Teses / dissertações sobre o tema "Immune signalling"
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Moon, Alice E. "Immune signalling in insect cells". Thesis, Kingston University, 2009. http://eprints.kingston.ac.uk/20407/.
Texto completo da fonteNg, Siaw Wei. "Calcium signalling in immune cells". Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b3843e43-9503-4855-a280-35c0d28f65e6.
Texto completo da fonteHamer, Rebecca K. "The structural basis of immune receptor signalling". Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:32312040-2e22-4fe3-b05e-6f868233e27e.
Texto completo da fonteAkha, Amir Akbar Sadighi. "Signalling through the B lymphocyte antigen receptor". Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318620.
Texto completo da fonteMorris-Davies, A. C. "Functional analysis of poly-ubiquitin chains in immune signalling". Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1383788/.
Texto completo da fonteDawson, Charlotte Helen. "STAT 6 and IL-4 signalling". Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245716.
Texto completo da fonteSilva, Couto Daniel. "Regulation of receptor kinase-mediated immune signalling by dynamic phosphorylation". Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/59391/.
Texto completo da fonteWahl, Karen. "Role of Notch signalling in the induction of immune responses". Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23239.
Texto completo da fonteBeyers, Albertus Daniel. "Transmembrane signalling by the CD2 and CD4 molecules of T lymphocytes". Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291324.
Texto completo da fonteWatkinson, Ruth Elizabeth. "Intracellular antibody receptor TRIM21 in viral neutralisation and innate immune signalling". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708305.
Texto completo da fonteRieser, Eva. "The role of HOIL-1, HOIP and SHARPIN in immune signalling". Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/17941.
Texto completo da fonteWyszynski, Rafal Wlodzimierz. "Differential control of immune cell function by HIF-1 signalling pathway". Thesis, University of Kent, 2014. https://kar.kent.ac.uk/47691/.
Texto completo da fonteMurray, James. "PI 3-kinase : a key effector in C-FMS signalling". Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264478.
Texto completo da fonteSchreuder, Lisa Jane. "Effects of Mycrobacteria on the Signalling Machinenary of Bovine Innate Immune Cells". Thesis, Royal Veterinary College (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499275.
Texto completo da fonteBanham-Hall, Edward James. "The role of p110[delta] signalling in immune defence against Streptococcus pneumoniae". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708138.
Texto completo da fonteSmith, Emma Marie. "Studies on the role of notch signalling in the adult peripheral immune system". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497290.
Texto completo da fonteRoberts, Luke Bryan. "The influence of non-neuronal cholinergic signalling on the type 2 immune response". Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/56913.
Texto completo da fonteJan, Afnan. "A role for connexin signalling in the innate immune response in the skin". Thesis, Glasgow Caledonian University, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.726766.
Texto completo da fonteBhandage, Amol K. "Glutamate and GABA signalling components in the human brain and in immune cells". Doctoral thesis, Uppsala universitet, Fysiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282422.
Texto completo da fonteLo, Yu-Lan (Sandra). "Alternatively Spliced Forms of Tollip Regulate Inflammatory Signalling in Macrophages". Thesis, Griffith University, 2012. http://hdl.handle.net/10072/366923.
Texto completo da fonteThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Science, Environment, Engineering and Technology
Full Text
Shweash, Muhannad Abdulmajeed Muhammad. "The pathological effects of Leishmania mexicana infection on macrophage cell signalling and immune responses". Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=14478.
Texto completo da fonteFuseya, Yasuhiro. "The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC". Kyoto University, 2020. http://hdl.handle.net/2433/259006.
Texto completo da fonteKouroumalis, Andreas. "Characterization of immune receptor-cognate ligands expression and signalling pathways in human intestinal myofibroblasts". Thesis, University of Bath, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405156.
Texto completo da fonteBilkei-Gorzo, Orsolya. "Ubiquitylation regulates vesicle trafficking and innate immune responses on the phagosome of inflammatory macrophages". Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/8661922d-9d5e-4a4a-bfd4-b0f5e5717c61.
Texto completo da fonteAyyar, Priya Vijay. "Uncovering the role of S-nitrosylation in jasmonic acid signalling during the plant immune response". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25783.
Texto completo da fonteBolukbasi, Ekin. "Characterization of Poly : a novel mediator of insulin receptor signalling in Drosophila". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5700.
