Artigos de revistas: "Md07"

1

De Ridder, Chantal, Bruno David e Alberto Larrain. "Antarctic and Subantarctic echinoids from 'Marion Dufresne' expeditions MD03, MD04, MD08 and from the 'Polarstern' expedition Epos III". Bulletin du Muséum national d'histoire naturelle 14, n.º 2 (1992): 405–41. http://dx.doi.org/10.5962/p.292218.

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Voelker, A. H. L., T. Rodrigues, R. Stein, J. Hefter, K. Billups, D. Oppo, J. McManus e J. O. Grimalt. "Variations in mid-latitude North Atlantic surface water properties during the mid-Brunhes: Does Marine Isotope Stage 11 stand out?" Climate of the Past Discussions 5, n.º 3 (3 de junho de 2009): 1553–607. http://dx.doi.org/10.5194/cpd-5-1553-2009.

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Abstract. New planktonic stable isotope and ice-rafted debris records from three core sites in the mid-latitude North Atlantic (IODP Site U1313, MD01-2446, MD03-2699) are combined with records of ODP Sites 1056/1058 and 980 to reconstruct hydrographic conditions during the middle Pleistocene spanning Marine Isotope Stages (MIS) 9–14 (300–540 ka). Together the study sites reflect western and eastern basin boundary currents as well as north to south transect sampling of subpolar and transitional water masses. Planktonic δ18O records indicate that during peak interglacial MIS 9 and 11 hydrographic conditions were similar among all the sites with relative stable conditions and confirm prolonged warmth during MIS 11c also for the mid-latitudes. Sea surface temperature (SST) reconstructions further reveal that in the mid-latitude North Atlantic MIS 11c is associated with two plateaus, the younger one of which is slightly warmer. Enhanced subsurface northward heat flux in the eastern boundary current system, especially during early MIS 11c, is denoted by the presence of tropical planktonic foraminifer species. MIS 13 was generally colder and more variable than the younger interglacials. The greatest differences between the sites existed during the glacial inceptions and glacials. Then a north-south trending hydrographic front separated the nearshore and offshore waters off Portugal. While offshore waters originated from the North Atlantic Drift as indicated by the similarities between the records of IODP Site U1313, ODP Site 980 and MD01-2446, nearshore waters as recorded in core MD03-2699 derived from the Azores Current and thus the subtropical gyre. A strong Azores Current influence is seen especially during MIS 12, when SST dropped significantly only during the Heinrich-type ice-rafting event at the onset of Termination V. Given the subtropical overprint on Portuguese nearshore sites such as MD03-2699 and MD01-2443 caution needs to be taken to interpret their records as basin-wide climate signals.

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Voelker, A. H. L., T. Rodrigues, K. Billups, D. Oppo, J. McManus, R. Stein, J. Hefter e J. O. Grimalt. "Variations in mid-latitude North Atlantic surface water properties during the mid-Brunhes (MIS 9–14) and their implications for the thermohaline circulation". Climate of the Past 6, n.º 4 (27 de agosto de 2010): 531–52. http://dx.doi.org/10.5194/cp-6-531-2010.

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Abstract. Stable isotope and ice-rafted debris records from three core sites in the mid-latitude North Atlantic (IODP Site U1313, MD01-2446, MD03-2699) are combined with records of ODP Sites 1056/1058 and 980 to reconstruct hydrographic conditions during the middle Pleistocene spanning Marine Isotope Stages (MIS) 9–14 (300–540 ka). Core MD03-2699 is the first high-resolution mid-Brunhes record from the North Atlantic's eastern boundary upwelling system covering the complete MIS 11c interval and MIS 13. The array of sites reflect western and eastern basin boundary current as well as north to south transect sampling of subpolar and transitional water masses and allow the reconstruction of transport pathways in the upper limb of the North Atlantic's circulation. Hydrographic conditions in the surface and deep ocean during peak interglacial MIS 9 and 11 were similar among all the sites with relative stable conditions and confirm prolonged warmth during MIS 11c also for the mid-latitudes. Sea surface temperature (SST) reconstructions further reveal that in the mid-latitude North Atlantic MIS 11c is associated with two plateaus, the younger one of which is slightly warmer. Enhanced subsurface northward heat transport in the eastern boundary current system, especially during early MIS 11c, is denoted by the presence of tropical planktic foraminifer species and raises the question how strongly it impacted the Portuguese upwelling system. Deep water ventilation at the onset of MIS 11c significantly preceded surface water ventilation. Although MIS 13 was generally colder and more variable than the younger interglacials the surface water circulation scheme was the same. The greatest differences between the sites existed during the glacial inceptions and glacials. Then a north – south trending hydrographic front separated the nearshore and offshore waters off Portugal. While offshore waters originated from the North Atlantic Current as indicated by the similarities between the records of IODP Site U1313, ODP Site 980 and MD01-2446, nearshore waters as recorded in core MD03-2699 derived from the Azores Current and thus the subtropical gyre. Except for MIS 12, Azores Current influence seems to be related to eastern boundary system dynamics and not to changes in the Atlantic overturning circulation.

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Oida, Yasuhisa, Began Gopalan, Ryo Miyahara, Satoshi Inoue, Cynthia D. Branch, Abner M. Mhashilkar, E. Lin et al. "Sulindac enhances adenoviral vector expressing mda-7/IL-24–mediated apoptosis in human lung cancer". Molecular Cancer Therapeutics 4, n.º 2 (1 de fevereiro de 2005): 291–304. http://dx.doi.org/10.1158/1535-7163.291.4.2.

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Abstract Several studies have shown antitumor activities of the melanoma differentiation–associated gene 7 (mda-7) and the nonsteroidal anti-inflammatory drug sulindac when used as a monotherapies against a wide variety of human cancers. However, the combined effects of mda-7 and sulindac have not previously been tested. Therefore, we tested the antitumor activity of an adenoviral vector expressing mda-7 (Ad-mda7) in combination with sulindac against non–small cell lung cancer cells in vitro and in vivo. When treated with Ad-mda7 in combination with sulindac, human lung cancer cells (A549 and H1299) underwent growth suppression resulting in apoptosis. The growth inhibition induced by Ad-mda7 in combination with sulindac was significantly greater than that observed with Ad-mda7 or sulindac alone. Furthermore, the degree of growth inhibition induced using this combination was dose-dependent for sulindac. Treatment with Ad-mda7 in combination with sulindac had no growth inhibitory effects on human normal lung (CCD-16) fibroblasts. We then investigated the mechanism by which sulindac enhances Ad-mda7-mediated apoptosis. Sulindac increased expression of ectopic MDA-7 protein in tumor cells, thereby increasing the expression of downstream effectors RNA-dependent protein kinase, p38MAPK, caspase-9, and caspase-3 and enhancing apoptosis of non–small cell lung cancer cells. Pulse-chase experiments showed that the increased expression of MDA-7 protein in sulindac-treated cells was due to increased half-life of the MDA-7 protein. Finally, treatment of human lung tumor xenografts in nude mice with Ad-mda7 plus sulindac significantly suppressed growth (P = 0.001) compared with Ad-mda7 or sulindac alone. Our results show for the first time that combined treatment with Ad-mda7 plus sulindac enhances growth inhibition and apoptosis of human lung cancer cells. The increased antitumor activity observed with the combination treatment is a result of increased half-life of MDA-7 protein. Regulation of protein turnover is a heretofore-unrecognized mechanism of this nonsteroidal anti-inflammatory drug.

