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Bibliografias temáticas / Imaging systems in medicine

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Literatura científica selecionada sobre o tema "Imaging systems in medicine"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 29 de julho de 2024

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Artigos de revistas sobre o assunto "Imaging systems in medicine"

1

Foppen, Wouter, Nelleke Tolboom e Pim A. de Jong. "Systems Radiology and Personalized Medicine". Journal of Personalized Medicine 11, n.º 8 (4 de agosto de 2021): 769. http://dx.doi.org/10.3390/jpm11080769.

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Hacker, Marcus, Rodney J. Hicks e Thomas Beyer. "Applied Systems Biology—embracing molecular imaging for systemic medicine". European Journal of Nuclear Medicine and Molecular Imaging 47, n.º 12 (7 de abril de 2020): 2721–25. http://dx.doi.org/10.1007/s00259-020-04798-8.

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Line, Bruce R. "Nuclear medicine information management systems". Seminars in Nuclear Medicine 20, n.º 3 (julho de 1990): 242–69. http://dx.doi.org/10.1016/s0001-2998(05)80033-9.

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4

Zaidi, Habib. "Multimodality molecular imaging: Paving the way for personalized medicine". Medical Technologies Journal 1, n.º 3 (17 de setembro de 2017): 44. http://dx.doi.org/10.26415/2572-004x-vol1iss3p44-46.

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Early diagnosis and therapy increasingly operate at the cellular, molecular or even at the genetic level. As diagnostic techniques transition from the systems to the molecular level, the role of multimodality molecular imaging becomes increasingly important. Positron emission tomography (PET), x-ray CT and MRI are powerful techniques for in vivo imaging. The inability of PET to provide anatomical information is a major limitation of standalone PET systems. Combining PET and CT proved to be clinically relevant and successfully reduced this limitation by providing the anatomical information required for localization of metabolic abnormalities. However, this technology still lacks the excellent soft-tissue contrast provided by MRI. Standalone MRI systems reveal structure and function, but cannot provide insight into the physiology and/or the pathology at the molecular level. The combination of PET and MRI, enabling truly simultaneous acquisition, bridges the gap between molecular and systems diagnosis. MRI and PET offer richly complementary functionality and sensitivity; fusion into a combined system offering simultaneous acquisition will capitalize the strengths of each, providing a hybrid technology that is greatly superior to the sum of its parts. This talk also reflects the tremendous increase in interest in quantitative molecular imaging using PET as both clinical and research imaging modality in the past decade. It offers a brief overview of the entire range of quantitative PET imaging from basic principles to various steps required for obtaining quantitatively accurate data from dedicated standalone PET and combined PET/CT and PET/MR systems including algorithms used to correct for physical degrading factors and to quantify tracer uptake and volume for radiation therapy treatment planning. Future opportunities and the challenges facing the adoption of multimodality imaging technologies and their role in biomedical research will also be addressed.

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Stephane Mananga, Eugene. "Recent Advances of Radiation Detector Systems in Nuclear Medicine Imaging". JOURNAL OF BIOINFORMATICS AND PROTEOMICS REVIEW 2, n.º 2 (2016): 169–71. http://dx.doi.org/10.15436/2381-0793.16.1183.

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Lewellen, Tom K., Don DeWitt, Robert S. Miyaoka e Scott Hauck. "A Building Block for Nuclear Medicine Imaging Systems Data Acquisition". IEEE Transactions on Nuclear Science 61, n.º 1 (fevereiro de 2014): 79–87. http://dx.doi.org/10.1109/tns.2013.2295037.

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Lee, Daniel Y., e King C. P. Li. "Systems Diagnostics: The Systems Approach to Molecular Imaging". American Journal of Roentgenology 193, n.º 2 (agosto de 2009): 287–94. http://dx.doi.org/10.2214/ajr.09.2866.

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Duby, Tomas, Noam Kaplan e Yuval Zur. "4749948 NMR imaging systems". Magnetic Resonance Imaging 7, n.º 4 (julho de 1989): VI—VII. http://dx.doi.org/10.1016/0730-725x(89)90516-x.

