Conecte-se

Bibliografias temáticas / Human-relevant / Artigos de revistas

Artigos de revistas sobre o tema "Human-relevant"

Siga este link para ver outros tipos de publicações sobre o tema: Human-relevant.

Autor: Grafiati

Publicado: 26 de julho de 2024

Última modificação: 27 de julho de 2024

Crie uma referência precisa em APA, MLA, Chicago, Harvard, e outros estilos

Selecione um tipo de fonte:

Veja os 50 melhores artigos de revistas para estudos sobre o assunto "Human-relevant".

Ao lado de cada fonte na lista de referências, há um botão "Adicionar à bibliografia". Clique e geraremos automaticamente a citação bibliográfica do trabalho escolhido no estilo de citação de que você precisa: APA, MLA, Harvard, Chicago, Vancouver, etc.

Você também pode baixar o texto completo da publicação científica em formato .pdf e ler o resumo do trabalho online se estiver presente nos metadados.

Veja os artigos de revistas das mais diversas áreas científicas e compile uma bibliografia correta.

1

Nasimi Chingizzadeh, Chingiz. "HUMAN RIGHTS RELEVANT TO TRADEMARKS". ANCIENT LAND 03, n.º 04 (30 de junho de 2021): 19–21. http://dx.doi.org/10.36719/2706-6185/03/19-21.

Texto completo da fonte

Resumo:

Human rights and trademark laws do not go well together. This is partly the result of an educational tradition and the division of legal research into private and commercial law on the one hand and public law, international law and human rights law on the other. This division is also reinforced by the historical judiciary in many countries. However, human rights concerns are becoming more and more relevant in trademark law. Keywords: Intellectual property, trademark, human rights, freedom of expression, privacy, property

Estilos ABNT, Harvard, Vancouver, APA, etc.

2

Boring, Ronald L., Emilie Roth, Oliver Straeter, Karin Laumann, Harold S. Blackman, Johanna Oxstrand e Julius J. Persensky. "Is Human Reliability Relevant to Human Factors?" Proceedings of the Human Factors and Ergonomics Society Annual Meeting 53, n.º 10 (outubro de 2009): 610–14. http://dx.doi.org/10.1177/154193120905301006.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

3

Bresciani, Katia Denise S., André Luiz B. Galvão, Amanda L. de Vasconcellos, José Antonio Soares, Lucas Vinicius Shigaki de Matos, Julia Cestari Pierucci, Luiz da Silveira Neto et al. "Relevant aspects of human toxoplasmosis". Research Journal of Infectious Diseases 1, n.º 1 (2013): 7. http://dx.doi.org/10.7243/2052-5958-1-7.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

4

Chingizzadeh, Chingiz. "HUMAN RIGHTS RELEVANT TO TRADEMARKS". ANCIENT LAND 3, n.º 4 (19 de abril de 2021): 21–24. http://dx.doi.org/10.36719/2706-6185/06/21-24.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

5

Dhobale, Manisha Randhir, Nitin Radhakishan Mudiraj e Medha Girish Puranik. "CLINICALLY RELEVANT MORPHOMETRIC STUDY OF LEFT CORONARY ARTERY IN ADULT HUMAN CADAVERS". International Journal of Anatomy and Research 6, n.º 3.3 (5 de setembro de 2018): 5605–12. http://dx.doi.org/10.16965/ijar.2018.290.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

6

Speers, Marjorie A. "Human Research Accreditation Relevant to Anthropology". Anthropology News 45, n.º 6 (setembro de 2004): 27. http://dx.doi.org/10.1111/an.2004.45.6.27.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

7

Avanzini, G. "Animal models relevant to human epilepsies". Italian Journal of Neurological Sciences 16, n.º 1-2 (março de 1995): 5–8. http://dx.doi.org/10.1007/bf02229068.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

8

Rizzo, Carmen, Giuseppa Genovese, Marina Morabito, Caterina Faggio, Maria Pagano, Antonio Spanò, Vincenzo Zammuto et al. "Potential Antibacterial Activity of Marine Macroalgae against Pathogens Relevant for Aquaculture and Human Health". Journal of Pure and Applied Microbiology 11, n.º 4 (30 de dezembro de 2017): 1695–706. http://dx.doi.org/10.22207/jpam.11.4.07.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

9

Carpenter, Richard, e Hui-Wen Lo. "STAT3 Target Genes Relevant to Human Cancers". Cancers 6, n.º 2 (16 de abril de 2014): 897–925. http://dx.doi.org/10.3390/cancers6020897.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

10

Hall, Judith G. "How imprinting is relevant to human disease". Development 108, Supplement (1 de abril de 1990): 141–48. http://dx.doi.org/10.1242/dev.108.supplement.141.

