Artigos de revistas: "Kulakov"

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Lichterman, Boleslav. "Vladimir Ivanovich Kulakov". BMJ 334, n.º 7605 (7 de junho de 2007): 1226. http://dx.doi.org/10.1136/bmj.39224.617106.be.

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-. "KULAKOV YURY IVANOVITCH (1927-2019)". Metafizika, n.º 1 (15 de dezembro de 2020): 141–46. http://dx.doi.org/10.22363/2224-7580-2020-1-141-146.

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Neshchadim, M. V., e A. A. Simonov. "Kulakov Algebraic Systems on Groups". Siberian Mathematical Journal 62, n.º 6 (novembro de 2021): 1100–1109. http://dx.doi.org/10.1134/s0037446621060112.

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Neshchadim, M. V., e A. A. Simonov. "Kulakov algebraic systems on groups". Sibirskii matematicheskii zhurnal 62, n.º 6 (30 de outubro de 2021): 1357–68. http://dx.doi.org/10.33048/smzh.2021.62.611.

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Neshchadim, M. V., e A. A. Simonov. "Identities and $$n$$-Ary Kulakov Algebras". Siberian Advances in Mathematics 33, n.º 2 (25 de maio de 2023): 140–50. http://dx.doi.org/10.1134/s1055134423020037.

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Khudokormov, Alexandr. "Review of a Textbook “Economic Development. Theory and Practice”". Moscow University Economics Bulletin 2017, n.º 3 (30 de junho de 2017): 150–56. http://dx.doi.org/10.38050/01300105201738.

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Saparov, D. D. "Engineer of a communications A.N. Kulakov as outstanding experts in the field of construction and restoration of railways". Belgorod State University Scientific bulletin. Series: History. Political science 46, n.º 4 (30 de dezembro de 2019): 682–96. http://dx.doi.org/10.18413/2075-4458-2019-46-4-682-696.

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The article is devoted to one of the most interesting personalities in the history of Russian railways – railway engineer Alexander Nikolaevich Kulakov (1875–1928), a prominent specialist in the field of construction and rehabilitation of railways. From 1898 to 1918, he worked on the Nikolaev, Chinese-Eastern, Ryazan-Ural, Warsaw-Vienna, Podolsk, South-Western railways, having gained vast experience in the field of restructuring, construction, restoration of the road and artificial structures in the Russian-Japanese, World War I and the Civil War. The personality of the railway engineer Kulakov is an example of courage and loyalty to his profession in Yugoslavia, where he was forced to emigrate after the end of the Civil War in Russia. The author analyzes the surviving documents of the personal fund transferred to the Central Museum of Railway Transport of Russia and archival materials of the Russian State Historical Archive, on the basis of which the biographical article was prepared.

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Antipenko, L. G. "A FEW REMARKS ON THE CONCEPT OF PREGEOMETRY DEVELOPED BY YU.S. VLADIMIROV AND LAID BY HIM THE BASIS OF IDEAS ABOUT THE PHYSICAL AND MATHEMATICAL STRUCTURE OF SPACE-TIME". Metafizika, n.º 2 (15 de dezembro de 2020): 117–24. http://dx.doi.org/10.22363/2224-7580-2020-2-117-124.

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In the program of physical research, formulated by Yu.S. Vladimirov and close to those tasks that are called the geometrization of physics, the author presents an original view on the creative process in physics, which began with the concept of physical structures of Yu.I. Kulakov. Vladimirov used Kulakov’s meta- physical concept to create a geometric image of the world in order to move from it to the study of the structure of space-time with subsequent filling it with physical content. The result is a relational theory of space-time, which is based on axiomatic called pregeometry. In this article, this axiomatics is subjected to critical reflection, its positive and negative points are noted. Among the shortcomings, the author of the Remarks refers a one-sided approach to the concept of physical interaction, where any effect or influence of one physical object on another seems to be long-range in the sense that the action is transmitted without any intermediary and at infinite speed. Another point of view: long-range action should be supplemented by short-range action, because these are two necessary aspects of physical reality. The idea of complementarity of 1. Bohr extends to them: contraria sunt complementa (opposites are complementary).

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Kulakov, N. A., A. N. Lyubin e A. S. Skakbaeva. "Numerical and experimental stufy of composite ceramic armor resistance when exposed to high-speed bullets and fragments". Izvestiya MGTU MAMI 6, n.º 2-1 (20 de janeiro de 2012): 206–13. http://dx.doi.org/10.17816/2074-0530-68496.

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+7(495)223-05-23 ext. 1507, kulakov@mami.ru The article presents the results of calculation and experimental study of a composite ceramic armor resistance when exposed to high-speed bullets and fragments. Based on the analysis of the experiments the authors refined a finite-element model, which allowed to make multiple calculations of various structural designs of armor in order to choose the most rational. Authors show influence of geometrical parameters of a ceramic element on the strength of armor.

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Shumakova, O. V., N. Ya Morozova, A. A. Burov, Yu L. Podurovskaya, E. L. Bockeriya, I. E. Nefedova, D. O. Berishvily e D. N. Degtyarev. "Peculiarities of hemostasis in infants with congenital heart diseases in the first 12 hours of their life". Pediatric Hematology/Oncology and Immunopathology 18, n.º 3 (13 de setembro de 2019): 29–34. http://dx.doi.org/10.24287/1726-1708-2019-18-3-29-34.

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The article is focused on the main parameters hemostasis and platelet count of newborns with congenital heart diseases who could require an early cardiac surgery during the first 12 hours of their life. Some known disorders of hemostasis in children with congenital heart diseases are described. A clinical case of the thrombotic complications in the child after cardiac surgery are presented, the tactic of drug therapy is described. The study was approved by the Independent Ethics Committee of the V.I. Kulakov Obstetrics, Gynecology and Perinatology Research Centre.

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Prilepskaya, Vera N. ""The memory that warms the hearts" Academician Vladimir I. Kulakov (on his 85th birthday)". Gynecology 24, n.º 4 (29 de setembro de 2022): 236–39. http://dx.doi.org/10.26442/20795696.2022.4.201835.

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Petoukhov, S. V. "GENETIC BASIS OF ALGEBRAIC BIOLOGY, GESTALT GENETICS AND TETRA-EIDOSES BY Yu. I. KULAKOV". Metaphysics, n.º 2 (15 de dezembro de 2021): 65–83. http://dx.doi.org/10.22363/2224-7580-2021-2-65-83.

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The article is devoted to the universal algebraic rules of nucleotide sequences in the DNA of genomes of higher and lower organisms. The patterns identified by the author are related to the known binary nature of genetic structures and are expressed in genomic gestalt phenomena, which are similar to genetically inherited phenomena of gestalt psychology. This allows the author to develop the ideas of gestalt genetics and algebraic biology. Many genetic phenomena of tetrastructurization evoke associations with Kulakov’s concept of tetra-eidoses.

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Vladimirov, Yu S. "PRINCIPLES OF METAPHYSICS IN THE THEORY OF PHYSICAL STRUCTURES AND IN THE META-RELATIONAL PARADIGM". Metaphysics, n.º 4 (15 de dezembro de 2023): 19–40. http://dx.doi.org/10.22363/2224-7580-2023-4-19-40.

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In the work indicated are, firstly, three main reasons for revision of prevailing ideas about physical reality: inadequacy of the classical space-time in microworld physics, unsuccessful attempts to combine the principles of quantum theory and general relativity and, above all, the presence of the third physical paradigm - relational one. Secondly, shown are the constituents of the latter requiring the use of key metaphysical principles, and thirdly, they have been formulated. Fourthly, the mathematical formalism reflecting the unity of three metaphysical principles has now been proposed. Its foundations were laid in the theories of physical structures by Yu.I. Kulakov et al. Finally, fifthly, shown are basic results of applying the theory of binary systems of complex relations to solve the problems of microworld physics.

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Lobchenko, Liudmila. "Dekulakisation and resettlement of former kulaks to the north of European Russia: a historiographic aspect". OOO "Zhurnal "Voprosy Istorii" 2021, n.º 04-1 (1 de abril de 2021): 134–43. http://dx.doi.org/10.31166/voprosyistorii202104statyi10.

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The historiographic overview discusses academic views on dekulakisation and resettlement of former kulaks in different periods of Soviet history, from the 1930s to the 1990s. Special attention is paid to seminal academic works detailing various aspects of class struggle in the USSR and the ‘elimination of kulaks as a class’ as well as to the labour education and lives of former kulaks. The article cites facts accepted by most historians and details of collectivisation and its consequences. It also discusses points that remain controversial in the historical science to this day and provides alternative opinions from the course of Soviet history on dekulakisation and special settlements for former kulaks.

