Literatura científica selecionada sobre o tema "Leptospirosis disease"
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Artigos de revistas sobre o assunto "Leptospirosis disease"
Charishma Devi, T. V. L., B. Mounika, SK Sharmila, Satheesh S. Gottipati e P. Srinivas Babu. "A REVIEW ON EPIDEMIOLOGY, PATHOGENESIS AND TREATMENT OF LEPTOSPIROSIS". International Journal of Advanced Research 9, n.º 09 (30 de setembro de 2021): 498–504. http://dx.doi.org/10.21474/ijar01/13439.
Texto completo da fonteChancharoenthana, Wiwat, Asada Leelahavanichkul, Marcus J. Schultz e Arjen M. Dondorp. "Going Micro in Leptospirosis Kidney Disease". Cells 11, n.º 4 (16 de fevereiro de 2022): 698. http://dx.doi.org/10.3390/cells11040698.
Texto completo da fonteYang, C. W., M. S. Wu e M. J. Pan. "Leptospirosis renal disease". Nephrology Dialysis Transplantation 16, suppl 5 (1 de julho de 2001): 73–77. http://dx.doi.org/10.1093/ndt/16.suppl_5.73.
Texto completo da fonteMulyani, Guntari Titik, Sri Hartati, Hastari Wuryastuty, Ida Tjahajati, Yuriadi Yuriadi, Irkham Widiyono, Yanuartono Yanuartono et al. "Identifikasi Serovar Penyebab Leptospirosis pada Anjing di Yogyakarta". Jurnal Sain Veteriner 37, n.º 2 (11 de dezembro de 2019): 227. http://dx.doi.org/10.22146/jsv.39201.
Texto completo da fonteP, Pati. "Leptospirosis One of the Risk Factor for Kidney Diseases". Open Access Journal of Urology & Nephrology 8, n.º 1 (13 de janeiro de 2023): 1–4. http://dx.doi.org/10.23880/oajun-16000223.
Texto completo da fonteKozishkurt, E., K. Talalaev, O. Melnik, O. Sovirda, E. Gerasimenko e L. Kostolonova. "Рredicting epizootic risks of leptospirosis". Journal of Education, Health and Sport 12, n.º 2 (28 de fevereiro de 2022): 351–59. http://dx.doi.org/10.12775/jehs.2022.12.02.036.
Texto completo da fonteBoertjes, Emma, Stefanie Hillebrand, Janneke Elisabeth Bins e Laurien Oswald. "Pulmonary haemorrhage in Weil’s disease". BMJ Case Reports 13, n.º 1 (janeiro de 2020): e227570. http://dx.doi.org/10.1136/bcr-2018-227570.
Texto completo da fonteVinetz, Joseph, Alyssa N. Chetrick, Katie E. Steimel, Carla E. Devillers, Jean-Louis Excler, Jerome H. Kim e Suneth Agampodi. "Getting leptospirosis onto the lists of neglected tropical diseases". Open Access Government 43, n.º 1 (8 de julho de 2024): 52–54. http://dx.doi.org/10.56367/oag-043-11310.
Texto completo da fonteLevett, Paul N. "Leptospirosis". Clinical Microbiology Reviews 14, n.º 2 (1 de abril de 2001): 296–326. http://dx.doi.org/10.1128/cmr.14.2.296-326.2001.
Texto completo da fonteRahayu, Ingrit Ridha. "PEMODELAN MATEMATIKA PENYEBARAN PENYAKIT LEPTOSPIROSIS DENGAN PENGARUH TREATMENT". Journal of Mathematics UNP 7, n.º 1 (30 de março de 2022): 28. http://dx.doi.org/10.24036/unpjomath.v7i1.10923.
Texto completo da fonteTeses / dissertações sobre o assunto "Leptospirosis disease"
Yan, Ke-Ting. "Aspects of immunity to Leptospira borgpetersenii serovar hardjo". Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387931.
Texto completo da fontedel, Valle-Mendoza Juana, Carlos Palomares-Reyes, Hugo Carrillo-Ng, Yordi Tarazona-Castro, Sungmin Kym, Miguel Angel Aguilar-Luis, Valle Luis J. Del et al. "Leptospirosis in febrile patients with suspected diagnosis of dengue fever". BioMed Central Ltd, 2021. http://hdl.handle.net/10757/657332.
