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1

Maddigan, Meaghan E., Kathleen M. Sullivan, Israel Halperin, Fabien A. Basset, and David G. Behm. "High tempo music prolongs high intensity exercise." PeerJ 6 (January 8, 2019): e6164. http://dx.doi.org/10.7717/peerj.6164.

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Music has been shown to reduce rating of perceived exertion, increase exercise enjoyment and enhance exercise performance, mainly in low-moderate intensity exercises. However, the effects of music are less conclusive with high-intensity activities. The purpose of this with-participant design study was to compare the effects of high tempo music (130 bpm) to a no-music condition during repeated high intensity cycling bouts (80% of peak power output (PPO)) on the following measures: time to exercise end-point, rating of perceived exertion (RPE), heart rate (HR), breathing frequency, ventilatory kinetics and blood lactate (BL). Under the music condition, participants exercised 10.7% longer (p = 0.035; Effect size (ES) = 0.28) (increase of 1 min) and had higher HR (4%; p = 0.043; ES = 0.25), breathing frequency (11.6%; p < 0.001; ES = 0.57), and RER (7% at TTF; p = 0.021; ES = 1.1) during exercise, as measured at the exercise end-point. Trivial differences were observed between conditions in RPE and other ventilatory kinetics during exercise. Interestingly, 5 min post-exercise termination, HR recovery was 13.0% faster following the music condition (p < 0.05) despite that music was not played during this period. These results strengthen the notion that music can alter the association between central motor drive, central cardiovascular command and perceived exertion, and contribute to prolonged exercise durations at higher intensities along with a quicken HR recovery.
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Mustafa Khan, Ghulam, Daniya Khan, Iram Saddiqa Aamir, Saher Ramees, Sassi Kanwal, Fatima Abid, and Hina Moazzam. "HIGH INTENSITY EXERCISE;." Professional Medical Journal 24, no. 03 (March 7, 2017): 414–21. http://dx.doi.org/10.29309/tpmj/2017.24.03.1562.

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Objectives: To clarify the interrelationship of high intensity exercise and durationof time on lipid profile, blood pressure and, body weight in young hyperlipidemic adults andto evaluate the beneficial effects on health in possible shorter duration of time. Study Design:Case control study. Setting: Department of Physiology, BMSI, JPMC, Karachi. Period: January2012 to April 2012. Methods: Total numbers of 60 volunteers moderately active, younghyperlipidemic adults, aged 30 to 50 years, thirty for each A (control), and B (high intensityexercise) group respectively were assigned to participate for 12 weeks exercise programwithout restricted caloric diet at pre–identified track of specific time. Lipids profile and age, sex,weight, BMI, blood pressure, and lab investigations like serum Total cholesterol, Triglycerides,LDL, and HDL, of each participant were recorded at baseline (0 day) and similarly on day30, 60 and 90 respectively. Results: At the end of the 12 weeks program in high intensityexercise group significant effects have been observed by lowering the level of total cholesterol,triglyceride (p <0.05) and lipoproteins variables, with increasing the level of HDL-c. While nosignificant change in blood pressure and weight reduction was observed between indicialand final measurement in control and high intensity exercise groups (p<o.o5). Conclusion:Finding of this study suggest that, high intensity exercise has positive effects on lipid profileby lowering the level of total cholesterol(TC), triglycerides(TGs) low density lipoprotein (LDL-c)and increasing the level of high density lipoprotein (HDL-c) in hyperlipidemic adults rapidlyin short duration of time, thus have beneficial effects by reducing the cardiac risk factors,chronic metabolic disorders and improving the cardio respiratory fitness but reduction in bloodpressure body weight can be achieved in short time by combination of high intensity exerciseand nutritional guidance of caloric restriction.
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Sara Campos Vaz, Luna, Márcia Reimol De Andrade, and Laila Cristina Moreira Damázio. "Morphological aspects of the heart of young rats subjected to high and medium intensity progressive resistance physical exercise protocols." Concilium 24, no. 9 (May 14, 2024): 577–87. http://dx.doi.org/10.53660/clm-3419-24i33.

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The present study investigated the effects of medium and high intensity physical exercise on the morphology of the heart of young rats, after carrying out two physical exercise protocols on the stairs, medium and high intensity. We used 24 young male Wistar rats, 21 days old, divided into three groups: sedentary control group (CG, n=8), group trained with medium intensity physical exercises (GM, n=8) and group trained with physical exercises high intensity (GA, n=8). For 4 weeks, the animals in the GM and GA groups were subjected to a medium and high intensity physical exercise protocol. The physical exercise protocol was applied over a period of 4 weeks, 5 days a week. After training, the animals were euthanized and the heart was removed for weighing, analysis of macroscopic morphology (left ventricular thickness, weight, analysis of diameter and ventricular area); The 5um sections were then processed and stained with Hematoxylin and Eosin (HE) for subsequent histomorphometric analysis of the cardiomyocytes. The results did not demonstrate significant differences in the macroscopic parameters of the heart (weight, left ventricular thickness, ventricular area, total area, ventricular diameter). A significant difference was observed in the area of cardiomyocytes in the left ventricle of rats that exercised with high intensity. It is concluded that rats exercising at high intensity showed an increase in the area of cardiomyocytes compared to rats that exercised at medium intensity and sedentary ones. Thus, it is concluded that progressive resistance physical exercise on the vertical ladder when performed at high intensity promotes cardiomyocyte hypertrophy in young rats.
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Pettitt, Robert W., and Ida E. Clark. "High-Intensity Exercise Tolerance." Strength and Conditioning Journal 35, no. 2 (April 2013): 11–16. http://dx.doi.org/10.1519/ssc.0b013e31828a9520.

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Cooper, Simon B., Karah J. Dring, and Mary E. Nevill. "High-Intensity Intermittent Exercise." Current Sports Medicine Reports 15, no. 4 (2016): 245–51. http://dx.doi.org/10.1249/jsr.0000000000000273.

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Yu, Ming, Xinyi Han, Xiaomei Wang, and Rongxin Guan. "Effects of Physical Exercise on Executive Functions among College Students in China: Exploring the Influence of Exercise Intensity and Duration." Behavioral Sciences 13, no. 12 (November 29, 2023): 987. http://dx.doi.org/10.3390/bs13120987.

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Background: This study investigates the effects of exercise intensity and duration on executive functions among college students in China. Method: Participants in this study were Chinese college students divided into four groups based on exercise duration and intensity. Each group engaged in physical exercise twice a week for six weeks. Group 1 performed low-intensity exercises for 10 min per session; Group 2 performed low-intensity exercises for 20 min per session; Group 3 performed high-intensity exercises for 10 min per session; and Group 4 performed high-intensity exercise for 20 min per session. Executive functions were assessed in all subjects before the experiment (time 1), after one exercise session (time 2), at the end of the exercise program (time 3), and six weeks after the exercise program (time 4). A mixed ANOVA with a 2 (exercise intensity: low/high) × 2 (duration: short/long) × 4 (time of measurement: time 1/time 2/time 3/time 4) design was employed, with exercise intensity and exercise duration as independent variables and executive functions as the dependent variable. Results: Mixed ANOVA showed that the results revealed a significant main effect of measurement time on working memory accuracy (p < 0.001) and reaction time (p < 0.001); inhibition control accuracy (p < 0.001) and reaction time (p < 0.001); cognitive flexibility accuracy (p < 0.001) and reaction time (p < 0.001). A single session of high-intensity exercise significantly improved executive functions in college students. Both low-intensity and high-intensity exercise were effective in enhancing executive functions, with high-intensity exercise demonstrating better maintenance of the effect. Conclusion: Both exercise intensity and exercise duration were found to enhance executive functions in college students, with exercise intensity showing greater effectiveness than exercise duration.
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Roemmich, James, Kelsey Ufholz, Kyle Flack, Tori Kaster, and William Siders. "High Intensity Interval Training to Increase Tolerance for Exercise Intensity." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 1763. http://dx.doi.org/10.1093/cdn/nzaa066_018.