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Naberezhnev, Yu I., N. K. Tetruashvili, A. I. Gus, A. A. Burov, M. G. Shneiderman, V. A. Klimov e R. G. Shmakov. "Retrospective Analysis of the Results of Diagnosis and Treatment of Congenital Diaphragmatic Hernia of the Fetus According to the Perinatal Consultation". Doctor.Ru 21, n.º 5 (2022): 31–37. http://dx.doi.org/10.31550/1727-2378-2022-21-5-31-37.

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Study Objective: Analysis of the detection of congenital diaphragmatic hernia (CDH) in the fetus at the antenatal stage and perinatal outcomes of newborns with CDH in the Russian Federation in a sample of women who applied to the perinatal consultation of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov. Study Design: Retrospective study. Materials and Methods. The study included 235 cases of CDH in fetuses and newborns were selected by the federal perinatal consultation of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov. The following were retrospectively analyzed: medical and social characteristics of pregnant women, results of ultrasound and MRI examination of fetuses, delivery features and perinatal outcomes. Study Results. The number of women with fetal CDH in the perinatal consultation of the Center continues to grow every year. In 3/4 of the treated patients, fetal CDH was detected in the 2nd trimester of pregnancy, which exceeds the European level of detection. But against this background, an extremely low level of invasive prenatal diagnosis was noted. Detection using ultrasound and MRI of liver infection in the chest, including a group with a prognosis of high neonatal survival of 2.2–4 times. The perinatal mortality rate with CDH in the Centers detection is 43.4%. The most common method of delivery is the natural birth. The optimal term of delivery with the least increase in postnatal loss should be considered the period of 38–39 weeks of pregnancy. Forecast of survival of newborns. At the same time, the Apgar score does not have statistical indicators of differences in surviving and deceased newborns, regardless of the method of delivery, which is associated with a violation of child development. Conclusion. The level of detection of CDH and perinatal mortality of newborns is similar to the data of foreign perinatal centers that provide assistance to mothers and their newborns. Increasing the survival rate of newborns with CDH is possible with the development and implementation of an integrated system for diagnosing the severity of CDH, as this will open up the possibility of a personalized approach to the treatment of CDH. Keywords: congenital diaphragmatic hernia, perinatal mortality, perinatal consultation, pulmonary hypoplasia, cardiac compression.

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Kosterina, E. E., E. N. Balashova, A. M. Krasnyi, A. R. Kirtbaya, A. A. Rudakova, A. A. Sadekova, V. V. Vtorushina, L. V. Krechetova e O. V. Ionov. "Fecal cytokine profile in preterm infants in the diagnosis of necrotizing enterocolitis: pilot study results". Pediatric Hematology/Oncology and Immunopathology 23, n.º 1 (11 de janeiro de 2024): 119–26. http://dx.doi.org/10.24287/1726-1708-2024-23-1-119-126.

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In this study, we sought to determine fecal cytokine levels in very preterm newborns at the onset of non-specific clinical symptoms of necrotizing enterocolitis (NEC) and decreased gastrointestinal (GI) motility. The study was approved by the Ethics Committee and the Scientific Council of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V. I. Kulakov of Ministry of Healthcare of the Russian Federation. Each patient’s parents gave their informed consent to their child’s participation in the study. The study was conducted at the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V. I. Kulakov over the period from June 2020 to December 2022. Fecal samples from preterm neonates with gestational age ≤ 32 weeks treated at the A.G. Antonov ICU were collected daily over their first 14 days of life. Samples from 46 newborns were selected for analysis: fecal samples collected on the day of an enteral feeding intolerance episode and fecal samples from controls who had not developed non-specific clinical symptoms of NEC or decreased GI motility, collected on the day when enteral intake reached 100 ml/kg/day. Based on the results of NEC and decreased GI motility diagnosis, stool samples were retrospectively divided into 3 groups: an NEC group (n = 8), a decreased GI motility group (n = 14) and a control group (n = 24). In the fecal samples of the very preterm newborns with NEC stage ≥ II, there was a significant increase in IL-6, IL-8, IL-10, TNF-a levels at the onset of initial symptoms of the disease. At the same time, the cytokine profile of the feces of the decreased GI motility patients did not differ significantly from the control group in any of the parameters. In cases of NEC, high IL-6, IL-8, IL-10 and TNF-a levels were detected in the patients’ stool at the onset of enteral feeding intolerance, suggesting that the method under investigation (aimed at determining the pro- and anti-inflammatory profile of fecal cytokines) may be a promising new tool for differentiating NEC from decreased GI motility in very preterm newborns.

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Kazakova, A., O. Lineva, A. Mishina, E. Kulagina, A. Trupakova e I. Dufinets. "RISK FACTORS FOR ABNORMAL UTERINE BLEEDING IN THE PUBLIC PERIOD. MOLECULAR GENETIC ASPECTS". ASJ 1, n.º 48 (14 de maio de 2021): 20–23. http://dx.doi.org/10.31618/asj.2707-9864.2021.1.48.89.

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For many years, reproductive health continues to be the main state task. Its formation begins from the moment of conception and continues until the age of puberty. The reproductive health of adolescents is recognized today as one of the most acute medical and social problems and a factor of national security. Numerous studies confirm that during the formation of the reproductive system, its functions are very susceptible to adverse factors. In this regard, special attention is paid to the prevention and treatment of gynecological diseases in childhood. According to the data of preventive examinations, the frequency of gynecological pathology in the adolescent population increased by an average of 1.7 times (Uvarova E.V., Kulakov V.I., 2018). In the structure of gynecological morbidity, menstrual dysfunctions occupy the 2nd place, amounting to 7 - 17%, in turn, the frequency of AMC ranges from 10 to 37.3%. The fluctuation of such statistical values is due to the fact that not all girls turn to with uterine bleeding to provide medical care, and this problem is not always adequately assessed by the parents and the doctors observing the girl.

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Sharafutdinova, D. R., E. N. Balashova, Yu V. Kessler, I. A. Vedikhina, Yu V. Sukhova, А. R. Kirtbaya, A. Yu Ryndin, T. Yu Ivanets e O. V. Ionov. "Diagnostic significance of serum erythropoietin as a marker of perinatal brain damage in premature newborns with very low birth weight". Pediatric Hematology/Oncology and Immunopathology 22, n.º 3 (30 de setembro de 2023): 136–45. http://dx.doi.org/10.24287/1726-1708-2023-22-3-136-145.

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The search for promising markers of brain damage in premature newborns is important for the development and optimization of individual diagnostic and therapeutic approaches to neuroprotection in neonatology. Objective: to evaluate the diagnostic significance of serum erythropoietin (sEPO) on the 1st day of life as a marker of perinatal brain damage in premature infants with very low birth weight (VLBW). The study protocol was approved by the Biomedical Research Ethics Committee (Minutes No.12 of 17 November 2016) and the Scientific Council (Minutes No.19 of 29 November 2016) of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation. Written informed consent to the patients' participation in the study was obtained from their parents. The study included 47 premature infants with VLBW born in 2018 at the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Healthcare of the Russian Federation. In these patients, sEPO was determined on the 1st day of life. Depending on the level of sEPO, infants were divided into 3 groups: group 1 – premature infants with VLBW with a low sEPO level on the 1st day of life (< 20 IU/L, n = 24); group 2 – premature infants with VLBW with an average sEPO level of 20–39 IU/L (reference values) (n = 14) – control group; group 3 – premature infants with VLBW with an elevated sEPO level (≥ 40 IU/L, n = 9). We determined the frequency of brain damage, including intraventricular hemorrhages (IVH) and periventricular leukomalacia. sEPO was not correlated with gestational age. In group 1, IVH ≤ Grade II was observed in 4/24 (16.7%) infants; in group 2, IVH ≤ Grade II was observed in 3/14 (21.4%) infants, and 1/14 (7.1%) infant had IVH Grade III; in group 3, IVH ≤ Grade II was noted in 1/9 (11.1%) infant, and IVH Grade III – in 1/9 (11.1%) infant, p > 0.05. There were no cases of periventricular leukomalacia. A high sEPO level on the 1st day of life in premature infants with VLBW was not associated with an increased risk of perinatal brain damage. The clinical value and practical significance of the determination of sEPO on the 1st day of life as a marker of perinatal brain damage in premature infants with VLBW did not demonstrate any benefits. Further studies are required to assess the role of sEPO in predicting neonatal outcomes.

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Young, Eddie H. "Book Rvw: Acousto-Optic Signal Processing: Fundamentals & Applications. By Pankaj F. Das, Casimer DeCusatis, and Sergey V. Kulakov". Optical Engineering 31, n.º 02 (1 de fevereiro de 1992): 373. http://dx.doi.org/10.1117/1.oe.31.4.bkrvw2.

