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Bibliografias temáticas / Manipulation (Therapeutics)

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Literatura científica selecionada sobre o tema "Manipulation (Therapeutics)"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 30 de julho de 2024

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Artigos de revistas sobre o assunto "Manipulation (Therapeutics)"

1

Hao, Mengling, Jiabao Tang, Shengxiang Ge, Tingdong Li e Ningshao Xia. "Bacterial-Artificial-Chromosome-Based Genome Editing Methods and the Applications in Herpesvirus Research". Microorganisms 11, n.º 3 (26 de fevereiro de 2023): 589. http://dx.doi.org/10.3390/microorganisms11030589.

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Herpesviruses are major pathogens that infect humans and animals. Manipulating the large genome is critical for exploring the function of specific genes and studying the pathogenesis of herpesviruses and developing novel anti-viral vaccines and therapeutics. Bacterial artificial chromosome (BAC) technology significantly advanced the capacity of herpesviruses researchers to manipulate the virus genomes. In the past years, advancements in BAC-based genome manipulating and screening strategies of recombinant BACs have been achieved, which has promoted the study of the herpes virus. This review summarizes the advances in BAC-based gene editing technology and selection strategies. The merits and drawbacks of BAC-based herpesvirus genome editing methods and the application of BAC-based genome manipulation in viral research are also discussed. This review provides references relevant for researchers in selecting gene editing methods in herpes virus research. Despite the achievements in the genome manipulation of the herpes viruses, the efficiency of BAC-based genome manipulation is still not satisfactory. This review also highlights the need for developing more efficient genome-manipulating methods for herpes viruses.

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Almeida-Porada, Graça D. "Stem cell gene manipulation and delivery as systemic therapeutics". Advanced Drug Delivery Reviews 62, n.º 12 (setembro de 2010): 1139–40. http://dx.doi.org/10.1016/j.addr.2010.10.005.

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Juliano, Rudolph L. "Chemical Manipulation of the Endosome Trafficking Machinery: Implications for Oligonucleotide Delivery". Biomedicines 9, n.º 5 (5 de maio de 2021): 512. http://dx.doi.org/10.3390/biomedicines9050512.

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Antisense oligonucleotides (ASOs), siRNA and splice switching oligonucleotides (SSOs) all have immense potential as therapeutic agents, potential that is now being validated as oligonucleotides enter the clinic. However, progress in oligonucleotide-based therapeutics has been limited by the difficulty in delivering these complex molecules to their sites of action in the cytosol or nucleus of cells within specific tissues. There are two aspects to the delivery problem. The first is that most types of oligonucleotides have poor uptake into non-hepatic tissues. The second is that much of the oligonucleotide that is taken up by cells is entrapped in endosomes where it is pharmacologically inert. It has become increasingly recognized that endosomal trapping is a key constraint on oligonucleotide therapeutics. Thus, many approaches have been devised to address this problem, primarily ones based on various nanoparticle technologies. However, recently an alternative approach has emerged that employs small molecules to manipulate intracellular trafficking processes so as to enhance oligonucleotide actions. This review presents the current status of this chemical biology approach to oligonucleotide delivery and seeks to point out possible paths for future development.

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Wang, Ziyi, Pengchao Sun, Jingjing Su, Nan Zhang, Hongzhou Gu e Yongxing Zhao. "DNA nanotechnology-facilitated ligand manipulation for targeted therapeutics and diagnostics". Journal of Controlled Release 340 (dezembro de 2021): 292–307. http://dx.doi.org/10.1016/j.jconrel.2021.11.004.

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Wu, Yingjie, Yining Chen, Xiaochun Yu, Minxing Zhang e Zhaoyu Li. "Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans". International Journal of Molecular Sciences 25, n.º 1 (28 de dezembro de 2023): 443. http://dx.doi.org/10.3390/ijms25010443.