Texto completo da fonteGhaffari, Emma Louise Marie. "Early growth response genes -2 and -3 are essential for optimal immune responses". Thesis, Brunel University, 2013. http://bura.brunel.ac.uk/handle/2438/8134.
Texto completo da fonteSotsios, Yannis. "Chemokines and T cells : activation requirements for RANTES secretion and CXCR4 signalling in mature T cells". Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323606.
Texto completo da fonteEhrenberg, Stefanie [Verfasser], e Josef [Akademischer Betreuer] Mautner. "Notch2 signalling in B cell activation, immune response and lymphomagenesis / Stefanie Ehrenberg. Betreuer: Josef Mautner". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1096162849/34.
Texto completo da fonteCheng, Xiaoxiao. "The nature of protein interactions mediating co-stimulatory signalling in the immune system, involving PD-1". Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600227.
Texto completo da fonteGaughan, Daniel. "The role of DNA damage response proteins in innate immune signalling : a new role for BRCA1". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:252f589f-40c0-4f7f-be3d-124e588e92a8.
Texto completo da fonteThoma, Martine. "Role of IkappaB/NF-kappaB signalling pathways in the immune response of the mosquito Anopheles gambiae". Strasbourg, 2009. https://publication-theses.unistra.fr/restreint/theses_doctorat/2009/THOMA_Martine_2009.pdf.
Texto completo da fonteElsheikh, Ayman A. "Drug immunogenicity and co-stimulatory signalling : evidence for formation of a functional antigen through immune cell metabolism". Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548759.
Texto completo da fonteBielig, Harald Frank Verfasser], Jonathan [Akademischer Betreuer] Howard e Mats [Akademischer Betreuer] [Paulsson. "Screening for components involved in NLR-mediated immune signalling / Harald Frank Bielig. Gutachter: Jonathan Howard ; Mats Paulsson". Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038226805/34.
Texto completo da fonteBielig, Harald Frank [Verfasser], Jonathan Akademischer Betreuer] Howard e Mats [Akademischer Betreuer] [Paulsson. "Screening for components involved in NLR-mediated immune signalling / Harald Frank Bielig. Gutachter: Jonathan Howard ; Mats Paulsson". Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038226805/34.
Texto completo da fonteKarsten, Elisabeth. "Red blood cells: the immune system’s hidden regulator, investigation into the role of red blood cells in inflammatory cytokine signalling". Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16929.
Texto completo da fonteFlorey, Oliver John. "Effects of anti-endothlial cell antibodies, immune-complexes and sphingosine-1-phosphate on leukocyte adhesion and cell signalling". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498233.
Texto completo da fonteWeber, Sabine [Verfasser], e Daniela [Akademischer Betreuer] Männel. "Effects of TNF Receptor Signalling on the the Function of Suppressive Immune Cells / Sabine Weber. Betreuer: Daniela Männel". Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1096751755/34.
Texto completo da fonteHomem, Rafael Augusto. "Redox signalling and innate immunity : a role for protein S-nitrosylation in the immune response of Drosophila melanogaster". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/15971.
Texto completo da fonteReder, Gabor. "Development of a phosphoproteomic screen of innate immune signalling : identification and characterisation of a novel phosphorylation of NFkB1/p105". Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6150.
Texto completo da fonteARTUSA, VALENTINA. "Modulation of the Innate Immune Response by Targeting Toll-like Receptor 4 Signalling: Exploring the Role of Natural Products". Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/375443.
