Teses / dissertações sobre o tema "Horace K"

The diploma thesis introduces critically selected theoretical concepts that try to describe characteristics of children's and youth literature (further: LPDM). It focuses on approx. last thirty years of foreign research in LPDM. Firstly, the attention is paid to theories analyzing LPDM for specific qualities of appropriate texts. Then, the thesis presents theories which primarily describe LPDM on the base of specific context: the context in which the works emerged and are (expertly and non-expertly) received. Finally, the diploma thesis concerns with the potential benefit of presented theories but also with their problematic parts. By that it tries to offer new tools of productive analysis and interpretation of LPDM to Czech discourse of literary science.

This thesis presents my personal view of the art and the world around us. Primary issue is the understanding of life and art as a journey and an infinite search. Based on this perspective, the specific topics like art, forms and means of expression, symbolism, concept of a journey, time and work of different artists are being surveyed both generally and specifically. Through the survey of those topics, connections and coherences are being found. This thesis also consists of an analysis of my own art work (painting) and my didactic praxis together with a subject of didactics. The elements of contemplation penetrate the entire thesis.

The thesis departs from the undetermined relation between René Daumal's unfinished novel Mount Analogue: A Novel of Symbolically Authentic Non-Euclidean Adventures in Mountain Climbing (1952) and its alleged adaptation, Alejandro Jodorowsky's 1973 film The Holy Mountain. The thesis discusses the two works from the perspective of Lacanian psychoanalysis, specifically, through the lens of the so-called Borromean knot that represents the three functions of the psyche: the Real, the Symbolic, and the Imaginary. The structure of the thesis supposes the following: the first chapter concentrates on the relevant terminology and aims to define such concepts as language and ideology for the purposes of the present thesis; the second chapter discusses the method of analysis that will be applied to Daumal's Mount Analogue and Jodorowsky's The Holy Mountain, namely, it explores the possibilities of psychoanalysis and considers the 'unscientific' approach of pataphysics that favours the particular over the general; through the concept of the sinthome the aspect of action is emphasized in the analysis of Mount Analogue, while the fourth chapter analyses The Holy Mountain from the perspective of the 'hypertrophied' Symbolic and simultaneously stresses the importance of the element of balance in the film; the final chapter,...

Anotation: In this graduation these sis processed theoretical principle of subject horse and his breeding, analisis RVP and textbook for nature study and science use relationship betwen subjects and analysis of realization some of the schemes in practises.

The volume deals with the analysis of the relationship of the two dominant theoretical approaches of European integration - supranational and intergovernmental - towards the EU enlargement policy on the example of the accession process of Montenegro. The research goes into depth by analysing not the complex accession process as such, but the relations and attention of various European institutions and the EU member states to the particular and deliberately selected negotiation chapters of the Acquis Communautaire. The main aim of the thesis is to find out to what extent and whether at all does the behaviour of the EU institutions and its member states by the accession process correspond with the internal structure of the EU policies and competences stipulated in the EU treaties. The thesis succeeded to show that there is no reason to believe that the activities of the supranational institutions of the EU - the Commission and the Parliament - are dominant by chapter which is closely connected to the exclusive competence of the EU or that they would pay any special attention to this chapter. Similarly, there is no explicit proof that the activities of the incumbent EU member states are dominant by chapter which is closely connected to the shared competence of the EU or that they would pay any...

K. I. Dientzenhofer in the service of Society of Jesus Abstract The Diploma Thesis aims to map the famous Jesuit religious buildings arising in the Czech kingdom by the hands of Kilian Ignac Dientzenhofer, as well as some smaller foundations or now-defunct constructions. Firstly it is the rural residences in Liběšice and the completion of the construction in Tuchoměřice or the dispensary in Smíchov, which has been demolished in 1930. Furthermore, the Holy Mountain Steps, which were only partially implemented according to the Dientzenhofer proposal. The Thesis also includes constructions where the architect's authorship is not proven, such as the Chapel of Sts. Archangel Michael in Kozinec and Chapel of Sts. Cross in Středokluky. An important part is also the effort to put these buildings into the context of the work of the younger Dientzenhofer and to get a closer look at the perception of their clients, including the typology of the architectural order within the function. Keywords The Church of St. Francis Xavier, the Church of St. Clement, the Church of St. Nicholas, the Church of St. Bartholomew, Prague, Opařany, Odolena Voda, Lesser Town, Tuchoměřice, Liběšice, radical Baroque, K. I. Dientzenhofer, Jesuits, architecture, rural residences, chapel