Texto completo da fonteObjective: This study was carried out to determine the prevalence of leptospirosis among febrile patients with a suspicious clinical diagnosis of dengue fever in northern Peru. Results: A total of 276 serum samples from patients with acute febrile illness (AFI) and suspected diagnosis for dengue virus (DENV) were analyzed. We identified an etiological agent in 121 (47.5%) patients, DENV was detected in 30.4% of the cases, leptospirosis in 11.2% and co-infection by both pathogens was observed in 5.9% of the patients. In this study the most common clinical symptoms reported by the patients were: headache 89.1%, myalgias 86.9% and arthralgias 82.9%. No differences in symptomatology was observed among the different study groups.
National Research Foundation of Korea
Revisión por pares
Soares, Luciane Marieta. "O uso da talidomida como terapia adjuvante na leptospirose experimental". reponame:Repositório Institucional da FIOCRUZ, 2013. https://www.arca.fiocruz.br/handle/icict/7524.
Texto completo da fonteMade available in DSpace on 2014-04-22T16:33:21Z (GMT). No. of bitstreams: 1 Luciane Marieta Soares O uso da talidomida...2013.pdf: 1032465 bytes, checksum: 705c1f8374aee3a4f8a1b0f537cd33f6 (MD5) Previous issue date: 2013
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
A leptospirose é uma zoonose de importância global, causada por leptospiras patogênicas. Seu tratamento é limitado quando iniciado após quatro dias do surgimento de sintomas, portanto, novas terapias adjuvantes são necessárias. Objetivo. Testar a droga imunomoduladora talidomida como terapia adjuvante à ampicilina no modelo de tratamento tardio da leptospirose experimental em hamsters. Métodos. 60 hamsters foram infectados via intraperitoneal por Leptospirainterrogans cepa L1-130, e foram separados em grupos: nenhum tratamento (NONE), talidomida (TAL), ampicilina (AMP) e ambos (AMP-TAL). A talidomida foi administrada via sonda orogástrica na dosagem de 50 mg/Kg diluída em óleo de linhaça (2ml/Kg) por três dias. Já a ampicilina por via intramuscular: 100mg/Kg/bid por seis dias. Foram realizados dois desenhos experimentais. Experimento 1: o tratamento foi iniciado 48h após o início dos sinais clínicos da doença. Experimento 2: o tratamento foi iniciado imediatamente após a detecção do primeiro óbito entre os animais infectados. Resultados. Experimento1: todos os hamsters dos grupos AMP e AMP-TAL sobreviveram (n=8) enquanto todos os animais dos grupos NONE (n=6) e TAL (n=8) morreram. Os hamsters dos grupos AMP e AMP-TAL não mostraram lesões renais, pulmonares ou hepáticas. Baixa carga de leptospiras foi detectada nos órgãos alvo. Experimento 2: o desfecho letal foi observado em 6/6 hamsters no grupo NONE, 8/8 do grupo TAL, 6/8 do AMP e 6/8 do AMP-TAL. A talidomida usada como adjuvante não prolongou a sobrevida dos animais tratados com ampicilina. No entanto, o grupo TAL apresentou sobrevida mais longa que o grupo que não recebeu tratamento algum. Os animais tratados apresentaram maior frequência de destrabeculação de hepatócitos. Conclusão: Esse estudo abre novas perspectivas no desenvolvimento de um tratamento tardio na leptospirose, contudo observou-se que a talidomida utilizada como terapia adjuvante não teve impacto na sobrevida de hamsters como modelo de início tardio de terapia antimicrobiana.