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The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Alzheimer’s disease (AD), Parkinson’s disease (PD) and Machado–Joseph disease (MJD), demands urgent disease-modifying therapeutics. Owing to the evolutionarily conserved molecular signalling pathways with mammalian species and facile genetic manipulation, the nematode Caenorhabditis elegans (C. elegans) emerges as a powerful and manipulative model system for mechanistic insights into neurodegenerative diseases. Herein, we review several representative C. elegans models established for five common neurodegenerative diseases, which closely simulate disease phenotypes specifically in the gain-of-function aspect. We exemplify applications of high-throughput genetic and drug screenings to illustrate the potential of C. elegans to probe novel therapeutic targets. This review highlights the utility of C. elegans as a comprehensive and versatile platform for the dissection of neurodegenerative diseases at the molecular level.

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Shanahan, Fergus. "Physiological Basis for Novel Drug Therapies Used to Treat the Inflammatory Bowel Diseases I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease". American Journal of Physiology-Gastrointestinal and Liver Physiology 288, n.º 3 (março de 2005): G417—G421. http://dx.doi.org/10.1152/ajpgi.00421.2004.

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Mechanisms underlying the conditioning influence of the intestinal flora on mucosal homeostasis, including development and function of immune responses, are attracting increasing scientific scrutiny. The intestinal flora is a positive asset to host defense, but some of its components may, in genetically susceptible hosts, become a risk factor for development of inflammatory bowel disease (IBD). It follows that strategies to enhance assets or offset microbial liabilities represent a therapeutic option; therein lies the rationale for manipulation of the flora in IBD. In addition, the diversity of regulatory signalling among the flora and host epithelum, lymphoid tissue, and neuromuscular apparatus is an untapped reservoir from which novel therapeutics may be mined. Moreover, the capacity to engineer food-grade or commensal bacteria to deliver therapeutic molecules to the intestinal mucosa promises to extend the scope of microbial manipulation for the benefit of mankind.

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Papageorgiou, Maria, e Emmanuel Biver. "Interactions of the microbiome with pharmacological and non-pharmacological approaches for the management of ageing-related musculoskeletal diseases". Therapeutic Advances in Musculoskeletal Disease 13 (janeiro de 2021): 1759720X2110090. http://dx.doi.org/10.1177/1759720x211009018.

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Despite major progress in the understanding of the pathophysiology and therapeutic options for common ageing-related musculoskeletal conditions (i.e. osteoporosis and associated fractures, sarcopenia and osteoarthritis), there is still a considerable proportion of patients who respond sub optimally to available treatments or experience adverse effects. Emerging microbiome research suggests that perturbations in microbial composition, functional and metabolic capacity (i.e. dysbiosis) are associated with intestinal and extra-intestinal disorders including musculoskeletal diseases. Besides its contributions to disease pathogenesis, the role of the microbiome is further extended to shaping individuals’ responses to disease therapeutics (i.e. pharmacomicrobiomics). In this review, we focus on the reciprocal interactions between the microbiome and therapeutics for osteoporosis, sarcopenia and osteoarthritis. Specifically, we identify the effects of therapeutics on microbiome’s configurations, functions and metabolic output, intestinal integrity and immune function, but also the effects of the microbiome on the metabolism of these therapeutics, which in turn, may influence their bioavailability, efficacy and side-effect profile contributing to variable treatment responses in clinical practice. We further discuss emerging strategies for microbiota manipulation as preventive or therapeutic (alone or complementary to available treatments) approaches for improving outcomes of musculoskeletal health and disease.

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Brown, Thomas J., e Victoria James. "The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: A Systematic Review". Cancers 13, n.º 10 (18 de maio de 2021): 2435. http://dx.doi.org/10.3390/cancers13102435.

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Cancer stem cells (CSCs) have increasingly been shown to be a crucial element of heterogenous tumors. Although a relatively small component of the population, they increase the resistance to treatment and the likelihood of recurrence. In recent years, it has been shown, across multiple cancer types (e.g., colorectal, breast and prostate), that reciprocal communication between cancer and the microenvironment exists, which is, in part, facilitated by extracellular vesicles (EVs). However, the mechanisms of this method of communication and its influence on CSC populations is less well-understood. Therefore, the aim of this systematic review is to determine the evidence that supports the role of EVs in the manipulation of the tumor microenvironment to promote the survival of CSCs. Embase and PubMed were used to identify all studies on the topic, which were screened using PRISMA guidelines, resulting in the inclusion of 16 studies. These 16 studies reported on the EV content, pathways altered by EVs and therapeutic targeting of CSC through EV-mediated changes to the microenvironment. In conclusion, these studies demonstrated the role of EV-facilitated communication in maintaining CSCs via manipulation of the tumor microenvironment, demonstrating the potential of creating therapeutics to target CSCs. However, further works are needed to fully understand the targetable mechanisms upon which future therapeutics can be based.

