Teses / dissertações sobre o tema "Human Development – physiology"
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McElroy, Mary Catherine. "The role of antioxidant enzymes in human lung development". Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293725.
Texto completo da fonteParker, Dawn Fiona. "Factors controlling the development and strength of human skeletal muscle". Thesis, University College London (University of London), 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244016.
Texto completo da fonteKuo, Hongqi. "Nuclear and chromosomal abnormalities in human preimplantation development in vitro". Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251676.
Texto completo da fonteFryer, Anthony Alan. "Studies on the biochemical development of human lung and brain". Thesis, Keele University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306225.
Texto completo da fonteBucklow, C. W. M. "English science and the development of plant physiology in the second half of the seventeenth century". Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371615.
Texto completo da fonteZhu, Meidong. "Development and regression of the human hyaloid system". Thesis, Sydney Medical School, 1998. http://hdl.handle.net/2123/14472.
Texto completo da fonteXu, Li Jing. "Oxygen and lung development in newborn rats and chick embryos". Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61955.
Texto completo da fonteChandaria, Rehma. "Scaffold development to engineer human intestinal epithelial tissue grafts". Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/41875/.
Texto completo da fonteAhmad, Mehtab. "Interleukin-1α as a biomarker of human abdominal aortic aneurysm (AAA) development and progression". Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7712/.
Texto completo da fonteCavilla, Jennifer Louise. "The effects of factors influencing human oocyte maturation upon fertilization and preimplantation embryo development". Thesis, University of Warwick, 2002. http://wrap.warwick.ac.uk/73509/.
Texto completo da fonteSingh, Harsimrat. "Development of EEG based BCI approaches for detection of awareness in human disorders of consciousness". Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/3790/.
Texto completo da fonteMold, Jeffrey Eron. "The development of the human adaptive immune system and its role in promoting immunological tolerance". Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3352466.
Texto completo da fonteAl-Sho'ala, Afaf Sayed Ali. "Evaluation of wet bulb globe temperature index for a population adapted to work in the heat : and development of a heat stress limit for occupational accident prevention predicted from meteorological data and building design". Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339094.
Texto completo da fonteKanady, John. "Morphogenesis of lymphatic vascular networks| Insights from connexin and Foxc2 knockout mice". Thesis, The University of Arizona, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3671779.
Texto completo da fonteTo maintain human health, the lymphatic system requires a structurally and functionally sound network of lymph vessels to absorb lipid-based nutrients, preserve extracellular fluid homeostasis, and mediate immune responses. Aside from lymphedema, investigations in the past few decades have found that impairment of the lymphatic vasculature is also involved in processes such as inflammation, tumor metastasis, fat metabolism, and obesity. However, despite a long history of study and rekindled vigor in the field of lymphatic vascular research, our knowledge of lymph vessel development and physiology is still quite limited. Recently, mutations in a protein family known as connexins (Cxs) were identified as the cause of lymphatic dysfunction in some cases of inherited lymphedema. This dissertation explores the role of primarily two specific connexins, Cx37 and Cx43, and the transcription factor Foxc2 in the morphogenesis and function of the lymphatic vasculature in mice. To accomplish this, phenotypic characterization of mice with genetic deficiencies (knockout mice) in Cx37, Cx43, and/or Foxc2 was performed principally via necropsy, histological techniques (immuno-fluorescence microscopy and H&E staining), and Evans blue dye (EBD) injections. Developmental abnormalities were found in lymphatic vascular growth, patterning, and remodeling in mice lacking Cx37, Cx43, Foxc2 or a combined deficiency of these proteins. Reductions or complete loss of lymphatic valves were a common finding in mice lacking one or more of these proteins. These valve deficits underlay lymphatic insufficiencies that resulted in lymphedema and chylothorax in some genotypes. Foxc2 was found to be a regulator of Cx37 expression. Moreover, Foxc2 was also dependent on Cx37 function for proper morphogenesis of lymph vessels. These findings pertaining to the expression of connexins in the lymphatic vasculature, their role in lymphatic valvulogenesis, and the interdependence of Cx37 and Foxc2 during lymph-vascular development represent my original contributions to human knowledge.
Khalil, Omari S. "Effects on brain development of prenatal inhibition of Kynurenine-3-Monooxygenase". Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5075/.
Texto completo da fonteScott, Ryan 1981. "Investigating the natural history of human islet-derived duct-like structures transplanted subcutaneously into nude mice". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112362.