Leptospirosis is a zoonosis of global importance, caused by pathogenic leptospira. His treatment is limited when started after four days of onset of symptoms, increasing the risk of morbidity and mortality, so new adjuvant therapies are needed.Objectives.To test the immunomodulatory drug, thalidomide, as an adjuvant therapy to antibiotics in experimental leptospirosis. Methods. Hamsters were infected by Leptospirainterrogans strain L1-130, and groups were assigned based on no treatment (NONE), thalidomide only (TAL), ampicillin only (AMP) or both (AMP-TAL). Thalidomide was administered via a gastric tube: 50 mg/kg in linseed oil and 2 ml/kg for three days. Ampicillin was administered intramuscularly at the rate of 100 mg/kg/bid for six days. Treatment was started two days after the onset of symptoms (experiment 1) and immediately after detection of the first death (experiment 2). Results. Experiment 1: all hamsters from the groups AMP and AMP-TAL survived (n=8), while all hamsters from groups NONE (n=6) and TAL (n=8) died. The AMP and the AMP-TAL groups showed no renal, lung or liver pathology and absent or very low leptospiral burden in target organs. Experiment 2: lethal outcome was observed in 6/6 hamsters in the NONE group, 8/8 in the TAL group, and 6/8 in the AMP group and the AMP-TAL group. Thalidomide showed no survival benefit when compared to hamsters treated with ampicillin alone. The TAL group, however, had a longer interval between infection and death when compared to the NONE group. Treated animals had a higher frequency of liver plate disarray. The TAL, AMP and AMP-TAL groups had very low tissue leptospiral counts. Conclusion: This study may open new perspectives to assist the development of a delayed treatment in leptospirosis, however it was observed that thalidomide used as adjuvant therapy had no impact on the survival of hamsters as late onset of antimicrobial therapy model.
Santos, Adriana Maria Amurete Roque dos. "Leptospirose canina : estudo retrospetivo sobre a relação entre as alterações hematológicas, achados ecográficos e desfecho clínico". Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2021. http://hdl.handle.net/10400.5/21233.
Texto completo da fonteO estudo retrospetivo desenvolvido teve como objetivo caraterizar uma amostra de canídeos infetados com Leptospira spp., comparando os resultados obtidos com os descritos pela bibliografia disponível e, ainda, verificar se existem associações entre as alterações he matológicas, os achados ecográficos e o desfecho clínico dos casos. A amostra do presente estudo é constituída por 17 cães diagnosticados com leptospi rose no Hospital Veterinário do Atlântico durante um período de quatro anos. As alterações analíticas mais frequentemente observadas na amostra incluem as con centrações elevadas de ureia (n=17), creatinina (n=17), FAS (n=14) e ALT (n=9), bem como a presença de leucocitose (n=11), neutrofilia (n=10) e trombocitopenia (n=10). Todos os animais apresentaram alterações ao exame ecográfico, sendo as mais fre quentes o aumento da ecogenecidade do córtex renal (n=10), renomegalia (n=8) e hepato megalia (n=8). Durante a hospitalização quase metade dos animais desenvolveram um quadro de infeção respiratória (n=8), verificando-se que a principal causa de morte dos animais deste estudo foi o desenvolvimento de hemorragia pulmonar (n=5). É possível concluir que os resultados obtidos neste estudo apresentam uma elevada concordância com os resultados descritos por outros autores, porém não se verificou a exis tência de correlações entre as alterações analíticas, achados ecográficos e o desfecho clínico dos casos.
ABSTRACT - Canine Leptospirosis: a retrospective study on the relation between haemato logical alterations, ultrasonography findings and clinical outcome - The aim of this study is to characterize, retrospectively, the data of dogs diagnosed with Leptospira spp. and compare the results with the current literature. Furthermore, to com pare the haematological alterations, ultrasonography findings and clinical outcomes of the dif ferent cases. The sample group consisted of 17 dogs diagnosed with leptospirosis at the Hospital Veterinário do Atlântico in the last four years. High concentrations of urea (n=17), creatinine (n=17), ALP (n=14) and ALT (n=9) were the most common laboratorial findings in the sample group, as well as leucocytosis (n=11), neutrophilia (n=10) and thrombocytopenia (n=10). Ultrasonography abnormalities were found in all the dogs, namely an increase in the echogenicity of the renal cortex (n=10), renomegaly (n=8) and hepatomegaly (n=8). During hospitalization, nearly half of the sample group developed respiratory symp toms/infection (n=8), which lead to the main cause of death, pulmonary haemorrhage (n=5). In conclusion, the results from this study are in concordance with results obtained from previous studies. On the other hand, no correlation was found between the haematological alterations, ultrasonography findings and clinical outcomes of the cases.
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Gallego-Beltran, Juan Fernando. "Leptospirosis in Columbian dairy cattle : microbiological, serological, molecular and epidemiological aspects of the disease". Thesis, Royal Veterinary College (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272308.
Texto completo da fonteМоскалюк, В. Д., М. О. Андрущак e І. В. Баланюк. "Клініко-епідеміологічна характеристика перебігу лептоспірозу у хворих на Буковині". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45570.