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&NA;. "3M DryView Laser Imaging Systems". Investigative Radiology 31, n.º 6 (junho de 1996): 385. http://dx.doi.org/10.1097/00004424-199606000-00015.

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Sivananthan, U. M. "Medical imaging systems techniques and applications; cardiovascular systems". Radiography 5, n.º 2 (maio de 1999): 120. http://dx.doi.org/10.1016/s1078-8174(99)90044-5.

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Teses / dissertações sobre o assunto "Imaging systems in medicine"

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Nadeau, Valerie J. "Fluorescence imaging and spectroscopy systems for cancer diagnostics". Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269513.

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Raichur, Rohan. "A novel technique to improve the resolution & contrast of planar nuclear medicine imaging". Akron, OH : University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1226955205.

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Thesis (M.S.)--University of Akron, Dept. of Biomedical Engineering, 2008.
"December, 2008." Title from electronic thesis title page (viewed 12/13/2009) Advisor, Dale H. Mugler; Co-Advisor, Anthony M. Passalaqua; Committee members, Daniel B. Sheffer; Department Chair, Daniel B. Sheffer; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.

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Dhillon, Ravinder. "Diagnostic imaging pathways /". Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0126.

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Pao, Tsang-Long. "Ultrasonic tapered phased arrays for three-dimensional imaging". Diss., Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/13541.

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Eljaaidi, Abdalla Agila. "2D & 3D ultrasound systems in development of medical imaging technology". Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2193.

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Thesis (MTech (Electrical Engineering))--Cape Peninsula University of Technology, 2016.
Ultrasound is widely used in most medical clinics, especially obstetrical clinics. It is a way of imaging methods that has important diagnostic value. Although useful in many different applications, diagnostic ultrasound is especially useful in antenatal (before delivery) diagnosis. The use of two-dimensional ultrasound (2DUS) in obstetrics has been established. However, there are many disadvantages of 2DUS imaging. Several researchers have published information on the significance of patients being shown the ultrasound screen during examination, especially during three- and four-dimensional (3D/4D) scanning. In addition, a form of ultrasound, called keepsake or entertainment ultrasound, has boomed, particularly in the United States. However, long-term epidemiological studies have failed to show the adverse effects of ultrasound in human tissues. Until now, there is no proof that diagnostic ultrasound causes harm in a human body or the developing foetus when used correctly. While ultrasound is supposed to be absolutely safe, it is a form of energy and, as such, has effects on tissues it traverses (bio-effects). The two most important mechanisms for effects are thermal and non-thermal. These two mechanisms are indicated on the screen of ultrasound devices by two indices: The thermal index (TI) and the mechanical index (MI). These are the purposes of this thesis: • evaluate end-users’ knowledge regarding the safety of ultrasound; • evaluate and make a comparison between acoustic output indices (AOI) in B-mode (2D) and three-dimensional (3D) ultrasound – those measured by thermal (TI) and mechanical (MI) indices; • assess the acoustic output indices (AOI) to benchmark current practice with a survey conducted by the British Medical Ultrasound Society (BMUS); and • review how to design 2D and 3D arrays for medical ultrasound imaging

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Wild, Walter James. "Gamma-ray imaging probes". Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184331.

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External nuclear medicine diagnostic imaging of early primary and metastatic lung cancer tumors is difficult due to the poor sensitivity and resolution of existing gamma cameras. Nonimaging counting detectors used for internal tumor detection give ambiguous results because distant background variations are difficult to discriminate from neighboring tumor sites. This suggests that an internal imaging nuclear medicine probe, particularly an esophageal probe, may be advantageously used to detect small tumors because of the ability to discriminate against background variations and the capability to get close to sites neighboring the esophagus. The design, theory of operation, preliminary bench tests, characterization of noise behavior and optimization of such an imaging probe is the central theme of this work. The central concept lies in the representation of the aperture shell by a sequence of binary digits. This, coupled with the mode of operation which is data encoding within an axial slice of space, leads to the fundamental imaging equation in which the coding operation is conveniently described by a circulant matrix operator. The coding/decoding process is a classic coded-aperture problem, and various estimators to achieve decoding are discussed. Some estimators require a priori information about the object (or object class) being imaged; the only unbiased estimator that does not impose this requirement is the simple inverse-matrix operator. The effects of noise on the estimate (or reconstruction) is discussed for general noise models and various codes/decoding operators. The choice of an optimal aperture for detector count times of clinical relevance is examined using a statistical class-separability formalism.