Texto completo da fonteHuman islet derived duct-like structures from three cadaver pancreases were subcutaneously transplanted into 6-8 week old male HSD athymic nude-Foxn1 mice. Six mice were sacrificed at day 3, 7, 14 and 21 from each time period. DLS were also placed in matrigel for in-vitro control samples. DLS were processed for immunohistochemistry for endocrine markers, epithelial markers, cell death and proliferation markers, islet maturation markers and angiogenic factors.
Our results show that as DLS are transplanted, there is an increase in cell death and proliferation. This increase in cell death and proliferation causes an increase in PDX-1 expression as well as VEGF, an angiogenic factor. But over time, transplanted DLS do not show an increase in cell death and show a small decrease in cell proliferation from pre-transplanted DLS. At day 3 of engraftment, DLS show a significant expression of PDX-1. We see a small increase in endocrine tissue after 3 days of transplantation, then an increase in endocrine cell death, which returns the percentage of endocrine cells back to pre-transplantation levels at day 21. DLS were shown to express VEGF, and once transplanted into an initial hypoxic environment there is a substantial increase in expression, followed by a recruitment of microvessels. Although there is a dynamic change in expression of cell markers throughout engraftment, there is no significant change in DLS size, nuclei per DLS or cell morphology over time.
DLS have been shown to survive subcutaneous transplantation and possess an initial increase in cell proliferation leading to increases in PDX-1 and VEGF expression. Transplanted DLS have shown to possess significant angiogenic properties with the recruitment of microvessels into subcutaneous DLS grafts. Subcutaneous DLS transplantation could be used in combination with islet transplantation to alleviate current problems with islet transplantation such as islet cell death and insufficient blood supply.
Byrd, Alyson. "Evidence for a receptor binding 24R, 25-dihydroxyvitamin D3 in developing bone". Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21519.
Texto completo da fontepBDGal4-hRXRalpha bait was used to screen neonate and embryonal mandible/calvaria cDNA libraries using the yeast two-hybrid system. PCR screening was also performed using primers from the zinc-finger region of the VDR. To date no positive clones have been identified. Isolation of this putative receptor will provide valuable insight into the mechanism of this metabolite's role in bone development.
Willerton, Louise. "Gene expression in mouse testis during development". Thesis, Connect to electronic version, 2003. http://theses.gla.ac.uk:82/theses/available/etd-07042003-142909/.
Texto completo da fontePh. D. thesis submitted to the Faculty of Veterinary Medicine, University of Glasgow, 2003. Includes bibliographical references. Electronic version also available via Glasgow University e-Theses service.
Middlebrook, Aaron J. "Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture". Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280628.
Texto completo da fonteLiu, Yanhe. "Human oocytes and embryos viewed by time-lapse videography, and the development of an embryo deselection model". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2016. https://ro.ecu.edu.au/theses/1787.
Texto completo da fonteWright, Audrey F. "The influence of gender and sex hormones in the development of translational and experimental pulmonary arterial hypertension". Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5209/.
Texto completo da fonteSingh, Sally. "Development of a 10 metre shuttle walking test to access patients with chronic airways limitation". Thesis, Loughborough University, 1993. https://dspace.lboro.ac.uk/2134/6754.
Texto completo da fontePelland, Lucie. "Strategies for motor control analysis in children". Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37808.
Texto completo da fonteNegrey, John Patrick. "The effect of dietary methylmercury on Na+,K+-ATPase activity and growth in fall-run chinook salmon (O. tshawytscha) from California's Central Valley". Thesis, San Jose State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1552274.
Texto completo da fonteHatchery reared Chinook salmon from California’s Central Valley were fed for 67 days (Apr-Jun, 2008) on fish pellets mixed with either 0, 1, 3, or 5 µg·g−1 methylmercury hydroxide. Weight, fork length, condition factor, and Na+,K+-ATPase measurements were determined every two weeks and a 96-h seawater challenge was conducted at the conclusion of the experiment.
Results from two-way ANOVA, with treatment and date as independent variables, indicated no significant differences for weight (F3,32 = 1.38; P = 0.280), length (F3,32 = 0.986; P = 0.412) and condition factor (F3,32 = 0.239; P = 0.869). Post-hoc analysis following two-way ANOVA indicated mean ATPase activity in the high (x¯ = 3.08, S.E. = 0.19; P = 0.008) and medium treatments (x¯ = 2.86, S.E. = 0.57; P = 0.017) was significantly increased in early May compared with the control group (x¯ = 1.47, S.E. = 0.34). The results from the 96 h seawater challenge were consistent with those of other studies indicating weight has the greatest influence for survival in the transition from freshwater to seawater. Overall, results from this study indicated methylmercury, a known neurotoxin, altered ATPase activity in fall-run Chinook but did not significantly affect mortality in the transition from freshwater to seawater.
