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Villani, Marianicola. "L. Bernardi (ed.), La Finanza pubblica italiana – Rapporto 1995". Journal of Public Finance and Public Choice 13, n.º 1 (1 de abril de 1995): 77–78. http://dx.doi.org/10.1332/251569298x15668907540075.
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Stevenson, D. K., H. J. Vreman, W. Oh, A. A. Fanaroff, L. L. Wright, J. A. Lemons, J. Verter, S. Shankaran, J. E. Tyson e S. B. Korones. "Bilirubin production in healthy term infants as measured by carbon monoxide in breath". Clinical Chemistry 40, n.º 10 (1 de outubro de 1994): 1934–39. http://dx.doi.org/10.1093/clinchem/40.10.1934.
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Abstract To describe total bilirubin production in healthy term infants, we measured the end-tidal breath CO, corrected for ambient CO (ETCOc), with an automated sampler and electrochemical (EC) CO instrument. For infants of mothers with a negative Coombs' test, the ETCOc was 1.3 +/- 0.7 microL/L (n = 397) and the serum bilirubin on day 3 postpartum was 73 +/- 35 mg/L (n = 381). In contrast, the ETCOc for infants with ABO or Rh incompatibility, a positive direct Coombs' test, and bilirubin > 130 mg/L (n = 9) was significantly higher, 1.8 +/- 0.8 microL/L, than for those who had a positive Coombs' test result but whose bilirubin was < or = 130 mg/L (n = 12), 1.0 +/- 0.5 microL/L (P < 0.05). At 2 to 8 h postpartum seven term babies from mothers with insulin-dependent diabetes had ETCOc of 1.8 +/- 0.7 microL/L, significantly higher than that in the other term infants [1.3 +/- 0.7 microL/L (n = 390), P < 0.04]. Their bilirubin concentration at 72 +/- 12 h was also higher: 121 +/- 45 mg/L (n = 7) vs 73 +/- 34 mg/L (n = 374; P = 0.03). We conclude that ETCOc measurements may be helpful in understanding the mechanisms of jaundice in healthy term infants in a variety of conditions.
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Giachetti, L., D. Scaminaci Russo, M. Baldini, C. Goracci e M. Ferrari. "Reparability of Aged Silorane With Methacrylate-Based Resin Composite: Micro-Shear Bond Strength and Scanning Electron Microscopy Evaluation". Operative Dentistry 37, n.º 1 (1 de janeiro de 2012): 28–36. http://dx.doi.org/10.2341/10-397-l.
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Lheureux-Godbille, Catherine. "Barbarie et hérésie dans l'?uvre de saint Ambroise de Milan (374-397)". Le Moyen Age CIX, n.º 3 (2003): 473. http://dx.doi.org/10.3917/rma.093.0473.
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McGrath, P. A., J. R. Bourke, G. J. Huxham e S. W. Manley. "Electrical responses of cultured thyroid cells to serotonin". Journal of Endocrinology 107, n.º 3 (dezembro de 1985): 397–401. http://dx.doi.org/10.1677/joe.0.1070397.
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ABSTRACT Cultured porcine thyroid cells, maintained in the differentiated state by dibutyryl cyclic AMP, responded to serotonin (5-HT; 10 nmol/l to 1 μmol/l) with a depolarization of the membrane potential, but did not respond to histamine (100 μmol/l) or dopamine (1 μmol/l). The resting membrane potential of these cells was about − 71 mV, maximal concentrations of 5-HT (1 μmol/l) inducing a depolarization to approximately −53 mV. Methysergide or phenoxybenzamine, but not propranolol, abolished the response to 5-HT. Sensitivity to 5-HT was reduced by previous exposure of cultures to TSH, the β-adrenoceptor agonist salbutamol or 5-HT itself. J. Endocr. (1985) 107, 397–401
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Dormagen, Johann B. "Book Review". Acta Radiologica 51, n.º 3 (abril de 2010): 360. http://dx.doi.org/10.3109/02841851003590734.
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Emergency Radiology: The Requisites. By J. A. Soto and B. C. Lucey. Philadelphia, PA: Mosby Elsevier, 2009. ISBN 978-0-323-05407-2. 397 pages. Price (hardcover): € 75. Emergency Radiology Case Review Series. By S. E. Mirvis, K. Shanmuganathan, L. Miller, and C. Sliker. Philadelphia, PA: Mosby Elsevier. ISBN 978-0-323-04957-3. 415 pages. Price (paperback): €39.
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N, Enkhtsetseg, Altankhuu B e Narangerel B. "Study of leptospirosia in animal and livestock". Mongolian Journal of Agricultural Sciences 26, n.º 01 (30 de abril de 2019): 34–41. http://dx.doi.org/10.5564/mjas.v26i01.1195.
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Leptospirosis is a zoonotic bacterial disease that affects vulnerable populations such as rural subsistence farmers and urban slum dwellers. Leptospirosis is an infectious disease caused by pathogenic organisms belonging to the genus leptospira, that are transmitted directly or indirectly from animals to humans. In Mongolian human cases of leptospirosis has not been reported yet and this zoonotic disease not well study. We had use the kit in order to detect Pomona, Tarassovi, Hebdomadis, Icterohaemorrhagiae, Grippotyphosa, Sejroe and Canicola serotype by Enzyme-linked immunosorbent assay (ELISA) test. We analyzed 397 samples of bovine serum by indirect ELISA. The bovine serum samples were collected from Selenge province, and out of 101 samples 2 were positive. And, out of 171 bovine 1 serum was positive in Tov province. In contrast, no positive samples detected in 137 swine serum. Linnodee leptospira /ireland/- ELISA kit can detect a swine Bratislava serotype and cattle Hardjo serotype. To detect Hardjo serotype, 397 samples of cattle serum and 137 samples of swine serum were investigated. The 29 serum of cattle were positive, which has 7.3% infection rate, and, only one swine sera was positive out of 137, that has 0.73% infection rate. The 137 swine serum were tested by ELISA, which can detect Leptospira Bratislava serotype; and 12 out of that were positive. This indicates 8.7% of all sample are positive. Total of 397 bovine sera were examined by ELISA and specific antibody against Pomona, Tarassovi, Hebdomadis, Icterohaemorrhagiae, Grippotyphosa, Sejroe and Canicola serotype detected in 0,75 % (3 sera samples). Hardjo serotype detected in 7.3 % (29 sera) of bovine samples and 7.6 % (1 serum) of 13 swine sera samples and furthermore, bratislava serotype antibody detected in 8.7% (12 sera) of the pigs included in our study. Our study indicates that risk of human leptospirosis infection through animal derived food consumption, soil and water contamination is present due to prevalence of hardjo and bratislava serotype in cattle and pig farms. These results correlates with study conducted by Odontsetseg N. PhD in 2005 which stated that Hardjo serotype of Leptospira interrogans was detected in cattle herd in our country and these suggest that leptospirosis is prevalent in certain regions of our country.
Мал амьтны лептоспирозийн тандан судалгааны дүн
Хураангуй: Мал амьтны гаралтай хүнсний бүтээгдэхүүн ус, хөрсөөр дамжин хүнд халдварладаг зооноз өвчин болох Лептоспирозийн танадан судалгааг Булган, Орхон, Сэлэнгэ, Төв аймгууд болон Улаанбаатар хот орчмоос цуглуулсан үхрийн 721, гахайн 169, зарим мэрэгч амьтдын 108, усны 22 нийт 1020 сорьцыг ийлдэс судлал болон молекул биологи, нян судлалын аргаар шинжлэв. Судалгааны дүнд шинжилгээнд хамрагдсан нийт 397 үхрийн сорьцны 32 буюу 8.06%, 137 гахайн сорьцны 13 буюу 9.4%-д нь L. pomona, L. tarassovi, L. hebdomadis, L. icterohaemorrhagiae, L. grippotyphosa, L. sejroe, L. canicola, L. hardjo, L. bratislava хэвшлүүдийн эсрэг үүссэн өвөрмөц эсрэгбием тус тус илрэв. Лептоспирозийн байгалийн дамжуулагч болох мэрэгчийн 108-н сорьцонд Полимериазан Гинжин Урвал (ПГУ) тавихад 8 сорьц буюу 7.4%-д нь лептоспирозийн G1, G2 генийн өвөрмөц бүтээгдэхүүн илэрсэн болно. Ийлдэс судлал, ПГУ- аар эерэг гарсан сорьцуудад үүсгэгч илрүүлэх нян судлалын шинжилгээ хийсэн боловч үүсгэгч өсгөвөрлөгдсөнгүй. Манай орны Орхон, Сэлэнгийн сав газар, Архангай, Төв аймаг, Улаанбаатар хот орчмын үхэр, гахай, мэрэгчидийн сорьц лептоспирозоор эерэг дүн үзүүлсэн нь манай орны мал амьтан, мэрэгчидэд өвчний халдварлалт байгааг харуулж байна.
Түлхүүр үг: Leptospira, үүсгэгч, өвөрмөц эсрэгбием, ийлдсийн хэвшил, ген
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Purdy, S. J., B. J. Whitehouse e D. R. E. Abayasekara. "Stimulation of steroidogenesis by forskolin in rat adrenal zona glomerulosa cell preparations". Journal of Endocrinology 129, n.º 3 (junho de 1991): 391–97. http://dx.doi.org/10.1677/joe.0.1290391.