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Bondhopadhyay, Banashree, Sandeep Sisodiya, Faisal Abdulrahman Alzahrani, Muhammed A. Bakhrebah, Atul Chikara, Vishakha Kasherwal, Asiya Khan et al. "Exosomes: A Forthcoming Era of Breast Cancer Therapeutics". Cancers 13, n.º 18 (17 de setembro de 2021): 4672. http://dx.doi.org/10.3390/cancers13184672.

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Despite the recent advancements in therapeutics and personalized medicine, breast cancer remains one of the most lethal cancers among women. The prognostic and diagnostic aids mainly include assessment of tumor tissues with conventional methods towards better therapeutic strategies. However, current era of gene-based research may influence the treatment outcome particularly as an adjunct to diagnostics by exploring the role of non-invasive liquid biopsies or circulating markers. The characterization of tumor milieu for physiological fluids has been central to identifying the role of exosomes or small extracellular vesicles (sEVs). These exosomes provide necessary communication between tumor cells in the tumor microenvironment (TME). The manipulation of exosomes in TME may provide promising diagnostic/therapeutic strategies, particularly in triple-negative breast cancer patients. This review has described and highlighted the role of exosomes in breast carcinogenesis and how they could be used or targeted by recent immunotherapeutics to achieve promising intervention strategies.

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Mahajan, Kalpesh D., Gang Ruan, Greg Vieira, Thomas Porter, Jeffrey J. Chalmers, R. Sooryakumar e Jessica O. Winter. "Biomolecular detection, tracking, and manipulation using a magnetic nanoparticle-quantum dot platform". Journal of Materials Chemistry B 8, n.º 16 (2020): 3534–41. http://dx.doi.org/10.1039/c9tb02481f.

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Fluorescent and magnetic materials play a significant role in biosensor technology, enabling sensitive quantification and separations with applications in diagnostics, purification, quality control, and therapeutics.

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Teses / dissertações sobre o assunto "Manipulation (Therapeutics)"

1

Simmonds, Marian. "The effect of neck manipulation on excitability of the motor cortex thesis submission to Auckland University of Technology in partial fulfilment of the degree of Master of Health Science, 2004". Full thesis. Abstract, 2004.

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2

Duffy, Margaret R. "Investigation and manipulation of adenovirus interactions with host proteins". Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3582/.