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Wang, Nanya, Bai Fan, Noriko Miyake, Koichi Miyake e Takashi Shimada. "A Single Intramuscular Injection of AAV-8 Vector Expressing MDA7/IL-24 Efficiently Suppresses Tumor Growth Mediated by Multiple Anti-Cancer Mechanisms In Lymphoma Model Mice." Blood 116, n.º 21 (19 de novembro de 2010): 1474. http://dx.doi.org/10.1182/blood.v116.21.1474.1474.

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Abstract Abstract 1474 Melanoma differentiation-associated gene-7/interleukin-24 (MDA7/IL-24) selectively induces apoptosis in cancer cells without harming normal cells. It also exerts immunomodulatory and anti-angiogenic effects, as well as potent antitumor bystander effects, making it an ideal candidate for use in a new anticancer gene therapy. To examine the feasibility of adeno-associated virus (AAV) vectors expressing MDA7/IL-24 in systemic cancer gene therapy for lymphoma, we generated an AAV type 8 vector expressing MDA7/IL-24 (AAV-IL24). In vitro studies showed that medium conditioned by AAV-IL24-transduced C2C12 cells induces tumor cell-specific apoptosis against murine lymphoma cell line (A20 cell). To assess the in vivo effects of muscle targeted AAV-mediated systemic delivery of MDA7/IL-24 we established a lymphoma murine model in which the A20 cells expressing luciferase gene was inoculated into the caudal vein of BALB/C. Using this lymphoma murine model, we can detect the tumor growth and metastases by a real-time in vivo imaging analyze system (IVIS). After single injection of AAV-IL24 (1.5×1011 vg/body) into the right quadriceps muscle of the lymphoma model mice, tumor cell growth was monitored by IVIS. ELISA analysis showed high level of IL-24 was detected in plasma of treated mice (263±16 ng/ml). Suppression of tumor growth was observed in AAV-IL24 injected mice compared to control GFP expressing AAV injected mice (1.3×108vs.2.6×108 photon/sec; p<0.05). Survival effect was also detected in AAV-IL24 mice (66±6 vs. 47±5 days; p<0.03). In addition, TUNEL analyses showed significant induction of tumor cell-specific apoptosis within the tumors and suppression of angiogenesis was also detected in AAV-IL24 treated mice. Finally, immune modulating activity of induction of Th1 cytokines (IL-6, TNFα, IFNγ) secretion was observed after AAV-IL24 injection. These results clearly demonstrate that continuous systemic delivery of MDA7/IL-24 can serve as an effective treatment for lymphoma. Thus, AAV type 8 vector-mediated systemic deliverY of MDA7/IL-24 represents a potentially promising new approach to treat lymphoma. Disclosures: No relevant conflicts of interest to declare.

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Waelbroeck, Claire, Sylvain Pichat, Evelyn Böhm, Bryan C. Lougheed, Davide Faranda, Mathieu Vrac, Lise Missiaen et al. "Relative timing of precipitation and ocean circulation changes in the western equatorial Atlantic over the last 45 kyr". Climate of the Past 14, n.º 9 (18 de setembro de 2018): 1315–30. http://dx.doi.org/10.5194/cp-14-1315-2018.

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Abstract. Thanks to its optimal location on the northern Brazilian margin, core MD09-3257 records both ocean circulation and atmospheric changes. The latter occur locally in the form of increased rainfall on the adjacent continent during the cold intervals recorded in Greenland ice and northern North Atlantic sediment cores (i.e., Greenland stadials). These rainfall events are recorded in MD09-3257 as peaks in ln(Ti ∕ Ca). New sedimentary Pa ∕ Th data indicate that mid-depth western equatorial water mass transport decreased during all of the Greenland stadials of the last 40 kyr. Using cross-wavelet transforms and spectrogram analysis, we assess the relative phase between the MD09-3257 sedimentary Pa ∕ Th and ln(Ti ∕ Ca) signals. We show that decreased water mass transport between a depth of ∼1300 and 2300 m in the western equatorial Atlantic preceded increased rainfall over the adjacent continent by 120 to 400 yr at Dansgaard–Oeschger (D–O) frequencies, and by 280 to 980 yr at Heinrich-like frequencies. We suggest that the large lead of ocean circulation changes with respect to changes in tropical South American precipitation at Heinrich-like frequencies is related to the effect of a positive feedback involving iceberg discharges in the North Atlantic. In contrast, the absence of widespread ice rafted detrital layers in North Atlantic cores during D–O stadials supports the hypothesis that a feedback such as this was not triggered in the case of D–O stadials, with circulation slowdowns and subsequent changes remaining more limited during D–O stadials than Heinrich stadials.

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Duong, Trang H., Lan N. Vu, Thang N. Vu, Huyen T. Nguyen e Giang V. Tong. "Effect of eggshell powder and phosphorus on growth and yield of MD7 groundnut variety in spring season in Phu Xuyen, Ha Noi". Journal of Agriculture and Development 23, n.º 02 (25 de abril de 2024): 1–13. http://dx.doi.org/10.52997/jad.2.01.2024.

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The experiment was conducted to evaluate the effect of eggshell powder and phosphorus on growth and yield of MD7 groundnut variety in the spring season in Phu Xuyen, Ha Noi. The two factor experiment was laid out in a split-plot design with three replications. The main plot consisted of three rates of eggshell powder (0, 300, 500 kg/ha). The sub-plot included three rates of phosphorus (30, 60, 90 kg/ha). The results showed that the growth and yield of plants fertilized with eggshell powder were higher than those with unfertilized eggshell powder. In addition, the growth traits and yield of MD7 groundnut variety increased with increasing phosphorus fertilizer doses from 30 kg P2O5/ha to 90 kg P 2O5/ha under the same fertilized or unfertilized eggshell powder conditions. Briefly, the results indicated that the rate of 500 kg eggshell powder/ha combined with 90 kg P2O5/ha was suitable for MD7 groundnut variety to grow, develop and produce the highest yield in the spring season in Phu Xuyen, Ha Noi.

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David, Rakefet, Hanan Itzhaki, Idit Ginzberg, Yedidya Gafni, Gad Galili e Yoram Kapulnik. "Suppression of Tobacco Basic Chitinase Gene Expression in Response to Colonization by the Arbuscular Mycorrhizal Fungus Glomus intraradices". Molecular Plant-Microbe Interactions® 11, n.º 6 (junho de 1998): 489–97. http://dx.doi.org/10.1094/mpmi.1998.11.6.489.