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Sharafutdinova, D. R., E. N. Balashova, А. R. Kirtbaya, A. Yu Ryndin, J. M. Golubtsova e O. V. Ionov. "The effectiveness of umbilical cord milking/ delayed cord clamping and recombinant human erythropoietin in reducing red blood cell transfusions in extremely and very low birth weight infants". Pediatric Hematology/Oncology and Immunopathology 20, n.º 3 (8 de outubro de 2021): 36–45. http://dx.doi.org/10.24287/1726-1708-2021-20-3-36-45.

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Anemia of prematurity is one of the most common and serious problems of neonatology. The main focus is to prevent of anemia in preterm infants. The aim of the study was to assess effectiveness of umbilical cord milking/delayed cord clamping and erythropoietin therapy in reducing red blood cell transfusions in extremely and very low birth weight infants. This clinical study was approved by the Commission on ethics of biomedical research (Protocol No. 12 November 17, 2016) and approved by the Scientific Council of National Medical Research Center for obstetrics, gynecology and perinatology named academician V.I. Kulakov of the ministry of Healthcare of the Russian Federation (Protocol No. 19 of November 29, 2016). Analysis of 482 extremely and very low birth weight infants was conducted (from 2008 to 2018). Umbilical cord milking or delayed umbilical cord clamping, both, and in combination with recombinant human erythropoietin therapy, decreasing the phlebotomy losses significantly reduces the need for transfusions of red blood cells in extremely and very low birth weight infants. The effectiveness of erythropoietin therapy, time of its start and various treatment schemes remain controversial, therefore further researches are necessary.

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Kostyukov, K. V., K. A. Gladkova, V. A. Sakalo, R. G. Shmakov, N. K. Tetruashvili e A. I. Gus. "Fetal Medicine: Literature Review and the Experience of V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynaecology and Perinatal Medicine". Doctor.Ru 166, n.º 11 (2019): 35–43. http://dx.doi.org/10.31550/1727-2378-2019-166-11-35-43.

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Sharafutdinova, D. R., E. N. Balashova, Yu V. Kessler, Yu V. Sukhova, A. R. Kirtbaya, А. Yu Ryndin, T. Yu Ivanets e O. V. Ionov. "Reticulocyte hemoglobin content as a marker of iron deficiency in premature newborns with very low birth weight. A simple tool for diagnosing iron deficiency". Pediatric Hematology/Oncology and Immunopathology 22, n.º 3 (30 de setembro de 2023): 146–55. http://dx.doi.org/10.24287/1726-1708-2023-22-3-146-155.

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Reticulocyte hemoglobin content (RET-He) is a promising marker of iron deficiency (ID) in newborns. Objective: to determine the diagnostic value of RET-He as a marker of ID in premature newborns with very low birth weight (VLBW). We conducted a single-center retrospective cohort study, which included 66 premature infants admitted to the National Medical Research Center for Obstetrics, Gynecology and Perinatology named the Academician V.I. Kulakov of the Ministry of Healthcare of the Russian Federation. Data were obtained from January 2016 to December 2018. The gestational age ranged from 29 to 32 weeks. Laboratory examination included blood tests on the 1st and 3rd day of life, then every 10–14 days until the day of life, then every 10–14 days the Institute of Neonatology and Pediatrics; discharge from hospital, and the measurements of serum iron, ferritin, transferrin on the 7th until the discharge from hospital. This clinical study was approved by the Biomedical Research Ethics Committee (Minutes No.12 of 17 November 2016) and the Scientific Council (Minutes No.19 of 29 November 2016) of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation. RET-He was the highest at birth and declined gradually thereafter in premature newborns reaching the lowest values after 3 weeks of life (median (interquartile range) 28.4 (25.8–34.8) pg (on the 1st day of life – 40.0 (35.7–41.9) pg and 33.5 (29.2–36.6) pg at the time of discharge). A low RET-He level was associated with low reticulocytes, with no changes in hemoglobin. There was a positive correlation between RET-He and MCH. D-He decreased from 1 to 42 days of life as a marker of increasing anemia. There was a negative correlation between RET-He and Hypo-He (p < 0.005). Starting from 42 days of life, or by the time of discharge, 32% of premature infants (n = 21) had a low ferritin level and 77% (n = 51) of premature infants had a low RET-He level, of which 21 infants developed ID (a positive correlation between RET-He and ferritin after 42 days of life (r = 0.34, p = 0.046)). There was no correlation between RET-He and ferritin in newborns without ID. Also, there were no correlations between RET-He and iron and RET-He and transferrin. After 42 days of life, RET-He less than 28.4 pg was a marker of ID (sensitivity 83.3% and specificity 93.7%). Low RET-He, D-He, RBC-Hе and high microR, Hypo-He were the earliest markers of ID in premature infants which predicted a decrease in serum iron and ferritin levels. RET-He, D-Не and Hypo-He are biomarkers with accurate diagnostic value of ID in premature infants with VLBW.

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Lobchenko, Liudmila. "Special settlement of “former kulaks” from the North Caucasus to northern regions of the country in the 1930s". OOO "Zhurnal "Voprosy Istorii" 2019, n.º 12_2 (1 de dezembro de 2019): 125–31. http://dx.doi.org/10.31166/voprosyistorii201912statyi35.

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Batyrova, Zalina K., Zaira K. Kumykova, Elena V. Uvarova, Vladimir D. Chuprynin, Natalya A. Buralkina, Irina A. Kiseleva, Fatima Sh Mamedova e Madina A. Chundokova. "The tactics of managing children and adolescents when twisting the uterine appendages from the position of international standards". Gynecology 22, n.º 3 (9 de julho de 2020): 39–41. http://dx.doi.org/10.26442/20795696.2020.3.200148.

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Background. Adnexal torsion (AT) takes fifth place among all emergency gynecological conditions. Suspicion of AT requires immediate diagnosis and urgent surgical treatment. The most common causes of AT are various volumetric formations, such as functional or dermoid ovarian cysts, contributing to an increase in its volume and/or anomalies in the development of the ligamentous apparatus. Timely diagnosis and detorsion contributes to the full restoration of impaired venous outflow and lymphatic drainage of the ovarian tissue, preventing the development of severe ischemia and necrosis. Over the past few decades, a surgical organ-preserving approach in managing patients with AT has been the gold standard of care. Materials and methods. The article describes the results of a retrospective study of cases of AT in children and adolescents treated at the Department of Pediatric and adolescent gynecology Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology with an assessment of the clinical and anamnestic features of this cohort of patients and the choice of therapeutic tactics. Conclusion. A multidisciplinary approach is critical to optimizing the delivery of care in cases of AT, including minimally invasive detorsion and preserving the functionality of the ovary as a treatment standard that should be used in the management of children and adolescents.

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Seregin, Alexander A., Yana A. Kosova, Polina A. Seregina, Yulia N. Ponomareva, Anastasiia B. Nadezhdenskaia, Eleonora V. Kirilova, Aleksandra V. Asaturova et al. "Uterine leiomyosarcoma and disseminated peritoneal leiomyomatosis in the surgical treatment of uterine myoma: a retrospective analysis". Gynecology 24, n.º 5 (30 de novembro de 2022): 386–92. http://dx.doi.org/10.26442/20795696.2022.5.201860.

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Aim. To analyze the incidence and types of adverse outcomes and complications of laparoscopic myomectomies. Materials and methods. This work is a retrospective study based on data from the Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology. We analyzed 711 case histories of patients diagnosed with uterine myoma who received surgical treatment in the Department of Innovative Oncology and Gynecology from 2015 to 2019. The frequency of malignant neoplasms, verified by pathomorphological examination, and the characteristics of surgical interventions performed in these patients were comparatively evaluated. Results. Surgical interventions for uterine myoma are leading in gynecology due to the high prevalence of such disorders. Conservative myomectomy remains the "gold standard" in organ-sparing surgery. However, during surgeries for suspected benign neoplasms, there is a risk of morcellation of the malignant tumor, significantly worsening patient survival outcomes. In our study, the incidence of uterine leiomyosarcoma in suspected benign neoplasms was 0.98%. The probability of parasitic myomas or disseminated perineal leiomyomatosis after myomatous nodule morcellation is 0.19%. Conclusion. No reliable information about the malignant potential of the tumor and its proliferative activity can be obtained until a definitive pathomorphological examination. The above considerations warrant the routine use of prophylactic measures to prevent tumor cell dissemination.

