Artigos de revistas sobre o tema "Ligand/substrate identification"
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Singh, Manvi, Priya Kempanna e Kavitha Bharatham. "Identification of Mtb GlmU Uridyltransferase Domain Inhibitors by Ligand-Based and Structure-Based Drug Design Approaches". Molecules 27, n.º 9 (28 de abril de 2022): 2805. http://dx.doi.org/10.3390/molecules27092805.
Texto completo da fonteRothweiler, Elisabeth M., Paul E. Brennan e Kilian V. M. Huber. "Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators". Biological Chemistry 403, n.º 4 (23 de fevereiro de 2022): 391–402. http://dx.doi.org/10.1515/hsz-2021-0396.
Texto completo da fonteFernández, Rico-Jiménez, Ortega, Daddaoua, García García, Martín-Mora, Torres, Tajuelo, Matilla e Krell. "Determination of Ligand Profiles for Pseudomonas aeruginosa Solute Binding Proteins". International Journal of Molecular Sciences 20, n.º 20 (17 de outubro de 2019): 5156. http://dx.doi.org/10.3390/ijms20205156.
Texto completo da fonteWang, Wenyuan, Junli Zhu, Qi Huang, Lei Zhu, Ding Wang, Weimin Li e Wenjie Yu. "DFT Exploration of Metal Ion–Ligand Binding: Toward Rational Design of Chelating Agent in Semiconductor Manufacturing". Molecules 29, n.º 2 (8 de janeiro de 2024): 308. http://dx.doi.org/10.3390/molecules29020308.
Texto completo da fonteWeng, Z., S. M. Thomas, R. J. Rickles, J. A. Taylor, A. W. Brauer, C. Seidel-Dugan, W. M. Michael, G. Dreyfuss e J. S. Brugge. "Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains". Molecular and Cellular Biology 14, n.º 7 (julho de 1994): 4509–21. http://dx.doi.org/10.1128/mcb.14.7.4509-4521.1994.
Texto completo da fonteWeng, Z., S. M. Thomas, R. J. Rickles, J. A. Taylor, A. W. Brauer, C. Seidel-Dugan, W. M. Michael, G. Dreyfuss e J. S. Brugge. "Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains." Molecular and Cellular Biology 14, n.º 7 (julho de 1994): 4509–21. http://dx.doi.org/10.1128/mcb.14.7.4509.
Texto completo da fonteEvans, S. W., D. Rennick e W. L. Farrar. "Identification of a signal-transduction pathway shared by haematopoietic growth factors with diverse biological specificity". Biochemical Journal 244, n.º 3 (15 de junho de 1987): 683–91. http://dx.doi.org/10.1042/bj2440683.
Texto completo da fonteDuarte Filho, Luiz Antonio Miranda de Souza, Cintia Emi Yanaguibashi Leal, Pierre-Edouard Bodet, Edilson Beserra de Alencar Filho, Jackson Roberto Guedes da Silva Almeida, Manon Porta Zapata, Oussama Achour et al. "The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fucus ceranoides L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy". Marine Drugs 22, n.º 6 (27 de maio de 2024): 244. http://dx.doi.org/10.3390/md22060244.
Texto completo da fonteDrexler, Hannes C. A., Matthias Vockel, Christian Polaschegg, Maike Frye, Kevin Peters e Dietmar Vestweber. "Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2". Molecular & Cellular Proteomics 18, n.º 10 (19 de agosto de 2019): 2058–77. http://dx.doi.org/10.1074/mcp.ra119.001716.
Texto completo da fonteLamaze, C., e S. L. Schmid. "Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase." Journal of Cell Biology 129, n.º 1 (1 de abril de 1995): 47–54. http://dx.doi.org/10.1083/jcb.129.1.47.
Texto completo da fonteMora Lagares, Liadys, Yunierkis Pérez-Castillo, Nikola Minovski e Marjana Novič. "Structure–Function Relationships in the Human P-Glycoprotein (ABCB1): Insights from Molecular Dynamics Simulations". International Journal of Molecular Sciences 23, n.º 1 (29 de dezembro de 2021): 362. http://dx.doi.org/10.3390/ijms23010362.