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Adenoviruses are the most commonly used vectors for clinical gene therapy applications, accounting for 24% of all clinical trials to date, the majority of which are based on Ad serotype 5 (Ad5). However, the high prevalence of neutralising antibodies and a range of “off target” interactions result in liver sequestration, hepatic transduction and decreased circulation times. Such interactions include Kupffer cell uptake and binding to blood components such as erythrocytes, platelets, complement and coagulation factors. Recent studies have shown that hepatocyte transduction by Ad5 is mediated by a high-affinity interaction between coagulation factor X (FX) and the Ad5 major capsid protein hexon, with FX bridging the virus to heparan sulphate proteoglycans (HSPGs) on the cell surface. This thesis has focused on gaining a greater understanding of the Ad5:FX pathway and potential strategies for its manipulation. FX, a key component of the blood coagulation system, is a zymogen of a vitamin K-dependent serine protease that is primarily synthesised in the liver and circulates in the bloodstream at 8-10 μg/ml. It is composed of a light chain consisting of a domain rich in γ-carboxylated glutamic acid (Gla) residues, two epidermal growth factor-like domains and a serine protease (SP) heavy chain. The Gla domain of FX binds to the virion by docking in the cup formed by each hexon trimer, whilst the SP domain tethers the Ad5:FX complex to the hepatocyte surface through binding HSPGs. Previously, it was demonstrated that pharmacological blockade of the heparin-binding proexosite (HBPE) in the SP domain prevents FX-mediated cell binding. Here, the specific residues of FX which mediate Ad5 attachment to HSPGs were identified. Employing mutagenesis techniques each of the seven basic residues R93, K96, R125, R165, K169, K236 and R240 that were previously shown to bind heparin, were converted to alanine. This mutated FX was termed “SP mutant”. Stable cell lines were generated to constitutively produce the wild-type and SP mutant rFX protein in the presence of vitamin K. The conditioned media was affinity purified using a FX specific mouse monoclonal antibody 4G3 coupled to sepharose. The rFX proteins were quantified by ELISA, had the predicted molecular weight of 59 kDa and were biologically active, as shown by conversion to FXa in the presence of tissue factor and FVIIa. Surface plasmon resonance (SPR) analysis demonstrated the SP mutations had no effect on FX-specific binding to the Ad5 hexon. However the proexosite mutations ablated FX-mediated Ad5 cell surface binding, internalisation, cytosolic transport and gene transfer as shown by confocal microscopy, qPCR and quantification of transgene expression. Assessing the involvement of rFX with single (R125A) and double (R93A_K96A, R165A_K169A and K236A_R240A) point mutations in the SP domain, indicated the residues exhibit different levels of contribution to Ad5:FX complex binding to HSPGs. The seven SP mutations also inhibited FX-mediated Ad5 binding to mouse liver sections ex vivo. Taken together, this study uncovered that basic residues within the HBPE of FX have a fundamental role in Ad5:FX complex engagement with HSPGs at the surface of target cells. This study contributes to the existing knowledge of the FX-mediated Ad5 transduction pathway. Whilst the classical in vitro CAR-mediated Ad5 infection mechanism has been extensively studied, the post-binding events governing FX-mediated Ad5 intracellular transport and gene expression have not been fully characterised. This study employed a panel of small molecule inhibitors of cellular kinases in vitro to investigate cellular and signalling events occurring during FX-mediated Ad5 infection. Blockade of protein kinase A, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase significantly hindered efficient Ad5 intracellular trafficking and colocalisation with the microtubule organising centres (MTOC), as shown by confocal microscopy, indicating their fundamental involvement in the pathway. Screening a library of 80 diverse kinase inhibitors for effects on FX-mediated gene transfer, highlighted the compound ER-27319 had the ability to prevent Ad5 transduction in vitro. Previous work reported that ER-27319 acts by binding to the immunoreceptor tyrosine based activation motif (ITAM) of the FcεRI receptor gamma subunit in mast cells to prevent spleen tyrosine kinase (Syk) activation. Here, this compound had no effect on FX-mediated cell binding but substantially disrupted intracellular transport at 3 h in the absence of toxicity. It was postulated that this effect may be due to ER-27319 binding to a viral or cellular ITAM-containing protein involved in viral trafficking. Sequence analysis of the Ad capsid proteome for ITAM-like motifs ((D/E)-x-x-Y-x-x-(L/I)-(xn=6-8)-Y-x-x-(L/I)) identified two motifs on the hexon. However neither followed that reported for the FcεRI gamma subunit, instead of the conventional 6-8 amino acid residues between the two Y-x-x-I/L, the hexon ITAM-like sequences expressed 17 or 22 amino acids. Alternatively the ITAM-containing cellular proteins, ezrin, radixin and moesin (ERM) were investigated. The ERM family are key regulators of the cell cortex, capable of interacting with both the plasma membrane and filamentous actin. However, in the time frame imposed by this study this hypothesis could not be studied in depth, but warrants further research to investigate whether ERM proteins have a novel role in FX-mediated Ad5 intracellular trafficking. A wide range of approaches have been investigated to detarget Ad5 from the liver. In this thesis, a pharmacological strategy to preclude FX-mediated liver gene transfer was implemented. A high throughput screening platform was developed to identify a novel small molecule(s) to manipulate the Ad5:FX infection pathway. In addition to the value of such an agent in the gene therapy setting, it may also have potential to treat life-threatening disseminated Ad infections in immunocompromised individuals. Using a fluorescence and cell-based in vitro high throughput assay 10,240 small molecules were screened using the Pharmacological Diversity Drug-like Set library. Initial screening identified 288 compounds that reduced FX-mediated Ad5 gene transfer by > 75% without causing toxicity. Upon further analysis, three compounds, T5424837, T5550585 and T5660138 were identified as consistently ablating Ad5 transduction both in the absence and presence of FX and all had IC50 values < 5.5 μM. These compounds did not directly interfere with Ad5 binding to FX, instead they primarily caused a post-binding stage block of the Ad infection pathway and all affected optimal virus trafficking to the MTOC, as demonstrated by SPR, flow cytometry and confocal microscopy. The candidate molecules have common structural features and fall into the “one pharmacophore” model. Focused mini-libraries were generated relating to these molecules and structure-activity relationship analysis was performed. In vitro screening of the analogues revealed novel hits with similar or improved activity, thereby further validating the initial hits and pharmacophore model. Six compounds, T5550585, its analogue T5572402, T5660138, its analogue T5660136, T5424837 and its analogue T5677956 were tested in vivo. 10 μM T5660138 substantially reduced Ad5 liver accumulation 48 h post-injection and, in addition to its closely related analogue T5660136, significantly reduced transgene expression at 48 h post-intravenous administration of a high viral dose (1 x 1011 vp/mouse). Therefore, this study identifies novel small molecule inhibitors of circulating Ad5 infection. Through investigation and manipulation of Ad5 interactions with host proteins the work presented here, increases the understanding of the key in vivo Ad5:FX tropism determining pathway. In summary, in this thesis the mechanism of FX-mediated Ad5 complex binding to hepatocytes was dissected and potent inhibitors of this important Ad5 infectivity pathway both in vitro and in vivo were identified. This data may contribute to the optimisation of Ad vectors for gene therapy applications and potentially the advancement of anti-adenoviral drug development.