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Zhu, Hui. "Deformable models and their applications in medical image processing /". Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20717970.

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Liew, Soo Chin. "Thermoacoustic emission induced by deeply penetrating radiation and its application to biomedical imaging". Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184783.

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Thermoacoustic emissions induced by 2450 MHz microwave pulses in water, tissue-simulating phantoms and dog kidneys have been detected. The analytic signal magnitude has been employed in generating 'A-mode' images with excellent depth resolution. Thermoacoustic emissions have also been detected from the dose-gradient at the beam edges of a 4 MeV x-ray beam in water. These results establish the feasibility of employing thermoacoustic signals in generating diagnostic images, and in locating x-ray beam edges during radiation therapy. A theoretical model for thermoacoustic imaging using a directional transducer has been developed, which may be used in the design of future thermoacoustic imaging system, and in facilitating comparisons with other types of imaging systems. A method of characterizing biological tissues has been proposed, which relates the power spectrum of the detected thermoacoustic signals to the autocorrelation function of the thermoacoustic source distribution in the tissues. The temperature dependence of acoustic signals induced by microwave pulses in water has been investigated. The signal amplitudes vary with temperature as the thermal expansion of water, except near 4°C. The signal waveforms show a gradual phase change as the temperature changes from below 4° to above 4°C. This anomaly is due to the presence of a nonthermal component detected near 4°C, whose waveform is similar to the derivative of the room temperature signal. The results are compared to a model based on a nonequilibrium relaxation mechanism proposed by Pierce and Hsieh. The relaxation time was found to be (0.20±0.02) ns and (0.13±0.02) ns for 200 ns and 400 ns microwave pulse widths, respectively. A microwave-induced thermoacoustic source capable of launching large aperture, unipolar ultrasonic plane wave pulses in water has been constructed. This source consists of a thin water layer trapped between two dielectric media. Due to the large mismatch in the dielectric constants, the incident microwaves undergo multiple reflections between the dielectric boundaries trapping the water, resulting in an enhanced specific microwave absorption in the thin water layer. This source may be useful in ultrasonic scattering and attenuation experiments.

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Jin, Jiefu, e 金介夫. "Functional lanthanide-based nanoprobes for biomedical imaging applications". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47752579.

