Literatura científica selecionada sobre o tema "Leukemia initiation and transformation"
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Artigos de revistas sobre o assunto "Leukemia initiation and transformation"
He, Jin, Anh Tram Nguyen e Yi Zhang. "KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia". Blood 117, n.º 14 (7 de abril de 2011): 3869–80. http://dx.doi.org/10.1182/blood-2010-10-312736.
Texto completo da fonteHurtz, Christian, Katerina Hatzi, Leandro Cerchietti, Melanie Braig, Eugene Park, Yong-mi Kim, Sebastian Herzog et al. "BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia". Journal of Experimental Medicine 208, n.º 11 (12 de setembro de 2011): 2163–74. http://dx.doi.org/10.1084/jem.20110304.
Texto completo da fonteMendoza-Castrejon, Jonny, Emily B. Casey, Riddhi M. Patel, Elisabeth Denby e Jeffrey Magee. "Fetal MLL-ENL Initiation Induces Developmental Stage-Specific Programs That Restrict Transformation and Depend on MLL3". Blood 142, Supplement 1 (28 de novembro de 2023): 950. http://dx.doi.org/10.1182/blood-2023-178865.
Texto completo da fonteUgale, Amol Sanjay, Gudmundur Logi Norddahl, Martin Wahlestedt, Petter Säwén, Pekka Jaako, Cornelis J. H. Pronk, Shamit Soneji, Jorg Cammenga e David Bryder. "Hematopoietic Stem Cells Are Intrinsically Protected Against MLL-ENL Mediated Transformation". Blood 124, n.º 21 (6 de dezembro de 2014): 839. http://dx.doi.org/10.1182/blood.v124.21.839.839.
Texto completo da fonteOkeyo-Owuor, Theresa, Yanan Li, Riddhi M. Patel, Wei Yang, Emily B. Casey, Andrew S. Cluster, Shaina N. Porter, David Bryder e Jeffrey A. Magee. "The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development". Blood Advances 3, n.º 15 (12 de agosto de 2019): 2388–99. http://dx.doi.org/10.1182/bloodadvances.2019000554.
Texto completo da fonteBunworasate, Udomsak, Hilal Arnouk, Hans Minderman, Kieran L. O'Loughlin, Sheila N. J. Sait, Maurice Barcos, Carleton C. Stewart e Maria R. Baer. "Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia". Blood 98, n.º 12 (1 de dezembro de 2001): 3492–94. http://dx.doi.org/10.1182/blood.v98.12.3492.
Texto completo da fonteTsuruta-Kishino, Takako, Keisuke Kataoka, Hiroshi Kobayashi, Junji Koya, Kensuke Narukawa, Tomohiko Sato e Mineo Kurokawa. "Loss Of p53 Induces Leukemic Transformation In a Murine Model Of JAK2V617F-Induced Polycythemia Vera". Blood 122, n.º 21 (15 de novembro de 2013): 269. http://dx.doi.org/10.1182/blood.v122.21.269.269.
Texto completo da fonteWagenblast, Elvin, Joana Araújo, Olga I. Gan, Sarah K. Cutting, Alex Murison, Jessica L. McLeod, Gabriela Krivdova et al. "A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression". Blood 136, Supplement 1 (5 de novembro de 2020): 11–12. http://dx.doi.org/10.1182/blood-2020-135867.
Texto completo da fonteWang, Pin-Yi, Fay Young, Chun-Yu Chen, Brett M. Stevens, Sarah J. Neering, Randall M. Rossi, Timothy Bushnell et al. "The biologic properties of leukemias arising from BCR/ABL-mediated transformation vary as a function of developmental origin and activity of the p19ARF gene". Blood 112, n.º 10 (15 de novembro de 2008): 4184–92. http://dx.doi.org/10.1182/blood-2008-02-142190.
Texto completo da fonteSharma, Ritul, Chunfen Zhang e Aru Narendran. "The Small-Molecule E26-Transformation-Specific Inhibitor TK216 Attenuates the Oncogenic Properties of Pediatric Leukemia". Genes 14, n.º 10 (8 de outubro de 2023): 1916. http://dx.doi.org/10.3390/genes14101916.