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3

"Reflex motorneuron excitability of the musculocutaneous nerve in the biceps brachii muscle after upper cervical or cervicothoracic spinal manipulative therapy". Thesis, 2009. http://hdl.handle.net/10210/2671.

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4

"A treatment protocol for the treatment of cervical facet syndrome comparing the use of cryotherapy before or after the chiropractic adjustment". Thesis, 2009. http://hdl.handle.net/10210/2679.

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"The effects of chiropractic spinal manipulation on driver club head speeds of asymptomatic amateur golfers". Thesis, 2009. http://hdl.handle.net/10210/2695.

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White, Stuart J. "A study to determine the role of soft tissue therapy in the chiropractic management of cervical facet syndrome". Thesis, 2009. http://hdl.handle.net/10210/2646.

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Stacey, Leandra R. "An investigation to determine whether the combination of a hip mobilisation and sacroiliac adjustment or a hip mobilisation alone is more effective in the treatment of osteoarthritis of the hip". Thesis, 2009. http://hdl.handle.net/10210/2688.

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Swartz, Brett. "The immediate effect of cervicothoracic junction manipulation on triceps muscle strength". Thesis, 2009. http://hdl.handle.net/10210/2689.

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Sher, Gregory Colin. "The effect of sacroiliac joint manipulation on quadriceps muscle strength". Thesis, 2009. http://hdl.handle.net/10210/2694.

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10

Herwill, Dylan Marc. "A study of the effect of chiropractic adjustment therapy of the tibiotalar joint and strengthening of the gastrocnemius muscle". Thesis, 2010. http://hdl.handle.net/10210/3136.