Texto completo da fonteRuan, Ke-He. "High resolution nuclear magnetic resonance spectroscopy-guided mutagenesis for characterization of membrane-bound proteins: Experimental designs and applications". Spectroscopy 18, n.º 1 (2004): 13–29. http://dx.doi.org/10.1155/2004/802728.
Texto completo da fonteReynolds, A. B., J. Daniel, P. D. McCrea, M. J. Wheelock, J. Wu e Z. Zhang. "Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes". Molecular and Cellular Biology 14, n.º 12 (dezembro de 1994): 8333–42. http://dx.doi.org/10.1128/mcb.14.12.8333-8342.1994.
Texto completo da fonteReynolds, A. B., J. Daniel, P. D. McCrea, M. J. Wheelock, J. Wu e Z. Zhang. "Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes." Molecular and Cellular Biology 14, n.º 12 (dezembro de 1994): 8333–42. http://dx.doi.org/10.1128/mcb.14.12.8333.
Texto completo da fonteAdams, James, Benjamin P. Thornton e Lydia Tabernero. "A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis". International Journal of Molecular Sciences 22, n.º 22 (11 de novembro de 2021): 12206. http://dx.doi.org/10.3390/ijms222212206.
Texto completo da fonteYadav, Rolly, Anwesh Pandey, Nidhi Awasthi e Anamika Shukla. "Molecular Docking Studies of Enzyme Binding Drugs on Family of Cytochrome P450". Advanced Science, Engineering and Medicine 12, n.º 1 (1 de janeiro de 2020): 83–87. http://dx.doi.org/10.1166/asem.2020.2520.
Texto completo da fonteBARNETT, Stanley F., Deborah DEFEO-JONES, Sheng FU, Paula J. HANCOCK, Kathleen M. HASKELL, Raymond E. JONES, Jason A. KAHANA et al. "Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors". Biochemical Journal 385, n.º 2 (7 de janeiro de 2005): 399–408. http://dx.doi.org/10.1042/bj20041140.
Texto completo da fonteWei, Min, Richard Wynn, Gregory Hollis, Boshan Liao, Alexander Margulis, Brian G. Reid, Ronald Klabe et al. "High-Throughput Determination of Mode of Inhibition in Lead Identification and Optimization". Journal of Biomolecular Screening 12, n.º 2 (11 de janeiro de 2007): 220–28. http://dx.doi.org/10.1177/1087057106296679.
Texto completo da fonteTakeuchi, Hajime, Daniel J. Rigden, Bahram Ebrahimi, Philip C. Turner e Huw H. Rees. "Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration". Biochemical Journal 389, n.º 3 (26 de julho de 2005): 637–45. http://dx.doi.org/10.1042/bj20050498.
Texto completo da fonteD’Arrigo, Giulia, Ida Autiero, Eleonora Gianquinto, Lydia Siragusa, Massimo Baroni, Gabriele Cruciani e Francesca Spyrakis. "Exploring Ligand Binding Domain Dynamics in the NRs Superfamily". International Journal of Molecular Sciences 23, n.º 15 (5 de agosto de 2022): 8732. http://dx.doi.org/10.3390/ijms23158732.
Texto completo da fonteBasu, Nirmalya, Rashna Bhandari, Vivek T. Natarajan e Sandhya S. Visweswariah. "Cross Talk between Receptor Guanylyl Cyclase C and c-src Tyrosine Kinase Regulates Colon Cancer Cell Cytostasis". Molecular and Cellular Biology 29, n.º 19 (20 de julho de 2009): 5277–89. http://dx.doi.org/10.1128/mcb.00001-09.
Texto completo da fonteAstegno, Alessandra, Alejandro Giorgetti, Alessandra Allegrini, Barbara Cellini e Paola Dominici. "Characterization of C-S Lyase fromC. diphtheriae: A Possible Target for New Antimicrobial Drugs". BioMed Research International 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/701536.