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Abstract Objectives Increasing the reinforcing value of a stimulus occurs after repeated exposures to the reinforcer via neuroadaptations that increase the incentive salience of the stimulus. Exercise is a reinforcer and increasing exercise reinforcement (RRVex) may be dependent on simultaneously increasing tolerance for exercise intensity. Positive outcome expectancy (POE) of participating in an intervention can be an important determinant of treatment efficacy, such as when attempting to increase tolerance for exercise intensity or RRVex. We hypothesized that (1) high-intensity interval training (HIIT) that produces great discomfort would increase tolerance for exercise intensity, (2) adding a positive outcome expectancy (POE) component to HIIT would further increase tolerance for exercise intensity and, (3) increases in tolerance for exercise discomfort would mediate increases in RRVex. Methods A randomized controlled trial with a factorial design included HIIT + POE (n = 33 adults, n = 19 women) and HIIT-only (n = 33, n = 19 women) groups. Both groups participated in HIIT 3 d/wk for 6 wks. HIIT + POE received POE treatment each exercise session. Outcomes were measured at baseline, after 6 weeks of HIIT, and 4 weeks post-HIIT (10 wk). Changes in the RRVex were assessed by a progressive ratio schedule of reinforcement task. Other outcomes were outcome expectations, tolerance for exercise intensity, and behavior regulations of exercise. Results Outcome expectancy did not change in either group. Tolerance for exercise discomfort increased (P < .001) above baseline by 12% at 6 wk and 13% at 10 wk. Intrinsic, integrated, and identified behavior regulations of exercise were all increased (P < .01) at 6 wk and remained so at 10 wk. However, RRVex was not changed and change in RRVex was not correlated with change in tolerance for exercise intensity. Conclusions HIIT increases tolerance for exercise intensity and intrinsic, integrated, and identified behavior regulations of exercise. Funding Sources USDA-ARS.
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Njapo, Steve Noutong, Brittney Heard, and Mohamed Morsy. "HIGH INTENSITY EXERCISE INDUCED STEMI." Journal of the American College of Cardiology 75, no. 11 (March 2020): 2446. http://dx.doi.org/10.1016/s0735-1097(20)33073-4.

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Goršič, Maja, Imre Cikajlo, Nika Goljar, and Domen Novak. "A Multisession Evaluation of a Collaborative Virtual Environment for Arm Rehabilitation." PRESENCE: Virtual and Augmented Reality 27, no. 3 (July 2020): 274–86. http://dx.doi.org/10.1162/pres_a_00331.

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In recent years, several multi-user virtual environments (VEs) have been developed to promote motivation and exercise intensity in motor rehabilitation. While competitive VEs have been extensively evaluated, collaborative and competitive rehabilitation VEs have seen relatively little study. Therefore, this article presents an evaluation of a VE for post-stroke arm rehabilitation that mimics everyday kitchen tasks and can be used either solo or collaboratively. Twenty subacute stroke survivors exercised with the VE for four sessions, with the first and third sessions involving solo exercise and the other two involving collaborative exercise. Exercise intensity was measured using inertial sensors while motivation was measured with questionnaires. Results showed high motivation and exercise intensity over all four sessions, and 11 of 20 participants preferred collaborative over solo exercise while only 4 preferred solo exercise. However, there were no differences in motivation, exercise duration, or exercise intensity between solo and collaborative sessions. Thus, we cannot currently claim that collaborative exercises are beneficial for upper limb rehabilitation. Future studies should evaluate other collaborative VE designs in different settings (e.g., at home) and with different participant pairs (e.g., patient-unimpaired) to find effective ways to utilize collaborative exercises in motor rehabilitation.
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Shi, Haoyu, and Young-Je Sim. "Effects of weekend-focused exercise on obesity-related hormones and metabolic syndrome markers in male high school students." Journal of Exercise Rehabilitation 20, no. 6 (December 26, 2024): 227–34. https://doi.org/10.12965/jer.2448632.316.

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To examine the changes in obesity-related hormones and metabolic syndrome markers in male high school students with obesity following a weekend-focused moderate- or high-intensity exercise program at the recommended weekly physical activity level, or a program of regular exercise 3 times a week at moderate intensity, over a 10-week period. Forty-eight male high school students who were obese with a body fat percentage of ≥ 25% were randomly assigned to one of three groups: a regular moderate-intensity exercise group (n= 17) that freely selected and performed moderate-intensity aerobic and resistance training exercises, every Monday, Wednesday, and Friday, for a total of 150–300 min/wk; a weekend-focused moderate-intensity exercise group (n= 15) that freely selected and performed aerobic and resistance training exercises every Saturday for 150–300 min; and a weekend-focused high-intensity exercise group (n= 16) that freely selected and performed aerobic and resistance training exercises every Sunday for 75–150 min. Insulin and leptin levels significantly decreased in all the groups, with the greatest reduction in the regular exercise group. Abdominal circumference and triglyceride levels significantly decreased in all the groups. Fasting glucose decreased only in the regular exercise group. High-density lipoprotein cholesterol significantly increased in both the regular and weekend-focused moderate-intensity exercise groups. No significant differences in adiponectin levels, and systolic and diastolic blood pressure were observed between the groups. A weekend-focused exercise program has health effects similar to those of regular exercise, highlighting the importance of meeting the recommended weekly physical activity levels.
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Safarinejad, Mohammad Reza, Kamran Azma, and Ali Asgar Kolahi. "The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus–pituitary–testis axis, and semen quality: a randomized controlled study." Journal of Endocrinology 200, no. 3 (December 3, 2008): 259–71. http://dx.doi.org/10.1677/joe-08-0477.

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Effects of intensive exercise on hypothalamus–pituitary–testis (HPT) axis remain controversial. Our aim was to determine the effects of intensive, long-term treadmill running on reproductive hormones, HPT axis, and semen quality. A total of 286 subjects were randomly assigned to moderate-intensity exercise (∼60% maximal oxygen uptake (VO2max); group 1, n=143) and high-intensity exercise (∼80% VO2max; group 2, n=143) groups. The two groups exercised for 60 weeks in five sessions per week, each session lasting 120 min. This was followed by a 36-week low-intensity exercise recovery period. All subjects underwent routine semen analysis. Blood samples were drawn for the determination of the levels of the following hormones: LH, FSH, prolactin, testosterone (T), free testosterone (fT), inhibin B, and sex hormone-binding globulin (SHBG). The HPT axis was assessed using GnRH and human chorionic gonadotropin tests. After 24 weeks of exercise, the subjects exercising with high intensity demonstrated significantly declined semen parameters compared with those exercising with moderate intensity (P=0.03). Serum T and fT began to decrease, and serum SHBG began to increase at the end of 12 weeks with both moderate- and high-intensity exercises. The serum LH and FSH concentrations decreased below the baseline level at 12 weeks in both groups (P=0.07 in group 1 and 0.03 in group 2). Both groups had blunted LH and FSH responses to GnRH. These parameters improved to their pre-exercise level during the recovery period. Long-term strenuous treadmill exercises (overtraining syndrome) have a deleterious effect on reproduction.
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Allen, David, and Håkan Westerblad. "What limits exercise during high-intensity aerobic exercise?" European Journal of Applied Physiology 110, no. 3 (June 15, 2010): 661–62. http://dx.doi.org/10.1007/s00421-010-1538-z.

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Gordon, Brett A., Caroline J. Taylor, Jarrod E. Church, and Stephen D. Cousins. "A Comparison of the Gluco-Regulatory Responses to High-Intensity Interval Exercise and Resistance Exercise." International Journal of Environmental Research and Public Health 18, no. 1 (January 2, 2021): 287. http://dx.doi.org/10.3390/ijerph18010287.

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High-intensity interval exercise and resistance exercise both effectively lower blood glucose; however, it is not clear whether different regulatory mechanisms exist. This randomised cross-over study compared the acute gluco-regulatory and the physiological responses of high-intensity interval exercise and resistance exercise. Sixteen (eight males and eight females) recreationally active individuals, aged (mean ± SD) 22 ± 7 years, participated with a seven-day period between interventions. The high-intensity interval exercise trial consisted of twelve, 30 s cycling intervals at 80% of peak power capacity and 90 s active recovery. The resistance exercise trial consisted of four sets of 10 repetitions for three lower-limb exercises at 80% 1-RM, matched for duration of high-intensity interval exercise. Exercise was performed after an overnight fast, with blood samples collected every 30 min, for two hours after exercise. There was a significant interaction between time and intervention for glucose (p = 0.02), which was, on average (mean ± SD), 0.7 ± 0.7 mmol∙L−1 higher following high-intensity interval exercise, as compared to resistance exercise. Cortisol concentration over time was affected by intervention (p = 0.03), with cortisol 70 ± 103 ng∙mL−1 higher (p = 0.015), on average, following high-intensity interval exercise. Resistance exercise did not induce the acute rise in glucose that was induced by high-intensity interval exercise and appears to be an appropriate alternative to positively regulate blood glucose.
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Lagally, Kristen M., Kara I. Gallagher, Robert J. Robertson, Randall Gearhart, and Fredric L. Goss. "Ratings of Perceived Exertion during Low- and High-Intensity Resistance Exercise by Young Adults." Perceptual and Motor Skills 94, no. 3 (June 2002): 723–31. http://dx.doi.org/10.2466/pms.2002.94.3.723.