Texto completo da fonte

Resumo:

Genomic imprinting appears to be a ubiquitous process in mammals involving many chromosome segments whose affects are dependent on their parental origin. One of the challenges for clinical geneticists is to determine which disorders are manifesting imprinting effects and which families are affected. Re-evaluation of cases of chromosomal abnormalities and family histories of disease manifestations should give important clues. Examination of the regions of human chromosomes homologous to mouse imprinted chromosomal regions may yield useful information. Cases of discordance in monozygous twins may also provide important insights into imprinted modification of diseases.

Estilos ABNT, Harvard, Vancouver, APA, etc.

11

Martin, Paul J. "Animal experimentation relevant to human marrow transplantation". Current Opinion in Oncology 4, n.º 2 (abril de 1992): 239–46. http://dx.doi.org/10.1097/00001622-199204000-00002.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

12

Gao, Xiao, Jie Ling, Xiaohui Xiao e Miao Li. "Learning Force-Relevant Skills from Human Demonstration". Complexity 2019 (3 de fevereiro de 2019): 1–11. http://dx.doi.org/10.1155/2019/5262859.

Texto completo da fonte

Resumo:

Many human manipulation skills are force relevant, such as opening a bottle cap and assembling furniture. However, it is still a difficult task to endow a robot with these skills, which largely is due to the complexity of the representation and planning of these skills. This paper presents a learning-based approach of transferring force-relevant skills from human demonstration to a robot. First, the force-relevant skill is encapsulated as a statistical model where the key parameters are learned from the demonstrated data (motion, force). Second, based on the learned skill model, a task planner is devised which specifies the motion and/or the force profile for a given manipulation task. Finally, the learned skill model is further integrated with an adaptive controller that offers task-consistent force adaptation during online executions. The effectiveness of the proposed approach is validated with two experiments, i.e., an object polishing task and a peg-in-hole assembly.

Estilos ABNT, Harvard, Vancouver, APA, etc.

13

Wardle, E. N. "Endothelial cell antibodies: relevant in human disease?" Nephrology Dialysis Transplantation 10, n.º 4 (abril de 1995): 577–78. http://dx.doi.org/10.1093/ndt/10.4.577b.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

14

Spencer, Sean P., Gabriela K. Fragiadakis e Justin L. Sonnenburg. "Pursuing Human-Relevant Gut Microbiota-Immune Interactions". Immunity 51, n.º 2 (agosto de 2019): 225–39. http://dx.doi.org/10.1016/j.immuni.2019.08.002.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

15

Savalli, Carine, Maria M. Brandão, Thais S. Domingues, Maria A. Honório e César Ades. "Dog-Human communication through a keyboard: Is human attentional state relevant?" Journal of Veterinary Behavior 4, n.º 2 (março de 2009): 55. http://dx.doi.org/10.1016/j.jveb.2008.09.054.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

16

Grohsjean, Thorsten, e David Kryscynski. "Origins of strategically relevant firm-specific human capital". Academy of Management Proceedings 2018, n.º 1 (agosto de 2018): 11692. http://dx.doi.org/10.5465/ambpp.2018.11692abstract.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

17

Nikas, G. "Cell-surface morphological events relevant to human implantation". Human Reproduction 14, suppl 2 (1 de dezembro de 1999): 37–44. http://dx.doi.org/10.1093/humrep/14.suppl_2.37.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

18

Ram, Rebecca. "Launch of the Alliance for Human Relevant Science". Alternatives to Laboratory Animals 45, n.º 1 (março de 2017): 49–53. http://dx.doi.org/10.1177/026119291704500109.

Texto completo da fonte

Resumo:

The Alliance is an exciting new collaboration, founded to address an urgent need to drive research and development, policymaking, awareness, outreach, and education into human-based methods of safety testing and biomedical research

Estilos ABNT, Harvard, Vancouver, APA, etc.