Texto completo da fonteГоляр, О. І., e Д. М. Шпарик. "Епідеміологічні особливості лептоспірозу в Україні". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45402.
Texto completo da fonteBiscornet, Leon. "Leptospirosis in the Seychelles : geographic, molecular and epidemiological investigations of a zoonotic disease in a tropical insular environment". Thesis, La Réunion, 2020. http://www.theses.fr/2020LARE0013.
Texto completo da fonteLeptospirosis is an emerging neglected disease representing a heavy burden in the tropics, especially in tropical islands such as Seychelles, which record among the highest human incidence worldwide. This thesis aims at exploring the eco-epidemiology of leptospirosis in Seychelles by (i) using rats as markers of environmental exposure to Leptospira infection, (ii) describing the molecular epidemiology of the disease in humans and animals in a One Health framework, and (iii) identifying occupational and behavioural risk factors while comparing the current situation to that described 25 years ago. The combination of fine spatial distribution, molecular and clinical epidemiology complement each other in providing a comprehensive picture of the continuum involving reservoirs and human hosts within a shared environment.Habitat fragmentation and proximity to nutritional sources are found good predictors of Leptospira-laden Rattus spp. Geospatial analyses determined a selection of other important variable factors that are strongly correlated with Leptospira infection in Rattus spp., including altitude or distance to surface water (negative correlation), urbanization and heavy rainfall (positive correlation). Results of these analyses can guide policy makers and especially urban planners to best implement landscape structures for conservation or pest control goals leading to reduced exposure of humans to rat-borne diseases.Rattus norvegicus is found significantly more infected than Rattus rattus. Therefore, increased infection in urbanized/fragmented habitats may result at least in part from Rattus spp distribution, as R. norvegicus is mostly found in urban areas. Most importantly, genotyping of Leptospira in human acute cases and rats suggests that these rodents are involved in only a third of human acute infections, while most human cases originate from yet to be identified reservoir(s).An annual incidence of 54.6 (95% CI 40.7-71.8) per 100,000 confirms the major medical and public health importance of the disease in the country. The disease affects mainly men (96%) and displays a case fatality rate of 11.2%, mostly associated with severe forms (acute renal failure, hepatic failure and pulmonary haemorrhage). Farming and gardening related activities, proximity to cattle and cats, thrombocytopaenia, leukocytosis, elevated bilirubin and high values for renal function tests are predictors of leptospirosis. The geographical distribution of human cases poorly overlaps districts of high prevalence in rats in keeping with a restricted role of rats in human disease.The comparison of figures reported herein and in previous studies published 25 years ago reveals changes in behaviour and exposure, and shows that the development of health care has lowered the case fatality despite still high disease incidence in the country. A low level of knowledge on leptospirosis is reported, urging the need for implementing health education campaigns. Altogether, the data presented in this thesis strongly supports the implementation of a research program aiming at discovering alternative reservoir(s) to provide a full understanding of the epidemiological situation, which will allow fine tuning preventive measures for an efficient control of a disease that is still recognised as the infectious disease causing the highest mortality in the country
Araújo, Wildo Navegantes de. "Aspectos epidemiológicos da leptospirose no Brasil, 2000 a 2009 e a avaliação do conhecimento e das atitudes sobre a doença em uma favela na cidade de Salvador, Bahia". reponame:Repositório Institucional da FIOCRUZ, 2010. https://www.arca.fiocruz.br/handle/icict/4324.