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A differentially displayed cDNA clone (MD17) was isolated from tobacco roots (Nicotiana tabacum cv. Xanthi-nc) infected with the arbuscular mycorrhizal (AM) fungus Glomus intraradices. The isolated DNA fragment exhibited a reduced level of expression in response to AM establishment and 90% identity with the 3′ noncoding sequence of two basic chitinases (EC 3.2.1.14) from N. tabacum. Northern (RNA) blots and Western blots (immunoblots), probed with tobacco basic chitinase gene-specific probe and polyclonal antibodies raised against the chitinase enzyme, yielded hybridization patterns similar to those of MD17. Moreover, the up-regulation of the 32-kDa basic chitinase gene expression in tobacco roots by (1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH) was less effective in mycorrhizal roots than in nonmycorrhizal controls. Suppression of endogenous basic chitinase (32-kDa) expression was also observed in transgenic mycorrhizal plants that constitutively express the 34-kDa basic chitinase A isoform. When plants were grown with an increased phosphate supply, no suppression of the 32-kDa basic chitinase was obtained. These findings indicate that during the colonization and establishment of G. intraradices in tobacco roots, expression of the basic chitinase gene is down-regulated at the mRNA level.

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Rama-Corredor, O., B. Martrat, J. O. Grimalt, G. E. López-Otalvaro, J. A. Flores e F. Sierro. "Parallelisms between sea surface temperature changes in the western tropical Atlantic (Guiana basin) and high latitude climate signals over the last 140 000 years". Climate of the Past Discussions 11, n.º 2 (2 de abril de 2015): 1143–75. http://dx.doi.org/10.5194/cpd-11-1143-2015.

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Abstract. Sea surface temperatures (SST) in the Guiana basin over the last 140 ka were obtained by measuring the C37 alkenone unsaturation index U37'k in sediment core MD03-2616 (7° N, 53° W). The resulting dataset is unique for this period in the western tropical Atlantic region. SSTs range from 25.1 to 28.9 °C, i.e. glacial-to-interglacial amplitude of 3.8 °C, which is common in tropical areas. During the last two interglacials (MIS1 and MIS5e) and warm long interstadials (MIS5d-a), the sediments studied trace rapid transmission of the climate variability from arctic-to-tropical latitudes and vice-versa. During these periods, MD03-2616 SSTs showed a remarkable parallelism with temperature changes observed in Greenland and SST records of North Atlantic cores. The last deglaciation in Guiana is particularly revealing. MIS2 stands out as the coldest period of the interval analysed, with SSTs reaching as low as 25.1 °C. It contains reminders of northern latitude events such as the Bølling-Allerød warming and the Younger Dryas cooling which ensued. These oscillations were previously documented in the δ18O of the Sajama tropical ice core and are present in Guiana with rates of ca. 6 °C ka−1 and changes of over 2 °C. During the glacial interval, significant abrupt variability is observed; e.g. oscillations of 0.5–1.2 °C during MIS3, i.e. about 30% of the maximum glacial–interglacial SST change. Nevertheless, in the MD03-2616 record it is hard to identify unambiguously either the Dansgaard–Oeschger type of oscillations described in northern latitudes or the SST drops associated with the Heinrich events characterising North Atlantic records. Although these specific events form the background of the climate variability observed, what truly shapes SSTs in Guiana is a long-term tropical response to precessional changes, which is modulated in the opposite way to polar variability. This lack of synchrony is consistent with other tropical records in locations to the north or south of Guiana and evidences an arctic-to-tropical decoupling when a substantial reduction in the Atlantic meridional overturning circulation (AMOC) takes place.

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Valsecchi, V., M. F. Sanchez Goñi e L. Londeix. "Vegetation dynamics in the Northeastern Mediterranean region during the past 23 000 yr: insight from a new pollen record from the Sea of Marmara (core MD01-2430)". Climate of the Past Discussions 8, n.º 4 (29 de agosto de 2012): 4183–221. http://dx.doi.org/10.5194/cpd-8-4183-2012.

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Abstract. High-resolution pollen analysis of core MD01-2430 from the Sea of Marmara (40°47.81′ N, 27°43.51′ E) allows us to reconstruct the vegetation response to climatic changes during the past 23 cal ka in the Northeastern Mediterranean. Variation in mesic/temperate forest cover indicates major climatic shifts connected to Heinrich Stadial 1, Bölling-Allerød, Younger Dryas and to the onset of the Holocene. Pollen-anthropogenic indicator approach was used to recognize human-induced landscape changes in the Sea of Marmara. The pollen-inferred onset of the Holocene occurs at ca. 11.5 cal ka, indicating that the Northeastern Mediterranean region represents a transitional zone where higher moisture availability supported an earlier forest expansion than the borderlands of the Aegean Sea and Black Sea. Three major forest retreats occurred during the Holocene at ca. 9.2, 5.5, and 2.1 cal ka while a weaker forest setback was detected at 7.9 cal ka. The Holocene forest setbacks are in phase with previously published alkenone-inferred sea-surface temperature decreases in the Sea of Marmara (core MD01-2430) reconstructed from the same archive. Our new pollen record testifies the sensitivity of Mediterranean forests to changes in moisture availability which is driven by changes in high-latitude climate drivers (North Atlantic Oscillations and/or Siberian High).

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Ozyurek, H., H. Turker, O. Kayacik, O. F. Aydin e M. K. Onar. "MDP07 Segmental myoclonus: a case report with video documentation". European Journal of Paediatric Neurology 11 (setembro de 2007): 43. http://dx.doi.org/10.1016/s1090-3798(08)70404-5.

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12

Rama-Corredor, O., B. Martrat, J. O. Grimalt, G. E. López-Otalvaro, J. A. Flores e F. Sierro. "Parallelisms between sea surface temperature changes in the western tropical Atlantic (Guiana Basin) and high latitude climate signals over the last 140 000 years". Climate of the Past 11, n.º 10 (6 de outubro de 2015): 1297–311. http://dx.doi.org/10.5194/cp-11-1297-2015.

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Abstract. Sea surface temperatures (SST) in the Guiana Basin over the last 140 ka were obtained by measuring the C37 alkenone unsaturation index Uk'37 in the sediment core MD03-2616 (7° N, 53° W). The resulting data set is unique in the western tropical Atlantic region for this period. The SSTs range from 25.1 to 28.9 °C, i.e. glacial–interglacial amplitude of 3.8 °C, which is in the range of change of other tropical areas. During the last two interglacial stages (marine isotope stages; MIS1 and MIS5e) and warm long interstadials (MIS5d-a), a rapid transmission of climate variability from Arctic–tropical latitudes is recorded. During these periods, the MD03-2616 SSTs show a conspicuous parallelism with temperature changes observed in Greenland and SST records of North Atlantic mid-latitude cores (Iberian Margin 38° N, Martrat et al., 2007). The last deglaciation in the Guiana Basin is particularly revealing. MIS2 stands out as the coldest period of the interval analysed. The events recorded in Guiana parallel northern latitude events such as the Bølling–Allerød warming and the Younger Dryas cooling which ensued. These oscillations were previously documented in the δ18O of the Sajama tropical ice core (Bolivia) and are present in Guiana, with rates of ca. 6 °C ka−1 and changes of over 2 °C. During the glacial interval, significant abrupt variability is observed, e.g. oscillations of 0.5–1.2 °C during MIS3, which is about 30 % of the maximum glacial–interglacial SST change. In the MD03-2616 record, it is possible to unambiguously identify either the Dansgaard–Oeschger oscillations described in northern latitudes or the SST drops associated with the Heinrich events characteristic of North Atlantic records. Although these events form the background of the climate variability observed, what truly shapes SSTs in the Guiana Basin is a long-term tropical response to precessional changes, which is modulated in the opposite way to Northern Hemisphere variability. This lack of synchrony is consistent with other tropical records in locations to the north or south of the Guiana Basin and evidences an Arctic–tropical decoupling when a substantial reduction in the Atlantic meridional overturning circulation (AMOC) takes place.