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Ratings of perceived exertion (RPE) are commonly used to monitor the intensity of aerobic exercise. Whether ratings of perceived exertion can be used similarly during resistance exercise is unclear. To examine this question, perceived exertion was measured at 30% and 90% of the one-repetition maximum (1-RM), while holding work constant between intensities. Ratings for the active muscles and for the overall body were examined during both intensities. 10 male (age = 23.2 ± 3.6 yr.) and nine female (age = 21.8 ± 2.7 yr.) volunteers underwent a one-repetition maximum procedure for each of the following exercises; bench press, leg press, latissimus pull down, triceps press, biceps curl, shoulder press, and calf raise. All subjects then completed two experimental trials on separate days. The high-intensity trial consisted of one set of five repetitions at 90% of the one-repetition maximum. The low-intensity trial consisted of one set of 15 repetitions at 30% of the one-repetition maximum. Active muscle and overall body ratings of perceived exertion were obtained immediately at termination of each of the seven exercises at both intensities. A two-factor (RPE x Intensity) repeated-measures analysis of variance was performed separately for each exercise. Both active muscle and overall body ratings of perceived exertion were higher ( p<.01) for the high-intensity trial than for the low intensity trial. Active muscle ratings were higher ( p<.01) than overall body ratings for all exercises. Ratings of perceived exertion during resistance exercise are related to intensity of the resistance exercise (percentage of the one-repetition maximum). This information suggests that ratings of perceived exertion can provide information regarding the intensity of resistance exercise. Furthermore, sensations of exertion in the active muscles during resistance exercise are greater than sensations for the overall body.
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De Feo, P. "Is high-intensity exercise better than moderate-intensity exercise for weight loss?" Nutrition, Metabolism and Cardiovascular Diseases 23, no. 11 (November 2013): 1037–42. http://dx.doi.org/10.1016/j.numecd.2013.06.002.

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Behm, David G., Dario Cappa, and Geoffrey A. Power. "Trunk muscle activation during moderate- and high-intensity running." Applied Physiology, Nutrition, and Metabolism 34, no. 6 (December 2009): 1008–16. http://dx.doi.org/10.1139/h09-102.

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Time constraints are cited as a barrier to regular exercise. If particular exercises can achieve multiple training functions, the number of exercises and the time needed to achieve a training goal may be decreased. It was the objective of this study to compare the extent of trunk muscle electromyographic (EMG) activity during running and callisthenic activities. EMG activity of the external obliques, lower abdominals (LA), upper lumbar erector spinae (ULES), and lumbosacral erector spinae (LSES) was monitored while triathletes and active nonrunners ran on a treadmill for 30 min at 60% and 80% of their maximum heart rate (HR) reserve, as well as during 30 repetitions of a partial curl-up and 3 min of a modified Biering-Sørensen back extension exercise. The mean root mean square (RMS) amplitude of the EMG signal was monitored over 10-s periods with measures normalized to a maximum voluntary contraction rotating curl-up (external obliques), hollowing exercise (LA), or back extension (ULES and LSES). A main effect for group was that triathletes had greater overall activation of the external obliques (p < 0.05), LA (p = 0.01), and LSES (p < 0.05) than did nonrunners. Main effects for exercise type showed that the external obliques had less EMG activity during 60% and 80% runs, respectively, than with the curl-ups (p = 0.001). The back extension exercise provided less ULES (p = 0.009) and LSES (p = 0.0001) EMG activity than the 60% and 80% runs, respectively. In conclusion, triathletes had greater trunk activation than nonrunners did while running, which could have contributed to their better performance. Back-stabilizing muscles can be activated more effectively with running than with a prolonged back extension activity. Running can be considered as an efficient, multifunctional exercise combining cardiovascular and trunk endurance benefits.
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Ko, Young-woo, Sun Mi Kim, Kyoung Doo Kang, and Doug Hyun Han. "Changes in Functional Connectivity Between Default Mode Network and Attention Network in Response to Changes in Aerobic Exercise Intensity." Psychiatry Investigation 20, no. 1 (January 25, 2023): 27–34. http://dx.doi.org/10.30773/pi.2022.0245.

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Objective Aerobic exercise may be associated with changes in brain activity within the default mode network (DMN) and dorsal attention network (DAN). We hypothesized that changes in functional connectivity (FC) within the DMN and DAN might be most effectively activated by moderate-intensity exercise.Methods Resting-state functional magnetic resonance imaging scans and visuospatial attention tests after resting were performed before and after each of moderate- and high-intensity aerobic exercises (10 min each) in 15 healthy male volunteers.Results The reaction time during the attention test increased significantly, and the rate of correct responses decreased from moderate-intensity exercise condition to high-intensity exercise condition. FC within the DMN under high-intensity exercise condition was higher than that under pre-exercise and moderate-intensity exercise conditions. FC within the DAN under moderate-intensity exercise condition was the highest, whereas FC between the DMN and DAN under moderate-intensity exercise condition was the lowest. Changes in cognitive domain functions were associated with changes in FC between the DMN and DAN.Conclusion Our results support the inverted-U hypothesis of maximum arousal efficacy during moderate exercise. Both cognitive domains, namely, the attention system and brain activity domains, may be better under moderate-intensity exercise than under high-intensity exercise.
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Moriarty, Terence, Kelsey Bourbeau, Bryanne Bellovary, and Micah N. Zuhl. "Exercise Intensity Influences Prefrontal Cortex Oxygenation during Cognitive Testing." Behavioral Sciences 9, no. 8 (July 26, 2019): 83. http://dx.doi.org/10.3390/bs9080083.

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Activation changes in the prefrontal cortex (PFC) regions have been linked to acute exercise-induced improvements in cognitive performance. The type of exercise performed may influence PFC activation, and further impact cognitive function. The present study aimed to compare PFC activation during cognitive testing after moderate-intensity, high intensity, and yoga exercises, and to determine if PFC activation is linked to cognitive performance. Eight subjects (four male and four female), aged 35 ± 5 completed a control, high intensity, moderate intensity, and yoga exercises followed by administration of a cognitive task (NIH Toolbox Fluid Cognition). Left and right PFC activation (LPFC and RPFC, respectively) were evaluated by measuring hemoglobin difference (Hbdiff) changes during post-exercise cognitive assessment using functional near infrared spectroscopy (fNIRS). Activation during the cognitive test was higher in the LPFC after moderate intensity exercise compared to control, high intensity, and yoga (5.30 ± 6.65 vs. 2.26 ± 2.40, 2.50 ± 1.48, 2.41 ± 2.36 μM, p < 0.05, respectively). A negative relationship was detected between LPFC and processing speed after exercise. PFC activation did not align with cognitive performance. However, acute exercise, regardless of type, appeared to alter neural processing. Specifically, less PFC activation was required for a given neural output after exercise.
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Mahmoud, Tarek H., Mona Sayed Ahmed, Haitham M. Saleh, Nadia Mohamed Abdelhakiem, Raafat Ezzeldeen Abd Elhameed, and Mohamed Ahmed Gad Allah. "Effect of High-intensity Aerobic Exercise Versus Moderate-intensity Aerobic Exercise on Serum Uric Acid in Hypertension." NeuroQuantology 20, no. 4 (April 30, 2022): 552–63. http://dx.doi.org/10.14704/nq.2022.20.4.nq22336.

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Background & purpose: Methods: Thirty hypertensive men (Mild Essential Hypertension) with ages ranging from 45 to 55 years old and BMIs ranging from 25 to 35 kg/m2 took part in the study (overweight and class1 obesity). The participants were classified randomly into two main domains; A and B. As for the first Group, (A) did high-intensity (interval) aerobic activity, while group (B) did moderate-intensity (continuous) aerobic exercise. Both categories exercised for 30-40 minutes on an electrical treadmill three times a week for eight weeks. Blood uric acid, serum creatinine, and serum urea were tested for each patient before and after the trial. The arterial blood pressure measurements were also taken before and after the study to draw comparisons and to set evaluations. Results: Both high-intensity interval and continuous moderate exercise had a significant lowering effect on serum uric acid and creatinine (p.05), with continuous moderate exercise having a better effect with a 16 percent improvement in serum uric acid and a 27.5 percent improvement in creatinine, while high-intensity interval exercise had an 8 percent improvement in serum uric acid and a 17 percent improvement in creatinine. On the other hand, arterial blood pressure and blood urea levels improved at the same rate. Conclusion: Moderate continuous exercise reduces serum uric acid and creatinine better than high-intensity interval exercise. Both have the same effect on blood pressure and urea, but moderate continuous exercise has a crystal-clear effect that cannot be denied.
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Kasahara, Kazuki, Keita Oneyama, Takeru Ito, Masatoshi Nakamura, and Genta Ochi. "Foam Rolling Intervention Improves Lactate Clearance After High-Intensity Exercise." Sports 12, no. 11 (November 8, 2024): 303. http://dx.doi.org/10.3390/sports12110303.

