Artigos de revistas: "IB12"

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Panigrahy, Rabi Narayan, Susanta Kumar Panda e Prabhakar Reddy Veerareddy. "FORMULATION AND IN VITRO EVALUATION OF COMBINED FLOATING-BIOADHESIVE TABLETS OF IMATINIB MESYLATE". International Journal of Pharmacy and Pharmaceutical Sciences 9, n.º 10 (1 de novembro de 2017): 27. http://dx.doi.org/10.22159/ijpps.2017v9i11.18894.

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Objective: Gastro retentive drug delivery system (GRDDS) pertaining to its attributes like gastric retention time and the extended drug release profile has significantly improved patient compliance. The objective of the present study is to formulate and evaluate a stomach-specific floating-bioadhesive tablet of imatinib mesylate for prolonged residence in the stomach in the treatment of gastrointestinal stromal tumors (GIST).Methods: All the tablets were prepared with hydroxypropylmethylcellulose (HPMC), guar gum, sodium alginate, and carbopol using direct compression technique. Physical characterization, in vitro dissolution, the mucoadhesive force along with data analysis was done on each tablet. Results: The pre-compression characteristics of powder mixtures found to be satisfactory for all formulation batches. The results of physical evaluation for all batches were complying with pharmacopeia specification. The swelling index for all formulation batches was approximately 100% after 8 hours. The bioadhesive force (mean ± SD) reported in a range of 0.05 ± 0.09 to 0.18 ± 0.06 N/m2. It was observed that the release rate of tablets was decreased when the viscosity and concentration of the polymer were increased. Formulation batches IB1, IB2, IB4, IB5, IB6, IB9, IB10, IB11, and IB13 follows Higuchi Matrix model kinetics; whereas IB3, IB7, IB8, and IB12 follows Korsmeyer- Peppas model kinetics.Conclusion: Formulation batch IB9 reported a considerable swelling index, floating behavior, more bioadhesive strength with uniform drug release pattern. Therefore formulation batch IB9 was selected as optimized batch and were kept for further evaluation studies.

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Litaiff, Eleilza de Castro, Wanderli Pedro Tadei, Jorge Ivan Rebelo Porto e Ila Maria de Aguiar Oliveira. "Analysis of toxicity on Bacillus sphaericus from amazonian soils to Anopheles darlingi and Culex quinquefasciatus larvae". Acta Amazonica 38, n.º 2 (2008): 255–62. http://dx.doi.org/10.1590/s0044-59672008000200008.

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Bioassays under laboratory conditions aiming to determine the larvicidal activity of Bacillus sphaericus were carried out on Anopheles darlingi and Culex quinquefasciatus. In order to estimate the toxicity through median lethal concentration (LC50) and the relative potency of the strains to B. sphaericus standard strain 2362, probit analysis was performed utilizing the POLO-PC program. The findings of LC50 pointed out high effectiveness on strains IB15 (0.040 ppm), IB19 and S1116 (0.048 ppm), IB16 (0.052 ppm) and S265 (0.057 ppm). Strain IB15 presented nearly 50% more potency than strain 2362 in bioassays conducted on A. darlingi. It was observed that IB16 and S1116 strains were the most powerful against C. quinquefasciatus, showing to be about 300-400% stronger than 2362 strain. The results show that laboratory conditioned evaluation can be an important way to select promising bacteria with entomopathogenic action on biolarvicides production for use on mosquitoes breeding sites.

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Grisaru, Dan A., Allan Covens, Edmee Franssen, William Chapman, Patricia Shaw, Terence Colgan, Joan Murphy et al. "Histopathologic score predicts recurrence free survival after radical surgery in patients with stage IA2–IB12 cervical carcinoma". Cancer 97, n.º 8 (15 de abril de 2003): 1904–8. http://dx.doi.org/10.1002/cncr.11269.

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Park, Nae Yoon, Gun Oh Chong, Dae Gy Hong, Young Lae Cho, Il Soo Park e Yoon Soon Lee. "Oncologic Results and Surgical Morbidity of Laparoscopic Nerve-Sparing Radical Hysterectomy in the Treatment of FIGO Stage IB Cervical Cancer: Long-Term Follow-Up". International Journal of Gynecologic Cancer 21, n.º 2 (janeiro de 2011): 355–62. http://dx.doi.org/10.1097/igc.0b013e31820731bb.

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Objectives:The aim of this study was to evaluate a long-term follow-up data for oncologic results and surgical morbidity of a laparoscopic nerve-sparing radical hysterectomy (NSRH) in the treatment of FIGO stage IB cervical cancer.Methods:This was a retrospective study that comprised consecutive 125 patients with cervical cancer stage IB1 (n = 105) and IB2 (n = 20) who underwent a laparoscopic NSRH (Piver type III) by a gynecologic oncologist without selecting patients from January 1999 to December 2007.Results:In regression analysis, the operating time (R2linear = 0.311,P< 0.001) and estimated blood loss (R2linear = 0.261,P< 0.001) were decreased, whereas the number of harvested pelvic lymph nodes (R2linear = 0.250,P< 0.001) was increased. Seventeen patients (13.6%, 17/125) were found to have pelvic node metastasis. Para-aortic node metastasis had occurred in 2 patients (5.1%, 2/39). There were high urological complications (13/125, 10.4%) related to radical surgery. Forty-one patients (33%) needed transfusions. Positive surgical margins did not exist. Patients were able to self-void at a mean of 10.3 days postoperatively. The return rates to normal voiding function at postoperative 14 and 21 days were 92.0% and 95.2%, respectively. Thirteen patients (IB1 n = 9, IB2 n = 4) experienced a recurrence postoperatively. Six patients (IB1 n = 3, IB2 n = 3) died of recurrent disease. Five-year disease-free survival rates of cervical cancer IB1 and IB2 were 92% and 78%, respectively (P= 0.1772). Five-year overall survival rates of cervical cancer IB1 and IB2 were 96% and 83%, respectively (P= 0.0437).Conclusions:A laparoscopic NSRH for FIGO stage IB cervical cancer was comparable to open NSRH in terms of early recovery of bladder function. It did not compromise surgical radicality, but revealed high urological complications, long operating time, and much blood loss, compared with conventional radical hysterectomy. However, these surgical morbidities were corrected with increase in experiences.

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Segaert, An, Koen Traen, Philippe Van Trappen, Frederik Peeters, Karin Leunen, Frédéric Goffin e Ignace Vergote. "Robot-Assisted Radical Hysterectomy in Cervical Carcinoma: The Belgian Experience". International Journal of Gynecologic Cancer 25, n.º 9 (novembro de 2015): 1690–96. http://dx.doi.org/10.1097/igc.0000000000000536.

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ObjectiveThe purpose of this study was to report the experience and oncological outcome of robot-assisted radical hysterectomies (RRHs) for cervical cancer performed in Belgium.MethodsPatients undergoing RRH for cervical cancer (n = 109) were prospectively collected between July 2007 and April 2014 in the 5 Belgian centers performing RRH for cervical cancer.ResultsThe median age of the patients was 46 years (range, 31–80 years). Histological types included squamous cell carcinoma in 61 patients, adenocarcinoma in 22 patients, adenosquamous in 8 patients, endometrioid carcinoma in 2 patients, and other types (n = 16). The International Federation of Gynecology and Obstetrics stage distribution was IA (n = 9), stage IB1 (n = 71), stage IB2 (n = 4), stage II (n = 24), and unknown (n = 1). Twenty-four patients received adjuvant therapy, 17 patients underwent radiochemotherapy, and 7 underwent adjuvant radiation. Eighteen patients relapsed, and 5 died of disease. The median follow-up was 27.5 months (range, 3–82 months). The 2- and 5-year overall survivals were 96% and 89%, respectively. The 2- and 5-year disease-free survivals (DFSs) were 88% and 72%, respectively. The 2-year DFS per stage was 100% for IA, 88% for IB1, 100% for IB2, and 83% for II. The 5-year DFS per stage was 100% for stage IA and 75% for IB1. The complications were as expected for radical hysterectomy.ConclusionsThis series confirms the feasibility and safety of RRH not only in cervical cancer stage IA to IB1, but also after neoadjuvant chemotherapy in stage IB2 to IIB.

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Wydra, D., S. Sawicki, S. Wojtylak, T. Bandurski e J. Emerich. "Sentinel node identification in cervical cancer patients undergoing transperitoneal radical hysterectomy: a study of 100 cases". International Journal of Gynecologic Cancer 16, n.º 2 (março de 2006): 649–54. http://dx.doi.org/10.1136/ijgc-00009577-200603000-00030.

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We investigated the feasibility of sentinel lymph node (SN) identification using radioisotopic lymphatic mapping with technetium-99m-labeled nanocolloid and blue-dye injection in 100 patients with early cervical cancer (FIGO stage IB1 in 58, IB2 in 18, and IIA in 24) undergoing radical hysterectomy with pelvic lymphadenectomy. At least one SN was found in 84% on one side and in 66% on both sides. The sentinel detection rates according to the stages were as follows: 96.6% in IB1, 66.7% in IB2, and 62.5% in IIA with at least one SN on one side, and 86.2% in IB1, 38.9% in IB2, and 37.5% in IIA with at least one SN on both sides. Successful identification of at least one SN was less likely in patients with tumors >2 cm (54% of SN) compared with those with tumors ≤2 cm (96% of SN). In 15/22 patients, the SNs were the only lymph nodes that were tumor positive. The false-negative rate for the SN procedure was 3% (3/100). In all false-negative SNs, the primary cervical tumor was above 2 cm and there was an isthmus infiltration. SN detection had 86.4% sensitivity (19/22), 100% specificity (66/66), and 95.5% negative predictive value (63/68). The sentinel node detection rate is relatively high and depends on the tumor size and FIGO stage.

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Mubarak, Fhahri, Wahyu Hendrarti, Hamdayani Lance Abidin e Arfan Abu Bakar. "Identification of Antibiotic-Producing Isolates from the Soil of Pesantren Darul Aman Gombara, Makassar". Indonesian Journal of Pharmaceutical Science and Technology 9, n.º 3 (29 de dezembro de 2022): 181. http://dx.doi.org/10.24198/ijpst.v9i3.32257.