Texto completo da fonteTeses / dissertações sobre o assunto "Leukemia initiation and transformation"
Bayet, Manon. "Modélisation de la leucémie aiguë lymphoblastique B induite par la mutation PAX5 P80R". Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://www.theses.fr/2024TLSES005.
Texto completo da fonteThe team is interested in alterations in transcription factors involved in acute leukemia, including PAX5, which is essential for B-cell development. This is why the PAX5-ELN transgenic mouse model was generated, which expresses the oncogenic fusion protein during B-cell development, and recapitulates the multi-step process of B-ALL (Jamrog L et al., PNAS, 2018). I was involved in identifying the cells at the origin of-B-ALL and characterizing their functional and molecular properties. Our work indicates that at pre-leukemic stage, PAX5-ELN induces the emergence of an aberrant population of B-progenitors with an abnormal self-renewal property. This population is enriched in quiescent cells resistant to chemotherapeutic agents, activating a molecular stem cell program and supporting long-term leukemic initiation. This work is the subject of a recent publication signed by myself as second author (Fregona V, Bayet M et al., J Exp Med, in press). In parallel, my thesis focused on modeling the initiation and leukemic transformation induced by the PAX5P80R mutation, a frequent initiating alteration in patients. I used fetal liver cells derived from Pax5-/- mouse embryos to select lymphoid progenitors not committed to the B lineage. After transduction with CTL, PAX5 Wt or PAX5P80R retroviruses, I showed that PAX5P80R does not restore efficiently definitive commitment of cells to the B lineage. Transplantation experiments have shown that PAX5P80R induces aberrant engraftment potential followed by the development of B-ALL. This leukemic transformation is associated with the selection of clones carrying additional mutations affecting the JAK/STAT signaling pathway. Our analyses identified Hif2 as a potential candidate for leukemogenesis. Finally, pharmalogical screening of Hif inhibitors revealed Acriflavine as an interesting compound targeting leukemic cells. Thus, the modeling of B-ALL by the PAX5P80R mutation provides the team with a new tool to mimic the multi-step process of B-ALL, and to decipher the biological mechanisms by which the mutation leads to tumor transformation. This work is the subject of a manuscript in preparation which I have signed as first author (Bayet M, Fregona V, et al., in preparation). The PAX5-ELN and PAX5P80R models not only make it possible to study the various stages of B leukemogeneis, but also serve as a basis for the development of small molecule screening on primary cells. I therefore set up a miniaturized and robust protocol by FACS to screen chemical compounds targeting pre-leukemic cells. Our multiparametric approach enables us to simultaneously assess the effect of compounds on pre-leukeic cells and normal B subpopulations. I screened a bank of 1040 synthetic and natural compounds (essential chemical library) reflecting the chemical diversity of the French national chemical library. This screening, combined with dose-response counter-screening, enabled me to identify 5 molecules of interest. Overall, my work demonstrates the feasibility of small-molecule screening on a population enriched in leukemia-initiating cells, taking into account the intrinsic complexity of primary B-cells. Finally, I edited and published a review in the journal Cancers outlining the concepts of tumor heterogeneity in patients' leukemic cells, the utility of transgenic mouse models to explore the leukemia initiating cell compartment, and current efforts to discover new targeted therapies (Fregona V*, Bayet M* et al, Cancers (Basel), 2021), wich I co-authored
Kline, Dana L. "Contextualizing Transformation| Initiation Dreams of Depth Psychotherapists-in-Training". Thesis, Pacifica Graduate Institute, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1692045.
Texto completo da fonteThis thesis explores how the depth psychotherapist can experience a sacred passage of initiation in the context of archetypal dreams. It examines the intersections of meaning making in alchemical and mythological dream imagery and the numinous experience of initiation. It explores C. G. Jung’s individuation process and whether identifying dream images as archetypal wounds can deepen the psychotherapist–client therapeutic relationship. Using hermeneutic and heuristic methodology, this research uses a comparative analytical lens and the author’s personal process of tracking two archetypal dreams that coincide with the author’s answer to the soul’s calling to depth psychology and the first phase of seeing psychotherapy clients in graduate training. Honoring the unconscious as a map for psychological complexes, emotional states, unexpressed narratives, and symbols of both the personal and collective, the author expands upon an ancient way of honoring the death and rebirth of an individual in a transformative state of growth.