Texto completo da fonteFor centuries, natural products and their derivatives have provided a rich source of compounds for the development of new immunomodulators in the treatment of human diseases. Natural immune modulators may provide the key to control and ultimately defeat disorders affecting the immune system, by either up- or down-regulating the immune response with few adverse side effects. Many of these compounds are currently undergoing clinical trials, particularly as anti-oxidative, anti-microbial, and anti-cancer agents. However, the functions and mechanisms of action of natural products, and how they interact with the immune system, has yet to be extensively explored. In recent years, the increasing body of knowledge regarding the role of macrophages in the steady-state and in the context of inflammation has opened diverse new avenues of investigation and possibilities for therapeutic intervention targeting the inherent plasticity of macrophages for the treatment of acute and chronic inflammatory disease. Toll-Like Receptors (TLRs), including TLR4, play a crucial role in inflammatory-based diseases, therefore TLR4 signalling has been identified as a therapeutic target for pharmacological intervention. This work aims to screen and investigate the potential of phytoextracts and phytochemicals to affect TLR4 signalling in a macrophage-like cell model. Specifically, extracts from green (GCE) and roasted (RCE) coffee beans as well as pure chlorogenic acid (5-CQA) were tested. Also, the anti-inflammatory effect of palmitoylethanolamide (PEA), and its synthetic analogue RePEA, was assessed. Human monocyte-derived macrophages, deriving from the differentiation of a monocytic cell line (THP-1) and/or from human primary CD14+ monocytes, were employed as an in vitro model. MTT was used to determine cytotoxic effects of the treatments. TLR4 activation was stimulated by exposure of cells to bacterial endotoxin LPS (E. coli), in presence or absence of treatments. Different readouts were evaluated: endpoint pro-inflammatory cytokines production, as well as phosphorylation and nuclear translocation of intracellular signalling mediators. These parameters were measured applying different cellular and molecular techniques, mainly enzyme-linked immunosorbent assay (ELISA), High Content Analysis (immunofluorescence microscopy), and Western blot. Alongside, we employed different commercially available stable transfected cells as tools to investigate the mechanism of action of our tested extract or molecule, THP1-XBlue™, RAW-Blue™ and HEK-Blue™ cells, respectively. Key findings include a dramatic, dose-dependent, inhibitory effect of both green and roasted coffee extracts towards interferon-β (IFN-β) release, upon LPS stimulation. Consistently, chlorogenic acid, a major polyphenolic component of coffee extracts, showed a comparable biological activity. Additionally, novel evidence towards the immunomodulatory effects and mechanism of action of coffee extracts and chlorogenic acid as modulators of TLR4-related pro-inflammatory signalling have been provided. Alongside, PEA capability of reducing TNF-α release from LPS-stimulated microglial cells, was corroborated in our macrophage model also, confirming its anti-inflammatory potential. Moreover, RePEA, a synthetic PEA analogue designed to be degraded slower, was revealed to be more active than its parent compound. These experimental data demonstrate that natural products may act as lead molecules for the development of safe and effective immunomodulators. Taken together, these findings help to validate the above-mentioned natural molecules, 5-CQA and PEA, but also RePEA, as potential novel candidates for further preclinical investigations for the treatment of inflammatory-based disorders.
Ekholm, Dag. "Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune cells with special reference to phosphodiesterases PDE3 and PDE4". Lund : Lund University, 1998. http://books.google.com/books?id=KPFqAAAAMAAJ.
Texto completo da fonteKorir, Patricia Jebett [Verfasser]. "Immune regulation in Plasmodium berghei ANKA infected mice either lacking type I interferon signalling or mimicking malaria tolerance / Patricia Jebett Korir". Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1155825454/34.
Texto completo da fonteSidwaba, Unathi. "Electrochemical poly(ProDOT) dendritic DNA aptamer biosensor for signalling interferon gamma (IFN-ɣ) TB biomarker". University of the Western Cape, 2017. http://hdl.handle.net/11394/5507.
Texto completo da fonteTuberculosis (TB) is an infectious disease that, despite all efforts devoted towards its eradication, remains a threat to many countries including South Africa. Current diagnostic assays do offer better performance than the conventional sputum smear microscopy and tuberculin skin tests. However, these assays have been proven to be affected by various factors including the condition of an individual's immune system and vaccination history. By far, electrochemical biosensors are amongst the currently investigated techniques to address the shortcomings associated with these diagnostics.
2020-08-31
Anselm, Bettina [Verfasser], e Bianca [Akademischer Betreuer] Schaub. "Early priming of the immune system: Identifying predictive markers of innate immunity and calcium signalling for the development of asthma / Bettina Anselm ; Betreuer: Bianca Schaub". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1204827915/34.
Texto completo da fonteWestphal, Andreas [Verfasser], Kyeong-Hee [Akademischer Betreuer] Lee, Norbert [Akademischer Betreuer] Reiling e Georgios [Akademischer Betreuer] Tsiavaliaris. "Lysosomal trafficking regulator Lyst controls innate immune cell signalling and function : regulation of TLR-mediated TRIF signalling and control of mast cell-mediated allergic reactions / Andreas Westphal ; Akademische Betreuer: Kyeong-Hee Lee, Norbert Reiling, Georgios Tsiavaliaris ; Institut für Klinische Chemie". Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2017. http://d-nb.info/1143981758/34.