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ABSTRACT The actions of forskolin have been investigated to determine to what extent its effects on steroidogenesis in rat adrenal preparations are dependent on activation of adenylate cyclase. In zona glomerulosa preparations, stimulation of both aldosterone and corticosterone production was obtained at concentrations of forskolin between 1 and 10 μmol/l. The effects of 10 μmol forskolin/l were additive with those of low doses (1 pmol/l) of corticotrophin (ACTH), but not with those of high doses (1 nmol/l) of ACTH. In contrast, in zona fasciculata/reticularis cells, doses of forskolin up to 10 μmol/l produced no significant stimulation of corticosterone production either alone or in the presence of ACTH (1 pmol/l and 1 nmol/l). The response to 1 nmol ACTH/l was attenuated in the presence of forskolin (10 μmol/l) in both zona glomerulosa and zona fasciculata/reticularis cell preparations. Cyclic AMP production increased progressively with dose up to 100 μmol forskolin/l in zona glomerulosa cells, whereas corticosterone production was maximal between 10 and 30 μmol forskolin/l and decreased at 100 μmol forskolin/l. In zona fasciculata/reticularis cells, cyclic AMP production was also increased by forskolin (1 and 10 μmol/l). The stimulation of zona glomerulosa steroido-genesis by forskolin (1–10 μmol/l) and ACTH (1–100 pmol/l) were both reduced by the adenylate cyclase inhibitor, N6-phenylisopropyladenosine (100 μmol/l). The calcium channel inhibitor, nifedipine, only reduced the steroidogenic response to forskolin (3 μmol/l) at doses of 300 μmol/l whereas the response to 8·4 mmol K+/l was inhibited at 10 μmol nifedipine/1. Although there is some dissociation between the effects of forskolin on cyclic AMP and steroidogenesis, the results are generally consistent with the view that the effects of forskolin in rat zona glomerulosa cells are mainly dependent on activation of adenylate cyclase. This contrasts with the effects of forskolin in bovine fasciculata cells which are reported to be mediated by activation of voltage-regulated calcium channels. Journal of Endocrinology (1991) 129, 391–397
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Lippi, Ilaria, Francesca Perondi, Eleonora Gori, Alessio Pierini, Lucrezia Bernicchi e Veronica Marchetti. "Serum Bicarbonate Deficiency in Dogs with Acute and Chronic Kidney Disease". Veterinary Sciences 10, n.º 5 (19 de maio de 2023): 363. http://dx.doi.org/10.3390/vetsci10050363.
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Serum bicarbonate deficiency is a disorder frequently found in human patients with acute (AKI) and chronic (CKD) kidney disease, due to abnormalities in kidney generation and reabsorption of bicarbonate. Although alkali supplementation is usually performed in both humans and veterinary CKD patients, data regarding the frequency of bicarbonate disorders in AKI and CKD dogs are scarce. The aim of the present study is to assess the frequency and the severity of bicarbonate deficiency of dogs affected by AKI, acute chronic kidney disease (ACKD), and CKD, and to investigate its possible association with the IRIS grade/stage as well as with disorders of calcium phosphate metabolism. A retrospective evaluation of the serum biochemical panels of all dogs with diagnoses of AKI, ACKD, and CKD referred to the nephrology and urology service of the Veterinary Teaching Hospital of the University of Pisa, between January 2014 and January 2022, was performed. Bicarbonate deficiency was defined as serum bicarbonate < 22 mmol/L and classified as moderate (between 18 and 22 mmol/L) or severe (<18 mmol/L). Serum bicarbonate deficiency was found in 397/521 dogs (76%), of which 142/397 (36%) showed moderate deficiency, and 255/397 (64%) severe deficiency. Dogs with AKI and ACKD showed a significantly higher frequency of bicarbonate deficiency (p = 0.004) and severe forms compared to CKD dogs (p = 0.02). In AKI and ACKD dogs, a negative linear correlation was found between serum bicarbonate and serum creatinine, urea, and phosphate. The frequency of bicarbonate deficiency was higher in the later stages of the disease in both AKI (p = 0.01), ACKD (p = 0.0003), and CKD dogs (p = 0.009). Dogs with serum CaxP ≥ 70 mg2/dL2 showed a higher frequency of bicarbonate deficiency (p = 0.01) and showed severe forms (p = 0.01) compared to dogs with CaxP < 70 mg2/dL2. Serum bicarbonate deficiency seems to be a very frequent disorder in both AKI, ACKD, and CKD dogs, with an increasing frequency and severity in more advanced stages of kidney disease. The higher frequency and severity of bicarbonate deficiency in AKI and ACKD may be caused by a more severe and sudden loss of kidney function, or extra-renal factors. Finally, the association between frequency and severity of bicarbonate deficiency and abnormal CaxP may suggest a potential connection between metabolic acidosis and bone mineral disorders.
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Yue-Gang, Zhou, Naoko Norioka, Li Shao-Liang e Shigemi Norioka. "Cloning and nucleotide sequence of the cDNA encoding a β-1,3-glucanase-like protein secreted from growing pollen tubes of Japanese pear (Pyrus pyrifolia)". Chinese Journal of Agricultural Biotechnology 2, n.º 1 (abril de 2005): 53–58. http://dx.doi.org/10.1079/cjb200549.
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AbstractA pollen cDNA library of Japanese pear (Pyrus pyrifolia) from the family Rosaceae was constructed and a cDNA (bgn-1) of 1408 bp, which encodes a protein (BGN-1) secreted from growing pollen tubes, was cloned and sequenced. bgn-1 cDNA is composed of a 5′-untranslated region of 47 bp, an open reading frame of 1194 bp encoding 397 amino acid residues and a complete 3′-untranslated region of 167 bp. Alignment of the deduced amino acid sequence of bgn-1 with that of barley (Hordeum vulgare) β-1,3-glucanase (GII) showed 39.7% amino acid identity. Several residues that were critical for the function of GII were conserved in the deduced BGN-1 polypeptide. Moreover, hydrophobic cluster analysis (HCA) showed an overall HCA homology score of 87.1% and analysis of BGN-1 with the 3D-PSSM program predicted a three-dimensional structure of BGN-1 highly homologous to that of barley GII with ≥95% certainty. These results suggest that the cloned bgn-1 cDNA encodes a β-1,3-glucanase-like protein in Japanese pear. The predicted mature protein (375 amino acids) has a theoretical molecular mass of 40 723 Da, a basic pI of 9.59 and a diagnostic amino acid residue mode of D, L, S and L, which is very similar to that of growth-related subfamily D (D, L, S and Q) in cereals. A ProXXPro repeat is also found between positions 352 and 367 in the C-extension region.
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Boneva, Desislava. "Damages on hazelnut kernels caused by Penicillium spp." Agricultural Sciences 15, n.º 38 (8 de novembro de 2023): 92–97. http://dx.doi.org/10.22620/agrisci.2023.38.0010.
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The presence of Penicillium spp. was observed during a laboratory examination of nuts (Corylus avellana L.) collected from April 2019 to April 2023 from hazelnut trees, grown in different regions of Bulgaria. The obtained isolates were identified following the Koch’s postulates and their cultural and morphological characteristics were studied. Three-hundred ninety seven (397) samples, with suspected presence of pathogen, were taken from nuts. Penicillium spp. strains were identified as a cause for damages in approximately 2% of all examined kernels. Keywords: Penicillium spp., hazelnut, pathogenicity
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Viñas, Jordi, Núria Sanz, Luis Peñarrubia, Rosa-Maria Araguas, José-Luis García-Marín, Maria-Inés Roldán e Carles Pla. "Genetic population structure of European anchovy in the Mediterranean Sea and the Northeast Atlantic Ocean using sequence analysis of the mitochondrial DNA control region". ICES Journal of Marine Science 71, n.º 2 (7 de setembro de 2013): 391–97. http://dx.doi.org/10.1093/icesjms/fst132.
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Abstract Viñas, J., Sanz, N., Peñarrubia, L., Araguas, R-M., García-Marín, J-L., Roldán, M-I., and Pla, C. 2014. Genetic population structure of European anchovy in the Mediterranean Sea and the Northeast Atlantic Ocean using sequence analysis of the mitochondrial DNA control region. – ICES Journal of Marine Science, 71: 391–397. The European anchovy (Engraulis encrasicolus) exhibits a complex population structure in the Mediterranean Sea and Northeast Atlantic Ocean. To resolve the population genetic structure of this species, we surveyed sequence variability in the mitochondrial (mtDNA) control region in samples (n = 563) from 13 locations in the Northeast Atlantic, the Bay of Biscay, and the Mediterranean Sea. Based on pairwise ΦSTs, SAMOVA, and multidimensional scaling, a complicated population structure composed of multiple populations emerged. Combining these results with those from previous population studies based on mitochondrial and nuclear markers, we identified nine genetically differentiated European anchovy populations: (i) Canary Islands; (ii) Cádiz; (iii) Alborán Sea; (iv) Garona; (v) Arcachon and Donostia; (vi) a large population in the northwestern Mediterranean, including Cadaqués, Gulf of Lyon, Elba, and Sicily; (vii) southern Adriatic; (viii) northern Adriatic; and (ix) Aegean Sea. We suggest that independent management strategies should be implemented for each genetically differentiated population, and, in cases where several fisheries stocks are recognized within an area of genetic homogeneity, each stock should be managed separately.
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Alimuddin, Alimuddin. "Assessment of Ground Water Quality in Rajajinagar of Bangalore". Current World Environment 10, n.º 1 (30 de abril de 2015): 318–20. http://dx.doi.org/10.12944/cwe.10.1.40.
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Water borne diseases continue to be a dominant cause of water borne morbidities and mortality all over the world. Hence, drinking water needs to be protected from pollution and biological contamination. Ground water samples were collected from ten different sampling point in Rajajinagar area of Bangalore and analysed for water quality parameters viz. pH, total alkalinity, chloride, total dissolved solids, electrical conductivity, sodium, potassium, calcium, magnesium, dissolved oxygen, BOD, COD and total hardness. The pH value of the study area ranges between 7.3 to 8.4 indicating that ground water is slightly alkaline. The total alkalinity are varied in the range from 122 to 282 mg/l which is well within the limit prescribed by BIS. The TDS value found from 397 to 546 mg/l. The values of hardness of water ranges from 125 to 267 mg/l which is within the prescribed limit as per BIS.
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Collins-Camones, Jaime Antonio, Fiorella Vanesa Loyola-Salvatierra, Roxana Liliana Gamarra-Lazo, Celia Joanna Páucar-Miranda, Moisés Gonzalo Cárdenas-Ruiz, Nikolai Grande-Castro, Juan Carlos Palacios-Calcina et al. "Pruebas de laboratorio y desenlace clínico en pacientes hospitalizados por la COVID-19". Revista de la Sociedad Peruana de Medicina Interna 34, n.º 2 (26 de junho de 2021): 53–60. http://dx.doi.org/10.36393/spmi.v34i2.596.
