Bibliografias temáticas / IB12

Literatura científica selecionada sobre o tema "IB12"

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Publicado: 26 de julho de 2024
Última modificação: 27 de julho de 2024

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Artigos de revistas sobre o assunto "IB12"

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Panigrahy, Rabi Narayan, Susanta Kumar Panda e Prabhakar Reddy Veerareddy. "FORMULATION AND IN VITRO EVALUATION OF COMBINED FLOATING-BIOADHESIVE TABLETS OF IMATINIB MESYLATE". International Journal of Pharmacy and Pharmaceutical Sciences 9, n.º 10 (1 de novembro de 2017): 27. http://dx.doi.org/10.22159/ijpps.2017v9i11.18894.

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Objective: Gastro retentive drug delivery system (GRDDS) pertaining to its attributes like gastric retention time and the extended drug release profile has significantly improved patient compliance. The objective of the present study is to formulate and evaluate a stomach-specific floating-bioadhesive tablet of imatinib mesylate for prolonged residence in the stomach in the treatment of gastrointestinal stromal tumors (GIST).Methods: All the tablets were prepared with hydroxypropylmethylcellulose (HPMC), guar gum, sodium alginate, and carbopol using direct compression technique. Physical characterization, in vitro dissolution, the mucoadhesive force along with data analysis was done on each tablet. Results: The pre-compression characteristics of powder mixtures found to be satisfactory for all formulation batches. The results of physical evaluation for all batches were complying with pharmacopeia specification. The swelling index for all formulation batches was approximately 100% after 8 hours. The bioadhesive force (mean ± SD) reported in a range of 0.05 ± 0.09 to 0.18 ± 0.06 N/m2. It was observed that the release rate of tablets was decreased when the viscosity and concentration of the polymer were increased. Formulation batches IB1, IB2, IB4, IB5, IB6, IB9, IB10, IB11, and IB13 follows Higuchi Matrix model kinetics; whereas IB3, IB7, IB8, and IB12 follows Korsmeyer- Peppas model kinetics.Conclusion: Formulation batch IB9 reported a considerable swelling index, floating behavior, more bioadhesive strength with uniform drug release pattern. Therefore formulation batch IB9 was selected as optimized batch and were kept for further evaluation studies.
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Litaiff, Eleilza de Castro, Wanderli Pedro Tadei, Jorge Ivan Rebelo Porto e Ila Maria de Aguiar Oliveira. "Analysis of toxicity on Bacillus sphaericus from amazonian soils to Anopheles darlingi and Culex quinquefasciatus larvae". Acta Amazonica 38, n.º 2 (2008): 255–62. http://dx.doi.org/10.1590/s0044-59672008000200008.

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Bioassays under laboratory conditions aiming to determine the larvicidal activity of Bacillus sphaericus were carried out on Anopheles darlingi and Culex quinquefasciatus. In order to estimate the toxicity through median lethal concentration (LC50) and the relative potency of the strains to B. sphaericus standard strain 2362, probit analysis was performed utilizing the POLO-PC program. The findings of LC50 pointed out high effectiveness on strains IB15 (0.040 ppm), IB19 and S1116 (0.048 ppm), IB16 (0.052 ppm) and S265 (0.057 ppm). Strain IB15 presented nearly 50% more potency than strain 2362 in bioassays conducted on A. darlingi. It was observed that IB16 and S1116 strains were the most powerful against C. quinquefasciatus, showing to be about 300-400% stronger than 2362 strain. The results show that laboratory conditioned evaluation can be an important way to select promising bacteria with entomopathogenic action on biolarvicides production for use on mosquitoes breeding sites.
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Grisaru, Dan A., Allan Covens, Edmee Franssen, William Chapman, Patricia Shaw, Terence Colgan, Joan Murphy et al. "Histopathologic score predicts recurrence free survival after radical surgery in patients with stage IA2–IB12 cervical carcinoma". Cancer 97, n.º 8 (15 de abril de 2003): 1904–8. http://dx.doi.org/10.1002/cncr.11269.

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Park, Nae Yoon, Gun Oh Chong, Dae Gy Hong, Young Lae Cho, Il Soo Park e Yoon Soon Lee. "Oncologic Results and Surgical Morbidity of Laparoscopic Nerve-Sparing Radical Hysterectomy in the Treatment of FIGO Stage IB Cervical Cancer: Long-Term Follow-Up". International Journal of Gynecologic Cancer 21, n.º 2 (janeiro de 2011): 355–62. http://dx.doi.org/10.1097/igc.0b013e31820731bb.