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The acute effects of a foam rolling intervention on lactate clearance and the impaired executive function associated with fatigue after high-intensity exercise remain unclear. This study examined whether foam rolling is an effective tool for fatigue recovery. Eighteen healthy adults without consistent exercise habits participated in this study. Participants performed high-intensity exercises, and the post-exercise foam rolling intervention was compared to the control condition. Measurements included lactate, vigor/fatigue by the Profile of Mood States 2nd Edition, cognitive function (cognitive task performance), leg and body rating of perceived exertion pre- and post-exercise, and post-intervention. Blood lactate concentrations post-foam rolling intervention (−7.3 ± 3.0 mmol/L) were significantly reduced among all participants. Increased lactate clearance by foam rolling correlated with a faster recovery of executive function for those with greater lactate clearance. However, cognitive fatigue was not observed after high-intensity exercise (p = 0.086, r = 0.41). Lactate clearance was not significantly correlated with the rating of perceived exertion in the foam rolling condition. The rating of the perceived exertion decreased with increased lactate clearance for those with greater lactate clearance in the control condition (leg: r = 0.778; body: r = 0.669). In conclusion, foam rolling intervention may be effective for exhausting exercise recovery.
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Lambert, Charles P., and Michael G. Flynn. "Fatigue during High-Intensity Intermittent Exercise." Sports Medicine 32, no. 8 (2002): 511–22. http://dx.doi.org/10.2165/00007256-200232080-00003.

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Kastner, S., C. Becker, and U. Lindemann. "High Intensity Functional Exercise (HIFE) Training." physioscience 13, no. 03 (September 2017): 109–16. http://dx.doi.org/10.1055/s-0035-1567214.

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Zusammenfassung Hintergrund: Das in Schweden entwickelte und evaluierte Trainingsprogramm „High Intensity Functional Exercise“ (HIFE) wird dort zur Sturzprävention im stationären Seniorenpflegebereich eingesetzt. Das Programm besteht aus funktionellen, hochintensiven Kraft- und Balanceübungen und könnte eine wertvolle Ergänzung zu bereits bestehenden Sturzpräventionsprogrammen in Deutschland darstellen. Ziel: Überprüfung der Anwendbarkeit des HIFE-Programms in 2 deutschen Pflegeheimen. Methode: Machbarkeitsstudie einer 10-wöchigen HIFE-Intervention mit 16 Teilnehmern*. Primäre Zielparameter waren Teilnahme- und Drop-out-Raten, Beschwerden und Nebenwirkungen, Akzeptanz bei Heimleitung und Pflegepersonal. Sekundäre Zielparameter umfassten 30-Seconds Chair Rising Test (30 CR), 5-Seconds Chair Rising Test (5 CR), habituelle und maximale Gehgeschwindigkeit, Timed Up and Go Test (TUG), Sit and Reach Test (SR) und Standbalance zur Beschreibung funktioneller Veränderungen im Prä-Post-Vergleich. Ergebnisse: Während der Intervention traten keine schwerwiegenden Nebenwirkungen auf. Teilnahmeraten und Akzeptanz des HIFE-Programms waren bei Heimleitung und Pflegepersonal sehr gut und die Drop-out-Rate gering. Die Standbalance (p < 0,05), funktionelle Beinkraft (30 CR: p < 0,005, 5 CR: p < 0,005) und habituelle Gehgeschwindigkeit (p < 0,05) verbesserten sich signifikant. Die Verbesserungen der maximalen Gehgeschwindigkeit (p = 0,075) und im TUG (p = 0,05) erreichten kein signifikantes Niveau. Die Beweglichkeit beim SR veränderte sich nicht (p = 0,608). Schlussfolgerungen: Das HIFE-Trainingsprogramm lässt sich ist in Deutschland sicher und praktikabel anwenden. Verbesserungen funktioneller Parameter sind zu erwarten, was insgesamt einen wertvollen Beitrag zur Sturzprävention in Seniorenheimen leisten kann.
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Mitchell, Joel B., Melissa M. Rogers, John T. Basset, and Kimberly A. Hubing. "Fatigue During High-Intensity Endurance Exercise." Journal of Strength and Conditioning Research 28, no. 7 (July 2014): 1906–14. http://dx.doi.org/10.1519/jsc.0000000000000319.

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Coyle, Edward F., Joel D. Trinity, Matthew D. Pahnke, Joshua F. Lee, and Kenneth C. Beck. "Cardiac Output During High Intensity Exercise." Medicine & Science in Sports & Exercise 42 (May 2010): 4. http://dx.doi.org/10.1249/01.mss.0000384238.27287.b8.

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KOMIYAMA, TAKAAKI, YUKIYA TANOUE, MIZUKI SUDO, JOSEPH T. COSTELLO, YOSHINARI UEHARA, YASUKI HIGAKI, and SOICHI ANDO. "Cognitive Impairment during High-Intensity Exercise." Medicine & Science in Sports & Exercise 52, no. 3 (March 2020): 561–68. http://dx.doi.org/10.1249/mss.0000000000002183.

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Hwang, Ji Sun, Tae Young Kim, Moon-Hyon Hwang, and Won Jun Lee. "Exercise and Neuroplasticity: Benefits of High Intensity Interval Exercise." Journal of Life Science 26, no. 1 (January 30, 2016): 129–39. http://dx.doi.org/10.5352/jls.2016.26.1.129.

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Salim, Filiani Natalia, Hanna Goenawan, Faysal Kastella, Ronny Lesmana, and Leonardo Lubis. "Effects of Different Intensity Exercises On Bone Structure of Young Male Wistar Rats." Jurnal Pendidikan Jasmani dan Olahraga 8, no. 2 (September 1, 2023): 270–76. http://dx.doi.org/10.17509/jpjo.v8i2.59086.

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Many adolescents have insufficient physical activity. Regular physical activity from young age can improve health and fitness. Getting regular exercise and eating healthy diet should be encouraged among kids and teenagers to prevent various diseases in adulthood and old age, such as osteoporosis and fractures. When exercising, a prescription is needed that is tailored to each individual abilities. The intensity of exercise will be different for each individual in accordance with their age, physiological function, genetics, economic status, and previous comorbid diseases. There is no standardised exercise prescription proven to increase bone mineral density in adolescents. Based on the above description, a study was conducted on the provision of different intensity exercise and its effect on bone morphology and density. In this study, male Wistar rats, aged 15–16 weeks (body weight ± 250-350 grams; n = 20), were split into 4 groups, namely control group, low intensity exercise group, moderate intensity exercise group, and high intensity exercise group. All groups were receiving intervention for 8 weeks. Then, the rats were sacrificed and the femoral bones were isolated. Femur weight and femur length was checked. Bone density was examined using X-Ray and calculated by statistical tests. Research was conducted in the Central Laboratory, Universitas Padjadjaran. There were significant differences of femur weight between high intensity exercise group and control and low intensity exercise groups (p 0.05). Moderate and high intensity exercises significantly increased femur length as opposed to control and low intensity exercise groups (p 0.05). Bone density was higher in moderate and high intensity exercise groups (p 0.05). Moderate to high intensity exercise can increase bone health, seen from significances of bone morphology analysis and a higher density compared to low intensity exercise.
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Navalta, James W., and Stephen P. Hrncir. "Core Stabilization Exercises Enhance Lactate Clearance Following High-Intensity Exercise." Journal of Strength and Conditioning Research 21, no. 4 (2007): 1305. http://dx.doi.org/10.1519/r-21546.1.

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NAVALTA, JAMES W., and STEPHEN P. HRNCIR. "CORE STABILIZATION EXERCISES ENHANCE LACTATE CLEARANCE FOLLOWING HIGH-INTENSITY EXERCISE." Journal of Strength and Conditioning Research 21, no. 4 (November 2007): 1305–9. http://dx.doi.org/10.1519/00124278-200711000-00057.

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30

Wang, Chun-Chih, Chien-Heng Chu, I.-Hua Chu, Kuei-Hui Chan, and Yu-Kai Chang. "Executive Function During Acute Exercise: The Role of Exercise Intensity." Journal of Sport and Exercise Psychology 35, no. 4 (August 2013): 358–67. http://dx.doi.org/10.1123/jsep.35.4.358.

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This study was designed to examine the modulation of executive functions during acute exercise and to determine whether exercise intensity moderates this relationship. Eighty college-aged adults were recruited and randomly assigned into one of the four following groups: control, 30%, 50%, and 80% heart rate reserve. The Wisconsin Card Sorting Test (WCST) was administered during each intervention. The results indicated that the majority of the WCST performances were impaired in the high exercise intensity group relative to those of the other three groups, whereas similar performance rates were maintained in the low- and moderate-intensity groups. These findings suggest that transient hypofrontality occurs during high-intensity exercise, but not during low- and moderate-intensity exercises. Future research aimed at employing the dual-mode theory, and applying the reticular-activating hypofrontality model is recommended to further the current knowledge.
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31

Andrews, Sophie C., Dylan Curtin, Ziarih Hawi, Jaeger Wongtrakun, Julie C. Stout, and James P. Coxon. "Intensity Matters: High-intensity Interval Exercise Enhances Motor Cortex Plasticity More Than Moderate Exercise." Cerebral Cortex 30, no. 1 (May 1, 2019): 101–12. http://dx.doi.org/10.1093/cercor/bhz075.