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Objetivo: Identificar los resultados de laboratorio asociados con el riesgo de muerte en pacientes hospitalizados por la COVID-19. Material y métodos: estudio de cohorte retrospectivo de pacientes admitidos por la COVID-19 en el Hospital Nacional EsSalud Guillermo Almenara Irigoyen de Lima, entre el 21 de marzo y el 12 de mayo 2020. Las pruebas de laboratorio incluidas en el estudio fueron las del ingreso al hospital. Se hizo un análisis de Cox para determinar factores asociados con muerte. Resultados: un total de 433 pacientes fueron incluidos: 253 casos (58%) con RT-PCR positivo y 180 casos (42%) con prueba rápida de anticuerpos reactiva. El 55% (240/433) y el 59% (256/433) tuvo leucocitosis y linfopenia relativa (≤10%), respectivamente. El 56% (49/87) tuvo dímero-D mayor a dos mg/L. Cifras mayores al normal se presentaron en 39% (152/393) para urea y 19% (77/397) para creatinina, así como en 73% (228/313) para aspartato aminotransferasa y 62% (193/310) para alanina aminotransferasa. De otro lado, 54% (180/336) tuvo proteína C reactiva mayor a 150 mg/L, 42% (108/258) lactato deshidrogenasa mayor a 450 U/L y 57% (52/91) ferritina mayor a mil ng/mL De forma subsiguiente, leucocitosis (HRa 2,72; IC955; 1,12- 6,60), menos de trescientas mil plaquetas por mm3 (HRa 2,36; IC95%; 1,23-4,52), e incrementos en los valores normales de creatinina (HRa 3,03; IC95%; 1,41-6,48) como de lactato deshidrogenasa por encima de 450 U/L (HRa 2,41; IC95%; 1,29-4,49) se asociaron de forma independiente con muerte. Conclusión: la muerte de los pacientes hospitalizados por la COVID-19 fue asociada de forma independiente con leucocitosis, menos de trescientas mil plaquetas por mm3, creatinina por encima del normal y lactato deshidrogenasa mayor a 450 U/L.
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Spitzer, S. G., B. J. Warn-Cramer, C. K. Kasper e S. P. Bajaj. "Replacement of isoleucine-397 by threonine in the clotting proteinase factor IXa (Los Angeles and Long Beach variants) affects macromolecular catalysis but not l-tosylarginine methyl ester hydrolysis. Lack of correlation between the ox brain prothrombin time and the mutation site in the variant proteins". Biochemical Journal 265, n.º 1 (1 de janeiro de 1990): 219–25. http://dx.doi.org/10.1042/bj2650219.
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Previously, from the plasma of unrelated haemophilia-B patients, we isolated two non-functional Factor IX variants, namely Los Angeles (IXLA) and Long Beach (IXLB). Both variants could be cleaved to yield Factor IXa-like molecules, but were defective in catalysing the cleavage of Factor X (macromolecular substrate) and in binding to antithrombin III (macromolecular inhibitor). In the present study we have identified the mutation of IXLA by amplifying the exons (including flanking regions) as well as the 5′ end of the gene by polymerase-chain-reaction (PCR) method and sequencing the amplified DNA by the dideoxy chain-termination method. Comparison of the normal IX and IXLA sequences revealed only one base substitution (T----C) in exon VIII of IXLA, with a predicted replacement of Ile-397 to Thr in the mature protein. This mutation is the same as found recently for IXLB. The observation that IXLB and IXLA have the same mutation is an unexpected finding, since, on the basis of their ox brain prothrombin time (PT, a test that measures the ability of the variant Factor IX molecules to inhibit the activation of Factor X by Factor VIIa-tissue factor complex), these variants have been classified into two different groups and were thought to be genetically different. Our observation thus suggests that the ox brain PT does not reflect the locus of mutation in the coding region of the variant molecules. However, our analysis suggests that the ox brain PT is related to Factor IX antigen concentration in the patient's plasma. Importantly, although the mutation in IXLA or IXLB protein is in the catalytic domain, purified IXaLA and IXaLB hydrolyse L-tosylarginine methyl ester at rates very similar to that of normal IXa. These data, in conjunction with our recent data on Factor IXBm Lake Elsinore (Ala-390----Val mutant), strengthen a conclusion that the peptide region containing residues 390-397 of normal Factor IXa plays an essential role in macromolecular substrate catalysis and inhibitor binding. However, the two mutations noted thus far in this region do not distort S1 binding site in the Factor IXa enzyme.
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Morrone, Juan J., Raúl Muñiz, Julieta Asiain e Juan Márquez. "LISTA DE LAS ESPECIES DE CURCULIONOIDEA (INSECTA: COLEOPTERA) DEPOSITADAS EN LA COLECCIÓN DEL MUSEO DE ZOOLOGÍA "ALFONSO L. HERRERA", FACULTAD DE CIENCIAS, UNAM (MZFC)". ACTA ZOOLÓGICA MEXICANA (N.S.), n.º 87 (17 de dezembro de 2002): 147–65. http://dx.doi.org/10.21829/azm.2002.87871806.
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La colección del Museo de Zoología "Alfonso L. Herrera" incluye 1,148 especímenes de Curculionoidea, que pertenecen a 397 especies, 217 géneros y 14 familias. La familia mejor representada es Curculionidae, con 342 especies, seguida de Dryophthoridae (12), Erirhinidae (8), Belidae (7), Oxycorynidae (6), Brentidae (4), Nemonychidae (4), Rhynchitidae (4), Anthribidae (3), Apionidae (2), Brachyceridae (2), Attelabidae (1), Ithyceridae (1) y Raymondionymidae (1). Muchos de los especímenes provienen de otros países (Argentina, Chile, Brasil y E.U.A., entre otros). La mayoría de los ejemplares mexicanos son de los estados de Hidalgo (44 especies), Morelos (13), Nayarit (12) y Veracruz (12).
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Rawstron, Andy C., Walter Gregory, Ruth M. de Tute, Faith E. Davies, Susan E. Bell, Mark T. Drayson, Gordon Cook et al. "Minimal Residual Disease (MRD) in Myeloma: Independent Outcome Prediction and Sequential Survival Benefits per Log Tumour Reduction". Blood 124, n.º 21 (6 de dezembro de 2014): 3416. http://dx.doi.org/10.1182/blood.v124.21.3416.3416.
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Abstract Minimal residual disease (MRD), as assessed by flow cytometry is a powerful predictor of outcome in multiple myeloma (MM). We and others have previously demonstrated that such analyses are informative in patients treated with autologous stem cell transplant (ASCT) and non-transplant regimens. It predicts outcome in patients in conventional CR and is applicable to patients with standard and adverse risk cytogenetics. As a consequence MRD assessment is under consideration as a surrogate endpoint for clinical trials. This is urgently needed in MM as >5yrs follow-up is typically required to demonstrate survival differences in trials of upfront therapy. If surrogate end points are to be used in clinical trials it is essential that a reproducible effect is demonstrable using multivariate models. Previous studies have confirmed the effect of MRD on PFS but a consistent effect on OS has been not been definitively shown. This may in part be due to the availability of effective salvage therapy but it is also possible that the traditional threshold of 10-4 for analysis and the categorization of patients as MRD-postive or negative is suboptimal. Flow cytometry does provide a quantitative assessment of residual tumour over a large range and the degree of tumour depletion may be more informative than a positive-negative analysis. 397 patients from the MRC Myeloma IX trial were included in this analysis. Patients were randomly assigned to CTD (cyclophosphamide, thalidomide, and dexamethasone) or CVAD (cyclophosphamide, vincristine, doxorubicin, and dexamethasone) induction for 4-6 cycles followed by standard high-dose melphalan (HDM) ASCT. BM aspirates were obtained at day 100 for MRD analysis. 500,000 cells were evaluated with six-colour antibody combinations including CD138/CD38/CD45/CD19 with CD56/CD27 in all cases and CD81/CD117 in additional cases as required. PFS and OS data analysis was landmarked from the date of the MRD assesment. Of the 397 patients with MRD data available at day 100 after ASCT, 247/397 (62.2%) achieved <0.01% MRD. The level of residual disease varied across four logs in MRD-positive patients (0.01-<0.1% in 49/397, 0.1-<1% in 72/397, 1-<10% in 26/397 and ≥10% in 3/397). The PFS and OS for individuals with ≥1% residual disease was comparable to individuals with a PR/MR/SD confirming that MRD assessment is most relevant in CR. The level of MRD correlated with outcome. The median PFS for patients with ≥10% MRD at day 100 after ASCT was 0.8 years, with 1-<10% MRD was 1.7 years, with 0.1-<1% MRD was 1.9 years, with 0.01-<0.1% MRD was 2.7 years and for patients with <0.01% MRD was 3.1 years (P<0.001). The median OS for these groups was 1 yr, 4 yrs, 5.9 yrs, 6.8 yrs and for patients with <0.01% MRD not reached with >7.5 yrs median follow-up (P<0.001, see figure). A Cox proportional hazards model was used to further evaluate factors influencing outcome. B2M and MRD were log-transformed and along with age were considered as continuous variables. ISS, haemoglobin (<115g/l), platelets (<150x10^9/l) and cytogenetics were used as stratification factors. Cytogenetic groups were classified as unfavourable for patients with gain(1q), del(1p32), t(4;14), t(14;20), t(14;16), and del(17p), or favourable for hyperdiploidy, t(11;14) and t(6;14), or unknown/inevaluable. MRD assessment (χ2 11.8, P=0.0006) and cytogenetics (χ2 35.5, P=<0.0001) were the only factors that retained significance in this multivariate model. Conventional categorical response, ISS and B2M were not predictive of OS (p=0.99, 0.16 and 0.56 respectively). We would conclude that MRD quantitation is more informative than a positive or negative categorization with a 10-4 threshold and independently predicts outcome. In this analysis we were able to demonstrate an approximate 1 year survival benefit per log tumour depletion. A lower cutpoint for predicting improved outcome was not reached and more sensitive assays will likely improve outcome prediction further. This data strongly supports the role of MRD assessment as a surrogate endpoint in clinical trials. Figure 1 Figure 1. Disclosures Rawstron: Celgene: Consultancy; BD Biosciences: Consultancy, Intrasure Patents & Royalties. Gregory:Celgene: Consultancy. Davies:Celgene: Consultancy, Honoraria; Janssen-Cilag: Consultancy, Honoraria; Novartis: Consultancy. Cook:Celgene: Consultancy, Honoraria, Research Funding; Janssen-Cilag: Consultancy, Honoraria. Jackson:Celgene: Honoraria; Janssen-Cilag: Honoraria. Morgan:Celgene: Consultancy, Honoraria, Research Funding; Janssen-Cilag: Consultancy, Honoraria; Merck: Consultancy, Honoraria; Novartis: Consultancy, Honoraria. Owen:Celgene: Consultancy, Honoraria, Research Funding.
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D. MAHESH, S. L. BHATTIPROLU, V. PRASANNA KUMARI e CH. CHIRANJEEVI. "BIOCHEMICAL ANALYSIS OF RESISTANT AND SUSCEPTIBLE COTTON GENOTYPES AGAINST ALTERNARIA AND CORYNESPORA". Journal of Research ANGRAU 52, n.º 1 (31 de março de 2024): 39–50. http://dx.doi.org/10.58537/jorangrau.2024.52.1.05.
