Literatura científica selecionada sobre o tema "Malaria virulence"
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Artigos de revistas sobre o assunto "Malaria virulence"
Lin, Jing-wen, Adam J. Reid, Deirdre Cunningham, Ulrike Böhme, Irene Tumwine, Sara Keller-Mclaughlin, Mandy Sanders, Matthew Berriman e Jean Langhorne. "Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern". Wellcome Open Research 3 (2 de novembro de 2018): 142. http://dx.doi.org/10.12688/wellcomeopenres.14797.1.
Texto completo da fonteLin, Jing-wen, Adam J. Reid, Deirdre Cunningham, Ulrike Böhme, Irene Tumwine, Sara Keller-Mclaughlin, Mandy Sanders, Matthew Berriman e Jean Langhorne. "Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern". Wellcome Open Research 3 (6 de dezembro de 2018): 142. http://dx.doi.org/10.12688/wellcomeopenres.14797.2.
Texto completo da fonteDeitsch, Kirk W. "Malaria Virulence Genes". Cell 121, n.º 1 (abril de 2005): 1–2. http://dx.doi.org/10.1016/j.cell.2005.03.019.
Texto completo da fonteSchneider, Petra, Andrew S. Bell, Derek G. Sim, Aidan J. O'Donnell, Simon Blanford, Krijn P. Paaijmans, Andrew F. Read e Sarah E. Reece. "Virulence, drug sensitivity and transmission success in the rodent malaria, Plasmodium chabaudi". Proceedings of the Royal Society B: Biological Sciences 279, n.º 1747 (26 de setembro de 2012): 4677–85. http://dx.doi.org/10.1098/rspb.2012.1792.
Texto completo da fontePenman, Bridget, e Sunetra Gupta. "Evolution of virulence in malaria". Journal of Biology 7, n.º 6 (2008): 22. http://dx.doi.org/10.1186/jbiol83.
Texto completo da fonteMackinnon, Margaret J., e Andrew F. Read. "Virulence in malaria: an evolutionary viewpoint". Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 359, n.º 1446 (29 de junho de 2004): 965–86. http://dx.doi.org/10.1098/rstb.2003.1414.
Texto completo da fonteMetcalf, C. J. E., G. H. Long, N. Mideo, J. D. Forester, O. N. Bjørnstad e A. L. Graham. "Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply". Journal of The Royal Society Interface 9, n.º 76 (20 de junho de 2012): 2804–13. http://dx.doi.org/10.1098/rsif.2012.0340.
Texto completo da fonteNunes-Alves, Cláudio. "Linking virulence and transmission in malaria". Nature Reviews Microbiology 12, n.º 10 (8 de setembro de 2014): 655. http://dx.doi.org/10.1038/nrmicro3354.
Texto completo da fonteMancio-Silva, Liliana, Ksenija Slavic, Margarida T. Grilo Ruivo, Ana Rita Grosso, Katarzyna K. Modrzynska, Iset Medina Vera, Joana Sales-Dias et al. "Nutrient sensing modulates malaria parasite virulence". Nature 547, n.º 7662 (julho de 2017): 213–16. http://dx.doi.org/10.1038/nature23009.
Texto completo da fonteChookajorn, Thanat, Ron Dzikowski, Matthias Frank, Felomena Li, Alisha Z. Jiwani, Daniel L. Hartl e Kirk W. Deitsch. "Epigenetic memory at malaria virulence genes". Proceedings of the National Academy of Sciences 104, n.º 3 (5 de janeiro de 2007): 899–902. http://dx.doi.org/10.1073/pnas.0609084103.
Texto completo da fonteTeses / dissertações sobre o assunto "Malaria virulence"
Long, Gráinne Helen. "Immunopathology and virulence evolution in rodent malaria". Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/1962.
Texto completo da fontePettersson, Fredrik. "Sequestration, virulence and future interventions in Plasmodium falciparum malaria". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-568-2/.
Texto completo da fonteHeddini, Andreas. "Endothelial cytoadherence, rosetting and virulence in Plasmodium falciparum malaria /". Stockholm : [Karolinska institutets bibl.], 2001.