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M. Tech.
The aim of this study was to determine whether a combination treatment of strength training of the Gastrocnemius muscle and adjusting of the Tibiotalar joint would have a greater effect and influence on the strength of the Gastrocnemius muscles when compared to either strengthening the Gastrocnemius muscles or adjusting the Tibiotalar joints alone. Thirty participants from the surrounding community of the University of Johannesburg were randomly divided into one of three groups, with an equal male to female ratio within each group. Group A received a strength training protocol directed at the Gastrocnemius muscles. Group B received Chiropractic adjustment therapy directed at the Tibiotalar joints and Group C received a combination of a strength training protocol of the Gastrocnemius muscles in addition to Chiropractic adjustment therapy directed at the Tibiotalar joints. All three groups received 6 treatments on alternate days over a two week period. Objective data was collected by means of a surface Electromyograph (sEMG) taken pre- and post-treatment on the 1st, 3rd and 6th appointments, and muscle strength testing was measured using an Isometric Dynamometer post-treatment on the 1st, 3rd and 6th appointments. Demographic data was collected and evaluated from the Case History, Pertinent Physical Examination, Demographic Data Questionnaire and Physical Assessment Form. In executing the comparison, it was anticipated that all three groups would be effective, but the group undergoing the combination treatment would have the best improvement on the Gastrocnemius strength overall, followed by the adjustment group and then the strengthening group. It could then be concluded that Chiropractic adjustment therapy would provide a safe, cost effective treatment and preventative measure of injury to the Gastrocnemius muscles. Treatment proposed in this research could thus serve as an adjunct and preventative therapy in current rehabilitation treatment protocols in athletes as well as in the general public. The results obtained from the study demonstrated that there was no statistically significant improvement in either of the groups however, there was a definite effect from the treatment protocols in each group that would warrant further investigation. There is a definite link between adjusting the Tibiotalar joint and affecting the Gastrocnemius muscle. Therefore, treating the joint can help the Gastrocnemius muscle to reach its optimal functionality. In conclusion, the study showed that Chiropractic adjustment therapy of the Tibiotalar joint and strengthening of the Gastrocnemius muscles had a combination effect on its strength and endurance that was greater than either of the treatments alone. From these results, it would be prudent to incorporate this treatment protocol to serve as an adjunctive therapy in rehabilitation and training protocols.

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Livros sobre o assunto "Manipulation (Therapeutics)"

1

C, Gordon Robert, ed. Manipulation under anesthesia: Concepts in theory and application. Boca Raton, FL: CRC Press, 2005.

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2

Fred, Hoehler, ed. Musculoskeletal manipulation: Evaluation of the scientific evidence. Springfield, Ill., U.S.A: Thomas, 1986.

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3

Jennie, Longbottom, ed. Acupuncture in manual therapy. Edinburgh: Churchill Livingstone, 2010.

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4

Jinxue, Li. Chinese manipulation and massage: Chinese manipulative therapy (CMT). Oxford [England]: International Academic Publishers, 1990.

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5

Byfield, David. Technique skills in chiropractic. Edinburgh: Churchill Livingstone/Elsevier, 2012.

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6

Nathan, Bevis. Touch and emotion in manual therapy. Edinburgh: Churchill Livingstone, 1999.

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7

Maitland, G. D. Peripheral manipulation. 3^a ed. Oxford: Butterworth-Heinemann, 1999.

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8

Hebgen, Eric. Visceral manipulation in osteopathy. Stuttgart: Thieme, 2011.

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9

Beeton, Karen. The peripheral joints. Edinburgh: Churchill Livingstone, 2003.

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10

D, Maitland G., ed. Maitland's vertebral manipulation. 6^a ed. Oxford: Butterworth-Heinemann, 2001.

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Capítulos de livros sobre o assunto "Manipulation (Therapeutics)"

1

Cook, John R., Kaylee V. Bennett, Michael C. Barton e Steven M. Platek. "SARS/CoV-2: Behavioral Host Manipulation". In Coronavirus Therapeutics – Volume II, 71–80. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-85113-2_4.

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2

Mollnes, Tom Eirik. "Therapeutic Manipulation of the Complement System". In The Complement System, 483–516. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/1-4020-8056-5_23.

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3

Kadian, Monika, e Anil Kumar. "Psychobiotics for Manipulating Gut–Brain Axis in Alzheimer’s Disease". In Probiotic Research in Therapeutics, 135–53. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6760-2_6.

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4

von der Leyen, H. E., e V. J. Dzau. "Therapeutic Potential of Nitric Oxide Synthase Gene Manipulation". In Nitric Oxide, 639–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57077-3_25.

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Ali, Mudassar, Jyotirmoy Rajurkar, Priyanka Majumder, Mainak Pratim Jha, Rajasri Sarkar e Koyeli Mapa. "Possible Therapeutic Intervention Strategies for COVID-19 by Manipulating the Cellular Proteostasis Network". In Coronavirus Therapeutics – Volume I, 125–47. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-85109-5_8.

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6

Charron, Maureen J., e Ellen B. Katz. "Metabolic and therapeutic lessons from genetic manipulation of GLUT4". In Insulin Action, 143–52. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_15.