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Cotton leaf samples of 10 genotypes LAHB-1, L799, L 389, L770 and LPS 141 (resistant); L 1060, L 2551, L 2503, L 397 and L 2559 (susceptible) along with one control (Jaadoo BG II hybrid) against Alternaria and Corynespora were analyzed at flowering and boll development stages for the estimation of total phenols, total proteins, total sugars, reducing sugars, nonreducing sugars, chlorophyll and peroxidises. Results showed that all the biochemical parameters,except peroxidase enzyme, showed decreasing trend from flowering to boll development stage. There was significant reduction in phenols at flowering stage (16.23% to 53.30%) and at boll development stage (22.71% to 58.37%), total proteins at flowering stage(16.91% to 58.19%) and at boll development stage (9.51% to 51.43%), total sugars at flowering stage (15.71% to 51.32%) and at boll development stage (28.10% to 65.05%), reducing sugars at flowering stage (9.59% to 53.00%) and at boll development stage (35.56% to 69.93%), nonreducing sugars at flowering stage (18.38% to 49.53%) and at boll development stage (10.53% to 92.84%) and total chlorophyll at flowering stage (24.80% to 48.46%) and at boll development stage (9.19% to 32.86%). However, there was increase in peroxidase content at flowering stage (59.94% to 225.35%) and at boll development stage (38.79% to 138.79%) as the disease severity increased.
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Capano, Giliberto. "Bruno Dente (a cura di), Le politiche pubbliche in Italia, Bologna, il Mulino, 1990, pp. 397, L. 32.000." Italian Political Science Review/Rivista Italiana di Scienza Politica 22, n.º 1 (abril de 1992): 161–64. http://dx.doi.org/10.1017/s0048840200018281.
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McCALLUM, ANNA W., e GARY C. B. POORE. "Two crested and colourful new species of Lebbeus (Crustacea: Caridea: Hippolytidae) from the continental margin of Western Australia". Zootaxa 2372, n.º 1 (26 de fevereiro de 2010): 126–37. http://dx.doi.org/10.11646/zootaxa.2372.1.13.
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Two new species of hippolytid shrimp are described from the continental margin of Western Australia, Lebbeus clarehannah sp. nov. from one female specimen collected off Bald Island, WA, at depths of 408–431 m and Lebbeus cristagalli sp. nov. from ten specimens collected off north-western Australia at depths of 397–458 m. Both species belong to the group of Lebbeus species possessing epipods on only the first two pairs of pereopods. Within this group, they are similar to L. yaldwyni Kensley, Tranter & Griffin, 1987 from NSW, Australia, and L. compressus Holthuis, 1947 from Japan in possessing a high crest on the carapace. These crested species of Lebbeus are reviewed. They can be distinguished from one another by the shape of the carapace crest, the number of spines on maxilliped 3 and by colour pattern. A key to all crested species and colour photos of the Australian species are provided.
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Nikolaychuk, Pavel Anatolyevich. "UV-Spectrophotometric Determination of the Active Pharmaceutical Ingredients Meloxicam and Nimesulide in Cleaning Validation Samples with Sodium Carbonate". J 6, n.º 2 (22 de abril de 2023): 248–66. http://dx.doi.org/10.3390/j6020019.
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The spectrophotometric methods of determination of the active pharmaceutical ingredients meloxicam and nimesulide were reviewed and a simple UV-spectrophotometric method for the determination of these active pharmaceutical ingredients in industrial equipment cleaning validation samples was proposed. The methods were based on extraction of the residual quantities of meloxicam and nimesulide from the manufacturing equipment surface by the concentrated sodium carbonate solution and the subsequent UV-spectrophotometric determination of the basic forms of the drugs at the wavelength of 362 nm for meloxicam and at 397 nm for nimesulide. The calibration graphs were linear in the range from 5 to 25 mg/L of both nimesulide and meloxicam, the molar attenuation coefficients were 6100 m2/mol for nimesulide and 9100 m2/mol for meloxicam, the limit of detection was 0.8 mg/L for nimesulide and 1.9 mg/L for meloxicam and the limit of quantification was 2.5 mg/L for nimesulide and 5.8 mg/L for meloxicam. The methods were selective with respect to the common excipients, showed a good accuracy (the relative uncertainty did not exceed 7%) and precision (the relative standard deviation did not exceed 4%), did not require lengthy sample preparation or sophisticated laboratory equipment and were suitable for the routine analysis of cleaning validation samples.
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Turner, John D. "Karen L. King, The Secret Revelation of John. Cambridge, MA: Harvard University Press, 2006. xvi+397 pp. $25.00 (cloth)." Journal of Religion 87, n.º 1 (janeiro de 2007): 101–3. http://dx.doi.org/10.1086/511346.
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Wang, Q., M. Su, W. Zhu, X. Li, Y. Jia, P. Guo, Z. Chen, W. Jiang e X. Tian. "Growth inhibition of Microcystis aeruginosa by white-rot fungus Lopharia spadicea". Water Science and Technology 62, n.º 2 (1 de julho de 2010): 317–23. http://dx.doi.org/10.2166/wst.2010.214.
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Harmful cyanobacterial blooms cause water deterioration and threaten human health. It is necessary to remove harmful cyanobacteria with useful methods. A bio-treatment may be one of the best ways to do this. A strain of specific white-rot fungus, Lopharia spadicea, with algicidal ability was isolated. Its algicidal ability on algae under various conditions was determined using three main influence factors: initial chlorophyll-a content, initial pH, and algal cell mixture. The result showed that the chlorophyll-a content of Microcystis aeruginosa FACHB-912, Oocystis borgei FACHB-1108, and Microcystis flos-aquae FACHB-1028 decreased from 798 ± 13, 756 ± 40, and 773 ± 24 μg/L to 0 within 39 h. L. spadicea could also remove more than 95% chlorophyll-a when initial chlorophyll-a content increased from 397 ± 13 to 2,132 ± 4 μg/L. Moreover, the strain has great removal ability under a broad initial pH range of 5.5 to 9.5. The chlorophyll-a content of the three algal strain mixtures decreased from about 672 ± 23 μg/L to 0 within 45 h. After superoxide dismutase (SOD) and malondialdehyde (MAD) were assessed in a co-culture of L. spadicea, it was observed that an increase in MAD content was correlated with the decrease in chlorophyll-a content of M. aeruginosa FACHB-912. This result suggested that the algae was not only greatly inhibited but also severely damaged by the fungus.
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Webler, Alberto Dresch, Claudio Fernando Mahler e Márcia Dezotti. "Tratamento de lixiviado por processos combinados: coagulação/floculação, air stripping, ozonização e lodo ativado". Engenharia Sanitaria e Ambiental 23, n.º 5 (22 de outubro de 2018): 901–11. http://dx.doi.org/10.1590/s1413-41522018162946.
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RESUMO Os lixiviados de áreas de disposição de resíduos municipais apresentam, em geral, alta complexidade, variabilidade, toxicidade, recalcitrância e alta concentração de nitrogênio amoniacal. Neste estudo, aplicaram-se técnicas combinadas para o tratamento de um lixiviado, a saber: coagulação/floculação (C/F), air stripping e ozonização, combinados com o tratamento por lodo ativado com/sem inserção de carvão ativado. O processo de C/F levou a uma redução na demanda química de oxigênio (DQO) de 58,1% e na cor, de 85,6%. O air stripping foi realizado em pH>12 e obteve-se diminuição dos níveis de nitrogênio amoniacal para abaixo de 60 mg.L-1. O processo de ozonização, com consumo de ozônio de 397 mgO3.L-1 e 2.376 mgO3.L-1, apresentou bons resultados, com aumento de 59,4% na relação DBO5/DQO e uma redução de toxicidade superior a 85%. Obteve-se melhor eficiência para o lodo ativado sem carvão ativado, com lixiviado pré-tratado por C/F + air stripping + ozonização (400 mgO3.L-1). Tal combinação resultou em uma redução de 90,6% na DQO do lixiviado e mais de 99% nos níveis de nitrogênio amoniacal.
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Hsu, Pi Shan. "Development of the Self-Determined Learning Motivation Scale: Analysis of Reliability and Validity". Applied Mechanics and Materials 411-414 (setembro de 2013): 2869–72. http://dx.doi.org/10.4028/www.scientific.net/amm.411-414.2869.
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The purpose of this study is aims to develop an inventory assessing self-determined motivation for e-Learning courses in college. The study involves 397 college students, with exploratory factor analysis and Cronbach alpha scale reliability, and the validity of the test. Self-determined learning motivation scale is accordance with the Learning Self-Regulation Questionnaire (SRQ-L) by Williams & Deci (1996) and Black & Deci (2000). It compiled and revised the initial inventory consisted of 14 items, it divided into four dimensions, such as, "Intrinsic motivation", " Identified regulation", Introjected Regulation ", and "External regulation", the total explained variance was 71.35%. The Cronbach alpha is .87, with acceptable construct validity and reliability of measurement tools, it can provide the future development of e-Learning courses.
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Pattoni, Maria Pia. "Democratic Paideia in Aeschylus’ Suppliants". Polis: The Journal for Ancient Greek Political Thought 34, n.º 2 (11 de novembro de 2017): 251–72. http://dx.doi.org/10.1163/20512996-12340126.
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Abstract The analysis of political language in Aeschylus’ Suppliants confirms the hypothesis that the form of government here represented is strongly influenced by contemporary Athens: prehistoric Argos turns out to be a sort of mirror of democratic Athens. It is no coincidence that the sequence running from the entrance of Pelasgus at l. 234 to the Danaids’ song of benediction (ll. 625-709) presents a dramatic pattern similar in several respects to that underlying in Eumenides 397-1002 (the scenes between the entrance of Athena and the Chorus’ prayer of blessing). Pelasgus (likewise Athena in Eumenides) imparts a sort of lesson on ‘democratic paideia’ to the Danaids, in view of their integration as metoikoi in the institutional structures of the polis.
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Ah-See, K. "MULTIDISCIPLINARY HEAD & NECK RECONSTRUCTION: A DEFECT-ORIENTED APPROACHM L Urken Wolters Kluwer/Lippincott Williams & Wilkins, 2009 ISBN 978 0 397 51835 7 pp 848 Price $399". Journal of Laryngology & Otology 124, n.º 10 (6 de janeiro de 2010): 1143. http://dx.doi.org/10.1017/s0022215109992581.