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One source of antibiotics-producing microorganisms that are now widely used as a treatment for infections comes from the soil. Soil is an excellent medium for the growth and development of various microorganisms. The search for new antibiotics is currently urgently needed, because their use is not following the instructions, causing disease resistance. This study aims to get antimicrobial-producing microbial isolates that can inhibit the test microbes and identify the type of isolates. The first stage of microbial isolation was the dilution of the soil sample from 10-1 to 10-5 using the method of pouring on Nutrient Agar (NA) and Potato Dextrose Agar (PDA) medium. It carried further testing of antimicrobial activity against several test microbes out. The results of the isolation got 4 isolates of bacteria and 4 isolates of fungi with different identification of each isolate. In the test microbe, Escherichia coli isolates that gave activity were isolates IB1, IB2, IB3. In the Staphylococcus aureus test bacteria, the isolate that produces activity is the isolate IB1, IB2, IB3, IB4, IJ2, Meanwhile, for the test fungus Candida albicans was inhibited by isolates IB1, IJ1, IJ2, IJ3 and IJ4.

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Schoorlemmer, Jon, e Mitchell Goldfarb. "Fibroblast Growth Factor Homologous Factors and the Islet Brain-2 Scaffold Protein Regulate Activation of a Stress-activated Protein Kinase". Journal of Biological Chemistry 277, n.º 51 (18 de setembro de 2002): 49111–19. http://dx.doi.org/10.1074/jbc.m205520200.

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Fibroblast growth factor homologous factors (FHFs) form native intracellular complexes with the mitogen-activated protein kinase (MAPK) scaffold protein islet-brain 2 (IB2) in adult brain. FHF binding to IB2 facilitates recruitment of the MAPK p38δ (SAPK4), while failing to stimulate binding of JNK, the preferred kinase of the related scaffold IB1 (JIP-1). We now report further biochemical evidence supporting FHFs as regulators of IB2 scaffold activity. Mixed lineage kinase 3 (MLK3) and IB2 synergistically activate p38δ but not the MAPKs JNK-1 and p38α. Binding of p38δ to IB2 is mediated by the carboxyl-terminal half of the scaffold (IB2Δ1–436). FHF2 also binds weakly to IB2Δ1–436and can thereby increase p38δ interaction with IB2Δ1–436. FHF-induced recruitment of p38δ to IB2 is accompanied by increased levels of activated p38δ, and synergistic activation of p38δ by MLK3 and IB2 is further enhanced by FHF2. Consistent with a role for FHFs as signaling molecules, FHF2 isolated from rat brain is serine/threonine-phosphorylated, and FHF can serve as a substrate for p38δin vitro. These results support the existence of a signaling module in which IB2 scaffolds a MLK3/MKK/p38δ kinase cascade. FHFs aid in recruitment of p38 to IB2 and may serve as kinase substrates.

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Sandadi, Samith, Edward J. Tanner, Fady Khoury-Collado, Alessandra Kostolias, Vicky Makker, Dennis S. Chi, Yukio Sonoda, Kaled M. Alektiar, Richard R. Barakat e Nadeem R. Abu-Rustum. "Radical Surgery With Individualized Postoperative Radiation for Stage IB Cervical Cancer: Oncologic Outcomes and Severe Complications". International Journal of Gynecologic Cancer 23, n.º 3 (março de 2013): 553–58. http://dx.doi.org/10.1097/igc.0b013e3182849d53.

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ObjectiveThe objective of this study was to compare morbidity and outcome following radical surgery with or without adjuvant radiation therapy (RT) in the treatment of stages IB1-IB2 cervical carcinoma.MethodsWe retrospectively identified 222 patients with stages IB1-IB2 cervical carcinoma treated initially with radical hysterectomy or radical trachelectomy with or without adjuvant RT from February 2000 to November 2009. All grade 3 or higher complications—those requiring interventional radiology, endoscopic evaluation, or operative intervention—were documented.ResultsOne hundred fifty-eight patients (71%) underwent radical hysterectomy; 64 (29%) underwent radical trachelectomy. One hundred fifty-three patients (69%) underwent surgery alone; 69 (31%) received adjuvant radiation with or without chemosensitization. There was a statistically significant difference in the rate of total grades 1 to 5 late complications between the surgery-alone and surgery + RT groups (12% vs 32%, respectively; P < 0.001); however, the rate of grade 3 or higher complications was similar (5% vs 4%, respectively; P = 0.999). The progression-free and overall survival rates of the entire cohort were both 95%. The 5-year progression-free survival rates for the surgery-alone and surgery + RT groups were 93% and 90% (P = 0.172). The overall survival rates were 96% and 91%, respectively (P = 0.332).ConclusionsThe majority of women with stages IB1-IB2 cervical cancer undergoing radical surgery do not require adjuvant RT, have excellent oncologic outcome, and have low severe complication rates. Nearly one third of our patients required postoperative radiation, with no statistically significant increase in severe complication rate and with similar oncologic outcomes compared with the surgery-only cohort. These data support the continued practice of radical surgery with individualized postoperative radiation for these patients.

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Lea, Jayanthi Sivasothy, Steven Holloway, Wenxin Zheng, Hao Chen e Glorimar Rivera. "Significance of degree of destructive stromal invasion in early stage endocervical adenocarcinoma." Journal of Clinical Oncology 37, n.º 15_suppl (20 de maio de 2019): e17023-e17023. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e17023.

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e17023 Background: Recent evidence has suggested that stratifying endocervical adenocarcinomas based on degree of destructive stromal invasion and desmoplastic response may help further identify risk of lymph node metastasis (1,2). We sought to explore the prognostic influence of the above histopathologic stratification in women undergoing treatment for early stage cervical adenocarcinoma. Methods: Women with stage IA1 – IB2 endocervical adenocarcinoma who underwent radical hysterectomy were included. Demographics and clinico-pathologic data were collected. Three independent gynecologic pathologists performed pathology review for all specimens and tumors were categorized into patterns A, B, and C based on the criteria described by Silva et al (2). Briefly, these criteria include adenocarcinoma without destructive stromal invasion or desmoplastic response (pattern A), minimum destructive invasion (pattern B), and frank invasion (pattern C). Clinico-pathologic data were reviewed and all cases were stratified as either low, intermediate (GOG 92 criteria) or high-risk (positive nodes, parametria, margins). Chi square and Fisher exact test were used for statistical analysis. Results: 46 patients with cervical adenocarcinoma were identified with the following stage distribution: 6 stage IA, 34 stage IB1 and 6 stage IB2. All patients with stage IA disease had pattern A or B tumors. Ten patients with pattern A or B tumors had stage IB1 (N = 9) or IB2 (N = 1). 30 patients had pattern C tumor, all of which were stage IB1-IB2. LVSI was identified in 40% of pattern C versus 6% of pattern B tumors (p < 0.02). All patients who were high-risk for recurrence had pattern C tumors. 16/17 patients who were intermediate-risk had pattern C versus 1/17 with pattern B tumor (p < 0.01). Lymph node metastasis was identified in 11% of pattern C and none in patterns A and B tumors (p < 0.01). All recurrences were diagnosed in patients with pattern C tumors (p < 0.01). Conclusions: Recurrent cervical adenocarcinoma was seen only in patients with pattern C tumors, while no patient with pattern A or B tumors recurred. This histopathologic stratification could be utilized to propose individualized therapy for women with newly diagnosed endocervical adenocarcinoma. References: 1. Diaz De Vivar A al. Int J Gynecol Pathol. 2013;32(6):59;22. Roma AA. Et. al. Gynecol Oncol. 2016; 141: 36.

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Raf'ee, Sayang Syazanna, Mohd Shahir Liew, Noor Amila Zawawi e Kamaluddeen Usman Danyaro. "Thermal Insulation of Residential Construction through the Study of Temperature Difference of Bricks". MATEC Web of Conferences 203 (2018): 06015. http://dx.doi.org/10.1051/matecconf/201820306015.

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This study seeks to measure the temperature difference of 3 types of interlocking bricks and 2 types of conventional bricks, all which are available in Malaysian market. The study aims to assist Malaysia’s residential construction dilemma in masonry. This is done by constructing 5 models using different types of bricks with the same dimensions, finishes and placed in the same area. Six points were taken to measure the temperature differences. The equipment used are 6 Thermocouples and HOBO UX120-014M data logger. Intervals of 15 minutes were recorded with duration of four months in Tronoh, Perak. Results show the best performed brick is IB2, even though IB1 and Clay bricks depict significant temperature differences. Comparing the temperature differences of IB1 and Clay brick, IB1 provide a better performance in a hot weather due to its higher thermal conductivity.

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Tsubamoto, Hiroshi, Riichiro Kanazawa, Kayo Inoue, Yoshihiro Ito, Shinji Komori, Hiroaki Maeda e Shozo Hirota. "Fertility-Sparing Management for Bulky Cervical Cancer Using Neoadjuvant Transuterine Arterial Chemotherapy Followed by Vaginal Trachelectomy". International Journal of Gynecologic Cancer 22, n.º 6 (julho de 2012): 1057–62. http://dx.doi.org/10.1097/igc.0b013e3182596305.

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BackgroundFertility-sparing management for bulky cervical cancer remains under investigation. We investigated the safety of neoadjuvant transuterine arterial chemotherapy (TUAC) followed by a simple vaginal trachelectomy for patients with tumors larger than 3 cm in diameter who desired uterine preservation.MethodsFirst, to assess the safety and efficacy of TUAC, survival and pathological complete response data from 39 patients with a diagnosis of stage IB2 to stage IIB cervical cancer who participated in 2 consecutive trials during 1997–2006 were analyzed. The neoadjuvant chemotherapy regimens were a combination of TUAC using cisplatin with intravenous nedaplatin or irinotecan. Second, to assess the safety of fertility-sparing management with TUAC, medical records of patients matching the following criteria were reviewed during the same period: (1) International Federation of Gynecology and Obstetrics stages IB1 to IIA; (2) maximum diameter of tumor, 3 cm or more; (3) squamous cell carcinoma; (4) no radiological findings of lymph node metastasis; and (5) patient’s strong desire for preservation of the uterus and to undergo TUAC.ResultsThe overall 5-year survival rate of the 39 enrolled patients was 81.0% (95% confidence interval, 64.8%–93.7%). No malignant cells were found in pathologically examined surgical specimens from 14 patients (35.9%), all of whom were alive without recurrence for more than 7 years after treatment. Based on medical records, 7 patients were eligible according to the fertility-sparing criteria, 1 patient with International Federation of Gynecology and Obstetrics stage IB1 cancer, 5 patients with stage IB2, and 1 patient with stage IIA. One patient with stage IB1 cancer and 2 patients with stage IB2 cancer underwent simple vaginal trachelectomy, resection of paracervical tissues, and abdominal lymphadenectomy. Their disease-free intervals were 86, 120, and 65 months, respectively. All 3 patients had regular menses after surgery but no pregnancies, for personal reasons unrelated to fertility.ConclusionsPowerful neoadjuvant chemotherapy regimens resulted in a pathological complete response. Long-term disease-free interval was achieved after fertility-sparing management for bulky cervical cancer in 3 cases.