Encontre o texto completo da fonteTimms, Rebecca. "The ecology and evolution of virulence in mixed infections of malaria parasites". Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/13132.
Texto completo da fonteFerguson, Heather M. "The ecology and evolutionary implications of malaria parasite virulence in mosquito vectors". Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/14838.
Texto completo da fonteBarclay, Victoria Charlotte. "Studies evaluating the possible evolution of malaria parasites in response to blood-stage vaccination". Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3996.
Texto completo da fonteVardo-Zalik, Anne. "Clonal Diversity of the Malaria Parasite Plasmodium Mexicanum: Diversity Over Time and Space, and Effects on the Parasite’s Transmission, Infection Dynamics and Virulence". ScholarWorks @ UVM, 2008. http://scholarworks.uvm.edu/graddis/234.
Texto completo da fonteCellier-Holzem, Elise. "Ecologie évolutive de la malaria aviaire : approches expérimentales des relations entre Plasmodium relictum et le canari domestique". Phd thesis, Université de Bourgogne, 2010. http://tel.archives-ouvertes.fr/tel-00665065.
Texto completo da fonteDiffendall, Gretchen. "Deciphering the role of an RNA Pol III-transcribed non-coding RNA in Plasmodium falciparum". Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS443.pdf.
Texto completo da fonteThe protozoan parasite Plasmodium falciparum is the causative agent of the deadliest form of human malaria. This pathogen uses monoallelic expression of variant surface adhesion molecules, encoded by the var gene family, to evade the host immune system and cause pathogenesis. It remains unclear how monoallelic expression of var gene activation works at the molecular level and if environmental factors can modulate var gene expression. Our laboratory showed a Pol III transcribed GC-rich non-coding RNA gene family, termed RUF6, acts as a trans-activator of var genes. A physical association between the transcribed RUF6 ncRNA and the active var gene locus was observed through FISH. Transcriptional repression of all RUF6 by a specific CRISPR interference strategy resulted in transcriptional down regulation of the entire var gene family, suggesting a potential enhancer-like function to var gene expression. An understanding of how RUF6 ncRNA mediates var gene activation is lacking. Here we developed a robust RNA-directed proteomic discovery (ChIRP-MS) protocol to identify in vivo RUF6 ncRNA protein interactions. Biotinylated antisense oligonucleotides were used to purify the RUF6 ncRNA interactome. Mass spectrometry identified several uniquely enriched proteins that are linked to gene transcription such as RNA Pol II subunits, nucleosome assembly proteins, and a homologue of the Dead-Box Helicase 5 (DDX5). Affinity purification of PfDDX5 identified several proteins originally found by our RUF6-ChIRP protocol, validating the robustness of the technique for the identification of ncRNA interactomes in P. falciparum. Inducible displacement of nuclear Pf-DDX5 resulted in the significant down-regulation of the active var gene. Our work identifies a RUF6 ncRNA protein complex that interacts with RNA Pol II to sustain var gene expression. We postulate that DDX5 helicase may resolve G-quadruplex secondary structures highly enriched in var genes to facilitate transcriptional activation and progression. Furthermore, we discovered environmental factors that trigger downregulation of var gene transcription. We observe that isoleucine starvation and high MgCl2 concentrations in the medium inhibit RNA Polymerase III transcribed genes. Importantly, this includes a P. falciparum-specific regulatory ncRNA gene family (encoded by the RUF6 gene family) that is a key regulator in var gene activation. We identified a homologous gene to the highly conserved eukaryotic Maf1, as a negative effector of RUF6 ncRNA transcription. Elevated MgCl2 concentrations led to a shift of cytoplasmic PfMaf1 to the nuclear compartment. We used an inducible protein degradation system to show that external stimuli depend on PfMaf1 to trigger lower expression of RUF6 genes. Our results point to a TOR independent pathway that responds to changes in the environment and represses Pol III transcription. This work provides new and important conceptual insights into PfMaf1-dependent repression of parasite virulence that may be highly relevant for establishing subclinical parasite persistence in the dry season. Taken together, these results help to better understand the function and regulation of a ncRNA involved in regulating the antigenic variation and pathogenesis in P. falciparum. Our validation of the ChIRP-MS technique allows for future studies in identifying RNA-binding proteins for ncRNAs whose function remains to be fully characterized
Neal, Aaron T. "Identifying genetic determinants of impaired PfEMP1 export in Plasmodium falciparum-infected erythrocytes". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:0cc3f09c-9178-448b-92f8-8f9564398585.