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Objectives:The aim of this study was to evaluate a long-term follow-up data for oncologic results and surgical morbidity of a laparoscopic nerve-sparing radical hysterectomy (NSRH) in the treatment of FIGO stage IB cervical cancer.Methods:This was a retrospective study that comprised consecutive 125 patients with cervical cancer stage IB1 (n = 105) and IB2 (n = 20) who underwent a laparoscopic NSRH (Piver type III) by a gynecologic oncologist without selecting patients from January 1999 to December 2007.Results:In regression analysis, the operating time (R2linear = 0.311,P< 0.001) and estimated blood loss (R2linear = 0.261,P< 0.001) were decreased, whereas the number of harvested pelvic lymph nodes (R2linear = 0.250,P< 0.001) was increased. Seventeen patients (13.6%, 17/125) were found to have pelvic node metastasis. Para-aortic node metastasis had occurred in 2 patients (5.1%, 2/39). There were high urological complications (13/125, 10.4%) related to radical surgery. Forty-one patients (33%) needed transfusions. Positive surgical margins did not exist. Patients were able to self-void at a mean of 10.3 days postoperatively. The return rates to normal voiding function at postoperative 14 and 21 days were 92.0% and 95.2%, respectively. Thirteen patients (IB1 n = 9, IB2 n = 4) experienced a recurrence postoperatively. Six patients (IB1 n = 3, IB2 n = 3) died of recurrent disease. Five-year disease-free survival rates of cervical cancer IB1 and IB2 were 92% and 78%, respectively (P= 0.1772). Five-year overall survival rates of cervical cancer IB1 and IB2 were 96% and 83%, respectively (P= 0.0437).Conclusions:A laparoscopic NSRH for FIGO stage IB cervical cancer was comparable to open NSRH in terms of early recovery of bladder function. It did not compromise surgical radicality, but revealed high urological complications, long operating time, and much blood loss, compared with conventional radical hysterectomy. However, these surgical morbidities were corrected with increase in experiences.
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Segaert, An, Koen Traen, Philippe Van Trappen, Frederik Peeters, Karin Leunen, Frédéric Goffin e Ignace Vergote. "Robot-Assisted Radical Hysterectomy in Cervical Carcinoma: The Belgian Experience". International Journal of Gynecologic Cancer 25, n.º 9 (novembro de 2015): 1690–96. http://dx.doi.org/10.1097/igc.0000000000000536.

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ObjectiveThe purpose of this study was to report the experience and oncological outcome of robot-assisted radical hysterectomies (RRHs) for cervical cancer performed in Belgium.MethodsPatients undergoing RRH for cervical cancer (n = 109) were prospectively collected between July 2007 and April 2014 in the 5 Belgian centers performing RRH for cervical cancer.ResultsThe median age of the patients was 46 years (range, 31–80 years). Histological types included squamous cell carcinoma in 61 patients, adenocarcinoma in 22 patients, adenosquamous in 8 patients, endometrioid carcinoma in 2 patients, and other types (n = 16). The International Federation of Gynecology and Obstetrics stage distribution was IA (n = 9), stage IB1 (n = 71), stage IB2 (n = 4), stage II (n = 24), and unknown (n = 1). Twenty-four patients received adjuvant therapy, 17 patients underwent radiochemotherapy, and 7 underwent adjuvant radiation. Eighteen patients relapsed, and 5 died of disease. The median follow-up was 27.5 months (range, 3–82 months). The 2- and 5-year overall survivals were 96% and 89%, respectively. The 2- and 5-year disease-free survivals (DFSs) were 88% and 72%, respectively. The 2-year DFS per stage was 100% for IA, 88% for IB1, 100% for IB2, and 83% for II. The 5-year DFS per stage was 100% for stage IA and 75% for IB1. The complications were as expected for radical hysterectomy.ConclusionsThis series confirms the feasibility and safety of RRH not only in cervical cancer stage IA to IB1, but also after neoadjuvant chemotherapy in stage IB2 to IIB.
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Wydra, D., S. Sawicki, S. Wojtylak, T. Bandurski e J. Emerich. "Sentinel node identification in cervical cancer patients undergoing transperitoneal radical hysterectomy: a study of 100 cases". International Journal of Gynecologic Cancer 16, n.º 2 (março de 2006): 649–54. http://dx.doi.org/10.1136/ijgc-00009577-200603000-00030.

