Literatura científica selecionada sobre o tema "Mécanisme antibactérien"
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Artigos de revistas sobre o assunto "Mécanisme antibactérien"
Bouyahya, A., Y. Bakri, A. Et-Touys, A. Talbaoui, A. Khouchlaa, S. Charfi, J. Abrini e N. Dakka. "Résistance aux antibiotiques et mécanismes d’action des huiles essentielles contre les bactéries". Phytothérapie 16, S1 (dezembro de 2018): S173—S183. http://dx.doi.org/10.3166/phyto-2019-0147.
Texto completo da fonteZhang, Jin, Aigin Wang, Chengzhi Zhang e Yuting Wang. "Agents antibactériens inorganiques utilisés dans les matériaux de construction : mécanismes d’action, sécurité et effet à long terme". Annales de chimie Science des Matériaux 39, n.º 1-2 (28 de junho de 2015): 93–105. http://dx.doi.org/10.3166/acsm.39.93-105.
Texto completo da fonteVanessa, Soppo Lobe Charlotte, Moïse Henri Julien Nko’o, Foumane Maniepi Ngoupiho Jacqueline Saurelle, Benga Mekoulou Félicité, Ndongo Martin Nyangono, Minyem Ngombi Aude Perine, Emanda Ekoudi Martin, Toukam Michel, Nnanga Nga e Ze Minkande Jacqueline. "Composition chimique et activité antimicrobienne sur des souches responsables d’infections cutanées de l’extrait méthanoïque d’écorces de Vernonia conferta (Asteraceae)". Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB) 2, n.º 3 (20 de dezembro de 2023). http://dx.doi.org/10.57220/jatpb.v2i3.111.
Texto completo da fonteTeses / dissertações sobre o assunto "Mécanisme antibactérien"
Galanth, Cécile. "Etude du mécanisme d'action d'une peptide cationique antibactérien, la dermaseptine B2". Paris 6, 2009. http://www.theses.fr/2009PA066047.
Texto completo da fonteVassiliadis, Gaëlle. "Biosynthèse et mécanisme d'action des microcines sidérophores, peptides antibactériens sécrétés par les entérobactéries". Paris 6, 2009. http://www.theses.fr/2009PA066235.
Texto completo da fonteFlaugnatti, Nicolas. "Le système de sécrétion de type VI : caractérisation et mécanisme de transport de Tle1, un effecteur antibactérien de type phospholipase". Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0204.
Texto completo da fonteBacteria do not live alone in their environment; they cooperate but also compete for niches and resources. The Type VI secretion system (T6SS) is one of the key players in the bacterial warfare by delivering anti-bacterial effectors directly into competitor cells. The T6SS is a macromolecular structure: A membrane complex (MC) anchored in the envelope recruits an assembly platform for a contractile tail structure. The tail is a tube wrapped by a sheath and topped by a needle spike called VgrG. The tail assembles in an elongated conformation. Upon contact with a target cell, the contraction of the sheath propels the inner tube, the spike and the toxins toward target cells. The goal of my PhD work was to identify T6SS toxins and to understand how they are selected by the EAEC T6SS. We have characterized Tle1, an antibacterial effector with phospholipase A1 (PLA1) activity, responsible for the antibacterial activity of EAEC T6SS. Self-protection of the producing cell is assured by an outer membrane lipoprotein, Tli1. We further showed that Tle1 interacts directly with the C-terminal extension domain of VgrG to allow subsequent delivery into target bacteria. We succeeded to purify the complex and obtain a 3D model at low resolution of the complex by electron microscopy after negative staining. The toxin interacts with the tip of the needle spike to be transported from the producing cell to the target cell
Awassa, Jazia. "Mécanismes antibactériens des hydroxydes doubles lamellaires à base de zinc". Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0155.