Texto completo da fonteMade available in DSpace on 2012-09-04T18:27:25Z (GMT). No. of bitstreams: 1 Wildo Navegantes Aspectos epidemiologicos da leptospirose....pdf: 1357912 bytes, checksum: 01380ce81c921e78d62f63cce2d77036 (MD5) Previous issue date: 2010
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
A leptospirose é a principal doença infecciosa zoonótica em áreas urbanas nos países em desenvolvimento, porém subnotificada. O conhecimento e as atitudes sobre a leptospirose é desconhecida nas comunidades brasileiras onde a doença é prevalente. Objetivos: 1) Descrever os casos notificados de leptospirose, fatores de risco para óbito, influência das chuvas em cidades metropolitanas e parte da carga da leptospirose no Brasil, 2000-2009. 2) Descrever o conhecimento e as atitudes sobre leptospirose dos moradores de uma favela na cidade de Salvador. Métodos:1) Foram descritos os casos notificados de leptospirose no Sistema Nacional de Vigilância de 2000 a 2009. Foi analisada a influência das chuvas e a ocorrência de casos de leptospirose em cinco metrópoles brasileiras. Foram calculadas as taxas de incidência, hospitalização, mortalidade e letalidade por leptospirose e foram avaliados os fatores de risco para óbito a partir das variáveis demográficas entre os casos confirmados. 2) Foi conduzido um estudo transversal sobre o conhecimento e atitudes sobre leptospirose na comunidade de Pau da Lima, Salvador – Bahia. Resultados: 1) A doença acomete populações vulneráveis socialmente que vivem em áreas urbanas. As taxas de incidência, hospitalização, mortalidade e letalidade foram 1,48, 1.04, 0,12 por 100.000 habitantes e 9%, respectivamente. A partir de 15 anos de idade (OR=1,88; IC95% 1,39-2,55), baixo nível educacional (OR=1,35; IC95% 1,17-1,56), viver em área urbana (OR=2,19; IC95% 1,80-2,69) foram detectados como fatores de risco para óbito entre os casos confirmados. As chuvas tiveram forte relação com a ocorrência de surtos sazonais da doença em cinco cidades metropolitanas. 2) 72,7% das pessoas sabem que a leptospirose é uma doença transmitida por ratos, 56,4% reconhecem que pegam a doença com o contato com urina de ratos, 17,8% referiram limpar esgotos ao redor da sua casa, 35,5% referiram usar luvas e 33,3% botas para se proteger. Conclusão: No Brasil, a doença acomete homens adultos, com baixa nível educacional que vivem em áreas urbanas, tais achados estão associados a óbitos. Muitos surtos sazonais ocorreram sob influência das chuvas nas cidades metropolitanas estudadas. Na comunidade de Pau da Lima, uma favela de Salvador, as pessoas conhecem a leptospirose e as principais atitudes detectadas estão relacionadas as contínuas exposições a água de chuvas e esgotos na comunidade. As conclusões deste trabalho apontam para a necessidade de estruturar serviços de saúde que antecedam as chuvas, e para obras de saneamento básico em regiões metropolitanas com maior incidência da doença. Recomendamos que sejam realizados outros estudos sobre o conhecimento em relação a leptospirose para entender os déficits de informação da população, assim como instruí-los para organizadamente cobrarem soluções como obras de saneamento básico que minimizem o impacto da leptospirose na população.
The leptospirosis is major zoonotic infectious disease in urban areas in the developing countries. However, the leptospirosis is underreported in the world. The knowledge and attitudes about leptospirosis of the communities which suffer due the leptospirosis is unavailable. Objectives 1) To describe the leptospirosis cases reported, risk factors for death, influence of the rainfalls in metropolitan cities and, part of the burden caused by the leptospirosis in Brazil from 2000 through 2009. 2) To describe the knowledge and attitudes about leptospirosis in slum area in metropolitan city of the Brazil. Methods: 1) Were described the leptospirosis cases reported in the National Surveillance System from 2000 to 2009. Were analyzed the influence of the rainfalls in metropolitan cities, were analyzed frequency measures and, were identified risk factors for death. 2) Was conducted a cross-section study about the knowledge and attitudes about leptospirosis in the community of “Pau da Lima”, Salvador- Bahia. Results: 1) The disease attacks adult men in economically active age with low educational level living in urban areas. Incidence, hospitalization, mortality and lethality rates were 1.48, 1.04, 0.12 per 100.000 inhabitants, and 9% respectively. Being aged 15 or above (OR=1.88; IC 95% 1.39-2.55), having low educational level (OR=1.35; IC 95% 1.17-1.56), and living in urban areas (OR=2.19; IC 95% 1.80-2.69) have been detected as risk factors for death among the confirmed cases. Rains were strongly related to the occurrence to seasonal outbreaks of the disease in five metropolitan cities studied. 2) In an urban slum in Salvador, 72.7% of the individuals know that leptospirosis is a disease transmitted by rats, 56.4% recognized that the disease can be contracted by getting in contact with the urine of rats, 17.8% clean the sewers surrounding their houses, 35.5% wear gloves and 33.3% wear boots to protect them. Conclusion: In Brazil, the disease attacks adult men with low educational level living in urban areas, these covariates are associated to death. Many seasonal outbreaks occur in the studied metropolitan cities under the influence of rain. In a slum area in Salvador, people know leptospirosis and the main attitudes detected are related to continuous exposition of the community to rainfalls and sewers. Health policies geared to structuring health services prior to rains and the implementation of basic sanitation infrastructure to be requirements for minimizing the occurrence of leptospirosis in mega cities. We also recommend the conduction of studies on the knowledge and attitudes in order to understand population’s information deficit, as well as to instruct them to demand solutions such as the construction of basic sanitation infrastructure in an orderly manner.