19

SANZ, INAKI, LARN-YUAN HWANG, CHARLES HASEMANN, JAMES THOMAS, RICHARD WASSERMAN, PHILIP TUCKER e J. DONALD CAPRA. "Polymorphisms of Immunologically Relevant Loci in Human Disease." Annals of the New York Academy of Sciences 546, n.º 1 Molecular Bas (dezembro de 1988): 133–42. http://dx.doi.org/10.1111/j.1749-6632.1988.tb21628.x.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

20

Battino, Maurizio, Jules Beekwilder, Beatrice Denoyes-Rothan, Margit Laimer, Gordon J. McDougall e Bruno Mezzetti. "Bioactive compounds in berries relevant to human health". Nutrition Reviews 67 (maio de 2009): S145—S150. http://dx.doi.org/10.1111/j.1753-4887.2009.00178.x.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

21

Emery Thompson, Melissa, Alexandra G. Rosati e Noah Snyder-Mackler. "Insights from evolutionarily relevant models for human ageing". Philosophical Transactions of the Royal Society B: Biological Sciences 375, n.º 1811 (21 de setembro de 2020): 20190605. http://dx.doi.org/10.1098/rstb.2019.0605.

Texto completo da fonte

Resumo:

As the world confronts the health challenges of an ageing population, there has been dramatically increased interest in the science of ageing. This research has overwhelmingly focused on age-related disease, particularly in industrialized human populations and short-lived laboratory animal models. However, it has become clear that humans and long-lived primates age differently than many typical model organisms, and that many of the diseases causing death and disability in the developed world are greatly exacerbated by modern lifestyles. As such, research on how the human ageing process evolved is vital to understanding the origins of prolonged human lifespan and factors increasing vulnerability to degenerative disease. In this issue, we highlight emerging comparative research on primates, highlighting the physical, physiological, behavioural and cognitive processes of ageing. This work comprises data and theory on non-human primates, as well as under-represented data on humans living in small-scale societies, which help elucidate how environment shapes senescence. Component papers address (i) the critical processes that comprise senescence in long-lived primates; (ii) the social, ecological or individual characteristics that predict variation in the pace of ageing; and (iii) the complicated relationship between ageing trajectories and disease outcomes. Collectively, this work provides essential comparative, evolutionary data on ageing and demonstrates its unique potential to inform our understanding of the human ageing process. This article is part of the theme issue ‘Evolution of the primate ageing process’.

Estilos ABNT, Harvard, Vancouver, APA, etc.

22

Blendy, Julie A. "Modeling Neuropsychiatric Disease-Relevant Human SNPs in Mice". Neuropsychopharmacology 36, n.º 1 (30 de novembro de 2010): 364–65. http://dx.doi.org/10.1038/npp.2010.143.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

23

Borgert, Christopher J., John C. Matthews e Stephen P. Baker. "Human-relevant potency threshold (HRPT) for ERα agonism". Archives of Toxicology 92, n.º 5 (9 de abril de 2018): 1685–702. http://dx.doi.org/10.1007/s00204-018-2186-z.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

24

Lavery, W. Lindsay. "How relevant are animal models to human ageing?" Journal of the Royal Society of Medicine 93, n.º 6 (junho de 2000): 296–98. http://dx.doi.org/10.1177/014107680009300605.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

25

Jacobs, Gordon B., Tetsuzo Agishi, Robert Ecker, Thomas Meaney, Raymond J. Kiraly e Yukihiko Nosé. "Human Thoracic Anatomy Relevant to Implantable Artificial Hearts". Artificial Organs 2, n.º 1 (12 de novembro de 2008): 64–82. http://dx.doi.org/10.1111/j.1525-1594.1978.tb01005.x.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

26

Mooney, S. D., e R. B. Altman. "MutDB: annotating human variation with functionally relevant data". Bioinformatics 19, n.º 14 (22 de setembro de 2003): 1858–60. http://dx.doi.org/10.1093/bioinformatics/btg241.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

27

Mills, Melody, e Mary K. Estes. "Physiologically relevant human tissue models for infectious diseases". Drug Discovery Today 21, n.º 9 (setembro de 2016): 1540–52. http://dx.doi.org/10.1016/j.drudis.2016.06.020.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

28

Wrobel, Sonja. "222b - Relevant information and challenges for human biomonitoring". Annals of Work Exposures and Health 68, Supplement_1 (1 de junho de 2024): 1. http://dx.doi.org/10.1093/annweh/wxae035.159.