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Bron, Peter A., Sally M. Hoffer, Iris I. Van Swam, Willem M. De Vos e Michiel Kleerebezem. "Selection and Characterization of Conditionally Active Promoters in Lactobacillus plantarum, Using Alanine Racemase as a Promoter Probe". Applied and Environmental Microbiology 70, n.º 1 (janeiro de 2004): 310–17. http://dx.doi.org/10.1128/aem.70.1.310-317.2004.

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ABSTRACT This paper describes the use of the alr gene, encoding alanine racemase, as a promoter-screening tool for the identification of conditional promoters in Lactobacillus plantarum. Random fragments of the L. plantarum WCFS1 genome were cloned upstream of the promoterless alr gene of Lactococcus lactis in a low-copy-number plasmid vector. The resulting plasmid library was introduced into an L. plantarum Δalr strain (MD007), and 40,000 clones were selected. The genome coverage of the library was estimated to be 98%, based on nucleotide insert sequence and restriction analyses of the inserts of randomly selected clones. The library was screened for clones that were capable of complementing the d-alanine auxotroph phenotype of MD007 in media containing up to 10, 100, or 300 μg of the competitive Alr inhibitor d-cycloserine per ml. Western blot analysis with polyclonal antibodies raised against lactococcal Alr revealed that the Alr production level required for growth increased in the presence of increasing concentrations of d-cycloserine, adding a quantitative factor to the primarily qualitative nature of the alr complementation screen. Screening of the alr complementation library for clones that could grow only in the presence of 0.8 M NaCl resulted in the identification of eight clones that upon Western blot analysis showed significantly higher Alr production under high-salt conditions than under low-salt conditions. These results established the effectiveness of the alanine racemase complementation screening method for the identification of promoters on their conditional or constitutive activity.

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Makaroğlu, Özlem, Norbert R. Nowaczyk, Kadir K. Eriş e M. Namık Çağatay. "High-resolution palaeomagnetic record from Sea of Marmara sediments for the last 70 ka". Geophysical Journal International 222, n.º 3 (5 de junho de 2020): 2024–39. http://dx.doi.org/10.1093/gji/ggaa281.

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SUMMARY Magnetostratigraphic and geochemical analyses were performed on two sediment cores recovered from the Sea of Marmara to investigate geomagnetic field variations over the last 70 ka. A chronology for each of the two cores was developed from eight AMS 14C datings, tephrochronology, and tuning of Ca concentrations with stadials and interstadials observed in Greenland ice core oxygen isotope data. Based on the age models, cores MD01–2430 and MRS-CS19 reach back to 70 and 32 ka, respectively. High average sedimentation rates of 43 cm kyr–1 for core MD01–2430 and 68 cm kyr–1 for core MRS-CS19 allow high-resolution reconstruction of geomagnetic field variations for the Sea of Marmara. Mineral magnetic properties are sensitive to glacioeustatic sea level changes and palaeoclimate variations in this region, reflecting the variable palaeoenvironmental conditions of the Sea of Marmara during last 70 ka. Despite the impairment of the palaeomagnetic record in some stratigraphic intervals due to early diagenesis, relative palaeointensity variations in the Sea of Marmara sediments correlate well with similar records derived from other regions, such as the nearby Black Sea and the GLOPIS-75 stack. The directional record derived from the Sea of Marmara cores exhibits typical palaeosecular variation patterns, with directional anomalies at 41 and 18 ka, representing the Laschamps and postulated Hilina Pali excursions, respectively. Both directional anomalies are also associated with palaeointensity minima. A further palaeointensity minimum at 34.5 ka is likely related to the Mono Lake excursion, with no directional deviation documented in the Sea of Marmara palaeomagnetic record so far.

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Sharma, Ankitta, e Laxmi Khanna. "P-MD017. Spinal segmental myoclonus masquerading as a pshycogenic movement disorder". Clinical Neurophysiology 132, n.º 8 (agosto de 2021): e101. http://dx.doi.org/10.1016/j.clinph.2021.02.235.

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Pataer, Abujiang, Sunil Chada, Jack A. Roth, Kelly K. Hunt e Stephen G. Swisher. "Development of Ad-mda7/IL-24-resistant lung cancer cell lines". Cancer Biology & Therapy 7, n.º 1 (janeiro de 2008): 103–8. http://dx.doi.org/10.4161/cbt.7.1.5162.

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Sepulcre, S., L. Vidal, K. Tachikawa, F. Rostek e E. Bard. "Sea-surface salinity variations in the northern Caribbean Sea across the Mid-Pleistocene Transition". Climate of the Past 7, n.º 1 (11 de fevereiro de 2011): 75–90. http://dx.doi.org/10.5194/cp-7-75-2011.

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Abstract. By reconstructing past hydrologic variations in the Northern Caribbean Sea and their influence on the stability of the Atlantic Meridional Overturning Circulation (AMOC) during the last 940 ka, we seek to document climate changes in this tropical area in response to the Mid-Pleistocene Transition (MPT). Using core MD03-2628, we estimated past changes in sea surface salinity (SSS) using Δδ18O, the difference between the modern, and the past δ18O of seawater (obtained by combining alkenone thermometer data with the δ18O of the planktonic foraminifera Globigerinoides rube (white) and corrected for ice-sheet volume effects). Today, the lowest SSS values in the area studied are associated with the northernmost location of the Inter-Tropical Convergence Zone (ITCZ). The Δδ18O record obtained from core MD03-2628 exhibits glacial/interglacial cyclicity with higher values during all glacial periods spanning the last 940 ka, indicating increased SSS. A long-term trend was also observed in the Δδ18O values that exhibited a shift toward lower values for interglacial periods during the last 450 ka, as compared to interglacial stages older than 650 ka. A rise in SSS during glacial stages may be related to the southernmost location of the ITCZ, which is induced by a steeper cross-equator temperature gradient and associated with reduced northward cross-equatorial oceanic transport. Therefore, the results suggest a permanent link between the tropical salinity budget and the AMOC during the last 940 ka. Following the MPT, lower salinities during the last five interglacial stages indicated a northernmost ITCZ location that was forced by changes in the cross-equator temperature gradient and that was associated with the poleward position of Southern Oceanic Fronts that amplify the transport of heat and moisture to the North Atlantic. These processes may have contributed to the amplification of the climate cycles that followed the MPT.