Texto completo da fonteCapítulos de livros sobre o assunto "Malaria virulence"
Escalante, Ananias A., e Francisco J. Ayala. "Malaria: Host Range, Diversity, and Speciation". In Evolution of Virulence in Eukaryotic Microbes, 91–110. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118308165.ch5.
Texto completo da fonteSu, Xin-Zhuan, e John C. Wootton. "Selective Sweeps in Human Malaria Parasites". In Evolution of Virulence in Eukaryotic Microbes, 124–42. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118308165.ch7.
Texto completo da fonteSmith, Joseph, e Kirk W. Deitsch. "Antigenic Variation, Adherence, and Virulence in Malaria". In Evolution of Virulence in Eukaryotic Microbes, 338–61. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118308165.ch18.
Texto completo da fonteDuraisingh, Manoj T., Jeffrey D. Dvorin e Peter R. Preiser. "Invasion Ligand Diversity and Pathogenesis in Blood-Stage Malaria". In Evolution of Virulence in Eukaryotic Microbes, 362–83. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118308165.ch19.
Texto completo da fonteVolkman, Sarah K., Daniel E. Neafsey, Stephen F. Schaffner, Pardis C. Sabeti e Dyann F. Wirth. "From Population Genomics to Elucidated Traits inPlasmodium Falciparum: Population Genomics, Genetic Diversity, and Association in Malaria". In Evolution of Virulence in Eukaryotic Microbes, 111–23. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118308165.ch6.
Texto completo da fonteCarter, Richard, e Richard Culleton. "Genetic Mapping of Virulence in Rodent Malarias". In Evolution of Virulence in Eukaryotic Microbes, 269–84. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118308165.ch14.
Texto completo da fonteTsegaye Tseha, Sintayehu. "Plasmodium Species and Drug Resistance". In Plasmodium Species and Drug Resistance [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98344.
Texto completo da fonteGupta, Sunetra, e Karen Day. "Virulence and transmissibility in P. falciparum malaria". In Models for Infectious Human Diseases, 160–80. Cambridge University Press, 1996. http://dx.doi.org/10.1017/cbo9780511662935.018.
Texto completo da fonteEwald, Paul W. "Vectors, Vertical Transmission, and the Evolution of Virulence". In Evolution of Infectious Disease, 35–56. Oxford University PressNew York, NY, 1994. http://dx.doi.org/10.1093/oso/9780195060584.003.0003.
Texto completo da fonte"Malaria Parasite Virulence in Mosquitoes and Its Implications for the Introduction and Efficacy of GMM Malaria Control Programmes". In Genetically Modified Mosquitoes for Malaria Control, 119–32. CRC Press, 2006. http://dx.doi.org/10.1201/9781498712866-13.
Texto completo da fonteTrabalhos de conferências sobre o assunto "Malaria virulence"
Miranda Mas, Carlos. "Arte vs turistificación: Souvenirs de resistencia". In V Congreso Internacional de Investigacion en Artes Visuales ANIAV 2022. RE/DES Conectar. València: Editorial Universitat Politècnica de València, 2022. http://dx.doi.org/10.4995/aniav2022.2022.15485.
Texto completo da fonteRelatórios de organizações sobre o assunto "Malaria virulence"
McElwain, Terry F., Eugene Pipano, Guy H. Palmer, Varda Shkap, Stephn A. Hines e Wendy C. Brown. Protection of Cattle against Babesiosis: Immunization against Babesia bovis with an Optimized RAP-1/Apical Complex Construct. United States Department of Agriculture, setembro de 1999. http://dx.doi.org/10.32747/1999.7573063.bard.
Texto completo da fonteLignes directrices pour le contrôle et la prévention de la peste des petits ruminants (PPR) dans les populations de faune sauvage. OIE (World Organisation for Animal Health), dezembro de 2021. http://dx.doi.org/10.20506/ppr.3274.
Texto completo da fonte