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Abstract A single bout of cardiovascular exercise can enhance plasticity in human cortex; however, the intensity required for optimal enhancement is debated. We investigated the effect of exercise intensity on motor cortex synaptic plasticity, using transcranial magnetic stimulation. Twenty healthy adults (Mage = 35.10 ± 13.25 years) completed three sessions. Measures of cortico-motor excitability (CME) and inhibition were obtained before and after a 20-min bout of either high-intensity interval exercise, moderate-intensity continuous exercise, or rest, and again after intermittent theta burst stimulation (iTBS). Results showed that high-intensity interval exercise enhanced iTBS plasticity more than rest, evidenced by increased CME and intracortical facilitation, and reduced intracortical inhibition. In comparison, the effect of moderate-intensity exercise was intermediate between high-intensity exercise and rest. Importantly, analysis of each participant’s plasticity response profile indicated that high-intensity exercise increased the likelihood of a facilitatory response to iTBS. We also established that the brain-derived neurotrophic factor Val66Met polymorphism attenuated plasticity responses following high-intensity exercise. These findings suggest that high-intensity interval exercise should be considered not only when planning exercise interventions designed to enhance neuroplasticity, but also to maximize the therapeutic potential of non-invasive brain stimulation. Additionally, genetic profiling may enhance efficacy of exercise interventions for brain health.
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32

Hargreaves, Mark, Michael J. McKenna, David G. Jenkins, Stuart A. Warmington, Jia L. Li, Rodney J. Snow, and Mark A. Febbraio. "Muscle metabolites and performance during high-intensity, intermittent exercise." Journal of Applied Physiology 84, no. 5 (May 1, 1998): 1687–91. http://dx.doi.org/10.1152/jappl.1998.84.5.1687.

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Six men were studied during four 30-s “all-out” exercise bouts on an air-braked cycle ergometer. The first three exercise bouts were separated by 4 min of passive recovery; after the third bout, subjects rested for 4 min, exercised for 30 min at 30–35% peak O2 consumption, and rested for a further 60 min before completing the fourth exercise bout. Peak power and total work were reduced ( P < 0.05) during bout 3 [765 ± 60 (SE) W; 15.8 ± 1.0 kJ] compared with bout 1 (1,168 ± 55 W, 23.8 ± 1.2 kJ), but no difference in exercise performance was observed between bouts 1 and 4 (1,094 ± 64 W, 23.2 ± 1.4 kJ). Before bout 3, muscle ATP, creatine phosphate (CP), glycogen, pH, and sarcoplasmic reticulum (SR) Ca2+ uptake were reduced, while muscle lactate and inosine 5′-monophosphate were increased. Muscle ATP and glycogen before bout 4 remained lower than values before bout 1( P < 0.05), but there were no differences in muscle inosine 5′-monophosphate, lactate, pH, and SR Ca2+ uptake. Muscle CP levels before bout 4 had increased above resting levels. Consistent with the decline in muscle ATP were increases in hypoxanthine and inosine before bouts 3 and 4. The decline in exercise performance does not appear to be related to a reduction in muscle glycogen. Instead, it may be caused by reduced CP availability, increased H+ concentration, impairment in SR function, or some other fatigue-inducing agent.
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Badenhop, Dalynn T., Meghan M. Long, C. Matt Laurent, and K. Todd Keylock. "High-Intensity Interval Versus Moderate-Intensity Continuous Training in Cardiac Rehabilitation." Journal of Clinical Exercise Physiology 9, no. 1 (March 1, 2020): 10–16. http://dx.doi.org/10.31189/2165-6193-9.1.10.

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ABSTRACT Background: Past research has compared the effects of moderate-intensity continuous training (MCT) versus high-intensity interval training (HIIT) in phase 2 cardiac rehabilitation patients, but with conflicting results. Therefore, the purpose of this study was to evaluate if HIIT leads to greater improvements in functional capacity when compared with MCT in a group of phase 2 cardiac rehabilitation patients. Methods: Eighteen patients in a phase 2 cardiac rehabilitation program completed precardiopulmonary and postcardiopulmonary exercise tests, a 12-min walk test (12MWT), and resting blood pressure (BP). After 2 weeks of run-in, patients were randomly assigned to 10 weeks of HIIT (alternating periods of 80%–90% heart rate [HR] reserve and 60%–70% HR reserve) or MCT (60%–80% HR reserve) exercise group. Changes in VO2 peak, 12MWT distance, and BP (mm Hg) were analyzed by independent t test. Results: The average patient was 65 years old, 1.75 m tall, and overweight. VO2 peak values improved for individuals in both exercise modalities. There was no significant difference between the exercise groups (P = 0.174). In addition, both groups improved their 12MWT distance, resting systolic, and diastolic BP (DBP), with no significant difference in improvements between the 2 exercise groups. Conclusion: In this study, HIIT was not more effective than MCT for improving functional capacity in a group of phase 2 cardiac rehabilitation patients. However, since HIIT was equally effective compared with MCT in several measures, it provides another option for exercise prescription to the traditional prescription for this population.
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Qin, Xin-Min, Ji-Young Park, Bo-Ram Kim, and Chang-Hwa Joo. "The Effects of Exercise on Acute Immune Responses in Relative Leisure-Deprived People Living with HIV/AIDS: A Pilot Study." International Journal of Environmental Research and Public Health 19, no. 13 (July 2, 2022): 8155. http://dx.doi.org/10.3390/ijerph19138155.

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Exercise training involving exercises of optimal intensity and duration improves psychological and medical variables in relative leisure-deprived people living with HIV/AIDS. This study aimed to analyze associated psychological variables and the effect of exercise intensity and duration on immune responses in relative leisure-deprived people infected with HIV. The participants completed different moderate-intensity exercises (30 min (60–80% HRmax) and 45 min (60–80% HRmax)) and high-intensity exercise for 10 min (>80% HRmax). Levels higher than “normal” were rated for relative leisure deprivation, indicating relative deprivation of leisure among participants. The overall level of quality of life was “normal”, indicating that quality of life was not considered high. The stress level was psychologically considered low. Time had a significant effect on cortisol levels (p < 0.05). Compared to pre-exercise, cortisol level was significantly decreased immediately after moderate exercise for 45 min and 3 h post-exercise after high-intensity exercise for 10 min (p < 0.05). However, time and the interaction of condition and time had no significant effect on IL-6 and sIgA levels (p > 0.05). Despite the small sample size of this pilot study, the results demonstrate that moderate-intensity exercise can be recommended to improve the health and quality of life of people infected with HIV.
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Gearhart, Randall F., M. Daniel Becque, Chad M. Palm, and Matthew D. Hutchins. "Rating Perceived Exertion during Short Duration, Very High Intensity Cycle Exercise." Perceptual and Motor Skills 100, no. 3 (June 2005): 767–73. http://dx.doi.org/10.2466/pms.100.3.767-773.

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This study compared undifferentiated ratings of perceived exertion (RPE) during short duration, very high intensity cycle exercise using high and low resistance. 30 recreationally trained males (24.2 ± 2.4 yr.) were memory-anchored to the Borg 15-category scale. The high and low resistance exercises were defined by 30-sec. maximum tests assigned in counterbalanced order, with resistances set before testing during an orientation session. High resistance was 10% of body mass. Low resistance resulted in the same total work as the high resistance over the 30-sec. sessions (± 5%) but increased pedal rate. RPE was taken at 8, 13, 18, 23, and 28 sec. during the high and the low resistance exercises. Measurements were compared using a 2-way repeated-measures analysis of variance. RPE was significantly greater ( p = .005) for the high than the low resistance exercise at each interval. RPE increased when the subjects were required to pedal against a greater resistance and produce the highest forces. These RPE data are consistent with data from both aerobic cycle and resistance exercise. The data suggest that instantaneous force production, not summed work, is a primary determinant of RPE. All of these observations support Cafarelli's theoretical model of effort sense. In conclusion, as an individual generates more force during high resistance exercise than in light resistance exercise, a potential explanation of our results is that the increased motor outflow and corollary sensory signal lead to a greater sense of effort.
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Suga, Tadashi, Koichi Okita, Noriteru Morita, Takashi Yokota, Kagami Hirabayashi, Masahiro Horiuchi, Shingo Takada, Masashi Omokawa, Shintaro Kinugawa, and Hiroyuki Tsutsui. "Dose effect on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction." Journal of Applied Physiology 108, no. 6 (June 2010): 1563–67. http://dx.doi.org/10.1152/japplphysiol.00504.2009.