Texto completo da fonteLayered double hydroxides (LDH) are solid compounds constituted by the stacking of divalent M(II) and trivalent M(III) metal hydroxide sheets separated by an interlayer of anions and water molecules. Due to the versatility of LDH in terms of their tunable physico-chemical properties, a growing interest arises for investigating their different antibacterial activity mechanisms. This thesis work aims at studying the different proposed hypotheses explaining the antibacterial effect of pristine zinc-based LDHs: (1) direct interactions between the surface of LDH and bacterial cell walls, (2) release of constituent divalent metal ions, (3) generation of reactive oxygen species (ROS). First a global investigation was performed to determine the different physico-chemical parameters influencing the antibacterial activity of pristine M(II)Al(III) LDHs (M= Zn, Cu, Ni, Co, Mg). The antimicrobial effect of LDHs against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria was linked in the first place to the nature of divalent metal itself, and to the amount of released M2+aq ions into the culture media in the second place. This effect was more easily identified in Zn(II)-based LDHs possessing the strongest antibacterial activity and whose antibacterial properties depended on their release profile of Zn2+aq ions (Mechanism 2) initially controlled by the different physico-chemical parameters. Moreover, the direct contact mechanism (Mechanism 1) was validated for Zn(II)-based LDHs by comparing the antibacterial activity of micron-sized LDHs against S. aureus to that of LDH nanoparticles (NPs) exhibiting a greater antibacterial effect. The presence of specific surface interactions between Zn(II)-based LDHs and the cell wall of S. aureus was further validated by atomic force microscopy-based force spectroscopy (AFM-FS). The enhancement of the antibacterial properties of Zn(II)-based LDH NPs by ROS generation (Mechanism 3) in presence of UVA light was also assessed. After providing experimental evidences about the three suggested mechanisms, the role of each mechanism contributing to the antibacterial activity of Zn(II)-based LDHs in different antibacterial tests assays was determined
Costa, André Sónia Maria. "Mécanisme d’action et relation structure-fonction des temporines SH, une famille de peptides antimicrobiens de la peau d’Amphibien". Electronic Thesis or Diss., Paris 6, 2015. http://www.theses.fr/2015PA066757.
Texto completo da fonteAntimicrobial peptides (AMPs) are key effectors of innate immunity that provide a first line of defense against pathogens. These peptides typically have broad-spectrum antimicrobial activity and act rapidly and efficiently through a membranolytic mechanism that limits the development of resistance. With the emergence of resistant microorganisms, a major public health concern, AMPs therefore represent good candidates for the therapeutic development of new and valuable compounds. During my thesis, I focused on AMP from amphibian skin. Firstly, five potential AMP precursors were identified from the frog Trachycephalus resinifictrix using a combined biochemical /molecular biology approach. Among these, two correspond to cathelicidin precursors, two were similar to the “AMP/opioid“ precursors (T. venulosus), and one was similar to hylareleasin precursors (Hyla simplex). Secondly, I was interested in temporins SH, small AMPs previously isolated from the frog Pelophylax saharicus by our team. We performed structure-activity relationship studies on temporin-SHf, the smallest linear amphibian AMP known to date (8 residues). This allowed us to identify several potent analogs with a higher therapeutic index. Furthermore, we also thoroughly studied the mechanism of action of temporin-SHa and its analogs. We showed that temporins act rapidly through a membranolytic mechanism, leading to bacterial membrane disruption (detergent-like effect). For Leishmania promastigotes, the same membranolytic mechanism was observed with also a temporin-induced apoptosis that takes place at higher peptide concentrations. Finally, biophysical and biological techniques enabled us to structurally and functionally characterize temporin-SHe. Like temporin-SHa, this peptide displayed a broad-spectrum activity including Leishmania. Our results indicate that temporins could serve as lead compounds to develop a new class of therapeutic anti-infective peptides
Chan, Alice. "Structure et Mécanisme de la Quinolinate Synthase : enzyme à centre [4Fe-4S]2+ et cible d'agents antibactériens". Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV036.
Texto completo da fonteThe Nicotinamide Adenine Dinucleotide (NAD) is a key cofactor essential for cellular metabolism. Synthesized from quinolinic acid (QA) in all living organisms, NAD biosynthesis is different between eucaryotes and procaryotes. Indeed, most of eukaryotes produce QA from L-tryptophan, whereas most of prokaryotes and plants synthesize QA by the concerted action of 2 enzymes: L-aspartate oxydase (NadB), an FAD enzyme, which catalyzes L-Aspartate oxidation to form iminoaspartate (IA) while quinolinate synthetase (NadA) allows condensation between IA and Dihydroxyacetone Phosphate (DHAP) to produce QA. Besides this « de novo » pathway, most eukaryotes and some bacteriae have a salvage pathway which allows NAD synthesis from nutrients and metabolites of NAD degradation in order to maintain a correct pool of NAD in the cell. However, some pathogens like Mycobacterium leprae, Helicobacter pylori do not possess this pathway. As a consequence, NadA represents a very attractive target for designing specific antibacterial agents since it does not exist in Human.NadA is the only metalloenzyme of NAD de novo biosynthesis whose molecular mechanism and tridimensional structure with its [4Fe-4S]2+ cluster are unknown. Using substrate and intermediate analogues, we have been able to understand better NadA mechanism, especially [4Fe-4S]2+ cluster role in catalysis. Moreover, we proposed the first in vitro and in vivo inhibitor of NadA : the 4,5 Dithiohydroxyphtalic Acid (DTHPA) which gave us basis to design powerful and specific NadA inhibitors thanks to a structure-activity relationship study. Besides, we resolved the first X-rays structure of NadA under its holoprotein form. Datas we extracted from it helped us greatly to understand NadA mechanism
Ebran, Nathalie. "Propriétés antibactériennes et « formeur de pores » de protéines du mucus épidermique. Implication dans les mécanismes de défense des poissons". Rouen, 1999. http://www.theses.fr/1999ROUES077.