Desde que foi introduzido pelo legislador um regime de banco de horas, a doutrina e jurisprudência têm discutido inúmeras questões de grande relevância prática, tendo o leque dessas questões sido amplificado em 2019, aquando da aprovação de um regime de banco de horas instituído por referendo. Através da presente dissertação de mestrado, pretendemos analisar algumas das questões já colocadas e procurar soluções para os novos problemas determinados pelas recentes alterações legislativas, nunca perdendo de vista que, pese embora este mecanismo de flexibilização dos tempos de trabalho vise, essencialmente, a prossecução dos interesses de gestão do empregador, também os do trabalhador devem ser acautelados. Adicionalmente, para uma melhor compressão do regime atualmente em vigor, tentar-se-á percorrer, sinteticamente, a evolução do banco de horas em Portugal e comparar este regime com outros similares, vigentes noutros ordenamentos jurídicos. Deste modo, o objetivo essencial deste trabalho corresponde a uma análise do banco de horas, enquanto mecanismo singular de flexibilização dos tempos de trabalho.
Since a bank of hour’s regime was introduced by the legislator, the doctrine and jurisprudence have been debating innumerous questions of great practical relevance, having those questions been increased since 2019, when a bank of hours by referendum was implemented. In the current dissertation, we intend to analyze some of the questions that have already been debated and find solutions for the new problems determined by the recent legislative changes, never losing sight that, even though this mechanism of time flexibility prosecutes, mainly, the employer’s interests, the employee’s must also be taken into account. Additionally, in order to better understand this regime, we will try to go through its evolution in Portugal and compare it with other instruments that are similar, in other legal orders. In this way, the main goal of this thesis is to analyze the bank of hours, as a singular mechanism of time flexibility.

La dégradation protéolytique du collagène de type II est considérée comme étant un facteur majeur dans le processus irréversible de dégradation de la matrice cartilagineuse lors d’ostéoarthrose. Outre les collagénases de la famille des métaloprotéinases de la matrice (MMP-1, -8, -13), la cathepsine K est parmi les seules enzymes susceptibles de dégrader la triple hélice intacte du collagène de type II, devenant ainsi un élément pertinent pour les recherches sur l’ostéoarthrose. L’objectif à court terme de notre étude consiste en l’identification et la caractérisation de sites de clivage spécifiques de la cathepsine K sur le collagène de type II équin. La technique d’électrophorèse SDS-PAGE 1D permet la visualisation des produits de digestion et la validation des résultats de la caractérisation moléculaire des fragments protéolytiques. La caractérisation est réalisée en combinant la digestion trypsique précédant l’analyse HPLC-ESI/MS. Les résultats ont permis d’établir les sites, présents sur la carte peptidique de la molécule de collagène de type II équin, des 48 résidus prolines (P) et 5 résidus lysines (K) supportant une modification post-traductionnelle. De plus, 6 fragments majeurs, différents de ceux produits par les MMPs, sont observés par SDS-PAGE 1D puis confirmés par HPLC-ESI/MS, correspondant aux sites suivants : F1 [G189-K190], F2 [G252-P253], F3 [P326-G327], F4 [P428-G429], F5 [P563-G564] et F6 [P824-G825]. Le fragment F1 nouvellement identifié suggère un site de clivage différent de l’étude antérieure sur le collagène de type II bovin et humain. L’objectif à long terme serait le développement d’anticorps spécifiques au site identifié, permettant de suivre l’activité protéolytique de la cathepsine K par immunohistochimie et ÉLISA, dans le cadre du diagnostic de l’ostéoarthrose.
The proteolytic degradation of type II collagen is believed to be mainly an irreversible event in the process of cartilage matrix degradation in osteoarthritis. Cathepsin K is the most active enzyme protease outside the matrix metalloproteinase (MMP) family (MMP 13, -8, -1) capable of degrading the intact triple helical type II collagen. The short term objective of our study was to characterize the specific cleavage sites of CK on type II collagen. Our long term goal is to develop antibodies specific to these sites to develop biomarkers to detect it’s cleavage, for the early diagnosis of OA. Thus, in order to achieve our first goal, Cathepsin K cleavage of equine type II collagen was first examined by SDS-PAGE electrophoresis. Molecular characterization of proteolytic fragments, and therefore cleavage sites, was performed using tryptic digestion followed by LC-ESI/MS analysis to establish a comprehensive peptide map which was used as a template to identify specific proteolytic cleavage by cathepsin K. Comprehensive peptide mapping provided information on post-translational modifications and permitted the identification of 48 proline (P) and 5 lysine (K) residues that were subject to post translational modification. Six major fragments were observed on 1D SDS-PAGE and confirmed by HPLC-ESI/MS including F1 [189-190], F2 [252-253], F3 [326-327], F4 [428-429], F5 [563-564] and F6 [824-825]. The observed F1 fragment showed that cleavage was three residues N-terminal to the site reported previously for bovine type II collagen. These new findings will be used to develop new analytical methods to quantify biomarkers associate to equine type II collagen degradation in osteoarthritis patient and/or to support the development of new treatments.