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Lanthanide-doped upconversion nanoparticles (UCNPs) are perceived as promising novel near-infrared (NIR) bioimaging agents characterised by high contrast and high penetration depth. However, the interactions between charged UCNPs and mammalian cells have not been thoroughly studied and the corresponding intracellular uptake pathways remain unclear. Herein, my research work involved the use of hydrothermal method and ligand exchange approach to prepare UCNP-PVP, UCNP-PEI, and UCNP-PAA. These polymer-coated UCNPs demonstrated good water dispersibility, the similar size distribution as well as similar upconversion luminescence efficiency. However, the positively charged UCNP-PEI evinced greatly enhanced cellular uptake in comparison with its neutral or negative counterparts, as revealed by cellular uptake studies. Meanwhile, it was discovered that cationic UCNP-PEI could be effectively internalized mainly through the clathrin endocytic machanism. This study is the first report on the endocytic mechanism of positively charged lanthanide-doped UCNPs. Furthermore, it allows us to control the UCNP-cell interactions by tuning surface properties. Glioblastoma multiforme (GBM) is the most common and malignant form of primary brain tumors in humans. Small molecule MRI contrast agents are used for GBM diagnosis and preoperative tumor margin delineation. However, the conventional gadolinium-based contrast agents have several disadvantages, such as a relatively low T1 relaxivity, short circulation half lives and the absence of tumor targeting efficiency. Multimodality imaging probes provide a better solution to clearly delineate the localization of glioblastoma. My research work also involved the development of multimodal nanoprobes for targeted glioblastoma imaging. Two targeted paramagnetic/fluorescence nanoprobes were designed and synthesized, UCNP-Gd-RGD and AuNP-Dy680-Gd-RGD. UCNP-Gd-RGD was prepared through PEGylation, Gd3+DOTA conjugation and RGD labeling of PEI-coated UCNP-based nanoprobe core (UCNP-NH2). It adopted the cubic NaYF4 phase, had an average size of 36 nm by TEM, and possessed a relatively intense upconversion luminescence of Er3+ and Tm3+. It also exhibited improved colloidal stability and reduced cytotoxicity compared with UCNP-NH2, and a higher T1 relaxivity than Gd3+DOTA. AuNP-Dy680-Gd-RGD was synthesized through bioconjugation of amine-modified AuNP-based nanoprobe core (AuNPPEG- NH2) by a NIR dye (Dy680), Gd3+DOTA and RGD peptide. It demonstrated a size of 3–6 nm by TEM, relatively strong NIR fluorescence centered at 708 nm, longterm physiological stability, and an enhanced T1 relaxivity compared with Gd3+DOTA. Targeting abilities of both UCNP-Gd-RGD and AuNP-Dy680-Gd-RGD towards overexpressed integrin αvβ3 receptors on U87MG cell surface was confirmed by their enhanced cellular uptake visualized by confocal microscopy imaging and quantified by ICP-MS, where their corresponding control nanoprobes were used for comparison. Furthermore, targeted imaging capabilities of UCNP-Gd-RGD and AuNP-Dy680-Gd- RGD towards subcutaneous U87MG tumors were verified by in vivo and ex vivo upconversion fluorescence imaging studies and by in vivo and ex vivo NIR fluorescence imaging and in vivo MR imaging studies, respectively. These two synthesized targeted nanoprobes, with surface-bounded cyclic RGD peptide and numerous T1 contrast enhancing molecules, are applicable in targeted MR imaging glioblastoma and delineating the tumor boundary. In addition, UCNP-Gd-RGD favors the upconversion luminescence with NIR-to-visible nature, while AuNPDy680- Gd-RGD possesses NIR-to-NIR fluorescence, and both lead to their potential applications in fluorescence-guided surgical resection of gliomas.
published_or_final_version
Chemistry
Doctoral
Doctor of Philosophy

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Futterer, Patricia. "Cultural studies of science : skinning bodies in Western medicine". Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23332.

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This thesis explores the cultural implications underlying the medical practice of cutting human flesh. The examination focuses, in particular, on the function of representational technologies--from anatomy sketches to computer imaging--in the scientific understanding of the body in the West. By foregrounding the technologies of representation which inform and have directed a history of surgery, it is hoped that the cultural aspects of modern medicine will be made apparent. This thesis argues that while science benefitted from art to construct its image of 'the' body, it has had to rid itself of art in order to justify its empirical claims. The study concludes with a discussion of the work of the French performance artist Orlan who uses plastic surgery in a performative setting to deconstruct these very claims.

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Livros sobre o assunto "Imaging systems in medicine"

1

Höhne, Karl Heinz. 3D Imaging in Medicine: Algorithms, Systems, Applications. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990.

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2

1937-, Höhne K. H., Fuchs Henry 1948-, Pizer Stephen M e North Atlantic Organization. Scientific Affairs Division., eds. 3D imaging in medicine: Algorithms, systems, applications. Berlin: Springer-Verlag, 1990.

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3

Singh, B. Display of nuclear medicine imaging studies. Mumbai: Bhabha Atomic Research Centre, 2002.

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4

1920-, Hayaishi Osamu, Torizuka Kanji 1926- e Takeda Science Foundation Symposium on Bioscience (3rd : 1984 : Kyoto, Japan), eds. Biomedical imaging. Tokyo: Academic Press, 1986.

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5

G, Fujimoto James, e Farkas Daniel L, eds. Biomedical optical imaging. Oxford: Oxford University Press, 2008.

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6

Sharp, Peter F. Radionuclide imaging techniques. London: Academic Press, 1985.

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7

L, Kundel Harold, Society of Photo-optical Instrumentation Engineers. e American Association of Physicists in Medicine., eds. Medical imaging 1996. Bellingham, Wash., USA: SPIE, 1996.