Texto completo da fonte

Resumo:

Abstract Human biomonitoring (HBM) has proven to be a useful tool to perform risk assessment of chemicals. Nevertheless, certain criteria for a reliable HBM should be taken into account. Knowledge regarding the suitability of the chosen biological matrix, as well as the specificity and sensitivity of biomarkers is essential. For a specific HBM, the biomarker must not be formed from other substances with expected exposures. The sensitivity of the biomarker depends on the aim of the study with higher sensitivities needed for the investigation of background exposures in the general population, compared to verifying the adherence to health-based guidance values (e.g., in an occupational context). Furthermore, aspects of analytical ruggedness of the biomarkers need to be considered, such as susceptibility to pre-analytical contamination. To obtain valid HBM results, analytical methods for these biomarkers need to be sufficiently sensitive, selective, and rugged and need to be applied under quality-assured conditions. In this presentation, the choice of a reliable biomarker will be discussed using practical examples.

Estilos ABNT, Harvard, Vancouver, APA, etc.

29

Doyle, Brian. "Book Review: Human Rights and Disabled Persons: Essays and Relevant Human Rights Instruments". International Journal of Discrimination and the Law 1, n.º 3 (março de 1996): 295–99. http://dx.doi.org/10.1177/135822919600100308.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

30

Hoogensen, GunhildBazely,. "Human Security in the Arctic - Yes, It Is Relevant!" Journal of Human Security 5, n.º 2 (2009): 1–10. http://dx.doi.org/10.3316/jhs0502001.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

31

Jung, Hee-Won. "Frailty as a Clinically Relevant Measure of Human Aging". Annals of Geriatric Medicine and Research 25, n.º 3 (30 de setembro de 2021): 139–40. http://dx.doi.org/10.4235/agmr.21.0106.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

32

Somepalli, Gowthami, Sarthak Sahoo, Arashdeep Singh e Sridhar Hannenhalli. "Prioritizing and characterizing functionally relevant genes across human tissues". PLOS Computational Biology 17, n.º 7 (16 de julho de 2021): e1009194. http://dx.doi.org/10.1371/journal.pcbi.1009194.

Texto completo da fonte

Resumo:

Knowledge of genes that are critical to a tissue’s function remains difficult to ascertain and presents a major bottleneck toward a mechanistic understanding of genotype-phenotype links. Here, we present the first machine learning model–FUGUE–combining transcriptional and network features, to predict tissue-relevant genes across 30 human tissues. FUGUE achieves an average cross-validation auROC of 0.86 and auPRC of 0.50 (expected 0.09). In independent datasets, FUGUE accurately distinguishes tissue or cell type-specific genes, significantly outperforming the conventional metric based on tissue-specific expression alone. Comparison of tissue-relevant transcription factors across tissue recapitulate their developmental relationships. Interestingly, the tissue-relevant genes cluster on the genome within topologically associated domains and furthermore, are highly enriched for differentially expressed genes in the corresponding cancer type. We provide the prioritized gene lists in 30 human tissues and an open-source software to prioritize genes in a novel context given multi-sample transcriptomic data.

Estilos ABNT, Harvard, Vancouver, APA, etc.

33

Ryu, Hyun-Wook, Dong Hoon Lee, Hye-Rim Won, Kyeong Hwan Kim, Yun Jeong Seong e So Hee Kwon. "Influence of Toxicologically Relevant Metals on Human Epigenetic Regulation". Toxicological Research 31, n.º 1 (31 de março de 2015): 1–9. http://dx.doi.org/10.5487/tr.2015.31.1.001.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

34

Pacione, Michael. "The relevance of religion for a relevant human geography". Scottish Geographical Journal 115, n.º 2 (janeiro de 1999): 117–31. http://dx.doi.org/10.1080/14702549908553821.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

35

Kryscynski, David, e Dave Ulrich. "Making Strategic Human Capital Relevant: A Time-Sensitive Opportunity". Academy of Management Perspectives 29, n.º 3 (agosto de 2015): 357–69. http://dx.doi.org/10.5465/amp.2014.0127.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

36

Chin, Benjamin M., e Johannes Burge. "Human sensitivity to task-relevant features in speed discrimination". Journal of Vision 19, n.º 10 (6 de setembro de 2019): 168b. http://dx.doi.org/10.1167/19.10.168b.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