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Our previous study reported that metabolic stress in skeletal muscle achieved by combining moderate blood flow restriction (BFR) with low-intensity resistance exercise at 20% of one repetition maximum (1 RM) could not reach the level achieved by high-intensity resistance exercise. Since the previous protocol is typical of current regimens of this type, we sought in this study to optimize the exercise protocol for low-intensity resistance exercise with BFR by examining the dose effects of exercise intensity and pressure. Twelve healthy subjects participated in this study. They were asked to perform unilateral plantar flexion for 2 min (30 repetitions/min) under six different conditions: two resistance exercises (20% 1 RM and 65% 1 RM) without BFR, and four BFR protocols. The four BFR protocols included three different exercise intensities (20, 30, and 40% 1 RM) with moderate pressure (MP) using 130% of systolic blood pressure (147 ± 17 mmHg, mean ± SD) and 20% 1 RM with high pressure at 200 mmHg. Intramuscular metabolites and pH were obtained by 31P-magnetic resonance spectroscopy. Significant dose effects on intramuscular metabolites and pH were observed for exercise intensity ( P < 0.001) but not for BFR pressure. The BFR protocol combining 30% 1 RM with MP had similar results as the high-intensity load at 65% 1 RM. Intramuscular metabolic stress during BFR exercise might be susceptible to increasing exercise intensity. To replace high-intensity resistance exercise, the BFR protocol might require an intensity of ≥30% 1 RM.
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Vargas, Nicole T., Christopher L. Chapman, Blair D. Johnson, Rob Gathercole, and Zachary J. Schlader. "Exercise intensity independently modulates thermal behavior during exercise recovery but not during exercise." Journal of Applied Physiology 126, no. 4 (April 1, 2019): 1150–59. http://dx.doi.org/10.1152/japplphysiol.00992.2018.

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We tested the hypothesis that thermal behavior is greater during and after high- compared with moderate-intensity exercise. In a 27°C, 20% relative humidity environment, 20 participants (10 women, 10 men) cycled for 30 min at moderate [53% (SD 6) peak oxygen uptake (V̇o2peak) or high [78% (SD 6) V̇o2peak] intensity, followed by 120 min of recovery. Mean skin and core temperatures and mean skin wettedness were recorded continuously. Participants maintained thermally comfortable neck temperatures with a custom-made neck device. Neck device temperature provided an index of thermal behavior. The weighted average of mean skin and core temperatures and mean skin wettedness provided an indication of the afferent stimulus to thermally behave. Mean skin and core temperatures were greater at end-exercise in high intensity ( P < 0.01). Core temperature remained elevated in high intensity until 70 min of recovery ( P = 0.03). Mean skin wettedness and the afferent stimulus were greater at 10–20 min of exercise in high intensity ( P ≤ 0.03) and remained elevated until 60 min of recovery ( P < 0.01). Neck device temperature was lower during exercise in high versus moderate intensity ( P ≤ 0.02). There was a strong relation between the afferent stimulus and neck device temperature during exercise (high: R2 = 0.82, P < 0.01; moderate: R2 = 0.95, P < 0.01) and recovery (high: R2 = 0.97, P < 0.01; moderate: R2 = 0.93, P < 0.01). During exercise, slope ( P = 0.49) and y-intercept ( P = 0.91) did not differ between intensities. In contrast, slope was steeper ( P < 0.01) and y-intercept was higher ( P < 0.01) during recovery from high-intensity exercise. Thermal behavior is greater during high-intensity exercise because of the greater stimulus to behave. The withdrawal of thermal behavior is augmented after high-intensity exercise. NEW & NOTEWORTHY This is the first study to determine the effects of exercise intensity on thermal behavior. We show that exercise intensity does not independently modulate thermal behavior during exercise but is dependent on the magnitude of afferent stimuli. In contrast, the withdrawal of thermal behavior after high-intensity exercise is augmented. This may be a consequence of an attenuated perceptual response to afferent stimuli, which may be due to processes underlying postexercise hypoalgesia.
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Järvinen, Laura, Sofi Lundin Petersdotter, and Thomas Chaillou. "High-intensity resistance exercise is not as effective as traditional high-intensity interval exercise for increasing the cardiorespiratory response and energy expenditure in recreationally active subjects." European Journal of Applied Physiology 122, no. 2 (November 19, 2021): 459–74. http://dx.doi.org/10.1007/s00421-021-04849-4.

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Abstract Purpose Traditional high-intensity interval exercise (HIIE) highly stimulates the cardiorespiratory system and increases energy expenditure (EE) during exercise. High-intensity resistance exercise (HIRE) has become more popular in recreationally active subjects. The physiological responses to HIRE performed with light or moderate load is currently largely unknown. Here, we examined the effect of the type of interval exercise [HIRE at 40% (HIRE40) and 60% (HIRE60) 1-RM vs. traditional HIIE] on the cardiorespiratory response and EE during and after exercise. Methods Fifteen recreationally active adults randomly completed traditional HIIE on an ergocyle, HIRE40 and HIRE60. The sessions consisted of two sets of ten 30-s intervals (power at 100% VO2max during HIIE; maximal number of repetitions for 10 different free-weight exercises during HIRE40 and HIRE60) separated by 30-s active recovery periods. Gas exchange, heart rate (HR) and EE were assessed during and after exercise. Results VO2mean, VO2peak, HRmean, the time spent above 90% VO2max and HRmax, and aerobic EE were lower in both HIRE sessions compared with HIIE (P < 0.05). Anaerobic glycolytic contribution to total exercise EE was higher in HIRE40 and HIRE60 compared with HIIE (P < 0.001). EE from excess post-exercise oxygen consumption (EPOC) was similar after the three sessions. Overall, similar cardiorespiratory responses and EE were found in HIRE40 and HIRE60. Conclusions HIRE is not as effective as HIIE for increasing the cardiorespiratory response and EE during exercise, while EPOC remains similar in HIRE and HIIE. These parameters are not substantially different between HIRE40 and HIRE60.
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Rodrigues, Alesson, and Leonardo De Lucca. "Acute leptin response after high intensity interval and moderate intensity continuous runs." European Journal of Human Movement 45 (2020): 26–35. http://dx.doi.org/10.21134/eurjhm.2020.45.3.

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The possible direct role of exercise intensity and duration on leptin concentrations is conflicting. The aim of this study was to evaluate the acute effects of high intensity interval (HIIE) and moderate intensity continuous (MICE) exercise on plasma leptin response. Seven young volunteers underwent three tests: 1) a treadmill graded exercise test to identify running peak velocity (PV); 2) HIIE: 5 × 2 min work bouts at 90% of PV, interspersed by 2 min of passive recovery and; 3) MICE: 30 min at 70 % of PV. Blood samples were drawn for the assays of leptin before and 30 minutes after HIIE and MICE. A 2-way repeated measures ANOVA showed a significant main effect of time [F(1,6) =17,52; p=0,006], no significant effect of condition (type of exercise) (F(1,6) = 0,16; p = 0,68) and no significant interaction (condition × time) (F(1,6)= 0,48, p=0,51). Leptin decreased 30 min after HIIE (t= 2,95, p=0,025) and MICE (t=4,18; p=0,005). There was no difference between the HIIE and MICE conditions immediately after exercise (t=0,90; p=0,40). After HIIE and MICE, leptin decreased in the same magnitude. It appears that both exercise modalities result in physical stress which is sufficient to improve short-term leptin sensibility.
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40

Shin, Min-Ja, Jaeuk U. Kim, Jin-Hee You, and Won-Sop Shin. "Effects of Exercise Intensity Differences in Forest Therapy Programs on Immunoglobulin A and Dehydroepiandrosterone Levels in Older Adults." Forests 15, no. 4 (March 22, 2024): 577. http://dx.doi.org/10.3390/f15040577.

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The purpose of this study was to examine the effects of exercise intensity and the duration of an exercise-based forest therapy program on physiological changes in older adults. The forest therapy program consisted of 20 sessions over 10 weeks. Forty-one older adults aged 65 years and older were divided into no treatment (daily activity group) and experimental (forest therapy) groups. The experimental group was further divided into the medium-intensity forest exercise group and the high-intensity forest exercise group to analyze physiological changes according to exercise intensity and duration. The physiological changes were analyzed by collecting saliva and measuring changes in the levels of immunoglobulin A and dehydroepiandrosterone, a hormone used to predict aging. Changes within the daily activity group and the forest therapy group after their respective exercises were analyzed using paired t-tests. Saliva testing was performed before and in weeks 5 and 10 of the program and analyzed using a repeated measures analysis of variance to assess the effects of the forest therapy on the medium-intensity forest exercise group and the high-intensity forest exercise group based on the duration of exercise. As a result of the study, a significant increase in immunoglobulin A was observed in the medium-intensity forest exercise group. The daily activity group and the high-intensity forest exercise group showed an increase, but there was very little change and no significance. Changes in dehydroepiandrosterone decreased in the daily activity group and significantly increased in the moderate-intensity forest exercise group at 5 and 10 weeks, showing that regular moderate-intensity forest exercise has an effect on dehydroepiandrosterone. The high-intensity forest exercise group improved over time, but no significant level of change was observed. This study shows that forest exercise has a beneficial effect on immunoglobulin A and dehydroepiandrosterone levels in older adults.
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Suzuki, Katsuhiko, and Harumi Hayashida. "Effect of Exercise Intensity on Cell-Mediated Immunity." Sports 9, no. 1 (January 11, 2021): 8. http://dx.doi.org/10.3390/sports9010008.