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Harianja, Shara Yulita, I. Gede Putu Wirawan e Made Sritamin. "ISOLATION AND ABILITY TEST OF PHENOL-DEGRADING BACTERIA FROM THE LIQUID WASTE IN BHAYANGKARA HOSPITAL, DENPASAR CITY, BALI, INDONESIA". International Journal of Biosciences and Biotechnology 9, n.º 1 (30 de setembro de 2021): 49. http://dx.doi.org/10.24843/ijbb.2021.v09.i01.p06.

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Phenol is an organic compound that is toxic to humans and the environment. This compound was contained in the hospital liquid waste and petrochemical-based industrial sectors. This study aims to obtain hydrocarbonoclastic bacterial isolates that act as biodegradation agent in waste handling. Samples obtained from the biofilter tank of liquid waste treatment Bhayangkara Hospital Denpasar,Bali, Indonesia then carried out isolation and inoculation of bacteria in selective media NA (Nutrient Agar) containing Phenol. The bacteria obtained was performed the viability test on the media with various Phenol concentration levels, obtained three isolates of bacteria capable of growing to the concentration Phenol 500 mg / L, i.e. isolates IB2, IB5, and IB10. Therefore, it was performed the degradation ability and rate test on those three isolates. After 72 hours of incubation periods, the change of Phenol concentrations was analyzed using the folinciocalteau method and examined using the spectrophotometer with 660 nm of wavelength. Based on the analysis of final phenol content, the IB2 isolate has the highest degradation capability in the concentration of 600 mg/L (153,4 mg) with a degradation rate of 2,13 mg/h. IB5 isolates have the highest degradation capability in the concentrations of 700 mg/L (109,45 mg) with a degradation rate of 1,52 mg/h. Meanwhile, IB10 isolates show the lowest ability and degradation rate in both concentrations. Through morphological identification and Gram stain, three isolates belong to the Gram-negative rod-shaped bacteria, which has similarities with the Pseudomonas genus.

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Balaya, Vincent, Benedetta Guani, Laurent Magaud, Hélène Bonsang-Kitzis, Charlotte Ngô, Patrice Mathevet e Fabrice Lécuru. "Validation of the 2018 FIGO Classification for Cervical Cancer: Lymphovascular Space Invasion Should Be Considered in IB1 Stage". Cancers 12, n.º 12 (28 de novembro de 2020): 3554. http://dx.doi.org/10.3390/cancers12123554.

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Background: The aim of this study was to assess the prognostic impact of Lymphovascular space invasion (LVSI) in IB1 stage of the revised 2018 International Federation of Gynecology and Obstetrics (FIGO) classification for cervical cancer. Methods: A secondary analysis of two French prospective multicentric trials on Sentinel Lymph node biopsy for cervical cancer was performed. Patients with 2009 FIGO IB1 stage who underwent radical surgery between January 2005 and July 2012 from 28 French expert centers were included. The stage was modified retrospectively according to the new 2018 FIGO staging system. Results: According to the 2009 FIGO classification, 246 patients had IB1 disease stage and fulfilled the inclusion criteria. The median follow-up was 48 months (4–127). Twenty patients (8.1%) experienced a recurrence, and the 5-year Disease Free Survival (DFS) was 90.0%. Compared to 2018 IB1 staged patients, new IB2 had significantly decreased 5-year DFS, 78.6% vs. 92.9%, p = 0.006 whereas IIIC patients had similar 5-year DFS (91.7%, p = 0.95). In the subgroup of patients with FIGO 2018 IB1 stage, the presence of LVSI was associated with a significant decrease in DFS (82.5% vs. 95.8%, p = 0.04). Conclusions: LVSI is associated with decreased 5-year DFS in IB1 2018 FIGO stage and LVSI status should be considered in early-stage cervical cancer for a more precise risk assessment.

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Finan, Michael A., Stephen DeCesare, James V. Fiorica, Richard Chambers, Mitchel S. Hoffman, Richard C. Kline, William S. Roberts e Denis Cavanagh. "Radical Hysterectomy for Stage IB1 versus IB2 Carcinoma of the Cervix". Obstetrical & Gynecological Survey 52, n.º 1 (janeiro de 1997): 29–30. http://dx.doi.org/10.1097/00006254-199701000-00016.

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Reesink-Peters, Nathalie, Jacobus van der Velden, Klaske A. ten Hoor, H. Marike Boezen, Elisabeth G. E. de Vries, Marten S. Schilthuis, Marian J. E. Mourits et al. "Preoperative Serum Squamous Cell Carcinoma Antigen Levels in Clinical Decision Making for Patients With Early-Stage Cervical Cancer". Journal of Clinical Oncology 23, n.º 7 (1 de março de 2005): 1455–62. http://dx.doi.org/10.1200/jco.2005.02.123.

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PurposeTo prevent morbidity associated with double modality treatment, early-stage cervical cancer patients should only be offered surgery when there is a low likelihood for adjuvant radiotherapy. We analyzed whether serum squamous cell carcinoma antigen (SCC-ag) analysis allows better preoperative identification of patients with a low likelihood for adjuvant radiotherapy than currently used clinical parameters.Patients and MethodsIn a cohort study, International Federation of Gynecology and Obstetrics (FIGO) stage, tumor size, and preoperative serum SCC-ag levels, as determined by enzyme immunoassay, were related to the frequency of postoperative indications for adjuvant radiotherapy in 337 surgically treated, FIGO stage IB/IIA, squamous cell cervical cancer patients.ResultsIn patients with normal preoperative SCC-ag, 16% of IB1 and 29% of IB2/IIA had postoperative indications for adjuvant radiotherapy, in contrast to 57% of IB1 and 74% of IB2/IIA patients with elevated (> 1.9 ng/mL) serum SCC-ag (P < .001). Serum SCC-ag was the only independent predictor for a postoperative indication for radiotherapy (odds ratio, 7.1; P < .001). Furthermore, in IB1 patients that did not have indications for adjuvant radiotherapy, 15% of patients with elevated preoperative serum SCC-ag levels recurred within 2 years, compared with 1.6% of patients with normal serum SCC-ag levels (P = .02).ConclusionIn early-stage cervical cancer, determination of serum SCC-ag levels allows more refined preoperative estimation of the likelihood for adjuvant radiotherapy than current clinical parameters, and simultaneously identifies patients at high risk for recurrence when treated with surgery only. The role of preoperative serum SCC-ag in the management of patients with early-stage cervical cancer deserves further investigation.

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Mostafa Gharabaghi, Parvin, Masumeh Bakhshandeh Saraskanrood, Manizheh Sayyahmelli, Mehri Jafari, Elahe Saheb Olad Madarek, Maryam Vaezi, Vahideh Rahmani et al. "Radical Hysterectomy With and Without Neoadjuvant Chemotherapy in Patients With Cervical Cancer Stage IB-IIB". International Journal of Women's Health and Reproduction Sciences 9, n.º 3 (2 de maio de 2021): 200–204. http://dx.doi.org/10.15296/ijwhr.2021.37.

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Objectives: In this study, radical hysterectomy, followed by neoadjuvant chemotherapy (NACT) in patients with locally advanced cervical cancer (LACC) was compared with radical hysterectomy in patients with early-stage cervical cancer. Material and Methods: This retrospective comparative observational study was performed on 13 patients with LACC International Federation of Gynecology and Obstetrics (FIGO) stage IB2-IIB who underwent a radical hysterectomy after NACT between March 2014 and November 2018. This group was compared with 18 patients undergoing radical hysterectomy with cervical cancer FIGO stage IIA-IB1 in the same period of time. Results: In the NACT group, 8 (61.5%) and 5 (38.4%) patients were in stages IIB and IB2, respectively, and 13 (72.2%) cases were in the IB1 stage in the non-NACT group. Post-operative blood transfusion in the NACT group was significantly higher compared to the non-NACT group [5 (38.4%) patients versus 0, P = 0.008]. The estimated blood loss (EBL) and operative time were similar between the groups. Finally, there were no significant differences in terms of intra-operative and other post-operative complications. Conclusions: Radical hysterectomy after NACT in women with LACC seems to be safe and reduces the need for radiation in patients with NACT who are at stage IIB. These results need to be confirmed in studies with a larger patient sample.

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Shimada, M., J. Kigawa, R. Nishimura, M. Hiura, M. Hatae, K. Takehara, A. Sato, H. Kurachi, H. Mizunuma e T. Sugiyama. "Comparison of the outcome between cervical adenocarcinoma and squamous cell carcinoma patients with adjuvant radiotherapy after radical surgery: SGSG/TGCU Intergroup Surveillance". Journal of Clinical Oncology 27, n.º 15_suppl (20 de maio de 2009): 5585. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.5585.

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5585 Background: We conducted the present surveillance to clarify the significance of adjuvant radiotherapy and the cause of poor outcome of adenocarcinoma (AC). Methods: A total of 825 patients with FIGO stage Ib-IIb cervical cancer, who underwent type III radical hysterectomy in 10 institutes of SGSG/ TGCU Intergroup between April 1997 and March 2003, were enrolled in this study. There were 543 patients with squamous cell carcinoma (SCC) (261 in stage Ib1, 67 in Ib2, 83 in IIa, 132 in IIb) and 282 with AC (186 in stage Ib1, 39 in Ib2, 11 in IIa, 46 in IIb). Mean age of patients was 49.0 yrs (range: 19–84 yrs) in SCC and 46.6 yrs (range: 18–84) in AC. Two hundred and fifty-five patient with SCC and 69 with AC received adjuvant radiotherapy including CCRT. Results: The 5-year overall survival rate (OS) for patients with SCC and AC were 87.4% and 83.4%. The OS for stage I patients did not differ between SCC and AC. Stage II patients with AC showed significantly worse prognosis compared with SCC (54.5% vs. 87.4% in IIa, 63.3% vs. 78.8% in IIb). There was a significant difference in OS for patients receiving adjuvant treatment between SCC and AC (83.0% vs. 73.9%). Although the OS for stage I patients did not differ between SCC and AC, the OS for stage II patients with AC was significantly lower (86.9% vs. 50.0% in IIa, 75.5% vs. 61.1% in stage IIb). In patients with stage I, SCC showed significantly higher lymphnode involvement compared with AC (16.5% vs. 9.7% in Ib1, 46.3% vs. 20.1% in Ib2). The incidence of lymphnode involvement did not differ between SCC and AC in patients with stage II (36.4% vs.34.9% in IIa and 39.1% vs.45.5% in IIb). When patients had lymphnode involvement, the outcome of patients with AC showed significantly worse than those with SCC (46.4% vs. 72.3%). The local failure defined as recurrence in stump and pelvis was more frequent in patients with AC compared with SCC (24.6% vs.10.7%). Conclusions: Although the incidence of lymphnode involvement did not differ between AC and SCC, AC patients with lymphnode involvement showed significantly worse outcome. The present study indicates that lower sensitivity to radiotherapy might be an important cause for the poorer prognosis in AC. No significant financial relationships to disclose.

