also operates as a driving political force that sustains queers’ determination to maintain their presence in the public sphere despite repressive nationalist, militarist, Islamist, and authoritarian regimes.

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Ollagnier-Beldame, Magali, Christian Brassac e Alain Mille. "Traces and activity: a case study of a joint writing process mediated by a digital environment". Behaviour & Information Technology 33, n.º 9 (29 de outubro de 2013): 954–67. http://dx.doi.org/10.1080/0144929x.2013.819528.

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Polenz, Ingmar, Friedrich Georg Schmidt e Stefan Spange. "Acceleration of the imine base/isocyanate (IBI)-mediated polymerization of MMA caused by ionic liquid traces". Journal of Polymer Science Part A: Polymer Chemistry 51, n.º 3 (6 de novembro de 2012): 687–95. http://dx.doi.org/10.1002/pola.26422.

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Starosta, Anita. "Gardens of Things: The Vicissitudes of Disappearance". Intermédialités, n.º 10 (10 de agosto de 2011): 147–63. http://dx.doi.org/10.7202/1005558ar.

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This essay traces the disappearance of the Soviet Union through aesthetical and everyday objects, and through an organization of the ethical and economic values that mark the so-called post-Soviet world. Looking through the different ways historical changes are mediated and made apprehensible, I propose to read Ryszard Kapuscinski's non-fictional account Imperium, Zbigniew Herbert's poems “Elegy for the Departure of Pen, Ink and Lamp” and “The Envoy of Mr. Cogito,” and Krzysztof Kieslowski's film No End (1984). I argue that the vicissitudes of disappearance question notions of historical rupture, making visible the processes of cultural renegotiation and reconstitution.

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Stöcker, Walter, Konstantin Karmilin, André Hildebrand, Hagen Westphal, Irene Yiallouros, Ralf Weiskirchen, Eileen Dietzel, Julia Floehr e Willi Jahnen-Dechent. "Mammalian gamete fusion depends on the inhibition of ovastacin by fetuin-B". Biological Chemistry 395, n.º 10 (1 de outubro de 2014): 1195–99. http://dx.doi.org/10.1515/hsz-2014-0189.

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Abstract The zona pellucida, a glycoprotein matrix surrounding the mammalian oocyte, hardens after intrusion of the first spermatozoon, thus protecting the embryo until implantation and preventing multiple fertilizations (polyspermy). Definitive zona hardening is mediated by the metalloprotease ovastacin, which is released from cortical granules of the oocyte upon sperm penetration. However, traces of ovastacin seep from unfertilized eggs to cause zona hardening even in the absence of sperm. These small amounts of protease are inactivated by the plasma protein fetuin-B, thus keeping eggs fertilizable. Once a sperm has penetrated the egg, ovastacin from cortical vesicles overrides fetuin-B and initiates zona hardening.

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Vieira, Patrícia, e Łukasz Kraj. "Fitografia: literatura jako pisanie roślin". Wielogłos, n.º 1 (51) (2022): 31–48. http://dx.doi.org/10.4467/2084395xwi.22.009.16602.

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Phytographia: Literature as Plant Writing This article develops the notion of plant writing or phytographia, the roots of which go back to the early modern concept of signatura rerum, as well as, more recently, to Walter Benjamin’s idea of a “language of things”and to Jacques Derrida’s arche-writing. Phytographia designates the encounter between the plants’inscription in the world and the traces of that imprint left in literary works, mediated by the artistic perspective of the author. The final section of the essay turns to the so-called “jungle novel,”set in the Amazonian rainforest, as an instantiation of phytographia.

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Heemsbergen, Luke, Greg Bowtell e Jordan Vincent. "Conceptualising Augmented Reality: From virtual divides to mediated dynamics". Convergence: The International Journal of Research into New Media Technologies 27, n.º 3 (10 de fevereiro de 2021): 830–46. http://dx.doi.org/10.1177/1354856521989514.