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Emerson, Paul, Martin Kollmann, Chad MacArthur, Simon Bush e Danny Haddad. "SAFE strategy for blinding trachoma addresses sanitation, the other half of MDG7". Lancet 380, n.º 9836 (julho de 2012): 27–28. http://dx.doi.org/10.1016/s0140-6736(12)61122-2.

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Chen, Yifeng, Ryo Matsumoto, Charles K. Paull, William Ussler, Thomas Lorenson, Patrick Hart e William Winters. "Methane-derived authigenic carbonates from the northern Gulf of Mexico — MD02 Cruise". Journal of Geochemical Exploration 95, n.º 1-3 (outubro de 2007): 1–15. http://dx.doi.org/10.1016/j.gexplo.2007.05.011.

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Levenstein, Charles, Gregory F. DeLaurier, Safi Ahmed e Edith D. Balbach. "Labor and the Tobacco Institute's Labor Management Committee in New York State: The Rise and Fall of a Political Coalition". NEW SOLUTIONS: A Journal of Environmental and Occupational Health Policy 15, n.º 2 (agosto de 2005): 135–52. http://dx.doi.org/10.2190/9c0m-07md-egx1-md08.

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In 1984 the Tobacco Institute and the Bakery, Confectionary and Tobacco Workers Union formed a Labor Management Committee. From the mid-1980s to the mid-1990s, this LMC worked to elicit labor support in New York by framing issues in terms that made them salient to unions: tobacco excise taxes as regressive taxation, workplace smoking restrictions as an intrusion into collective bargaining. By the late 1990s, however, most of labor in New York had shifted to support for anti-tobacco policies. The reasons for this shift include the growing size and influence of public-sector unions, and their generally favorable stances on tobacco control issues; the policy-making autonomy of the unions; the growing body of scientific knowledge concerning the dangers of tobacco use; and the rise in public awareness of such dangers. Nevertheless, for two decades, the LMC contributed to mutual suspicion between labor and tobacco control advocates that prevented collaboration between them.

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Roelofs, Cora. "Trade Unions and Cleaner Production: Perspectives and Proposals for Action". NEW SOLUTIONS: A Journal of Environmental and Occupational Health Policy 9, n.º 3 (novembro de 1999): 277–95. http://dx.doi.org/10.2190/drwr-lv3k-k2mg-md0e.

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Zhang, Taifeng, Jiajun Liu, Shi Liu, Zhuo Ding, Feishi Luan e Peng Gao. "Bulked-segregant Analysis Identified a Putative Region Related to Short Internode Length in Melon". HortScience 54, n.º 8 (agosto de 2019): 1293–98. http://dx.doi.org/10.21273/hortsci14052-19.

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Short internode length (SIL) is one of the most commercially and important traits in melon varieties (Cucumis melo L.). SIL can result in a compact vining type that promotes concentrated fruit in high-density crops, leading to greater use of light resources for photosynthesis and greater yield per unit area. In our study, two parental melon lines ‘M1-32’ (P1, standard vine) and ‘X090’ (P2, short internodes), and their F1, F2, BC1P1, and BC1P2 progenies were evaluated after being grown in plastic greenhouse conditions in 2017 and 2018. Main stem length (MSL) and internode length (IL) of six melon generations indicated that a single recessive gene (MD7) controlled dwarfism in the ‘X090’ melon line. Whole-genome analysis revealed a genomic region harboring the candidate dwarfism gene on chromosome 7. Six polymorphic cleaved amplified polymorphic sequence (CAPS) markers from chromosome 7 were used to construct a genetic linkage that spanned 30.28 cM. The melon dwarfing locus MD7 responsible for SIL was positioned between markers M7-4 and M7-5, with 3.16 cM of flanking distance. The CAPS markers M7-4 and M7-5 developed have the potential to accelerate the development of dwarf melon varieties, especially in situations when dwarf genotypes are an important breeding goal using marker-assisted selection.

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Chambers, J., PJ Neumann e MJ Buxton. "MD7 DOES MEDICARE HAVE AN IMPLICIT COST-EFFECTIVENESS THRESHOLD?" Value in Health 12, n.º 3 (maio de 2009): A15—A16. http://dx.doi.org/10.1016/s1098-3015(10)73136-3.

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Sicre, M. A., G. Siani, D. Genty, N. Kallel e L. Essallami. "Seemingly divergent sea surface temperature proxy records in the central Mediterranean during the last deglaciation". Climate of the Past 9, n.º 3 (28 de junho de 2013): 1375–83. http://dx.doi.org/10.5194/cp-9-1375-2013.

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Abstract. Sea surface temperatures (SSTs) were reconstructed over the last 25 000 yr using alkenone paleothermometry and planktonic foraminifera assemblages from two cores of the central Mediterranean Sea: the MD04-2797 core (Siculo–Tunisian channel) and the MD90-917 core (South Adriatic Sea). Comparison of the centennial scale structure of the two temperature signals during the last deglaciation period reveals significant differences in timing and amplitude. We suggest that seasonal changes likely account for seemingly proxy record divergences during abrupt transitions from glacial to interglacial climates and for the apparent short duration of the Younger Dryas (YD) depicted by the alkenone time series, a feature that has already been stressed in earlier studies on the Mediterranean deglaciation.

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Sicre, M. A., G. Siani, D. Genty, N. Kallel e L. Essallami. "Seemingly divergent sea surface temperature proxy records in the central Mediterranean during the last deglacial". Climate of the Past Discussions 9, n.º 1 (4 de fevereiro de 2013): 683–701. http://dx.doi.org/10.5194/cpd-9-683-2013.

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Abstract. Sea surface temperatures (SSTs) were reconstructed over the last 25 000 yr using alkenone paleothermometry and planktonic foraminifera assemblages from two cores of the central Mediterranean Sea: the MD04-2797 core (Siculo–Tunisian channel) and the MD90-917 core (South Adriatic Sea). Comparison of the centennial scale structure of the two temperature signals during the last deglacial period reveals significant differences in timing and amplitude. We suggest seasonal changes likely account for seeming proxy record divergences during abrupt transitions from glacial to interglacial climates and for the apparent short duration of the Younger Dryas (YD) depicted by the alkenone time-series, a feature that has already been stressed in earlier studies on the Mediterranean deglaciation.

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Seong, Rak-Kyun, Young-Ki Choi e Ok Sarah Shin. "MDA7/IL-24 is an anti-viral factor that inhibits influenza virus replication". Journal of Microbiology 54, n.º 10 (30 de setembro de 2016): 695–700. http://dx.doi.org/10.1007/s12275-016-6383-2.

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Rabbani, A., W. Yin, JX Zhang, SX Sun e GC Alexander. "MD7 DIFFERENTIALTAKE-UP OFTHE MEDICARE PART D PRESCRIPTION DRUG BENEFIT". Value in Health 11, n.º 3 (maio de 2008): A12—A13. http://dx.doi.org/10.1016/s1098-3015(10)70054-1.

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Chou, Yu-Min, Teh-Quei Lee, Sheng-Rong Song e Kuang-Jung Chen. "Magnetostratigraphy of marine sediment core MD01-2414 from Okhotsk Sea and its paleoenvironmental implications". Marine Geology 284, n.º 1-4 (junho de 2011): 149–57. http://dx.doi.org/10.1016/j.margeo.2011.03.015.