JÃnior, Geraldo Bezerra da Silva. "ManifestaÃÃes clinicas,classificaÃÃo da lesÃo renal aguda e fatores de risco para Ãbito em pacientes com a forma grave de leptospirose". Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13163.
Texto completo da fonteIntroduÃÃo. A leptospirose à uma doenÃa endÃmica no Nordeste, sendo caracterizada por complicaÃÃes potencialmente fatais como a lesÃo renal aguda (LRA). O objetivo deste estudo foi avaliar as manifestaÃÃes clÃnicas, a classificaÃÃo da LRA e os fatores de risco para Ãbito em pacientes com a forma grave de leptospirose. MÃtodos. Foi realizado estudo retrospectivo em pacientes com a forma grave de leptospirose internados em hospitais terciÃrios na cidade de Fortaleza, nordeste do Brasil. Foram avaliadas as manifestaÃÃes clÃnicas, os exames laboratoriais na admissÃo e durante a internaÃÃo e o tratamento instituÃdo. LRA foi definida de acordo com as classificaÃÃes RIFLE e AKIN, sendo comparados os pacientes nas diferentes classes. Foram comparados os pacientes que usaram com aqueles que nÃo usaram penicilina, assim como os pacientes que sobreviveram com os que foram a Ãbito. AnÃlises univariada e multivariada foram usadas para a investigaÃÃo dos fatores de risco para Ãbito. A anÃlise estatÃstica foi feita pelo programa SPSS versÃo 10.0. Resultados. Foram incluÃdos 287 pacientes, com mÃdia de idade de 36,8Â15,6 anos, sendo 80,8% do sexo masculino. Os principais sinais e sintomas apresentados foram febre (96,2%), mialgia (90,6%), icterÃcia (85,7%), cefaleia (74,2%), vÃmitos (70,7%), desidrataÃÃo (54%) e calafrios (53,7%). LRA foi observada em 237 pacientes (82%) pelo critÃrio RIFLE e 242 (84%) pelo AKIN. A mortalidade geral foi de 13%. A mortalidade foi semelhante nos pacientes que usaram e que nÃo usaram penicilina (11,6% vs. 13,7%, p=0,60). Aumento da mortalidade foi observado de acordo com as piores classificaÃÃes: RIFLE-R (2%), RIFLE-I (8%) e RIFLE-F (23%), assim como AKIN 1 (2%), AKIN 2 (8%) e AKIN 3 (23%), p < 0,0001. Os pacientes com oligÃria tiveram maior mortalidade (20%), em comparaÃÃo com os pacientes sem oligÃria (5%), p=0,02. Os fatores de risco independentes para Ãbito foram: RIFLE-F (OR=10,5, IC 95%=1,3-80,8, p<0,001), AKIN 3 (OR=7,5, IC 95%=2,2-25,2 p<0,001) e necessidade de diÃlise (OR=3,5, IC 95%=1,1-11,01, p=0,01). ConclusÃes. A LRA à uma complicaÃÃo frequente na leptospirose, com mortalidade significativa. Houve associaÃÃo entre as classificaÃÃes RIFLE e AKIN com a mortalidade na leptospirose. Os fatores de risco independentes para Ãbito sÃo classificaÃÃo RIFLE-F, AKIN 3 e necessidade de diÃlise.