Valls, Margarit Maria. "Development of an advanced 3D culture system for human cardiac tissue engineering". Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/458734.
Texto completo da fonteLa cardiopatia isquèmica és una de les principals causes de mort a nivell mundial. Exceptuant el trasplantament de cor, les teràpies actuals són insuficients per restablir la funció cardíaca. Per tant, cal desenvolupar teràpies alternatives que fomentin la regeneració i/o reparació del cor, així com també noves eines per estudiar la fisiologia i fisiopatologia cardíaca in vitro. Una de les estratègies més prometedores és l’enginyeria tissular cardíaca, ja que té com a finalitat generar constructes de teixit cardíac que mimetitzin el teixit real. Aquests constructes podrien utilitzar-se com a models in vitro del miocardi humà i també com a empelts per reparar el cor malmès. Per obtenir constructes de teixit cardíac humà cal reproduir l’entorn cardíac real. Una de les estratègies més habituals consisteix en sembrar cardiomiòcits en una estructura 3D (bastida), i després cultivar el constructe en un sistema de senyalització biomimètic, normalment un bioreactor. Tanmateix, generar constructes grans i semblants al miocardi humà adult a partir de cardiomiòcits humans derivats de cèl·lules mare de pluripotència induïda (hiPSC-CM) segueix sent un repte. Així doncs, la hipòtesi d’estudi és que combinant hiPSC-CM amb una bastida 3D i estímuls biofísics adequats, es podrien generar constructes de teixit cardíac semblants al miocardi humà tant a nivell estructural com funcional. Per abordar la hipòtesi, en aquest treball s’ha caracteritzat una bastida 3D constituïda principalment per col·lagen i s’ha definit un mètode eficient per sembrar cardiomiòcits dins l’estructura. A més a més, s’ha desenvolupat un bioreactor de perfusió de sistema en paral·lel que assegura un transport de massa efectiu entre les cèl·lules i el medi de cultiu. També s’ha dissenyat una càmera de perfusió que inclou elèctrodes per estimular elèctricament les cèl·lules durant el cultiu, així com també per monitorar la funció del teixit artificial. Amb aquest avançat sistema de cultiu, s’han generat constructes de teixit cardíac humà 3D amb una funcionalitat semblant a la del teixit real. A més a més, el sistema ha permès monitorar l’electrofisiologia del teixit artificial en temps real, així com també demostrar el paper crucial de l’estimulació elèctrica per obtenir constructes amb una funcionalitat òptima.
Araghi-Niknam, Moshen 1960. "Effects of dehydroepiandrosterone supplementation in aged humans and C57BL/6 mice". Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282417.
Texto completo da fonteSchrader, Lauran N. "Does ANA-positive SLE human serum promote development of Libman-Sacks endocarditis in the NP-SLE Lewis rat model?" Muncie, IN : Ball State University, 2009. http://cardinalscholar.bsu.edu/675.
Texto completo da fonteDetton, Alan James. "The Creation of a 3D Interactive Human Neural Development Resource and Its Evaluation Through a Video Analytic Usability Study". The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337966847.
Texto completo da fonteMilliken, Laura Ann 1970. "Bone mineral density, bone remodeling, insulin-like growth factors, hormone replacement therapy, and exercise training in postmenopausal women". Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282746.
Texto completo da fonteKolatorowicz, Adam. "Patterns of Morphological Integration in Modern Human Crania: Evaluating Hypotheses of Modularity using Geometric Morphometrics". The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429881785.
Texto completo da fonteGoliath, Jesse Roberto. "A 3D Morphological Analysis of the Ontogenetic Patterning of Human Subchondral Bone Microarchitecture in the Proximal Tibia". The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1494273830449469.
Texto completo da fonteRyan, Helen Joanne. "The development of a reliable and valid netball intermittent activity test : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Sport and Exercise Science at Massey University, Auckland, New Zealand". Massey University, 2009. http://hdl.handle.net/10179/1130.
Texto completo da fonteBernabeu, Llinares Miguel Oscar. "An open source HPC-enabled model of cardiac defibrillation of the human heart". Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:9ca44896-8873-4c91-9358-96744e28d187.
Texto completo da fonteRahim, Mir Munir Ahmed 1975. "Pathogenesis of HIV-1 nef in adult mice". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115698.