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Nair, Navya, Lu Zhang, Anna Kuan-Celarier, Xiao-cheng Wu e Amelia Jernigan. "Survival differences based on tumor size among stage 1B cervical cancer patients in Louisiana using revised FIGO staging system." Journal of Clinical Oncology 37, n.º 15_suppl (20 de maio de 2019): e17017-e17017. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e17017.

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e17017 Background: In the recently revised 2018 FIGO cervical cancer staging, stage IB is sub-classified into 3 classes based on tumor size. We aim to determine if larger tumor size confers worse survival outcomes in women with stage IB cervical cancer in Louisiana. Methods: Women with stage IB cervical cancer diagnosed between 2010 and 2016 were identified from the Louisiana Tumor Registry. Patients with positive pelvic or para-aortic lymph nodes and those with less than 30 days follow up were excluded. Subjects were classified into three groups based on tumor size: stage IB1 ( < 2cm), stage IB2 (≥ 2cm and < 4cm), and stage IB3 (≥ 4cm). Cox proportional hazards were used to estimate differences in overall (OS) and cause-specific survival (CSS). Covariates included age, race, insurance, census tract-poverty level, and marital status. Results: 198 patients were included with a median follow up time of 43.8 months. Mean age of patients in this cohort was 46.8 years. The subjects were well distributed between the groups: 79 (39.4%) stage IB1, 60 (30.3%) stage IB2, and 60 (30.3%) stage IB3. White women comprised a larger percentage of earlier stage tumors (79.5% 1B1 vs 68.3% 1B2 vs 53.3% 1B3, p < 0.01); Black women were overrepresented in later stage disease (45.0% IB3, 28.3% IB2, 20.5% IB1, p < 0.01). There were no significant differences between the three groups in age, insurance status, poverty level, or marital status. After adjusting for covariates, patients with stage 1B3 disease had worse survival than those with stage 1B1 disease in both OS [HR 6.01 (1.96,18.50)] and CSS [HR 24.31 (2.97,199.00)]. Patients with stage 1B2 disease had worse survival than those with 1B1 disease but this did not reach statistical significance: OS HR 1.88 (0.52,6.74); CSS HR 6.79 (0.77, 59.99). Kaplan-Meier curves of OS and CSS show significant survival differences between the three groups (p < 0.0001) with best outcomes in stage 1B1 and worst in stage 1B3 patients. Conclusions: This analysis of contemporary stage IB cervical cancer patients in Louisiana confirms that tumor size > 4cm confers worse clinical prognosis. Black women are overrepresented advanced stage IB disease. While patients with tumors 2-4cm did worse than those with tumors < 2cm, this did not reach statistical significance. This could be due to the limited sample size of our cohort.

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Luo, Chunqing, Marta Bueno, Jeffrey Kant, Jeremy Martinson e Parmjeet Randhawa. "Genotyping Schemes for Polyomavirus BK, Using Gene-Specific Phylogenetic Trees and Single Nucleotide Polymorphism Analysis". Journal of Virology 83, n.º 5 (24 de dezembro de 2008): 2285–97. http://dx.doi.org/10.1128/jvi.02180-08.

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ABSTRACT BK virus (BKV) genotyping has been historically based on nucleotides 1744 to 1812 in the VP1 gene. We reevaluated this practice by making BKV whole-genome and gene-specific phylogenetic trees as well as performing single nucleotide polymorphism (SNP) analysis of 162 sequences available in the public domain. It was found that currently known BKV subtypes and subgroups can no longer be reliably determined by sequencing certain partial gene sequences. Phylogenetic trees based on large T-antigen (LTA) allow separation of subtype I into subgroups Ia, Ib1, Ib2, and Ic, with bootstrap values of 100%, which are better than bootstraps obtained using VP1 sequences (bootstrap values of 71 to 97%). Subtype IV can be subdivided into subgroups, but LTA bootstrap values (33 to 80%) are lower than those obtained by whole-genome analysis (68 to 87%). Subtypes V and VI provisionally identified earlier on the basis of more limited sequence data are better classified as subgroups Ib2 and Ib1, respectively. LTA positions 3634, 3772, 3934, and 4339 can serve as a minimal SNP set to distinguish between the four major BKV subtypes. No subtype II-, IVa-, or IVb-defining SNPs are available in the VP1 gene. However, the overall congruence of viral strain classification based on either VP1 or LTA phylogenetic analysis indicates that these two areas of the viral genome are genetically linked. Interstrain genetic recombination between distant loci in the VP1 and LTA areas is not a common event.

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Shimada, Muneaki, Hideki Tokunaga, Hiroaki Kobayashi, Mitsuya Ishikawa e Nobuo Yaegashi. "Perioperative treatments for stage IB–IIB uterine cervical cancer". Japanese Journal of Clinical Oncology 50, n.º 2 (23 de dezembro de 2019): 99–103. http://dx.doi.org/10.1093/jjco/hyz200.

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Abstract Japan Society of Gynecologic Oncology guidelines recommended either radical hysterectomy-based approach or the definitive radiotherapy including concurrent chemoradiotherapy as primary treatment for patients with not only stage IB1/IIA1, but also stages IB2, IIA2 and IIB. Based on pathological findings of surgical specimens, patients who underwent radical hysterectomy are divided into three recurrent-risk groups, low-risk, intermediate, and high-risk groups. Although some authors reported the usefulness of adjuvant chemotherapy for intermediate/high-risk patients, radiotherapy was standard adjuvant treatment for pathological-risk patients after radical hysterectomy. It has been uncertain whether neoadjuvant chemotherapy followed by radical hysterectomy is beneficial for stage IB2–IIB patients. Recently, the randomized phase III study revealed that neoadjuvant chemotherapy followed by radical hysterectomy failed to improve survival of stage IB2–IIB patients compared to concurrent chemoradiotherapy. Majority of stage IB2–IIB patients are required adjuvant radiotherapy after radical hysterectomy. The multimodality strategy consisting of radical hysterectomy followed by adjuvant radiotherapy is associated with not only impaired quality of life, but also conflicting of cost-effectiveness. Thereby, some authors investigated the significance of multimodality strategy consisting of chemotherapy before/after radical hysterectomy for stage IB2–IIB cervical cancer. Multimodality strategy consisting of radical hysterectomy/perioperative chemotherapy needs higher curability of radical hysterectomy, higher response to perioperative chemotherapy and less perioperative complications. Consequently, gynecologic oncologists have to examine the patients strictly before treatment and judge whether radical hysterectomy-based approach or definitive irradiation is appropriate for the patient with stage IB–IIB cervical cancer.

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Xing, Junjie, Yulin Jia, James C. Correll, Fleet N. Lee, Richard Cartwright, Mengliang Cao e Longping Yuan. "Analysis of Genetic and Molecular Identity Among Field Isolates of the Rice Blast Fungus with an International Differential System, Rep-PCR, and DNA Sequencing". Plant Disease 97, n.º 4 (abril de 2013): 491–95. http://dx.doi.org/10.1094/pdis-04-12-0344-re.

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The Pi-ta gene deployed in southern U.S. rice germplasm is effective in preventing the infection by strains of Magnaporthe oryzae isolates that carry the avirulence (AVR) gene AVR-Pita1. In the present study, 169 isolates from rice (Oryza sativa) cultivars, with and without Pi-ta, were analyzed for their genetic identity using an international differential system, repetitive element-based polymerase chain reaction (Rep-PCR), and sequence analysis of PCR products of AVR-Pita1. These isolates belong to the races IA1, IB1, IB17, IC1, and IC17 of M. oryzae. These isolates were further classified into 15 distinct groups by Rep-PCR. There was a predominant group within each race. Pathogenicity assays on ‘Katy’ (Pi-ta) and ‘M202’ (pi-ta) rice determined that IC1 was virulent to Katy and M202; IB17, IC17, and most of IA1 and IB1 were avirulent to Katy and virulent to M202, suggesting that the Pi-ta gene in Katy is responsible for preventing infection by these isolates. Consistently, AVR-Pita1 was not amplified from 28 virulent isolates. One AVR-Pita1 allele was amplified by AVR-Pita1-specific primers in 78 avirulent isolates. Interestingly, different AVR-Pita1 alleles were found in each of the 12 avirulent isolates, as determined by DNA sequencing. Sequence analysis of 90 PCR products revealed 10 AVR-Pita1 haplotypes, 4 of which were new. In total, 12 amino acid changes were identified in the new variants when compared with the first described AVR-Pita sequence (AF207841). The finding of isolates with altered AVR-Pita1 from rice cultivars with and without Pi-ta suggests that these virulent isolates were adapted to the field environments in the southern United States. Further research will be needed to verify this prediction.

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Stanca, Mihai, e Mihai Emil Căpîlna. "Prognostic Factors Associated with 5-Year Overall Survival in Cervical Cancer Patients Treated with Radical Hysterectomy Followed by Adjuvant Concurrent Chemoradiation Therapy at a Tertiary Care Center in Eastern Europe". Diagnostics 11, n.º 3 (22 de março de 2021): 570. http://dx.doi.org/10.3390/diagnostics11030570.

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Background: This retrospective observational study aims to assess the 5-year overall survival and the prognostic significance of risk factors of patients who underwent radical hysterectomy followed by adjuvant concurrent chemoradiation therapy (CCRT) for FIGO stage IB1-IIB cervical cancer in a tertiary care center in Eastern Europe. Methods: From January 2010 to February 2019, 222 patients with stage IB1-IIB cervical cancer were treated with radical hysterectomy followed by adjuvant CCRT in our institution. The baseline information consisting of demographic and clinicopathologic data, treatment choices, recurrences, and outcome information was collected and examined. The survival rates were illustrated using Kaplan–Meier curves and prognosis analyses were accomplished using Cox multivariate analyses. Results: The 222 participants had a mean age of 51.2 years (28–76). The median follow-up time was 65.5 months (3–128). Tumor characteristics revealed FIGO stage (IB1 2.3%, IB2 35.1%, IB3 16.7%, IIA1 9%, IIA2 8.6%, IIB 28.4%) and the most encountered histologic cell type was squamous cell carcinoma (80.06%) followed by adenocarcinoma (11.3%). At the time of examination, 157 patients (70.07%) were alive, of which 135 (61%) were alive free of disease and 22 (9%) were alive with disease. The multivariate Cox regression analysis acknowledged stage IIB, parametrial involvement, and the presence of lymph node metastases as independent prognostic risk factors, significantly worsening the oncologic outcomes influencing the survival with a P-value of 0.076, 0.0001, and 0.008, respectively. The 5-year overall survival was 69.9%. Conclusions: Altogether, the study enhances the significance of prognostic risk factors on the 5-year overall survival of patients who underwent radical hysterectomy followed by adjuvant CCRT for FIGO stages IB1-IIB cervical cancer, allowing comparisons with other regions.