Introduction. Leptospirosis is en endemic disease in Northeast of Brazil, which is characterized by potential fatal complications such as acute kidney injury (AKI). The aim of this study was to evaluate the clinical manifestations, the AKI classification and the risk factors for death in patients with the severe form of leptospirosis. Methods. A retrospective study was conducted in patients with severe form of leptospirosis admitted to tertiary hospitals in Fortaleza city, Northeast of Brazil. The clinical manifestations, laboratory tests at admission and during hospital stay, as well as treatment, were evaluated. AKI was defined according to the RIFLE and AKIN classifications, and the patients in each category were compared. Patients who used and who did not use penicillin, as well as survivors and non-survivors, were compared. Univariate and multivariate analysis were performed to investigate the risk factors for death. Statistical analysis was done with SPSS program version 10.0. Results. A total of 287 patients were included, with a mean age of 36.8Â15.6 years, and 80.8% were male. The main signs and symptoms at admission were fever (96.2%), myalgia (90.6%), jaundice (85.7%), headache (74.2%), vomiting (70.7%), dehydration (54%) and chills (53.7%). AKI was observed in 237 patients (82%) according to the RIFLE criteria and 242 (84%) according to AKIN. General mortality was 13%. Mortality was similar in patients who used and who did not use penicillin (11.6% vs. 13.7%, p=0.60). An increase in mortality was observed according to the worst classifications of RIFLE and AKIN: RIFLE-R (2%), RIFLE-I (8%) e RIFLE-F (23%), AKIN 1 (2%), AKIN 2 (8%) e AKIN 3 (23%), p<0.0001. Patients with oliguria had a higher mortality (20%), when compared to those without oliguria (5%), p=0.02. Independent risk factors for death were: RIFLE-F (OR=10.5, 95% CI=1.3-80.8, p<0.001), AKIN 3 (OR=7.5, 95% CI=2.2-25.2 p<0.001) and need of dialysis (OR=3.5, 95% CI=1.1-11.01, p=0.01). Conclusions. AKI is a frequent complication in leptospirosis, with significant mortality. There was association between RIFLE and AKIN classifications with mortality. Independent risk factors for death were RIFLE-F, AKIN 3 and need of dialysis.
Livros sobre o assunto "Leptospirosis disease"
Ireland. Food Safety Advisory Committee. Leptospiral infections, Lyme disease, Babesiosis, Orf virus disease. Dublin: Stationery Office, 1992.
Encontre o texto completo da fonteLeonard, Nola. Leptospirosis in cattle: Infection and control. [Dublin]: Teagasc, 1997.
Encontre o texto completo da fonteLeonard, Nola. Leptospirosis in cattle: Infection and control. [Dublin]: Teagasc, 1991.
Encontre o texto completo da fonteBurdmann, Emmanuel A. Leptospirosis. Editado por Vivekanand Jha. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0191.
Texto completo da fonteSmith, Robert M., e Wendy J. Zochowski. Leptospirosis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0027.
Texto completo da fonteClement, Jan. Acute kidney injury and hantavirus disease. Editado por Norbert Lameire. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0242_update_001.
Texto completo da fonteCottle, Lucy, e Mike Beadsworth. Spirochaetal infection (non-syphilis). Editado por Patrick Davey e David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0312.
Texto completo da fonteDondorp, Arjen M. Other tropical diseases in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0294.
Texto completo da fonteBerger, Stephen, e Inc Gideon Informatics. Leptospirosis: Global Status. Gideon Informatics, Incorporated, 2022.
Encontre o texto completo da fonteBerger, Stephen, e Inc Gideon Informatics. Leptospirosis: Global Status. Gideon Informatics, Incorporated, 2021.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Leptospirosis disease"
Hussein, Mansour F. "Leptospirosis (Weil’s Disease)". In Infectious Diseases of Dromedary Camels, 143–46. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-79389-0_22.
Texto completo da fonteWang, Guiqing, e Maria E. Aguero-Rosenfeld. "Lyme Disease, Relapsing Fever, and Leptospirosis". In Manual of Molecular and Clinical Laboratory Immunology, 419–32. Washington, DC, USA: ASM Press, 2016. http://dx.doi.org/10.1128/9781555818722.ch47.
Texto completo da fonteBolin, Carole. "Leptospirosis". In Emerging Diseases of Animals, 185–200. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555818050.ch9.
Texto completo da fonteFaine, S. "Leptospirosis". In Laboratory Diagnosis of Infectious Diseases, 344–52. New York, NY: Springer New York, 1988. http://dx.doi.org/10.1007/978-1-4612-3898-0_35.