Texto completo da fonteQuirk, Calvin. "Development of a Method to Assess the Impact of Saline Infusion on Venous Physiology and Injury in Humans". Thesis, Griffith University, 2021. http://hdl.handle.net/10072/405192.
Texto completo da fonteThesis (Masters)
Master of Medical Research (MMedRes)
School of Pharmacy & Med Sci
Griffith Health
Full Text
Alhaj, Hussen Kutaiba. "Developmental architecture of human lymphopoiesis". Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC308.
Texto completo da fonteThe standard model of hematopoiesis proposes that hematopoietic differentiation is a stepwise bifurcation process. The first separation downstream of hematopoietic stem cells will segregate mutipotent progenitors into common lymphoid and myeloid progenitors. In human many evidences support the idea that human hematopoietic organization doesn't follow the classical model, but the question was not concluded and need for further investigation. Due to limited access to primary bone marrow samples and lack of appropriate in vivo model human studies face many difficulties. In this work, we used a xenogeneic model of human fetal hematopoiesis in immune-deficient mice to dissect the early stages of lymphoid development. This model relies on the injection of UCB CD34+ cells into NSG mice. Flow cytometry analysis and gene expression profiling of humanized mice BM populations revealed that this model faithfully reproduces human fetal hematopoiesis. Combining in vitro differentiation assays to molecular studies and genetic approaches, we show that fetal human lymphopoiesis displays a dual organization, split into an ancestral CD127+ CLP-like population devoid o myeloid potential that differentiate preferentially into follicular B cells and ILC3s, and into a previously undescribed CD127- population mainly dedicated to the generation of T, marginal zone B, NK, and ILC1s We also provide evidence that Early Lymphoid Progenitors emerge independently from multipotent developmental intermediates referred to as lympho-mono'dendritic progenitors. These results confirm that human hematopoiesis doesn't follow the standard model of hematopoietic differentiation established in the mouse
Gonzalez, Laurie Jackson. "The Influence of Membrane Lipid Order on Cell Shape and Microvesiculation in Human Erythrocytes". BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/1058.
Texto completo da fonteMason, Nena Lundgreen. "The Anatomy of Porcine and Human Larynges: Structural Analysis and High Resolution Magnetic Resonance Imaging of the Recurrent Laryngeal Nerve". BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5783.
Texto completo da fonteHubbell, Zachariah Randall. "Developmental Mechanobiology of the Metaphyseal Cortical-Trabecular Interface in the Human Proximal Tibia and Proximal Humerus". The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1452264587.
Texto completo da fonteSpaw, Alexandra J. "Fetal Developmental Anatomy of the Human Cardiovascular and Central Nervous Systems Using Lugol’s Iodine Staining and Micro-Computed Tomography". Ohio University Honors Tutorial College / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1398950897.
Texto completo da fonteBeck, Cameron McKell. "Construction of a COL11A1 Transgene Vector". Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1545.pdf.
Texto completo da fonteAhmad, Faizzan Syed. "A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype". Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:17972018-6750-4e5c-8cc9-42e9c381f531.
Texto completo da fontePoier, Paloma Hohmann. "Avaliação da oscilação corporal e marcha de idosos com a utilização de um andador com suporte de tronco desenvolvido na UTFPR". Universidade Tecnológica Federal do Paraná, 2013. http://repositorio.utfpr.edu.br/jspui/handle/1/744.
Texto completo da fonteIntroduction: Postural instability is one of the causes of disability in the elderly and the use of walkers is one of the strategies to generate greater stability and safety in the maintenance of orthostatic posture and gait. There are currently walkers considered to be specials because they have braces and support systems or offer partial support of the body. Despite the benefits of using these walkers, they are very expensive. In order to present an alternative of quality and low cost, a walker with trunk support was developed, made of PVC. The trunk support attached to the walker is intended to support the weight of the user in the event of a fall. Objective: To evaluate the influence of the use of the walker with trunk support on body sway and gait of the elderly with postural instability. Method: Tests were carried out to analyze the mechanical resistance of the material used as well as the structure of the walker. PVC has proven to be a material with high resistance when submitted to flexion and impact tests. The maximum mass supported by the walker in the test was approximately 226 kg. After testing the equipment, 9 elderly with postural instability were submitted to evaluation of the body sway or stabilometry, and 3 elderly to gait analysis, with and without the use of the walker developed. Results: Using the walker there was a decrease of body sway in all elderly participants. Without the use of the equipment the stabilometry average value was 10,297 cm² and when using the walker it was 3.264 cm². In the evaluation of gait analysis with accelerometer sensors located at the hip joint, without the walker the elderly had greater hip extension and lower hip flexion and, with the walker the results had inverted values. For that, the average flexion on the right hip rose from 15.33° to 20.67° and the extension decreased from 10° to 7.33°. The time needed to finish a course of 12 meters was higher using the walker. The results point to an improvement in stability and balance for the elderly using the walker. The gait analysis demonstrated a reorganization of the length of the stride but without a significant change.