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Lemos, Valfredo Azevedo, Liz Oliveira dos Santos, Eldevan dos Santos Silva e Emanuel Vitor dos Santos Vieira. "Spectrophotometric Determination of Mercury in Water Samples After Preconcentration Using Dispersive Liquid–Liquid Microextraction". Journal of AOAC INTERNATIONAL 95, n.º 1 (1 de janeiro de 2012): 227–31. http://dx.doi.org/10.5740/jaoacint.11-198.
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Abstract A simple method for the determination of mercury in water samples after preconcentration using dispersive liquid–liquid microextraction is described. The procedure is based on the extraction of mercury in the form of a complex and its subsequent determination by spectrophotometry. The complex is formed between Hg(II) and 2-(2-benzothiazolylazo)-p-cresol. The detection at 650 nm is performed directly in the metal-rich phase, which is spread on a triacetylcellulose membrane. The method eliminates the need to use a cuvet or large quantities of samples and reagents. The parameters that influence the preconcentration were studied, and the analytical characteristics were determined. The enrichment factor and the consumptive index for this method were 64 and 0.16 mL, respectively. The LOD (3.3 μg/L) and LOQ (11.1 μg/L) were also determined. The accuracy of the method was tested by the determination of mercury in certified reference materials BCR 397 (Human Hair) and SRM 2781 (Domestic Sludge). The method was applied to the determination of mercury in samples of drinking water, sea water, and river water.
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Forsling, M. L., e K. Peysner. "Pituitary and plasma vasopressin concentrations and fluid balance throughout the oestrous cycle of the rat". Journal of Endocrinology 117, n.º 3 (junho de 1988): 397–402. http://dx.doi.org/10.1677/joe.0.1170397.
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ABSTRACT Observations were made of fluid balance and vasopressin concentrations throughout the oestrous cycle of normally cyclic female rats housed under a 12 h light: 12 h darkness regime. Plasma vasopressin concentrations were found to increase progressively during the light period, falling again during the night on all days of the cycle except pro-oestrus. On this day, peak vasopressin concentrations of 3·32 ± 0·8 pmol/l were seen between 10.00 and 12.00 h, with lower concentrations of 1·74± 0·22 pmol/l being seen between 18.00 and 19.00 h. Urine flow appeared to reflect the changes in plasma vasopressin concentrations, being significantly lower during the light phase, with a small increase being seen over this period on pro-oestrus. Pituitary vasopressin concentrations were highest between 09.00 and 10.00 h and fell progressively over each of the 4 days of the oestrous cycle. The changes in pituitary content were greater than could be accounted for in terms of the alterations in the plasma concentrations of vasopressin. J. Endocr. (1988) 117, 397–402
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Espinosa, Maria Fernanda, Marcos von Sperling e Matthew E. Verbyla. "Performance evaluation of 388 full-scale waste stabilization pond systems with seven different configurations". Water Science and Technology 75, n.º 4 (10 de dezembro de 2016): 916–27. http://dx.doi.org/10.2166/wst.2016.532.
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Waste stabilization ponds (WSPs) and their variants are one the most widely used wastewater treatment systems in the world. However, the scarcity of systematic performance data from full-scale plants has led to challenges associated with their design. The objective of this research was to assess the performance of 388 full-scale WSP systems located in Brazil, Ecuador, Bolivia and the United States through the statistical analysis of available monitoring data. Descriptive statistics were calculated of the influent and effluent concentrations and the removal efficiencies for 5-day biochemical oxygen demand (BOD5), total suspended solids (TSS), ammonia nitrogen (N-Ammonia), and either thermotolerant coliforms (TTC) or Escherichia coli for each WSP system, leading to a broad characterization of actual treatment performance. Compliance with different water quality and system performance goals was also evaluated. The treatment plants were subdivided into seven different categories, according to their units and flowsheet. The median influent concentrations of BOD5 and TSS were 431 mg/L and 397 mg/L and the effluent concentrations varied from technology to technology, but median values were 50 mg/L and 47 mg/L, respectively. The median removal efficiencies were 85% for BOD5 and 75% for TSS. The overall removals of TTC and E. coli were 1.74 and 1.63 log10 units, respectively. Future research is needed to better understand the influence of design, operational and environmental factors on WSP system performance.
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Hartmann, Katrin, e Jutta Hein. "Labordiagnostische Referenzbereiche bei Kaninchen". Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 31, n.º 05 (2003): 321–28. http://dx.doi.org/10.1055/s-0037-1622371.
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ZusammenfassungZiel der Arbeit war, Referenzwerte für Blutparameter bei Kaninchen verschiedener Rassen mit einer für die Praxis geeigneten Blutentnahmemethode zu erstellen. Zur Sammlung der Daten wurde Blut von 155 klinisch gesunden Kaninchen im Alter von sechs Wochen bis neuneinhalb Jahren aus der V. saphena lateralis entnommen. Für die folgenden Parameter wurden Referenzbereiche bestimmt: Hämatokrit (Hkt; 0,36-0,55 l/l), Hämoglobinkonzentration (Hb; 7,03-10,63 mmol/l), Erythrozytenzahl (5,36-8,13 ×1012/l), Erythrozytenindices (MCHC: 18,4-20,1 mmol/l, MCH: 1,14-1,37 fmol/l, MCV 59,3-69,6 fl), Leukozytenzahl (3,02-11,91 × 109/l), Differenzialblutbild (Monozyten: 0-756 × 106/l [0-12%], Lymphozyten: 1576-7870 × 106/l [32-81%], stabkernige neutrophile Granulozyten: 0 × 106/l (0%), segmentkernige neutrophile Granulozyten: 820-5031 × 106/l [15-61%], eosinophile Granulozyten: 0-82 × 106/l [0-1%], basophile Granulozyten: 0-518 × 106/l [0-7%], Thrombozytenzahl (193-725 × 109/l), die Enzymaktivitäten von Alaninaminotransferase (ALT; 0-61 IU/l), alkalische Phosphatase (AP; 0-397 IU/l), Aspartataminotransferase (AST; 0-28 IU/l), Glutamatdehydrogenase (0-19 IU/l), γ-Glutamyltransferase (γ-GT; 0-13 IU/l), Laktatdehydrogenase (LDH; 0-571 IU/l), Kreatinkinase (CK; 0-958 IU/l), α-Amylase (0-459 IU/l), Lipase (0-1587 IU/l) und Cholinesterase (0-3.564 IU/l), die Konzentrationen der Substrate Glukose (5,83-14,83 mmol/l), Fruktosamin (314-527 µmol/l), Gesamteiweiß (48,9-73,9 g/l) mit Auftrennung durch Elektrophorese (Albumin: 35,6-56,8 g/l [66,7-86,1%], α1-Globulin: 0,1-3,6 g/l [0,1-5,7%], α2-Globulin: 1,7-4,5 g/l [2,9-7,0%], α1-Globulin: 4,1-10,7 g/l [6,9-16,8%], γ-Globulin: 0,5-8,7 g/l [0,9-12,1%]), Cholesterin (0,31 bis 2,66 mmol/l), Triglyzeride (0,45-3,35 mmol/l), Serumgallensäuren (0,0-77,6 µmol/l), Bilirubin (0,29-2,53 µmol/l), Harnstoff (2,05-8,42 mmol/l) und Kreatinin (34-166 µmol/l) sowie der Elektrolyte Kalzium (3,1-3,9 mmol/l), Phosphat (0,81 bis 3,15 mmol/l), Magnesium (0,90-1,66 mmol/l), Natrium (139 bis 149 mmol/l), Kalium (3,7-6,3 mmol/l), Chlorid (93-109 mmol/l) und Eisen (20-59 µmol/l). Alters-(≤ 4 Monate und > 4 Monate) und Geschlechtsabhängigkeiten (männlich/weiblich) wurden ermittelt.
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Malgwi, K. D., B. Umaru, S. A. Chabri, N. Daniel, L. Sanya, U. A. Maina e S. Saka. "Assessment of Oxytetracycline and Penicillin G Residues Levels in Raw and Fermented Milk in Maiduguri, Northeastern Nigeria". Saudi Journal of Medical and Pharmaceutical Sciences 9, n.º 03 (3 de março de 2023): 140–49. http://dx.doi.org/10.36348/sjmps.2023.v09i03.001.
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This study was conducted to evaluate the presence and concentration of Oxytetracycline and Penicillin G residues in raw cow and Fermented milk consumed in Maiduguri, Northeastern Nigeria. A total of 172 (86 raw and 86 fermented) milk samples were randomly collected from different milk selling points in Maiduguri. A Spectrophotometer ultraviolet visible spectrum machine was used to detect and quantify the oxytetracycline and penicillin G residues in the milk samples. All samples (raw and fermented milk) tested positive for oxytetracycline and penicillin G residues with a mean residual concentration of 36 µg/L and 20 µg/L in raw and fermented milk respectively for oxytetracycline while the mean residue concentration of penicillin G is 649 µg/L and 397 µg/L in raw and fermented milk respectively. However, the oxytetracycline residues detected were all below the Maximum Residue Level (MRL) standards of 100 µg/L, while the penicillin G residue detected were all above the maximum residue standard of 5 µg/L. The maximum and minimum residue for oxytetracycline detected in raw milk was 79 and 10 (µg/L) respectively while the maximum and minimum residue detected in fermented milk was 42 and 9 (µg/L) respectively. The maximum and minimum residue detected for penicillin G residue in raw milk was 1993 and 767 (µg/L) respectively while the maximum and minimum residue detected in fermented milk was 288 and 164 (µg/L). This study revealed the presence of both oxytetracycline and penicillin G residues in raw and fermented milk consumed in Maiduguri. However, oxytetracycline residues detected in this study were found to be within the acceptable limits, while the penicillin G residues were highly above the MRL standard set by CODEX.
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Wahyudi, Adefri, Fadrian e Rudy Afriant. "Warm Autoimmune Hemolytic Anemia with Chronic Hepatitis B". Sumatera Medical Journal 7, n.º 1 (1 de janeiro de 2024): 47–50. http://dx.doi.org/10.32734/sumej.v7i1.11836.