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Watson, Alastair, e Pedro Lowenstein. "Therapeutic manipulation of apoptosis in cancer and neurological disease". In Apoptosis Genes, 281–303. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5287-1_10.

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Henderson, I. C. "State of the art in cytotoxic manipulation in treatment of metastatic breast cancer". In Therapeutic Management of Metastatic Breast Cancer, editado por M. Kaufmann, I. C. Henderson e E. Enghofer, 19–32. Berlin, Boston: De Gruyter, 1989. http://dx.doi.org/10.1515/9783110888942-003.

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9

Shephard, J., S. Brett e T. W. Evans. "Therapeutic Manipulation of the Pulmonary Circulation in Acute Lung Injury". In Yearbook of Intensive Care and Emergency Medicine, 311–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79154-3_25.

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10

Sinha, Lovely, e Saurabh Karmakar. "Traditional Herbal Medicines, Bioactive Compounds, and Plant Products as Therapeutic Approach Against Interstitial Lung Disease". In Genetic Manipulation of Secondary Metabolites in Medicinal Plant, 339–80. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-4939-7_15.

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Trabalhos de conferências sobre o assunto "Manipulation (Therapeutics)"

1

Nguyen, Van Du, Shaohui Zheng, Viet Ha Le, Jiwon Han e Jong-Oh Park. "Manipulation of tumor targeting cell-based microrobots carrying NIR light sensitive therapeutics using EMA system and chemotaxis". In 2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS). IEEE, 2017. http://dx.doi.org/10.1109/marss.2017.8001911.

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Batabyal, Subrata, Sanghoon Kim, Michael Carlson, Houssam Al-Saad, Jazlyn Gallego, Adnan Dibas e Samarendra K. Mohanty. "Neuroprotection by optical delivery of therapeutic gene into retina". In Optogenetics and Optical Manipulation 2021, editado por Samarendra K. Mohanty, Anna W. Roe e Shy Shoham. SPIE, 2021. http://dx.doi.org/10.1117/12.2586104.

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Julias, Margaret, Helen M. Buettner e David I. Shreiber. "The Biophysical Response of Collagen-Fibrin Composite Gels to In Vitro Acupuncture". In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19221.

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Therapeutic acupuncture involves the insertion and manipulation of fine needles at specific points. Although acupuncture has been proven effective for a number of conditions, the mechanisms that underlay these effects remain unknown. A critical first step is to identify the local changes that occur during needle manipulation, which can then be related to longer-term and more remote consequences. In vivo and ex vivo studies have demonstrated that loose collagenous subcutaneous connective tissue couples to needles during therapeutic manipulation, which deforms the tissue and exposes resident cells to altered mechanics and triggers morphologic and phenotypic changes. The resultant alignment of the tissue and cells may additionally help to propagate signals along acupuncture meridians.

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Miron, Geneviève, Alexandre Girard, Jean-Sébastien Plante e Martin Lepage. "Design and Manufacturing of Embedded Pneumatic Actuators for an MRI-Compatible Prostate Cancer Binary Manipulator". In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-71380.

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Magnetic Resonance Imaging (MRI) compatible robots can assist physicians in precisely inserting biopsy needles or therapeutic instruments directly into millimeter-size tumors using MR imaging feedback. MRI systems although present a challenging environment, including high magnetic fields and limited space, making the development of MRI-compatible robots complex. This paper presents an MRI-compatible pneumatic actuation technology consisting of molded polymer structures with embedded air-muscle, operated in a binary fashion. While having good positioning accuracy, the technology presents advantages of compactness, perfect MRI-compatibility, simplicity, and low cost. Here we specifically report the design and validation of a transperineal prostate cancer manipulator prototype having 20 embedded air-muscles distributed in four star-like polymer structures. Structures are made of silicone elastomer, using lost-core injection molding. The molded compliant joints of the muscles eliminate sliding surfaces, for low motion hysteresis and good repeatability. A simple and effective two-level design method for polymer air-muscles is proposed, using a manipulator model and three muscle models: geometrical, finite elements and uniaxial analytic. Binary control of each air-muscle assures stability and accuracy with minimized costs and complexity. The manipulator is tested MRI-compatible with no effects on the signal-to-noise ratio and, with appropriate image feedback, reaches targets with repeatability and accuracy under 0.5 mm. The embedded approach reveals to be a key feature since it reduces hysteresis errors by a factor of 6.6 compared to a previous non-embedded version of the manipulator. The successful validation of this binary manipulator opens the door to a new design paradigm for low cost and highly capable pneumatic robots, specifically for the intra-MRI manipulation.

