Artigos de revistas: "Interleukin-6"

1

&NA;. "Interleukin-3/interleukin-6". Reactions Weekly &NA;, n.º 550 (maio de 1995): 11. http://dx.doi.org/10.2165/00128415-199505500-00035.

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2

&NA;. "Interleukin-6". Reactions Weekly &NA;, n.º 570 (setembro de 1995): 9. http://dx.doi.org/10.2165/00128415-199505700-00023.

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3

Lotz, Martin. "Interleukin-6". Cancer Investigation 11, n.º 6 (janeiro de 1993): 732–42. http://dx.doi.org/10.3109/07357909309046948.

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4

&NA;. "Interleukin 6". Inpharma Weekly &NA;, n.º 877 (março de 1993): 2. http://dx.doi.org/10.2165/00128413-199308770-00001.

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5

&NA;. "Interleukin 6". Reactions Weekly &NA;, n.º 505 (junho de 1994): 8. http://dx.doi.org/10.2165/00128415-199405050-00037.

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6

&NA;. "Interleukin 6". Reactions Weekly &NA;, n.º 531 (dezembro de 1994): 8. http://dx.doi.org/10.2165/00128415-199405310-00027.

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7

Song, Mingchen, e John A. Kellum. "Interleukin-6". Critical Care Medicine 33, Suppl (dezembro de 2005): S463—S465. http://dx.doi.org/10.1097/01.ccm.0000186784.62662.a1.

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8

CASTELL, JOSé V., TILO ANDUS, DIETER KUNZ e PETER C. HEINRICH. "Interleukin-6". Annals of the New York Academy of Sciences 557, n.º 1 (28 de junho de 2008): 87–101. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24001.x.

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9

LEE, FRANK, CHOY-PIK CHIU, JANUSZ WIDEMAN, PHILLIP HODGKIN, SUSAN HUDAK, LOUISE TROUTT, THERESA NG et al. "Interleukin-6". Annals of the New York Academy of Sciences 557, n.º 1 (28 de junho de 2008): 215–29. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24015.x.

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10

CLARK, STEVEN C. "Interleukin-6". Annals of the New York Academy of Sciences 557, n.º 1 (28 de junho de 2008): 438–43. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24036.x.

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11

Olencki, Thomas, James Finke e Ronald M. Bukowski. "Interleukin-6". Clinical Immunotherapeutics 2, n.º 4 (outubro de 1994): 278–94. http://dx.doi.org/10.1007/bf03258528.

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12

Sin, Don D., e S. F. Paul Man. "Interleukin-6". Chest 133, n.º 1 (janeiro de 2008): 4–6. http://dx.doi.org/10.1378/chest.07-2085.

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13

Delk, Nikki A., e Mary C. Farach-Carson. "Interleukin-6". Autophagy 8, n.º 4 (abril de 2012): 650–63. http://dx.doi.org/10.4161/auto.19226.

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14

Matsuda, Tadashi, e Toshio Hirano. "Interleukin 6 (IL-6)". Biotherapy 2, n.º 4 (outubro de 1990): 363–73. http://dx.doi.org/10.1007/bf02170085.

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15

Rivera-Chavez, Fernando A., Dixie L. Peters-Hybki, Robert C. Barber e Grant E. O'Keefe. "Interleukin-6 Promoter Haplotypes and Interleukin-6 Cytokine Responses". Shock 20, n.º 3 (setembro de 2003): 218–23. http://dx.doi.org/10.1097/00024382-200309000-00004.

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16

Ridker, Paul M. "Targeting Interleukin-1 and Interleukin-6". Journal of the American College of Cardiology 76, n.º 15 (outubro de 2020): 1774–76. http://dx.doi.org/10.1016/j.jacc.2020.08.052.

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17

NORTHEMANN, WOLFGANG, TODD A. BFUCIAK, MASAHIRA HATTORI e GEORG H. FEY. "Rat Interleukin-6". Annals of the New York Academy of Sciences 557, n.º 1 (28 de junho de 2008): 536–39. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24057.x.