Mishra, Shrikant. "Mechanism of TNF-α cytotoxicity in a leukemia virus transformation model". Diss., Virginia Tech, 1991. http://hdl.handle.net/10919/39214.
Texto completo da fonteMishra, Shrikant. "Mechanism of TNF-[alpha] cytotoxicity in a leukemia virus transformation model /". This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-08232007-112933/.
Texto completo da fonteVoronin, Yegor A. "Investigation of initiation of reverse transcription in retroviruses using vectors with two primer-binding sites". Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=3136.
Texto completo da fonteJenkins, Catherine Elfi Sarah. "Mechanisms of acute leukemia disease initiation and maintenance through manipulation of IGF1R and RUNX family members". Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61331.
Texto completo da fonteMedicine, Faculty of
Graduate
Chakraborty, Pritam. "WAVELET TRANSFORMATION BASED MULTI-TIME SCALE METHOD FOR FATIGUE CRACK INITIATION IN POLYCRYSTALLINE ALLOYS". The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1325091714.
Texto completo da fonteSeok, Daniel, e Grant Skrepnek. "Inpatient Charges and Mortality of Richter’s Transformation of Chronic Lymphocytic Leukemia in the United States". The University of Arizona, 2012. http://hdl.handle.net/10150/614535.
Texto completo da fonteSpecific Aims: The objectives of this study were to determine the financial impact and mortality of CLL and Richter’s transformation in CLL in the inpatient setting in the payer’s perspective, the common diagnoses at discharge for patients with CLL, and to compare demographics, hospital characteristics, and co-morbidities for CLL cases versus Richter’s only cases. Methods: This study was a retrospective cohort of inpatient hospital charges and mortality of CLL patients and CLL patients with Richter’s transformation in the United States in the perspective of the payer. Using weighted statistical methods, results of this investigation yielded nationally-representative findings. The hospital charges were analyzed with a gamma regression with log link, and mortality was analyzed with a generalized linear regression. Main Results: There were total of 391,287 cases and 7% (27,259) were Richter’s cases. The overall hospital charges for CLL and CLL patients with Richter’s transformation from 2005 to 2009 were $38,735 (±58859) per case and $53,118 (±77993) per case, respectively. The mortality was 6.3% (24,520 deaths) overall and 9.1% mortality (2,485 deaths) for Richter’s transformation patients. The significant predictors (p < 0.05) that were associated with an increase the hospital charges for Richter’s patients was sepsis while sepsis and weight loss were associated with an increase in mortality. Conclusions This study adds to the few studies published to show the impact of CLL and Richter’s. However, due to the limitation on pharmacotherapies, it was not possible to determine therapeutic cost drivers for these cases. Future studies are warranted to determine the cost of therapies associated to the different stages of CLL.
Apichella, Michael. "Interstate '69 : the separation, initiation, and transformation of the fatherless hero in myth and literature". Thesis, Aberystwyth University, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742419.
Texto completo da fonteKennah, Erin. "Identification of differentially expressed genes in AHI-1-mediated leukemic transformation in cutaneous t-cell lymphoma". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/962.
Texto completo da fonteLivros sobre o assunto "Leukemia initiation and transformation"
Kate, Burns. Paths to transformation: From initiation to liberation. Asheville, North Carolina: Chiron Publications, 2014.
Encontre o texto completo da fonte1927-, Freireich Emil J., e Kantarjian Hagop 1952-, eds. Leukemia: Advances in research and treatment. Boston: Kluwer Academic Publishers, 1993.
Encontre o texto completo da fonteSteward, R. J. The Underworld Initiation: A journey towrds psychic transformation. Wellingborough: Aquarian, 1985.
Encontre o texto completo da fonteThe underworld initiation: A journey towards psychic transformation. Wellingborough: Aquarian, 1985.