Texto completo da fonteSanguinetti, Manuel, Lucianna Helene Silva Santos, Juliette Dourron, Catalina Alamón, Juan Idiarte, Sotiris Amillis, Sergio Pantano e Ana Ramón. "Substrate Recognition Properties from an Intermediate Structural State of the UreA Transporter". International Journal of Molecular Sciences 23, n.º 24 (16 de dezembro de 2022): 16039. http://dx.doi.org/10.3390/ijms232416039.
Texto completo da fonteXia, Daosong, Renwen Zheng, Jianhua Huang, Sihan Lu e Qingfeng Tang. "Identification and Functional Analysis of Glutathione S-Transferases from Sitophilus zeamais in Olfactory Organ". Insects 13, n.º 3 (5 de março de 2022): 259. http://dx.doi.org/10.3390/insects13030259.
Texto completo da fonteThakur, Priti, Jowad Atway, Patrick A. Limbach e Balasubrahmanyam Addepalli. "RNA Cleavage Properties of Nucleobase-Specific RNase MC1 and Cusativin Are Determined by the Dinucleotide-Binding Interactions in the Enzyme-Active Site". International Journal of Molecular Sciences 23, n.º 13 (24 de junho de 2022): 7021. http://dx.doi.org/10.3390/ijms23137021.
Texto completo da fonteMilot, Marie-Michelle, e Adrian Hofmann. "Shikimate kinase-like 1 plays an integral role in chloroplast biogenesis". Acta Crystallographica Section A Foundations and Advances 70, a1 (5 de agosto de 2014): C452. http://dx.doi.org/10.1107/s2053273314095473.
Texto completo da fonteVenkatraman, Janani, Jyothi Bhat, Suresh M. Solapure, Jatheendranath Sandesh, Debasmita Sarkar, Sundaram Aishwarya, Kakoli Mukherjee et al. "Screening, Identification, and Characterization of Mechanistically Diverse Inhibitors of the Mycobacterium Tuberculosis Enzyme, Pantothenate Kinase (CoaA)". Journal of Biomolecular Screening 17, n.º 3 (15 de novembro de 2011): 293–302. http://dx.doi.org/10.1177/1087057111423069.
Texto completo da fonteN'Diaye, Elsa-Noah, Aylin C. Hanyaloglu, Kimberly K. Kajihara, Manojkumar A. Puthenveedu, Ping Wu, Mark von Zastrow e Eric J. Brown. "The Ubiquitin-like Protein PLIC-2 Is a Negative Regulator of G Protein-coupled Receptor Endocytosis". Molecular Biology of the Cell 19, n.º 3 (março de 2008): 1252–60. http://dx.doi.org/10.1091/mbc.e07-08-0775.
Texto completo da fontePallen, C. J., D. S. Y. Lai, H. P. Chia, I. Boulet e P. H. Tong. "Purification and characterization of a higher-molecular-mass form of protein phosphotyrosine phosphatase (PTP 1B) from placental membranes". Biochemical Journal 276, n.º 2 (1 de junho de 1991): 315–23. http://dx.doi.org/10.1042/bj2760315.
Texto completo da fontePowell, David W., Madhavi J. Rane, Brian A. Joughin, Ralitsa Kalmukova, Jeong-Ho Hong, Bruce Tidor, William L. Dean et al. "Proteomic Identification of 14-3-3ζ as a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Substrate: Role in Dimer Formation and Ligand Binding". Molecular and Cellular Biology 23, n.º 15 (1 de agosto de 2003): 5376–87. http://dx.doi.org/10.1128/mcb.23.15.5376-5387.2003.
Texto completo da fonteDryuchko, Oleksandr, Natalia Bunyakina, Bogdan Korobko, Oleksandr Shefer, Kateryna Kytaihora e Iryna Ivanytska. "SEARCH FOR WAYS OF CONTROLLED MODIFICATION OF CHARACTERISTICS OF FUNCTIONAL UNITS OF ADAPTIVE AIR PURIFICATION SYSTEMS". Bulletin of the National Technical University "KhPI". Series: Chemistry, Chemical Technology and Ecology, n.º 2(6) (23 de dezembro de 2021): 34–51. http://dx.doi.org/10.20998/2079-0821.2021.02.06.