Huyard, Fanny. "Impact du stress hyperoxique en période néonatale sur la structure vasculaire : implication des phénomènes de sénescence et rôle possible dans la programmation développementale de l'hypertension artérielle". Thèse, Université de Lorraine, 2013. http://hdl.handle.net/1866/12773.
Texto completo da fonteCe projet traite de la programmation développementale de l’hypertension artérielle (HTA) à travers des influences néonatales précoces pouvant moduler le développement vasculaire. Les bébés prématurés présentent des défenses antioxydantes diminuées comparés aux nouveau-nés à terme et sont exposés à la naissance à des concentrations élevées en oxygène (O2) engendrant la production d’espèces réactives de l’O2 (ERO). Les conséquences vasculaires à long terme de dommages liés aux ERO en période néonatale et les mécanismes impliqués sont très partiellement compris. Les précédents résultats du laboratoire ont montré qu’un stress hyperoxique néonatal conduit chez le rat adulte à de l’HTA, une dysfonction endothéliale et une rigidité artérielle, éléments de vieillissement vasculaire. Nous émettons l'hypothèse qu'un stress hyperoxique néonatale conduit à long terme à l'altération de la structure vasculaire et à un vieillissement vasculaire précoce. Nous avons démontré une diminution de la prolifération cellulaire, une capacité angiogénique altérée, des dommages à l’ADN et une augmentation de l’expression de protéines de sénescences (des indices de sénescence cellulaire) au-delà de la période néonatale suite à une exposition brève à l’O2 au niveau vasculaire dans un modèle animal (ratons Sprague-Dawley exposés à 80 % d’O2 du 3ème au 10ème jour de vie comparés à des ratons restés à l’air ambiant) et cellulaire (cellules musculaires lisses d'aortes thoraciques d'embryon de rat exposées à 40% O2 pendant 24h ou 48h, puis remises en normoxie pendant 96h). De plus, des altérations des composants de la structure vasculaire indiquant un remodelage vasculaire aortique ont été mises en évidence. Ces changements précèdent tous l’HTA et la dysfonction vasculaire observées dans le modèle animal à l’âge adulte et pourraient y contribuer. L’étude de jeunes adultes nés < 29 semaines comparés à des jeunes adultes nés à terme indique une augmentation de marqueurs de rigidité artérielle (indices d’un vieillissement vasculaire précoce) chez la population prématurée. L’ensemble des résultats démontre un vieillissement vasculaire précoce après une exposition néonatale transitoire à un stress hyperoxique permettant une meilleure compréhension des mécanismes physiopathologiques impliqués dans la survenue des troubles vasculaires retrouvés chez l’adulte et contribue à la mise en place de moyens de prévention chez des patients prématurés.
The scope of this thesis is developmental programming of arterial high blood pressure (HBP) hypertension through early neonatal stimuli that may alter vascular development. Premature newborns have decreased antioxidant defenses compared to term babies and are exposed upon birth to high oxygen (O2) concentration, causing reactive oxygen species (ROS) production. Long term vascular consequences of ROS related damage during the neonatal period and the mechanisms involved remain unknown. Recent data from the laboratory show that neonatal hyperoxic stress leads in adult rat to HBP, endothelial dysfunction and arterial rigidity, characteristic features of vascular aging. We hypothesize that a neonatal hyperoxic stress leads to long term vascular structure alteration explained by an early aging of the vascular system. We showed a decreased proliferation rate, an altered angiogenic capacity, as well as long term DNA damage and increased expression of senescence proteins at a vascular level following O2 exposure in the animal (male Sprague-Dawley pups kept at 80% O2 from postnatal days 3 to 10 vs. rats remained in room air) and cellular models (embryonic vascular smooth muscle cells from rat thoracic aorta exposed to 40% O2 for 24h or 48h followed by 96h recovery in control conditions). In addition, alterations of vascular structure components indicating vascular remodeling was shown before the onset of the HBP at adult age. Those changes precede the HBP and vascular dysfunction observed in our animal model at adult age and could contribute to them. Study of young adults born before 29 weeks vs. young adults born at term showed that young adults born preterm present indices of arterial stiffness vs. term controls. Results of the present thesis demonstrate a major role of premature vascular aging in the surge of vascular diseases in adulthood and contribute to a better understanding of the patho-physiological mechanisms involved and could put into practice new prevention strategies among preterm patients.