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Semenova, M. V., D. D. Sarrakhov, A. R. Gilimkhanova, A. R. Kamalova, P. G. Vakhitov, А. A. Musina e B. A. Islamgaraev. "Clinical case of pregnancy complicated by thrombotic thrombocytopenic purpura". Acta Biomedica Scientifica 9, n.º 2 (31 de maio de 2024): 50–57. http://dx.doi.org/10.29413/abs.2024-9.2.5.

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Background. Thrombotic thrombocytopenic purpura is a rare blood disease characterized by increased thrombogenesis in the microcirculation. One of the most common triggers for the development of this disease is pregnancy. The article describes a case of pregnancy complicated by thrombotic thrombocytopenic purpura.Materials and methods. To assess the clinical case, we used a retrospective analysis of medical documentation: maternity case record, birth history, results of laboratory and instrumental research methods.Results. A 32-year-old patient was admitted to hospital at week 32 of gestation with manifestations of moderate preeclampsia, thrombocytopenia, and moderate anemia. Due to worsening of the condition, the delivery was performed by cesarean section. Subsequently, the mother’s condition did not improve: thrombocytopenia and hyperbilirubinemia progressed; the level of transaminases increased; ADAMTS13 activity was 8 %. Teleconferences were repeatedly held with experts from the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov (Moscow). Complex therapy including extracorporeal methods led to a positive result; the patient was discharged in satisfactory condition under the supervision of a hematologist and obstetrician-gynecologist.Conclusion. Thrombotic thrombocytopenic purpura treatment tactics have its own characteristics; it is necessary to diagnose this pathology in a timely manner to provide qualified medical care and to prevent maternal and perinatal losses.

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Sezgin, Nurdan, e Gökhan Ersoy. "Kulak Ölçü ve Yerleşiminde Yaşa Bağlı Metrik Değişimler". Bulletin of Legal Medicine 25, n.º 2 (18 de setembro de 2020): 106–15. http://dx.doi.org/10.17986/blm.1273.

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Bu çalışmada, insan yüz profilinde ve kulakta, yaşla birlikte meydana gelen değişiklikler iki cinsiyette de metrik olarak incelendi. Elde edilen değerlerden istatistiksel olarak anlamlı sonuç verenler çalışmaya dahil edildi ve bunların içinde yaşla birlikte sürekli artma/azalma gösteren değerlere odaklanıldı. Çalışmada 166 kadın, 203 erkek olmak üzere 369 gönüllünün yan yüz ve kulak görüntüleri üzerinden ImageJ programıyla ölçüler alındı. Vücut Kitle İndeksi (VKİ) ve yan yüz ve kulak alan hesaplamalarıyla birlikte, 19 antropometrik nokta kullanılarak doğrusal mesafe ölçümleri alındı. Elde edilen veriler SPSS 20.0 (Statistical Package fort he Social Sciences) programına kaydedildi ve analizi yapıldı. Genel olarak iki cinsiyette de kulak bölgesinde alınan doğrusal mesafe ölçümlerinde yaşla birlikte artış olduğu gözlendi. Yan yüz üzerinden alınan ölçülerde kadınlarda istatistiki olarak anlamlılık gözlenmezken, erkeklerde 13 ölçü içerisinde yalnızca 4 tanesinde sürekli artış olduğu belirlendi. Bu çalışmanın amacı, insan yüz profilinde ve kulakta yaşla birlikte meydana gelen değişikliklerin metrik olarak incelenmesi ve ileride yapılacak yaş tahmin çalışmalarına katkı sağlamasıdır.

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Shmakov, R. G., M. M. Pirogova, O. N. Vasilchenko, V. D. Chuprynin, A. V. Piregov, Z. S. Khodzhaeva, N. I. Klimenchenko et al. "Conservative Surgery in Abnormal Placenta Invasion (5-year Experience of V.I. Kulakov National Medical Scientific Centre of Obstetrics, Gynaecology and Perinatal Medicine)". Doctor.Ru 166, n.º 11 (2019): 29–34. http://dx.doi.org/10.31550/1727-2378-2019-166-11-29-34.

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Panchenko, Ivan Sergeevich, Valery Vitalievich Rodionov, Sergey Viktorovich Panchenko e Marat Gakifovich Sharafutdinov. "PHENOTYPIC CHARACTERISTICS OF ANDROGEN RECEPTOR-POSITIVE CANCER IN THE TRIPLE-NEGATIVE BREAST CANCER GROUP". Ulyanovsk Medico-biological Journal, n.º 3 (26 de setembro de 2022): 49–60. http://dx.doi.org/10.34014/2227-1848-2022-3-49-60.

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The aim of the paper is to reveal the phenotypic characteristics of androgen-receptor-positive breast cancer in triple-negative breast cancer. Materials and Methods. The authors analyzed clinical and morphological tumour data in 253 patients with morphologically verified invasive triple-negative breast cancer (TNBC). The patients were treated at the Regional Clinical Oncologic Dispensary (Ulyanovsk) and the Breast Pathology Department of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov (Moscow) from 2014 to 2021. Results. Statistical analysis of 45 patients (18 % of the total sample) showed that androgen receptor (AR) expression in TNBC was observed in patients older than 61 years (p=0.054). It was associated with a more common stage of the disease (starting with IIB) (p=0.004), multifocal growth pattern (p=0.025), invasive lobular cancer (p=0.04), higher tumor differentiation (p<0.0001), low Ki67 level (p=0.000001), and more frequent involvement of regional lymph nodes (p=0.005). At the same time, there were no statistically significant correlations between the AR expression and menstrual function, breast lesion quadrant, and pathomorphological response after neoadjuvant polychemotherapy. Conclusion. AR expression in TNBC occurs in patients over 61 years of age, with a locally advanced disease stage, a multifocal tumor growth pattern, an invasive lobular cancer, and well-differentiated tumors with low proliferative activity.

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Mussagaliyeva, A. S. "«CLEANING OF COLLECTIVE FARNS FROM «KULATSKO-BAYSKY ELEMENT...»: REPRESSIVE POLICY OF THE SOVIET POWER IN THE TELMANOVSK DISTRICT OF THE KARAGANDA REGION IN 1932-1933". History of the Homeland 96, n.º 4 (29 de dezembro de 2021): 125–36. http://dx.doi.org/10.51943/1814-6961_2021_4_125.

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On the basis of archival materials, the article examines some aspects of the daily life of the local population of the Telmanovsky district of the Karaganda region in 1932-1933. The article studies the policy of the Soviet government during the dispossession of kulaks, under the name "cleansing collective farms from the "kulak-bay element" in Telmanovskiy district, Karaganda region. Particular attention is paid to the repression by the authorities during meat procurement and grain procurement, the relationship between local government and the people, the results of these reforms in the demographic and economic sphere in 1933. The archive of Temirtau, including documents of the regional and district administration: decisions and decrees of the committees of the All-Union Communist Party (Bolsheviks), reports of the executive committees, and documents on the eviction of bays and kulaks, directed against the bays and the kulaks. Statistical data were compiled on the quantitative composition of the district's residents after the repressions and dispossession of kulaks, as well as lists of the evicted kulak bays during this campaign. The study shows the course of events of force collectivization, that is, the transformation of collective farms in the Telmanovsky region of livestock production into grain production.

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Ovchinnikov, Vitaly V., e Alexey A. Kulakov. "QUALITY INCREASING OF TECHNICAL AND POTABLE WATER DUE TO COMPLEXATION BETWEEN AMINO ACIDS AND Ca AND Mg SALTS". IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 61, n.º 6 (6 de junho de 2018): 109. http://dx.doi.org/10.6060/tcct.20186106.5691.

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The home heating systems as well as the food industry require a high degree of water purification. In the aims of the increasing of the quality of technical and potable water the experiments on the determination of the rigidity of water have been carried out in the fourth districts of Kazan after the addition to the water samples of β-alanine and l-asparagine as the agents for the complex formation with calcium and magnesium salts. The obtained results showed that the chosen amino acids able to reduce the rigidity and increase the quality of waters in 1.10-1.22 time. The calculated heats of combustion and formation of complexes of calcium and magnesium with alanine and asparagine confirm the conducted experimental results on their stability. Such experimental results prompted us to calculate the heat of combustion (DсH°) and formation (DfH°) of complexes of calcium and magnesium with the mentioned above amino acids [Met(amino acid)2, DсH°, DfH° (kJ mol-1± 0.5 % , respectively), number of valence electrons (N-g)] in according to the scheme of thermochemical research. It has been suggested to introduce the above mentioned amino acids or synthesized on their base little peptides into sorption-filters at the water preparation process.Forcitation:Ovchinnikov V.V., Kulakov A.A. Quality increasing of technical and potable water due to complexation between amino acids and ca and mg salts. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2018. V. 61. N 6. P. 109-112

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Kirsanova, T. V., N. F. Kravchenko, Z. A. Piliya, Z. S. Khodzhaeva, T. A. Fedorova, N. A. Rozina e E. P. Kolobov. "Pregnancy outcomes and complications after renal transplantation". Meditsinskiy sovet = Medical Council, n.º 4 (2 de maio de 2024): 131–39. http://dx.doi.org/10.21518/ms2024-154.