Encontre o texto completo da fonteStewart, R. J. The underworld initiation: A journey towards psychic transformation. Lake Toxaway, NC: Mercury Pub., 1998.
Encontre o texto completo da fonteBeyerl, Paul. A Wiccan bardo, revisited: Initiation and self-transformation. 2a ed. Kirkland, WA: Hermit's Grove, 1999.
Encontre o texto completo da fonteThe underworld initiation: A journey towards psychic transformation. Lake Toxaway, NC: Mercury Pub., 1999.
Encontre o texto completo da fonteThe chromosomes in human cancer and leukemia. 2a ed. New York: Elsevier, 1990.
Encontre o texto completo da fonteL, Moore Robert. The archetype of initiation: Sacred space, ritual process, and personal transformation : lectures and essays. [Philadelphia]: Xlibris Corp., 2001.
Encontre o texto completo da fonteNougier, Paul. Déformation des roches et transformation de leurs minéraux: Initiation à la tectonique. Paris: Ellipses-Marketing, 2000.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Leukemia initiation and transformation"
Zeisig, Bernd B., e Chi Wai Eric So. "Retroviral/Lentiviral Transduction and Transformation Assay". In Leukemia, 207–29. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-418-6_10.
Texto completo da fonteSo, Chi Wai Eric. "An Overview: From Discovery of Candidate Mutations to Disease Modeling and Transformation Mechanisms of Acute Leukemia". In Leukemia, 1–5. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-418-6_1.
Texto completo da fonteSarin, Prem S. "HTLV in Adult T Cell Leukemia and Acquired Immune Deficiency Syndrome". In Cell Transformation, 185–208. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-5009-5_12.
Texto completo da fonteSchetelig, Johannes, e Peter Dreger. "Chronic Lymphocytic Leukemia". In The EBMT Handbook, 771–75. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-44080-9_85.
Texto completo da fonteDhekney, Sadanand A., Zhijian T. Li, Manjul Dutt e Dennis J. Gray. "Initiation and Transformation of Grapevine Embryogenic Cultures". In Methods in Molecular Biology, 215–25. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-558-9_18.
Texto completo da fontePawelski, S., L. Konopka, K. Szczepanik e H. Zdziechowska. "Therapy of Blastic Transformation of Chronic Myeloid Leukemia". In Leukemias, 249–55. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77083-8_45.
Texto completo da fonteYasunaga, Junichiro, e Kuan-Teh Jeang. "Human T-Cell Leukemia Virus Type 1, Cellular Transformation, and Adult T-Cell Leukemia". In National Institute of Allergy and Infectious Diseases, NIH, 41–49. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-512-5_5.
Texto completo da fonteTaylor, C., A. Jalava e S. Mai. "c-Myc Dependent Initiation of Genomic Instability During Neoplastic Transformation". In Current Topics in Microbiology and Immunology, 201–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60801-8_20.
Texto completo da fonteKolch, W., R. H. Bassin e U. R. Rapp. "Raf Function Is Required for Proliferation of NIH|3T3 Cells and Transformation by Nonnuclear Oncogenes". In Modern Trends in Human Leukemia IX, 208–12. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76829-3_33.
Texto completo da fonteChi, Ya-Hui, e Kuan-Teh Jeang. "Chromosomal Instability and Human T Cell Leukemia Virus 1 Transformation". In Translational Research in Biomedicine, 228–38. Basel: KARGER, 2008. http://dx.doi.org/10.1159/000141523.
Texto completo da fonteTrabalhos de conferências sobre o assunto "Leukemia initiation and transformation"
Minami, Yosuke, Nobuaki Fukushima, Anil Sadarangani, Hironobu Minami, Catriona Jamieson e Tomoki Naoe. "Abstract 1884: Treatment with Hedgehog inhibitor PF-913 attenuates leukemia-initiation potential in acute myeloid leukemia cells". In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1884.
Texto completo da fonteBhattacharjee, Romel, e Lalit Mohan Saini. "Detection of Acute Lymphoblastic Leukemia using watershed transformation technique". In 2015 International Conference on Signal Processing, Computing and Control (ISPCC). IEEE, 2015. http://dx.doi.org/10.1109/ispcc.2015.7375060.