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18

Schneider, Kirsten, Reinhard Klaas, Bernd Kaspers e Peter Staeheli. "Chicken interleukin-6". European Journal of Biochemistry 268, n.º 15 (1 de agosto de 2001): 4200–4206. http://dx.doi.org/10.1046/j.1432-1327.2001.02334.x.

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19

Tamura, T., N. Udagawa, N. Takahashi, C. Miyaura, S. Tanaka, Y. Yamada, Y. Koishihara, Y. Ohsugi, K. Kumaki e T. Taga. "Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6." Proceedings of the National Academy of Sciences 90, n.º 24 (15 de dezembro de 1993): 11924–28. http://dx.doi.org/10.1073/pnas.90.24.11924.

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20

Ogawa, Michio, Kiyoshi Sakamoto, Seiji Mita, Takatoshi Ishiko e Saburo Hisano. "INTERLEUKIN-6 AND SOLUBLE INTERLEUKIN-6 RECEPTOR IN SURGICAL TRAUMA". Shock 4, Supplement (dezembro de 1995): 11. http://dx.doi.org/10.1097/00024382-199512001-00045.

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21

De Filippo, G., D. Rendina, F. Moccia, V. Rocco e A. Campanozzi. "Interleukin-6, soluble interleukin-6 receptor/interleukin-6 complex and insulin resistance in obese children and adolescents". Journal of Endocrinological Investigation 38, n.º 3 (23 de setembro de 2014): 339–43. http://dx.doi.org/10.1007/s40618-014-0176-4.

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22

Oka, Masaaki, Hiroshi Kusanagi, Toshihiro Saeki, Norio Iizuka, Hiroto Hayashi, Akira Tangoku, Takuo Murakami e Takashi Suzuki. "Interleukin-6 Production and Interleukin-6 Receptor Expression in Human Esophageal Cancer Cell Lines". Japanese Journal of Gastroenterological Surgery 26, n.º 11 (1993): 2707. http://dx.doi.org/10.5833/jjgs.26.2707.

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23

Prens, Errol P., Klazina Benne, Jozef van Damme, Marleen Bakkus, Karin Brakel, Robbert Benner e Theodoor van Joost. "Interleukin-1 and Interleukin-6 in Psoriasis". Journal of Investigative Dermatology 95, n.º 6 (dezembro de 1990): S121—S124. http://dx.doi.org/10.1111/1523-1747.ep12874991.

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24

Bota, Rafaqat, e Mushtaq Ahmed. "The pathophysiological profile of interleukin-6 and anti-interleukin-6 antibody". El Mednifico Journal 1, n.º 2 (6 de julho de 2013): 51. http://dx.doi.org/10.18035/emj.v1i2.26.

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25

Ridker, Paul M., e Manas Rane. "Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease". Circulation Research 128, n.º 11 (28 de maio de 2021): 1728–46. http://dx.doi.org/10.1161/circresaha.121.319077.

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Resumo:

IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of physiological functions traditionally associated with host defense, immune cell regulation, proliferation, and differentiation. Following recognition of innate immune pathways leading from the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome to IL-1 to IL-6 and on to the hepatically derived clinical biomarker CRP (C-reactive protein), an expanding literature has led to understanding of the proatherogenic role for IL-6 in cardiovascular disease and thus the potential for IL-6 inhibition as a novel method for vascular protection. In this review, we provide an overview of the mechanisms by which IL-6 signaling occurs and how that impacts upon pharmacological inhibition; describe murine models of IL-6 and atherogenesis; summarize human epidemiological data outlining the utility of IL-6 as a biomarker of vascular risk; outline genetic data suggesting a causal role for IL-6 in systemic atherothrombosis and aneurysm formation; and then detail the potential role of IL-6 inhibition in stable coronary disease, acute coronary syndromes, heart failure, and the atherothrombotic complications associated with chronic kidney disease and end-stage renal failure. Finally, we review anti-inflammatory and antithrombotic findings for ziltivekimab, a novel IL-6 ligand inhibitor being developed specifically for use in atherosclerotic disease and poised to be tested formally in a large-scale cardiovascular outcomes trial focused on individuals with chronic kidney disease and elevated levels of CRP, a population at high residual atherothrombotic risk, high residual inflammatory risk, and considerable unmet clinical need.