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Introduction. Chronic kidney disease (CKD) in pregnancy poses certain risks of both gestational complications and adverse perinatal outcomes, which increase with the decline of renal function.Aim to access pregnancy outcomes in patients who underwent nephrotransplantation.Materials and methods. Retrospective study of pregnant women who gave birth at Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology in the period from 2005 to 2021: 102 pregnancies in 97 patients were analyzed: five recipients had two successful pregnancies.Results. The average age of pregnant women was 31 ± 4.03 years. In equal proportions, patients underwent related or cadaveric kidney transplantation – 52% (n = 53) and 48% (n = 49) of cases, respectively. The average delivery time was 35.5 ± 2.7 weeks. The average weight of newborns was 2545 ± 655 grams. Premature birth (PB) occurred in 47.1%, the average period of birth was 33.4 ± 2.87 weeks, of which early birth (<32 weeks) was 22.5%. The average period of pregnancy after transplantation was 5 ± 3.31 (1–18) years, this period was not associated with obstetric complications or deterioration of graft function. A significant increase in the following parameters was noted during pregnancy: serum creatinine level (p = 0.006), proteinuria (p = 0.003). The glomerular filtration rate also decreased significantly by the end of pregnancy (p = 0.011). Preeclampsia was the leading cause of decreased graft function during pregnancy (32.4%).Conclusions. In general, pregnancy outcomes after nephrotransplantation are favorable, but there is an increased risk of preeclampsia, preterm birth, including operative delivery, urinary tract infection and anemia.

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Kripinevich, Svetlana Sergeevna. "Civil and criminal procedural approaches to the definition of individual judicial regulation". Право и политика, n.º 7 (julho de 2022): 34–42. http://dx.doi.org/10.7256/2454-0706.2022.7.38244.

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In legal science, such a direction of research as individual legal regulation has become widespread. On its basis, types are distinguished, including individual judicial regulation. This concept is of particular importance for criminal proceedings and its study can lead to new theoretically and practically significant results. Considering that the study of individual judicial regulation has been conducted for many years in the general theory of law, in civil law, the purpose of this work was to generalize their individual results (in terms of the main features of individual judicial regulation) and to develop the main directions of their application in the field of criminal proceedings. The object of the study was relations in the field of judicial criminal procedural activity. Methods of analysis, synthesis, generalization, comparative legal, formal legal, modeling were used in the study. The main results were expressed in the identification of knowledge useful for the science of the criminal process, obtained by scientists in the field of theory of law (V.V. Ershov, V.M. Gorshnev, S.S. Alekseev, etc.), civil law (V.V. Kulakov, A.D. Koretsky, V.V. Gruzdev, etc.) and determining their significance for conducting research of individual judicial regulation in criminal proceedings. The author's conclusion based on the results of the study is the need to develop scientific research in relation to individual judicial regulation in criminal proceedings as a potentially effective means of resolving criminal law conflicts, taking into account the developing trends of procedural contracts, agreements and other vectors that increase the level of individuality of decisions made by the court.

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Barkov, I. Yu, N. K. Tetruashvili, Yu S. Bulatova, L. V. Kim, N. G. Parsadanyan, E. S. Shubina, A. Yu Goltsov e D. Yu Trofimov. "Effect of the Low Molecular Heparin Therapy on Foetal DNA Level in Non-Invasive Prenatal DNA Screening". Doctor.Ru 20, n.º 8 (2021): 19–22. http://dx.doi.org/10.31550/1727-2378-2021-20-8-19-22.

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Study Objective: To evaluate the effect of low molecular heparin (LMH) therapy on non-invasive prenatal DNA screening (NIPS) for chromosomal pathologies. Study Design: cross-sectional study. Materials and Methods. We have examined two groups of pregnant women: group I included 49 patients with constantly low foetal DNA (twice lower than 4%) selected out of 1,505 women examined at Kulakov National Medical Scientific Centre of Obstetrics, Gynaecology and Perinatal Medicine of the Ministry of Health of Russia during the last 2 years. 17 women were administered LMH and 32 women did not receive it. Group II included 113 pregnant women with a normal foetal DNA fraction (at least 4%), that were selected randomly out of patients who were examined during the same period. 56 pregnant women were administered LMH and 57 were not. Next Generation Sequencing was used as an NIPS method. In order to determine the foetal DNA level, we amplified DNA loci with single nucleotide polymorphisms. Study Results. In group I (low foetal DNA fraction), where no LMH therapy was initiated, median values were 3.5% (3.2–3.8%); if LMH was administered, these values made 3.6% (3.4–3.9), while in group II — 7.7% (6.1–9.5%) and 7.9% (6.0–10.5%), respectively; no significant differences (p = 0.29 and p = 0.7, respectively) were recorded in both cases. Conclusion. Use of LMH does not affect NIPS; therefore, it is not necessary to adjust the LMH therapy in pregnant women prior to NIPS. Keywords: non-invasive prenatal DNA screening, heparin, anticoagulants, low molecular heparins, habitual abortion, pregnancy complications.

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Priputnevich, Tatiana V., Lyudmila A. Lyubasovskaya, Marina P. Shuvalova, Elena N. Baibarina e Gennady T. Sukhikh. "Healthcare-associated infections (HAI) in maternity hospitals of Russian Federation (the state of the problem at the beginning of the XXI century)". Annals of the Russian academy of medical sciences 76, n.º 2 (30 de junho de 2021): 133–41. http://dx.doi.org/10.15690/vramn1523.

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Over the past decade, the healthcare system of the Russian Federation has undergone progressive changes in the system of maternity care, which relate to the development of infrastructure and the introduction of new organizational models. In particular, a three-level system of providing medical care to mothers and children has been created, including a network of perinatal centers for patients at high perinatal and obstetric risk. Field events of specialists of National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation to the medical organizations of maternity care in various regions of Russia revealed hot spots that require primary attention: acute shortage of staff for the implementation of diagnostic and therapeutic measures at the modern methodological level, as well as for ensuring epidemiological safety in the medical organizations (medical microbiologists (bacteriologists), clinical pharmacologists and epidemiologists); the lack of registration of healthcare-associated infections, which is associated with the prevailing in the country mainly punitive methods of combating hospital infections. In modern conditions of nursing preterm babies, newborns with various severe somatic and surgical pathologies, it is necessary to know the real indicators of morbidity in order to reasonably and promptly carry out therapeutic and preventive measures; the need to organize modern microbiological laboratories in the perinatal centers with the availability of fast methods (proteomic and molecular-genetic) diagnostics, allowing for microbiological monitoring in specialized departments of newborns and promptly respond to the changes in the epidemiological situation in the hospital, to prevent the development of clinically pronounced cases of healthcare-associated infections.

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Sharafutdinova, D. R., E. N. Balashova, O. V. Ionov, A. R. Kirtbaya, J. M. Golubtsova, A. Yu Ryndin, V. V. Zubkov e D. N. Degtyarev. "Application of near-infrared spectroscopy in extremely and very low birth weight infants for red blood cells transfusion". Pediatric Hematology/Oncology and Immunopathology 19, n.º 3 (9 de outubro de 2020): 18–25. http://dx.doi.org/10.24287/1726-1708-2020-19-3-18-25.

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Near-infrared spectroscopy (NIRS), or cerebral oximetry, is a non-invasive method for assessing the oxidative status (saturation of hemoglobin with oxygen) mainly in the blood of cerebral venous vessels, which is increasingly used in clinical practice, in particular in neonatology. This method allows us to evaluate not only tissue perfusion, but also to determine the differences between the indicators of cerebral and peripheral oxygenation. Few studies have described improvements in tissue oxygenation indicators determined by NIRS after red blood cells transfusion in premature newborns. In our study we registered the oximetry indicators before and after red blood cells transfusion in extremely and very low birth weight infants (n = 55). This clinical study was approved by the Biomedical Research Ethics Committee (Protocol No. 19 dated 17 November 2016) and the Scientific Council of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of the Russian Federation (Protocol No. 19 dated 29 November 2016). Our study demonstrated a statistically significant increase in CrSO2 , SrSO2 , RrSO2 and SCOR and a decrease in C-FTOE, S-FTOE after a blood transfusion. The study also showed that a decrease in NIRS values (SCOR ≤ 0.76, C-FTOE ≥ 0.29, CrSO2 ≤ 64%, SrSO2 ≤ 54%, and RrSO2 ≤ 56%) can serve as an additional non-invasive measure of anemia and its progression; it helps detect a decrease in cerebral oxygenation at an early, preclinical stage of disease, and can also be used as an additional indicator of the need for red blood cell transfusions.