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Gao, Shiqiang, e Georg Nagel. "Development and applications of Optogenetic tools for manipulation of cyclic nucleotides". In cGMP: Generators, Effectors and Therapeutic Implications. ScienceOpen, 2024. http://dx.doi.org/10.14293/cgmp.24000051.v1.

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Finlay, P. A. "Robotic controlled endoscopic manipulator". In IEE Colloquium on Technological Advances in Therapeutic Urology. IEE, 1996. http://dx.doi.org/10.1049/ic:19960626.

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Ort, Teddy, Faye Wu, Nicholas C. Hensel e H. Harry Asada. "Supernumerary Robotic Fingers as a Therapeutic Device for Hemiparetic Patients". In ASME 2015 Dynamic Systems and Control Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/dscc2015-9945.

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Patients with hemiparesis often have limited functionality in the left or right hand. The standard therapeutic approach requires the patient to attempt to make use of the weak hand even though it is not functionally capable, which can result in feelings of frustration. Furthermore, hemiparetic patients also face challenges in completing many bimanual tasks, for example walker manipulation, that are critical to patients’ independence and quality of life. A prototype therapeutic device with two supernumerary robotic fingers was used to determine if robotic fingers could functionally assist a human in the performance of bimanual tasks by observing the pose of the healthy hand. Specific focus was placed on the identification of a straightforward control routine which would allow a patient to carry out simple manipulation tasks with some intermittent input from a therapist. Part of this routine involved allowing a patient to switch between active and inactive monitoring of hand position, resulting in additional manipulation capabilities. The prototype successfully enabled a test subject to complete various bimanual tasks using the robotic fingers in place of normal hand motions. From these results, it is clear that the device could allow a hemiparetic patient to complete tasks which would previously have been impossible to perform.

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Deng, Chongli, Jian Li, Xuewei Cao, Jun Liu, Tao Yu e Da Guo. "Therapeutic effectiveness evaluation on Shishi manipulation for knee osteoarthritis". In 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW). IEEE, 2012. http://dx.doi.org/10.1109/bibmw.2012.6470376.

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Zheng, Shaohui, Sunghoon Cho, Van Du Nguyen, Eunpyo Choi, Jiwon Han e Jong-Oh Park. "Development of hyaluronic acid microcargo for therapeutic bacteriobots". In 2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS). IEEE, 2017. http://dx.doi.org/10.1109/marss.2017.8001912.

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Brewer, B. R., R. Klatzky e Y. Matsuoka. "Initial Therapeutic Results of Visual Feedback Manipulation in Robotic Rehabilitation". In 2006 International Workshop on Virtual Rehabilitation. IEEE, 2006. http://dx.doi.org/10.1109/iwvr.2006.1707546.

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Relatórios de organizações sobre o assunto "Manipulation (Therapeutics)"

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Research, Gratis. Green Light: A New Preventive Therapy for Migraine. Gratis Research, novembro de 2020. http://dx.doi.org/10.47496/gr.blog.03.

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Manipulating the ability of green light to create the least amount of electrical signals in retina and brain cortex, green light therapy offers an excellent therapeutic role in reducing migraine pain and improves the quality of life

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Yull, Fiona E. Manipulation of NF-KappaB Activity in the Macrophage Lineage as a Novel Therapeutic Approach. Fort Belvoir, VA: Defense Technical Information Center, maio de 2005. http://dx.doi.org/10.21236/ada439787.

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Yull, Fiona. Manipulation of Nf-KappaB Activity in the Macrophage Lineage as a Novel Therapeutic Approach. Fort Belvoir, VA: Defense Technical Information Center, maio de 2008. http://dx.doi.org/10.21236/ada487648.

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Yull, Fiona E. Manipulation of NF-KappaBetta Activity in the Macrophage Lineage as a Novel Therapeutic Approach. Fort Belvoir, VA: Defense Technical Information Center, maio de 2007. http://dx.doi.org/10.21236/ada471493.

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