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We investigated the feasibility of sentinel lymph node (SN) identification using radioisotopic lymphatic mapping with technetium-99m-labeled nanocolloid and blue-dye injection in 100 patients with early cervical cancer (FIGO stage IB1 in 58, IB2 in 18, and IIA in 24) undergoing radical hysterectomy with pelvic lymphadenectomy. At least one SN was found in 84% on one side and in 66% on both sides. The sentinel detection rates according to the stages were as follows: 96.6% in IB1, 66.7% in IB2, and 62.5% in IIA with at least one SN on one side, and 86.2% in IB1, 38.9% in IB2, and 37.5% in IIA with at least one SN on both sides. Successful identification of at least one SN was less likely in patients with tumors >2 cm (54% of SN) compared with those with tumors ≤2 cm (96% of SN). In 15/22 patients, the SNs were the only lymph nodes that were tumor positive. The false-negative rate for the SN procedure was 3% (3/100). In all false-negative SNs, the primary cervical tumor was above 2 cm and there was an isthmus infiltration. SN detection had 86.4% sensitivity (19/22), 100% specificity (66/66), and 95.5% negative predictive value (63/68). The sentinel node detection rate is relatively high and depends on the tumor size and FIGO stage.
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Mubarak, Fhahri, Wahyu Hendrarti, Hamdayani Lance Abidin e Arfan Abu Bakar. "Identification of Antibiotic-Producing Isolates from the Soil of Pesantren Darul Aman Gombara, Makassar". Indonesian Journal of Pharmaceutical Science and Technology 9, n.º 3 (29 de dezembro de 2022): 181. http://dx.doi.org/10.24198/ijpst.v9i3.32257.

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One source of antibiotics-producing microorganisms that are now widely used as a treatment for infections comes from the soil. Soil is an excellent medium for the growth and development of various microorganisms. The search for new antibiotics is currently urgently needed, because their use is not following the instructions, causing disease resistance. This study aims to get antimicrobial-producing microbial isolates that can inhibit the test microbes and identify the type of isolates. The first stage of microbial isolation was the dilution of the soil sample from 10-1 to 10-5 using the method of pouring on Nutrient Agar (NA) and Potato Dextrose Agar (PDA) medium. It carried further testing of antimicrobial activity against several test microbes out. The results of the isolation got 4 isolates of bacteria and 4 isolates of fungi with different identification of each isolate. In the test microbe, Escherichia coli isolates that gave activity were isolates IB1, IB2, IB3. In the Staphylococcus aureus test bacteria, the isolate that produces activity is the isolate IB1, IB2, IB3, IB4, IJ2, Meanwhile, for the test fungus Candida albicans was inhibited by isolates IB1, IJ1, IJ2, IJ3 and IJ4.
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Schoorlemmer, Jon, e Mitchell Goldfarb. "Fibroblast Growth Factor Homologous Factors and the Islet Brain-2 Scaffold Protein Regulate Activation of a Stress-activated Protein Kinase". Journal of Biological Chemistry 277, n.º 51 (18 de setembro de 2002): 49111–19. http://dx.doi.org/10.1074/jbc.m205520200.

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Fibroblast growth factor homologous factors (FHFs) form native intracellular complexes with the mitogen-activated protein kinase (MAPK) scaffold protein islet-brain 2 (IB2) in adult brain. FHF binding to IB2 facilitates recruitment of the MAPK p38δ (SAPK4), while failing to stimulate binding of JNK, the preferred kinase of the related scaffold IB1 (JIP-1). We now report further biochemical evidence supporting FHFs as regulators of IB2 scaffold activity. Mixed lineage kinase 3 (MLK3) and IB2 synergistically activate p38δ but not the MAPKs JNK-1 and p38α. Binding of p38δ to IB2 is mediated by the carboxyl-terminal half of the scaffold (IB2Δ1–436). FHF2 also binds weakly to IB2Δ1–436and can thereby increase p38δ interaction with IB2Δ1–436. FHF-induced recruitment of p38δ to IB2 is accompanied by increased levels of activated p38δ, and synergistic activation of p38δ by MLK3 and IB2 is further enhanced by FHF2. Consistent with a role for FHFs as signaling molecules, FHF2 isolated from rat brain is serine/threonine-phosphorylated, and FHF can serve as a substrate for p38δin vitro. These results support the existence of a signaling module in which IB2 scaffolds a MLK3/MKK/p38δ kinase cascade. FHFs aid in recruitment of p38 to IB2 and may serve as kinase substrates.
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Sandadi, Samith, Edward J. Tanner, Fady Khoury-Collado, Alessandra Kostolias, Vicky Makker, Dennis S. Chi, Yukio Sonoda, Kaled M. Alektiar, Richard R. Barakat e Nadeem R. Abu-Rustum. "Radical Surgery With Individualized Postoperative Radiation for Stage IB Cervical Cancer: Oncologic Outcomes and Severe Complications". International Journal of Gynecologic Cancer 23, n.º 3 (março de 2013): 553–58. http://dx.doi.org/10.1097/igc.0b013e3182849d53.