Texto completo da fonteAytenfisu, Asaminew H., Daniel Deredge, Erik H. Klontz, Jonathan Du, Eric J. Sundberg e Alexander D. MacKerell. "Insights into substrate recognition and specificity for IgG by Endoglycosidase S2". PLOS Computational Biology 17, n.º 7 (26 de julho de 2021): e1009103. http://dx.doi.org/10.1371/journal.pcbi.1009103.
Texto completo da fonteByrne, Dominic P., Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry et al. "New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors". Biochemical Journal 475, n.º 15 (14 de agosto de 2018): 2435–55. http://dx.doi.org/10.1042/bcj20180266.
Texto completo da fonteLobell, Robert B., Joseph P. Davide, Nancy E. Kohl, H. Donald Burns, Wai-Si Eng e Raymond E. Gibson. "A Cell-Based Radioligand Binding Assay for Farnesyl: Protein Transferase Inhibitors". Journal of Biomolecular Screening 8, n.º 4 (agosto de 2003): 430–38. http://dx.doi.org/10.1177/1087057103256153.
Texto completo da fonteVargas-Pérez, María de los Ángeles, Damien Paul Devos e Guillermo López-Lluch. "An AlphaFold Structure Analysis of COQ2 as Key a Component of the Coenzyme Q Synthesis Complex". Antioxidants 13, n.º 4 (21 de abril de 2024): 496. http://dx.doi.org/10.3390/antiox13040496.
Texto completo da fonteMa, Peilin, Raghuveer Mali, Li-Fan Zeng, Holly Martin, Baskar Ramdas, Yantao He, Emily Sims et al. "KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML". Blood 118, n.º 21 (18 de novembro de 2011): 868. http://dx.doi.org/10.1182/blood.v118.21.868.868.
Texto completo da fonteWang, Xingdong, Jie Pei, Pengjia Bao, Chunnian Liang, Min Chu, Shaoke Guo, Ping Yan e Xian Guo. "Identification of Yak’s TLR4 Alternative Spliceosomes and Bioinformatic Analysis of TLR4 Protein Structure and Function". Animals 11, n.º 1 (26 de dezembro de 2020): 32. http://dx.doi.org/10.3390/ani11010032.
Texto completo da fontePerduca, Massimiliano, Michele Bovi, Mattia Bertinelli, Edoardo Bertini, Laura Destefanis, Maria E. Carrizo, Stefano Capaldi e Hugo L. Monaco. "High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase". Acta Crystallographica Section D Biological Crystallography 70, n.º 8 (25 de julho de 2014): 2125–38. http://dx.doi.org/10.1107/s1399004714012462.
Texto completo da fonteZECHEL, David L., Shouming HE, Claude DUPONT e Stephen G. WITHERS. "Identification of Glu-120 as the catalytic nucleophile in Streptomyces lividans endoglucanase CelB". Biochemical Journal 336, n.º 1 (15 de novembro de 1998): 139–45. http://dx.doi.org/10.1042/bj3360139.
Texto completo da fonteCooper, William C., Yi Jin e Trevor M. Penning. "Elucidation of a Complete Kinetic Mechanism for a Mammalian Hydroxysteroid Dehydrogenase (HSD) and Identification of All Enzyme Forms on the Reaction Coordinate". Journal of Biological Chemistry 282, n.º 46 (11 de setembro de 2007): 33484–93. http://dx.doi.org/10.1074/jbc.m703414200.
Texto completo da fontePurushotham, K. R., Y. Nakagawa, M. G. Humphreys-Beher, N. Maeda e C. A. Schneyer. "Rat Parotid Gland Acinar Cell Proliferation: Signal Transduction at the Plasma Membrane". Critical Reviews in Oral Biology & Medicine 4, n.º 3 (abril de 1993): 537–43. http://dx.doi.org/10.1177/10454411930040034001.