Texto completo da fonteAifantis, Iannis. "Abstract IA24: Regulation of acute leukemia initiation and progression by long noncoding RNAs." In Abstracts: AACR Special Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies; September 20-23, 2014; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.hemmal14-ia24.
Texto completo da fonteWan, Minjie, Guohua Gu, Qian Chen, Weixian Qian e Pengcheng Wang. "Fast randomized Hough transformation track initiation algorithm based on multi-scale clustering". In Applied Optics and Photonics China (AOPC2015), editado por Chunhua Shen, Weiping Yang e Honghai Liu. SPIE, 2015. http://dx.doi.org/10.1117/12.2197916.
Texto completo da fonteChen, Rong, Mingzhao Zhu, Rajan R. Chaudhari, Omar Robles, Yuling Chen, Wesley Skillern, Qun Qin et al. "Abstract 1854: Novel pateamine analogs to target the translation initiation factor eIF4A in chronic lymphocytic leukemia". In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-1854.
Texto completo da fonteChen, Rong, Mingzhao Zhu, Rajan R. Chaudhari, Omar Robles, Yuling Chen, Wesley Skillern, Qun Qin et al. "Abstract 1854: Novel pateamine analogs to target the translation initiation factor eIF4A in chronic lymphocytic leukemia". In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-1854.
Texto completo da fonteShakir, A., S. Nusrat e A. Keruakous. "Ruxolitinib Discontinuation Syndrome in a Patient with Myelofibrosis to Acute Myeloid Leukemia Transformation". In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1479.
Texto completo da fonteFrolov, Nikita, Elena Pitsik e Nikolaj Schukovskii. "Transformation of the Theta-band Functional Connectivity During Motor Initiation Under Healthy Aging". In 2020 4th Scientific School on Dynamics of Complex Networks and their Application in Intellectual Robotics (DCNAIR). IEEE, 2020. http://dx.doi.org/10.1109/dcnair50402.2020.9216901.
Texto completo da fonteOka, Takashi, Lamia Abd Al-Kader, Hiaki Sato, Kana Washio, Yoko Shinnou, Katsuyoshi Takata, Ichiro Murakami, Atae Utsunomiya e Tadashi Yoshino. "Abstract 3132: Dynamic changes of epigenetic abnormalities during initiation and progression of adult T-cell leukemia/lymphoma (ATLL)". In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3132.
Texto completo da fonteIchim, Christine V., Alden Chesney, Marciano Reis, Norman N. Iscove e Richard A. Wells. "Abstract 1588: NR2F6, a novel regulator of stem cell maintenance, is necessary and sufficient for initiation of acute leukemia". In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1588.
Texto completo da fonteRelatórios de organizações sobre o assunto "Leukemia initiation and transformation"
Halene, Stephanie. Assessing the Mechanisms of MDS and its Transformation to Leukemia in a Novel Humanized Mouse. Fort Belvoir, VA: Defense Technical Information Center, setembro de 2014. http://dx.doi.org/10.21236/ada610689.
Texto completo da fonteJiang, Zhiping, Ao Zhang, Shuxing Wang, Quanlei Ren e Yizhu Wang. Prognostic value of ASXL1 mutations in patients with myelodysplastic syndromes and acute myeloid leukemia: A meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, abril de 2022. http://dx.doi.org/10.37766/inplasy2022.4.0013.
Texto completo da fonteElroy-Stein, Orna, e Dmitry Belostotsky. Mechanism of Internal Initiation of Translation in Plants. United States Department of Agriculture, dezembro de 2010. http://dx.doi.org/10.32747/2010.7696518.bard.
Texto completo da fonteMeir, Shimon, Michael S. Reid, Cai-Zhong Jiang, Amnon Lers e Sonia Philosoph-Hadas. Molecular Studies of Postharvest Leaf and Flower Senescence. United States Department of Agriculture, janeiro de 2011. http://dx.doi.org/10.32747/2011.7592657.bard.
Texto completo da fonte