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Gardanova, Z., D. Khritinin e K. Anisimova. "Psychoemotional Disorders in Pregnancy with Hypertensive Complications". European Psychiatry 41, S1 (abril de 2017): S107. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1874.

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Psychoemotional disorders in pregnant women represent a significant medical and social problem as well as the effects caused by this pathology have a profound effect on children born to such mothers, as well as to themselves mothers during and after pregnancy. The goal–psychological correction of psycho-emotional states in pregnant women with hypertensive syndrome by Erickson hypnosis. The study was conducted on the basis of state organization “Research Center for Obstetrics, Gynecology and Perinatology named after Academician VI Kulakov”. The study involved 150 pregnant women with hypertensive syndrome. Seventy-five pregnant women with hypertensive syndrome received psychological correction method of Erickson hypnosis in an amount of 15 sessions. To assess the state of mental and emotional techniques used depression scale Beck Anxiety Scale, Spielberger-Hanin. The study was conducted 4 times–the first, second, and third trimesters of three months after childbirth. When comparing the psycho-emotional state of pregnant women with hypertensive syndrome on the background of psychological adjustment method Erickson hypnosis and in pregnant women with hypertensive syndrome who did not receive psychological correction revealed a statistically significant difference. In pregnant women with hypertensive syndrome who received psychological correction method of Erickson hypnosis, revealed lower levels of depression and situational anxiety than women who did not receive psychological correction. Thus, our study proved the need for psychological correction method of Erickson hypnosis and its effectiveness for stabilizing the psycho-emotional state of pregnant women with hypertensive syndrome and pre-eclampsia prevention.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Smirnaya, Anastasiya Andreevna, Anastasiya Viktorovna Smirnova, Igor' Anatol'evich Ivanov, Vladimir Leonidovich Tyukanov e Tat'yana Borisovna Morozova. "The Influence of the Level of Subjective Control on the Tolerance of Older Adolescents". Конфликтология / nota bene, n.º 1 (janeiro de 2023): 103–19. http://dx.doi.org/10.7256/2454-0617.2023.1.39122.

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The article deals with the problem of the formation of adolescent tolerance and examines the influence of subjective control on the tolerance of older adolescents. The education system, having unique opportunities to expand knowledge about other people who are different from us, their views, culture, as one of the most important tasks, puts forward the problem of forming tolerance among the younger generation. The relevance of this socio-pedagogical problem is due to the need to find effective means of forming tolerance among students. The study was conducted on the basis of the municipal budgetary educational institution "General education institution Gymnasium No. 11 named after A.N. Kulakov" in Krasnoyarsk. The sample of the study was 133 subjects. The female sample is 71 people, the male sample is 62 people, students of grades 9-11. The obtained data and statistical analysis confirmed the dependence of the level of tolerance of older adolescents on sex differences. Girls are tolerant, they are characterized by tolerant forms of behavior, while boys, on the contrary, are more often intolerant, both to the outside world and to people. With the help of Kendall's rank correlation coefficient, data were processed and compared using the methods "Level of subjective control" and "Tolerance Index". The data confirmed the relationship between the level of subjective control and the level of tolerance of older adolescents. Externals have a low tolerance for others, internals have a higher level of tolerance. In addition, the data showed that girls have a higher level of tolerance than boys.

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Shevchenko, Tatyana. "“The ways of soul, mind and heart to God — no one can intercept them...”: Letters of hegumen Amfilokhiy of Konev to prince A. V. Obolensky, 1926–1934". St.Tikhons' University Review 106 (30 de junho de 2022): 132–66. http://dx.doi.org/10.15382/sturii2022106.132-166.

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The publication covers 21 letters by the father-superior of the Konevsky Nativity of the Theotokos Monastery in Finland, hegumen Amphilochius (Kulakov) to the emigrant of the first wave, Prince Alexei Vasilyevich Obolensky in the period 1926-1934. The letters were kept in the archive of the New-Valamo Monastery in Finland and are published for the first time. The first of the submitted letters was written by hegumen Amphilochius on June 23, 1926, the last - on January 27, 1934. Until 1939, the hegumen still congratulated the Obolenskys on Christmas and Easter. The correspondence began when the hegumen was 51 years old, for eight years he wrote about 2-3 letters annually, and after 1934 he sent brief congratulations on church celebrations. Father Amphilochius took monastic vows in the Valaam Monastery in 1908, and in 1920 was moved to the Konevsky Monastery. He became one of the brightest representatives of the old-style movement. It arose after the Finnish Orthodox Church introduced the Gregorian calendar (1921) and the "new" Paschal in 1925. A Church court condemned him and removed from the abbacy for refusing to accept the reform. Nevertheless, the former father-superior remained to live in the monastery, performed general monastic work and prayed in a cell. His correspondence with Obolensky was mainly of a spiritual upbringing nature, however, some references concerned to the church life of that time. The letters are also interesting because of revealing of the inner world and views of one of the "leaders" of the old-style movement in Finland, they show him as a deeply spiritual person devoted to monastic traditions.

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Rodionov, V. V., O. V. Burmenskaya, V. V. Kometova, D. Yu Trofimov, M. V. Rodionova e L. A. Ashrafyan. "Molecular genetic predictors of metastatic lesions of regional lymph nodes in patients with breast cancer". Tumors of female reproductive system 17, n.º 3 (29 de outubro de 2021): 24–36. http://dx.doi.org/10.17650/1994-4098-2021-17-3-24-36.

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Objective: to identify molecular genetic predictors of metastatic spread to regional lymph nodes in patients with breast cancer (BC) based on the analysis of gene expression profile of the primary tumor.Materials and methods. The study included 358 patients with BC who underwent surgical treatment in breast cancer department of Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. Among all included into the study patients, 132 (36.9 %) had metastases in at least one axillary lymph node. Molecular genetic examination of the tumor tissue was carried out using reverse transcription polymerase chain reaction; the diagnostic panel consisted of 45 functional and 3 reference genes. Results. Patients with metastases to regional lymph nodes were generally younger (p = 0.006), had larger primary tumor (p<0.001) and higher total malignancy score (p<0.001). The groups were also significantly different in tumor location (p = 0.005). Comparative analysis of transcriptome tumor profiling revealed statistically significant differences between groups in the level of expression of three genes: TMEM45A (p = 0.016), CCND1 (p = 0.019), and MIA (p = 0.046). Based on the data obtained we used mathematical modeling and created a predictive model, which with a high degree of probability (AUC = 0.791) allowed to predict the presence of regional lymph nodes metastases in patients with BC.Conclusion. TMEM45A, CCND1 and MIA gene expression in the primary tumor were the markers of lymph node involvement in BC. The developed predictive genetic signature can become an additional diagnostic tool to predict the risk of lymph node metastases at the point of planning the volume of axillary surgery in patients with BC.

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Kulakov, Vladimir. "Vakarų baltų peilių-durklų genezė". Archaeologia Lituana 14 (1 de janeiro de 2013): 36–50. http://dx.doi.org/10.15388/archlit.2013.0.2643.