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V, Dimmer, Herrmann W. R e Kunze Klaus Dietmar, eds. Automated image analysis in medicine and biology: Proceedings. Leipzig: Barth, 1988.

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9

Forum, Welsh Health Planning, ed. Effectiveness in medical imaging. [Cardiff]: Welsh Health Planning Forum, 1994.

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10

Agaian, S. S., Jinshan Tang e Jindong Tan. Mobile imaging in healthcare. Bellingham, Washington: SPIE Press, 2016.

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Capítulos de livros sobre o assunto "Imaging systems in medicine"

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de la Zerda, Adam. "Photoacoustic Imaging: Development of Imaging Systems and Molecular Agents". In Engineering in Translational Medicine, 799–833. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4372-7_29.

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Dahlbom, Magnus. "Preclinical Molecular Imaging Systems". In Handbook of Nuclear Medicine and Molecular Imaging for Physicists, 515–32. New York: CRC Press, 2021. http://dx.doi.org/10.1201/9780429489556-28.

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Brennecke, Rüdiger. "Digital imaging systems for coronary angiography". In Developments in Cardiovascular Medicine, 1–12. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-009-1309-7_1.

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4

Fuchs, Henry. "Systems for Display of Three-Dimensional Medical Image Data". In 3D Imaging in Medicine, 315–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-84211-5_21.

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Pizer, Stephen M. "Systems for 3D Display in Medical Imaging". In Pictorial Information Systems in Medicine, 235–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-82384-8_7.

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Saijo, Y., N. Hozumi, K. Kobayashi, N. Okada, Y. Hagiwara, H. Sasaki, E. d. S. Filho e T. Yambe. "Ultrasonic Nano-Imaging System for Medicine and Biology". In Acoustical Imaging, 181–86. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-8823-0_25.

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Dickson, John. "Quality Assurance of Nuclear Medicine Systems". In Handbook of Nuclear Medicine and Molecular Imaging for Physicists, 427–53. New York: CRC Press, 2021. http://dx.doi.org/10.1201/9780429489556-23.

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Goeringer, Fred. "Medical Diagnostic Imaging Support Systems for Military Medicine". In Picture Archiving and Communication Systems (PACS) in Medicine, 213–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76566-7_26.

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Sarrut, David, e Michael Ljungberg. "Monte Carlo Simulation of Nuclear Medicine Imaging Systems". In Handbook of Nuclear Medicine and Molecular Imaging for Physicists, 533–61. New York: CRC Press, 2021. http://dx.doi.org/10.1201/9780429489556-29.

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Bauman, Roger A. "The Future of Digital Computers in Medical Imaging". In Pictorial Information Systems in Medicine, 381–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-82384-8_14.

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Trabalhos de conferências sobre o assunto "Imaging systems in medicine"

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Sokol, Yevgen, Oleg Avrunin, Kostyantyn Kolisnyk e Petro Zamiatin. "Using Medical Imaging in Disaster Medicine". In 2020 IEEE 4th International Conference on Intelligent Energy and Power Systems (IEPS). IEEE, 2020. http://dx.doi.org/10.1109/ieps51250.2020.9263175.

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Goeringer, Fred. "Medical diagnostic imaging support systems for military medicine". In Medical Imaging '91, San Jose, CA, editado por Yongmin Kim. SPIE, 1991. http://dx.doi.org/10.1117/12.45185.

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3

Radetzky, Arne, Andreas Nuernberger e Dietrich P. Pretschner. "Simulation of elastic tissues in virtual medicine using neuro-fuzzy systems". In Medical Imaging '98, editado por Yongmin Kim e Seong K. Mun. SPIE, 1998. http://dx.doi.org/10.1117/12.312516.

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4

Smutek, D., A. Shimizu, L. Tesar, H. Kobatake, S. Nawano e S. Svacina. "Automatic Internal Medicine Diagnostics Using Statistical Imaging Methods". In Proceedings. 19th IEEE International Symposium on Computer-Based Medical Systems. IEEE, 2006. http://dx.doi.org/10.1109/cbms.2006.56.

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Takeda, Kanako, Toshiya Nakaguchi, Takeshi Oji e Takao Namiki. "A basic study of tongue angle detection method for tongue diagnosis assistance in Kampo medicine". In Imaging Systems and Applications. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/isa.2013.iw2e.1.