Texto completo da fonteDiaz-Bárcena, Alba, Luis Fernandez-Pacios e Patricia Giraldo. "Structural Characterization and Molecular Dynamics Study of the REPI Fusion Protein from Papaver somniferum L." Biomolecules 14, n.º 1 (19 de dezembro de 2023): 2. http://dx.doi.org/10.3390/biom14010002.
Texto completo da fonteGómez-Melero, Sara, Fé Isabel García-Maceira, Tania García-Maceira, Verónica Luna-Guerrero, Gracia Montero-Peñalvo, Javier Caballero-Villarraso, Isaac Túnez e Elier Paz-Rojas. "Development of a High-Throughput Calcium Mobilization Assay for CCR6 Receptor Coupled to Hydrolase Activity Readout". Biomedicines 10, n.º 2 (10 de fevereiro de 2022): 422. http://dx.doi.org/10.3390/biomedicines10020422.
Texto completo da fonteChao, Nan, Wen-Ting Jiang, Xue-Chun Wang, Xiang-Ning Jiang e Ying Gai. "Novel motif is capable of determining CCR and CCR-like proteins based on the divergence of CCRs in plants". Tree Physiology 39, n.º 12 (21 de novembro de 2019): 2019–26. http://dx.doi.org/10.1093/treephys/tpz098.
Texto completo da fonteZhao, Yi, Eliud Morales Morales Dávila, Xue Li, Beiyu Tang, Ariana I. Rabinowitsch, Jose Manuel Perez-Aguilar e Carl P. Blobel. "Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17". International Journal of Molecular Sciences 23, n.º 21 (24 de outubro de 2022): 12796. http://dx.doi.org/10.3390/ijms232112796.
Texto completo da fonteAlves, Krisnna M. A., Fábio José Bonfim Cardoso, Kathia M. Honorio e Fábio A. de Molfetta. "Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana". Medicinal Chemistry 16, n.º 6 (7 de setembro de 2020): 784–95. http://dx.doi.org/10.2174/1573406415666190712111139.
Texto completo da fonteGao, Dan, Mohamed Madi, Cherlyn Ding, Matthew Fok, Thomas Steele, Christopher Ford, Leif Hunter e Chen Bing. "Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes". American Journal of Physiology-Endocrinology and Metabolism 307, n.º 3 (1 de agosto de 2014): E289—E304. http://dx.doi.org/10.1152/ajpendo.00430.2013.
Texto completo da fonteTakacs, Gregory, Yujia Zhou, David J. King, Amy Meacham, Loguinov Alex, Abderrahmane Tagmount, Amin Sobh, Max Russo, Chris D. Vulpe e Christopher R. Cogle. "CRISPR Dropout Screens Identify DHODH,PIK3C3, and Crkl as Potential Therapeutic Targets in Acute Myeloid Leukemia". Blood 134, Supplement_1 (13 de novembro de 2019): 1452. http://dx.doi.org/10.1182/blood-2019-128180.
Texto completo da fonteRieger, Leonie, Kilian Irlinger, Franziska Fuechsl, Nicolas Barbian, Marlene Tietje, Melanie Faber, Tobias Schulze et al. "Regulation of BCMA By the Ubiquitin Proteasome System Enables Optimization of BCMA-Targeting Therapies in Multiple Myeloma". Blood 142, Supplement 1 (28 de novembro de 2023): 3310. http://dx.doi.org/10.1182/blood-2023-187349.
Texto completo da fonteMou, Peipei, Zhao Zeng, Lijie Ren, Qiang Li, Kenneth M. Wannemacher, Xi Mo, Lawrence F. Brass e Li Zhu. "Identification of a Region within the Cytoplasmic Domain of Sema4D That Binds Calmodulin and Regulates Shedding of the Sema4D Exodomain in Platelets",. Blood 118, n.º 21 (18 de novembro de 2011): 3249. http://dx.doi.org/10.1182/blood.v118.21.3249.3249.
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