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ObjectiveThe objective of this study was to compare morbidity and outcome following radical surgery with or without adjuvant radiation therapy (RT) in the treatment of stages IB1-IB2 cervical carcinoma.MethodsWe retrospectively identified 222 patients with stages IB1-IB2 cervical carcinoma treated initially with radical hysterectomy or radical trachelectomy with or without adjuvant RT from February 2000 to November 2009. All grade 3 or higher complications—those requiring interventional radiology, endoscopic evaluation, or operative intervention—were documented.ResultsOne hundred fifty-eight patients (71%) underwent radical hysterectomy; 64 (29%) underwent radical trachelectomy. One hundred fifty-three patients (69%) underwent surgery alone; 69 (31%) received adjuvant radiation with or without chemosensitization. There was a statistically significant difference in the rate of total grades 1 to 5 late complications between the surgery-alone and surgery + RT groups (12% vs 32%, respectively; P < 0.001); however, the rate of grade 3 or higher complications was similar (5% vs 4%, respectively; P = 0.999). The progression-free and overall survival rates of the entire cohort were both 95%. The 5-year progression-free survival rates for the surgery-alone and surgery + RT groups were 93% and 90% (P = 0.172). The overall survival rates were 96% and 91%, respectively (P = 0.332).ConclusionsThe majority of women with stages IB1-IB2 cervical cancer undergoing radical surgery do not require adjuvant RT, have excellent oncologic outcome, and have low severe complication rates. Nearly one third of our patients required postoperative radiation, with no statistically significant increase in severe complication rate and with similar oncologic outcomes compared with the surgery-only cohort. These data support the continued practice of radical surgery with individualized postoperative radiation for these patients.
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Lea, Jayanthi Sivasothy, Steven Holloway, Wenxin Zheng, Hao Chen e Glorimar Rivera. "Significance of degree of destructive stromal invasion in early stage endocervical adenocarcinoma." Journal of Clinical Oncology 37, n.º 15_suppl (20 de maio de 2019): e17023-e17023. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e17023.

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e17023 Background: Recent evidence has suggested that stratifying endocervical adenocarcinomas based on degree of destructive stromal invasion and desmoplastic response may help further identify risk of lymph node metastasis (1,2). We sought to explore the prognostic influence of the above histopathologic stratification in women undergoing treatment for early stage cervical adenocarcinoma. Methods: Women with stage IA1 – IB2 endocervical adenocarcinoma who underwent radical hysterectomy were included. Demographics and clinico-pathologic data were collected. Three independent gynecologic pathologists performed pathology review for all specimens and tumors were categorized into patterns A, B, and C based on the criteria described by Silva et al (2). Briefly, these criteria include adenocarcinoma without destructive stromal invasion or desmoplastic response (pattern A), minimum destructive invasion (pattern B), and frank invasion (pattern C). Clinico-pathologic data were reviewed and all cases were stratified as either low, intermediate (GOG 92 criteria) or high-risk (positive nodes, parametria, margins). Chi square and Fisher exact test were used for statistical analysis. Results: 46 patients with cervical adenocarcinoma were identified with the following stage distribution: 6 stage IA, 34 stage IB1 and 6 stage IB2. All patients with stage IA disease had pattern A or B tumors. Ten patients with pattern A or B tumors had stage IB1 (N = 9) or IB2 (N = 1). 30 patients had pattern C tumor, all of which were stage IB1-IB2. LVSI was identified in 40% of pattern C versus 6% of pattern B tumors (p < 0.02). All patients who were high-risk for recurrence had pattern C tumors. 16/17 patients who were intermediate-risk had pattern C versus 1/17 with pattern B tumor (p < 0.01). Lymph node metastasis was identified in 11% of pattern C and none in patterns A and B tumors (p < 0.01). All recurrences were diagnosed in patients with pattern C tumors (p < 0.01). Conclusions: Recurrent cervical adenocarcinoma was seen only in patients with pattern C tumors, while no patient with pattern A or B tumors recurred. This histopathologic stratification could be utilized to propose individualized therapy for women with newly diagnosed endocervical adenocarcinoma. References: 1. Diaz De Vivar A al. Int J Gynecol Pathol. 2013;32(6):59;22. Roma AA. Et. al. Gynecol Oncol. 2016; 141: 36.
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Teses / dissertações sobre o assunto "IB12"

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Jennings, Jason Samuel Robert. "Candidate inflammatory bowel disease gene analysis at the IBD2 locus". Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445947.