Texto completo da fonteLichtenstein, Daniel, e Joseph Domachowske. "Leptospirosis". In Introduction to Clinical Infectious Diseases, 393–99. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-91080-2_37.
Texto completo da fonteDomachowske, Joseph, e Manika Suryadevara. "Leptospirosis". In Clinical Infectious Diseases Study Guide, 319–23. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50873-9_52.
Texto completo da fonteLi, Ruili, Hongjun Li e Aidong Zhang. "Leptospirosis". In Radiology of Infectious Diseases: Volume 2, 143–60. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9876-1_14.
Texto completo da fonteJyothi, J., e M. Bhavya Sree. "Leptospirosis". In The Handbook of Zoonotic Diseases of Goats, 232–35. GB: CABI, 2024. http://dx.doi.org/10.1079/9781800622852.0019.
Texto completo da fonteGrassmann, André Alex, Carlos Eduardo Pouey da Cunha, Everton Burlamarque Bettin e Alan John Alexander McBride. "Overview of Leptospirosis". In Neglected Tropical Diseases, 245–75. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-68493-2_8.
Texto completo da fonteLau, Colleen L. "Human Leptospirosis in Oceania". In Neglected Tropical Diseases, 177–92. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43148-2_7.
Texto completo da fonteTrabalhos de conferências sobre o assunto "Leptospirosis disease"
Sholikah, Sholikah, Atik Choirul Hidajah e Bambang Wuryono Kartika. "Evaluation of an Epidemiologic Investigation and Risk Factors Study of Leptospirosis Disease". In The 2nd International Symposium of Public Health. SCITEPRESS - Science and Technology Publications, 2017. http://dx.doi.org/10.5220/0007515004090413.
Texto completo da fonteRafiq, M., M. S. Arif, A. Raza e Humaira Ejaz. "Numerical Modeling for Transmission dynamics of Leptospirosis Disease in Juvenile and Adult Humans". In 2019 16th International Bhurban Conference on Applied Sciences and Technology (IBCAST - 2019). IEEE, 2019. http://dx.doi.org/10.1109/ibcast.2019.8667118.
Texto completo da fonteSinaga, Mikha Dayan, Frinto Tambunan, Charles Jhony Mantho Sianturi, Andrian Syahputra, Fithry Tahel e Siti Aliyah. "An Expert System for Diagnosing Leptospirosis Disease Using Forward Chaining and Bayes Theorem". In 2019 7th International Conference on Cyber and IT Service Management (CITSM). IEEE, 2019. http://dx.doi.org/10.1109/citsm47753.2019.8965338.
Texto completo da fonteCerrud-Rodriguez, R. C., T. Halasa, C. Epstein, I. M. Fernandez e O. Ariyibi. "An Intriguing Presentation of an Infrequent Disease - A Case Report of Urban Leptospirosis in the Bronx". In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6912.
Texto completo da fonteKorchemny, N., H. Allos, O. Teixeira Peixoto e A. Moraco. "Extensive Bilateral Pulmonary Nodular Disease: A Rare Case of Leptospirosis With Widespread Pulmonary Involvement in New England". In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5628.
Texto completo da fonteTateishi, Simone, e Werner Peter Marcon. "Immunization and deworming of cattle, horses, canines and domestic felines". In VI Seven International Multidisciplinary Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvimulti2024-059.
Texto completo da fonteVannaprathip, Narumol, Chanatda Tungwongjulaniam, Wimwiga Sakchainanon, Chadaporn Phiancharoen, Kasidet Suttiphatanan, Nopparuj Insawan, Itthiphon Mungetvit e Jirattha Kiatmonkong. "A Conceptual Framework for Gamification in Teaching Decision-Making to Control Diseases - Melioidosis and Leptospirosis". In 2023 IEEE 12th Global Conference on Consumer Electronics (GCCE). IEEE, 2023. http://dx.doi.org/10.1109/gcce59613.2023.10315288.
Texto completo da fonteRelatórios de organizações sobre o assunto "Leptospirosis disease"
Wainaina, Martin, Joseph Wasonga e Elizabeth Anne Jessie Cook. Epidemiology of human and animal leptospirosis in Kenya: A systematic review and meta-analysis of disease occurrence, serogroup diversity and risk factors. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, julho de 2024. http://dx.doi.org/10.37766/inplasy2024.7.0097.
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