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Although Augmented Reality (AR) scholarship is largely defined through technocentric boundary work that delineates the virtual from the real, it is nevertheless vital to consider experiential conceptualisations of AR as mediating the human–physical environment, as this makes visible for analysis specific properties that afford specific dynamics of augmented publics. We consider how AR mediates the environment in ways previous media could not, identifying four affordances of note. We name visual (dis)integrity, environmental activation, contextual pointalisation and four-dimensional place(ment), as well as reliance on digital infrastructures as sets of properties and dynamics that speak to what AR affords its users. The article first traces how the conceptualisation of AR in scholarship has yet to move past technocentric metaphors of description, adopted from the Virtuality Continuum (Milgram et al., 1995) that separates reality from mediating technologies. It then pushes media critique conceptualising AR in ways that more accurately account for lived experiences of perception. Doing so updates the metaphors used to understand AR and exposes first- and second-order affordances of AR media, which define but are not definitive of the constraints and potentials present in how the properties and dynamics of AR mediate perceptions of life. The article concludes by noting how future research can now consider definitions of AR media that centre on how perceptible spatial computation augments relations between objects, whether these are conjured from electrons, atoms or humans.

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Wang, Yan Yan, Yi Wen Yang, Xiang You, Xiao Qian Deng, Chun Fang Hu, Cong Zhu, Jun Yao Wang et al. "Ex VivoNicotine Stimulation Augments the Efficacy of Human Peripheral Blood Mononuclear Cell-Derived Dendritic Cell Vaccination via Activating Akt-S6 Pathway". Analytical Cellular Pathology 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/741487.

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Our previous studies showed thatα7 nicotinic acetylcholine receptor (nAchR) agonist nicotine has stimulatory effects on murine bone marrow-derived semimature DCs, but the effect of nicotine on peripheral blood mononuclear cell- (PBMC-) derived human semimature dendritic cells (hu-imDCs) is still to be clarified. In the present study, hu-imDCs (cultured 4 days) were conferred with ex vivolower dose nicotine stimulation and the effect of nicotine on surface molecules expression, the ability of cross-presentation, DCs-mediated PBMC priming, and activated signaling pathways were determined. We could demonstrate that the treatment with nicotine resulted in increased surface molecules expression, enhanced hu-imDCs-mediated PBMC proliferation, upregulated release of IL-12 in the supernatant of cocultured DCs-PBMC, and augmented phosphorylation of Akt and ribosomal protein S6. Nicotine associated with traces of LPS efficiently enhanced endosomal translocation of internalized ovalbumin (OVA) and increased TAP-OVA colocalization. Importantly, the upregulation of nicotine-increased surface molecules upregulation was significantly abrogated by the inhibition of Akt kinase. These findings demonstrate thatex vivonicotine stimulation augments hu-imDCs surface molecules expression via Akt-S6 pathway, combined with increased Ag-presentation result in augmented efficacy of DCs-mediated PBMC proliferation and Th1 polarization.

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Xiao, Huajuan, Yang Xu, Shan Cui e Jin-Hui Wang. "Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory". International Journal of Molecular Sciences 25, n.º 2 (5 de janeiro de 2024): 711. http://dx.doi.org/10.3390/ijms25020711.

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Memory traces are believed to be broadly allocated in cerebral cortices and the hippocampus. Mutual synapse innervations among these brain areas are presumably formed in associative memory. In the present study, we have used neuronal tracing by pAAV-carried fluorescent proteins and neuroligin-3 mRNA knockdown by shRNAs to examine the role of neuroligin-3-mediated synapse formation in the interconnection between primary associative memory cells in the sensory cortices and secondary associative memory cells in the hippocampus during the acquisition and memory of associated signals. Our studies show that mutual synapse innervations between the barrel cortex and the hippocampal CA3 region emerge and are upregulated after the memories of associated whisker and odor signals come into view. These synapse interconnections are downregulated by a knockdown of neuroligin-3-mediated synapse linkages. New synapse interconnections and the strengthening of these interconnections appear to endorse the belief in an interaction between the hippocampus and sensory cortices for memory consolidation.