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Moore, Joel M. "Investigating the DNA binding properties of the initiator binding protein 2 (IBP2) in maize (Zea mays)". Tallahassee, Florida : Florida State University, 2009. http://etd.lib.fsu.edu/theses/available/etd-11092009-115855/.

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Thesis (M.A.)--Florida State University, 2009.
Advisor: Hank W. Bass, Florida State University, College of Arts and Sciences, Dept. of Biological Science. Title and description from dissertation home page (viewed on May 3, 2010). Document formatted into pages; contains vi, 23 pages. Includes bibliographical references.
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Moes, Michèle. "Interaction of the cytoskeletal protein talin with the integrin beta3 subunit cytoplasmic tail: characterization of the talin rod IBS2 integrin binding site". Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210658.

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Talin is a multifunctional cytoskeletal protein that plays a critical role in linking the actin cytoskeleton to the integrin family of transmembrane cell adhesion receptors. Two distinct integrin binding sites have been identified in talin, one present in the globular head domain (IBS1) and involved in integrin activation, and a second (IBS2), that has been delineated to a 130 residue fragment of the talin rod domain, but whose functional role is still elusive (Tremuth et al.2004). The objective of the present study was to define the minimal structure of talin IBS2 and to investigate its functional role in the integrin-cytoskeleton connection.

In the first part of this study, we used a combination of three different experimental approaches to define the minimal structure of talin IBS2: 1) an in silico bioinformatics approach to analyse sequence conservation of talin IBS2, 2) an in vivo cell biology approach to study the subcellular localization of recombinant talin fragments covering IBS2 in CHOáIIbâ3 cells, and 3) an in vitro biochemical approach consisting in protein overlay, pull down and Surface Plasmon Resonance (SPR) assays, to study the direct interaction between talin IBS2 and the integrin â3 subunit. We delineated IBS2 to a single amphipathic á-helical repeat of 23 residues within the talin rod domain. We further provided evidence that a two amino acid mutation(L2094I2095/AA) was sufficient to inactivate the IBS2 site, due to a disruption of the á helix structure, as demonstrated by infrared spectroscopy. In addition, we identified 2 lysine residues (K2085, K2089) exposed on the solvent face of á helix 50, which are directly involved in the talin IBS2-integrin interaction.

In the second part of this study, we investigated the functional role of talin IBS2 in spreading defective talin (-/-) cells and showed that in contrast to full-length wild type talin, an IBS2 LI/AA mutant talin was unable to fully rescue the spread phenotype of these cells. These results provide the first direct evidence that IBS2 in the talin rod is essential to link integrins to the actin cytoskeleton.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished

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Alleyne-Mike, Kellie. "A retrospective study of patients with Stage IB2 cervical cancer treated at Groote Schuur Hospital 1993-2008". Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/2854.

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Großmann, Mona [Verfasser], S. [Akademischer Betreuer] Zierz, G. [Akademischer Betreuer] Stoltenburg-Didinger e R. [Akademischer Betreuer] Horstkorte. "Die C57BL/6 GNE+/-Maus als Modell für die hereditäre Einschlusskörpermyopathie Typ 2 (h-IBM2) / Mona Großmann. Betreuer: S. Zierz ; G. Stoltenburg-Didinger ; R. Horstkorte". Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2016. http://d-nb.info/1089085214/34.

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Tucher, von Simmelsdorf Elisabeth Maria [Verfasser]. "Therapieoptionen bei der Behandlung des invasiven Zervixkarzinoms FIGO IA1 L1- IB1 bei Patientinnen im fertilen Alter / Elisabeth Freifrau Tucher von Simmelsdorf". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1029848718/34.

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Nascimento-Fonseca, Sandra Marques. "Outcomes of patients with stage IB1 and IB2 Cervical Cancer who have had Wertheim's Hysterectomies with or without adjuvant chemo-radiotherapy as primary treatment at Charlotte Maxeke Johannesburg Academic Hospital". Thesis, 2018. https://hdl.handle.net/10539/25267.