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Lu, Hsin-Yu, Wan Hsuan Lee, Chien-Chin Lin, Cheng-Hong Tsai, Feng-Ming Tien, Min Yen Lo, Mei-Hsuan Tseng et al. "Clinico-Genetic and Prognostic Analyses of 635 Patients with Myelodysplastic Neoplasms Based on the 2022 World Health Organization Classification". Blood 142, Supplement 1 (28 de novembro de 2023): 1878. http://dx.doi.org/10.1182/blood-2023-186106.

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Myelodysplastic neoplasms (MDS) are a heterogeneous group of clonal myeloid neoplasms characterized by dysregulated hematopoiesis. In the past several years, major advances in molecular technologies and the development of next generation sequencing have deepened our understanding of MDS pathobiology. Revisions of the existing classification were warranted. Under the aegis of the International Agency for Research on Cancer, the 2022 World Health Organization (WHO) classification was released. The 2022 WHO proposed new categories including MDS with biallelic TP53 inactivation (MDS-bi TP53), MDS, hypoplastic (MDS-h) and MDS with fibrosis (MDS-f). In addition, the novel risk scoring system-Molecular International Prognostic Scoring System (IPSS-M) has been established. There are limited data that explore the application of the 2022 WHO classification of MDS in light of the IPSS-M. In this study, a cohort of 635 patients diagnosed as having primary MDS based on the 2022 WHO criteria was retrospectively reviewed. We aimed to elucidate the differences in genetic features and clinical outcomes among patients with different MDS subtypes, based on the 2022 WHO classification. The survival impact of allogeneic hematopoietic stem cell transplantation (allo-HSCT) was also evaluated. TruSight myeloid sequencing panel and the HiSeq platform were used to analyze the alterations of 54 myeloid neoplasm-relevant genes. Comparison of the genetic profiles of patients with different subtypes of MDS showed that patients with MDS-low blasts (LB) and those with MDS with LB and ring sideroblasts (RS) exhibited comparable mutation profiles, while patients with MDS- SF3B1 had different mutation pattern from that of these two subtypes. Among patients with MDS-increased blasts-1 (IB1), MDS-IB2 and MDS-f, patients with MDS-IB2 had higher frequencies of NRAS (9% vs. 2%, P=0.019) and mono-allelic TP53 (7% vs. 1%, P=0.031) mutations, and a trend of more TET2 (19% vs. 10%, P=0.059) mutations than those with MDS-IB1. In addition, patients with MDS-f exhibited lower incidence of TET2 (0% vs. 19%, P=0.020), and STAG2 mutations (8% vs. 27%, P=0.050) as compared to those with MDS-IB. Furthermore, patients with MDS-bi TP53 had specific concurrent genetic alterations with few co-occurring mutations which differed from those found in patients with MDS-IB or MDS-f. We performed pairwise survival comparisons among each subtypes of MDS (Figure 1). In low-risk MDS, patients with MDS-h had significantly longer median leukemia-free survival (LFS) and overall survival (OS) (185.5 months for median LFS and OS) compared with those with MDS-LB and RS [38.3 months for median LFS ( P=0.013) and OS ( P=0.010)], while had a similar outcome compared to those with MDS-LB [170.2 months for median LFS ( P=0.152) and OS ( P=0.146)], and MDS- SF3B1 [114.6 months for median LFS ( P=0.549) and OS ( P=0.528)]. For patients with increased blasts or bi TP53 mutations, those with bi TP53 inactivation had the worst outcomes (median LFS: 3.9 months and OS: 4.5 months, all P<0.001) compared to those with MDS-f (median LFS: 16.6 months and OS: 17.7 months), MDS-IB2 (median LFS: 10.0 months and OS: 17.7 months), and MDS-IB1 (median LFS: 25.6 months and OS: 31.4 months). Patients with MDS-f had similar survival to those with MDS-IB2 and IB-1 in terms of LFS (16.6 vs. 25.6 months, P=0.271) and OS (17.7 vs. 31.4 months, P=0.194) . Multivariable analysis showed that IPSS-M ( P<0.001), old age (HR for LFS: 1.023; for OS: 1.032, P<0.001), and the 2022 WHO categorization ( P<0.001) could predict LFS and OS independently and that HSCT could improve LFS (HR, 0.492, P=0.001) (Table 1). Subgroup analysis of the impact of transplantation using time-dependent Cox regression revealed that allo-HSCT could prolong both LFS and OS in patients with MDS-IB1 (HR for LFS: 0.293, for OS: 0.350, P<0.001), LFS alone (HR: 0.534, P=0.049) in patients with MDS-IB2, and a trend of LFS (HR: 0.305, P=0.078) in patients with MDS-f. However, allo-HSCT failed to remedy the dismal outcomes for patients with MDS-bi TP53. In conclusion, based on the evidence gathered from this cohort analysis, the 2022 WHO classification promote efficient segregation of this heterogeneous disease, with focus on the differences in molecular features and prognoses across different disease subtypes, leading to accurate MDS diagnosis and effective risk-adapted treatment.

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Fabbroni, Roberto, Sergio Resta e Antonio Sanna. "La paura di ammalarsi: andare incontro a ciò che si voleva evitare". Scienze Biofisiche 1 (novembro de 2020): 1–10. http://dx.doi.org/10.48274/ibi2.

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Questo lavoro si inserisce nel contesto attuale legato al Covid-19 e a come l’influenza mediatica porta e contribuisce alla produzione di molti più casi patologici di quelli che lo stesso virus produrrebbe da solo. È indiscutibile la presenza del virus e come ogni anno accade la conseguente mortalità stagionale che l’accompagna ma in questo elaborato si intende spiegare il contributo nefasto che i media nazionali ed internazionali portano e che tale contributo è sicuramente superiore al danno stesso. A tal proposito ci verranno in aiuto le ricerche psicologiche che analizzano il fenomeno chiamato “la profezia che si auto avvera” e la fisica quantistiche che “vede” nelle conseguenze del Principio d’Indeterminazione di Heisenberg, “l’osservatore che crea la realtà che osserva”. Attraverso ciò che Psicologia e Fisica Quantistica spiegano da oltre 70 anni si può comprendere come la paura generata mediaticamente aiuta le persone ad ammalarsi da ciò che vogliono evitare, fornendo al sistema immunitario elementi depotenzianti che confermano le loro paure.

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Fabbroni, Roberto, Sergio Resta e Davide Pagnoncelli. "Tumore al seno maschile in crescita, quali cause e prevenzione? Il ruolo della Psiche nella manifestazione e proliferazione della malattia tumorale nello specifico caso e in linea generale sulla nascita e proliferazione del tumore." Scienze Biofisiche 3, n.º 1 (outubro de 2021): 1–11. http://dx.doi.org/10.48274/ibi12.

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Scopo di questo articolo è quello di fornire un contributo sulla attenzione e prevenzione del tumore al seno maschile e sul ruolo in generale che possiede la nostra psiche nel favorire questa e altre problematiche similari. Nel contesto specifico possiamo inoltre valutare come le recenti correlazioni tra Neuroscienze, PNEI, Biofisica e Fisica Quantistica possano portare alla conoscenza di Tecniche naturali a supporto della prevenzione ma anche coadiuvanti e quindi integrative delle più usuali terapie in campo oncologico.

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Grigsby, Perry W. "Stage IB1 vs IB2 Carcinoma of the Cervix: Should the New FIGO Staging System Define Therapy?" Gynecologic Oncology 62, n.º 2 (agosto de 1996): 135–36. http://dx.doi.org/10.1006/gyno.1996.0204.

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You, Kai-Yun, Xin-Hui Zhou, Yan-Hui Jiang, Zhuo-Fei Bi, Yi-Min Liu e Xing-Sheng Qiu. "The Selection of Time Interval Between Surgery and Adjuvant Therapy in Early Stage Cervical Cancer". International Journal of Gynecologic Cancer 28, n.º 7 (setembro de 2018): 1325–32. http://dx.doi.org/10.1097/igc.0000000000001307.

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ObjectivesThe optimal interval between surgery and adjuvant treatment has not yet been found in cervical cancer. And whether patients with different FIGO stage should choose different interval is unknown. The purpose of this study was to evaluate whether interval has a different effect on oncologic outcome for patients with different tumor stages.MethodsWe performed a retrospective study of 226 cervical cancer patients who were treated by surgery and adjuvant therapy from May 2005 to August 2015. All patients were divided into 2 groups according to the interval of 5 weeks. Overall survival (OS) and disease-free survival (DFS) were compared between patients with interval shorter and longer than 5 weeks in the whole group and subgroups. Recurrence patterns were also analyzed. Multivariate analysis was performed to explore clinical factors significantly associated with DFS, local recurrence-free survival and distant metastasis-free survival for patients with stage IB2–IIA.ResultsFor patients with stage IA2–IB1, the 5-year OS and DFS were similar between groups of short and long interval with also the comparable results of local and distant failure. For patients with IB2–IIA, both the OS and DFS in the short-interval group were higher than that in the long-interval group. Besides, the rates of local recurrence were found higher in the group of long interval compared with short interval. Multivariable analysis indicated that time interval was an independent predictor of DFS and local recurrence-free survival for patients with stage IB2–IIA.ConclusionsIn cervical cancer patients, time interval between surgery and adjuvant therapy may have different effects on the prognosis in different FIGO stages.

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Căpîlna, Mihai Emil, Belá Szabo, Janos Becsi, Nicolae Ioanid e Bogdan Moldovan. "Radical Trachelectomy Performed During Pregnancy: A Review of the Literature". International Journal of Gynecologic Cancer 26, n.º 4 (maio de 2016): 758–62. http://dx.doi.org/10.1097/igc.0000000000000655.