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Introduction: Warm autoimmune hemolytic anemia (wAIHA) is caused by erithrocytes destruction by IgG or IgG plus C3d-mediated autoantibody. Long use steroids are first line therapy of wAIHA. It has risk infection reactivation, like chronic hepatitis B. Case report: Man, 64 y.o, hospitalized with diagnosis wAIHA and chronic hepatitis B. Diagnosis of wAIHA is built by: severe normocytic normochromic anemia, reticulocytosis 42.29%, increasing lactate dehydrogenase 397 U/L, direct Coombs test (+4), antibody screening IgG (+4). Anothers laboratorium findings: HbsAg (+), albumin 3.5 g/dL, ALT U/L, rapid HIV (-), anti HCV (-). There is no blast found in peripheral blood and bone marrow smear. Patient also diagnosed chronic hepatitis B inactive phase with negative HbeAg, HBV DNA 547 IU/L, normal liver finding in abdominal USG and moderate fibrosis from fibroscan. Washed red cell transfussion was administered, 2 x 125 mg methilprednisolone iv (3 days) tapering off until to 40 mg/day doses. He did not get antiviral prophylaxis and be planned to reevaluate in next 6 months. Conclusion: Steroid is first line therapy in wAIHA. When wAIHA is diagnosed, determination of chronic hepatitis B status should confirmed. There is a risk of reactivation of chronic hepatitis B infection so monitoring is needed.
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Amri, Hakima, Pierre Silberzahn, Ihsan Al-Timimi e Jean-Luc Gaillard. "Aromatase activity in the mare ovary during estrous cycle. Measurement of endogenous steroids and of their in vitro inhibitory effect". Acta Endocrinologica 129, n.º 6 (dezembro de 1993): 536–42. http://dx.doi.org/10.1530/acta.0.1290536.
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This present study was undertaken to clarify estrogen synthesis in the mare ovary. First of all, an evaluation of endogenous steroid contents was carried out in the follicular fluid and in the luteal tissue at different stages of the luteal phase. Radioimmunoassays were performed after separation and purification of each hormone by chromatography. High amounts of conjugated (0.9 mg/l) and unconjugated (4 mg/l) estradiol-17β were found in the follicular fluid of the large follicules (50 mm). These concentrations of estrogens decreased drasticaly in the luteal tissue, and only low levels of circulating estrogens are found during the luteal phase. On the other hand, a high aromatization ability has been evidenced in the cyclic corpus luteum in vitro. In an attempt to clarify the regulation of estrogen synthesis, we have tested the inhibitory effect of several endogenous steroids on equine ovarian aromatase activity. 5α-Dihydrotestosterone appeared to be the most potent competitive inhibitor (Ki= 181 nmol/l) of aromatase activity, while the addition of a 3-sulfate group induced a slump in the inhibitory potency of estrone (Ki= 397 nmol/l vs 2206 nmol/l) and dehydroepiandrosterone (Ki = 291 nmol/l vs 6157 nmol/l). The physiological role of these conjugated steroids has not been known until now; we suggest that they would play a role in protecting aromatase from inhibition, in vivo. The high amounts of progesterone found in the luteal tissue (1.3 g/kg of proteins) might play a role in the regulation of estrogen production either by suppressing the induction of aromatase synthesis or by inhibiting the activity of the enzyme complex.
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Moimaz, Suzely Adas Saliba, Orlando Saliba, Fernando Yamamoto Chiba, Doris Hissako Sumida, Cléa Adas Saliba Garbin e Nemre Adas Saliba. "Fluoride concentration in public water supply: 72 months of analysis". Brazilian Dental Journal 23, n.º 4 (2012): 451–56. http://dx.doi.org/10.1590/s0103-64402012000400024.
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Known as one of the ten most important advances on Public Health in the 20th century, fluoridation of public water supply is a measure of wide population coverage, which is effective on caries control. The city of Araçatuba, in the Northwest region of the São Paulo state, Brazil, started public water supply fluoridation in 1972 and, based on the average annual highest temperature, has kept the fluoride concentration between 0.6 to 0.8 mgF/L. The purpose of this study was to analyze monthly the fluoride concentration in public water supply in the city of Araçatuba during 72 months. Water samples were collected monthly on weekdays, directly from the water distribution network, on pre-established locations and analyzed in duplicate between November 2004 and October 2010 at the Research Laboratory of the Nucleus for Public Health (NEPESCO) of the Public Health Graduate Program from Araçatuba Dental School/UNESP, Brazil, using an fluoride-specific electrode connected to an ion analyzer. From the total of samples (n=591), 67.2% (n=397) presented fluoride concentration between 0.6 and 0.8 mgF/L; 20.6% (n=122) below 0.6 mgF/L; 11.5% (n=68) between 0.8 and 1.2 mgF/L and 0.7% (n=4) above 1.2 mgF/L. Most samples showed fluoride levels within the recommended parameters. Minimal variation was observed among the analyzed collection locations, showing that the city has been able to control the fluoride levels in the public water supply and reinforcing the importance of surveillance and constant monitoring to assure the quality of the water delivered to the population.
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Jin, Mei Ling. "Approximating pointwise products of quasimodes". Forum Mathematicum 32, n.º 3 (1 de maio de 2020): 541–52. http://dx.doi.org/10.1515/forum-2019-0208.
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AbstractWe obtain approximation bounds for products of quasimodes for the Laplace–Beltrami operator on compact Riemannian manifolds of all dimensions without boundary. We approximate the products of quasimodes uv by a low-degree vector space {B_{n}}, and we prove that the size of the space {\dim(B_{n})} is small. In this paper, we first study bilinear quasimode estimates of all dimensions {d=2,3}, {d=4,5} and {d\geq 6}, respectively, to make the highest frequency disappear from the right-hand side. Furthermore, the result of the case {\lambda=\mu} of bilinear quasimode estimates improves {L^{4}} quasimodes estimates of Sogge and Zelditch in [C. D. Sogge and S. Zelditch, A note on L^{p}-norms of quasi-modes, Some Topics in Harmonic Analysis and Applications, Adv. Lect. Math. (ALM) 34, International Press, Somerville 2016, 385–397] when {d\geq 8}. And on this basis, we give approximation bounds in {H^{-1}}-norm. We also prove approximation bounds for the products of quasimodes in {L^{2}}-norm using the results of {L^{p}}-estimates for quasimodes in [M. Blair, Y. Sire and C. D. Sogge, Quasimode, eigenfunction and spectral projection bounds for Schrodinger operators on manifolds with critically singular potentials, preprint 2019, https://arxiv.org/abs/1904.09665]. We extend the results of Lu and Steinerberger in [J. F. Lu and S. Steinerberger, On pointwise products of elliptic eigenfunctions, preprint 2018, https://arxiv.org/abs/1810.01024v2] to quasimodes.
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Gauslaa, Yngvar, e Knut Asbjørn Solhaug. "High-Light-Intensity Damage to the Foliose Lichen Lobaria Pulmonaria within Natural Forest: The Applicability of Chlorophyll Fluorescence Methods". Lichenologist 32, n.º 3 (maio de 2000): 271–89. http://dx.doi.org/10.1006/lich.1999.0265.
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AbstractThe annual course of irradiance was recorded at two vertical and even-aged neighbouring Quercus stems, one rich in L. pulmonaria, one without. Irradiance never exceeded 610 μmol photons m−2 s−1 at the L. pulmonaria site, whereas the L. pulmonaria-deficient site could experience 2 h daily 2000 μmol photons m−2 s−1, and 6 h above 1000 μmol photons m−2 s−1 during a clear day in early spring. Thalli of L. pulmonaria were transplanted to these two stems. During the first 40 days (April–May), transplants at the L. pulmonaria-deficient site developed severe chlorophyll degradation, and a substantial reduction in maximal PS II efficiency (Fv/Fm) even when measured after a 48-h recovery period at low light intensity. Extensive bleaching was formed along light-exposed sides of the tiny ridges on the upper side. Subsequent to this damage, FV/FM gradually rose to nearly normal levels during the following year. This apparent recovery was probably mainly due to irreversible loss of damaged chlorophyll, but also to some level of acclimation. No damage was observed in control transplants on the L. pulmonariarich tree, which were the only transplants gaining sufficient growth for new attachment to the new substratum during the 397-day transplantation period. Nevertheless, a fine-scale, but highly significant seasonal variation in FV/FM of control transplants reflected variations of even low irradiance levels. FV/FM, as measured after a 48-h recovery period at low light intensity, is an efficient meth for recording permanent high light damages at and shortly after damage is formed. However, FV/FM is not a useful estimator of chronic long-term damage.
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SHEU, SEN-JE, WEN-ZHE HWANG, HSIN-CHIH CHEN, YU-CHENG CHIANG e HAU-YANG TSEN. "Development and Use of tuf Gene–Based Primers for the Multiplex PCR Detection of Lactobacillus acidophilus, Lactobacillus casei Group, Lactobacillus delbrueckii, and Bifidobacterium longum in Commercial Dairy Products". Journal of Food Protection 72, n.º 1 (1 de janeiro de 2009): 93–100. http://dx.doi.org/10.4315/0362-028x-72.1.93.
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PCR primers specific for the detection of Lactobacillus acidophilus, Lactobacillus casei group, Lactobacillus delbrueckii, and Bifidobacterium longum were designed based on the elongation factor Tu gene (tuf). The specificity of these four primer sets were confirmed by PCR with 88 bacterial strains of Lactobacillus, Enterococcus, Bifidobacterium, and other bacterial species. Results indicated that these primer sets generated predicted PCR products of 397, 230, 202, and 161 bp for L. acidophilus, L. delbrueckii, L. casei group, and B. longum, respectively. Bacterial species other than the target organisms tested did not generate false-positive results. When these four primer sets were combined for the simultaneous detection of the lactic acid bacteria (LAB) in fermented milk products including yogurt, the LAB species listed on the labels of these products could be identified without the preenrichment step. The identification limit for each LAB strain with this multiplex PCR method was N × 103 CFU/ml in milk samples. The results of our multiplex PCR method were confirmed by PCR assay using primers based on the 16S rDNA or the 16S–23S intergenic spacer region and by biochemical tests using the API 50 CHL kit. When this multiplex PCR method was used with the determination of counts of total viable LAB and bifidobacteria, the quality of commercial fermented milk products could be assured.
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Thomas, E. C., e L. M. (Les) Lavkulich. "Community considerations for quinoa production in the urban environment". Canadian Journal of Plant Science 95, n.º 2 (março de 2015): 397–404. http://dx.doi.org/10.4141/cjps-2014-228.
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Thomas, E. C. and Lavkulich, L. M. 2015. Community considerations for quinoa production in the urban environment. Can. J. Plant Sci. 95: 397–404. Production of food crops in urban settings is an increasingly consumer-accepted means of contributing to local food security and access to fresh produce. Many urban gardens are located on former industrial sites (brownfields) that may be contaminated by heavy metals. Growing crops in trace metal contaminated soil can pose human health concerns. Little has been documented on the uptake of metals from urban sites by crops, and especially the partitioning of metals between roots, shoots and seeds. Human health impacts are of particular concern when locally grown produce constitutes a major proportion of the local diet. The results of this study show that quinoa grown on brownfield sites in Vancouver, Canada may contain elevated levels of metals such as Cd, Cu and Pb.