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Moderate-intensity exercise is considered to enhance immune function and to be useful for preventing acute upper respiratory infections and similar conditions. Many people practice low-intensity short-duration exercise with the expectation of a beneficial effect on immunocompetency. However, it is difficult to affirm the existence of definite evidence of such a benefit. In this article, we discuss the effects of low-intensity short-duration exercise on cell-mediated immunity, and contrast them to the effects of high-intensity and long-duration exercise. Whereas high-intensity exercise induces inflammation and reduces cell-mediated immune system function, low-intensity exercise does not appear to have a large effect on either inflammation or cell-mediated immune function. Low-intensity exercises such as walking and yoga, which are helpful to relieve stress, cannot be considered as harmful to the immune system. Although yoga was shown to impose fewer restrictions on breathing and physical strain, the evidence that yoga enhances cell-mediated immunity remains insufficient. Therefore, further studies are needed to examine the exercise mode that may be most effective for improvement of immune functions.
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Suzuki, Katsuhiko, and Harumi Hayashida. "Effect of Exercise Intensity on Cell-Mediated Immunity." Sports 9, no. 1 (January 11, 2021): 8. http://dx.doi.org/10.3390/sports9010008.

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Moderate-intensity exercise is considered to enhance immune function and to be useful for preventing acute upper respiratory infections and similar conditions. Many people practice low-intensity short-duration exercise with the expectation of a beneficial effect on immunocompetency. However, it is difficult to affirm the existence of definite evidence of such a benefit. In this article, we discuss the effects of low-intensity short-duration exercise on cell-mediated immunity, and contrast them to the effects of high-intensity and long-duration exercise. Whereas high-intensity exercise induces inflammation and reduces cell-mediated immune system function, low-intensity exercise does not appear to have a large effect on either inflammation or cell-mediated immune function. Low-intensity exercises such as walking and yoga, which are helpful to relieve stress, cannot be considered as harmful to the immune system. Although yoga was shown to impose fewer restrictions on breathing and physical strain, the evidence that yoga enhances cell-mediated immunity remains insufficient. Therefore, further studies are needed to examine the exercise mode that may be most effective for improvement of immune functions.
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Kim, Tae-Hwan, Ji Hui Shin, and Bon San Koo. "Exercise in Korean Patients with Axial Spondyloarthritis: A Questionnaire-Based Study." Korean Journal of Medicine 100, no. 1 (February 1, 2025): 31–39. https://doi.org/10.3904/kjm.2025.100.1.31.

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Background/Aims: Exercise is a key component of the management of axial spondyloarthritis (axSpA), providing symptomatic relief and helping prevent ankylosis. However, there is a lack of quantitative studies evaluating daily exercise patterns in patients with axSpA. This study assessed the types, frequency, and duration of exercises performed by these patients through a structured questionnaire.Methods: This cross-sectional study included radiographic axSpA patients who visited a rheumatology clinic between September 2014 and March 2016 and provided informed consent to participate. The survey captured information on four types of exercise: high-intensity exercise, moderate-intensity exercise, strength training, and walking. Disease activity and functional status were evaluated using the Bath ankylosing spondylitis disease activity index (BASDAI) and the Bath ankylosing spondylitis functional index (BASFI), respectively.Results: A total of 645 patients participated in the study. Among them, 25.1% engaged in high-intensity exercise, 36.0% in moderate-intensity exercise, 81.2% in walking, and 32.8% in strength training. The median weekly exercise frequency was 3.0 days (interquartile range [IQR], 2.0-4.0) for high-intensity exercise, 3.0 days (IQR, 2.0-5.0) for moderate-intensity exercise, 5.5 days (IQR, 4.0-7.0) for walking, and 3.0 days (IQR, 2.0-5.0) for strength training. The median daily exercise duration was 60 minutes (IQR, 60-120) for high-intensity exercise, 60 minutes (IQR, 30-90) for moderate-intensity exercise, 30 minutes (IQR, 20-60) for walking, and 30 minutes (IQR, 20-60) for strength training. Comparisons by disease activity showed that BASFI scores were more strongly associated with differences in exercise patterns than BASDAI scores.Conclusion: Radiographic axSpA patients predominantly engaged in low-intensity activities, particularly walking, typically for short durations. Given the observed variations in exercise patterns based on disease activity, personalized exercise education and guidance should be prioritized in clinical practice to optimize axSpA management.
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Köhnke, Julija E., Damian L. Mialkowskyj, and Vaiva Hendrixson. "EXPLORING THE LINK BETWEEN MYOKINE CONCENTRATION AND EXERCISE INTENSITY IN YOUNG INDIVIDUALS." Health Sciences 35, no. 1 (January 1, 2025): 56–61. https://doi.org/10.35988/sm-hs.2025.009.

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Physical activity offers numerous health benefits, inclu­ding improved brain function, weight management, dise­ase prevention, and enhanced muscle and bone strength. This study aimed to explore the link between exercise intensity and myokine concentrations, specifically Brain- Derived Neurotrophic Factor (BDNF) and Irisin, in young individuals. Fifteen participants performed both low- and high-intensity exercises, with blood samples taken before and after exercise for analysis using ELISA. While no significant difference in myokine levels or exer­cise intensity was observed, a strong positive correlation between total exercise and BDNF/Irisin concentrations was found, suggesting greater benefits from high-inten­sity exercise. Interestingly, a correlation between BDNF and Irisin themselves was found as well as their corre­lation with fat mass. These findings may have important implications for clinical practices related to metabolic health and cognitive function, though further research with larger sample sizes and varied testing conditions is recommended. Introduction. Engaging in moderate-to-vigorous physi­cal activity provides considerable health benefits. Du­ring exercise small proteins – myokines – are produced and released by striated skeletal muscle cells and have diverse functions, including anti-inflammatory effects, regulation of metabolism, and modulation of muscle growth and repair. The aim of this study is to investigate whether a link can be found between the concentration of myokines and exercise intensity in young individuals. The objectives were to determine if myokine levels increase following low- and high-intensity exercise at two different time points: 1-hour and 24-hours post-exercise; to investigate potential differences in myokine levels between low- and high-intensity exercises, aiming to provide insights into the type of exercise that most significantly raises myokine concentration; and to explore the interrelation (cross-talk) between Brain-Derived Neurotrophic Factor (BDNF) and Irisin levels in response to physical exercise. Material and Methods. Fifteen young adult volunteers were investigated. They were required to engage in exer­cises of both low- and high-intensity levels. Blood sam­ples were taken before and after exercise, then centrifu­ged and subsequently analyzed using ELISA. Efforts to comprehend the link between BDNF, Irisin, and exercise offer potential for devising tailored interventions aimed at enhancing cognitive function and metabolic health through physical activity. The results showed no statistical difference between myo­kine secretion and the intensity of exercises. Also, no increase of myokine levels after exercising was obser­ved. However, a strong positive correlation was obser­ved between the myokine concentration of total exer­cise (low- and high-intensity exercise) for BDNF and Irisin and subjective perception of high-intensity exer­cise showing a possible higher benefit in high-intensity exercise. Interestingly, a correlation between BDNF and Irisin themselves was found as well as their correlation with fat mass. Conclusions. The findings from this research could signi­ficantly influence clinical practice, especially in mana­ging conditions associated with fat mass and metabolism, as well as cognitive functions. Further research involving larger test groups and varied blood sample collection ti­mes would be advantageous.
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45

González-Mohíno, Fernando, Victor Rodrigo-Carranza, Daniel Juárez Santos-García, Anthony P. Turner, and José María González-Ravé. "Acute effects of the sequence of concurrent high-intensity resistance and endurance exercises in recreational athletes." Journal of Human Sport and Exercise 20, no. 1 (October 30, 2024): 228–37. http://dx.doi.org/10.55860/9a326a77.