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ObjectiveCervical cancer is one of the most frequent malignant diseases diagnosed during pregnancy. Abdominal or vaginal radical trachelectomies are fertility-preserving alternatives to radical hysterectomy for young women with early-stage cervical cancer that can be performed during ongoing pregnancy.MethodsA literature review of articles on this subject was conducted through a Medline search for articles published in English or French.ResultsAt this moment, 21 cervical cancer patients, including ours (4 stage IA2, 16 IB1, and 1 IB2) who underwent radical trachelectomy during pregnancy have been reported. Of these, 10 were performed by vaginal route and 11 were abdominal radical trachelectomies.ConclusionsRadical trachelectomy could be offered as an option for pregnant patients with early invasive cervical cancer. It may help women avoid the triple losses of a desired pregnancy, fertility, and motherhood.

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Jitsamruay, Sangtawan, Ronnason Chinram, Kittisak Poolyarat e Thammarat Panityakul. "An Application of Six Sigma for Optimality of Medium Density Fiberboard Production". International Journal of Analysis and Applications 21 (13 de março de 2023): 22. http://dx.doi.org/10.28924/2291-8639-21-2023-22.

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During the production process of MDF, there is a high level of internal bond (IB) variation. This results in the waste of out-of-standard IB values that account for 0.38 % with damage value over 1 million baht/year. The company required products with fewer volatile compounds from formaldehyde adhesives, focusing on reducing the amount of adhesive but still being strong according to IB-specification which will reduce the cost of production by about 20 − 30 million baht/year. The results of wood sampling and IB testing were divided into 6 areas, namely IB1-IB6. It was found that most of the data were symmetrical except for the IB5 data as the area where the most variation occurs. The distributions of the IB1 and IB6 data showed relatively low variability compared to data from other areas. IB1 - IB6 values were normal distribution, expect for IB5. Process capacity in IB2 was relatively high compared to IB from other areas. From the Correlation Matrix and Correlation Map, it was found that the variables that influenced the IB were Press Factor, % Dosing Glue, Heat Circuit1, Primary Circuit Intel and % Mc After Gluing. To conduct the experiment and find the best variable conditions by 25-2 - Factorial Design (Resolution: III). It was found that Glue = 7.4, Heat1 = 234.4, and Press = 6.5 would give IB = 0.88 which was closest to target (0.7). Glue = 7.1, Heat1 = 233.2, and Press = 6.48 would give IB = 1.15 which was the highest value. Results of production conditions at optimum or maximum that can be generalized from Rayleigh Method Dimensional Analysis was found that at the levels of 7.85, 254.28 and 257.70 of Glue, Heat1 and PrimCirIn, the target response (IB) was 0.7. and at the levels of 8.07, 233.35 and 281.60 of Glue, Heat1 and PrimCirIn resulted in a response value (IB) of 1.27.

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Flores, Lucia Edith, Dan Green, Daniela Morales-Espinosa e Lucely Cetina. "Neuroendocrine tumors of uterine cervix in Mexican women." Journal of Clinical Oncology 30, n.º 15_suppl (20 de maio de 2012): e15569-e15569. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e15569.

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e15569 Background: Neuroendocrine tumors of the uterine cervix are rare, aggressive, and carry a poor prognosis. Most are small cell (SCNEC) and large cell (LCNEC). The limited knowledge of this neoplasm is based on small series due to the rarity of the diagnosis.There is a lack of information about NEC in Latin America. We describe both demographic and clinical characteristic of Mexican patients; and their multidisciplinary management in a reference center. Methods: We studied retrospectively clinical and histopathological variables of 33 women treated at the National Cancer Institute of Mexico from 1991 to 2010 with NEC. Patients were allocated into groups according to staging (Group 1 FIGO stages IB1 and IB2; Group 2 IIA-IVA, and Group 3 IVB). Results: Mean age at diagnosis was 50 y.o.; mean tumour size was 4.9 cm. There were 59.4% SCNEC and 40.6% LCNEC. Stage at diagnosis: IB1 15% (n=5), IB2 3% (n=1), IIA 18.2% (n=6), IIB 27.3% (n=9), IIIA 6% (n=2), IVB 27.3% (n=9). Common sites of metastases were lung and liver. The most common presenting symptom was transvaginal bleeding. In Group 1, 6/7 patients received multimodal management with surgery, chemoradiotherapy and induction or adjuvant chemotherapy. In Group 2, 12/17 patients received three modalities, 3/17 received only 2, due to comorbidty. In Group 3, 8/9 received 2 modalities. Patients with one treatment modality were those with disease progression. Cisplatin was used concurrently with radiotherapy; paclitaxel and carboplatin or etoposide and cisplatin were used for either induction or adjuvant settings. Disease free survival in months was: 50.3 (group 1); 23.1 (group 2), and 3.5 (group 3). Overall survival was: 68.5, 46.3, and 17.2 months, respectively. Main sites of recurrence were pelvis, mediastinum, lung, liver, central nervous system, pancreas, adrenal gland, bone and soft tissue. Conclusions: TheNational Cancer Institute of Mexico offers multidisciplinary treatment emphasizing local control after systemic therapy in both early and locally advanced disease; providing the most favourable disease-free survival and overall survival described. To our knowledge, this is the first report of NEC in the Mexican population, where carcinoma of uterine cervix represents yet an important public health issue.

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Lucon, Cleusa Maria Mantovanello, Claudia Mitsue Koike, Alice Ishida Ishikawa, Flávia Rodrigues Alves Patrício e Ricardo Harakava. "Bioprospecção de isolados de Trichoderma spp. para o controle de Rhizoctonia solani na produção de mudas de pepino". Pesquisa Agropecuária Brasileira 44, n.º 3 (março de 2009): 225–32. http://dx.doi.org/10.1590/s0100-204x2009000300002.

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O objetivo deste trabalho foi selecionar e identificar isolados de Trichoderma spp. para o controle do tombamento causado por Rhizoctonia solani (AG-4) em plântulas de pepino (Cucumis sativus L.), além de avaliar o efeito de concentrações crescentes e de combinações dos isolados mais eficientes no controle da doença. Os experimentos foram conduzidos em casa de vegetação, com 490 isolados. O tombamento das mudas foi avaliado uma semana após a aplicação à base das plântulas de substrato infestado com antagonista (1%) e patógeno (1%). Os doze isolados que proporcionaram mais de 85% de redução da doença foram testados em concentrações crescentes para o controle do patógeno (1%): 0,5, 1, 2, 3 e 4%. Também foi avaliado o efeito das combinações dos cinco isolados mais promissores. Os isolados mais efetivos foram identificados pelo sequenciamento da região espaçadores internos transcritos (ITS) do DNA ribossômico. Dos 490 isolados testados 44 (9%) reduziram o tombamento. As concentrações de antagonistas superiores a 2% foram as mais efetivas no controle da doença. Apenas duas combinações resultaram no aumento do controle da doença. Os isolados mais efetivos foram identificados como T. hamatum (IB08, IB30, IB60), T. harzianum (IB34, IB35), T. atroviride (IB13), T. spirale (IB16, IB24) e T. asperellum (IB44). Não foi possível a identificação da espécie de três isolados.

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Fibrianty, Fibrianty, Eko Hanudin e Azwar Ma’as. "Leaching Characteristics of Udipsamment Ameliored by Mineral Soil and Adhesive Polymer". JOURNAL OF TROPICAL SOILS 27, n.º 1 (17 de janeiro de 2022): 17. http://dx.doi.org/10.5400/jts.2022.v27i1.17-25.

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Udipsamment is characterized by sand fraction > 95%, loose, and very high leaching. This study aimed to determine the effect of mineral soil ameliorants and adhesive polymers on the character of nutrient leaching in Udipsamment. The leaching study in lysimeters used a completely randomized design with three replications. The treatments consist of bagasse (B), mineral soil included Inceptisol (I) and Vertisol (V), and adhesive polymers included tapioca 1% and 2% (T1 and T2), tapioca dregs 1% and 2 % (A1 and A2), Polyvinylalcohol 0.1% and 0.2% (P1 and P2). Combination of treatments are IB, VB, IBT1, IBT2, VBT1, VBT2, IBA1, IBA2, VBA1 , VBA2 , IBP1, I BP2, VBP1, and VBP2. Observations were made before and after leaching. The research showed that VBT2 increases moisture-holding capacity. Amelioration improved the ability of Udipsamment to hold nutrients, after leaching for six months, there was a decrease in organic C, total N, and available P compared to before leaching. Amelioration increased the soil CEC, even up to the sixth month leaching, the soil CEC showed a higher value than before leaching. The amount of clay fraction was relatively uniform between the surface and the bottom of the lysimeter, indicating that the adhesive polymer successfully bonding the clay-sand particles and prevented clay leaching.

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Rutledge, Teresa L., Scott A. Kamelle, Todd D. Tillmanns, Natalie S. Gould, Jason D. Wright, David E. Cohn, Thomas J. Herzog et al. "A comparison of stages IB1 and IB2 cervical cancers treated with radical hysterectomy. Is size the real difference?" Gynecologic Oncology 95, n.º 1 (outubro de 2004): 70–76. http://dx.doi.org/10.1016/j.ygyno.2004.07.027.

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Monk, B. J. "A Comparison of Stages IB1 and IB2 Cervical Cancers Treated With Radical Hysterectomy. Is Size the Real Difference?" Yearbook of Obstetrics, Gynecology and Women's Health 2006 (janeiro de 2006): 427–28. http://dx.doi.org/10.1016/s1090-798x(08)70584-8.

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Rutledge, Teresa L., Scott A. Damelle, Todd D. Tillmanns, Natalie S. Gould, Jason D. Wright, David E. Cohn, Thomas J. Herzog et al. "A Comparison of Stages IB1 and IB2 Cervical Cancers Treated With Radical Hysterectomy. Is Size the Real Difference?" Obstetrical & Gynecological Survey 60, n.º 3 (março de 2005): 169–71. http://dx.doi.org/10.1097/01.ogx.0000154424.60839.2b.

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YAMAMOTO, Katsumi, Yoshikazu SHIINOKI, Jun FURUKAWA e Shoshiro NAKAMURA. "A New Group of Antibiotics, Hydroxamic Acid Antimycotic Antibiotics. IV. Structures of Enactins Ia, Ib1, Ib2 and Va." CHEMICAL & PHARMACEUTICAL BULLETIN 39, n.º 6 (1991): 1436–39. http://dx.doi.org/10.1248/cpb.39.1436.

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Chen, I. Ning, I. Te Wang, Hsueh-Yu Mu, J. Timothy Qiu, Wei-Min Liu, Ching-Wen Chang e Yen-Hsieh Chiu. "Comparison of Survival Outcomes between Minimally Invasive Surgery and Open Radical Hysterectomy in Early-Stage Cervical Cancer". Cancers 14, n.º 9 (24 de abril de 2022): 2117. http://dx.doi.org/10.3390/cancers14092117.