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26

Jucker, M., H. Abts, W. Li, R. Schindler, H. Merz, A. Gunther, C. von Kalle, M. Schaadt, T. Diamantstein e AC Feller. "Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease". Blood 77, n.º 11 (1 de junho de 1991): 2413–18. http://dx.doi.org/10.1182/blood.v77.11.2413.2413.

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Abstract Interleukin-6 (IL-6) is a multipotent lymphokine that can mediate differentiation of B cells into Ig-secreting cells, stimulate the growth of plasmacytomas, hybridomas, and T cells, and induce acute- phase proteins in liver cells. It has been suggested that IL-6 is involved in the pathogenesis of several diseases by autocrine or paracrine pathways. To examine whether IL-6 is possibly involved in the pathophysiology of Hodgkin's disease (HD), we analyzed the expression of IL-6 and IL-6 receptor mRNA and protein in cell lines and primary specimens from patients with HD. IL-6-specific transcripts were detected in three of six HD-derived cell lines by Northern blot analysis. In the culture supernatants of four HD-derived cell lines, IL- 6 was detected by radioimmunoassay. Biologic activity of IL-6 was confirmed by proliferation of an IL-6-dependent cell line. In situ hybridization experiments showed IL-6-specific transcripts in Hodgkin (H) and Reed-Sternberg (RS) cells in primary tissues of two patients. In addition, mRNAs specific for the IL-6 receptor were detected in five HD-derived cell lines. Immunostaining experiments showed expression of IL-6 receptor molecules on H and RS cells in 8 of 16 cases with HD. Thus, our data suggest that IL-6 might be involved in the pathophysiology of HD.

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27

Jucker, M., H. Abts, W. Li, R. Schindler, H. Merz, A. Gunther, C. von Kalle, M. Schaadt, T. Diamantstein e AC Feller. "Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease". Blood 77, n.º 11 (1 de junho de 1991): 2413–18. http://dx.doi.org/10.1182/blood.v77.11.2413.bloodjournal77112413.

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Interleukin-6 (IL-6) is a multipotent lymphokine that can mediate differentiation of B cells into Ig-secreting cells, stimulate the growth of plasmacytomas, hybridomas, and T cells, and induce acute- phase proteins in liver cells. It has been suggested that IL-6 is involved in the pathogenesis of several diseases by autocrine or paracrine pathways. To examine whether IL-6 is possibly involved in the pathophysiology of Hodgkin's disease (HD), we analyzed the expression of IL-6 and IL-6 receptor mRNA and protein in cell lines and primary specimens from patients with HD. IL-6-specific transcripts were detected in three of six HD-derived cell lines by Northern blot analysis. In the culture supernatants of four HD-derived cell lines, IL- 6 was detected by radioimmunoassay. Biologic activity of IL-6 was confirmed by proliferation of an IL-6-dependent cell line. In situ hybridization experiments showed IL-6-specific transcripts in Hodgkin (H) and Reed-Sternberg (RS) cells in primary tissues of two patients. In addition, mRNAs specific for the IL-6 receptor were detected in five HD-derived cell lines. Immunostaining experiments showed expression of IL-6 receptor molecules on H and RS cells in 8 of 16 cases with HD. Thus, our data suggest that IL-6 might be involved in the pathophysiology of HD.