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Garcia-Torales, Guillermo, Hector Hugo Torres-Ortega, Ruben Estrada-Marmolejo, Anuar B. Beltran-Gonzalez e Marija Strojnik. "Thermal Bed Design for Temperature-Controlled DNA Amplification Using Optoelectronic Sensors". Sensors 24, n.º 21 (31 de outubro de 2024): 7050. http://dx.doi.org/10.3390/s24217050.

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Loop-Mediated Isothermal Loop-Mediated Isothermal Amplification (LAMP) is a widely used technique for nucleic acid amplification due to its high specificity, sensitivity, and rapid results. Advances in microfluidic lab-on-chip (LOC) technology have enabled the integration of LAMP into miniaturized devices, known as μ-LAMP, which require precise thermal control for optimal DNA amplification. This paper introduces a novel thermal bed design using PCB copper traces and FR−4 dielectric materials, providing a reliable, modular, and repairable heating platform. The system achieves accurate and stable temperature control, which is critical for μ-LAMP applications, with temperature deviations within ±1.0 °C. The thermal bed’s performance is validated through finite element method (FEM) simulations, showing uniform temperature distribution and a rapid thermal response of 2.5 s to reach the target temperature. These results highlight the system’s potential for applications such as disease diagnostics, biological safety, and forensic analysis, where precision and reliability are paramount.

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Ghosh, Souvik, Meric Ataman, Maciej Bak, Anastasiya Börsch, Alexander Schmidt, Katarzyna Buczak, Georges Martin et al. "CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis". Nucleic Acids Research 50, n.º 6 (2 de março de 2022): 3096–114. http://dx.doi.org/10.1093/nar/gkac114.

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Abstract The mammalian cleavage factor I (CFIm) has been implicated in alternative polyadenylation (APA) in a broad range of contexts, from cancers to learning deficits and parasite infections. To determine how the CFIm expression levels are translated into these diverse phenotypes, we carried out a multi-omics analysis of cell lines in which the CFIm25 (NUDT21) or CFIm68 (CPSF6) subunits were either repressed by siRNA-mediated knockdown or over-expressed from stably integrated constructs. We established that >800 genes undergo coherent APA in response to changes in CFIm levels, and they cluster in distinct functional classes related to protein metabolism. The activity of the ERK pathway traces the CFIm concentration, and explains some of the fluctuations in cell growth and metabolism that are observed upon CFIm perturbations. Furthermore, multiple transcripts encoding proteins from the miRNA pathway are targets of CFIm-dependent APA. This leads to an increased biogenesis and repressive activity of miRNAs at the same time as some 3′ UTRs become shorter and presumably less sensitive to miRNA-mediated repression. Our study provides a first systematic assessment of a core set of APA targets that respond coherently to changes in CFIm protein subunit levels (CFIm25/CFIm68). We describe the elicited signaling pathways downstream of CFIm, which improve our understanding of the key role of CFIm in integrating RNA processing with other cellular activities.

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Tickoo, Asha. "An emergent English-mediated identity and a Chinese variety of WE". Pragmatics and Society 11, n.º 1 (30 de março de 2020): 70–95. http://dx.doi.org/10.1075/ps.17023.tic.