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Objectives: To compare the survival outcomes between minimally invasive surgery (MIS) and laparotomy radical hysterectomy in patients with early-stage cervical cancer. Methods: We conducted a retrospective study involving women who received a radical hysterectomy for cervical cancer, stage IA1 with lymphovascular invasion, IA2, IB1, IB2, or IIA from 2008 to 2016. Clinicopathologic and perioperative outcomes were compared using appropriate statistical methodologies. Results: Oncologic survival outcomes were analyzed using the Kaplan–Meier method. Among the 105 cases identified, 58 (55.2%) and 47 (44.8%) women underwent MIS and open radical hysterectomy, respectively. Over a median follow-up period of 62 months, women who underwent MIS and open radical hysterectomy had a 5-year overall survival rate of 87.9% and 89.4% (p = 0.845) and a 5-year disease-free survival rate of 82.5% and 86.7% (p = 0.624), respectively. Conclusions: For early-stage cervical cancer, patients who underwent MIS radical hysterectomy had survival outcomes that were comparable to those who underwent open surgery at our institute.

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Chen, I. Ning, I. Te Wang, Hsueh-Yu Mu, J. Timothy Qiu, Wei-Min Liu, Ching-Wen Chang e Yen-Hsieh Chiu. "Comparison of Survival Outcomes between Minimally Invasive Surgery and Open Radical Hysterectomy in Early-Stage Cervical Cancer". Cancers 14, n.º 9 (24 de abril de 2022): 2117. http://dx.doi.org/10.3390/cancers14092117.

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Objectives: To compare the survival outcomes between minimally invasive surgery (MIS) and laparotomy radical hysterectomy in patients with early-stage cervical cancer. Methods: We conducted a retrospective study involving women who received a radical hysterectomy for cervical cancer, stage IA1 with lymphovascular invasion, IA2, IB1, IB2, or IIA from 2008 to 2016. Clinicopathologic and perioperative outcomes were compared using appropriate statistical methodologies. Results: Oncologic survival outcomes were analyzed using the Kaplan–Meier method. Among the 105 cases identified, 58 (55.2%) and 47 (44.8%) women underwent MIS and open radical hysterectomy, respectively. Over a median follow-up period of 62 months, women who underwent MIS and open radical hysterectomy had a 5-year overall survival rate of 87.9% and 89.4% (p = 0.845) and a 5-year disease-free survival rate of 82.5% and 86.7% (p = 0.624), respectively. Conclusions: For early-stage cervical cancer, patients who underwent MIS radical hysterectomy had survival outcomes that were comparable to those who underwent open surgery at our institute.

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D’Asta, Marco, Ferdinando Antonio Gulino, Francesco Cannone, Carla Ettore, Giulia Bonanno e Giuseppe Ettore. "Early Cervical Cancer and Recurrence after Minimally Invasive Surgery without Uterine Manipulator". Surgeries 3, n.º 4 (29 de setembro de 2022): 277–83. http://dx.doi.org/10.3390/surgeries3040030.

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Objective: Worldwide cervical cancer is the fourth most common cancer and is also the fourth leading cause of death among women, after breast cancer, colorectal cancer, and lung cancer. The aim of this study is to investigate the long-term oncological safety of laparoscopic treatment without the use of a uterine manipulator for patients with early stage cervical cancer. Materials and methods: A single-center retrospective study was conducted at the Department of Obstetrics and Gynecology of ARNAS Garibaldi Nesima on patients surgically treated for early cervical cancer from 2014 to 2017. Inclusion criteria included squamous or adenosquamous histotype, FIGO stage from Ia1 to Ib2, cancer size < 4 cm, ECOG status 0–1, and negative serum beta-HCG. The patients were divided into two groups: treatment with and without an intra-uterine manipulator. Results: Seventy patients were identified, but only thirty-one met the inclusion criteria and were enrolled. All patients underwent surgery: three patients with the uterine manipulator, twenty-eight without. Among the thirty-one patients enrolled, twelve women had cancer in situ (IA1), nineteen had an early stage cervical cancer, in particular two cases of cervical cancer stage IA2, ten cases of cervical cancer stage IB1, and seven cases of cervical cancer stage IB2, according to the FIGO classification. At follow-up, three cases of recurrence occurred, but the uterine manipulator was not used. Conclusion: After five years of follow-up, recurrence rates in patients treated with minimally invasive surgery are about 10%, but the use of a uterine manipulator is not related to a higher level of recurrence rates.

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Tsuji, Keita, Muneaki Shimada, Fumiaki Takahashi, Hideki Tokunaga, Imari Deura, Satoshi Yamaguchi, Toru Nakanishi, Koji Matsuo, Nobuo Yaegashi e Mikio Mikami. "Clinico-pathological characteristics of patients with stage IB1–IB2 (FIGO 2018) uterine cervical cancer: a nationwide study in Japan". International Journal of Clinical Oncology 26, n.º 8 (9 de junho de 2021): 1541–52. http://dx.doi.org/10.1007/s10147-021-01938-4.

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Kusada, Takeaki, Takafumi Toita, Takuro Ariga, Wataru Kudaka, Hitoshi Maemoto, Wataru Makino, Kazuki Ishikawa et al. "Definitive radiotherapy consisting of whole pelvic radiotherapy with no central shielding and CT-based intracavitary brachytherapy for cervical cancer: feasibility, toxicity, and oncologic outcomes in Japanese patients". International Journal of Clinical Oncology 25, n.º 11 (27 de agosto de 2020): 1977–84. http://dx.doi.org/10.1007/s10147-020-01736-4.

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Abstract Background This prospective study investigated the feasibility, toxicity, and oncologic outcomes of definitive radiotherapy (RT) consisting of whole pelvic radiotherapy with no central shielding (noCS-WPRT) and CT-based intracavitary brachytherapy (ICBT) in Japanese patients with cervical cancer. Methods Patients with cervical cancer of FIGO stages IB1–IVA were eligible. The treatment protocol consisted of noCS-WPRT of 45 Gy in 25 fractions and CT-based high dose-rate ICBT of 15 or 20 Gy in 3 or 4 fractions prescribed at point A. The prescribed ICBT dose was decreased if the manual dwell time/position optimization failed to meet organs-at-risk constraints. Graphical optimization and additional interstitial needles were not applied. Results We enrolled 40 patients. FIGO stages were IB1: 11, IB2: 13, IIA2: 1, IIB: 11, IIIB: 3, and IVA: 1. Median (range) pretreatment tumor diameter was 47 (14–81) mm. Point A doses were decreased in 19 of 153 ICBT sessions (12%). The median follow-up duration was 33 months. The 2-year rates of pelvic control, local control (LC), and progression-free survival were 83%, 85%, and 75%, respectively. Pre-ICBT tumor diameter, high-risk clinical target volume (HR-CTV), total HR-CTV D90, and overall treatment time (OTT) significantly affected LC. Late adverse events (grade ≥ 3) were observed in 3 patients (2 in the bladder, 1 in the rectum). Conclusions Definitive RT consisting of noCS-WPRT and CT-based ICBT was feasible for Japanese patients with cervical cancer. To further improve LC, additional interstitial needles for patients with a large HR-CTV and shorter OTT should be considered.

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Zhou, Longen, Jiewen Zhu, Heiko Konig, Xiaoqin Lin, Ravi Bhatia, A. Richard Chamberlin, Phang-Lang Chen e Wen-Hwa Lee. "Small Molecules Targeting Rad51 Recombinase Synergize with Imatinib and Overcome Imatinib-Resistance in CML." Blood 110, n.º 11 (16 de novembro de 2007): 466. http://dx.doi.org/10.1182/blood.v110.11.466.466.

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Abstract Rad51 recombinase is a key downstream effector of BCR-ABL, essential for DNA repair, cell proliferation and survival. In BCR-ABL positive leukemia cells, Rad51, itself a direct substrate of BCR-ABL, is transcriptionally activated through the BCR/ABL-Stat5 pathway. We have identified a novel compound IBR2, which targets Rad51 and inhibits its functions both in vitro and in vivo. We investigated whether targeted inhibition of Rad51 by IBR2 could overcome imatinib-resistance in CML. IBR2 potently inhibited the proliferation of Ba/F3 cells expressing wild-type BCR-ABL (P210), T315I or E255K mutant with the IC50 values (12–20 μM), but had much lesser effect on the Ba/F3 parental cells. By annexin-V staining and FACS analysis, treatment with 20 μM IBR2 for 48 hours significantly killed Ba/F3 cells expressing P210, E255K or T315I with 33.6, 35.8 and 66.5% of apoptotic cells, respectively. The effects of IBR2 on protein expression and phosphorylation of BCR-ABL and Stat5 and Rad51 were examined by Western blotting after 48 hours of exposure to IBR2 (10–20 μM). In Ba/F3 cells expressing BCR-ABL, dose-dependent decreases of Rad51, BCR-ABL, phosphorylated BCR-ABL, and phosphorylated Stat5 were revealed, while c-Abl, p-c-Abl and total Stat5 protein were unchanged. In contrast, there was little effect on Ba/F3 parental cells. In a murine imatinib-resistant chronic myelogenous leukemia (CML) model bearing T315I mutant BCR-ABL, IBR2 at the dose of 100mg/kg daily for 20 days (i.p.) significantly prolonged animal survival. By colony-forming cell (CFC) assays, IBR2 did not significantly inhibit the growth of cord blood progenitor cells (less than 10% up to 40 μM). However, IBR2 at concentrations of 25, 30 and 40 μM could effectively inhibit the growth of CD34+ progenitor cells from CML patients with demonstrated clinical resistance to imatinib and cross-resistance to Nilotinib by 38.9, 54.8 and 95.5%, respectively. In contrast, these cells were inhibited with 5 μM imatinib by 35.2%; with 5 μM nilotinib by less than 9%; and with 0.5 μM dasatinib by up to 41.3%. Synergistic effects were observed upon co-treatment of IBR2 with imatinib in Ba/F3 cells expressing wild-type BCR-ABL. Treatment with 15 μM IBR2 alone resulted in <10% killing of these Ba/F3 cells expressing wild-type BCR-ABL, whereas treatment with 0.1, 0.2, 0.4 and 0.6 μM imatinib induced 6.8, 7.6, 23.1 and 39.3%, apoptosis respectively. IBR2 in combination with imatinib resulted in substantial increases of apoptosis to 28.4, 62.4, 73.6 and 86.4%, respectively. The effects of co-treatment on Rad51, BCR-ABL, and Stat5 protein expression levels were also examined. Treatment with 0.1–0.6 μM imatinib did not influence the Stat5 protein level, while Rad51, BCR-ABL, p-BCR-ABL and p-Stat5 levels were modestly decreased in a dose-dependent manner. In contrast, co-treatment of IBR2 (15 μM) with imatinib, resulted in a remarkable decrease in Rad51, BCR-ABL, p-BCR-ABL and p-Stat5 levels in a dose-dependent manner, but not Stat5 protein level. The significant inhibitory effects elicited by IBR2 or IBR2-imatinib co-treatment support potential clinical applications, which may be especially beneficial for late stage or imatinib-resistant CML patients. Corresponding author: whlee@uci.edu (WHL) and plchen@uci.edu (PLC).