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Daniau, Anne-Laure, Maria Fernanda Sánchez Goñi e Josette Duprat. "Last glacial fire regime variability in western France inferred from microcharcoal preserved in core MD04-2845, Bay of Biscay". Quaternary Research 71, n.º 3 (maio de 2009): 385–96. http://dx.doi.org/10.1016/j.yqres.2009.01.007.

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AbstractHigh resolution multiproxy analysis (microcharcoal, pollen, organic carbon, Neogloboquadrina pachyderma (s), ice rafted debris) of the deep-sea record MD04-2845 (Bay of Biscay) provides new insights for understanding mechanisms of fire regime variability of the last glacial period in western France. Fire regime of western France closely follows Dansgaard–Oeschger climatic variability and presents the same pattern than that of southwestern Iberia, namely low fire regime associated with open vegetation during stadials including Heinrich events, and high fire regime associated with open forest during interstadials. This supports a regional climatic control on fire regime for western Europe through fuel availability for the last glacial period. Additionally, each of Heinrich events 6, 5 and 4 is characterised by three episodes of fire regime, with a high regime bracketed by lower fire regime episodes, related to vegetational succession and complex environmental condition changes.

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Desprat, S., N. Combourieu-Nebout, L. Essallami, M. A. Sicre, I. Dormoy, O. Peyron, G. Siani, V. Bout Roumazeilles e J. L. Turon. "Deglacial and Holocene vegetation and climatic changes in the southern Central Mediterranean from a direct land–sea correlation". Climate of the Past 9, n.º 2 (20 de março de 2013): 767–87. http://dx.doi.org/10.5194/cp-9-767-2013.

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Abstract. Despite a large number of studies, the long-term and millennial to centennial-scale climatic variability in the Mediterranean region during the last deglaciation and the Holocene is still debated, including in the southern Central Mediterranean. In this paper, we present a new marine pollen sequence (core MD04-2797CQ) from the Siculo-Tunisian Strait documenting the regional vegetation and climatic changes in the southern Central Mediterranean during the last deglaciation and the Holocene. The MD04-2797CQ marine pollen sequence shows that semi-desert plants dominated the vegetal cover in the southern Central Mediterranean between 18.2 and 12.3 ka cal BP, indicating prevailing dry conditions during the deglaciation, even during the Greenland Interstadial (GI)-1. Across the transition Greenland Stadial (GS)-1 – Holocene, Asteraceae-Poaceae steppe became dominant till 10.1 ka cal BP. This record underlines with no chronological ambiguity that even though temperatures increased, deficiency in moisture availability persisted into the early Holocene. Temperate trees and shrubs with heath underbrush or maquis expanded between 10.1 and 6.6 ka, corresponding to Sapropel 1 (S1) interval, while Mediterranean plants only developed from 6.6 ka onwards. These changes in vegetal cover show that the regional climate in southern Central Mediterranean was wetter during S1 and became drier during the mid- to late Holocene. Wetter conditions during S1 were likely due to increased winter precipitation while summers remained dry. We suggest, in agreement with published modeling experiments, that the early Holocene increased melting of the Laurentide Ice Sheet in conjunction with weak winter insolation played a major role in the development of winter precipitation maxima in the Mediterranean region in controlling the strength and position of the North Atlantic storm track. Finally, our data provide evidence for centennial-scale vegetation and climatic changes in the southern Central Mediterranean. During the wet early Holocene, alkenone-derived cooling episodes are synchronous with herbaceous composition changes that indicate muted changes in precipitation. In contrast, enhanced aridity episodes, as detected by strong reduction in trees and shrubs, are recorded during the mid- to late Holocene. We show that the impact of the Holocene cooling events on the Mediterranean hydroclimate depend on baseline climate states, i.e. insolation and ice sheet extent, shaping the response of the mid-latitude atmospheric circulation.

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Mulyana, Rita, e Syahrul. "P-MD007. Hemichorea-hemiballismus with non-ketotic hyperglycemia: A movement disorder related to diabetes mellitus". Clinical Neurophysiology 132, n.º 8 (agosto de 2021): e98. http://dx.doi.org/10.1016/j.clinph.2021.02.227.

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Aoki, Kaori, Tomohisa Irino e Tadamichi Oba. "Late Pleistocene tephrostratigraphy of the sediment core MD01-2421 collected off the Kashima coast, Japan". Quaternary Research (Daiyonki-Kenkyu) 47, n.º 6 (2008): 391–407. http://dx.doi.org/10.4116/jaqua.47.391.

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Yamamoto, Masanobu, Yutaka Ichikawa, Yaeko Igarashi e Tadamichi Oba. "Late Quaternary variation of lignin composition in core MD01-2421 off central Japan, NW Pacific". Palaeogeography, Palaeoclimatology, Palaeoecology 229, n.º 3 (dezembro de 2005): 179–86. http://dx.doi.org/10.1016/j.palaeo.2005.06.021.

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Li, Haiyan, Shihong Zhang, Nianqiao Fang e Hongqiang Wang. "Magnetic records of Core MD77-181 in the Bay of Bengal and their paleoenvironmental implications". Chinese Science Bulletin 51, n.º 15 (agosto de 2006): 1884–93. http://dx.doi.org/10.1007/s11434-006-2057-5.

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Cobianchi, M., V. Luciani, C. Lupi, N. Mancin, F. Lirer, N. Pelosi, I. Trattenero, M. Bordiga, I. R. Hall e M. Sprovieri. "Pleistocene biogeochemical record in the south-west Pacific Ocean (images site MD97-2114, Chatham Rise)". Journal of Quaternary Science 27, n.º 5 (10 de maio de 2012): 519–30. http://dx.doi.org/10.1002/jqs.2542.

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Bard, Edouard, Guillemette Ménot, Frauke Rostek, Laetitia Licari, Philipp Böning, R. Lawrence Edwards, Hai Cheng, Yongjin Wang e Timothy J. Heaton. "Radiocarbon Calibration/Comparison Records Based on Marine Sediments from the Pakistan and Iberian Margins". Radiocarbon 55, n.º 4 (2013): 1999–2019. http://dx.doi.org/10.2458/azu_js_rc.55.17114.