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Abstract This paper will document an English-learning influenced transformation of self, as a shared experience amongst a community of its Chinese users. The study examines 84 English narratives on the English language learning (ELL) experience of undergraduate L1 speakers of Mandarin at three proficiency levels: Year II, Year III and Year IV. Identity, expressed in learners’ positioning on ELL, is assessed in its explicit, propositionally represented form, and its linguistically marked implicit counterpart. Implicit positioning is examined at the macro-discoursal level by acknowledging the choice of the narrative configuration, and therefore the perceptual mould, adopted for the capture of the ELL experience. It is also assessed at the micro-discoursal, sentential level in (1) the registered sense of agency over the learning, (2) the assumed responsibility for statements about the learning, and (3) the character of definition given to the learning. The cross-proficiency level assessment will show that overt and implicit positioning are in consonance in capturing a gradual adoption of an English-mediated access to the world, with resulting altered affiliations, affinities, and sense of being. The study traces the emergence of a Chinese community uniquely defined, in its own perception, by the use of the English language; hence its significance to the World Englishes enterprise.

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Trottier, Daniel. "Scandal mining: political nobodies and remediated visibility". Media, Culture & Society 40, n.º 6 (25 de outubro de 2017): 893–908. http://dx.doi.org/10.1177/0163443717734408.

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This article considers the 2015 federal election in Canada as the emergence of seemingly citizen-led practices whereby candidates’ past missteps are unearthed and distributed through social and news media channels. On first pass, these resemble citizen-led engagements through digital media for potentially unmappable political goals, given the dispersed and either non-partisan or multi-partisan nature of these engagements. By bringing together journalistic accounts and social media coverage alongside current scholarship on citizenship and visibility, this case study traces the possibility of political accountability and the political weaponisation of mediated visibility through the targeted extraction of candidate details from dispersed profiles, communities and databases.

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Casaqui, Vander. "Publicidade, marcas e análise do ethos". Comunicação Mídia e Consumo 2, n.º 4 (17 de setembro de 2008): 103–22. http://dx.doi.org/10.18568/cmc.v2i4.38.

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Este artigo apresenta uma abordagem epistemológica por meio da ótica do ethos publicitário. Destacamos as estratégias de modulação enunciativa, que projetam traços de caráter e corporalidade, na negociação simbólica entre o anunciante e seu público-alvo. Esse processo é mediado pela comunicação das marcas. Palavras-chave: Publicidade; ethos; marcas; semiótica; linguagem. ABSTRACT This article presents an epistemologic approach through the optical of the advertising ethos. We detach the strategies of the enunciate modulations, that project traces of character and shape, on the symbolical negotiation between the announcer and his target public. This process is mediated by the brands communication. Keywords: Advertising; ethos; brands; semiotics; language.

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Leong, Ka Wai, Fangyan Yu e G. Mike Makrigiorgos. "Mutation enrichment in human DNA samples via UV-mediated cross-linking". Nucleic Acids Research 50, n.º 6 (14 de dezembro de 2021): e32-e32. http://dx.doi.org/10.1093/nar/gkab1222.

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Abstract Detection of low-level DNA mutations can reveal recurrent, hotspot genetic changes of clinical relevance to cancer, prenatal diagnostics, organ transplantation or infectious diseases. However, the high excess of wild-type (WT) alleles, which are concurrently present, often hinders identification of salient genetic changes. Here, we introduce UV-mediated cross-linking minor allele enrichment (UVME), a novel approach that incorporates ultraviolet irradiation (∼365 nm UV) DNA cross-linking either before or during PCR amplification. Oligonucleotide probes matching the WT target sequence and incorporating a UV-sensitive 3-cyanovinylcarbazole nucleoside modification are employed for cross-linking WT DNA. Mismatches formed with mutated alleles reduce DNA binding and UV-mediated cross-linking and favor mutated DNA amplification. UV can be applied before PCR and/or at any stage during PCR to selectively block WT DNA amplification and enable identification of traces of mutated alleles. This enables a single-tube PCR reaction directly from genomic DNA combining optimal pre-amplification of mutated alleles, which then switches to UV-mediated mutation enrichment-based DNA target amplification. UVME cross-linking enables enrichment of mutated KRAS and p53 alleles, which can be screened directly via Sanger sequencing, high-resolution melting, TaqMan genotyping or digital PCR, resulting in the detection of mutation allelic frequencies of 0.001–0.1% depending on the endpoint detection method. UV-mediated mutation enrichment provides new potential for mutation enrichment in diverse clinical samples.