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A research report submitted to the University of the Witwatersrand in partial fulfilment for the degree of Master of Medicine 2016.
Background Cervical cancer is the 3rd most common female malignancy worldwide. It is classified and managed according to stage as defined by the FIGO Committee on Gynaecology Oncology classification of 2009. Stage specific treatment is tailored according to prognosis and risk of recurrence as determined by tumour type, tumour size, tumour grade, lymph node metastases, lymphovascular space involvement (LVSI), parametrial spread and presence of any other metastatic deposits at presentation. This study only concentrated on patients who presented with Stage IB1 and 1B2 tumours managed by Class III / Meig’s Radical / Wertheim’s hysterectomy and bilateral pelvic lymphadenectomy. Aims Primary Outcome 1. Assess disease free interval and overall survival 2 years post-operatively. Secondary Outcomes 1. Assess adequacy of patient selection 2. Assess risk factors for recurrence 3. Compare recurrence risk of HIV positive patients versus HIV negative patients. 4. Determine surgical and post-surgical complication rate. Materials and Methods This was a retrospective institutional cohort study conducted at the Charlotte Maxeke Johannesburg Academic Hospital. All patients with Stage IB1 or IB2 cervical cancer treated with Wertheim hysterectomies between 2002 and 2012 were included. Surgical records, histology records, further postoperative management records and gynaecological outpatient follow up records were used to collect data for the patients. Histological findings post-operatively determined further management. Surgical margins had to be 10mm clear of tumour with no positive lymph nodes otherwise external beam radiotherapy and brachytherapy or chemo-radiotherapy were recommended in addition to primary surgical management. Results Of the 72 patients initially identified, 69 patients were suitable for study inclusion. The mean age of the study population was 45 years. Study population racial distribution: 68.12% were Black, 26.09% were White, 2.9% were Coloured and 2.9% were Indian. Average parity and gravidity of patients alive at the end of the study was 2.86 and 3.56; while average parity and gravidity of patients deceased at the end of the study was 2.5 and 2.8 respectively. Study population ECOG status: 16% were ECOG 0, 83% were ECOG 1 and 1% were ECOG 2. Overall survival at the end of the study was 86% and patients were disease free postoperatively for an average of 5 years. Thirty three percent of the patients were disease free for more than 5 years. Preoperative clinical staging and postoperative histological staging correlated only in 61% of cases. Correct management by Wertheim’s hysterectomy was rendered to 75% of patients whereas the remainder were incorrectly managed and should have had either a simple hysterectomy with no pelvic lymphadenectomy or radiotherapy only as primary therapy. More advanced stages, tumours ≥ 4cm, adenomatous cell type, > 5mm depth of invasion, >7mm lateral spread, higher number of nodes positive for metastatic disease, surgical margins  10mm, positive lympohovascular space, parametrial and pouch of Douglas (POD) involvement were factors that had a poorer prognosis with regards overall survival, disease-free interval or both. Poorly differentiated tumours were more likely to recur but did not have a poorer prognosis compared with regards to overall survival or disease free interval at 2 or more years compared to well and moderately differentiated tumours. Mortality of HIV reactive patients was 16.7% compared to 12.5% for HIV non-reactive patients. This difference was not statistically significant at the 95% confidence level. HIV status also did not increase risk of recurrence. Lower CD4 counts were shown to have a lower disease-free period and overall survival. Intra-operative surgical complication rate was 6%. Immediate post-operative complication rate was 16%. Of the patients who required DXT or DXT and chemotherapy 33% had side-effects or complications from adjuvant therapy. Patients treated with DXT and chemotherapy had had more side-effects than those treated with DXT only. Conclusion The mean age of the study population was 45 years. This was lower compared to other larger studies possibly due to younger presentation related to HIV disease. HIV positive patients with lower CD4 counts were shown to have poorer prognosis with regards to survival. HIV status was not shown to be a risk factor for recurrence. The overall survival and disease-free period at 5 years was similar to that of other international studies. Only two thirds of the patients were adequately selected for surgery according to the institution’s criteria for a Wertheim’s hysterectomy and therefore it may be necessary to reconsider the pre-operative assessment of these patients. More advanced stages, tumours ≥ 4cm, adenomatous cell type, poor differentiation, > 5mm depth of invasion, >7mm lateral spread, higher number of nodes positive for metastatic disease, surgical margins ≤ 10mm, positive lympohovascular space, parametrial and pouch of Douglas involvement were factors that had a poorer prognosis with regards to recurrence, overall survival and disease-free interval. However, the rates of recurrence were not statistically significant at a 95% confidence level.
LG2018
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Lin, Hsien-Ai, e 林仙艾. "Treatments for stage IB2 of cervical cancer –A study at medical center in central area of Taiwan". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/s3ubp5.