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We present a new record of radiocarbon ages measured by accelerator mass spectrometry (AMS) on a deep-sea core collected off the Pakistan Margin. The 14C ages measured on the planktonic foraminifera Globigerinoides ruber from core MD04-2876 define a high and stable sedimentation rate on the order of 50 cm/kyr over the last 50 kyr. The site is distant from the main upwelling zone of the western Arabian Sea where 14C reservoir age is large and may be variable. Many independent proxies based on elemental analyses, mineralogy, biomarkers, isotopic proxies, and foraminiferal abundances show abrupt changes correlative with Dansgaard-Oeschger and Heinrich events. It is now common knowledge that these climatic events also affected the Arabian Sea during the last glacial period through changes in the Indian monsoon and in ventilation at intermediate depths. The stratigraphic agreement between all proxies, from fine- to coarse-size fractions, indicates that the foraminiferal 14C ages are representative of the different sediment fractions.To build a calendar age scale for core MD04-2876, we matched its climate record to the oxygen isotopic (δ18O) profile of Hulu Cave stalagmites that have been accurately dated by U-Th (Wang et al. 2001; Southon et al. 2012; Edwards et al., submitted). Both archives exhibit very similar signatures, even for century-long events linked to monsoonal variations. For comparison, we have also updated our previous work on core MD95-2042 from the Iberian Margin (Bard et al. 2004a,b,c), whose climate record has likewise been tuned to the high-resolution δ18O Hulu Cave profile. Sophisticated and novel statistical techniques were used to interpolate ages and calculate uncertainties between chronological tie-points (Heaton et al. 2013, this issue). The data from the Pakistan and Iberian margins compare well even if they come from distant sites characterized by different oceanic conditions. Collectively, the data also compare well with the IntCal09 curve, except for specific intervals around 16 cal kyr BP and from 28 to 31 cal kyr BP. During these intervals, the data indicate that 14C is somewhat older than indicated by the IntCal09 curve. Agreement between the data from both oceanic sites suggests that the discrepancy is not due to local changes of sea-surface 14C reservoir ages, but rather that the IntCal09 curve needed to be updated in these intervals as has been done in the framework of IntCal13 (Reimer et al. 2013a, this issue).

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Desprat, S., N. Combourieu-Nebout, L. Essallami, M. A. Sicre, I. Dormoy, O. Peyron, G. Siani, V. Bout Roumazeilles e J. L. Turon. "Deglacial and Holocene vegetation and climatic changes at the southernmost tip of the Central Mediterranean from a direct land-sea correlation". Climate of the Past Discussions 8, n.º 6 (21 de novembro de 2012): 5687–741. http://dx.doi.org/10.5194/cpd-8-5687-2012.

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Abstract. Despite a large number of studies, the long-term and millennial to centennial-scale climatic variability in the Mediterranean region during the last deglaciation and the Holocene is still debated, in particular in the Southern Central Mediterranean. In this paper, we present a new marine pollen sequence (MD04-2797CQ) from the Siculo-Tunisian Strait documenting the regional vegetation and climatic changes in the Southern Central Mediterranean during the last deglaciation and the Holocene. The MD04-2797CQ marine pollen sequence shows that semi-desert plants dominated the vegetal cover in the Southern Central Mediterranean between 18 and 12.3 kyr BP indicating prevailing dry conditions during the deglaciation, even during the Greenland Interstadial (GI)-1. Such arid conditions likely restricted the expansion of the trees and shrubs despite the GI-1 climatic amelioration. Across the transition Greenland Stadial (GS)-1 – Holocene, Asteraceae-Poaceae steppe became dominant till 10.1 kyr. This record underlines with no chronological ambiguity that even though temperatures increased, deficiency in moisture availability persisted into the Early Holocene.Temperate trees and shrubs with heaths as oak forest understorey or heath maquis expanded between 10.1 and 6.6 kyr, while Mediterranean plants only developed from 6.6 kyr onwards. These changes in vegetal cover show that the regional climate in Southern Central Mediterranean was wetter during Sapropel 1 (S1) and became drier during the Mid- to Late Holocene. Wetter conditions during S1 were likely due to increased winter precipitation while summers remained dry. We suggest, in agreement with published modelling experiments, that the increased melting of the Laurentide Ice Sheet between 10 to 6.8 kyr in conjunction with weak winter insolation played a major role in the development of winter precipitation maxima in the Mediterranean region in controlling the strength and position of the North Atlantic storm track. Finally, our data provide evidences of centennial-scale vegetation and climatic changes in the Southern Central Mediterranean. During the wet Early Holocene, alkenones-derived cooling episodes are synchronous to herbaceous composition changes that indicate muted changes in precipitation. In contrast, enhanced aridity episodes, as detected by strong reduction in trees and shrubs, are recorded during the Mid- to Late Holocene. We show that the impact of the Holocene cooling events depend on the baseline climate states insolation and ice sheet volume, shaping the response of the mid-latitude atmospheric circulation.

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CHEN, Shuangxi, Tiegang LI, Qingyun NAN, Zheng TANG e Xiaohua QIU. "RECONSTRUCTION OF SEA SURFACE TEMPERATURE USING PLANKTONIC FORAMINIFERA FROM CORE MD06-3054 IN THE NORTHWESTERN PACIFIC". Marine Geology & Quaternary Geology 31, n.º 3 (26 de agosto de 2011): 61–68. http://dx.doi.org/10.3724/sp.j.1140.2011.03061.

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Naguib, M., P. Diaz, J. J. Xu, F. Astruc-Diaz, S. Craig, P. Vivas-Mejia e D. L. Brown. "MDA7: a novel selective agonist for CB2 receptors that prevents allodynia in rat neuropathic pain models". British Journal of Pharmacology 155, n.º 7 (dezembro de 2008): 1104–16. http://dx.doi.org/10.1038/bjp.2008.340.

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Cao, Hongdan, Tingxiu Xiang, Chaohong Zhang, Hong Yang, Lingqun Jiang, Shanli Liu e Xiaolan Huang. "MDA7 combined with targeted attenuated Salmonella vector SL7207/pBud-VP3 inhibited growth of gastric cancer cells". Biomedicine & Pharmacotherapy 83 (outubro de 2016): 809–15. http://dx.doi.org/10.1016/j.biopha.2016.07.042.

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Li, Tao, e Peng Wang. "Richness and diversity of bacteria in the Nansha carbonate platform (Core MD05-2896), South China Sea". World Journal of Microbiology and Biotechnology 29, n.º 10 (23 de maio de 2013): 1895–905. http://dx.doi.org/10.1007/s11274-013-1354-9.

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Li, Tao, e Peng Wang. "Bacterial diversity in sediments of core MD05-2902 from the Xisha Trough, the South China Sea". Acta Oceanologica Sinica 33, n.º 10 (outubro de 2014): 85–93. http://dx.doi.org/10.1007/s13131-014-0543-1.

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Liu, Tingting, e Suvi Gezari. "A Periodically Varying Luminous Quasar at z = 2 from the Pan-STARRS1 Medium Deep Survey: A Candidate Supermassive Black Hole Binary in the Gravitational Wave-Driven Regime". Proceedings of the International Astronomical Union 11, A29B (agosto de 2015): 354–56. http://dx.doi.org/10.1017/s1743921316005512.

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AbstractSupermassive black hole binaries (SMBHBs) should be an inevitable consequence of the hierarchical growth of massive galaxies through mergers and the strongest sirens of gravitational waves (GWs) in the cosmos. Yet, their direct detection has remained elusive due to the compact (sub-parsec) orbital separations of gravitationally bound SMBHBs. Here we exploit a theoretically predicted signature of SMBHBs in the time domain. We have begun a systematic search for SMBHB candidates in the Pan-STARRS1 Medium Deep Survey (MDS) and reported our first significant detection of such a candidate from our pilot study of MD09 in Liu et al. (2015). Our candidate PSO J334.2028+01.4075 has a detected period of 542 days, varying persistently over the available baseline. From its archival spectrum, we estimated the black hole mass of the z = 2.06 quasar to be ∼1010 M⊙. The inferred ∼7 Rs binary separation therefore puts this candidate in the regime of GW-dominated orbital decay, opening up the exciting possibility of finding GW sources detectable by pulsar timing arrays (PTAs) in a wide-field optical synoptic survey.