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Šiandieninis Vidurio ir Vakarų Europos vėlyvojo romėniškojo laikotarpio vienašmenių kovos peilių ištirtumo lygis leidžia iškelti naują vakarų baltų peilių-durklų genezės versiją. Ši egzotiška šaltojo ginklo forma sujungia trikampių Turovo tipo geležčių ir „trumpųjų“ saksų idėjas. Šių unikalaus pavidalo ginklų paplitimo arealai sutampa su vakarų baltų „galindų“ migracijos punktais. Vieno iš prūsiškųjų peilių-durklų (kapas SH – 24 Warthen / Šoseinoje kapinyne) gamybos vieta taip pat sutampa su vienu iš tų punktų. „Galindų“ ir peilių-durklų atsiradimo procesas akivaizdus. Jų etnokultūrinėje erdvėje peilių, skirtų vien tik duriamajam smūgiui, gamybos idėja atsirado susipažinus su Turovo tipo peiliais Galicijoje ir „trumpaisiais“ saksais Lombardijoje, t. y. netrukus po 415 m. Sprendžiant iš kapo Do-370 Dollkeimo-Kovrovo įkapių, pirmieji peiliai-durklai Semboje karių (o būtent jiems buvo skirtas ir ankstesnis romėniškais kalavijas – gladius) kapuose atsiranda V a. po Kr. pradžioje. Susidaro įspūdis, kad pirmųjų peilių-durklų savininkai, besiruošiantys juos panaudoti pagal Turovo tipo peilių paskirtį prieš apsišarvavusius priešininkus, buvo priversti pasitraukti iš jų dislokacijos vietos ir atsidurti ten, kur apie šarvus niekas net nenutuokė – Gintaro krašto platybėse. Galbūt, dedant šiuos ginklus į karių kapus, kartu buvo pabrėžiamas ypatingas jų statusas – priklausymas būriams, galintiems kovoti su šarvuotais kariais. Peilių-durklų pasiskirstymas pietryčių Baltijoje parodo kelis jų išplitimo mikroregionus: 1. Šiaurės Vakarų Semba, turtingiausias pasaulyje gintaro paplitimo regionas – didžiausia ir akivaizdžiai pagrindinė peilių-durklų radaviečių koncentracija. 2. Minijos upės baseinas prie šiaurės vakarinio Kuršių nerijos galo. 3. Nemuno dešiniojo intako Jūros žiotys. 4. Nemuno dešiniojo intako Neries žiotys. Peilių-durklų radaviečių koncentracijos žymi prekybos operacijų bazę – gintaringąją Sembą ir Nemuno prekybos kelio vertingosios prekės plitimo mazgą – Nemuno baseino upių žiotis. Iš rusų k. vertė Aleksiejus Luchtanas... />Vladimir Kulakov...

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Трофимов, Д. Ю., Е. Л. Сим, Е. Г. Гребенщикова, Е. А. Померанцева, Н. С. Павлова, А. И. Коровко, О. А. Буяновская et al. "Attitudes of newborns` mothers toward neonatal whole exome testing: results of a combined study". Nauchno-prakticheskii zhurnal «Medicinskaia genetika 22, n.º 9 (1 de novembro de 2023): 40–46. http://dx.doi.org/10.25557/2073-7998.2023.09.40-46.

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Представлены результаты комбинированного (смешанного) эмпирического исследования отношения матерей новорожденных к полноэкзомному неонатальному тестированию, реализованного в 2021-2022 гг. на базе ФГБУ «НМИЦ АГП им. В.И. Кулакова». Исследование включало анкетирование 328 женщин и проведение 31 полуструктурированного глубинного интервью. В результате исследования выявлен значительный интерес респондентов к неонатальному генетическому тестированию, который соотносится с высоким доверием научным знаниям в области медицинской генетики, достижениям и открытиям в области науки и технологий. Развитие и расширение программ генетического тестирования в неонатологии требует разработки разными специалистами критериев информирования с учетом степени риска, наличия лечения и других факторов. Также дальнейшего исследования требует оценка риска конкретных заболеваний, что позволит применять достижения генетики не только для диагностики и профилактики, но и для планирования семьи. The article presents the results of a combined (mixed) empirical study of attitudes of newborns’ mothers’ toward whole exome testing in neonatology, conducted in 2021-2022 at the «National medical research center for obstetrics, gynecology and perinatology named after academician V.I. Kulakov». The study involved questionnaires of 328 women and 31 semi-structured in-depth interviews with some of them. The study revealed a significant interest of respondents in neonatal genetic testing, which correlates with high trust in scientific knowledge in the field of medical genetics, achievements and discoveries in the field of science and technology. The development and expansion of genetic testing programs in neonatology requires the formulation of informing criteria, taking into account the degree of risk, availability of treatment and other factors. Also, further research is required to assess the risk of specific diseases, which will make it possible to apply the achievements of genetics not only for diagnosis and prevention, but also for family planning.

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Popova, A. Yu, S. I. Gamidov, R. I. Ovchinnikov, I. V. Ushakova e O. N. Golubeva. "Experience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology". Andrology and Genital Surgery 16, n.º 2 (13 de agosto de 2015): 51. http://dx.doi.org/10.17650/2070-9781-2015-16-2-51-55.

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Markov, Boris A., e Yury I. Sukharev. "Probabilistic and dynamic colloid equations". Butlerov Communications 57, n.º 3 (31 de março de 2019): 33–41. http://dx.doi.org/10.37952/roi-jbc-01/19-57-3-33.

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We obtained two equations that characterize the structure of the colloid: the equation of the Schrodinger type that specifies the redistribution of heat and potential energy in the colloid and material equation – the diffusion equation with the operator of Liesegang associated directly with a substance that allows you to find the discontinuities of the structures caused by the vibrations of electrically charged particles. This procedure based on the assumption of the instability of the colloidal state, caused by the movement of charged particles. The reality is not collected in parts from the particles of matter in the course of evolution from the past to the future, and is all at once from the past to the future for a given pattern, that is, for specific PATTERNS, as defined by quantum theory. Without going deep into the theory of Kulakov, we will accept its fundamental provisions as a certain given. The forms of this structural data were obtained experimentally and mathematically confirmed. Let there be a certain angle of the skeleton, where due to the unevenness and partial randomness of the structure of the core grids forms "defects" – that is, electrical or magnetic moments of a particular order. Then small mobile clusters are attracted to it by electrostatic or electromagnetic forces, which are then adsorbed and somehow arranged on the "defects" in accordance with their dipole moments. This circumstance can be determined by "magic numbers", that is, as the number of clusters "stuck" to the defect of the core structure, with the formation of chemical bonds in the future. We can assume that the spanning structure of Coxeter can form small clusters form regular polyhedrons, and may occur or other structure having more complicated form.

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Vinogradova, Maria A., Alexander D. Kulagin e Roman G. Shmakov. "Pregnancy in paroxysmal nocturnal hemoglobinuria: from survival to life". Terapevticheskii arkhiv 94, n.º 7 (12 de agosto de 2022): 859–64. http://dx.doi.org/10.26442/00403660.2022.07.201714.

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Background. Pregnancy in paroxysmal nocturnal hemoglobinuria (PNH) patients has historically been a high-risk situation. The combination of chronic complement-mediated hemolysis caused by the disease and physiological activation of the complement system during pregnancy, significantly worsened the prognosis for the life. For a long time, there were no effective methods for the PNH treatment, and pregnancy in patients seemed to be extremely risky, as it significantly increased the risk of life-threatening complications. The advent of targeted therapy with eculizumab turned the prognosis of this disease upside down: patients began not only to survive, but also to live comparable to healthy people. A comparative analysis of the course and outcomes of pregnancy in patients with PNH treated with eculizumab and in patients without targeted therapy was carried out. Aim. The study was to evaluate the course and outcomes of pregnancy in patients with PNH, depending on the therapeutic approach. Materials and methods. We analyzed data from 57 pregnancies in 49 women (31 used eculizumab, 26 with supportive care only) observed at the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology or with remote consultation (23 clinics from 19 cities of Russia). Results. The high probability of pregnancy complications and its adverse outcomes outside of targeted therapy indicates the vital need for its use: all observations were accompanied by complications of varying severity. The course of pregnancy with the eculizumab is generally more favorable: an apparently higher rate of live births and a lower likelihood of complications are registered. Without increasing the incidence of complications, eculizumab significantly improves pregnancy outcomes for both mother and fetus, and does not adversely affect the health of newborns. Conclusion. Thus, eculizumab allows not only to increase the survival rate of patients with PNH, but also to comprehensively improve their quality of life, including the possibility of safe childbirth.

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Naumov, N. P., T. V. Shatylko, S. I. Gamidov, A. Y. Popova e R. I. Safiullin. "Sperm agglutination and ejaculate liquefaction time as negative prognostic factor in ICSI". Andrology and Genital Surgery 23, n.º 3 (12 de setembro de 2022): 61–71. http://dx.doi.org/10.17650/2070-9781-2022-23-3-61-71.