This thesis focuses on the manuscript entitled The Violin and the Horse, and pursues two approaches: one is based on the Romani studies, the other on the methods of the history science. Its aim is to verify historical facts contained in the manuscript. The main presumption of the thesis is the attribution of the text to Rudolf Daniel - the thesis verifies autobiographical data and its cultural and social context. The paper systematically concentrates on the figure of Rudolf Daniel (born 1911 in Oslavany - died in 1978 in Brno) and his biography (entirely unknown so far). The context of the manuscript The Violin and the Horse is framed by the post-war Roma ethno-emancipatory movement, and Rudolf Daniel is a newly discovered figure of its history. Keywords: the Roma, horse trade, the Holocaust, ethno-emancipatory movement, history of the Roma

The purpose of this thesis is to elaborate the inventory of Jewish possessions in the town district of Sedlcany which would provide an answer to the economic and social status of this persecuted minority. The primary sources are the record-keeping cards from the Jewish card files, the registration of the Jewish landed estate in the town district of Sedlcany, the police entries, as well as, the population census from 1930. The acquired information about the Jewish possessions relates to the year 1940 too, therefore, this thesis is also focused on the period of the Protectorate of Bohemia and Moravia. The first chapter briefly engages the reader with the history of the Jews in Bohemia with a specific focus of the town district of Sedlcany. The key part of this work is the detailed outline of the encoroachment on the economic life of the Jews not only in the Third Reich, but also on which ?the Aryan race? received their possessions. The key part of this thesis is a list of the Jewish population living in the town district of Sedlcany and nearby villages before deportations, an overview of family ties, and also an overview of movable and inmovable assets of individuals. Another essential charter of this work is the restituion of thirteen survivers that emphasises the response of the country and individuals to the return of the Jews after the Second World Ward and the progress of the administrative process. At last, this thesis offers charts, tables, maps with highlighted municipalities where the Jews had lived, and also three maps illustrating the Jewish settlement in the town district of Sedlcany, and the municipalities of Kosova Hora and Petrovice. It further illustrates a family tree of the Lurie family from Petrovice, an inventory list of goods from Lurie?s shop in Petrovice and, last but no least, photos of some Jews living in the district of Sedlcany in 1940.

TITLE: Natural communication with the horse and the possibilities of human - horse interaction AUTHOR: Bc. Lenka Volfová DEPARTMENT: Department of Biology and Enviromnental Studies (Katedra biologie a enviromnentálních studií) SUPERVISOR: PhDr. Kateřina Jančaříková, Ph.D. ABSTRACT: This thesis explores interspecies communication and, specifically, natural communication between the man and the horse. Through comparative research based on a programme developed by Ing. Josef Liška (Liška Solutions) for the assessment of the participant's personality, employing several exercises with a horse from the ground, the thesis aims at introducing ways in which horses can be used for the purposes of personal growth. For the purposes of this thesis, volunteers from three groups were assessed under this programme using the method of direct observation: teachers, business executives and people who work with animals. The assessment was carried out by marking down points and comments. On the basis of the results obtained, the above three groups were subsequently compared among one another. The research shows that teachers excelled in six out of seven observed personal competencies while, compared to business executives, there is still space for improvement in terms of their energy. The results shown in relation to the...