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This study aimed to assess the acute effects of the sequence of concurrent training (CT) on physiological, neuromuscular, and perceptive parameters in recreational athletes. Eighteen active men (mean ± SD: 22.00 ± 2.00 years; 79.40 ± 9.87 kg and 175.62 ± 6.35 cm) performed two CT sessions consisting of repeated sprint endurance exercise followed by resistance exercise (E-R) or the reverse sequence (R-E) in a randomized order. The E exercise consisted of 6x30s of cycling “all-out” interspersed by 15s of passive recovery, while the R exercise consisted of 3x15 repetitions near failure (1 repetition in reserve) of back squat exercise with rest intervals of 45s. Height in CMJ, heart rate (HR), rating of perceived exertion (RPE) after each exercise, and at the final of the session (sRPE) were recorded. The R-E sequence showed a higher HR at 10s, 1min and 6min (p < .05) post E exercise compared to R exercise. Significant protocol x time interactions were observed for sRPE (p < .001) being higher after the R-E sequence compared to E-R sequence. RPE was significantly higher (p < .01) after E exercise compared to R exercise in both sequences, without differences between the E exercises. However, there were significant differences between the R exercises (p < .01) being higher in the R-E sequence. Our results suggest that the order of exercises during CT affects the second exercise when performed in a R-E sequence, with more cardiovascular stress and higher perceived exertions.
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46

Focht, Brian C., and Heather A. Hausenblas. "State Anxiety Responses to Acute Exercise in Women with High Social Physique Anxiety." Journal of Sport and Exercise Psychology 25, no. 2 (June 2003): 123–44. http://dx.doi.org/10.1123/jsep.25.2.123.

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This study examined the state anxiety (SA) and perceived arousal (AS) responses to self-selected or imposed-intensity bouts of acute exercise performed in different environments by 30 women with high social physique anxiety (SPA). Participants were randomly assigned to a self-selected or imposed-intensity choice group and subsequently (a) exercised in a naturalistic environment, (b) exercised in a laboratory environment, and (c) rested quietly. Assessments of SA and AS were obtained before, during, and following each condition and data were analyzed via separate 2 × 3 × 6 (Intensity Choice × Condition × Time) ANOVAs with repeated measures on the Condition and Time factors. Results revealed that AS increased during both exercise conditions. Conversely, SA was elevated only during the naturalistic exercise condition, and item-level analysis revealed that this increase was composed of both activation and apprehension/worry inventory items. Although SA was reduced 5 min following both exercise conditions, the anxiolytic effect only persisted following the laboratory condition. No significant differences in SA or AS were observed between the two groups. It is concluded that environmentally-induced perceived evaluative threat is associated with an increase in SA during exercise and may attenuate postexercise anxiolysis in women with high SPA.
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47

Hellsten, Y., B. Sjödin, E. A. Richter, and J. Bangsbo. "Urate uptake and lowered ATP levels in human muscle after high-intensity intermittent exercise." American Journal of Physiology-Endocrinology and Metabolism 274, no. 4 (April 1, 1998): E600—E606. http://dx.doi.org/10.1152/ajpendo.1998.274.4.e600.

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The exchange of purines in exercised and rested muscle and their relation to muscle ATP levels after intense intermittent exercise were investigated. Seven subjects performed one-legged knee extensor exercise on the following two occasions: without (control; C) and with (high purines; HP) additional arm exercise. There was a greater net release of hypoxanthine by the exercised muscle during the recovery period in HP compared with C [185 ± 44 vs. 101 ± 30 (SE) μmol/kg muscle; P < 0.05]. During recovery, the arterial urate concentration was higher in HP compared with C (peak: 585 ± 48 vs. 355 ± 20 μmol/l; P < 0.05). The exercised but not the rested muscle extracted a marked amount of urate (330 μmol/kg muscle) from plasma in the HP trial. Muscle ATP levels after 90 min of recovery in HP were lower than at rest (24.3 ± 0.6 vs. 20.1 ± 1.1 mmol/kg dry wt). The present data suggest that a single session of long-term high-intensity intermittent exercise causes a significant release of purines from the muscle into blood, which contributes to a sustained lowered level of the muscle ATP concentration. Furthermore, intensely exercised muscle extracts urate when plasma urate is elevated, an event that may be of importance for the replenishment of oxidized muscle urate stores.
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48

Byrd, S. K., L. J. McCutcheon, D. R. Hodgson, and P. D. Gollnick. "Altered sarcoplasmic reticulum function after high-intensity exercise." Journal of Applied Physiology 67, no. 5 (November 1, 1989): 2072–77. http://dx.doi.org/10.1152/jappl.1989.67.5.2072.

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This study examined the effects of acute high-intensity exercise on the rate and capacity of Ca2+ uptake and Ca2+-stimulated adenosinetriphosphatase (ATPase) activity of the sarcoplasmic reticulum and the reversibility of these effects. Thoroughbred horses were run at maximal O2 uptake on a high-speed treadmill until fatigued. Muscle temperatures and biopsy samples were collected at rest, immediately after exercise, and 30 and 60 min after exercise. Blood samples were collected at rest and 5 min after exercise. Muscle and blood (lactate concentration) were three- and fivefold greater than pre-exercise values. Muscle temperature and pH immediately after post-exercise were 43 degrees C and 6.55, respectively, but approached rest values by 60 min after exercise. The initial rate and maximal capacity of Ca2+ uptake of muscle homogenates and isolated sarcoplasmic reticulum were significantly depressed immediately after exercise. This depression was paralleled by decreased activity of the Ca2+-stimulated ATPase. However, both Ca2+ uptake (rate and capacity) and Ca2+4-ATPase activity had returned to normal by 60 min after exercise. These findings demonstrate that changes in sarcoplasmic reticulum function after high-intensity exercise may be induced but not sustained by local changes in muscle pH and/or temperature.
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49

Leite, Carine D. F. C., Paulo V. C. Zovico, Roberta L. Rica, Bruna M. Barros, Alexandre F. Machado, Alexandre L. Evangelista, Richard D. Leite, Valerio G. Barauna, Adriano F. Maia, and Danilo S. Bocalini. "Exercise-Induced Muscle Damage after a High-Intensity Interval Exercise Session: Systematic Review." International Journal of Environmental Research and Public Health 20, no. 22 (November 20, 2023): 7082. http://dx.doi.org/10.3390/ijerph20227082.

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High-intensity interval training (HIIT) is considered an effective method to improve fitness and health indicators, but its high-intensity exercises and the mechanical and metabolic stress generated during the session can lead to the occurrence of exercise-induced muscle damage. Therefore, this study aimed to describe, by means of a systematic review, the effects of a single HIIT session on exercise-induced muscle damage. A total of 43 studies were found in the Medline/PubMed Science Direct/Embase/Scielo/CINAHL/LILACS databases; however, after applying the exclusion criteria, only 15 articles were considered eligible for this review. The total sample was 315 participants. Among them, 77.2% were men, 13.3% were women and 9.5 uninformed. Their age ranged from 20.1 ± 2 to 47.8 ± 7.5 years. HIIT protocols included running with ergometers (n = 6), CrossFit-specific exercises (n = 2), running without ergometers (n = 3), swimming (n = 1), the Wingate test on stationary bicycles (n = 2), and cycling (n = 1). The most applied intensity controls were %vVO2max, “all out”, MV, MAV, Vmax, and HRreserve%. The most used markers to evaluate muscle damage were creatine kinase, myoglobin, and lactate dehydrogenase. The time for muscle damage assessment ranged from immediately post exercise to seven days. HIIT protocols were able to promote changes in markers of exercise-induced muscle damage, evidenced by increases in CK, Mb, LDH, AST, ALT, pain, and muscle circumference observed mainly immediately and 24 h after the HIIT session.
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50

Padilha, Camila S., Francois Billaut, Caique Figueiredo, Valéria Leme Gonçalves Panissa, Fabrício Eduardo Rossi, and Fabio S. Lira. "Capsaicin Supplementation during High-intensity Continuous Exercise: A Double-blind Study." International Journal of Sports Medicine 41, no. 14 (July 21, 2020): 1061–66. http://dx.doi.org/10.1055/a-1088-5388.

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AbstractTo investigate the effect of acute capsaicin (CAP) supplementation on time to exhaustion, physiological responses and energy systems contribution during continuous high-intensity exercise session in runners. Fifteen recreationally-trained runners completed two randomized, double-blind continuous high-intensity exercises at the speed eliciting 90% V̇O2peak (90% s V̇O2peak), 45 minutes after consuming capsaicin or an isocaloric placebo. Time to exhaustion, blood lactate concentration, oxygen consumption during and 20-min post-exercise, energy systems contribution, time to reach V̇O2peak, heart rate and the rate of perceived exertion (RPE) were evaluated. There was no significant difference between conditions for time to reach V̇O2peak (CAP:391.71±221.8 vs. PLA:298.20±174.5 sec, ES:0.58, p=0.872), peak lactate (CAP:7.98±2.11 vs. PLA:8.58±2.15 µmol, ES:−0.28, p=0.257), time to exhaustion (CAP:654.28±195.44 vs. PLA:709.20±208.44 sec, ES:−0.28, p=0.462, end-of-exercise heart rate (CAP:177.6±14.9 vs. PLA:177.5±17.9 bpm, ES:−0.10, p=0.979) and end-of-exercise RPE (CAP: 19±0.8 vs. PLA: 18±2.4, ES: 0.89, p=0.623). In conclusion, acute CAP supplementation did not increase time to exhaustion during high-intensity continuous exercise nor alter physiological responses in runners.
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