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碩士
東海大學
工業工程與經營資訊學系
103
Cervical cancer is the third leading cause of female cancer worldwide. It is estimated to be responsible for 530,000 new cases of cancer in 2008 (nearly one in ten (9%) of all cancers diagnosed in women). From the FIGO annual repot the average 5 year survival rate drop dramatically from 90% to 75% for stage IB1 and IB2, respectively. The treatment policy for stage IB2 is more controversial than other stages and including concomitant chemoradiation, primary radical hysterectomy with retroperitoneal lymph dissection, and concomitant chemoradiation followed by hysterectomy. Each method has their benefits and shortcomings. In treatment stage IB2 cervical cancer, neoadjuvant chemotherapy followed by radical hysterectomy will improve survival compare to operation alone. Intensity modulated radiotherapy (IMRT) and concomitant chemotherapy was found to have good efficacy at the same time favorable acute and late toxicities. Now that these two treatment strategies both offer benefits to stage IB2 cervical cancer patients, which one should be the first choice, including: radical hysterectomy, neoadjuvant chemotherapy followed by radical hysterectomy, radiotherapy, or concomitant chemoradiation therapy should be determined by clinical trials. However, from Pubmed search, there were only few studies involving the comparison of these four methods of treatment. Therefore , we hope that through this retrospective study to explore ways for the treatment of cervical cancer IB2.
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洪懿慈. "Discovery of Novel RAD 51 and NF-kB Inhibitors : IBR2 Analogues and Aminofuran fused Benzimidazole and Synthesis of Phosphonyl Pyrazole fused Benzimidazole". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/9dfyeg.

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碩士
國立交通大學
應用化學系碩博士班
100
In this thesis, we used multicomponent reactions for synthesis of different main architecture of small organic molecules and did the biological screening for anticancer activity, in order to identify the high inhibition of drug leads. This thesis can be divided into three parts: The first part reported the improvement of the synthetic approach for the assembling of IBR2 analogues. The original two steps synthetic route was improved to one pot tandem reaction and the reaction time was reduced to 30 minutes from 20 hours. Based on this efficient synthetic approach, a series of IBR2 derivatives were prepared and these IBR2 analogues were subjected to biological screening. The second part informed that the used of 2-cyanomethylbenzimidazole and 2-bromoacetophenone for cyclization reaction to synthesis the molecular library which conformation has the furan structure as well as studied the structure-activity relationship. The third part used 2-cyanomethylbenzimidazole as a starting material through condensation reaction and cyclization reaction with aldehyde and Bestmann-Ohira reagent for synthesis the molecular library which conformation has the pyrazole structure.
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Livros sobre o assunto "IB12"

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Learning to Use Office 2000 (Clait Ibt2). Heinemann Educational Publishers, 2000.

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2

Kemeny, John G., e Thomas E. Kurtz. True Basic: The Structured Language System for the Future (07-Ibm2/L, Version 2.1). 2a ed. True Basic, 1987.

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Capítulos de livros sobre o assunto "IB12"

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Wang, H. Hau, e Jack M. Williams. "Ambient-Pressure Superconducting Synthetic Metals β-(Bedt-TTF)2 X, X = I3 - , IBr2 - , and AuI2 -". In Inorganic Syntheses, 41–50. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132609.ch14.

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2

Dachir, Shlomit, Izhak Barness, Eliezer Fishbine, Jacob Meshulam, Rita Sahar, Arik Eisenkraft, Adina Amir e Tamar Kadar. "Dermostyx (IB1): High Efficacy and Safe Topical Skin Protectant Against Percutaneous Toxic Agents". In Skin Decontamination, 183–98. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24009-7_11.

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3

Song, Chaohong. "Prediction of Bacterial Toxins by Feature Representation of Position Specific Scoring Matrix and IB1 Classifier Fusion". In Communications in Computer and Information Science, 645–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19853-3_95.

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4

Whangbo, Myung-Hwan, Jack M. Williams, Arthur J. Schultz e Mark A. Beno. "Importance of Intermolecular Hydrogen — Hydrogen and Hydrogen — Anion Contacts for the Lattice Softness and the Superconductivity of β-(ET)2X (X− = I3−, AuI2−, IBr2−". In Organic and Inorganic Low-Dimensional Crystalline Materials, 333–36. New York, NY: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4899-2091-1_29.

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5

"Repair of bridge IB42 over the Limpopo river at Stockpoort border post". In Concrete Repair, Rehabilitation and Retrofitting II, 297–98. CRC Press, 2008. http://dx.doi.org/10.1201/9781439828403-113.

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Humphries, W., e E. Kruger. "Repair of bridge IB42 over the Limpopo river at Stockpoort border post". In Concrete Repair, Rehabilitation and Retrofitting II, 279–80. CRC Press, 2008. http://dx.doi.org/10.1201/9781439828403.ch101.