Les ostéoclastes, les seules cellules capables de résorber l’os, sont soupçonnés d’être associés au développement et à la progression des radiotransparences sous-chondrales (SR). Ils n’ont par contre jamais été étudiés in situ. Les objectifs de cette étude cadavérique ex vivo étaient de mesurer et de comparer la densité ostéoclastique et le pourcentage de chondroclastes se trouvant à différentes profondeurs de l’os sous-chondral à partir de la surface articulaire dans le condyle fémoral médial (CFM) de chevaux Pur-sang juvéniles sains et atteints de SR hâtives spontanées. Les spécimens provenaient d’une banque de tissus et faisaient partie d’une étude précédente sur les caractéristiques structurelles des SR. La tomodensitométrie identifiait les CFM atteints de SR (n=6) et guidait les coupes ostéochondrales. Les contrôles de l’étude étaient composés d’un site histologiquement normal et caudal à la lésion (n=6) et du site controlatéral à la lésion dans le CFM sain (n=5). Après la décalcification et la fixation dans la paraffine, les spécimens étaient colorés à l’immunohistochimie afin de mettre en évidence les ostéoclastes présents dans l’os en périphérie des SR. Les spécimens étaient ensuite séparés en régions d’intérêt (ROI) à différentes profondeurs de l’os sous-chondral: ROI1 (0-1mm), ROI2 (1-3mm) et ROI3 (3-6mm). Les ostéoclastes ont été comptés dans chaque ROI pour calculer leur densité ostéoclastique respective. Les lames ont été contre-colorées avec la Safranine afin d’identifier le cartilage et mesurer le pourcentage de chondroclastes. La densité ostéoclastique était statistiquement plus élevée dans la ROI1 comparativement à la ROI3 dans tous les groupes. Cependant, aucune différence significative n’a été détectée en comparant les ROI entre les groupes, même si la densité ostéoclastique était supérieure dans la ROI1 des SR. Malgré une proportion de chondroclastes dans la ROI1 des SR inférieure à celle des contrôles, aucune différence significative n’a été détectée. La limite principale de cette étude se révéla être la taille de l’échantillon. Nos résultats démontrent cependant que la pathophysiologie des SR n’est pas uniquement expliquée par l’augmentation du nombre d’ostéoclastes dans l’os sous-chondral en périphérie des lésions.
There is a knowledge gap concerning how and when equine medial femoral condyle (MFC) subchondral radiolucencies (SR) arise and evolve. Osteoclasts, the only cells capable of bone resorption, are believed to have a role, but have not been studied in situ. The objectives of this ex vivo cadaveric study were to measure and compare the osteoclast density and the percentage of chondroclasts in juvenile (<1 year) Thoroughbred MFCs at varying depths from the weightbearing articular surface in both healthy and early spontaneous MFC SR specimens. The MFCs were available in a tissue bank and were part of a prior study of the structural characteristics of SRs. Computed tomography permitted identification of MFC SR (n=6) and guided osteochondral slab sections. Controls included a histologically normal site caudal to the lesions (n=6) and the healthy contralateral MFC lesion site (n=5). Following decalcification, paraffin embedding sections were cut and stained immunohistochemically with Cathepsin K to permit osteoclast identification and counting. The sections were divided into regions of interest (ROI) at different depths in the subchondral bone from the osteochondral junction: ROI1 (0-1mm), ROI2 (1-3mm) and ROI3 (3-6mm). Osteoclasts were counted in each ROI in order to calculate an osteoclast density. A Safranin-O counterstain was performed to identify the cartilage and measure the chondroclasts percentage. Osteoclast density was significantly higher in ROI1 when compared with ROI3 in all groups. When ROIs were compared between the three groups, no statistically significant differences were detected, even if a visible pattern difference and higher osteoclast density values were recorded in ROI1 in SRs. However, although the proportion of chondroclasts in ROI1 was lower in the SR sections when compared with controls, no significant difference was detected. The main limitation was the limited sample size. Osteoclasts are important actors in MFC subchondral bone development, digesting both growth cartilage (chondroclasts) and bone, but the pathophysiology of early MFC SRs cannot be explained solely by an increased osteoclast presence in the peripheral subchondral bone.