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28

Plenz, Gabriele, Heike Eschert, Michael Erren, Thomas Wichter, Michael Böhm, Markus Flesch, Hans H. Scheld e Mario C. Deng. "The interleukin-6/interleukin-6-receptorsystem is activated in donor hearts". Journal of the American College of Cardiology 39, n.º 9 (maio de 2002): 1508–12. http://dx.doi.org/10.1016/s0735-1097(02)01791-6.

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29

Nancey, Stéphane, Nadim Hamzaoui, Driffa Moussata, Ivan Graber, Jacques Bienvenu e Bernard Flourie. "Serum Interleukin-6, Soluble Interleukin-6 Receptor and Crohn’s Disease Activity". Digestive Diseases and Sciences 53, n.º 1 (5 de junho de 2007): 242–47. http://dx.doi.org/10.1007/s10620-007-9849-6.

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30

Angelis, Pela, Simon Scharf, Alastair Mander, Frank Vajda e Nicholas Christophidis. "Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease". Neuroscience Letters 244, n.º 2 (março de 1998): 106–8. http://dx.doi.org/10.1016/s0304-3940(98)00136-0.

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31

Rezai, Ali R., Ahmad Rezai, Otoniel Mart�nez-Maza, Meta Vander-Meyden e Martin H. Weiss. "Interleukin-6 and interleukin-6 receptor gene expression in pituitary tumors". Journal of Neuro-Oncology 19, n.º 2 (junho de 1994): 131–35. http://dx.doi.org/10.1007/bf01306454.

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32

MONTERO-JULIAN, F. A., E. GAUTHEROT, J. WIJDENES, B. KLEIN e H. BRAILLY. "Pharmacokinetics of Interleukin-6 During Therapy with Anti-Interleukin-6 Monoclonal Antibodies: Enhanced Clearance of Interleukin-6 by a Combination of Three Anti-Interleukin-6 Antibodies". Journal of Interferon Research 14, n.º 5 (outubro de 1994): 301–2. http://dx.doi.org/10.1089/jir.1994.14.301.

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33

KENIS, G., C. TEUNISSEN, R. DEJONGH, E. BOSMANS, H. STEINBUSCH e M. MAES. "STABILITY OF INTERLEUKIN 6, SOLUBLE INTERLEUKIN 6 RECEPTOR, INTERLEUKIN 10 AND CC16 IN HUMAN SERUM". Cytokine 19, n.º 5 (setembro de 2002): 228–35. http://dx.doi.org/10.1016/s1043-4666(02)91961-7.

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34

Kenis, Gunter, Charlotte Teunissen, Raf De Jongh, Eugène Bosmans, Harry Steinbusch e Michael Maes. "STABILITY OF INTERLEUKIN 6, SOLUBLE INTERLEUKIN 6 RECEPTOR, INTERLEUKIN 10 AND CC16 IN HUMAN SERUM". Cytokine 19, n.º 5 (setembro de 2002): 228–35. http://dx.doi.org/10.1006/cyto.2002.1961.

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35

HIRANO, TOSHIO. "Interleukin 6 (IL-6) and disease." Japanese Journal of Clinical Immunology 13, n.º 5 (1990): 444–45. http://dx.doi.org/10.2177/jsci.13.444.

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36

Van Wagoner, N. J., e E. N. Benveniste. "Interleukin-6 regulation in human astrocytes: Synergy between TNF-alpha, interleukin-6, and the soluble-interleukin-6 receptor-alpha". Journal of Neuroimmunology 90, n.º 1 (setembro de 1998): 53. http://dx.doi.org/10.1016/s0165-5728(98)91497-7.

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37

Hoejberg, Lise, Lars Bastholt e Henrik Schmidt. "Interleukin-6 and melanoma". Melanoma Research 22, n.º 5 (outubro de 2012): 327–33. http://dx.doi.org/10.1097/cmr.0b013e3283543d72.