37

Tully, C. J. "Information, Human Activity and the Nature of Relevant Theories". Computer Journal 28, n.º 3 (1 de março de 1985): 206–10. http://dx.doi.org/10.1093/comjnl/28.3.206.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

38

Ferrone, Soldano, e Giuseppe Sconocchia. "A clinically relevant mouse model of human multiple myeloma?" Blood 106, n.º 2 (15 de julho de 2005): 388–89. http://dx.doi.org/10.1182/blood-2005-04-1676.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

39

Zivin, J. A., e J. C. Grotta. "Animal stroke models. They are relevant to human disease." Stroke 21, n.º 7 (julho de 1990): 981–83. http://dx.doi.org/10.1161/01.str.21.7.981.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

40

Fussell, Karma C., Steffen Schneider, Stephanie Melching-Kollmuss, Sibylle Groeters, Volker Strauss, Benazir Siddeek, Mohamed Benahmed, Markus Frericks e Bennard van Ravenzwaay. "Testing mixtures in vivo at human-relevant exposure levels". Toxicology Letters 221 (agosto de 2013): S25. http://dx.doi.org/10.1016/j.toxlet.2013.06.088.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

41

Hanington, Bruce M. "Relevant and Rigorous: Human-Centered Research and Design Education". Design Issues 26, n.º 3 (julho de 2010): 18–26. http://dx.doi.org/10.1162/desi_a_00026.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

42

van Thriel, Christoph. "Aluminium affects neurospheres at human in vivo relevant concentrations". Archives of Toxicology 94, n.º 10 (25 de agosto de 2020): 3601–2. http://dx.doi.org/10.1007/s00204-020-02889-x.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

43

Snyder, Jason S., e Heather A. Cameron. "Could adult hippocampal neurogenesis be relevant for human behavior?" Behavioural Brain Research 227, n.º 2 (fevereiro de 2012): 384–90. http://dx.doi.org/10.1016/j.bbr.2011.06.024.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

44

Yadav, Pramod Kumar, Victor Vitvitsky, Sebastián Carballal, Javier Seravalli e Ruma Banerjee. "Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations". Journal of Biological Chemistry 295, n.º 19 (16 de março de 2020): 6299–311. http://dx.doi.org/10.1074/jbc.ra120.012616.

Texto completo da fonte

Resumo:

3-Mercaptopyruvate sulfur transferase (MPST) catalyzes the desulfuration of 3-mercaptopyruvate (3-MP) and transfers sulfane sulfur from an enzyme-bound persulfide intermediate to thiophilic acceptors such as thioredoxin and cysteine. Hydrogen sulfide (H2S), a signaling molecule implicated in many physiological processes, can be released from the persulfide product of the MPST reaction. Two splice variants of MPST, differing by 20 amino acids at the N terminus, give rise to the cytosolic MPST1 and mitochondrial MPST2 isoforms. Here, we characterized the poorly-studied MPST1 variant and demonstrated that substitutions in its Ser–His–Asp triad, proposed to serve a general acid–base role, minimally affect catalytic activity. We estimated the 3-MP concentration in murine liver, kidney, and brain tissues, finding that it ranges from 0.4 μmol·kg−1 in brain to 1.4 μmol·kg−1 in kidney. We also show that N-acetylcysteine, a widely-used antioxidant, is a poor substrate for MPST and is unlikely to function as a thiophilic acceptor. Thioredoxin exhibits substrate inhibition, increasing the KM for 3-MP ∼15-fold compared with other sulfur acceptors. Kinetic simulations at physiologically-relevant substrate concentrations predicted that the proportion of sulfur transfer to thioredoxin increases ∼3.5-fold as its concentration decreases from 10 to 1 μm, whereas the total MPST reaction rate increases ∼7-fold. The simulations also predicted that cysteine is a quantitatively-significant sulfane sulfur acceptor, revealing MPST's potential to generate low-molecular-weight persulfides. We conclude that the MPST1 and MPST2 isoforms are kinetically indistinguishable and that thioredoxin modulates the MPST-catalyzed reaction in a physiologically-relevant concentration range.

Estilos ABNT, Harvard, Vancouver, APA, etc.