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Serour, Natacha, Mickael Jury, Julie Pironom e Marie-Christine Toczek-Capelle. "Les élèves de Segpa et les collégiens en grande difficulté scolaire sont-ils perçus différemment ? Étude du contenu du stéréotype". La nouvelle revue - Éducation et société inclusives N° 96, n.º 4 (24 de agosto de 2023): 205–31. http://dx.doi.org/10.3917/nresi.096.0205.
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Au collège, la singularité des classes de Segpa pourrait favoriser l’identification des élèves de ces sections comme un groupe particulier de collégiens en Grande difficulté scolaire (GDS) auquel seraient rattachés des stéréotypes bien spécifiques. Cette recherche vise particulièrement à mettre en évidence le contenu du stéréotype des « élèves de Segpa », puis d’examiner dans quelle mesure celui-ci diffère du groupe des « collégiens en GDS ». Ces contenus sont étudiés selon deux méthodes complémentaires, l’association libre (étude 1, N = 397) et le ratio diagnostic (étude 2, N = 217). Nos résultats indiquent que si un grand nombre d’attributs sont communs entre le groupe générique des « collégiens en GDS » et sa sous-catégorie des « élèves de Segpa » des différences existent entre les deux confirmant ainsi que ces derniers seraient perçus comme une catégorie particulière de collégiens en GDS.
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Wagenius, Gunnar, Anders Vikström, Anders Berglund, Stina Salomonsson, Goran Bencina, Xiaohan Hu, Dana Chirovsky e Hans Brunnström. "First-line Treatment Patterns and Outcomes in Advanced Non-Small Cell Lung Cancer in Sweden: A Population-based Real-world Study with Focus on Immunotherapy". Acta Oncologica 63 (21 de abril de 2024): 198–205. http://dx.doi.org/10.2340/1651-226x.2024.20309.
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Background and purpose: The treatment landscape for patients with advanced non-small cell lung cancer (NSCLC) has evolved significantly since the introduction of immunotherapies. We here describe PD-L1 testing rates, treatment patterns, and real-world outcomes for PD-(L)1 inhibitors in Sweden. Materials and methods: Data were obtained from the Swedish National Lung Cancer Registry for patients with advanced NSCLC and Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0–2 who initiated first-line systemic treatment from 01 April 2017 to 30 June 2020. PD-L1 testing was available in the registry from 01 January 2018. Kaplan-Meier was used for overall survival (OS) by type treatment and histology. Results: A total of 2,204 patients with pathologically confirmed unresectable stage IIIB/C or IV NSCLC initiated first-line treatment, 1,807 (82%) with nonsquamous (NSQ) and 397 (18%) with SQ. Eighty-six per cent (NSQ) or 85% (SQ) had been tested for PD-L1 expression, a proportion that increased over time. The use of platinum-based therapy as first-line treatment decreased substantially over time while there was an upward trend for PD-(L)1-based therapy. Among patients with PS 0–1 initiating a first-line PD-(L)1 inhibitor monotherapy, the median OS was 18.6 and 13.3 months for NSQ and SQ NSCLC patients, respectively, while for the PD-(L)1 inhibitor and chemotherapy combination regimen, the median OS was 24.0 months for NSQ and not evaluable for SQ patients. Interpretation: The majority of advanced NSCLCs in Sweden were tested for PD-L1 expression. Real-world OS in patients with PS 0–1 receiving first-line PD-(L)1 inhibitor-based regimens was similar to what has been reported in pivotal clinical trials on PD-(L)1 inhibitors.
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Bhuiyan, Mohammad Azmal Hossain, SAM Shariar Islam, Abu Kowser, Md Rasikul Islam, Shahina Akter Kakoly, Khandoker Asaduzzaman e Moniruzzaman Khondker. "Phytoplankton in relation to water quality of Tanguar Haor ecosystem, Bangladesh: I. Rauar station". Dhaka University Journal of Biological Sciences 28, n.º 2 (30 de junho de 2019): 131–38. http://dx.doi.org/10.3329/dujbs.v28i2.46499.
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The water quality at Rauar station of Tanguar Haor, Sunamganj was assessed studying phytoplankton and associated environmental variables. The environmental variables were monitored over a period of one year, collecting samples at two months interval between March, 2017 and March, 2018. Air temperature, rainfall, and humidity ranged from 22.6 - 32.1°C, 48 - 76% and 8 - 930 mm, respectively. Air temperature showed a direct relationship with water temperature which varied from 22.4 - 31.0°C during the study period. The water transparency remained relatively constant throughout the year having a mean Secchi depth (Zs) value of 2.48 m. Total dissolved solids (TDS), conductivity, and pH of the water ranged from 51 - 85 mg/l, 60 - 110 μS/cm, and 7.2 - 9.7, respectively. In December, because of a temperature fall, the dissolved oxygen (DO) concentration of the water reached its maximum value of 6.09 mg/l. In the rest of the period, the concentration remained between 2.44 and 4.80 mg/l. The value of alkalinity ranged from 0.43 - 1.35 meq/l. Among the nutrients, soluble reactive phosphorus (SRP), soluble reactive silicate (SRS), and NO3-N ranged from 5.43 - 36.43 μg/l, 4 - 14.58 mg/l, and 0.06 - 0.31 mg/l, respectively. The concentration of NH4+ ranged from 238 - 1230 μg/l. The highest concentrations (905 and 1230 μg/l) occurred between September and December, 2017. This might be attributed to the higher density of migratory birds during that period. The phytoplanktonic biomass expressed as chlorophyll-a (Chl-a) ranged from 1.35 - 8.45 μg/l while its degraded product phaeophytin concentration ranged from 0.08 - 3.5 μg/l. The standing crop of phytoplankton ranged from 397 - 2480 × 103 individuals/l of haor water exhibiting its maximum abundance in September. This parameter showed a highly significant positive correlation with SRP. From the correlation analysis, the degradation of chl-a to phaeophytin was found to be temperature dependent. Considering the different physicochemical and biological water quality data, it could be said that the Tanguar Haor is still free from organic pollution. However, the range of soluble reactive phosphorus data (5.43 - 36.43 μg/l) show that the Haor has been passing a meso-eutrophic state.
Dhaka Univ. J. Biol. Sci. 28(2): 131-138, 2019 (July)
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Lumsden, Robert D. "Plant Diseases: Their Biology and Social Impact. 1991. By Gail L. Schumann. American Phytopathological Society, St. Paul, Minnesota. 397 pp. $45.00, hardbound." American Journal of Alternative Agriculture 6, n.º 4 (dezembro de 1991): 188–89. http://dx.doi.org/10.1017/s0889189300004252.
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King, D. M. "Book reviewsDiagnostic Imaging: An Algorithmic Approach. Ed. by EisenbergRonald L., pp. xx + 713, 1987 (Lippincott, Philadelphia), £79.50. ISBN 0–397–58300–1". British Journal of Radiology 62, n.º 736 (abril de 1989): 398. http://dx.doi.org/10.1259/0007-1285-62-736-398-b.
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Li, Yandie, Jianghan Wang, Tong Wang, Zhuoxia Lv, Linting Liu, Yuping Wang, Xu Li, Zhexin Fan e Baokun Li. "Differences between Kazak Cheeses Fermented by Single and Mixed Strains Using Untargeted Metabolomics". Foods 11, n.º 7 (26 de março de 2022): 966. http://dx.doi.org/10.3390/foods11070966.
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Mixed fermentation improves the flavor quality of food. Untargeted metabolomics were used to evaluate the impact of mixed fermentation and single-strain fermentation on the volatile and non-volatile compound profiles of Kazak cheese. Lacticaseibacillus paracasei SMN-LBK and Kluyveromyces marxianus SMN-S7-LBK were used to make mixed-fermentation cheese (M), while L. paracasei SMN-LBK was applied in single-strain-fermentation cheese (S). A higher abundances of acids, alcohols, and esters were produced via mixed fermentation. Furthermore, 397 differentially expressed non-volatile metabolites were identified between S and M during ripening. The flavor compounds in mixed-fermentation cheese mainly resulted from ester production (ethyl butanoate, ethyl acetate, ethyl octanoate, and ethyl hexanoate) and amino acid biosynthesis (Asp, Glu, Gln, and Phe). The metabolites were differentially expressed in nitrogen metabolism, D-glutamine and D-glutamate metabolism, phenylalanine metabolism, D-alanine metabolism, and other metabolic pathways. The amount of flavor compounds was increased in M, indicating that L. paracasei SMN- LBK and K. marxianus SMN-S7-LBK had synergistic effects in the formation of flavor compounds. This study comprehensively demonstrated the difference in metabolites between mixed-fermentation and single-strain-fermentation cheese and provided a basis for the production of Kazak cheese with diverse flavor characteristics.
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Van de Wouw, A. P., J. L. Scanlan, S. J. Marcroft, A. J. Smith, E. M. Sheedy, N. W. Perndt, C. E. Harrison, L. M. Forsyth e A. Idnurm. "Fungicide sensitivity and resistance in the blackleg fungus, Leptosphaeria maculans, across canola growing regions in Australia". Crop and Pasture Science 72, n.º 12 (2021): 994. http://dx.doi.org/10.1071/cp21369.
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Fungicide use has become a fundamental part of many crop protection systems around the world, including to control blackleg disease on canola (Brassica napus L.). In Australia, most canola growers routinely apply at least one fungicide, and potentially multiple fungicides with different modes of action, in a single growing season. There is evidence for the emergence of fungicide resistance in Leptosphaeria maculans, the causal agent of blackleg disease, to the demethylation inhibitor (DMI) class of fungicides in Australia. However, it is not known whether resistance exists towards other chemical classes such as the succinate dehydrogenase inhibitors (SDHI). In this work, 397 samples were screened for resistance towards seven fungicide treatments in stubble-borne L. maculans populations collected from eight canola-growing agro-ecological regions of Australia from 2018 to 2020, a time frame that bridges the introduction of new chemicals for blackleg control. We confirmed that DMI resistance in L. maculans is pervasive across all of the sampled canola-growing regions, with 15% of fungal populations displaying high levels (resistance scores >0.5) of resistance towards the DMI fungicides. Although resistance to newly introduced SDHI fungicides was low, we found evidence of positive cross-resistance between established DMI-only fungicides and a newly introduced combined DMI and quinone outside inhibitor fungicide, suggesting that the efficacy of the latter may be limited by widespread DMI resistance. Proactive surveillance, as performed here, may provide a means to avoid the rapid loss of fungicide efficacy in the field.