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38

Rose-John, Stefan. "Interleukin-6 Family Cytokines". Cold Spring Harbor Perspectives in Biology 10, n.º 2 (15 de junho de 2017): a028415. http://dx.doi.org/10.1101/cshperspect.a028415.

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39

Tanaka, Toshio, Masashi Narazaki e Tadamitsu Kishimoto. "Interleukin (IL-6) Immunotherapy". Cold Spring Harbor Perspectives in Biology 10, n.º 8 (4 de agosto de 2017): a028456. http://dx.doi.org/10.1101/cshperspect.a028456.

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40

Suzuki, Kenshi, Akiko Miyashita, Yasuyuki Inoue, Seiko Iki, Hidetoshi Enomoto, Yuji Takahashi e Tamiko Takemura. "Interleukin-6-Producing Pheochromocytoma". Acta Haematologica 85, n.º 4 (1991): 217–19. http://dx.doi.org/10.1159/000204897.

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41

Kerr, Ron, David Stirling e Christopher A. Ludlam. "Interleukin 6 and Haemostasis". British Journal of Haematology 115, n.º 1 (outubro de 2001): 3–12. http://dx.doi.org/10.1046/j.1365-2141.2001.03061.x.

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42

Sehgal, Pravinkumar B. "Interleukin-6: Molecular Pathophysiology". Journal of Investigative Dermatology 94, n.º 6 (junho de 1990): s2—s6. http://dx.doi.org/10.1111/1523-1747.ep12874963.

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43

Van Snick, Jacques. "Interleukin-6: An Overview". Annual Review of Immunology 8, n.º 1 (abril de 1990): 253–78. http://dx.doi.org/10.1146/annurev.iy.08.040190.001345.

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44

Pedersen, Bente Klarlund, Adam Steensberg e Peter Schjerling. "Exercise and interleukin-6". Current Opinion in Hematology 8, n.º 3 (maio de 2001): 137–41. http://dx.doi.org/10.1097/00062752-200105000-00002.

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45

Patarca, Roberto, e Mary Ann Fletcher. "Interleukin-6 and Disease". Journal of Chronic Fatigue Syndrome 4, n.º 1 (janeiro de 1998): 53–69. http://dx.doi.org/10.1300/j092v04n01_07.

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46

SEHGAL, PRAVIN B., LING WANG, RAVI RAYANADE, HENG PAN e LOLA MARGULIES. "Interleukin-6-Type Cytokinesa". Annals of the New York Academy of Sciences 762, n.º 1 (17 de dezembro de 2006): 1–14. http://dx.doi.org/10.1111/j.1749-6632.1995.tb32309.x.

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47

Mehra, Reena. "Soluble Interleukin 6 Receptor". Archives of Internal Medicine 166, n.º 16 (18 de setembro de 2006): 1725. http://dx.doi.org/10.1001/archinte.166.16.1725.

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48

Henkin, Robert I., Loren Schmidt e Irina Velicu. "Interleukin 6 in Hyposmia". JAMA Otolaryngology–Head & Neck Surgery 139, n.º 7 (1 de julho de 2013): 728. http://dx.doi.org/10.1001/jamaoto.2013.3392.

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49

Tesch, H., M. Jüjcler, S. Klein, H. Abts, A. Güjnther, G. R. F. Krueger e V. Diehl. "Hodgkin and Reed-Sternberg Cells Express Interleukin 6 and Interleukin 6 Receptors". Leukemia & Lymphoma 7, n.º 4 (janeiro de 1992): 297–303. http://dx.doi.org/10.3109/10428199209049781.

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Peters, Malte, Guido Blinn, Thomas Jostock, Peter Schirmacher, Karl–Hermann Meyer Zum Büschenfelde, Peter R. Galle e Stefan Rose–John. "Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration". Gastroenterology 119, n.º 6 (dezembro de 2000): 1663–71. http://dx.doi.org/10.1053/gast.2000.20236.

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Artigos de revistas sobre o tema "Interleukin-6"

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