Goel, Vritti R. "A Proposal to Test the Effects of Factor ECAT1 on Pluripotency, from Reprogramming to Differentiation of Human Somatic Cells". Scholarship @ Claremont, 2012. http://scholarship.claremont.edu/cmc_theses/470.
Texto completo da fonteMartel, Marie. "Body representations in action : development and plasticity in the sensory guidance of prehension". Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1288.
Texto completo da fonteTo prepare and perform movements efficiently, accurate action representations are necessary, formalized by computational science as “internal models”. Actions representations do not require exclusively the representation of object properties, information about the body and particularly the effector such as its posture and dimension are also crucial. Thus, effector representations need to be updated to account for postural changes, yet, they do not play a prominent role in the actual models of motor control. In addition, updates settings of both action and body representation are presumably established ontogenetically, but little is known on their developmental path. First, I investigated the maturation of action representation in children from 5 to 10 years of age, as well as the potential differences in children with Developmental Coordination Disorder (DCD). Through kinematics analyses, I sought to understand how children develop their ability to control their movements. Second, using a tool functionally extending arm length, I questioned the sensory inputs for body representation plasticity in adults, such as proprioception and vision. Third, I probed rapid body representations plasticity during the slowly changing dimensions of the body during growth. To this aim I investigated in typically developing children and adolescents tool-induced plasticity of the upper-limb representation. Finally, I discuss the relationship between body representations and motor control in adults and children, as despite being both related they have often times walked parallel ways
Puard, Vincent. "Marqueurs non-invasifs de la compétence ovocytaire au développement dans les cellules de cumulus chez l'humain". Thesis, Tours, 2013. http://www.theses.fr/2013TOUR3310/document.
Texto completo da fonteThe ability to predict the developmental and implantation ability of embryos remains a major goal in human assisted reproductive technology (ART).ART should allow couple to become parents while limiting the risks to the mother and the child in case of multiple pregnancy. ART laboratories use morphological criteria to evaluate the oocyte competence despite the poor predictive value of this analysis. The oocyte-cumulus interaction helps the oocyte to acquire its developmental competence partly through the expression of specific genes at the cumulus level. Therefore our aim was to identify at the level of cumulus cells (CCs) genes and proteins related to oocyte developmental competence as non-invasive marker. Gene expression of CCs was studied using microarray and high throughput qPCR according to the developmental competence of the oocyte (ability to reach the blastocyst stage after fertilization). While taking into account the patient variability we identified RGS2, POLR3K and CUL4B as biomarkers at RNA level. Then protein expression of CCs was studied using Reverse Phase Protein Array. After validation of the antibodies targeting the proteins of interests, RGS2, POLR3K and MERTK were identified as protein biomarkers of the developmental competence of the oocyte. These results lead us to consider a multi variables predictive model including the morphology of the embryo at J2, genes and protein markers
Osama, Mohammad. "Function of Vascular Endothelial Cells in Aging and Hypothermia: Clinical Implications". Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534939514503588.
Texto completo da fonteLe, Bourgot Cindy. "La supplémentation périnatale en fibres prébiotiques (fructo-oligosaccharides à courte chaîne, scFOS) modifie le microbiote intestinal et programme le phénotype métabolique et immunitaire du porc, pris comme modèle de l’Homme". Thesis, Rennes, Agrocampus Ouest, 2016. http://www.theses.fr/2016NSARB285/document.
Texto completo da fontePerinatal scFOS supplementation modifies metabolic response to an unbalanced diet in adults by stimulating intestinal endocrine function and pancreas sensitivity to glucose, by reducing risks of inflammation, and in fine by changing metabolic homeostasis in association with modifications of microbiota.In summary, prebiotic consumption during perinatal life programs the immune and metabolic phenotype of adults through persistent modulations of intestinal microbiota. The integrated approach of data enables us to identify molecular actors involved in the differential adaptation of individuals to an unbalanced diet according to their perinatal nutrition
Gosling, Cameron McRae. "Development of an incremental step test that accounts for lower limb length for people undergoing rehabilitation". Thesis, 1996. https://vuir.vu.edu.au/17883/.
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