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Background. Not all pathological mechanisms of fertility disorders in men are currently the correct diagnostic tests, this significantly reduces the prognostic value of the spermogram and makes the question of assessing spermogram character disorders and its impact on the effectiveness of assisted reproductive technologies (ART) procedures extremely relevant. In our study, we retrospectively evaluated the parameters of ejaculate and their effect on ART outcomes.Aim. To assess the effect of sperm agglutination and ejaculate liquefaction time on in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) results.Materials and methods. The selection of married couples was carried out on the basis of the V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology of the Ministry of Health of Russia. The study included 6,416 married couples who sought IVF-ICSI in the period from December 2012 to December 2016. Ages of men varied between 23 and 74 years, ages of women between 17 and 53 years. Examination data of the patients were extracted from the BABE software. In the study, sperm analysis parameters were evaluated during preparation to the IVF program, IVF-ICSI, and on the day of transvaginal ovarian puncture. Using univariant and regression analysis, prognostic factors of clinical pregnancy and childbirth after IVF-ICSI were determined.Results. Sperm agglutination rates adversely affect the incidence of clinical pregnancy (probability ratio (PR) 0.701; 95 % confidence interval (CI) 0.589–0.834; p <0.001) and childbirth (PR 1.719; 95 % CI 1.220–2.422; p = 0.002) in IVF-ICSI assisted reproductive technologies. Ejaculate liquefaction has a negative effect on the incidence of clinical IVF-ICSI pregnancy (PR 0.967; 95 % CI 0.949–0.986; p = 0.001).Conclusion. Andrologists should seek to improve the above ejaculate parameters with various treatments to improve the effectiveness of ART programs.

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Nizyaeva, N. V., N. A. Lomova, E. L. Dolgopolova, T. E. Karapetyan, U. L. Petrova, R. G. Shmakov e V. E. Frankevich. "Detection of SARS-Cov-2 N-protein in Mesenchymal Cells of Umbilical Warton's Jelly in Women with COVID-19". Biomedical Chemistry: Research and Methods 5, n.º 1 (2022): e00165. http://dx.doi.org/10.18097/bmcrm00165.

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Despite the large number of studies on the new coronavirus infection SARS-Cov-2 characterized by vascular damage on the impact of the virus on the mother-placenta-fetus system remains unknown. The umbilical cord, according to its functional purpose, is a complex of vessels protected from external influences by the embryonic connective tissue –Wharton's jelly. The aim of the study was to detect the structural components of SARS-Cov-2 in the histological structures of umbilicals cord in patients with COVID-19 in the tissues of the umbilical cord of women with COVID-19. The main group included 40 pregnant women who were treated at the academician V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (March-April 2020) with a confirmed diagnosis of COVID-19 (according to the positive PCR test of a nasopharyngeal swab) and 40 pregnant women of the comparison group, without clinical symptoms and laboratory tests, including the negative PCR test. As a result of the immunohistochemical study of the umbilical cord with primary antibodies to the SARS-Cov-2 N-protein in the COVID-19 group, staining of the cytoplasm of fibroblast-like cells and single macrophages Wharton's jelly was detected (p<0.05). In the group of women without coronavirus infection no staining in Wharton's jelly cells was detected. The probable persistence of viral particles in mesenchymal cells and macrophages of the Wharton's jelly in the umbilical cord can be important for establishment new aspects of influence COVID-19 on the mother-placenta-fetus system. Our results suggesting persistence of COVID-19 viral proteins in mesenchymal cells of the umbilical cord could be an important in establishing new pathogenic mechanisms for the fetal protection against viruses.

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Ryumina, I. I., M. M. Markelova, M. V. Narogan, I. V. Orlovskaya, A. E. Perepelkina, A. Yu Ryndin, E. A. Gatina et al. "Experience in implementing the International Standards for Assessing Newborn Growth INTERGROWTH-21<sup>st</sup>". Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 66, n.º 1 (31 de março de 2021): 117–24. http://dx.doi.org/10.21508/1027-4065-2021-66-1-117-124.

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The physical development of newborns and infants is the most important parameter in assessing their health. However, the standards of anthropometric parameters, and most importantly their growth in premature babies, especially those born with low and extremely low body weight, are still controversial.Objective: to apply the methodology for measuring and assessing the main anthropometric indicators of newborns using the international standards of postnatal growth of premature babies INTERGROWTH-21st to resolve the issue of the feasibility of its adaptation and widespread introduction into neonatological and pediatric practice in the Russian Federation. 4876 children were born at Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (participant of the international project for the implementation of INTERGROWTH-21st standards in neonatological and pediatric practice) from 15.05.2018 to 26.11.2018. 439 (9%) of them were born premature, of which 376 children (89,3%) with gestational age confirmed by ultrasound were included in the study. There was a detailed file for each child to assess the environment and health of the mother, the course of pregnancy, childbirth, the state of health of the child from birth to discharge from the hospital. 2.1% of children classified by INTERGROWTH-21st as children with intrauterine growth retardation, according to Fenton charts, had normal intrauterine growth. When comparing the postnatal growth at discharge from hospital on the Fenton scale, more children were classified as children with impaired postnatal growth; the discrepancy between INTERGROWTH-21st and Fenton diagrams was 8%. At discharge, 52% of premature babies were exclusively breastfed, 28.8% of premature babies were at mixed feeding.Conclusion. On the one hand, the use of INTERGROWTH-21st scales helps to correct nutrition in case of delay in physical development, and, on the other hand, it reduces the risk of metabolic disorders associated with an aggressive desire to achieve rapid growth of a premature baby.

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Attoeva, Djamilya I., Alexandra V. Asaturova, Vera N. Prilepskaya, Nataliia L. Starodubtseva, Polina L. Sheshko e Ada T. Uruymagova. "Comparison of the results of clinical and morphological methods of research in HPV-associated diseases of the cervix (retrospective study)". Gynecology 23, n.º 1 (21 de março de 2021): 78–82. http://dx.doi.org/10.26442/20795696.2021.1.200647.

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Aim. To conduct a retrospective analysis and evaluate the morphological methods for HPV-related intraepithelial lesions detection in women of reproductive age. Materials and methods. The data of cytological diagnosis, as well as the results of histological reports were analyzed for the period from 2018 to 2019. A comparative analysis was performed in 415 patients with HPV-related intraepithelial lesions, who applied to the scientific and polyclinic department of the Kulakov National Research Medical Center at the age of 19 to 45 years. Morphological examination was carried out by specialists of the 1st pathology department of the Center. Results. According to the results of a comparative analysis of cytological and histological conclusions, 3 groups were formed: 1 the group of coincidence (agree) of cytological and histological conclusions; 2 group of minor discrepancies (minor under/ over) between cytological and histological finding; 3 group of major discrepancies (major under/ over) between cytological and histological findings. Cytological and histological compliance was achieved in 194 (46.74%) patients. The total number of minor nonconformities was 192 (46%) cases. The total number of significant discrepancies between cytological and histological findings was 29 (6.9%) patients: 20 (4.8%) cases were found in the group NILM, hr. cervicitis HSIL and 9 (2.1%) cases in the group HSIL hr. cervicitis according to the results of histological examination. Conclusion. Cervical screening reduces the risk of breast cancer due to cytological examination of the cervix, but histological examination is crucial in making a correct diagnosis, since its result determines the choice of treatment method. The comparative analysis showed that in all groups there were cases of hypo- and hyperdiagnostics during cytological examination although the major discrepancies which can change treatment algorithm, were found only in 6.8% cases.

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Ionov, O. I., E. E. Kosterina, A. R. Kirtbaya, E. N. Balashova, A. M. Krasnyi, A. S. Petrova, A. S. Grusynova et al. "Gradual advancement of enteral feeding in preterm newborns: preliminary results of a multicenter prospective randomized study". Voprosy praktičeskoj pediatrii 17, n.º 1 (2022): 113–21. http://dx.doi.org/10.20953/1817-7646-2022-1-113-121.

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Objective. To assess safety and effectiveness of gradual advancement of enteral feeding in preterm newborns with a gestational age of ≤32 weeks and compare it with conventional feeding strategy. Patients and methods. This multicenter prospective randomized study is still ongoing in V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia and Moscow Regional Perinatal Center. This pilot study included 36 patients with a gestational age of 28/0-32/6 weeks and birth weight 836 g to 2210 g treated in these two institutions between June and December 2020. Study participants were randomly assigned to either experimental or control group. Newborns in the experimental group received enteral nutrition with gradual advancement at each feeding, while newborns in the control group were fed according to a standard scheme with the advancement made twice a day. The daily rate of enteral feeding advancement was 30 ml/kg/day. Results. Gradual advancement of enteral feeding in the experimental group (n = 17) allowed its participants to reach the targeted daily volumes of 100 and 160 mL/kg faster than controls (n = 19) without any increase in the incidence of necrotizing enterocolitis and gastrointestinal dyskinesia. This ensured shorter (1.5 times) duration of central venous catheter use and length of stay in the intensive care unit among newborns with a birth weight <1500 g. Conclusion. Preliminary results of our study suggest safety and effectiveness of gradual advancement of enteral feeding compared to traditional feeding strategy in newborns with a gestational age of 28/0-32/6 weeks. Since our sample was rather small, the benefits and safety of gradual feeding advancement should be further investigated. Key words: preterm newborn, enteral nutrition, feeding, very low birth weight, extremely low birth weight, necrotizing enterocolitis

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