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Zhou, Alvin, e Aimei Yang. "The Longitudinal Dimension of Social-Mediated Movements: Hidden Brokerage and the Unsung Tales of Movement Spilloverers". Social Media + Society 7, n.º 3 (julho de 2021): 205630512110475. http://dx.doi.org/10.1177/20563051211047545.

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This study traces the retweet networks among a group of movement spilloverers spanning across five social-mediated movements (i.e., People’s Climate March, Women’s March, #GrabYourWallet, March for Our Lives, and #StoptheBans) and examines the longitudinal inter-movement dynamics. Our analysis reveals that movement spillover is a widespread phenomenon existing in ideologically compatible movements across issue areas and lasted over 5 years. We also found that movement spilloverers functioned as relationship brokers both within their original movement networks and across movements. We identified four types of brokers based on their movement memberships and flows of information, and explored the unique characteristics of these brokers. We found that itinerants and representatives are exceptionally influential among the general public and media, whereas coordinators commend considerable influence among politicians. Representatives are most effective when influencing the activist community. Theoretical and practical implications are also discussed.

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Merrill, Samuel. "Remembering like a state: Surveillance databases, digital activist traces and the repressive potential of mediated prospective memory". Memory Studies 17, n.º 5 (outubro de 2024): 1177–94. http://dx.doi.org/10.1177/17506980241262187.

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Departing from personal memories of protests in London and Berlin, in this article I make space within the memory-activism nexus to consider how contemporary activists are remembered by that which they conventionally target: the state. To do this, I first recount existing understandings of that nexus and the position of the state therein. I then emphasise how states remember activists via police surveillance databases before discussing the digital activist traces held in such databases via the concept of mediated prospective memory. Thereafter, I empirically ground these conceptual contributions via a discussion of the surveillance databases used in the United Kingdom and Germany and the growing adoption of automated facial recognition technology in these countries. This discussion relies on the work of police monitoring groups whose activism contributes, alongside the various actions of the state and its agencies that I foreground, to the complexity of the memory-activism nexus.

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Loffler, Sylvia Grune, Carlos Leiva, Exequiel Scialfa, Leandro Redondo, Mónica Florin-Christensen, Mara Martínez, Graciela Romero e Bibiana Brihuega. "Detection of Pathogenic Leptospiral DNA Traces in Canine Sera Serum Samples by Loop Mediated Isothermal Amplification (LAMP)". Immunology and Infectious Diseases 4, n.º 4 (dezembro de 2016): 39–43. http://dx.doi.org/10.13189/iid.2016.040401.

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Akhmerov, H. U. "About traces of functional activity of acupuncture points and meridians after a person's death". Kazan medical journal 75, n.º 3 (15 de março de 1994): 230–31. http://dx.doi.org/10.17816/kazmj89938.

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A doctor brought up in the traditions of the Pavlovian school is inclined to consider all physiological manifestations of the human body subordinate to the regulatory influences of the nervous system. At the same time, they completely ignore the fact that both in ontogenesis and in phylogeny, the nervous system appears quite late and that up to this point other regulatory mechanisms operate quite effectively in the body, precisely determining the interaction of various tissues and rudiments of organs with each other. These mechanisms are associated with direct, not yet mediated by the nervous system, energy-informational interactions of organs and tissues. It is believed that with the emergence of the nervous system, the former mechanisms of regulation fade into the background, manifesting themselves only in special phenomena that are difficult to explain from the standpoint of pure nervism. Such phenomena include acupuncture.

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Bowen, John R. "On the Political Construction of Tradition: Gotong Royong in Indonesia". Journal of Asian Studies 45, n.º 3 (maio de 1986): 545–61. http://dx.doi.org/10.2307/2056530.