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Slomka, Piotr J., Edward Elliott e Albert A. Driedger. "Java-based PACS and reporting system for nuclear medicine". In Medical Imaging 2000, editado por G. James Blaine e Eliot L. Siegel. SPIE, 2000. http://dx.doi.org/10.1117/12.386409.

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Lewellen, Tom K., Don DeWitt, Robert S. Miyaoka e Scott Hauck. "A building block for nuclear medicine imaging systems data acquisition". In 2012 IEEE-NPSS Real Time Conference (RT 2012). IEEE, 2012. http://dx.doi.org/10.1109/rtc.2012.6418199.

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Ottes, Fenno P., Albert R. Bakker, Chel VanGennip, Bas M. van Poppel, Pieter J. Toussaint, Ruud Weber e Onno Weier. "Overall system design of a PACS for nuclear medicine images". In Medical Imaging 1996, editado por R. Gilbert Jost e Samuel J. Dwyer III. SPIE, 1996. http://dx.doi.org/10.1117/12.239292.

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Loudos, George K., Carlos Granja, Claude Leroy e Ivan Stekl. "Advances in Small Animal Imaging Systems". In Nuclear Physics Medthods and Accelerators in Biology and Medicine. AIP, 2007. http://dx.doi.org/10.1063/1.2825762.

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Talat, Didar, Sinem Balta Beylergil e Albert Guvenis. "Optimal experimentation for nuclear medicine imaging system design". In 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference (2012 NSS/MIC). IEEE, 2012. http://dx.doi.org/10.1109/nssmic.2012.6551615.

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Relatórios de organizações sobre o assunto "Imaging systems in medicine"

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FDG-PET/CT SUV for Response to Cancer Therapy, Clinically Feasible Profile. Chair Nathan Hall e Jeffrey Yap. Radiological Society of North America (RSNA) / Quantitative Imaging Biomarkers Alliance (QIBA), junho de 2023. http://dx.doi.org/10.1148/qiba/20230615.

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This QIBA Profile documents specifications and requirements to provide comparability and consistency for quantitative FDG-PET across scanners in oncology. It can be applied to both clinical trial use as well as individual patient management. This document organizes acquisition, reconstruction and post-processing, analysis and interpretation as steps in a pipeline that transforms data to information to knowledge. The document, developed through the efforts of the QIBA FDG-PET Biomarker Committee, has shared content with the FDG-PET UPICT protocol, as well as additional material focused on the devices used to acquire and analyze the FDG-PET data. The QIBA acquisition protocol is largely derived from the FDG-PET UPICT protocol for FDG-PET imaging in clinical trials. In the UPICT protocol, there is a carefully developed hierarchy with tiered levels of protocol compliance. This reflects the recognition that there are valid reasons to perform trials using different levels of rigor, even for the same disease/intervention combination. For example, a high level of image measurement precision may be needed in small, early-phase trials whereas a less rigorous level of precision may be acceptable in large, late-phase trials of the same drug in the same disease setting. This Profile defines the behavioral performance levels and quality control specifications for whole-body FDG-PET/CT scans used in single- and multi-center clinical trials of oncologic therapies. While the emphasis is on clinical trials, this process is also intended to apply for clinical practice. The specific claims for accuracy are detailed in the Claims section. A motivation for the development of this Profile is that while a typical PET/CT scanner measurement system (including all supporting devices) may be stable over days or weeks, this stability cannot be expected over the time that it takes to complete a clinical trial. In addition, there are well known differences between scanners and or the operation of the same type of scanner at different imaging sites. The intended audiences of this document include: Technical staff of software and device manufacturers who create products for this purpose Biopharmaceutical companies, oncologists, and clinical trial scientists designing trials with imaging endpoints Clinical research professionals Radiologists, nuclear medicine physicists, technologists, physicists and administrators at healthcare institutions (1) considering specifications for procuring new PET/CT equipment, (2) designing PET/CT acquisition protocols, (3) making quantitative measurements from PET/CT images Regulators, nuclear medicine physicians, oncologists, and others making decisions based on quantitative image measurements

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