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Павлючик, Е. Н., А. Д. Капсамун e Н. Н. Иванова. "The adaptive potential of the promising varieties of legumes and gramineous on the drained lands of the Tver region". Кормопроизводство, n.º 6.2023 (25 de setembro de 2023): 3–7. http://dx.doi.org/10.25685/krm.2023.6.2023.008.
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В статье изложены результаты исследований адаптивности к почвенно-климатическим условиям Тверской области бобово-злаковых травосмесей на основе клевера лугового (Trifolium pratense L.), люцерны изменчивой (Medicago x varia Arcang.) и злаковых трав — тимофеевки луговой (Phleum pratense L.) и овсяницы луговой (Festuca pratensis L.). Исследования проводились в 2018‒2022 годах. Выявлено, что благодаря адаптации к агроклиматическим и почвенно-мелиоративным условиям осушаемых земель смешанные травостои в первые 2 года пользования формировали урожай кормовой массы за счёт активного роста клевера лугового и злаковых компонентов: 9,2‒11,1 т/га сухой массы — в смеси с тимофеевкой луговой и 7,8‒9,7 т/га — с овсяницей луговой. При использовании травосмесей 3‒4-го годов пользования в период, когда клевер луговой выпал из травостоя, урожай сухой массы трав формировался с активным участием более долголетней бобовой культуры —люцерны изменчивой: в смеси с тимофеевкой луговой — 5,3‒8,5 т/га и 6,2‒7,8 т/га — в смеси с овсяницей луговой. При ранней тёплой весне 2019‒2020 годов наибольшая урожайность получена у смесей с ранними сортами клевера лугового Грин, Кретуновский и Шанс — 8,7‒10,6 т/га. При засушливых условиях в первой половине вегетации и благоприятных во второй наибольшая урожайность получена у смеси с поздним сортом клевера Фаленский 86 — 10,6 т/га. Травосмеси с участием тимофеевки луговой за годы исследований отличались большей урожайностью (8,7 т/га) при плотности травостоя 378‒440 шт./м2, чем смеси с овсяницей луговой (8,2 т/га) при интенсивности побегообразования 364‒397 шт./м2. В среднем по сумме двух укосов среди исследуемых сортов клевера лугового наименее урожайными в условиях изменяющегося климата были травосмеси с клевером луговым сорта Грин —8,0 т/га. У сравниваемых сортов клевера сбор сухого вещества составил 8,4‒8,6 т/га в трёхкомпонентных травосмесях. This article reports on the adaptive potential of the mixtures of red clover (Trifolium pratense L.), bastard alfalfa (Medicago x varia Arcang.), common timothy (Phleum pratense L.) and meadow fescue (Festuca pratensis L.) in the environment of the Tver region in 2018‒2022. Due to the resistance of the crops to the climate and soil conditions of drained lands and active growth of red clover and gramineous the mixtures with common timothy or meadow fescue formed, respectively, 9.2‒11.1 t ha-1 and 7.8‒9.7 t ha-1 of dry mass in the first 2 years. The 3‒4-year old ecosystems lacking red clover yielded 5.3‒8.5 t ha-1 and 6.2‒7.8 t ha-1 of dry mass, respectively, due to the long-standing bastard alfalfa. Early warm spring of 2019‒2020 led to the highest productivity of the mixtures with such short-season varieties of red clover as “Grin”, “Kretunovskiy” and “Shans” —8.7‒10.6 t ha-1. Dry conditions of the first period of the growing season and its favorable second part provided the highest yield of 10.6 t ha-1 for the mixture with long-season clover “Falenskiy 86”. The ecosystems with common timothy had higher productivity (8.7 t ha-1) under the stand density of 378‒440 pcs/m2 as compared to the meadow fescue mixtures (8.2 t ha-1) under the shoot-formation intensity of 364‒397 pcs/m2. The stands with “Grin” showed the lowest productivity — 8.0 t ha-1 for two cuts. Red clover yielded 8.4‒8.6 t ha-1 of dry matter in three-component mixtures.
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Chen, Xiaoling, Jianru Feng, Huaqian Mou, Zheng Liang, Tianzheng Ding, Shiyu Chen e Feili Li. "Utilization of Indole Acetic Acid with Leucadendron rubrum and Rhododendron pulchrum for the Phytoremediation of Heavy Metals in the Artificial Soil Made of Municipal Sewage Sludge". Toxics 11, n.º 1 (31 de dezembro de 2022): 43. http://dx.doi.org/10.3390/toxics11010043.
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The development of phytoremediation by garden plants is an effective way to deal with the dilemma of municipal sewage sludge disposal. In this study, two ornamental plants were used as phytoremediation plants to rehabilitate heavy-metal-contaminated municipal sewage sludge in field experiments, and the role of exogenous phytohormone IAA was also tested. Ornamental plants Loropetalum chinense var. rubrum (L. rubrum) and Rhododendron pulchrum (R. pulchrum) adapted well to the artificial soil made of municipal sewage sludge, and the concentrations of Cu, Zn, Pb, and Ni were decreased by 7.29, 261, 20.2, and 11.9 mg kg−1, respectively, in the soil planted with L. rubrum, and 7.60, 308, 50.1, and 17.7 mg kg−1, respectively, in the soil planted with R. pulchrum, accounted for 11–37% of the total amounts and reached significant levels (p < 0.05), except Cd. The concentration of Pb in all parts of the two ornamental plants was increased, as well as most heavy metals in L. rubrum root. As a result, three months after transplant, the phyto-extraction amounts in L. rubrum were 397, 10.9, and 1330 μg for Ni, Cd, and Pb, respectively, increased by 233% to 279%. The phyto-extraction amount in R. pulchrum were 1510, 250, and 237 μg for Zn, Pb, and Cu, respectively, increased by 143% to 193%. These results indicated a potential to remediate heavy metals of the two ornamental plants, especially L. rubrum. The results of correlation analysis implied that the interaction of heavy metals in the plant itself played an important role in the uptake of heavy metals. This seemed to explain why applying IAA in the experiment had little effect on plant growth and phytoremediation of heavy metals. This study provided a green and feasible idea for the proper disposal of municipal sewage sludge.
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Atley, L. M., N. Lefroy e J. D. Wark. "1,25-Dihydroxyvitamin D3-induced upregulation of the thyrotropin-releasing hormone receptor in clonal rat pituitary GH3 cells". Journal of Endocrinology 147, n.º 3 (dezembro de 1995): 397–404. http://dx.doi.org/10.1677/joe.0.1470397.
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Abstract 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) is active in primary dispersed and clonal pituitary cells where it stimulates pituitary hormone production and agonist-induced hormone release. We have studied the effect of 1,25-(OH)2D3 on thyrotropin-releasing hormone (TRH) binding in clonal rat pituitary tumour (GH3) cells. Compared with vehicle-treated cells, 1,25-(OH)2D3 (10 nmol/l) increased specific [3H]MeTRH binding by 26% at 8 h, 38% at 16 h, 35% at 24 h and reached a maximum at 48 h (90%). In dose–response experiments, specific [3H]MeTRH binding increased with 1,25-(OH)2D3 concentration and reached a maximum at 10 nmol/l. Half-maximal binding occurred at 0·5 nmol 1,25-(OH)2D3/l. The vitamin D metabolite, 25-OH D3, increased [3H]MeTRH binding but was 1000-fold less potent than 1,25-(OH)2D3. In equilibrium binding assays, treatment with 10 nmol 1,25-(OH)2D3/l for 48 h increased the maximum binding from 67·4 ± 8·8 fmol/mg protein in vehicle-treated cells to 96·7 ± 12·4 fmol/mg protein in treated cells. There was no difference in apparent Kd (1·08 ± 0·10 nmol/l for 1,25-(OH)2D3-treated and 0·97 ± 0·11 nmol/l for vehicle-treated cells). Molecular investigations revealed that 10 nmol 1,25-(OH)2D3/l for 24 h caused an 8-fold increase in TRH receptor-specific mRNA. Actinomycin D (2 μg/ml, 6 h) abrogated the 1,25-(OH)2D3-induced increase in [3H]MeTRH binding. Cortisol also increased [3H]MeTRH binding but showed no additivity or synergism with 1,25-(OH)2D3. TRH-stimulated prolactin release was not enhanced by 1,25-(OH)2D3. We conclude that the active vitamin D metabolite, 1,25-(OH)2D3, caused a time- and dose-dependent increase in [3H]MeTRH binding. The effect was vitamin D metabolite-specific and resulted from an upregulation of the TRH receptor. Further studies are needed to determine the functional significance of this novel finding. Journal of Endocrinology (1995) 147, 397–404
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Khan, Dilshad Ahmed, Shahida Mushtaq, Farooq Ahmad Khan e Muhammad Qaiser Alam Khan. "Toxic effects of chromium on tannery workers at Sialkot (Pakistan)". Toxicology and Industrial Health 29, n.º 2 (18 de janeiro de 2012): 209–15. http://dx.doi.org/10.1177/0748233711430974.
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Chromium is widely used in the leather industry, and tannery workers are under constant threat of adverse health effects due to its excessive exposure. Our objective was to find out the toxic effects of chromium on tannery workers at Sialkot, Pakistan. A total of 240 males consisting of 120 workers from tanneries at Sialkot and equal number of controls were included. Blood complete counts, high-sensitive C-reactive protein, malondialdehyde and routine biochemical tests were carried out by routine procedures. Chromium levels in blood (BCr) and urine were analyzed using graphite furnace atomic absorption spectrophotometer Perkin Elmer analyst-200. Results revealed that all the workers were male with average age of 33 years and 15 (13%) had skin rashes, 14 (12%) had chronic bronchitis, 10 (8%) had gastritis and 4 (3%) conjunctivitis. The tannery workers had significantly raised median (interquartile range) of BCr 569 (377–726) nmol/L as compared to 318 (245–397) nmol/L in the control ( p < 0.001). Sixty-five (54%) workers had BCr levels above the upper limit set by Agency for Toxic Substance and Drug Registry. The urinary chromium excretion was significantly high in workers 131 (46–312) nmol/L as compared to 13 (3–26) nmol/L in controls ( p < 0.01). The workers had hematological, hepatic and renal function impairment because of oxidative stress on body systems. It is concluded that about half of the workers had excessive exposure to chromium in the tanneries at Sialkot. They had significantly raised chromium levels in their biological fluids and adverse health effects due to enhanced oxidative stress and inflammatory changes.