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SALHAN, Sudha, Vrijesh TRIPATHI e Harsha S. GAIKWAD. "Analysis of prognostic factors for 5 year survival in surgically treated patients with carcinoma cervix stages IB1, IB2 and IIA". Asia-Pacific Journal of Clinical Oncology 4, n.º 1 (março de 2008): 42–47. http://dx.doi.org/10.1111/j.1743-7563.2008.00147.x.

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Finan, Michael A., Stephen DeCesare, James V. Fiorica, Richard Chambers, Mitchel S. Hoffman, Richard C. Kline, William S. Roberts e Denis Cavanagh. "Radical Hysterectomy for Stage IB1 vs IB2 Carcinoma of the Cervix: Does the New Staging System Predict Morbidity and Survival?" Gynecologic Oncology 62, n.º 2 (agosto de 1996): 139–47. http://dx.doi.org/10.1006/gyno.1996.0206.

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Slama, Jiri, Daniela Fischerova, Michal Zikan, Roman Kocian, Anna Germanova, Filip Fruhauf, Ladislav Dusek e David Cibula. "Sensitivity of Follow-Up Methods in Patients After Fertility-Sparing Surgery for Cervical Cancers". International Journal of Gynecologic Cancer 27, n.º 1 (1 de janeiro de 2016): 147–53. http://dx.doi.org/10.1097/igc.0000000000000835.

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ObjectiveThe aim of our study was to compare the sensitivity of various methods and their combinations in the follow-up of patients with cervical cancer after fertility-sparing surgery (FSS).MethodsIncluded were women with cervical cancer in stages IA2 to IB2 who underwent FSS, which includes pelvic lymphadenectomy, sentinel lymph node biopsy, abdominal radical trachelectomy, vaginal trachelectomy, or needle conization. Follow-up visits were scheduled at 3-month intervals and included symptom-oriented discussion, gynecological and physical examination, colposcopy, Papanicolaou test, human papillomavirus (HPV) DNA test, and ultrasound examination. All cases with a recurrent disease were thoroughly analyzed, and the results of individual examinations were compared.ResultsIn total, 43 women (IA2, 8; IB1, 33; IB2, 2) were enrolled. The mean patient age was 31 years; most patients were nulliparous (68.4%, 26/38) with squamous cell cancers (26/38). Abdominal radical trachelectomy was performed in 10 women, simple vaginal trachelectomy was performed in 11 women, and conization was performed in 22 women, according to the tumor characteristics and topography. The median duration of the follow-up reached 37 months. Invasive cancer and high- and low-grade squamous intraepithelial lesions were detected in 8, 1, and 1 patients, respectively. All except 1 event were central, detected within the first year after FSS. Only 2 cases were symptomatic. Colposcopy detected 7 of 10 recurrences; 5 of them were HPV positive, and, in 2 cases, a Papanicolaou test revealed abnormalities. Papanicolaou tests were false positive in 27.7%, especially after trachelectomies.ConclusionsMost patients in whom cancer recurred after FSS reveal central or pelvic lesions, which can be successfully treated with salvage surgery or radiotherapy. The early detection of recurrence is an essential condition for a favorable oncological outcome. Colposcopy alone and in combination with HPV positivity showed the highest sensitivity for the detection of recurrent diseases, whereas other methods had limited reliability.

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Suh, Dong Hoon, Hyun Hoon Chung, Jae Weon Kim, Noh Hyun Park, Yong Sang Song e Soon-Beom Kang. "An Occult Invasive Cervical Cancer Found After a Simple Hysterectomy: A 10-Year Experience in a Single Institution". International Journal of Gynecologic Cancer 21, n.º 9 (novembro de 2011): 1646–53. http://dx.doi.org/10.1097/igc.0b013e3182272d0a.

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ObjectiveThe aim of this study was to identify patients who are at risk of a recurrence and those needing adjuvant treatment by risk grouping in invasive cervical cancer after a simple hysterectomy (SH).MethodsDuring 2000–2009, 26 patients who underwent SH and were finally diagnosed with stages higher than IA1 were reviewed retrospectively. The American Joint Committee on Cancer (AJCC) pathologic staging system was adopted. Based on the pathologic findings, the criteria for risk scoring was set: 1 for depth of invasion (DOI) is between 3–5 mm, and 2 for DOI greater than 5 mm; 1 for longest diameter (LD) is between 0.7–20 mm, and 2 for LD greater than 20 mm; 1 for lymphovascular space invasion positive; and 3 each for parametrium, resection margin, and lymph node positive. The final score was calculated by summing up the risk scores. The receiver operation characteristic curve was created to confirm the best cutoff value.ResultsAll patients were stage IA2 to IB2, of which the number of patients in stages IA2, IB1, and IB2 were 1, 24, and 1, respectively. Eleven patients did not receive any further treatment. Of the remaining 15 patients, 11 received radiation therapy, 3 underwent concurrent chemoradiation therapy, and 1 received chemotherapy alone. No patient underwent a radical parametrectomy. During a median follow-up of 67 months (range, 9–122 months), 3 patients (11.5%) showed a recurrence. Patient whose score was 1 to 3, 4 to 5, and 6 or higher was classified into low-risk, intermediate-risk, and high-risk groups, respectively. All patients in the low-risk group did not recur without any adjuvant treatment (sensitivity, 100%; specificity 34.8–65.2%).ConclusionsAdjuvant treatment can be omitted in low-risk group patients with invasive cervical cancer detected after SH.

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Lin, Alexander J., Jason D. Wright, Farrokh Dehdashti, Barry A. Siegel, Stephanie Markovina, Julie Schwarz, Premal H. Thaker, David G. Mutch, Matthew A. Powell e Perry W. Grigsby. "Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with 18F-fluorodeoxyglucose–positron emission tomography in stage IB cervical cancer". International Journal of Gynecologic Cancer 29, n.º 9 (30 de agosto de 2019): 1351–54. http://dx.doi.org/10.1136/ijgc-2019-000528.

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Objective18F-fluorodeoxyglucose–positron emission tomography (FDG-PET) detection of metastatic nodal disease is useful for guiding cervical cancer treatment but the impact of tumor histology is unknown. This study reports the detection of FDG avid pelvic and para-aortic lymph nodes in patients with early stage cervical cancer with squamous carcinoma and adenocarcinoma tumor histology.MethodsPatients with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IB1-2 cervical cancer who underwent pre-surgical FDG-PET between March 1999 and February 2018 were identified in a tertiary academic center database. All patients had radical hysterectomy with pelvic and para-aortic lymph node dissection. Detection of pelvic and para-aortic lymph nodes by FDG-PET versus surgical dissection was compared. FDG-PET sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were determined and stratified by tumor histology.ResultsWe identified 212 patients with early stage cervical cancer (84% FIGO IB1, 16% IB2) who underwent pre-surgical FDG-PET; 137 (65%) patients had squamous carcinoma and 75 (35%) patients had adenocarcinoma. PET/computed tomography was performed in 189 (89%) patients and 23 (11%) had PET only. Surgical dissection revealed positive pelvic and para-aortic lymph nodes in 25% and 3.3% of patients, respectively. For squamous carcinoma, sensitivity, specificity, PPV, and NPV of FDG-PET for pelvic nodal metastasis were 44%, 99%, 95%, and 78%, respectively. For adenocarcinoma, the corresponding results for pelvic nodal metastasis were 25%, 99%, 67%, and 92%, respectively. The overall values for sensitivity, specificity, PPV, and NPV of FDG-PET for para-aortic nodal metastasis were 29%, 99%, 67%, and 98%, respectively.DiscussionPelvic nodal metastasis was less likely to be detected by FDG-PET in patients with early stage adenocarcinoma than with squamous carcinoma.

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Lu, Yong, e Edwin W. Rubel. "Activation of Metabotropic Glutamate Receptors Inhibits High-Voltage-Gated Calcium Channel Currents of Chicken Nucleus Magnocellularis Neurons". Journal of Neurophysiology 93, n.º 3 (março de 2005): 1418–28. http://dx.doi.org/10.1152/jn.00659.2004.

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Using whole cell patch-clamp recordings, we pharmacologically characterized the voltage-gated Ca2+ channel (VGCC) currents of chicken nucleus magnocellularis (NM) neurons using barium as the charge carrier. NM neurons possessed both low- and high-voltage-activated Ca2+ channel currents (HVA IBa2+). The N-type channel blocker (ω-conotoxin-GVIA) inhibited more than half of the total HVA IBa2+, whereas blockers of L- and P/Q-type channels each inhibited a small fraction of the current. Metabotropic glutamate receptor (mGluR)-mediated modulation of the HVA IBa2+ was examined by bath application of glutamate (100 μM), which inhibited the HVA IBa2+ by an average of 16%. The inhibitory effect was dose dependent and was partially blocked by ω-conotoxin-GVIA, indicating that mGluRs modulate N and other type HVA IBa2+. The nonspecific mGluR agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarbosylic acid (1S,3R-ACPD), mimicked the inhibitory effect of glutamate on HVA IBa2+. Group I–III mGluR agonists showed inhibition of the HVA current with the most potent being the group III agonist l(+)-2-amino-4-phosphonobutyric acid. 1S,3R-ACPD (200 μM) had no effect on K+ or Na+ currents. The firing properties of NM neurons were also not altered by 1S,3R-ACPD. We propose that the inhibition of VGCC currents by mGluRs limits depolarization-induced Ca2+ entry into these highly active NM neurons and regulates their Ca2+ homeostasis.

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Chen, Xiaolin, Hui Duan, Ping Liu, Lihong Lin, Yan Ni, Donglin Li, Encheng Dai et al. "Development and validation of a prognostic nomogram for 2018 FIGO stages IB1, IB2, and IIA1 cervical cancer: a large multicenter study". Annals of Translational Medicine 10, n.º 2 (janeiro de 2022): 121. http://dx.doi.org/10.21037/atm-21-6367.

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