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Li, Qianyu, Fan Zheng, Muhong Chen, Rong Xiang, Peijun Qiao, Lei Shao e Xinrong Cheng. "Glacial Paleoceanography off the Mouth of the Mekong River, Southern South China Sea, During the last 500 ka". Quaternary Research 73, n.º 3 (maio de 2010): 563–72. http://dx.doi.org/10.1016/j.yqres.2010.03.003.

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We have analyzed core MD01-2392, ∽360 km east of the Mekong River mouth in the South China Sea (SCS). Over the past 500 ka, planktonic foraminiferal oxygen-isotopic values are consistently lighter than northern SCS and open-ocean records by up to 0.5‰, indicating the influence of run-off from the Mekong River during both glacial and interglacial periods. Carbonate content is higher during interglacials; sedimentation rates were higher during glacials. Increased sedimentation rates since 30 ka imply increased run-off during the last glacial maximum and Holocene Period. Contrary to general experience, in which it is classed as a warm species for temperature estimates, the thermocline-dwelling species Pulleniatina obliquiloculata increased its numbers during glacial periods. This implies an estuarine circulation and even brackish-water caps during glacial periods, reinforcing the sense of strong run-off. In an overall decline of warm water, the thermocline shoaled stepwise, with rapid rises across the glacial terminations. We infer that the southern SCS was opened to an influx of Indian Ocean waters through southern passages at those times of rising sea levels.

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Kang, Se-Goo, e Young-Jin Suh. "In VitroEnhancement of Radiosensitivity by the Combination of Celecoxib and Ad-mda7 in Human Breast Cancer Cells". Journal of Breast Cancer 13, n.º 3 (2010): 275. http://dx.doi.org/10.4048/jbc.2010.13.3.275.

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Santamaría Alzate, Pablo. "Arte y cultura para el cambio social: el caso del Encuentro Internacional de Medellín 2007 / MDE07, Colombia." Políticas Culturais em Revista 13, n.º 2 (24 de setembro de 2020): 136. http://dx.doi.org/10.9771/pcr.v13i2.36648.

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El presente artículo analiza el aporte del arte y la cultura al proceso de transformación social que vivió Medellín, Colombia, durante el primer decenio del presente siglo. Esta ciudad tuvo entre 1984 y 1996 uno de los periodos más violentos de su historia reciente; durante esta época colectivos culturales comunitarios emprendieron una labor de resistencia a la violencia y a la estigmatización. La política pública cultural de la época recoge estas experiencias y coordina esfuerzos institucionales para configurar un nuevo tipo de subjetividad ciudadana, estimulando la convivencia y la hospitalidad. Bajo estos principios se desarrolla en 2007 el “Encuentro Internacional Medellín 07, prácticas artísticas contemporáneas, espacios de hospitalidad” en el cual se articulan varios conceptos de la planificación cultural de Medellín de finales del siglo XX y principios del nuevo siglo.

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Cosma, T. N., I. L. Hendy e A. S. Chang. "Chronological constraints on Cordilleran Ice Sheet glaciomarine sedimentation from core MD02-2496 off Vancouver Island (western Canada)". Quaternary Science Reviews 27, n.º 9-10 (maio de 2008): 941–55. http://dx.doi.org/10.1016/j.quascirev.2008.01.013.

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Masciocchi, Daniela, Stefania Villa, Fiorella Meneghetti, Alessandro Pedretti, Daniela Barlocco, Laura Legnani, Lucio Toma et al. "Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors". MedChemComm 3, n.º 5 (2012): 592. http://dx.doi.org/10.1039/c2md20018j.

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Valsecchi, V., M. F. Sanchez Goñi e L. Londeix. "Vegetation dynamics in the Northeastern Mediterranean region during the past 23 000 yr: insights from a new pollen record from the Sea of Marmara". Climate of the Past 8, n.º 6 (6 de dezembro de 2012): 1941–56. http://dx.doi.org/10.5194/cp-8-1941-2012.

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Abstract. High-resolution pollen analysis of core MD01-2430 from the Sea of Marmara (40°47.81' N, 27°43.51' E) allows us to reconstruct the vegetation response to climatic changes during the past 23 cal ka in the Northeastern Mediterranean. Variation in mesic/temperate forest cover indicates major climatic shifts connected to Heinrich Stadial 1, Bölling-Allerød, Younger Dryas and to the onset of the Holocene. Pollen–anthropogenic indicator approach was used to recognize human-induced landscape changes in the Sea of Marmara. The pollen-inferred onset of the Holocene occurs at ca. 11.5 cal ka, indicating that the Northeastern Mediterranean region represents a transitional zone where higher moisture availability supported an earlier forest expansion than the borderlands of the Aegean Sea and Black Sea. Two major forest retreats occurred during the Holocene at ca. 5.5 and 2.1 cal ka. The Holocene forest setbacks are in phase with previously published alkenone-inferred sea-surface temperature decreases in the Sea of Marmara reconstructed from the same core. Our new pollen record testifies the sensitivity of Mediterranean forests to changes in moisture availability, which is driven by changes in high-latitude atmospheric processes (North Atlantic Oscillations and/or Siberian High).

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Enkin, Randolph J., Audrey Dallimore, Judith Baker, John R. Southon e Tara Ivanochko. "A new high-resolution radiocarbon Bayesian age model of the Holocene and Late Pleistocene from core MD02-2494 and others, Effingham Inlet, British Columbia, Canada; with an application to the paleoseismic event chronology of the Cascadia Subduction Zone". Canadian Journal of Earth Sciences 50, n.º 7 (julho de 2013): 746–60. http://dx.doi.org/10.1139/cjes-2012-0150.

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Annually laminated sediments from the anoxic inner basin of Effingham Inlet, Pacific coast of Vancouver Island, British Columbia, Canada, yield a high-resolution 42 m paleoenvironmental record, from the present to about 14 ka 14C BP (17 ka cal BP). A new age model, based on 68 radiocarbon dates from twigs and small plant material, from the 40 m core MD02-2494 and 2 m freeze cores from the surface, is anchored by the Mazama Ash and varve counting. A Poisson-process sedimentation model is used, applying a new method to determine the Poisson k value, giving a realistic age model compatible with the multi-proxy core data. Twenty-one “seismites”, which are lithofacies in the Effingham cores that may be representative of seismically triggered mass-wasting events, are identified and dated precisely, then compared with the chronology of the deep-sea turbidite record farther south in the Cascadia Subduction Zone (CSZ), to determine if regional sediment disturbances can be identified. With 16 proposed correlations, Effingham seismite ages are 169 ± 206 years older than turbidite ages estimated largely by radiocarbon analysis of foraminifera in hemipelagic deposits.

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