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The idea of “mutual assistance” (gotong royong) in Indonesia has been the basis for political discourse concerning the nature of authority, the characteristics of village society, and the legitimacy of demands for labor by the state. This article traces the way in which both changing political ideologies and state-village relations have been mediated by the term gotong royong, and suggests that its multiple meanings have been central to its semantic, political, and economic roles. Local interpretations of national doctrine and reactions to state policy are examined in two cases: East Java and Gayo (Aceh). The wide variety of local strategies is perceived as depending on preexisting political traditions and power relations vis-à-vis the state.

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Caplan, Robyn, e danah boyd. "Isomorphism through algorithms: Institutional dependencies in the case of Facebook". Big Data & Society 5, n.º 1 (janeiro de 2018): 205395171875725. http://dx.doi.org/10.1177/2053951718757253.

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Algorithms and data-driven technologies are increasingly being embraced by a variety of different sectors and institutions. This paper examines how algorithms and data-driven technologies, enacted by an organization like Facebook, can induce similarity across an industry. Using theories from organizational sociology and neoinstitutionalism, this paper traces the bureaucratic roots of Big Data and algorithms to examine the institutional dependencies that emerge and are mediated through data-driven and algorithmic logics. This type of analysis sheds light on how organizational contexts are embedded into algorithms, which can then become embedded within other organizational and individual practices. By investigating technical practices as organizational and bureaucratic, discussions about accountability and decision-making can be reframed.

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Damjanov, Katarina, e David Crouch. "Global media cultures among the stars: Formations of celebrity in outer space". International Journal of Cultural Studies 21, n.º 5 (24 de abril de 2017): 553–68. http://dx.doi.org/10.1177/1367877917705915.

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The space age launched its own breed of celebrity onto the world stage. From Sputnik onwards, exploration of outer space has endowed media cultures with many spectacular events and prominent heroes, extending the currencies of fame beyond the planet. Under the rubric of ‘space celebrity’, this article gathers those famous people, animals and technologies that have been sent as our envoys into the unknowns of space, framing their exploits as a distinctive register of our mediated public culture and its global provisions. It traces the historical emergence and unfolding of space celebrity and explores the ways in which its human and non-human protagonists shape the extra-planetary horizon of our common world.

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Kaźmierczak, Marta. "The Tower of Babel or Ivory Tower? The Reception of Western Translation Research in Russian-Language Translation Studies – a Reconnaissance". Przekładaniec, Special Issue 2/2022 (2022): 7–52. http://dx.doi.org/10.4467/16891864epc.22.009.16929.

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The aim of this article is to survey which texts and authors representing Western translation studies have been translated into Russian over the last seven decades and to describe the dynamics of the emergence of these translations as well as possible agendas behind their selection. It also traces, on a partial corpus, to what extent Russian translation scholars tend to cite and quote Western ones. The findings lead to a tentative conclusion that so far TS knowledge has been transferred mainly by unfrequent references to original publications and by way of mediated accounts (reviews, textbook summaries), while translations of particular studies have only recently begun appearing on a wider scale, their impact as yet uncertain.

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Brønd, Thomas Vladimir. "Islam og revolution". Tidsskrift for Islamforskning 7, n.º 1 (5 de fevereiro de 2017): 12. http://dx.doi.org/10.7146/tifo.v7i1.25310.

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This article deals with the ways in which Islam is put to use by the Syrian regime and its opposition in the Syrian Uprising. By applying anthropological theory about politics of immediation and political theory about ideologies to a specific case – namely bombings in Kafer Suseh in Damascus in December 2011 – the article illustrates how horrific images in the conflict are mediated as part of distinctive political projects. The article traces the work of anti-regime activists on the Internet and on TV as well as that of pro-regime representatives in order to understand the peculiar scapegoating processes that followed in the hours after the bombings. In effect, a certain dynamic of ideological mediation is proposed in which social, historical and political presuppositions are suppressed. Resurfacing the historical conditions of mediation gives a better understanding of how horrific events as the one in the case are mediated. On a fundamental level, the case and its analysis indicates how politics of immediation and ideology intertwine in battles over Islam and its future role in Syria.