Texto completo da fonteJoanne, Pierre. "Les plasticines, peptides antibactériens de la peau de grenouille : versatilité fonctionnelle, adaptabilité des structures et des interactions membranaires". Paris 6, 2009. http://www.theses.fr/2009PA066464.
Texto completo da fonteBrunel, Frédéric. "Synthèse, conception et élaboration de nouveaux systèmes dérivés de liquides ioniques antibactériens à base de phosphonium". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4087.
Texto completo da fonteA recent WHO report warns the health authorities about the emergence of new bacterial resistances and the development of multi-resistant strains against current antibiotics treatments. The growth of those resistances is due to several factors. The hospital environment concentrates a significant use of antibiotics and disinfectant representing a favorable ground for bacterial resistance development. Among them the Staphylococcus aureus and its methicillin resistant strain (MRSA) represent a crucial issue in care environments and is a major cause of hospital acquired infections. In this context, it is essential to develop new antibacterial agents to fight against these bacteria. Ionic liquid are low melting point salts, they show significant antibacterial properties. However, the fact that the mechanisms of action of their bactericidal effect have not been established yet constitutes a major obstacle to their development as bactericidal agents. Thus, we propose to synthetize ammonium- and phosphonium-based di-cationic ionic liquids in order to study the different structural factors that govern their antibacterial activity. Then we will develop phosphonium based ionic liquids functionalized with a fluorescent probe. By taking advantage of their spectroscopic properties we will try to observe their interactions with bacterial cells. Finally, we propose to use the phosphonium salts as surface functionalization agents in order to design surfaces with intrinsic antibacterial properties. To do so, we will use innovative methods such as conception of self-assembled monolayers or electropolymerization technics
Brunel, Frédéric. "Synthèse, conception et élaboration de nouveaux systèmes dérivés de liquides ioniques antibactériens à base de phosphonium". Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4087.
Texto completo da fonteA recent WHO report warns the health authorities about the emergence of new bacterial resistances and the development of multi-resistant strains against current antibiotics treatments. The growth of those resistances is due to several factors. The hospital environment concentrates a significant use of antibiotics and disinfectant representing a favorable ground for bacterial resistance development. Among them the Staphylococcus aureus and its methicillin resistant strain (MRSA) represent a crucial issue in care environments and is a major cause of hospital acquired infections. In this context, it is essential to develop new antibacterial agents to fight against these bacteria. Ionic liquid are low melting point salts, they show significant antibacterial properties. However, the fact that the mechanisms of action of their bactericidal effect have not been established yet constitutes a major obstacle to their development as bactericidal agents. Thus, we propose to synthetize ammonium- and phosphonium-based di-cationic ionic liquids in order to study the different structural factors that govern their antibacterial activity. Then we will develop phosphonium based ionic liquids functionalized with a fluorescent probe. By taking advantage of their spectroscopic properties we will try to observe their interactions with bacterial cells. Finally, we propose to use the phosphonium salts as surface functionalization agents in order to design surfaces with intrinsic antibacterial properties. To do so, we will use innovative methods such as conception of self-assembled monolayers or electropolymerization technics
Capítulos de livros sobre o assunto "Mécanisme antibactérien"
Goetz, Paul, e Kamel Ghedira. "Mécanisme d’action antibactérienne des huiles essentielles". In Collection Phytothérapie Pratique, 193–208. Paris: Springer Paris, 2012. http://dx.doi.org/10.1007/978-2-8178-0058-5_9.
Texto completo da fonte