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VEITH, H., F. GROSS, C. P. HEIDMANN, K. ANDRES, H. FUCHS e E. AMBERGER. "MEISSNER EFFECT UNDER PRESSURE IN ORGANIC SUPERCONDUCTORS OF THE β-(BEDT-TTF)2X FAMILY (X = I3, IBr2, AuI2)". In Proceedings of the Yamada Conference XV on Physics and Chemistry of Quasi One-Dimensional Conductors, 360–62. Elsevier, 1986. http://dx.doi.org/10.1016/b978-1-4832-2812-9.50107-5.

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8

Marchocki, Zibi, e Allan Covens. "Is Radical Surgery or Parametrectomy Needed for Early-stage FIGO IA2 and Microscopic IB1 Cervical Cancer?" In 50 Big Debates in Gynecologic Oncology, 262–64. Cambridge University Press, 2023. http://dx.doi.org/10.1017/9781108935579.086.

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9

Nam, Joo-Hyun, e Jeong-Yeol Park. "Is Radical Surgery or Parametrectomy Needed for Early-stage FIGO IA2 and Microscopic IB1 Cervical Cancer?" In 50 Big Debates in Gynecologic Oncology, 259–61. Cambridge University Press, 2023. http://dx.doi.org/10.1017/9781108935579.085.

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Plante, Marie. "What is the Best Management Option for Young Women with Stage IB2 Cervical Cancer Who Wish to Preserve Fertility?" In 50 Big Debates in Gynecologic Oncology, 268–71. Cambridge University Press, 2023. http://dx.doi.org/10.1017/9781108935579.088.

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Trabalhos de conferências sobre o assunto "IB12"

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Meschini, Tommaso, Valeria Artuso, Gabriella Schivardi, Luigi Antonio De Vitis, Francesco Multinu, Nerea Martin-Calvo, Luis Chiva, Fabio Ghezzi e Jvan Casarin. "#466 Adjuvant radiation therapy for surgically staged FIGO 2018 IB1-IB2 cervical cancer: is it time for a change?" In ESGO 2023 Congress. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/ijgc-2023-esgo.146.

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Lim, Hyunji, Se Ik Kim, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Chel Hun Choi e Maria Lee. "EP075/#714 Survival outcomes from laparoscopic radical hysterectomy without preoperative cervical conization in 2018 FIGO stage IB1-IB2 cervical cancer". In IGCS 2022 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-igcs.166.

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H., Oswin Rahadiyan, Gloria Virginia e Antonius Rachmat C. "Sentiment Classification of Film Reviews Using IB1". In 2016 7th International Conference on Intelligent Systems, Modelling and Simulation (ISMS). IEEE, 2016. http://dx.doi.org/10.1109/isms.2016.38.

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Hurtado Estrada, G. "180 Modified radical hysterectomy for cervical cancer IB1". In IGCS Annual 2019 Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-igcs.180.

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Ferguson, Peter J., Morgan Black, Rene Figueredo, Mark D. Vincent e James Koropatnick. "Abstract 3057: Synergistic antiproliferative activity between anticancer drugs and RAD51 inhibitors IBR2 and IBR120". In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3057.

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Ferguson, Peter J., Morgan Black, Rene Figueredo, Mark D. Vincent e James Koropatnick. "Abstract 3057: Synergistic antiproliferative activity between anticancer drugs and RAD51 inhibitors IBR2 and IBR120". In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3057.

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Vranes, B. "P45 Pathology review of stage IA2 microinvasive and small diameter stage IB1 cervical cancer". In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.107.

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Panchbhaya, N., E. Marchand, C. Mimoun, AS Leveau Vallier, V. Place e M. Mezzadri. "EP377 Total laparoscopic radical trachelectomy with uterine arteries preservation for stage IB2 cervical cancer". In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.436.

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Kim, Sang Il, e Jisu Yun. "Robot-assisted versus conventional laparoscopic radical hysterectomy in cervical cancer stage IB1 (FIGO 2018)". In KSGO 2023. Korea: Korean Society of Gynecologic Oncology, 2023. http://dx.doi.org/10.3802/jgo.2023.34.s1.c03.

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Mandic, A., M. Davidovic Grigoraki, B. Gutić, N. Prvulović Bunović e N. Šolajić. "EP353 Fertility sparing surgery following neoadjuvant chemotherapy of cervical cancer figo stage IB2 – case report". In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.412.

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Relatórios de organizações sobre o assunto "IB12"

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Cheng, Jing, BeiBei Liu, Lin Xu, Biao Wang, XC Long, ZH Li e RT Wu. Effectiveness comparisons of various therapies for FIGO stage IB2/IIA2 cervical cancer: a Bayesian network meta‑analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, outubro de 2020. http://dx.doi.org/10.37766/inplasy2020.10.0069.

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