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Syrovets, Tatiana, Almut Schüle, Marina Jendrach, Berthold Büchele e Thomas Simmet. "Ciglitazone Inhibits Plasmin-Induced Proinflammatory Monocyte Activation via Modulation of p38 MAP Kinase Activity". Thrombosis and Haemostasis 88, n.º 08 (2002): 274–81. http://dx.doi.org/10.1055/s-0037-1613198.

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SummaryPlasmin triggers chemotaxis and NF-κBand AP-1-mediated proinflammatory gene expression in human peripheral monocytes (PM). Compared with macrophages and dendritic cells, PM express mainly the peroxisome proliferator-activated receptor (PPAR) γ and traces of PPARα as detected by semiquantitative RT-PCR and immunoblotting. The PPARγ agonist ciglitazone, but not the PPARα agonist clofibric acid, concentration-dependently inhibited the plasmin-, but not the FMLP-induced PM chemotaxis. Similarly, release of interleukin (IL)-1α, IL-1β and tumor necrosis factor (TNF)-α from plasmin-stimulated PM was concentration-dependently inhibited by ciglitazone, but not by clofibric acid, while the LPS-induced TNF-α release remained unaffected by any of both PPAR agonists. Ciglitazone activates PPARγ as shown by a novel surface plasmon resonance analysis and inhibits the plasmin-induced activation of NF-κB and AP-1. It also inhibits p38 MAPK phosphorylation essential for the plasmin-induced PM chemotaxis and gene activation. Thus, activation of PPARγ by ciglitazone may allow controling of the plasmin-mediated recruitment and activation of PM at sites of inflammation.

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Terehovich, V. N., e E. V. Nimande. "ESSENCE OF CRIMINALISTIC TACTICS". Theory and Practice of Forensic Science and Criminalistics 18 (26 de dezembro de 2018): 35–44. http://dx.doi.org/10.32353/khrife.2018.04.

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Performing of criminal procedure activities during pre-trial procedure (investigative activities) in order to find and fix (according to criminal procedure) traces linked to criminal act event, compiling and checking of necessary evidence of corpus delicti presence and other circumstances linked to this event forms essence of any investigation of criminal offence. Modern system of investigative actions in Criminal procedure in Latvia is restricted to the following list of investigative actions: interrogation, questioning, face-to-face interrogation, inspection, exhumation, examination, investigative experiment, checking evidence in place, identification, search, seizure and expertise. Besides the list of investigative activities in Latvia there are also normative regulations about general requirements for their performing. Apart from expertise all investigative actions allow direct perception and fixation of criminal act traces by a person realizing investigation. Expertise is based on the mediated knowledge acquisition about criminal act traces. A person performing criminal investigation this knowledge receives with the help of an expert producing special study. The theoretical bases of all investigative actions are modern theories of observation, experiment, comparison, measurement and modeling. Type and content of a separate investigative action which is determined normatively in a given state is the determining factor in the designation and definition of its tactics. Totality of tactic regularities of performing specific investigative activities is forming criminalistic tactics. Therefore criminalistic tactics can be defined as chapter of special part of criminalistic theory describing and explaining regularities of performing investigative activities. Attempts by some authors to "embed" into criminalistic terminology such terms as judicial tactics, prosecutor's tactics, advocacy tactics and other similar "novels" have nothing to do with criminal investigation within the modern criminal procedure and do not belong to criminalistics. Use of such terms in scientific papers on criminalistics should be evaluated as obstruction of criminalistic terminology.

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Artigos de revistas sobre o tema "Mediated traces"

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