45

Su, Mack Y., Laurie A. Steiner, Hannah Bogardus, Tejaswini Mishra, Vincent P. Schulz, Ross C. Hardison e Patrick G. Gallagher. "Identification of Biologically Relevant Enhancers in Human Erythroid Cells". Journal of Biological Chemistry 288, n.º 12 (22 de janeiro de 2013): 8433–44. http://dx.doi.org/10.1074/jbc.m112.413260.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

46

Su, Mack, Laurie A. Steiner, Hannah Bogardus, Vincent P. Schulz, Ross C. Hardison e Patrick G. Gallagher. "Identification of Biologicaly Relevant Enhancers in Human Erythroid Cells". Blood 120, n.º 21 (16 de novembro de 2012): 368. http://dx.doi.org/10.1182/blood.v120.21.368.368.

Texto completo da fonte

Resumo:

Abstract Abstract 368 Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Recent studies utilizing genomic methodologies have shown that enhancers are frequently associated with biologically relevant and disease-associated genetic variants. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypothesized that a unique set of enhancers regulate gene expression in human erythroid cells, a highly specialized cell type evolved to provide adequate amounts of oxygen throughout the body. Using chromatin immunoprecipitation followed by massively parallel sequencing, genome-wide maps of candidate enhancers were constructed for p300 and four transcription factors, GATA1, NF-E2, KLF1, and SCL, in primary human erythroid cells. These data were combined with parallel gene expression analyses and candidate enhancers identified. Cell and tissue-type specific enhancers act over distances of tens to hundreds of kilobases, thus bona fide erythroid enhancers are expected to be enriched in the genomic vicinity of genes expressed and functional in erythroid cells. Sites of occupancy were correlated with levels of gene expression. Promoter sites within 2kb of annotated transcriptional start sites (TSS) were excluded. Consistent with their predicted function, there was significant enrichment of p300 peaks within 2–50kb of the TSS of genes highly expressed in erythroid cells c.f. peaks >100kb of a TSS. There was also significant enrichment of combinations of 2, 3, and 4 co-localizing erythroid transcription factor peaks within 2–50kb of the TSS of genes highly expressed in erythroid cells. In contrast, similar to other cell type-specific enhancers, there was no enrichment of p300 or erythroid transcription factor sites within 2–50kb of genes highly expressed in nonerythroid cells. When analyses were performed comparing a set of erythroid-specific genes vs. a random set of genes, there was significant enrichment of combinations of 2, 3, and 4 co-localizing erythroid transcription factor binding sites, but not p300, within 2–50kb of the TSS of erythroid-specific genes. Evolutionary analyses revealed high conservation between man and chimp for p300 and erythroid transcription factors. However, there was a very large falloff between human and mouse, with. Disclosures: No relevant conflicts of interest to declare.

Estilos ABNT, Harvard, Vancouver, APA, etc.

47

Steinberg, Daniel, e Joseph L. Witztum. "Is the Oxidative Modification Hypothesis Relevant to Human Atherosclerosis?" Circulation 105, n.º 17 (30 de abril de 2002): 2107–11. http://dx.doi.org/10.1161/01.cir.0000014762.06201.06.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

48

Opelz, Gerhard, e Frans H. J. Claas. "Which human leukocyte antigen antibodies are really clinically relevant?" Human Immunology 70, n.º 8 (agosto de 2009): 561–62. http://dx.doi.org/10.1016/j.humimm.2009.06.019.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

49

Atanasova, Srebrena, Markus Hirschburger, Danny Jonigk, Martin Obert, Kathrin Petri, Alena Evers, Andreas Hecker et al. "A relevant experimental model for human bronchiolitis obliterans syndrome". Journal of Heart and Lung Transplantation 32, n.º 11 (novembro de 2013): 1131–39. http://dx.doi.org/10.1016/j.healun.2013.07.016.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

50

Khabieva, Zaira Dokuevna, Leyla Alievna Gadzhialieva e Magomedrasul Magomediminovich Alibekov. "IMPROVING HUMAN RESOURCE MANAGEMENT BASED ON RELEVANT HR REFORMS". Industrial Economics 7, n.º 5 (2022): 659–63. http://dx.doi.org/10.47576/2712-7559_2022_5_7_659.

Texto completo da fonte

Estilos ABNT, Harvard, Vancouver, APA, etc.

Oferecemos descontos em todos os planos premium para autores cujas obras estão incluídas em seleções literárias temáticas. Contate-nos para obter um código promocional único!