Texto completo da fonteKäbisch, Romy Astrid [Verfasser], Markus [Akademischer Betreuer] Gerhard e Dirk [Akademischer Betreuer] Haller. "Effect of Helicobacter pylori infection on dendritic cell maturation, signalling and subsequent adaptive immune response / Romy Astrid Käbisch. Gutachter: Dirk Haller ; Markus Gerhard. Betreuer: Markus Gerhard". München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1060482630/34.
Texto completo da fonteSistigu, Antonella. "Inflammatory and immune reactions in response to chemotherapy-induced cell death. Viral mimicry chemotherapy : ds RNA sensors and IFNAR signalling indispensable for immunogenic tumor cell death". Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T052.
Texto completo da fonteDistinct cell death-associated molecular patterns might define cancers proned to respond to a cytotoxic therapy by mounting a protective T cell-based anticancer immunity. My PhD Thesis work shows that immunogenic chemotherapy phenocopies viral infection leading to autocrine IFNαβ/IFNAR1/2 signalling in tumor cells initiated by recognition of self dsRNA by endosomal pattern recognition receptors (PRRs). In detail, TLR3/TRIF (endosomal dsRNA sensors) and IFNAR1/2 (Type I IFN receptors) must signal within the tumor cells so that chemotherapy can induce downstream CXCL10/CXCR3 axis and elicit therapeutic responsiveness in vivo. RNA profiling of Tlr3+/+ (but not Tlr3-/-) tumor cells exposed to anthracyclines revealed a strong IFN/viral fingerprint, indispensable for the tumoricidal activity. Neutralization by antibodies or genetic defects affecting tumor –associated TLR3 or IFNAR1/2 compromised chemotherapy-induced CXCL10 release and tumor control unless exogenous IFNαβ or CXCL10 are concomitantly supplied to anthracyclines. Moreover, chemoresistance of tumors treated by drugs failing to induce a viral signature can be reversed by exogenous Type I IFN. Finally, the IFN fingerprint of human breast cancers allowed to predict tumors proned to benefit from adjuvant anthracyclines. From an evolutionary viewpoint, while tumors (like viruses) have evolved mechanisms to evade an IFN response, chemotherapy-induced viral mimicry might contribute to bypass such as immunoediting
Lambourne, Jonathan Richard. "An investigation of human immune signalling pathways during Staphylococcus aureus colonisation and bacteraemia leading to an investigation of mannose-binding lectin in S. aureus bacteraemia, chronic hepatitis and acute aspergillosis". Thesis, St George's, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546773.
Texto completo da fonteZmarlak, Natalia Marta. "Regulation of immune signalling in the malaria mosquito vector, Anopheles : the secreted mosquito leucine-rich repeat protein APL1C is a pathogen binding factor essential for immunity to Plasmodium ookinetes and sporozoites". Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS053.
Texto completo da fonteAnopheles mosquito is a vector of Plasmodium parasite, the causative agent of malaria. The Anopheles leucine-rich repeat (LRR) proteins were described as key antagonists of Plasmodium parasites in Anopheles mosquito midgut. APL1C (Anopheles Plasmodium-responsive factor) is a representative of LRR members which specifically protects against rodent malaria parasites by stabilizing the complement-like protein TEP1. By combining cell biology with functional genomic approaches, this study shows that mosquito bloodmeal induce the presence of an extracellular layer of APL1C protein surrounding the midgut beneath of the basal lamina. Consistently with the formation of this layer, APL1C binds to the ookinetes that emerged on the basal side of the midgut. This presence occurs independently from TEP1 function, requires the contribution of the phagocytic cells and nitration pathway. In addition, APL1C defence function is not restricted to the ookinete in the midgut but it also acts against the latest Plasmodium stage, the sporozoites. APL1C inhibits salivary glands infection prevalence, and consistently, it also binds to the surface of the sporozoites in the hemocoel. However, unlike to the midgut stages, anti-sporozoites APL1C-dependent mechanism involves different partners. Moreover, RNAseq study revealed APL1C gene targets, including genes with immune-like function. These results generate novel biological insight for the function of APL1C, and probably other LRR family members, as a pathogen recognition receptor inducing immune response against pathogens that come in contact with mosquito hemolymph compartment